Aliases for ABCG4 Gene
Aliases for ABCG4 Gene
External Ids for ABCG4 Gene
- HGNC: 13884
- Entrez Gene: 64137
- Ensembl: ENSG00000172350
- OMIM: 607784
- UniProtKB: Q9H172
Previous GeneCards Identifiers for ABCG4 Gene
- GC11P135476
- GC11P120533
- GC11P119054
- GC11P118557
- GC11P118558
- GC11P118524
- GC11P119019
- GC11P114959
Summaries for ABCG4 Gene
-
The protein encoded by this gene is a member of the ATP-binding cassette (ABC) transporter superfamily. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). The encoded protein is a member of the White subfamily and plays an important role in cellular cholesterol homeostasis. This protein functions as either a homodimer or as a heterodimer with another ABC subfamily protein such as ABCG1. [provided by RefSeq, Jan 2017]
GeneCards Summary for ABCG4 Gene
ABCG4 (ATP Binding Cassette Subfamily G Member 4) is a Protein Coding gene. Among its related pathways are CDK-mediated phosphorylation and removal of Cdc6 and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and ATPase activity. An important paralog of this gene is ABCG1.
UniProtKB/Swiss-Prot for ABCG4 Gene
-
May be involved in macrophage lipid homeostasis.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ABCG4 Gene
Genomics for ABCG4 Gene
GeneHancer (GH) Regulatory Elements for ABCG4 Gene
Regulatory Element Products
Genomic Locations for ABCG4 Gene
- chr11:119,149,012-119,162,666
- (GRCh38/hg38)
- Size:
- 13,655 bases
- Orientation:
- Plus strand
- chr11:119,019,722-119,033,375
- (GRCh37/hg19)
Genomic View for ABCG4 Gene
- Cytogenetic band:
-
- 11q23.3 by Ensembl
- 11q23.3 by Entrez Gene
- 11q23.3 by HGNC


RefSeq DNA sequence for ABCG4 Gene
Proteins for ABCG4 Gene
-
Protein details for ABCG4 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9H172-ABCG4_HUMAN
- Recommended name:
- ATP-binding cassette sub-family G member 4
- Protein Accession:
- Q9H172
- A8K1B5
- Q8WWH0
- Q8WWH1
- Q8WWH2
Protein attributes for ABCG4 Gene
- Size:
- 646 amino acids
- Molecular mass:
- 71896 Da
- Quaternary structure:
- No Data Available
Protein Expression for ABCG4 Gene
Post-translational modifications for ABCG4 Gene
- Glycosylation at Asn422
Other Protein References for ABCG4 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
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- Novus Biologicals Antibodies for ABCG4
-
Abcam antibodies for ABCG4
-
Cloud-Clone Corp. Antibodies for ABCG4
- Invitrogen Antibodies for ABCG4
- GeneTex ABCG4 antibody for ABCG4
Protein Products
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-
Cloud-Clone Corp. Proteins for ABCG4
- antibodies-online: Search results for 4 available ABCG4 Proteins ranked by validation data
- Compare Top ABCG4 Proteins
-
Quality Products:
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-
Abcam proteins for ABCG4
Assay Products
No data available for DME Specific Peptides for ABCG4 Gene
Domains & Families for ABCG4 Gene
Gene Families for ABCG4 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Predicted membrane proteins
- Transporters
Protein Domains for ABCG4 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for ABCG4 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9H172UniProtKB/Swiss-Prot:
ABCG4_HUMAN :- Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
- Family:
-
- Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
Function for ABCG4 Gene
Molecular function for ABCG4 Gene
- UniProtKB/Swiss-Prot Function:
- May be involved in macrophage lipid homeostasis.
Phenotypes From GWAS Catalog for ABCG4 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | 16870176 |
GO:0005524 | ATP binding | IEA | -- |
GO:0016887 | ATPase activity | IEA | -- |
GO:0017127 | cholesterol transporter activity | TAS | -- |
GO:0034041 | sterol-transporting ATPase activity | IBA | -- |
Phenotypes for ABCG4 Gene
- MGI mutant phenotypes for ABCG4:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for ABCG4:
Animal Models for ABCG4 Gene
- MGI Knock Outs for ABCG4:
-
- Abcg4 tm1Dgen
Animal Model Products
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-
-
ViGene Biosciences lentiviral particle packaged cDNA for ABCG4 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for ABCG4 gene
- Search ViGene Biosciences for ABCG4
CRISPR Products
-
OriGene CRISPR knockouts for ABCG4
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- Overview of 85 available ABCG4 gene related products
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-
Vectors and viruses for KO, Activation, Repression, and more
-
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miRNA for ABCG4 Gene
- miRTarBase miRNAs that target ABCG4
-
- hsa-mir-26b-5p (MIRT030047)
- hsa-mir-185-5p (MIRT733696)
- hsa-mir-1915-3p (MIRT763408)
- hsa-mir-4436b-3p (MIRT769108)
- hsa-mir-4632-5p (MIRT770480)
- hsa-mir-4685-5p (MIRT771048)
- hsa-mir-4687-3p (MIRT771060)
- hsa-mir-548q (MIRT774477)
- hsa-mir-6721-5p (MIRT777820)
- hsa-mir-6735-5p (MIRT778026)
- hsa-mir-6764-5p (MIRT778497)
- hsa-mir-6765-3p (MIRT778526)
- hsa-mir-6837-5p (MIRT780074)
- hsa-mir-6879-5p (MIRT780798)
- hsa-mir-7843-5p (MIRT782102)
miRNA Products
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- Overview of 85 available ABCG4 gene related products
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ViGene Biosciences ready-to-package AAV shRNAs for ABCG4 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for ABCG4
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for ABCG4
-
ViGene Biosciences adenoviral particle packaged cDNA for ABCG4 gene
-
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-
ViGene Biosciences ready-to-package AAV shRNAs for ABCG4 gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ABCG4 Gene
Localization for ABCG4 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ABCG4 Gene
- Membrane; Multi-pass membrane protein.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005886 | plasma membrane | IBA,TAS | -- |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IBA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for ABCG4 Gene
Pathways & Interactions for ABCG4 Gene
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | CDK-mediated phosphorylation and removal of Cdc6 |
.32
|
|
2 | Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds |
Pathways by source for ABCG4 Gene
3 Reactome pathways for ABCG4 Gene
1 KEGG pathway for ABCG4 Gene
Interacting Proteins for ABCG4 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006810 | transport | IEA | -- |
GO:0033344 | cholesterol efflux | TAS | 16682745 |
GO:0055085 | transmembrane transport | TAS | -- |
GO:1990830 | cellular response to leukemia inhibitory factor | IEA | -- |
No data available for SIGNOR curated interactions for ABCG4 Gene
Transcripts for ABCG4 Gene
mRNA/cDNA for ABCG4 Gene
- (6) REFSEQ mRNAs :
- (20) Additional mRNA sequences :
- (23) Selected AceView cDNA sequences:
- (6) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for ABCG4 Gene
CRISPR Products
-
OriGene CRISPR knockouts for ABCG4
- genomics-online: gRNA clones - Search results for 85 available ABCG4 gene related products
- Overview of 85 available ABCG4 gene related products
- Applied Biological Materials CRISPR for ABCG4
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ABCG4
- GenScript: Design CRISPR guide RNA sequences for ABCG4
miRNA Products
- Search ViGene Biosciences for ABCG4
Inhibitory RNA Products
- Origene RNAi and shrna products in human, mouse, rat for ABCG4
- Browse OriGene Inhibitory RNA Products For ABCG4
- genomics-online: shRNA clones - Search results for 85 available ABCG4 gene related products
- Overview of 85 available ABCG4 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for ABCG4 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for ABCG4
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ABCG4
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for ABCG4
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for ABCG4 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
-
Blood (Hematopoietic System)
- Proerythroblasts Hematopoietic Bone Marrow
- Neural Tube (Nervous System)
- Liver (Hepatobiliary System)
mRNA differential expression in normal tissues according to GTEx for ABCG4 Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ABCG4 Gene
NURSA nuclear receptor signaling pathways regulating expression of ABCG4 Gene:
ABCG4SOURCE GeneReport for Unigene cluster for ABCG4 Gene:
Hs.126378mRNA Expression by UniProt/SwissProt for ABCG4 Gene:
Q9H172-ABCG4_HUMANEvidence on tissue expression from TISSUES for ABCG4 Gene
- Nervous system(4.4)
- Lung(4.2)
- Liver(2)
Primer Products
-
OriGene qPCR primer pairs for ABCG4
-
OriGene qPCR primer pairs and template standards for ABCG4
- genomics-online: primer clones - Search results for 85 available ABCG4 gene related products
- Overview of 85 available ABCG4 gene related products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for ABCG4 Gene
Orthologs for ABCG4 Gene
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | ABCG4 34 33 |
|
OneToOne | |
dog (Canis familiaris) |
Mammalia | ABCG4 34 33 |
|
OneToOne | |
oppossum (Monodelphis domestica) |
Mammalia | ABCG4 34 |
|
OneToOne | |
rat (Rattus norvegicus) |
Mammalia | Abcg4 33 |
|
||
mouse (Mus musculus) |
Mammalia | Abcg4 16 34 33 |
|
||
cow (Bos Taurus) |
Mammalia | ABCG4 34 33 |
|
OneToOne | |
platypus (Ornithorhynchus anatinus) |
Mammalia | ABCG4 34 |
|
OneToOne | |
chicken (Gallus gallus) |
Aves | ABCG4 33 34 |
|
||
lizard (Anolis carolinensis) |
Reptilia | ABCG4 34 |
|
OneToOne | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | abcg4 33 |
|
||
zebrafish (Danio rerio) |
Actinopterygii | abcg4a 34 |
|
OneToMany | |
abcg4b 34 |
|
OneToMany | |||
abcg4 33 |
|
||||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP001858 33 |
|
||
fruit fly (Drosophila melanogaster) |
Insecta | Atet 35 33 34 |
|
||
BEST:CK02656 35 |
|
|
|||
CG9663 35 34 |
|
||||
CG5853 35 34 |
|
||||
CG3164 34 |
|
ManyToMany | |||
CG9664 34 |
|
ManyToMany | |||
CG4822 35 34 |
|
||||
CG9892 35 |
|
|
|||
E23 35 34 |
|
||||
CG31689 34 |
|
ManyToMany | |||
w 35 34 |
|
||||
CG32091 34 |
|
ManyToMany | |||
CG17646 34 |
|
ManyToMany | |||
st 35 34 |
|
||||
worm (Caenorhabditis elegans) |
Secernentea | F02E11.1 35 |
|
|
|
C05D10.3 35 |
|
|
|||
C10C6.5 35 |
|
|
|||
C16C10.12 35 |
|
|
|||
F19B6.4 35 |
|
|
|||
wht-4 34 |
|
ManyToMany | |||
Y47D3A.11 35 |
|
|
|||
T26A5.1 35 |
|
|
|||
wht-2 34 |
|
ManyToMany | |||
wht-8 34 |
|
ManyToMany | |||
wht-3 34 |
|
ManyToMany | |||
wht-6 34 |
|
ManyToMany | |||
wht-5 34 |
|
ManyToMany | |||
baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | ADP1 34 |
|
OneToMany | |
thale cress (Arabidopsis thaliana) |
eudicotyledons | AT4G27420 33 |
|
||
rice (Oryza sativa) |
Liliopsida | Os.7232 33 |
|
||
sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany | |
sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.681 33 |
|
- Species where no ortholog for ABCG4 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for ABCG4 Gene
(5) SIMAP similar genes for ABCG4 Gene using alignment to 6 proteins:
Variants for ABCG4 Gene
SNP ID | Clin | Chr 11 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs193920956 | uncertain-significance, Malignant tumor of prostate | 119,150,202(+) | G/C/T | 5_prime_UTR_variant, coding_sequence_variant, genic_upstream_transcript_variant, missense_variant | |
rs1000152386 | -- | 119,152,120(+) | G/A | genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant | |
rs1000326400 | -- | 119,159,100(+) | G/T | intron_variant | |
rs1001093937 | -- | 119,148,942(+) | G/A | upstream_transcript_variant | |
rs1001151479 | -- | 119,163,159(+) | G/T | downstream_transcript_variant |
Additional Variant Information for ABCG4 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- ABCG4
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ABCG4 Gene
Disorders for ABCG4 Gene
Additional Disease Information for ABCG4
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for ABCG4 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ABCG4 Gene
Publications for ABCG4 Gene
- Human and mouse orthologs of a new ATP-binding cassette gene, ABCG4. (PMID: 11856881) Annilo T … Allikmets R (Cytogenetics and cell genetics 2001) 3 4 22 58
- Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
- Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects. (PMID: 19343046) Saito A … Kamatani N (Journal of human genetics 2009) 3 44 58
- Integrative predictive model of coronary artery calcification in atherosclerosis. (PMID: 19948975) McGeachie M … Ramoni MF (Circulation 2009) 3 44 58
- Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations. (PMID: 18660489) Lu Y … Boer JM (Journal of lipid research 2008) 3 44 58
Products for ABCG4 Gene
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- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ABCG4
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 52 available ABCG4 Antibodies ranked by validation data
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Sources for ABCG4 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
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