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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ABCG4 Gene

protein-coding   GIFtS: 54
GCID: GC11P119019

ATP-binding cassette, sub-family G (WHITE), member 4
 Explore 14 diseases affiliated with
ABCG4 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ABCG4    

Aliases
for ABCG4 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
ATP-Binding Cassette, Sub-Family G (WHITE), Member 41 2
WHITE21 2 3 5
ATP-Binding Cassette Sub-Family G Member 42
ATP-Binding Cassette, Subfamily G, Member 42
Putative ABC Transporter2

External Ids:    HGNC: 138841   Entrez Gene: 641372   Ensembl: ENSG000001723507   OMIM: 6077845   UniProtKB: Q9H1723   

Export aliases for ABCG4 gene to outside databases

Previous GC identifers: GC11P135476 GC11P120533 GC11P119054 GC11P118557 GC11P118558 GC11P118524 GC11P114959


Summaries
for ABCG4 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ABCG4:
The protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC
proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven
distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily
and is expressed predominantly in liver tissue. The function has not yet been determined but may involve cholesterol
transport. Alternate splice variants have been described but their full length sequences have not been determined.
(provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: ABCG4_HUMAN, Q9H172
Function: May be involved in macrophage lipid homeostasis

Gene Wiki entry for ABCG4


Genomic Views
for ABCG4 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.1  NT_033899.8  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ABCG4 gene promoter:
         GR   p300   GR-alpha   GATA-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ABCG4 promoter sequence
   Search SABiosciences Chromatin IP Primers for ABCG4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ABCG4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q23.3   Ensembl cytogenetic band:  11q23.3   HGNC cytogenetic band: 11q23

ABCG4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ABCG4 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P119019:  view genomic region     (about GC identifiers)

Start:
 119,019,722 bp from pter      End:
 119,033,375 bp from pter
Size:
 13,654 bases      Orientation:
 plus strand

Proteins
for ABCG4 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ABCG4_HUMAN, Q9H172 (See protein sequence)
Recommended Name: ATP-binding cassette sub-family G member 4  
Size: 646 amino acids; 71896 Da
Subcellular location: Membrane; Multi-pass membrane protein (Probable)
Secondary accessions: A8K1B5

Explore the universe of human proteins at neXtProt for ABCG4: NX_Q9H172

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9H172

    • ABCG4 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001135977.1  NP_071452.2  

    ENSEMBL proteins: 
     ENSP00000304111   ENSP00000431915   ENSP00000406874   ENSP00000434318   ENSP00000434571  
    Reactome Protein details: Q9H172
    Human Recombinant Protein Products: 
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for ABCG4

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral to membrane IEA--


    ABCG4 for ontologies           About GeneDecksing



    ABCG4 Antibody Products: 
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    Uscn ELISAs and CLIAs for ABCG4

    Protein Domains /
    Families
    for ABCG4 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ABCG4 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR020064 ABC_transptr_G1-like
     IPR003439 ABC_transporter-like
     IPR003593 AAA+_ATPase
     IPR013525 ABC_2_trans
     IPR017871 ABC_transporter_CS

    Graphical View of Domain Structure for InterPro Entry Q9H172

    ProtoNet protein and cluster: Q9H172

    UniProtKB/Swiss-Prot: ABCG4_HUMAN, Q9H172
    Similarity: Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204)
    subfamily
    Similarity: Contains 1 ABC transmembrane type-2 domain
    Similarity: Contains 1 ABC transporter domain


    Function
    for ABCG4 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: ABCG4_HUMAN, Q9H172
    Function: May be involved in macrophage lipid homeostasis

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ABCG4
    8/64 QIAGEN miScript miRNA Assays for microRNAs that regulate ABCG4 (see all 64):
    hsa-miR-142-5p hsa-miR-1321 hsa-miR-15a hsa-miR-106a hsa-miR-605 hsa-miR-25 hsa-miR-346 hsa-miR-218
    SwitchGear 3'UTR luciferase reporter plasmid: ABCG4 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ABCG4 (see all 7)
    OriGene shRNA RFP: ABCG4
    OriGene siRNA: ABCG4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ABCG4

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for ABCG4

    Clone
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    Cell Line
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    Search LifeMap BioReagents cell lines for ABCG4

    In Situ Assay
    Products:       
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    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005524ATP binding IEA--
    GO:0016887ATPase activity IEA--
    GO:0017127cholesterol transporter activity TAS--
    GO:0042803protein homodimerization activity IDA16870176
    GO:0046982protein heterodimerization activity IPI16870176


    ABCG4 for ontologies           About GeneDecksing


    Animal Models:
         2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Abcg4):
     cellular  homeostasis/metabolism 

    ABCG4 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for ABCG4 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1ABC-family proteins mediated transport
    		ABC-family proteins mediated transport1.00
    		ABCA transporters in lipid homeostasis0.47
    		ABC transporters0.70
    2SLC-mediated transmembrane transport
    		Transmembrane transport of small molecules0.50

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    3        Reactome Pathways for ABCG4
        ABC-family proteins mediated transport
    ABCA transporters in lipid homeostasis
    Transmembrane transport of small molecules


    1         Kegg Pathway  (Kegg details for ABCG4):
        ABC transporters


    ABCG4 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ABCG4

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    5/26 Interacting proteins for ABCG4 (Q9H1722, 3 ENSP000003041114) via UniProtKB, MINT, STRING, and/or I2D (see all 26)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AP3D1O146173I2D: score=1 
    ASXL2Q76L833I2D: score=1 
    CBX5P459733I2D: score=1 
    CBX8Q9HC523I2D: score=1 
    CSTF3Q129963I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0033344cholesterol efflux TAS16682745
    GO:0055085transmembrane transport TAS--


    ABCG4 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ABCG4 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ABCG4 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ABCG4
    1 Novoseek chemical compound relationship for ABCG4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cholesterol 0 2 11856881 (2)

    Search CenterWatch for drugs/clinical trials and news about ABCG4 

    Transcripts
    for ABCG4 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ABCG4 gene (2 alternative transcripts): 
    NM_001142505.1  NM_022169.4  

    Unigene Cluster for ABCG4:

    ATP-binding cassette, sub-family G (WHITE), member 4
    Hs.126378  [show with all ESTs]
    Unigene Representative Sequence: NM_022169
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000307417(uc001pvs.3 uc009zar.3) ENST00000524604 ENST00000449422
    ENST00000531739 ENST00000533694 ENST00000534402

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ABCG4
    8/64 QIAGEN miScript miRNA Assays for microRNAs that regulate ABCG4 (see all 64):
    hsa-miR-142-5p hsa-miR-1321 hsa-miR-15a hsa-miR-106a hsa-miR-605 hsa-miR-25 hsa-miR-346 hsa-miR-218
    SwitchGear 3'UTR luciferase reporter plasmid: ABCG4 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ABCG4 (see all 7)
    OriGene shRNA RFP: ABCG4
    OriGene siRNA: ABCG4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ABCG4
    Clone
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): ABCG4 (NM_022169)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ABCG4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ABCG4 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ABCG4
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ABCG4
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ABCG4
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ABCG4

    Additional cDNA sequence: 

    AJ300465.1 AJ308237.1 AJ308238.1 AJ308239.1 AJ308240.1 AJ308242.1 AJ308243.1 AJ308244.1 
    AJ308245.1 AJ308246.1 AJ308247.1 AJ308248.1 AJ308249.1 AJ308250.1 AJ308251.1 AK289830.1 
    AK290035.1 AK308673.1 AL137563.1 BC041091.1 

    2 DOTS entries:

    DT.40126479  DT.120679650 

    23 AceView cDNA sequences:

    AJ308245 AJ308250 AJ308240 BC041091 BQ636356 AJ308243 AJ300465 AJ308246 
    AL137563 AJ308247 AJ308242 NM_022169 AJ308238 AJ308248 AJ308249 AJ308244 
    AJ308251 AJ308237 AA912226 BM925745 BM692180 BX332307 AJ308239 

    GeneLoc Exon Structure


    Expression
    for ABCG4 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ABCG4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TCTGGCTTTC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    ABCG4 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LiverLiver LobuleLiver
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Definitive endoderm-like cells (A scalable, suspensi...)

    See ABCG4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ABCG4

    SOURCE GeneReport for Unigene cluster: Hs.126378
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    In Situ
    Assay Products:     
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    Orthologs
    for ABCG4 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ABCG4 gene from 7/28 species (see all 28)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves ABCG41 ATP-binding cassette, sub-family G (WHITE), member 4 less 81.71(n)
    87.42(a)    		   428242  XM_425801.3  XP_425801.3 
    lizard
    (Anolis carolinensis)    		 Reptilia ABCG46
    		 --
    		 85(a)
    		 1 ↔ 1
    		 GL343722.1(51579-88432)
    zebrafish
    (Danio rerio)    		 Actinopterygii abcg41 ATP-binding cassette, sub-family G (WHITE), member 4 less 73.23(n)
    80.47(a)    		   564842  XM_682593.3  XP_687685.2 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Atet3 ATP-binding cassette (ABC) transporter 62(a)
    (best of 9)    		     --
    worm
    (Caenorhabditis elegans)    		 Secernentea F02E11.13
    wht-41    		 ABC transpoter3
    Protein WHT-41    		 30(a)
    (best of 7)3
    48.1(n)1
    33.64(a)1    		   II(3279207-3281668)3
    1736711  NM_062094.21  NP_494495.21 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT4G274201 ABC transporter G family member 9 43.39(n)
    34.04(a)    		   828850  NM_118876.4  NP_194472.3 
    rice
    (Oryza sativa)    		 Liliopsida Os.72322 Oryza sativa (japonica cultivar-group) cDNA cloneJ023051G10, full insert sequence less 75.12(n)    AK068591.1 


    ENSEMBL Gene Tree for ABCG4 (if available)
    TreeFam Gene Tree for ABCG4 (if available) 

    Paralogs
    for ABCG4 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ABCG4 gene
    ABCG12  ABCA12  ABCA102  ABCA132  ABCA32  ABCA82  ABCA122  ABCG82  
    ABCA42  ABCA72  ABCG52  ABCA22  ABCA92  ABCA62  ABCA52  ABCG22  
    5 SIMAP similar genes for ABCG4 using alignment to 6 protein entries:     ABCG4_HUMAN (see all proteins):
    DKFZp434P1420    white    ABCG1    ABCB4    ABCG2

    ABCG4 for paralogs           About GeneDecksing



    Genomic Variants
    for ABCG4 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    9 NCBI SNPs in ABCG4 are shown     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 11 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1457063371,2
    		C,--119030092(+) CTGGG-/GG    
       CAATA    ACCCT     		2 -- int10--------
    rs613136471,2
    		C,--119030098(+) GCAAT-/AACCCTA 1 -- int10--------
    rs721774811,2
    		----119030093(+) TGGGG-/GC    
       AATAA    CCCTA     		1 -- int10--------
    rs2012655061,2
    		----119030099(+) CAATAA/TCCCTA 1 -- int10--------
    rs710480471,2
    		----119018231(-) ACTTTCTTCTT  
     CCTTC    /-    CTTTC     		1 -- us2k11Minor allele frequency- -:0.00NA 2
    rs1408182851,2
    		----119030096(+) GGGCAA/GTAACC 1 -- int10--------
    rs1998837451,2
    		----119030094(+) GGGGGA/CAATAA 1 -- int10--------
    rs1509496961,2
    		----119030090(+) TACTG-/GGGGC 
                CAATA     		2 -- int10--------
    rs669804271,2
    		----119030088(+) GCTAC-/TG    
       GGGGC    AATAA     		2 -- int10--------

    HapMap Linkage Disequilibrium report for ABCG4 (119019722 - 119033375 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for ABCG4: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ABCG4
    DNA2.0 Custom Variant and Variant Library Synthesis for ABCG4

    Disorders / Diseases
    for ABCG4 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ABCG4 for disorders           About GeneDecksing

    OMIM gene information: 607784    OMIM disorders: --

    14 diseases for ABCG4:    About MalaCards
    cone-rod dystrophy    dubin-johnson syndrome    clostridium difficile    cholesterol
    tangier disease    zellweger syndrome    cystic fibrosis    adrenoleukodystrophy
    down syndrome    fibrosis    atherosclerosis    pneumonia
    tuberculosis    mycobacterium tuberculosis

    4 diseases from the University of Copenhagen DISEASES database for ABCG4:
    Adrenoleukodystrophy     Tangier disease     Atherosclerosis     Retinal degeneration
    Human Genome Epidemiology (HuGE) Navigator: ABCG4 (6 documents)

    Export disorders for ABCG4 gene to outside databases

    Publications
    for ABCG4 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ABCG4 gene, integrated from 9 sources (see all 41):
    (articles sorted by number of sources associating them with ABCG4)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. ABCG4: a novel human white family ABC-transporter expressed in the brain and eye. (PubMed id 12183068)1, 2 Oldfield S.... Lightman S. (2002)
    3. The human ATP-binding cassette (ABC) transporter supe rfamily. (PubMed id 11435397)1, 3 Dean M....Allikmets R. (2001)
    4. The human ABCG4 gene is regulated by oxysterols and retinoids in monocyte-derived macrophages. (PubMed id 11606068)1, 2 Engel T.... Assmann G. (2001)
    5. Human and mouse orthologs of a new ATP-binding cassette gene, ABCG4. (PubMed id 11856881)1, 9 Annilo T....Allikmets R. (2001)
    6. ABCG2- and ABCG4-mediated efflux of amyloid-b peptide 1-40 at the mouse blood-brain barrier. (PubMed id 22391220)1 Do T.M....Bourasset F. (2012)
    7. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1 Bailey S.D....Anand S. (2010)
    8. Integrative predictive model of coronary artery calci fication in atherosclerosis. (PubMed id 19948975)1 McGeachie M....Ramoni M.F. (2009)
    9. Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects. (PubMed id 19343046)1 Saito A....Kamatani N. (2009)
    10. Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)

    External Searches for ABCG4 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing ABCG4 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 64137 HGNC: 13884 AceView: ABCG4 Ensembl:ENSG00000172350 euGenes: HUgn64137
    ECgene: ABCG4 Kegg: 64137 H-InvDB: ABCG4

    Other Databases showing ABCG4 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ABCG4 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ABCG4 Pharmacogenomics, SNPs, Pathways
    ABCMdbhttp://abcmutations.hegelab.org/proteinDetails?uniprot_id=Q9H172

    Intellectual Property
    for ABCG4 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ABCG4 gene:
    Search GeneIP for patents involving ABCG4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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