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ABCG4 Gene

protein-coding   GIFtS: 56
GCID: GC11P119019

ATP-Binding Cassette, Sub-Family G (WHITE), Member 4

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
ATP-Binding Cassette, Sub-Family G (WHITE), Member 41 2     Member 41
WHITE22 3 5     Subfamily G1
Putative ABC Transporter1 2     ATP-Binding Cassette Sub-Family G Member 42
ATP-Binding Cassette1     ATP-Binding Cassette, Subfamily G, Member 42

External Ids:    HGNC: 138841   Entrez Gene: 641372   Ensembl: ENSG000001723507   OMIM: 6077845   UniProtKB: Q9H1723   

Export aliases for ABCG4 gene to outside databases

Previous GC identifers: GC11P135476 GC11P120533 GC11P119054 GC11P118557 GC11P118558 GC11P118524 GC11P114959


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ABCG4 Gene:
The protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC
proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven
distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White
subfamily and is expressed predominantly in liver tissue. The function has not yet been determined but may
involve cholesterol transport. Alternate splice variants have been described but their full length sequences have
not been determined. (provided by RefSeq, Jul 2008)

GeneCards Summary for ABCG4 Gene:
ABCG4 (ATP-binding cassette, sub-family G (WHITE), member 4) is a protein-coding gene. GO annotations related to this gene include ATPase activity and protein homodimerization activity. An important paralog of this gene is ABCG1.

UniProtKB/Swiss-Prot: ABCG4_HUMAN, Q9H172
Function: May be involved in macrophage lipid homeostasis

Gene Wiki entry for ABCG4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NC_018922.2  NT_033899.9  
Regulatory elements:
   Regulatory transcription factor binding sites in the ABCG4 gene promoter:
         GR   p300   GR-alpha   GATA-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidABCG4 promoter sequence
   Search Chromatin IP Primers for ABCG4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ABCG4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q23.3   Ensembl cytogenetic band:  11q23.3   HGNC cytogenetic band: 11q23

ABCG4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ABCG4 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P119019:  view genomic region     (about GC identifiers)

Start:
119,019,722 bp from pter      End:
119,033,375 bp from pter
Size:
13,654 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ABCG4_HUMAN, Q9H172 (See protein sequence)
Recommended Name: ATP-binding cassette sub-family G member 4  
Size: 646 amino acids; 71896 Da
Secondary accessions: A8K1B5

Explore the universe of human proteins at neXtProt for ABCG4: NX_Q9H172

Explore proteomics data for ABCG4 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ABCG4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001135977.1  NP_071452.2  

    ENSEMBL proteins: 
     ENSP00000304111   ENSP00000431915   ENSP00000406874   ENSP00000434318   ENSP00000434571  
    Reactome Protein details: Q9H172

    ABCG4 Human Recombinant Protein Products:

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    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ABCG4

     
    Search eBioscience for Proteins for ABCG4 

     
    antibodies-online proteins for ABCG4 (2 products) 

     
    antibodies-online peptides for ABCG4

    ABCG4 Antibody Products:

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    antibodies-online antibodies for ABCG4 (32 products) 

    ABCG4 Assay Products:

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    Cloud-Clone Corp. ELISAs for ABCG4
    Cloud-Clone Corp. CLIAs for ABCG4
    Search eBioscience for ELISAs for ABCG4 
    antibodies-online kits for ABCG4 (2 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ABCG: ATP binding cassette transporters / subfamily G

    IUPHAR Guide to PHARMACOLOGY protein family classification: ABCG4
    ABCG subfamily

    5 InterPro protein domains:
     IPR003439 ABC_transporter-like
     IPR027417 P-loop_NTPase
     IPR003593 AAA+_ATPase
     IPR013525 ABC_2_trans
     IPR017871 ABC_transporter_CS

    Graphical View of Domain Structure for InterPro Entry Q9H172

    ProtoNet protein and cluster: Q9H172

    UniProtKB/Swiss-Prot: ABCG4_HUMAN, Q9H172
    Similarity: Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204)
    subfamily
    Similarity: Contains 1 ABC transmembrane type-2 domain
    Similarity: Contains 1 ABC transporter domain


    Find genes that share domains with ABCG4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ABCG4_HUMAN, Q9H172
    Function: May be involved in macrophage lipid homeostasis

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding ----
    GO:0005515protein binding IPI16870176
    GO:0005524ATP binding IEA--
    GO:0016887ATPase activity IEA--
    GO:0017111nucleoside-triphosphatase activity ----
         
    Find genes that share ontologies with ABCG4           About GenesLikeMe


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Abcg4):
     cellular  homeostasis/metabolism 

    Find genes that share phenotypes with ABCG4           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for ABCG4

    miRNA
    Products:
        
    miRTarBase miRNAs that target ABCG4:
    hsa-mir-26b-5p (MIRT030047)

    Block miRNA regulation of human, mouse, rat ABCG4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ABCG4 (see all 64):
    hsa-miR-142-5p hsa-miR-1321 hsa-miR-15a hsa-miR-106a hsa-miR-605 hsa-miR-25 hsa-miR-346 hsa-miR-218
    SwitchGear 3'UTR luciferase reporter plasmidABCG4 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ABCG4

    Gene Editing
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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ABCG4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ABCG4_HUMAN, Q9H172: Membrane; Multi-pass membrane protein (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    peroxisome2
    endoplasmic reticulum1
    endosome1
    extracellular1
    nucleus1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016020membrane ----
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with ABCG4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ABCG4 About    
    See pathways by source

    SuperPathContained pathways About
    1ABC-family proteins mediated transport
    ABC-family proteins mediated transport0.69
    ABCA transporters in lipid homeostasis0.00
    ABC transporters0.69
    2Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    Transmembrane transport of small molecules0.47


    Find genes that share SuperPaths with ABCG4           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for ABCG4
        ABCA transporters in lipid homeostasis


    1 Kegg Pathway  (Kegg details for ABCG4):
        ABC transporters

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ABCG4
    Interactions:

        Search GeneGlobe Interaction Network for ABCG4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ABCG4 (Q9H1721, 2, 3 ENSP000003041114) via UniProtKB, MINT, STRING, and/or I2D (see all 94)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AP3D1O146173, ENSP000003440554I2D: score=1 STRING: ENSP00000344055
    CSTF3Q129963, ENSP000003157914I2D: score=1 STRING: ENSP00000315791
    EEDO755303, ENSP000002633604I2D: score=1 STRING: ENSP00000263360
    MTF2Q9Y4833, ENSP000003593214I2D: score=1 STRING: ENSP00000359321
    REREQ9P2R63, ENSP000003386294I2D: score=1 STRING: ENSP00000338629
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0033344cholesterol efflux TAS16682745
    GO:0055085transmembrane transport TAS--

    Find genes that share ontologies with ABCG4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ABCG4

    1 Novoseek inferred chemical compound relationship for ABCG4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cholesterol 0 2 11856881 (2)



    Find genes that share compounds with ABCG4           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ABCG4 gene (2 alternative transcripts): 
    NM_001142505.1  NM_022169.4  

    Unigene Cluster for ABCG4:

    ATP-binding cassette, sub-family G (WHITE), member 4
    Hs.126378  [show with all ESTs]
    Unigene Representative Sequence: NM_022169
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000307417(uc001pvs.3 uc009zar.3) ENST00000524604 ENST00000449422
    ENST00000531739 ENST00000533694 ENST00000534402
    miRNA
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    Block miRNA regulation of human, mouse, rat ABCG4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ABCG4 (see all 64):
    hsa-miR-142-5p hsa-miR-1321 hsa-miR-15a hsa-miR-106a hsa-miR-605 hsa-miR-25 hsa-miR-346 hsa-miR-218
    SwitchGear 3'UTR luciferase reporter plasmidABCG4 3' UTR sequence
    Inhib. RNA
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    Primer
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    OriGene qPCR primer pairs and template standards for ABCG4
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      QuantiTect SYBR Green Assays in human, mouse, rat ABCG4
      QuantiFast Probe-based Assays in human, mouse, rat ABCG4

    Additional mRNA sequence: 

    AJ300465.1 AJ308237.1 AJ308238.1 AJ308239.1 AJ308240.1 AJ308242.1 AJ308243.1 AJ308244.1 
    AJ308245.1 AJ308246.1 AJ308247.1 AJ308248.1 AJ308249.1 AJ308250.1 AJ308251.1 AK289830.1 
    AK290035.1 AK308673.1 AL137563.1 BC041091.1 

    2 DOTS entries:

    DT.40126479  DT.120679650 

    23 AceView cDNA sequences:

    AJ308238 AJ308243 AJ308240 AJ308246 AJ308247 NM_022169 AJ308248 AL137563 
    BC041091 BQ636356 AJ308242 AJ308245 AJ300465 AJ308250 AJ308237 AJ308244 
    AJ308249 AJ308251 AA912226 BM925745 BM692180 BX332307 AJ308239 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ABCG4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCTGGCTTTC
    ABCG4 Expression
    About this image


    ABCG4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Liver (Hepatobiliary System)
             Liver Lobule
     
     Blood (Hematopoietic System)
             Proerythroblasts Hematopoietic Bone Marrow
     
     Neural Tube (Nervous System)
             Telencephalon
     
     Brain (Nervous System)
             Cerebral Cortex
    ABCG4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ABCG4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.126378
        Custom PCR Arrays for ABCG4
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ABCG4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ABCG4 gene from Selected species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Abcg41 , 5 ATP-binding cassette, sub-family G (WHITE), member 4 less1, 5 90.25(n)1
    96.59(a)1
      9 (24.84 cM)5
    1926631  NM_138955.31  NP_620405.31 
     442731885 
    chicken
    (Gallus gallus)
    Aves ABCG41 ATP-binding cassette, sub-family G (WHITE), member 4 less 81.71(n)
    87.26(a)
      428242  XM_004948047.1  XP_004948104.1 
    lizard
    (Anolis carolinensis)
    Reptilia ABCG46
    ATP-binding cassette, sub-family G (WHITE), member...
    87(a)
    1 ↔ 1
    GL343722.1(47680-93838)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia abcg41 ATP-binding cassette, sub-family G (WHITE), member 4 less 71.6(n)
    83.62(a)
      101734071  XM_004916052.1  XP_004916109.1 
    zebrafish
    (Danio rerio)
    Actinopterygii abcg41 ATP-binding cassette, sub-family G (WHITE), member 4 less 73.46(n)
    80.72(a)
      564842  XM_682593.4  XP_687685.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta Atet1 , 3 ATP-binding cassette (ABC) transporter3
    ABC transporter expressed in trachea1
    62(a)
    (best of 9)3
    62.83(n)1
    59.53(a)1
      336361  NM_001103608.21  NP_001097078.11 
    worm
    (Caenorhabditis elegans)
    Secernentea F02E11.13 ABC transpoter 30(a)
    (best of 7)
      II(3279207-3281668)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ADP16
    Putative ATP-dependent permease of the ABC transpo...
    16(a)
    1 → many
    III(133724-136873) YCR011C
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT4G274201 AT4G27420 43.06(n)
    34.17(a)
      828850  NM_118876.4  NP_194472.3 
    rice
    (Oryza sativa)
    Liliopsida Os.72322 Oryza sativa (japonica cultivar-group) cDNA cloneJ023051G10, full insert sequence less 75.12(n)    AK068591.1 


    ENSEMBL Gene Tree for ABCG4 (if available)
    TreeFam Gene Tree for ABCG4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ABCG4 gene
    ABCG12  ABCG82  ABCG52  ABCG22  
    5 SIMAP similar genes for ABCG4 using alignment to 6 protein entries:     ABCG4_HUMAN (see all proteins):
    DKFZp434P1420    white    ABCG1    ABCB4    ABCG2

    Find genes that share paralogs with ABCG4           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ABCG4 (see all 404)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1903626341,2
    --114957265(+) GCCTGC/TAATCA 1 -- us2k10--------
    rs1393350791,2
    --114957274(+) CACAGC/TACTTT 1 -- us2k10--------
    rs1820596851,2
    --114957313(+) GGTCAG/TGAATT 1 -- us2k10--------
    rs11688151,2
    C,F,A--114957438(-) ttgaaG/Acgatt 1 -- us2k16Minor allele frequency- A:0.36NA WA CSA 11
    rs116063231,2
    H--114957547(+) aaagaA/Gagaaa 1 -- us2k1 trp30--------
    rs1426935891,2
    C--114957551(+) GAGAA-/AGAGAG
            
    AGAGA
    1 -- cds10--------
    rs116063251,2
    H--114957559(+) agagaA/Gagaga 1 -- us2k1 trp30--------
    rs116020871,2
    H--114957573(+) aaagaA/Gagaga 1 -- us2k1 trp30--------
    rs3688691381,2
    C--114957589(+) AAGAA-/GGAAAG 1 -- us2k10--------
    rs3777161921,2
    C--114957590(+) gaaag-/A/AAAA
            
    gaaag
    1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ABCG4 (119019722 - 119033375 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for ABCG4:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv468879CNV Loss19166990
    nsv898416CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607784    OMIM disorders: --


    Find genes that share disorders with ABCG4           About GenesLikeMe

    Genetic Association Database (GAD): ABCG4
    Human Genome Epidemiology (HuGE) Navigator: ABCG4 (6 documents)

    Export disorders for ABCG4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ABCG4 gene, integrated from 10 sources (see all 41):
    (articles sorted by number of sources associating them with ABCG4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    2. Integrative predictive model of coronary artery calcification in atherosclerosis. (PubMed id 19948975)1, 4 McGeachie M....Ramoni M.F. (Circulation 2009)
    3. Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects. (PubMed id 19343046)1, 4 Saito A....Kamatani N. (J. Hum. Genet. 2009)
    4. Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations. (PubMed id 18660489)1, 4 Lu Y....Boer J.M. (J. Lipid Res. 2008)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. ABCG4: a novel human white family ABC-transporter expressed in the brain and eye. (PubMed id 12183068)1, 2 Oldfield S.... Lightman S. (Biochim. Biophys. Acta 2002)
    7. The human ATP-binding cassette (ABC) transporter superfamily. (PubMed id 11435397)1, 3 Dean M....Allikmets R. (Genome Res. 2001)
    8. The human ABCG4 gene is regulated by oxysterols and retinoids in monocyte-derived macrophages. (PubMed id 11606068)1, 2 Engel T.... Assmann G. (Biochem. Biophys. Res. Commun. 2001)
    9. Human and mouse orthologs of a new ATP-binding cassette gene, ABCG4. (PubMed id 11856881)1, 9 Annilo T....Allikmets R. (Cytogenet. Cell Genet. 2001)
    10. ABCG2- and ABCG4-mediated efflux of amyloid-I^ peptide 1-40 at the mouse blood-brain barrier. (PubMed id 22391220)1 Do T.M....Bourasset F. (J. Alzheimers Dis. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
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      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 64137 HGNC: 13884 AceView: ABCG4 Ensembl:ENSG00000172350 euGenes: HUgn64137
    ECgene: ABCG4 Kegg: 64137 H-InvDB: ABCG4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ABCG4 Pharmacogenomics, SNPs, Pathways
    ABCMdbhttp://abcmutations.hegelab.org/proteinDetails?uniprot_id=Q9H172

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ABCG4 gene:
    Search GeneIP for patents involving ABCG4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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