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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ABCG2 Gene

protein-coding   GIFtS: 71
GCID: GC04M089011

ATP-binding cassette, sub-family G (WHITE), member 2
 Explore 99 diseases affiliated with
ABCG2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ABCG2    

Aliases
for ABCG2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
ATP-Binding Cassette, Sub-Family G (WHITE), Member 21 2     BMDP2
ABCP1 2 3 5     GOUT12
BCRP1 2 3 5     MRX2
MXR1 2 3     MXR12
CD3381 2     UAQTL12
EST1574811 2     ABC Transporter2
Breast Cancer Resistance Protein2 3     ATP-Binding Cassette Sub-Family G Member 22
Mitoxantrone Resistance-Associated Protein2 3     ATP-Binding Cassette Transporter G22
Placenta-Specific ATP-Binding Cassette Transporter2 3     Multi Drug Resistance Efflux Transport ATP-Binding Cassette Sub-Family G
(WHITE) Member 22
BCRP12 3     Placenta Specific MDR Protein2
CDw3382 3     CD338 Antigen3
ABC152     

External Ids:    HGNC: 741   Entrez Gene: 94292   Ensembl: ENSG000001187777   OMIM: 6037565   UniProtKB: Q9UNQ03   

Export aliases for ABCG2 gene to outside databases

Previous GC identifers: GC04M089170 GC04M089314 GC04M089471 GC04M089370 GC04M089230 GC04M084757


Summaries
for ABCG2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ABCG2:
The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC)
transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are
divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the
White subfamily. Alternatively referred to as a breast cancer resistance protein, this protein functions as a
xenobiotic transporter which may play a major role in multi-drug resistance. It likely serves as a cellular defense
mechanism in response to mitoxantrone and anthracycline exposure. Significant expression of this protein has been
observed in the placenta, which may suggest a potential role for this molecule in placenta tissue. Multiple transcript
variants encoding different isoforms have been found for this gene. (provided by RefSeq, Apr 2012)

UniProtKB/Swiss-Prot: ABCG2_HUMAN, Q9UNQ0
Function: Xenobiotic transporter that may play an important role in the exclusion of xenobiotics from the brain. May be
involved in brain-to-blood efflux. Appears to play a major role in the multidrug resistance phenotype of several
cancer cell lines. When overexpressed, the transfected cells become resistant to mitoxantrone, daunorubicin and
doxorubicin, display diminished intracellular accumulation of daunorubicin, and manifest an ATP-dependent increase in
the efflux of rhodamine 123

summary for ABCG2:
ABCG2 encodes a protein known as breast cancer resistance protein (BCRP). Similar to MRP1 and MDR1, BCRP is
a member of the human ABC transporter family.

Gene Wiki entry for ABCG2


Genomic Views
for ABCG2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_016354.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ABCG2 gene promoter:
         Sp1   AP-1   ATF-2   HNF-1A   PPAR-gamma1   HNF-1   PPAR-gamma2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ABCG2 promoter sequence
   Search SABiosciences Chromatin IP Primers for ABCG2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ABCG2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q22   Ensembl cytogenetic band:  4q22.1   HGNC cytogenetic band: 4q22.1

ABCG2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ABCG2 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M089011:  view genomic region     (about GC identifiers)

Start:
 89,011,416 bp from pter      End:
 89,152,474 bp from pter
Size:
 141,059 bases      Orientation:
 minus strand

Proteins
for ABCG2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ABCG2_HUMAN, Q9UNQ0 (See protein sequence)
Recommended Name: ATP-binding cassette sub-family G member 2  
Size: 655 amino acids; 72314 Da
Subunit: Monomer or homodimer; disulfide-linked
Subcellular location: Cell membrane; Multi-pass membrane protein
Sequence caution: Sequence=AF093771; Type=Frameshift; Positions=486, 586; Sequence=AF093772; Type=Frameshift;
Positions=386, 502, 586;
Secondary accessions: A0A1W3 A8K1T5 O95374 Q53ZQ1 Q569L4 Q5YLG4 Q86V64 Q8IX16 Q96LD6 Q96TA8 Q9BY73
Q9NUS0
Alternative splicing: 2 isoforms:  Q9UNQ0-1   Q9UNQ0-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ABCG2: NX_Q9UNQ0

Post-translational modifications:

  • Glycosylation-deficient ABCG2 is normally expressed and functional1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9UNQ0

    • ABCG2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001244315.1  NP_004818.2  

    ENSEMBL proteins: 
     ENSP00000426917   ENSP00000237612   ENSP00000426916   ENSP00000426934  
    Reactome Protein details: Q9UNQ0
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: ABCG2
    OriGene Custom Protein Services for ABCG2 
    GenScript Custom Purified and Recombinant Proteins Services for ABCG2
    Novus Biologicals ABCG2 Proteins
    Novus Biologicals ABCG2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for ABCG2

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral to membrane IEA--


    ABCG2 for ontologies           About GeneDecksing



    ABCG2 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of ABCG2
    R&D Systems Antibodies for ABCG2
    Cell Signaling Technology (CST) Antibodies for ABCG2 
    OriGene Antibodies: ABCG2
    OriGene Custom Antibody Services for ABCG2 
    GenScript Custom Superior Antibodies Services for ABCG2
    Novus Biologicals ABCG2 Antibodies
    Abcam antibodies for ABCG2 
    Uscn Antibodies for ABCG2
    ThermoFisher Antibody for ABCG2

    Assay Products for ABCG2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ABCG2
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for ABCG2

    Protein Domains /
    Families
    for ABCG2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ABCG2 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR003439 ABC_transporter-like
     IPR003593 AAA+_ATPase
     IPR013525 ABC_2_trans

    Graphical View of Domain Structure for InterPro Entry Q9UNQ0

    ProtoNet protein and cluster: Q9UNQ0

    UniProtKB/Swiss-Prot: ABCG2_HUMAN, Q9UNQ0
    Similarity: Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204)
    subfamily
    Similarity: Contains 1 ABC transmembrane type-2 domain
    Similarity: Contains 1 ABC transporter domain


    Function
    for ABCG2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: ABCG2_HUMAN, Q9UNQ0
    Function: Xenobiotic transporter that may play an important role in the exclusion of xenobiotics from the brain. May be
    involved in brain-to-blood efflux. Appears to play a major role in the multidrug resistance phenotype of several
    cancer cell lines. When overexpressed, the transfected cells become resistant to mitoxantrone, daunorubicin and
    doxorubicin, display diminished intracellular accumulation of daunorubicin, and manifest an ATP-dependent increase in
    the efflux of rhodamine 123
    Induction: Up-regulated in brain tumors

         Genatlas biochemistry entry for ABCG2:
    ATP binding cassette superfamily,subfamily G (WHITE),member 2,multidrug resistance transporter,expressed in the
    placenta,involved in transport of specific molecules into or out the placenta,homolog to Drosophila white and yeast
    ADP1 gene

    miRNA
    Products:            		miRTarBase miRNAs that target ABCG2:
    hsa-mir-192 (MIRT004129), hsa-mir-520h (MIRT001952), hsa-mir-328 (MIRT000081), hsa-mir-519c-3p (MIRT000998)

    OriGene 3'-UTR Clone: ABCG2
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ABCG2
    1 QIAGEN miScript miRNA Assays for microRNA that regulate ABCG2:
    hsa-miR-3163
    SwitchGear 3'UTR luciferase reporter plasmid: ABCG2 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ABCG2 (see all 7)
    OriGene shRNA RFP: ABCG2
    OriGene siRNA: ABCG2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ABCG2

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for ABCG2

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ABCG2 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ABCG2 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: ABCG2 (NM_004827)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ABCG2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ABCG2 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for ABCG2
    Search LifeMap BioReagents cell lines for ABCG2

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ABCG2

    Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005215transporter activity TAS9861027
    GO:0005515protein binding IPI18056989
    GO:0005524ATP binding IEA--
    GO:0008559xenobiotic-transporting ATPase activity TAS9861027
    GO:0015232heme transporter activity TAS--


    ABCG2 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-outs for ABCG2: Abcg2tm1Ahs Abcg2tm1Bsor
         7 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Abcg2):
     hematopoietic system  homeostasis/metabolism  integument  liver/biliary system  nervous system 
     no phenotypic analysis  other 

    ABCG2 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for ABCG2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/21 super-pathways (see all 21) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Irinotecan Pathway, Pharmacokinetics
    		Irinotecan Pathway, Pharmacokinetics1.00
    		Mycophenolic acid Pathway, Pharmacokinetics0.50
    		Irinotecan Pathway0.73
    		Taxane Pathway, Pharmacokinetics0.30
    		Irinotecan Pathway, Pharmacodynamics0.50
    2Gefitinib Pathway, Pharmacokinetics
    		Gefitinib Pathway, Pharmacokinetics1.00
    		Erlotinib Pathway, Pharmacokinetics0.42
    		Imatinib Pathway, Pharmacokinetics/Pharmacodynamics0.58
    3Pravastatin Pathway, Pharmacokinetics
    		Pravastatin Pathway, Pharmacokinetics1.00
    		Methotrexate Pathway (Brain Cell), Pharmacokinetics0.33
    		Methotrexate Pathway, Pharmacokinetics0.47
    4Abacavir transport and metabolism
    		Abacavir transport and metabolism1.00
    		Abacavir transmembrane transport0.50
    5Acetaminophen Pathway, Pharmacokinetics
    		Pathway_PA165986194 -need delete1.00
    		Acetaminophen Pathway, Pharmacokinetics1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for ABCG2
        Selected targets of ESR1


    1 Cell Signaling Technology (CST) Pathway for ABCG2
        Glucose / Energy Metabolism

    4 BioSystems Pathways for ABCG2 
        Fluoropyrimidine Activity
    Irinotecan Pathway
    HIF-1-alpha transcription factor network
    HIF-2-alpha transcription factor network

    5        Reactome Pathways for ABCG2
        Transmembrane transport of small molecules
    Metabolism
    Abacavir transmembrane transport
    Iron uptake and transport
    Abacavir transport and metabolism

    5/20 PharmGKB Pathways for ABCG2 (see all 20)
        Acetaminophen Pathway, Pharmacokinetics
    Doxorubicin Pathway (Cancer Cell), Pharmacodynamics
    Doxorubicin Pathway, Pharmacokinetics
    Erlotinib Pathway, Pharmacokinetics
    Fluoropyrimidine Pathway, Pharmacokinetics

    2         Kegg Pathways  (Kegg details for ABCG2):
        ABC transporters
    Bile secretion


    ABCG2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ABCG2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 23)

    5/32 Interacting proteins for ABCG2 (Q9UNQ01, 2, 3 ENSP000002376124) via UniProtKB, MINT, STRING, and/or I2D (see all 32)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCP0CG482, 3, ENSP000003448184MINT-7265522 MINT-7265536 I2D: score=2 STRING: ENSP00000344818
    CSNK1G2P783683I2D: score=5 
    HSD17B12Q53GQ03I2D: score=2 
    DNAJA1P316893I2D: score=1 
    FA2HQ7L5A83I2D: score=1 
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport TAS9850061
    GO:0006855drug transmembrane transport TAS--
    GO:0006879cellular iron ion homeostasis TAS--
    GO:0015886heme transport TAS--
    GO:0042493response to drug TAS9861027


    ABCG2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ABCG2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ABCG2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Enzo Life Sciences drugs & compounds for ABCG2

    Compounds for ABCG2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Ko 143Potent and selective BCRP inhibitor[461054-93-3]

    10/62 DrugBank Compounds for ABCG2 (see all 62)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    MitoxantroneMitoxanthrone (see all 2)65271-80-9transportersubstrate inhibitor10070941 12533678 19172464 19252303 16434618 19148526 19548284 10493507 19501160 10606239 10485464 14645676 12920197 10777678 10806112 11036110 19782742 14566825 19493273 20307139 11437380 19427995 12649196 19572416 12488537 14500392 19708828
    TopotecanTopotecan Hcl (see all 5)119413-54-6transportersubstrate inhibitor12533678 10912951 10493507 19567673 10777678 11036110 10930538 15059881 20460504 12649196 11309344 15313923
    ImatinibImatinib Mesylate (see all 3)152459-95-5transportersubstrate inhibitor16303243 15970668 20423956 19710702 15805252 19785662 15059881 15918555 15251980 16543472 19708828
    MethotrexateAmethopterin (see all 12)59-05-2transportersubstrate19076159 19232821 12874005 19691360 12741957 19427995 12682043 15313923 14500392
    DoxorubicinDoxorubicin HCl (see all 5)23214-92-8transportersubstrate inhibitor19232821 19390592 11437380 19427995 12682043 12649196 12488537 19708828
    Estrone-- 53-16-7transporterinhibitor15205350 12533678 12920197 14566825 12682043 11927002
    Gefitinib-- 184475-35-2transporterinhibitor19148526 19567673 19493273 15155841 19708828
    Conjugated EstrogensEstrogens (see all 10)438-67-5transportersubstrate12920197 12682043 15901800
    Daunorubicin-- 20830-81-3transportersubstrate14645676 12668685 11437380
    FlavopiridolAlvocidib (see all 5)131740-09-5transportersubstrate19148526 14645676 12960118

    10/136 Novoseek chemical compound relationships for ABCG2 gene (see all 136)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    fumitremorgin c 96.5 89 12477054 (4), 14613996 (4), 10646850 (3), 16490770 (3) (see all 39)
    mitoxantrone 93.3 322 15047700 (5), 18725232 (5), 14613996 (4), 19118611 (4) (see all 99)
    gf 120918 92.1 58 18248513 (3), 10656616 (2), 15716365 (2), 15860656 (2) (see all 28)
    topotecan 89.3 132 14693055 (4), 15608138 (4), 16343180 (4), 11927002 (3) (see all 68)
    pheophorbide a 85.4 15 19131524 (2), 17250810 (2), 17652262 (1), 17518356 (1) (see all 8)
    mk 571 83.4 10 18718123 (1), 18728938 (1), 19421845 (1), 17543436 (1) (see all 9)
    mr20 82.4 4 15788683 (2), 15208643 (1)
    (125i)iodoarylazidoprazosin 82.2 23 16846237 (3), 19132374 (2), 15598974 (1), 18089721 (1) (see all 10)
    sn 38 81.9 16 15027118 (3), 15075385 (2), 15367706 (1), 16108826 (1) (see all 9)
    hoechst 33342 81.6 25 19270533 (1), 20118824 (1), 20203106 (1), 14612912 (1) (see all 21)

    2 PharmGKB related drug/compound annotations for ABCG2 gene
    Drug/compound PharmGKB Annotation
    methotrexateCA  
    rosuvastatinCA  
    About this table

    Search CenterWatch for drugs/clinical trials and news about ABCG2 

    Transcripts
    for ABCG2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ABCG2 gene (2 alternative transcripts): 
    NM_001257386.1  NM_004827.2  

    Unigene Cluster for ABCG2:

    ATP-binding cassette, sub-family G (WHITE), member 2
    Hs.480218  [show with all ESTs]
    Unigene Representative Sequence: NM_004827
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000515655(uc003hrh.3 uc003hrk.1) ENST00000237612(uc003hrf.3 uc003hrg.3 uc003hri.1 uc003hrj.1)
    ENST00000505480 ENST00000503830

    miRNA
    Products:             		 OriGene 3'-UTR Clone: ABCG2
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ABCG2
    1 QIAGEN miScript miRNA Assays for microRNA that regulate ABCG2:
    hsa-miR-3163
    SwitchGear 3'UTR luciferase reporter plasmid: ABCG2 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ABCG2 (see all 7)
    OriGene shRNA RFP: ABCG2
    OriGene siRNA: ABCG2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ABCG2
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ABCG2 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ABCG2 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: ABCG2 (NM_004827)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ABCG2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ABCG2 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ABCG2
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ABCG2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ABCG2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ABCG2

    Additional cDNA sequence: 

    AB051855.1 AB056867.1 AF093771.1 AF093772.1 AF098951.2 AF103796.1 AF151530.1 AF463519.1 
    AK002040.1 AK290000.1 AY017168.1 AY288307.1 AY289766.1 AY333755.1 AY333756.1 BC011032.1 
    BC021281.2 BC092408.1 U66681.1 

    9 DOTS entries:

    DT.100786807  DT.100786806  DT.453150  DT.100713966  DT.100786805  DT.95109698  DT.102824509  DT.91738759 
    DT.95197134 

    24/117 AceView cDNA sequences (see all 117):

    CR621441 C18155 Z45628 BG573081 AF463519 AA933960 BC021281 BE765504 
    AY017168 CD365766 AW270740 N59214 AI805085 AB056867 BM853954 R77787 
    AA227509 AI141242 BX504168 AY288307 AI424453 AB051855 AI687015 F08388 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for ABCG2    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b · 16c
    SP1:                                                                                                                                          
    SP2:                                                                                                        -                                 
    SP3:                                                                                                                                          
    SP4:                          -                                                                                                               
    SP5:                    -                                                                                                                     


    ECgene alternative splicing isoforms for ABCG2

    Expression
    for ABCG2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ABCG2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TACTGGCGAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    ABCG2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    6 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BrainBlood Brain BarrierAdult Endothelial CellsBlood Brain Barrier, Endothelium
    BrainBlood Brain BarrierPostnatal Endothelial CellsBlood Brain Barrier, Endothelium
    BrainChoroid PlexusChoroid Plexus Progenitor CellsChoroid Plexus
    BrainChoroid PlexusMature Choroid Plexus CellsChoroid Plexus
    TrophoblastMural TrophectodermMural Trophectoderm CellsExtraembryonic Tissues
    TestisSeminiferous TubulesSpermatidGerm Cells, Male Gametocytes
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 4 LifeMap Cells 
    NameCategory
    BG01V (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
    Line H1 (WA01) (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
    Mature brain microvascular endothelial cells (Derivation of blood-...)
    Syncytiotrophoblast-like cells (Generation of syncyt...)

    See ABCG2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ABCG2

    SOURCE GeneReport for Unigene cluster: Hs.480218

    UniProtKB/Swiss-Prot: ABCG2_HUMAN, Q9UNQ0
    Tissue specificity: Highly expressed in placenta. Low expression in small intestine, liver and colon

        SABiosciences Expression via Pathway-Focused PCR Arrays including ABCG2: 
              Breast Cancer in human mouse rat
              Drug Transporters in human mouse rat
              Cancer Drug Resistance in human mouse rat
              Stem Cells in human mouse rat

    Primer
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    Orthologs
    for ABCG2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ABCG2 gene from 8/27 species (see all 27)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Abcg21 , 5 ATP-binding cassette, sub-family G (WHITE), member 2 less1, 5 82.47(n)1
    82.11(a)1    		   6 (27.82 cM)5
    263571  NM_011920.31  NP_036050.11 
     585845235 
    chicken
    (Gallus gallus)    		 Aves ABCG21 ATP-binding cassette, sub-family G (WHITE), member 2 less 62.91(n)
    65.38(a)    		   423767  XM_421638.3  XP_421638.3 
    lizard
    (Anolis carolinensis)    		 Reptilia ABCG26
    --
    		 --
    		 70(a)
    45(a)
    		 1 ↔ 1
    possible ortholog
    		 5(45659494-45683333)
    GL343215.1(2269500-2296748)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia Str.82622 Transcribed sequence with weak similarity to protein spQ9UNQ0 (H.sapiens) ABG2_HUMAN ATP-binding cassette, sub-family G, member 2 (Placenta-specific ATP-binding cassette transporter) (Breast cancer resistance protein) less 74(n)    CF272170.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii abcg2a1 ATP-binding cassette, sub-family G (WHITE), member 2a less 63.4(n)
    64.11(a)    		   735312  NM_001042775.1  NP_001036240.1 
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes ADP1(YCR011C)4
    ADP11    		 Putative ATP-dependent permease of the ABC transporter family of proteins less4
    Adp1p1    		 45.91(n)1
    36.26(a)1    		   3(136873-133724)4
    8503691, 4  NP_009937.21, 4 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT5G065301 ABC transporter G family member 22 47.16(n)
    37.96(a)    		   830541  NM_120736.2  NP_568169.1 
    rice
    (Oryza sativa)    		 Liliopsida Os.89002 Oryza sativa (japonica cultivar-group) cDNA cloneJ013047J21, full insert sequence less 67.25(n)    AK066035.1 


    ENSEMBL Gene Tree for ABCG2 (if available)
    TreeFam Gene Tree for ABCG2 (if available) 

    Paralogs
    for ABCG2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ABCG2 gene
    ABCG12  ABCA12  ABCA102  ABCA132  ABCA32  ABCA82  ABCG42  ABCA122  
    ABCG82  ABCA42  ABCA72  ABCG52  ABCA22  ABCA92  ABCA62  ABCA52  
    18/28 SIMAP similar genes for ABCG2 using alignment to 10 protein entries:     ABCG2_HUMAN (see all proteins) (see all similar genes):
    ABCA5    ABCG1    ABCA3 variant protein    ABCG4    ABCA8    ABCG8
    ABCG5    ABCA3    ABCA9    DKFZp686F2450    ABCA10    ABCB11
    ABCC11    ABCA7    ABCC12    ABCA12    ABCB4    ABCA2

    ABCG2 for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for ABCG2
    PGOHUM00000248237 PGOHUM00000251210 PGOHUM00000241127


    Genomic Variants
    for ABCG2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: ABCG2_HUMAN, Q9UNQ0
    Polymorphism: Genetic variations in ABCG2 define the blood group Junior system (JR) [MIM:614490]. Individuals with
    Jr(a-) blood group lack the Jr(a) antigen on their red blood cells. These individuals may have anti-Jr(a) antibodies
    in their serum, which can cause transfusion reactions or hemolytic disease of the fetus or newborn. Although the
    clinical significance of the Jr(a-) blood group has been controversial, severe fatal hemolytic disease of the newborn
    has been reported. The Jr(a-) phenotype has a higher frequency in individuals of Asian descent, compared to those of
    European descent. The Jr(a-) phenotype is inherited as an autosomal recessive trait
    Polymorphism: Genetic variations in ABCG2 influence the variance in serum uric acid concentrations and define the serum
    uric acid concentration quantitative trait locus 1 (UAQTL1) [MIM:138900]. Excess serum accumulation of uric acid can
    lead to the development of gout, a common disorder characterized by tissue deposition of monosodium urate crystals as
    a consequence of hyperuricemia


    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 13 variations for ABCG2
         7 CNVs: 7456 31182 2536 9485 3501 98790 37738
         6 Indels: 46712 12484 40654 62229 27737 42918
    Human Gene Mutation Database (HGMD): ABCG2

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    Disorders / Diseases
    for ABCG2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ABCG2 for disorders           About GeneDecksing

    OMIM gene information: 603756    OMIM disorders: --

    20/99 diseases for ABCG2 (see all 99):    About MalaCards
    breast cancer    persistent fetal circulation syndrome    diffuse large b-cell lymphoma    dysembryoplastic neuroepithelial tumor
    central nervous system lymphoma    cerebral amyloid angiopathy    lichen planus    b-cell lymphomas
    nonpapillary renal cell carcinoma    oral lichen planus    malignant pleural mesothelioma    non-hodgkin lymphoma
    adult acute lymphocytic leukemia    gastrointestinal stromal tumor    intractable epilepsy    megakaryoblastic leukemia
    acute lymphocytic leukemia    placental choriocarcinoma    acute megakaryoblastic leukemia    toxic encephalopathy

    4 diseases from the University of Copenhagen DISEASES database for ABCG2:
    Leukemia     Breast cancer     Lung cancer     Hyperuricemia

    10/54 Novoseek disease relationships for ABCG2 gene (see all 54)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    breast cancer 85.1 618 19035187 (4), 18820913 (4), 11566359 (3), 11948115 (3) (see all 99)
    cancer 65.4 219 19827267 (5), 19642144 (5), 17767037 (4), 16554028 (4) (see all 99)
    aml adult 58.4 11 12393637 (4), 20122734 (2), 16278398 (1), 15541485 (1)
    tumors 47.1 111 19659474 (6), 10825126 (3), 16061644 (3), 15146167 (3) (see all 76)
    choriocarcinoma 44.9 9 16445700 (2), 11566359 (1), 15634651 (1), 19146924 (1) (see all 7)
    nsclc 41.9 63 16520985 (4), 17366786 (4), 12912956 (3), 17534875 (3) (see all 17)
    aml childhood 40.6 3 18228020 (1), 12145683 (1), 20426950 (1)
    leukemia 37.7 14 19635183 (2), 16403267 (1), 19862976 (1), 10720143 (1) (see all 11)
    acute leukemia 34.4 13 14989769 (2), 15160935 (2), 19862976 (1), 20350531 (1) (see all 8)
    neuroepithelial tumors 31.5 1 14636345 (1)

    Genetic Association Database (GAD): ABCG2
    Human Genome Epidemiology (HuGE) Navigator: ABCG2 (112 documents)

    Export disorders for ABCG2 gene to outside databases

    Publications
    for ABCG2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ABCG2 gene, integrated from 9 sources (see all 1019):
    (articles sorted by number of sources associating them with ABCG2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A multidrug resistance transporter from human MCF-7 breast cancer cells. (PubMed id 9861027)1, 2, 3, 9 Doyle L.A....Ross D.D. (1998)
    2. Breast cancer resistance protein and P-glycoprotein l imit sorafenib brain accumulation. (PubMed id 20103600)1, 7, 9 Lagas J.S....Schinkel A.H. (2010)
    3. Detection of single nucleotide polymorphisms in the ABCG2 gene in a Dutch population. (PubMed id 15813675)1, 4, 9 Bosch T.M....Meijerman I. (2005)
    4. Single nucleotide polymorphisms modify the transporter activity of ABCG2. (PubMed id 15838659)1, 2, 9 Morisaki K.... Bates S.E. (2005)
    5. Sterol transport by the human breast cancer resistance protein (ABCG2) expressed in Lactococcus lactis. (PubMed id 12668685)1, 7, 9 Janvilisri T....van Veen H.W. (2003)
    6. Identification and functional characterization of bre ast cancer resistance protein in human bronchial epithelial cells (Calu-3). (PubMed id 19782742)1, 7, 9 Paturi D.K....Mitra A.K. (2010)
    7. Complex interaction of BCRP/ABCG2 and imatinib in BCR-ABL-expressing cells: BCRP-mediated resistance to imatinib is attenuated by imatinib-induced reduction of BCRP expression. (PubMed id 16543472)1, 7, 9 Nakanishi T....Ross D.D. (2006)
    8. Influence of ABCB1, ABCC1, ABCC2, and ABCG2 haplotypes on the cellular exposure of nelfinavir in vivo. (PubMed id 16041239)1, 4, 9 Colombo S....Telenti A. (2005)
    9. Atypical multidrug resistance: breast cancer resistance protein messenger RNA expression in mitoxantrone-selected cell lines. (PubMed id 10070941)1, 7, 9 Ross D.D....Doyle L.A. (1999)
    10. Effects of putative catalytic base mutation E211Q on ABCG2-mediated methotrexate transport. (PubMed id 19691360)1, 7, 9 Hou Y.X....Chang X.B. (2009)

    External Searches for ABCG2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing ABCG2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9429 HGNC: 74 AceView: ABCG2 Ensembl:ENSG00000118777 euGenes: HUgn9429
    ECgene: ABCG2 Kegg: 9429 H-InvDB: ABCG2

    Other Databases showing ABCG2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ABCG2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ABCG2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ABCG2 Genetics and Cytogenetics in Oncology and Haematology
    SeattleSNPshttp://pga.gs.washington.edu/data/abcg2/
    ABCMdbhttp://abcmutations.hegelab.org/proteinDetails?uniprot_id=Q9UNQ0

    Intellectual Property
    for ABCG2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ABCG2 gene:
    Search GeneIP for patents involving ABCG2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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