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Aliases for ABCG2 Gene

Aliases for ABCG2 Gene

  • ATP-Binding Cassette, Sub-Family G (WHITE), Member 2 (Junior Blood Group) 2 3
  • ABCP 3 4 6
  • BCRP 3 4 6
  • Placenta-Specific ATP-Binding Cassette Transporter 3 4
  • Mitoxantrone Resistance-Associated Protein 3 4
  • Breast Cancer Resistance Protein 3 4
  • Urate Exporter 3 4
  • UAQTL1 3 6
  • CDw338 3 4
  • BCRP1 3 4
  • GOUT1 3 6
  • MXR 3 4
  • Multi Drug Resistance Efflux Transport ATP-Binding Cassette Sub-Family G (WHITE) Member 2 3
  • ATP-Binding Cassette, Sub-Family G (WHITE), Member 2 2
  • ATP-Binding Cassette Sub-Family G Member 2 3
  • ATP-Binding Cassette Transporter G2 3
  • Placenta Specific MDR Protein 3
  • ABC Transporter 3
  • CD338 Antigen 4
  • EST157481 3
  • ABC15 3
  • CD338 3
  • BMDP 3
  • MXR1 3
  • MRX 3

External Ids for ABCG2 Gene

Previous GeneCards Identifiers for ABCG2 Gene

  • GC04M089170
  • GC04M089314
  • GC04M089471
  • GC04M089370
  • GC04M089230
  • GC04M089011
  • GC04M084757

Summaries for ABCG2 Gene

Entrez Gene Summary for ABCG2 Gene

  • The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. Alternatively referred to as a breast cancer resistance protein, this protein functions as a xenobiotic transporter which may play a major role in multi-drug resistance. It likely serves as a cellular defense mechanism in response to mitoxantrone and anthracycline exposure. Significant expression of this protein has been observed in the placenta, which may suggest a potential role for this molecule in placenta tissue. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]

GeneCards Summary for ABCG2 Gene

ABCG2 (ATP-Binding Cassette, Sub-Family G (WHITE), Member 2 (Junior Blood Group)) is a Protein Coding gene. Diseases associated with ABCG2 include erythroplakia and choriocarcinoma. Among its related pathways are Metabolism and Glucose / Energy Metabolism. GO annotations related to this gene include protein homodimerization activity and ATPase activity, coupled to transmembrane movement of substances. An important paralog of this gene is ABCG8.

UniProtKB/Swiss-Prot for ABCG2 Gene

  • High-capacity urate exporter functioning in both renal and extrarenal urate excretion. Plays a role in porphyrin homeostasis as it is able to mediates the export of protoporhyrin IX (PPIX) both from mitochondria to cytosol and from cytosol to extracellular space, and cellular export of hemin, and heme. Xenobiotic transporter that may play an important role in the exclusion of xenobiotics from the brain. Appears to play a major role in the multidrug resistance phenotype of several cancer cell lines. Implicated in the efflux of numerous drugs and xenobiotics: mitoxantrone, the photosensitizer pheophorbide, camptothecin, methotrexate, azidothymidine (AZT), and the anthracyclines daunorubicin and doxorubicin.

Tocris Summary for ABCG2 Gene

  • ABCG2 encodes a protein known as breast cancer resistance protein (BCRP). Similar to MRP1 and MDR1, BCRP is a member of the human ABC transporter family.

Gene Wiki entry for ABCG2 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ABCG2 Gene

Genomics for ABCG2 Gene

Regulatory Elements for ABCG2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ABCG2 Gene

Start:
88,090,264 bp from pter
End:
88,231,417 bp from pter
Size:
141,154 bases
Orientation:
Minus strand

Genomic View for ABCG2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ABCG2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ABCG2 Gene

Proteins for ABCG2 Gene

  • Protein details for ABCG2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UNQ0-ABCG2_HUMAN
    Recommended name:
    ATP-binding cassette sub-family G member 2
    Protein Accession:
    Q9UNQ0
    Secondary Accessions:
    • A0A1W3
    • A8K1T5
    • O95374
    • Q4W5I3
    • Q53ZQ1
    • Q569L4
    • Q5YLG4
    • Q86V64
    • Q8IX16
    • Q96LD6
    • Q96TA8
    • Q9BY73
    • Q9NUS0

    Protein attributes for ABCG2 Gene

    Size:
    655 amino acids
    Molecular mass:
    72314 Da
    Quaternary structure:
    • Monomer under reducing conditions, the minimal functional units is a homodimer; disulfide-linked, but the major oligomeric form in plasma membranes is a homotetramer with possibility of higher order oligomerization up to homododecamers.
    Miscellaneous:
    • When overexpressed, the transfected cells become resistant to mitoxantrone, daunorubicin and doxorubicin
    SequenceCaution:
    • Sequence=AF093771; Type=Frameshift; Positions=486, 586; Evidence={ECO:0000305}; Sequence=AF093772; Type=Frameshift; Positions=386, 502, 586; Evidence={ECO:0000305};

    Alternative splice isoforms for ABCG2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ABCG2 Gene

Proteomics data for ABCG2 Gene at MOPED

Post-translational modifications for ABCG2 Gene

  • Glycosylation-deficient ABCG2 is normally expressed and functional.
  • Glycosylation at Asn596
  • Modification sites at PhosphoSitePlus

Other Protein References for ABCG2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for ABCG2 (ABCG2)

No data available for DME Specific Peptides for ABCG2 Gene

Domains for ABCG2 Gene

Gene Families for ABCG2 Gene

HGNC:
  • ABCG :ATP binding cassette transporters / subfamily G
  • CD :CD molecules
IUPHAR :

Protein Domains for ABCG2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UNQ0

UniProtKB/Swiss-Prot:

ABCG2_HUMAN :
  • Q9UNQ0
Domain:
  • The extracellular loop 3 (ECL3) is involved in binding porphyrins and transfer them to other carriers, probably albumin.
  • Contains 1 ABC transmembrane type-2 domain.
  • Contains 1 ABC transporter domain.
Family:
  • Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
genes like me logo Genes that share domains with ABCG2: view

Function for ABCG2 Gene

Molecular function for ABCG2 Gene

GENATLAS Biochemistry:
ATP binding cassette superfamily,subfamily G (WHITE),member 2,multidrug resistance transporter,expressed in the placenta,involved in transport of specific molecules into or out the placenta,homolog to Drosophila white and yeast ADP1 gene
UniProtKB/Swiss-Prot Function:
High-capacity urate exporter functioning in both renal and extrarenal urate excretion. Plays a role in porphyrin homeostasis as it is able to mediates the export of protoporhyrin IX (PPIX) both from mitochondria to cytosol and from cytosol to extracellular space, and cellular export of hemin, and heme. Xenobiotic transporter that may play an important role in the exclusion of xenobiotics from the brain. Appears to play a major role in the multidrug resistance phenotype of several cancer cell lines. Implicated in the efflux of numerous drugs and xenobiotics: mitoxantrone, the photosensitizer pheophorbide, camptothecin, methotrexate, azidothymidine (AZT), and the anthracyclines daunorubicin and doxorubicin.
UniProtKB/Swiss-Prot Induction:
Up-regulated in brain tumors

Gene Ontology (GO) - Molecular Function for ABCG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity TAS 9850061
GO:0005515 protein binding IPI 18056989
GO:0005524 ATP binding IEA --
GO:0008559 xenobiotic-transporting ATPase activity TAS 9861027
GO:0015232 heme transporter activity TAS --
genes like me logo Genes that share ontologies with ABCG2: view
genes like me logo Genes that share phenotypes with ABCG2: view

Animal Models for ABCG2 Gene

MGI Knock Outs for ABCG2:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ABCG2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for ABCG2 Gene

Localization for ABCG2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ABCG2 Gene

Cell membrane; Multi-pass membrane protein. Mitochondrion membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ABCG2 Gene COMPARTMENTS Subcellular localization image for ABCG2 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 2
extracellular 2
nucleus 2
endoplasmic reticulum 1
lysosome 1
mitochondrion 1
vacuole 1

Gene Ontology (GO) - Cellular Components for ABCG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005739 mitochondrion --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane --
genes like me logo Genes that share ontologies with ABCG2: view

Pathways for ABCG2 Gene

genes like me logo Genes that share pathways with ABCG2: view

PCR Array Products

Gene Ontology (GO) - Biological Process for ABCG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006200 obsolete ATP catabolic process --
GO:0006810 transport TAS 9850061
GO:0006855 drug transmembrane transport TAS --
GO:0006879 cellular iron ion homeostasis TAS --
GO:0015886 heme transport TAS --
genes like me logo Genes that share ontologies with ABCG2: view

Compounds for ABCG2 Gene

(5) Tocris Compounds for ABCG2 Gene

Compound Action Cas Number
Fumitremorgin C Inhibitor of BCRP-mediated multidrug resistance [118974-02-0]
Ko 143 Potent and selective BCRP inhibitor [461054-93-3]
Probenecid MRP inhibitor [57-66-9]
PSC 833 Inhibitor of P-gp-mediated MDR [121584-18-7]
Reversan Selective MRP1 and P-gp inhibitor [313397-13-6]

(86) Drugbank Compounds for ABCG2 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Afatinib
850140-72-6 transporter substrate inhibitor
Apixaban
503612-47-3 transporter substrate
Buprenorphine
  • Buprenophine
52485-79-7 transporter inhibitor
Cabazitaxel
  • RPR-116258A
183133-96-2 transporter inhibitor
Camptothecin
  • (+)-camptothecin
7689-03-4 transporter substrate

(136) Novoseek inferred chemical compound relationships for ABCG2 Gene

Compound -log(P) Hits PubMed IDs
fumitremorgin c 96.5 55
mitoxantrone 93.3 161
gf 120918 92.1 39
topotecan 89.3 100
pheophorbide a 85.4 10

(13) PharmGKB related drug/compound annotations for ABCG2 Gene

genes like me logo Genes that share compounds with ABCG2: view

Transcripts for ABCG2 Gene

Unigene Clusters for ABCG2 Gene

ATP-binding cassette, sub-family G (WHITE), member 2:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ABCG2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ABCG2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b · 16c
SP1:
SP2: -
SP3:
SP4: -
SP5: -

Relevant External Links for ABCG2 Gene

GeneLoc Exon Structure for
ABCG2
ECgene alternative splicing isoforms for
ABCG2

Expression for ABCG2 Gene

mRNA expression in normal human tissues for ABCG2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for ABCG2 Gene

This gene is overexpressed in Milk (66.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ABCG2 Gene

SOURCE GeneReport for Unigene cluster for ABCG2 Gene Hs.480218

mRNA Expression by UniProt/SwissProt for ABCG2 Gene

Q9UNQ0-ABCG2_HUMAN
Tissue specificity: Highly expressed in placenta. Low expression in small intestine, liver and colon.
genes like me logo Genes that share expressions with ABCG2: view

Expression partners for ABCG2 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for ABCG2 Gene

Orthologs for ABCG2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ABCG2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ABCG2 35
  • 88.12 (n)
  • 84.56 (a)
ABCG2 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ABCG2 35
  • 86.86 (n)
  • 83.59 (a)
ABCG2 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Abcg2 35
  • 82.47 (n)
  • 82.11 (a)
Abcg2 16
Abcg2 36
  • 82 (a)
OneToMany
Abcg3 36
  • 55 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia ABCG2 35
  • 99.39 (n)
  • 99.39 (a)
ABCG2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Abcg2 35
  • 82.42 (n)
  • 81.5 (a)
oppossum
(Monodelphis domestica)
Mammalia ABCG2 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ABCG2 36
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves ABCG2 35
  • 62.81 (n)
  • 65.33 (a)
ABCG2 36
  • 58 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 61 (a)
OneToMany
-- 36
  • 71 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia abcg2 35
  • 67.31 (n)
  • 73.18 (a)
Str.8262 35
zebrafish
(Danio rerio)
Actinopterygii abcg2a 35
  • 63.3 (n)
  • 64.01 (a)
abcg2a 36
  • 59 (a)
OneToMany
abcg2d 36
  • 55 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2184 35
fruit fly
(Drosophila melanogaster)
Insecta E23 37
  • 38 (a)
st 37
  • 29 (a)
w 37
  • 33 (a)
w 35
  • 44.94 (n)
  • 35.71 (a)
bw 36
  • 24 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta WHITE_ANOGA 35
  • 45.68 (n)
  • 36.38 (a)
worm
(Caenorhabditis elegans)
Secernentea C05D10.3 37
  • 30 (a)
C10C6.5 37
  • 30 (a)
C16C10.12 37
  • 29 (a)
F02E11.1 37
  • 27 (a)
F19B6.4 37
  • 26 (a)
T26A5.1 37
  • 30 (a)
Y47D3A.11 37
  • 29 (a)
wht-7 35
  • 43.42 (n)
  • 32.35 (a)
wht-1 36
  • 29 (a)
ManyToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER190W 35
  • 44.73 (n)
  • 36.6 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D04554g 35
  • 45.43 (n)
  • 33.03 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ADP1 35
  • 46.03 (n)
  • 36.08 (a)
ADP1 36
  • 20 (a)
OneToMany
ADP1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G06530 35
  • 47.25 (n)
  • 38.22 (a)
rice
(Oryza sativa)
Liliopsida Os.8900 35
Os03g0157400 35
  • 46.35 (n)
  • 39.42 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU02544 35
  • 47.49 (n)
  • 37.52 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 46 (a)
OneToOne
Species with no ortholog for ABCG2:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ABCG2 Gene

ENSEMBL:
Gene Tree for ABCG2 (if available)
TreeFam:
Gene Tree for ABCG2 (if available)

Paralogs for ABCG2 Gene

Paralogs for ABCG2 Gene

Pseudogenes.org Pseudogenes for ABCG2 Gene

genes like me logo Genes that share paralogs with ABCG2: view

Variants for ABCG2 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for ABCG2 Gene

Q9UNQ0-ABCG2_HUMAN
Genetic variations in ABCG2 define the blood group Junior system (JR) [MIM:614490]. Individuals with Jr(a-) blood group lack the Jr(a) antigen on their red blood cells. These individuals may have anti-Jr(a) antibodies in their serum, which can cause transfusion reactions or hemolytic disease of the fetus or newborn. Although the clinical significance of the Jr(a-) blood group has been controversial, severe fatal hemolytic disease of the newborn has been reported. The Jr(a-) phenotype has a higher frequency in individuals of Asian descent, compared to those of European descent. The Jr(a-) phenotype is inherited as an autosomal recessive trait

Sequence variations from dbSNP and Humsavar for ABCG2 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs603488 -- 88,184,585(-) ttccg(C/T)gaaca intron-variant
rs1061017 - 88,131,096(+) TCATT(C/G)AAGAG reference, missense
rs1061018 - 88,121,701(-) CTTGT(C/T)CTTGG missense, reference
rs1074839 -- 88,224,396(-) cagtg(A/G)cacca intron-variant
rs1138276 -- 88,091,827(-) TAATA(A/T)ATGAC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ABCG2 Gene

Variant ID Type Subtype PubMed ID
esv2665331 CNV Deletion 23128226
dgv1651e1 CNV Complex 17122850
essv19863 CNV CNV 17122850
nsv4413 CNV Loss 18451855
nsv10531 CNV Gain 18304495
nsv441897 CNV CNV 18776908
esv2452870 CNV Deletion 19546169
esv2381400 CNV Deletion 18987734
esv4251 CNV Deletion 18987735
nsv292910 CNV Loss 16902084
esv7989 CNV Loss 19470904
esv2727950 CNV Deletion 23290073
esv1001700 CNV Deletion 20482838
esv1361477 CNV Deletion 17803354
nsv4414 CNV Insertion 18451855
esv33059 CNV Loss 17666407
nsv818249 CNV Gain 17921354
dgv5641n71 CNV Loss 21882294
nsv879530 CNV Loss 21882294
nsv509009 CNV Insertion 20534489

Relevant External Links for ABCG2 Gene

HapMap Linkage Disequilibrium report
ABCG2
Human Gene Mutation Database (HGMD)
ABCG2

Disorders for ABCG2 Gene

(2) OMIM Diseases for ABCG2 Gene (603756)

(5) University of Copenhagen DISEASES for ABCG2 Gene

(54) Novoseek inferred disease relationships for ABCG2 Gene

Disease -log(P) Hits PubMed IDs
breast cancer 85.1 172
cancer 65.4 140
aml adult 58.4 8
tumors 47.1 98
choriocarcinoma 44.9 8

Relevant External Links for ABCG2

Genetic Association Database (GAD)
ABCG2
Human Genome Epidemiology (HuGE) Navigator
ABCG2
genes like me logo Genes that share disorders with ABCG2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ABCG2 Gene

Publications for ABCG2 Gene

  1. A multidrug resistance transporter from human MCF-7 breast cancer cells. (PMID: 9861027) Doyle L.A. … Ross D.D. (Proc. Natl. Acad. Sci. U.S.A. 1998) 2 3 4 23
  2. Identification of breast cancer resistant protein/mitoxantrone resistance/placenta-specific, ATP-binding cassette transporter as a transporter of NB-506 and J-107088, topoisomerase I inhibitors with an indolocarbazole structure. (PMID: 11306452) Komatani H. … Nishimura S. (Cancer Res. 2001) 3 4 23
  3. The expression and functional characterization of ABCG2 in brain endothelial cells and vessels. (PMID: 12958161) Zhang W. … Stanimirovic D.B. (FASEB J. 2003) 3 4 23
  4. Characterization of oligomeric human half-ABC transporter ATP-binding cassette G2. (PMID: 15001581) Xu J. … Zhang J.T. (J. Biol. Chem. 2004) 3 4 23
  5. Single amino acid (482) variants of the ABCG2 multidrug transporter: major differences in transport capacity and substrate recognition. (PMID: 15670731) Oezvegy-Laczka C. … Varadi A. (Biochim. Biophys. Acta 2005) 3 4 23

Products for ABCG2 Gene

  • Addgene plasmids for ABCG2

Sources for ABCG2 Gene

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