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ABCG2 Gene

protein-coding GIFtS: 75

GC04M089314

ATP-binding cassette, sub-family G (WHITE), member 2
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
ABC15 ^²
ABCP ^¹, ², ³, ⁵
BCRP ^¹, ², ³, ⁵
BCRP1 ^², ³
BMDP ^²
CD338 ^¹, ²
CDw338 ^², ³
EST157481 ^¹, ²
MGC102821 ^²
MRX ^²
MXR ^¹, ², ³
MXR1 ^²

Descriptions
ABC transporter ^²
ATP-binding cassette transporter G2 ^²
ATP-binding cassette, sub-family G (WHITE), member 2 ^²
ATP-binding cassette, sub-family G, member 2 ^²
Breast cancer resistance protein ^², ³
CD338 antigen ^³
Mitoxantrone resistance-associated protein ^³
Placenta-specific ATP-binding cassette transporter ^³
mitoxantrone resistance protein ^²
placenta specific MDR protein ^²

External Ids
HGNC: 74¹
Entrez Gene: 9429²
UniProtKB: Q9UNQ0³
Ensembl: ENSG00000118777⁷

Search outside databases for aliases for ABCG2 gene

Previous GC identifers: GC04M089170 GC04M089471 GC04M089370

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for ABCG2:

The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding

cassette (ABC) transporters. ABC proteins transport various molecules across extra- and

intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP,

MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. Alternatively

referred to as a breast cancer resistance protein, this protein functions as a xenobiotic

transporter which may play a major role in multi-drug resistance. It likely serves as a cellular

defense mechanism in response to mitoxantrone and anthracycline exposure. Significant expression

of this protein has been observed in the placenta, which may suggest a potential role for this

molecule in placenta tissue. [provided by RefSeq]

UniProtKB/Swiss-Prot: ABCG2_HUMAN, Q9UNQ0

Function: Xenobiotic transporter that may play an important role in the exclusion of xenobiotics

from the brain. May be involved in brain-to-blood efflux. Appears to play a major role in the

multidrug resistance phenotype of several cancer cell lines. When overexpressed, the transfected

cells become resistant to mitoxantrone, daunorubicin and doxorubicin, display diminished

intracellular accumulation of daunorubicin, and manifest an ATP-dependent increase in the efflux

of rhodamine 123

Gene Wiki entry for ABCG2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ABCG2 gene

Entrez Gene cytogenetic band: 4q22 Ensembl cytogenetic band: 4q22.1 HGNC cytogenetic band: 4q22-q23

ABCG2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 4 GeneLoc Exon Structure

GeneLoc location for GC04M089314: (about GC identifiers)

Start:	89,230,440 bp from pter
End:	89,299,035 bp from pter
Size:	68,596 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000004.10 NT_016354.18

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: ABCG2_HUMAN, Q9UNQ0 (See protein sequence)

Recommended Name: ATP-binding cassette sub-family G member 2

Size: 655 amino acids; 72314 Da

Subunit: Monomer or homodimer; disulfide-linked

Subcellular location: Cell membrane; Multi-pass membrane protein

Sequence caution: Sequence=AF093771; Type=Frameshift; Positions=486, 586; Sequence=AF093772;

Type=Frameshift; Positions=386, 502, 586;

Secondary accessions: A0A1W3 A8K1T5 O95374 Q53ZQ1 Q569L4 Q5YLG4 Q86V64 Q8IX16 Q96LD6 Q96TA8 Q9BY73

Q9NUS0

Alternative splicing: 2 isoforms: Q9UNQ0-1 Q9UNQ0-2

Post-translational modifications:

Glycosylation-deficient ABCG2 is normally expressed and functional¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_004818.2

ENSEMBL proteins:

ENSP00000237612

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Sigma-Aldrich Proteins for ABCG2
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (BCRP/ABCG2)
	Human Recombinant Proteins from Abnova (ABCG2)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	IEA	--
GO:0016021	integral to membrane	TAS	9850061

About this table

Antibodies for ABCG2:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of ABCG2
	Sigma-Aldrich Antibodies for ABCG2
	R&D Systems Antibodies for ABCG2
	Antibodies from Abcam (BCRP/ABCG2), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (ABCG2)
	Novus Biologicals Antibodies for ABCG2

Assays for ABCG2:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q9UNQ0

ProtoNet protein and cluster: Q9UNQ0

UniProtKB/Swiss-Prot: ABCG2_HUMAN, Q9UNQ0

Similarity: Belongs to the ABC transporter family. ABCG (White) subfamily

Similarity: Contains 1 ABC transmembrane type-2 domain

Similarity: Contains 1 ABC transporter domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ABCG2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ABCG2)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004827

Applied Biosystems Silencer® siRNAs for ABCG2

Sigma-Aldrich siRNA and siRNA Panels for ABCG2

Sigma-Aldrich shRNA for ABCG2

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for ABCG2
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_004827
Myc/DDK tagged cDNA clone in CMV expression vector: NM_004827
untagged cDNA clones in CMV expression vector (see all 2): NM_004827

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_004827

UniProtKB/Swiss-Prot: ABCG2_HUMAN, Q9UNQ0

Function: Xenobiotic transporter that may play an important role in the exclusion of xenobiotics

from the brain. May be involved in brain-to-blood efflux. Appears to play a major role in the

multidrug resistance phenotype of several cancer cell lines. When overexpressed, the transfected

cells become resistant to mitoxantrone, daunorubicin and doxorubicin, display diminished

intracellular accumulation of daunorubicin, and manifest an ATP-dependent increase in the efflux

of rhodamine 123

Induction: Up-regulated in brain tumors

Genatlas biochemistry entry for ABCG2:

ATP binding cassette superfamily,subfamily G (WHITE),member 2,multidrug resistance

transporter,expressed in the placenta,involved in transport of specific molecules into or out the

placenta,homolog to Drosophila white and yeast ADP1 gene

5 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Abcg2):

hematopoietic system

homeostasis/metabolism

liver/biliary system

no phenotypic analysis

skin/coat/nails

5/7 Gene Ontology (GO) molecular function terms (links to tree view) (see all 7 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0005215	transporter activity	TAS	9850061 9861027
GO:0005515	protein binding	IPI	18056989
GO:0005524	ATP binding	TAS	9850061
GO:0008559	xenobiotic-transporting ATPase activity	TAS	9861027

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Gene Network Central^TM Interacting Genes and Proteins Network for ABCG2

5/42 Interacting proteins for ABCG2 (ENSP00000237612³ Q9UNQ0^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 42 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PIM1	P11309-1¹	STRING (score=.901) EBI-1569435, EBI-1018629
ABCG2	Q9UNQ0²	MINT-2840405
EGFR	ENSP00000275493³	STRING (score=.949)
HIF1A	ENSP00000338018³	STRING (score=.909)
ARNT	ENSP00000315637³	STRING (score=.899)

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2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006810	transport	TAS	9850061
GO:0042493	response to drug	TAS	9861027

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Compounds for ABCG2 available from Tocris Bioscience

Compound	Action	CAS number
Ko 143	Potent and selective BCRP inhibitor	[461054-93-3]

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10/47 Novoseek chemical compound relationships for ABCG2 gene (see all 47 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
fumitremorgin c	96.68	86	12477054 (4), 14613996 (4), 10646850 (3), 16490770 (3) (see all 36)
gf 120918	91.55	54	18248513 (3), 10656616 (2), 11309344 (2), 15860656 (2) (see all 24)
pheophorbide a	85.43	14	19131524 (2), 17250810 (2), 17652262 (1), 17518356 (1) (see all 7)
mr20	84.30	4	15788683 (2), 15208643 (1)
(125i)iodoarylazidoprazosin	80.87	17	16846237 (3), 15598974 (1), 18089721 (1), 17575116 (1) (see all 8)
hoechst 33342	79.83	18	19270533 (1), 14612912 (1), 18182157 (1), 15047700 (1) (see all 16)
rhodamine 123	78.69	25	14612912 (2), 15139851 (2), 10806112 (1), 15598974 (1) (see all 15)
gimatecan	74.49	19	17943230 (5), 18089724 (4), 15006540 (2), 11507048 (1)
ortataxel	72.17	4	14617793 (1), 15060738 (1)
oatp	68.33	6	17020956 (1), 18762709 (1), 18838068 (1)

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7 PharmGKB drug compound relationships for ABCG2 gene

Drug compound	PharmGKB Relations	PubMed IDs for articles supporting these relationships
cisplatin	CO	15014021
diflomotecan	PK GN	15229462
folic acid	FA GN	12874005 15047700
irinotecan	FA GN	12810652
leucovorin	FA GN	12874005
methotrexate	PD FA GN	12208758 12874005 15630450
xenobiotics	FA GN	12544509

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ABCG2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ABCG2)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004827

Sigma-Aldrich siRNA and siRNA Panels for ABCG2

Sigma-Aldrich shRNA for ABCG2

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_004827

REFSEQ mRNAs for ABCG2 gene:

NM_004827.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_004827

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_004827
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_004827
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_004827

Additional cDNA sequence:

AB051855.1 AB056867.1 AF093771.1 AF093772.1 AF098951.2 AF103796.1 AF151530.1 AF463519.1

AK002040.1 AK290000.1 AY017168.1 AY288307.1 AY289766.1 AY333755.1 AY333756.1 BC011032.1

BC021281.2 BC092408.1 CR621441.1 U66681.1

9 DOTS entries:

DT.100786807 DT.100786806 DT.453150 DT.100713966 DT.100786805 DT.95109698 DT.102824509 DT.91738759

DT.95197134

24/117 AceView cDNA sequences (see all 117 ):

F08388 R77787 N59214 F04525 BE765504 AB051855 AI141242 BC011032

Z41385 AB056867 CD365766 AW270740 AY017168 AI805085 AI687015 BC021281

BX370114 BX504168 AI424453 BX104985 AF463519 BG573081 BM853954 BE464452

highest scoring ESTs for ABCG2:

AA226753 AA233510 AB051855 AF093771 AF098951 AF103796 AY017168 AY289766 BC011032 BC021281

Unigene Cluster for ABCG2:

ATP-binding cassette, sub-family G (WHITE), member 2

Hs.480218 [show with all ESTs]

Unigene Representative Sequence: NM_004827

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for ABCG2

ExUns:	1a	·	1b	·	1c	·	1d	^	2	^	3a	·	3b	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14a	·	14b	^	15	^	16a	·	16b	·	16c
SP1:
SP2:																																			-
SP3:
SP4:									-
SP5:							-

About this scheme

ECgene alternative splicing isoforms for ABCG2

1 Ensembl transcript including schematic representation:

ENST00000237612

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

ABCG2 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ABCG2

¹ / ² / ³

4 probe-sets matching ABCG2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
33733_at²^{, 3}	U95-A	1	1.00	1.00	0.94	1.23	AF093771	0.80	1.00	0.91	1
59747_at²^{, 3}	U95-C	1	0.62	1.00	0.90	0.78	R42781	0.60	1.00	0.82	1
209735_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AF098951	0.80	1.00	0.91	1
209735_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks ABCG2 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TACTGGCGAA

SOURCE GeneReport for Unigene cluster: Hs.480218
Expression variation in blood from EXPOLDB for ABCG2
UniProtKB/Swiss-Prot: ABCG2_HUMAN, Q9UNQ0
Tissue specificity: Highly expressed in placenta. Low expression in small intestine, liver and
colon

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ABCG2 gene from 5/19 species (see all 19 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ABCG2¹	--	ATP-binding cassette, sub-family G (WHITE), member more	87.01(n) 83.9(a)	478472 XM_535650.2 XP_535650.2
chimpanzee (Pan troglodytes)	ABCG2¹	--	ATP-binding cassette, sub-family G (WHITE), member more	99.39(n) 99.39(a)	471251 XM_526633.2 XP_526633.2
cow (Bos taurus)	ABCG2¹	--	ATP-binding cassette, sub-family G (WHITE), member more	88.12(n) 84.56(a)	536203 NM_001037478.2 NP_001032555.2
rat (Rattus norvegicus)	Abcg2¹	--	ATP-binding cassette, sub-family G (WHITE), member more	82.42(n) 81.5(a)	312382 NM_181381.2 NP_852046.1
mouse (Mus musculus)	Abcg2^{1, 5}	6 (28.50 cM)⁵	ATP-binding cassette, sub-family G (WHITE), member more^{1, 5}	82.47(n)¹ 82.11(a)¹	26357¹ NM_011920.3¹ NP_036050.1¹ AA008579⁵ AF103875⁵ (see all 12)

About this table Species with no ortholog for ABCG2

ENSEMBL Gene Tree for ABCG2

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/522 NCBI SNPs in ABCG2 are shown (see all 522 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 151)

AB	SNP ID	Valid	Chr 4 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
--	rs2231137^1,2	C,F,H,O	89280138(-)	`TCCCAG/ATGTCA`	1	M/V	mis¹ ese³		14	EU EA WA NA NS	2096
--	rs3114019^1,2	A,C,F,H	89300465(+)	`GTTAAT/CGACTG`	1	--	ng3¹		6	EU EA WA NS	512
	rs12721643^1,2	C,F,H	89261884(-)	`CTTCCA/CTCTTG`	1	I/L	mis¹ ese³		6	EU EA WA	1144
	rs1061018^1,2	C,F,H	89261877(-)	`CTTGTT/CCTTGG`	1	S/F	mis¹		14	MN CSAM EA EU WA	1392
	rs2231142^1,2	C,F,H	89271347(-)	`ACTTAC/AAGTTC`	1	K/Q	mis¹		19	EA NA EU WA NS	3932
	rs9282571^1,2	C,F,H	89235722(-)	`AGTACT/ATCAGC`	1	I/F	mis¹ ese³		9	MN CSAM EA EU WA	796
	rs2231135^1,2	F,H	89299018(-)	`TGAGCC/TCGTCC`	1	--	ut5¹ ese³		4	EU EA WA	380
--	rs4148162^1,2	C,F	89299740(-)	`CTCAC-/TCAC AAAGC`	1	--	ng3¹		2	NS	94
--	rs10030206^1,2	C,F	89231115(+)	`gcaacT/Atttct`	1	--	ut3¹		2	NS	92
	rs3201997^1,2	C,H	89253673(-)	`TAGCGG/TAGATT`	1	E/X	non¹ ese³		9	MN EU EA WA	968

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HapMap Linkage Disequilibrium images for ABCG2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 603756

10/53 Novoseek disease relationships for ABCG2 gene (see all 53 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
breast cancer	84.53	520	19035187 (4), 18820913 (4), 11566359 (3), 11948115 (3) (see all 99)
cancer	63.23	155	17767037 (4), 16554028 (4), 16024622 (3), 17456779 (3) (see all 87)
aml adult	58.33	8	12393637 (4), 16278398 (1), 15541485 (1)
tumors	43.76	84	10825126 (3), 16061644 (3), 15146167 (3), 16562373 (2) (see all 61)
nsclc	41.40	53	16520985 (4), 17366786 (4), 12912956 (3), 17534875 (3) (see all 13)
choriocarcinoma	39.91	8	16445700 (2), 11566359 (1), 15634651 (1), 18042733 (1) (see all 6)
aml childhood	36.25	2	18228020 (1), 12145683 (1)
neuroepithelial tumors	34.77	1	14636345 (1)
leukemia	33.56	8	16403267 (1), 10720143 (1), 15521915 (1), 19276246 (1) (see all 6)
solid tumor	31.70	5	14754410 (1), 16146333 (1), 11193894 (1), 17346156 (1)

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3 PharmGKB disease relationships for ABCG2 gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Leukemia, Lymphocytic, Acute, L1	PD FA GN	12730115 15630450
Lung Diseases	CO	15014021
Neoplasms	PK GN	15229462

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Human Gene Mutation Database: ABCG2
Genetic Association Database: ABCG2
Human Genome Epidemiology Navigator: ABCG2 (49 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

Three Genes, Risk Score Can Facilitate Risk Prediction of Gout

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/670 PubMed articles for ABCG2 gene (see all 670 ):

A multidrug resistance transporter from human MCF-7 breast cancer cells. (PubMed id 9861027)^{1, 2, 3, 4} Doyle L.A....Ross D.D. (1998)
Breast cancer resistance protein impacts clinical outcome in platinum-based chemotherapy for advanced non-small cell lung cancer. (PubMed id 15014021)^{1, 3, 7} Yoh K....Ochiai A. (2004)
Diflomotecan pharmacokinetics in relation to ABCG2 421C>A genotype. (PubMed id 15229462)^{3, 6, 7} Sparreboom A....McLeod H.L. (2004)
Differential effects of the breast cancer resistance protein on the cellular accumulation and cytotoxicity of 9-aminocamptothecin and 9-nitrocamptothecin. (PubMed id 12810652)^{1, 3, 7} Rajendra R....Rubin E.H. (2003)
Natural allelic variants of breast cancer resistance protein (BCRP) and their relationship to BCRP expression in human intestine. (PubMed id 12544509)^{1, 4, 7} Zamber C.P.... Schuetz E.G. (2003)
Transport of methotrexate, methotrexate polyglutamates, and 17beta-estradiol 17-(beta-D-glucuronide) by ABCG2: effects of acquired mutations at R482 on methotrexate transport. (PubMed id 12874005)^{1, 3, 7} Chen Z.S....Kruh G.D. (2003)
Overexpression of wild-type breast cancer resistance protein mediates methotrexate resistance. (PubMed id 12208758)^{1, 3, 7} Volk E.L....Schneider E. (2002)
Detection of single nucleotide polymorphisms in the ABCG2 gene in a Dutch population. (PubMed id 15813675)^{1, 3, 6} Bosch T.M....Meijerman I. (2005)
Single nucleotide polymorphisms modify the transporter activity of ABCG2. (PubMed id 15838659)^{1, 3, 4} Morisaki K.... Bates S.E. (2005)
N-linked glycosylation of the human ABC transporter ABCG2 on asparagine 596 is not essential for expression, transport activity, or trafficking to the plasma membrane. (PubMed id 15807535)^{1, 3, 4} Diop N.K. and Hrycyna C.A. (2005)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 9429	HGNC: 74	AceView: ABCG2	Ensembl:ENSG00000118777	euGenes: HUgn9429
ECgene: ABCG2	H-InvDB: ABCG2

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for ABCG2	Genetics and Cytogenetics in Oncology and Haematology
SeattleSNPs	http://pga.gs.washington.edu/data/abcg2/

Licensable Technologies for ABCG2
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for ABCG2:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ABCG2-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ABCG2		Antibodies for ABCG2
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	Lentivirus-delivered shRNAs for ABCG2		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

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	Cell Culture Products		ELISAs
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	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (ABCG2)
	Antibodies (ABCG2)
	Chimera RNAi (ABCG2)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

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	Recombinant Proteins (BCRP/ABCG2)
	Antibodies (BCRP/ABCG2)

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Tocris compounds for ABCG2

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for ABCG2

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ABCG2 Gene

protein-coding GIFtS: 75

Aliases &
Descriptions
for ABCG2

Summaries
for ABCG2

Genomic Location
for ABCG2

Proteins
for ABCG2

Protein Domains/
Families
for ABCG2

Gene Function
for ABCG2

Pathways & Interactions
for ABCG2

Drugs & Compounds
for ABCG2

Transcripts
for ABCG2

Expression
for ABCG2

Orthologs
for ABCG2

Paralogs
for ABCG2

SNPs/Variants
for ABCG2

Disorders & Mutations
for ABCG2

Medical News
for ABCG2

Publications
for ABCG2

Search for ABCG2

Genome Databases showing ABCG2

Other Databases showing ABCG2

Specialized Databases showing ABCG2

Licensable Technologies
for ABCG2

Services
for ABCG2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ABCG2 (Gene Symbol)
ABC15
ABCP
BCRP
BCRP1
BMDP
CD338
CDw338
EST157481
MGC102821
MRX
MXR
MXR1
ABC transporter
ATP-binding cassette transporter G2
ATP-binding cassette, sub-family G (WHITE), member 2
ATP-binding cassette, sub-family G, member 2
Breast cancer resistance protein
CD338 antigen
Mitoxantrone resistance-associated protein
Placenta-specific ATP-binding cassette transporter
mitoxantrone resistance protein
placenta specific MDR protein

ABCG2 Gene

protein-coding GIFtS: 75

Aliases & Descriptionsfor ABCG2

Summariesfor ABCG2

Genomic Locationfor ABCG2

Proteinsfor ABCG2

Protein Domains/Familiesfor ABCG2

Gene Functionfor ABCG2

Pathways & Interactionsfor ABCG2

Drugs & Compoundsfor ABCG2

Transcriptsfor ABCG2

Expression for ABCG2

Orthologsfor ABCG2

Paralogsfor ABCG2

SNPs/Variantsfor ABCG2

Disorders & Mutationsfor ABCG2

Medical Newsfor ABCG2

Publicationsfor ABCG2

Search for ABCG2

Genome Databases showing ABCG2

Other Databases showing ABCG2

Specialized Databases showing ABCG2

Licensable Technologiesfor ABCG2

Servicesfor ABCG2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ABCG2

Summaries
for ABCG2

Genomic Location
for ABCG2

Proteins
for ABCG2

Protein Domains/
Families
for ABCG2

Gene Function
for ABCG2

Pathways & Interactions
for ABCG2

Drugs & Compounds
for ABCG2

Transcripts
for ABCG2

Expression
for ABCG2

Orthologs
for ABCG2

Paralogs
for ABCG2

SNPs/Variants
for ABCG2

Disorders & Mutations
for ABCG2

Medical News
for ABCG2

Publications
for ABCG2

Licensable Technologies
for ABCG2

Services
for ABCG2