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ABCG2 Gene

protein-coding   GIFtS: 75

GC04M089314
ATP-binding cassette, sub-family G (WHITE), member 2
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases
ABC15 2
ABCP 1, 2, 3, 5
BCRP 1, 2, 3, 5
BCRP1 2, 3
BMDP 2
CD338 1, 2
CDw338 2, 3
EST157481 1, 2
MGC102821 2
MRX 2
MXR 1, 2, 3
MXR1 2
Descriptions
ABC transporter 2
ATP-binding cassette transporter G2 2
ATP-binding cassette, sub-family G (WHITE), member 2 2
ATP-binding cassette, sub-family G, member 2 2
Breast cancer resistance protein 2, 3
CD338 antigen 3
Mitoxantrone resistance-associated protein 3
Placenta-specific ATP-binding cassette transporter 3
mitoxantrone resistance protein 2
placenta specific MDR protein 2
External Ids
HGNC: 741
Entrez Gene: 94292
UniProtKB: Q9UNQ03
Ensembl: ENSG000001187777
Search outside databases for aliases for ABCG2 gene

Previous GC identifers: GC04M089170 GC04M089471 GC04M089370

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for ABCG2:
The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding
cassette (ABC) transporters. ABC proteins transport various molecules across extra- and
intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP,
MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. Alternatively
referred to as a breast cancer resistance protein, this protein functions as a xenobiotic
transporter which may play a major role in multi-drug resistance. It likely serves as a cellular
defense mechanism in response to mitoxantrone and anthracycline exposure. Significant expression
of this protein has been observed in the placenta, which may suggest a potential role for this
molecule in placenta tissue. [provided by RefSeq]

UniProtKB/Swiss-Prot: ABCG2_HUMAN, Q9UNQ0
Function: Xenobiotic transporter that may play an important role in the exclusion of xenobiotics
from the brain. May be involved in brain-to-blood efflux. Appears to play a major role in the
multidrug resistance phenotype of several cancer cell lines. When overexpressed, the transfected
cells become resistant to mitoxantrone, daunorubicin and doxorubicin, display diminished
intracellular accumulation of daunorubicin, and manifest an ATP-dependent increase in the efflux
of rhodamine 123

Gene Wiki entry for ABCG2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the ABCG2 gene  

Entrez Gene cytogenetic band: 4q22   Ensembl cytogenetic band:  4q22.1   HGNC cytogenetic band: 4q22-q23

ABCG2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M089314:     (about GC identifiers)

Start:
89,230,440 bp from pter
End:
89,299,035 bp from pter
Size:
68,596 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000004.10  NT_016354.18  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: ABCG2_HUMAN, Q9UNQ0 (See protein sequence)
Recommended Name: ATP-binding cassette sub-family G member 2  
Size: 655 amino acids; 72314 Da
Subunit: Monomer or homodimer; disulfide-linked
Subcellular location: Cell membrane; Multi-pass membrane protein
Sequence caution: Sequence=AF093771; Type=Frameshift; Positions=486, 586; Sequence=AF093772;
Type=Frameshift; Positions=386, 502, 586;
Secondary accessions: A0A1W3 A8K1T5 O95374 Q53ZQ1 Q569L4 Q5YLG4 Q86V64 Q8IX16 Q96LD6 Q96TA8 Q9BY73
Q9NUS0
Alternative splicing: 2 isoforms:  Q9UNQ0-1   Q9UNQ0-2   

Post-translational modifications:

  • Glycosylation-deficient ABCG2 is normally expressed and functional1
  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_004818.2  

    ENSEMBL proteins: 
    ENSP00000237612 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Sigma-Aldrich Proteins for ABCG2  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (BCRP/ABCG2)
    Human Recombinant Proteins from Abnova (ABCG2)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    2 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886 plasma membrane IEA--
    GO:0016021 integral to membrane TAS9850061
    About this table

    Antibodies for ABCG2: 
    Browse Antibodies Central at Invitrogen
    Millipore Mono- and Polyclonal Antibodies for the study of ABCG2
    Sigma-Aldrich Antibodies for ABCG2
    R&D Systems Antibodies for ABCG2
    Antibodies from Abcam (BCRP/ABCG2), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (ABCG2)
    Novus Biologicals Antibodies for ABCG2

    Assays for ABCG2: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    4 InterPro domains/families:
     IPR003439 ABC_transporter-like
     IPR003593 ATPase_AAA+_core
     IPR013525 ABC_2_trans
     IPR017871 ABC_transporter_CS


       GeneDecks  ABCG2 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q9UNQ0

    ProtoNet protein and cluster: Q9UNQ0

    UniProtKB/Swiss-Prot: ABCG2_HUMAN, Q9UNQ0
    Similarity: Belongs to the ABC transporter family. ABCG (White) subfamily
    Similarity: Contains 1 ABC transmembrane type-2 domain
    Similarity: Contains 1 ABC transporter domain

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (ABCG2)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (ABCG2)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004827

                  Applied Biosystems Silencer® siRNAs for ABCG2

                  Sigma-Aldrich siRNA and siRNA Panels for ABCG2  
                         Sigma-Aldrich shRNA for ABCG2  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for ABCG2
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_004827
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_004827
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_004827 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_004827

    UniProtKB/Swiss-Prot: ABCG2_HUMAN, Q9UNQ0
    Function: Xenobiotic transporter that may play an important role in the exclusion of xenobiotics
    from the brain. May be involved in brain-to-blood efflux. Appears to play a major role in the
    multidrug resistance phenotype of several cancer cell lines. When overexpressed, the transfected
    cells become resistant to mitoxantrone, daunorubicin and doxorubicin, display diminished
    intracellular accumulation of daunorubicin, and manifest an ATP-dependent increase in the efflux
    of rhodamine 123
    Induction: Up-regulated in brain tumors

    Genatlas biochemistry entry for ABCG2:
    ATP binding cassette superfamily,subfamily G (WHITE),member 2,multidrug resistance
    transporter,expressed in the placenta,involved in transport of specific molecules into or out the
    placenta,homolog to Drosophila white and yeast ADP1 gene

    5 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Abcg2):

    hematopoietic systemhomeostasis/metabolismliver/biliary systemno phenotypic analysisskin/coat/nails

    5/7 Gene Ontology (GO) molecular function terms (links to tree view) (see all 7 ):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166 nucleotide binding IEA--
    GO:0005215 transporter activity TAS9850061 9861027
    GO:0005515 protein binding IPI18056989
    GO:0005524 ATP binding TAS9850061
    GO:0008559 xenobiotic-transporting ATPase activity TAS9861027
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


    1 Millipore Pathway for ABCG2
     Selected targets of ESR1

       GeneDecks  ABCG2 for the pathways selected above  
    About GeneDecksing

    1 Kegg Pathway  (Kegg details for ABCG2):
     hsa02010 ABC transporters

       GeneDecks  ABCG2 for the pathways selected above  
    About GeneDecksing
     Gene Network CentralTM Interacting Genes and Proteins Network for  ABCG2 


    5/42 Interacting proteins for ABCG2 (ENSP000002376123 Q9UNQ01, 2) via UniProtKB, MINT, and/or STRING (see all 42 )
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PIM1P11309-11STRING (score=.901) EBI-1569435, EBI-1018629
    ABCG2Q9UNQ02MINT-2840405
    EGFRENSP000002754933STRING (score=.949)
    HIF1AENSP000003380183STRING (score=.909)
    ARNTENSP000003156373STRING (score=.899)
    About this table

    2 Gene Ontology (GO) biological process terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810 transport TAS9850061
    GO:0042493 response to drug TAS9861027
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Compounds for ABCG2 available from Tocris Bioscience
    CompoundAction CAS number
    Ko 143Potent and selective BCRP inhibitor[461054-93-3]
    About this table


    10/47 Novoseek chemical compound relationships for ABCG2 gene (see all 47 )
    Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    fumitremorgin c 96.68 86 12477054 (4), 14613996 (4), 10646850 (3), 16490770 (3) (see all 36)
    gf 120918 91.55 54 18248513 (3), 10656616 (2), 11309344 (2), 15860656 (2) (see all 24)
    pheophorbide a 85.43 14 19131524 (2), 17250810 (2), 17652262 (1), 17518356 (1) (see all 7)
    mr20 84.30 4 15788683 (2), 15208643 (1)
    (125i)iodoarylazidoprazosin 80.87 17 16846237 (3), 15598974 (1), 18089721 (1), 17575116 (1) (see all 8)
    hoechst 33342 79.83 18 19270533 (1), 14612912 (1), 18182157 (1), 15047700 (1) (see all 16)
    rhodamine 123 78.69 25 14612912 (2), 15139851 (2), 10806112 (1), 15598974 (1) (see all 15)
    gimatecan 74.49 19 17943230 (5), 18089724 (4), 15006540 (2), 11507048 (1)
    ortataxel 72.17 4 14617793 (1), 15060738 (1)
    oatp 68.33 6 17020956 (1), 18762709 (1), 18838068 (1)
    About this table

    7 PharmGKB drug compound relationships for ABCG2 gene
    Drug compound PharmGKB Relations PubMed IDs for articles supporting these relationships
    cisplatinCO  15014021
    diflomotecanPK  GN  15229462
    folic acidFA  GN  12874005 15047700
    irinotecanFA  GN  12810652
    leucovorinFA  GN  12874005
    methotrexatePD  FA  GN  12208758 12874005 15630450
    xenobioticsFA  GN  12544509
    About this table


    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (ABCG2)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (ABCG2)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004827

                  Sigma-Aldrich siRNA and siRNA Panels for ABCG2  
                         Sigma-Aldrich shRNA for ABCG2  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_004827  

    REFSEQ mRNAs for ABCG2 gene: 

    NM_004827.2   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_004827  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_004827
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_004827
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_004827 

    Additional cDNA sequence: 

    AB051855.1 AB056867.1 AF093771.1 AF093772.1 AF098951.2 AF103796.1 AF151530.1 AF463519.1 
    AK002040.1 AK290000.1 AY017168.1 AY288307.1 AY289766.1 AY333755.1 AY333756.1 BC011032.1 
    BC021281.2 BC092408.1 CR621441.1 U66681.1 

    9 DOTS entries:

    DT.100786807  DT.100786806  DT.453150  DT.100713966  DT.100786805  DT.95109698  DT.102824509  DT.91738759 
    DT.95197134 

    24/117 AceView cDNA sequences (see all 117 ):

    F08388 R77787 N59214 F04525 BE765504 AB051855 AI141242 BC011032 
    Z41385 AB056867 CD365766 AW270740 AY017168 AI805085 AI687015 BC021281 
    BX370114 BX504168 AI424453 BX104985 AF463519 BG573081 BM853954 BE464452 

    highest scoring ESTs for ABCG2:

    AA226753 AA233510 AB051855 AF093771 AF098951 AF103796 AY017168 AY289766 BC011032 BC021281 

    Unigene Cluster for ABCG2:

    ATP-binding cassette, sub-family G (WHITE), member 2
    Hs.480218  [show with all ESTs]
    Unigene Representative Sequence: NM_004827


    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for ABCG2

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b · 16c
    SP1:                                                                                                                                          
    SP2:                                                                                                        -                                 
    SP3:                                                                                                                                          
    SP4:                          -                                                                                                               
    SP5:                    -                                                                                                                     

    About this scheme

    ECgene alternative splicing isoforms for ABCG2

    1 Ensembl transcript including schematic representation:
    ENST00000237612  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    ABCG2 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for ABCG2

    1 / 2 / 3

    4 probe-sets matching ABCG2 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    33733_at2, 3 U95-A 1 1.00 1.00 0.94 1.23 AF093771 0.80 1.00 0.91 1

    59747_at2, 3 U95-C 1 0.62 1.00 0.90 0.78 R42781 0.60 1.00 0.82 1

    209735_at2, 3 U133-A 1 1.00 1.00 -- -- AF098951 0.80 1.00 0.91 1

    209735_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    GeneDecks  ABCG2 for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: TACTGGCGAA

    SOURCE GeneReport for Unigene cluster: Hs.480218

    Expression variation in blood from EXPOLDB for ABCG2

    UniProtKB/Swiss-Prot: ABCG2_HUMAN, Q9UNQ0
    Tissue specificity: Highly expressed in placenta. Low expression in small intestine, liver and
    colon

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for ABCG2 gene from 5/19 species (see all 19 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    ABCG21   -- ATP-binding cassette, sub-family G (WHITE), member more 87.01(n)
    83.9(a)
    478472  XM_535650.2  XP_535650.2 
    chimpanzee
    (Pan troglodytes)
    ABCG21   -- ATP-binding cassette, sub-family G (WHITE), member more 99.39(n)
    99.39(a)
    471251  XM_526633.2  XP_526633.2 
    cow
    (Bos taurus)
    ABCG21   -- ATP-binding cassette, sub-family G (WHITE), member more 88.12(n)
    84.56(a)
    536203  NM_001037478.2  NP_001032555.2 
    rat
    (Rattus norvegicus)
    Abcg21   -- ATP-binding cassette, sub-family G (WHITE), member more 82.42(n)
    81.5(a)
    312382  NM_181381.2  NP_852046.1 
    mouse
    (Mus musculus)
    Abcg21, 5 6 (28.50 cM)5
    ATP-binding cassette, sub-family G (WHITE), member more1, 5 82.47(n)1
    82.11(a)1
    263571  NM_011920.31  NP_036050.11 
     AA0085795  AF1038755  (see all 12)
    About this table        Species with no ortholog for ABCG2

    ENSEMBL Gene Tree for ABCG2
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

      --
    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/522 NCBI SNPs in ABCG2 are shown (see all 522 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 151)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 4 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    --
    rs22311371,2
    C,F,H,O89280138(-) TCCCAG/ATGTCA 1 M/V mis1 ese314Minor allele frequency- A:0.21EU EA WA NA NS 2096
    --
    rs31140191,2
    A,C,F,H89300465(+) GTTAAT/CGACTG 1 -- ng316Minor allele frequency- C:0.15EU EA WA NS 512
    rs127216431,2
    C,F,H89261884(-) CTTCCA/CTCTTG 1 I/L mis1 ese36Minor allele frequency- C:0.00EU EA WA 1144
    rs10610181,2
    C,F,H89261877(-) CTTGTT/CCTTGG 1 S/F mis114Minor allele frequency- C:0.00MN CSAM EA EU WA 1392
    rs22311421,2
    C,F,H89271347(-) ACTTAC/AAGTTC 1 K/Q mis119Minor allele frequency- A:0.20EA NA EU WA NS 3932
    rs92825711,2
    C,F,H89235722(-) AGTACT/ATCAGC 1 I/F mis1 ese39Minor allele frequency- A:0.00MN CSAM EA EU WA 796
    rs22311351,2
    F,H89299018(-) TGAGCC/TCGTCC 1 -- ut51 ese34Minor allele frequency- T:0.01EU EA WA 380
    --
    rs41481621,2
    C,F89299740(-) CTCAC-/TCAC  
            
    AAAGC
    1 -- ng312Minor allele frequency- TCAC:0.27NS 94
    --
    rs100302061,2
    C,F89231115(+) gcaacT/Atttct 1 -- ut312Minor allele frequency- A:0.04NS 92
    rs32019971,2
    C,H89253673(-) TAGCGG/TAGATT 1 E/X non1 ese39Minor allele frequency- T:0.00MN EU EA WA 968
    About this table

    HapMap Linkage Disequilibrium images for ABCG2 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 603756

    10/53 Novoseek disease relationships for ABCG2 gene (see all 53 )

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    breast cancer 84.53 520 19035187 (4), 18820913 (4), 11566359 (3), 11948115 (3) (see all 99)
    cancer 63.23 155 17767037 (4), 16554028 (4), 16024622 (3), 17456779 (3) (see all 87)
    aml adult 58.33 8 12393637 (4), 16278398 (1), 15541485 (1)
    tumors 43.76 84 10825126 (3), 16061644 (3), 15146167 (3), 16562373 (2) (see all 61)
    nsclc 41.40 53 16520985 (4), 17366786 (4), 12912956 (3), 17534875 (3) (see all 13)
    choriocarcinoma 39.91 8 16445700 (2), 11566359 (1), 15634651 (1), 18042733 (1) (see all 6)
    aml childhood 36.25 2 18228020 (1), 12145683 (1)
    neuroepithelial tumors 34.77 1 14636345 (1)
    leukemia 33.56 8 16403267 (1), 10720143 (1), 15521915 (1), 19276246 (1) (see all 6)
    solid tumor 31.70 5 14754410 (1), 16146333 (1), 11193894 (1), 17346156 (1)
    About this table

    3 PharmGKB disease relationships for ABCG2 gene
    Disease PharmGKB Relations PubMed IDs for articles supporting these relationships
    Leukemia, Lymphocytic, Acute, L1PD  FA  GN  12730115 15630450
    Lung DiseasesCO  15014021
    NeoplasmsPK  GN  15229462
    About this table

    Human Gene Mutation Database: ABCG2
    Genetic Association Database: ABCG2
    Human Genome Epidemiology Navigator: ABCG2 (49 documents)

    (Possibly Related Articles in Doctor's Guide)
    About This Section

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
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    10/670 PubMed articles for ABCG2 gene (see all 670 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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    Entrez Gene: 9429 HGNC: 74 AceView: ABCG2 Ensembl:ENSG00000118777 euGenes: HUgn9429
    ECgene: ABCG2 H-InvDB: ABCG2
    (According to HUGE)
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      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

    NameDescription
    ATLAS Chromosomes in Cancer entry for ABCG2 Genetics and Cytogenetics in Oncology and Haematology
    SeattleSNPshttp://pga.gs.washington.edu/data/abcg2/
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



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