ABCG1 Gene
protein-coding GIFtS : 64
GCID: GC21 P043619
ATP-binding cassette, sub-family G (WHITE), member 1
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Aliasesfor ABCG1 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
10 fRNAdb , and/or 11 Nature :405,311-319 and CroW21)About This Section Aliases ATP-Binding Cassette, Sub-Family G (WHITE), Member 1 1 2 ATP-Binding Cassette Sub-Family G Member 12 ABC81 2 3 5 ATP-Binding Cassette Transporter Member 1 Of Subfamily G2 White Protein Homolog (ATP-Binding Cassette Transporter 8)2 11 Homolog Of Drosophila White2 ATP-Binding Cassette Transporter 82 3 WHT13 WHITE12 5 White Protein Homolog3 ABC Transporter 82
Export aliases for ABCG1 gene to outside databases Previous GC identifers: GC21P040187 GC21P042514 GC21P042533 GC21P042496 GC21P042492 GC21P029038
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Summariesfor ABCG1 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for ABCG1 : The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. It is involved in macrophage cholesterol and phospholipids transport, and may regulate cellular lipid homeostasis in other cell types. Six alternative splice variants have been identified. (provided by RefSeq, Jul 2008) UniProtKB/Swiss-Prot: ABCG1_HUMAN, P45844 Function : Transporter involved in macrophage lipid homeostasis. Is an active component of the macrophage lipid exportcomplex. Could also be involved in intracellular lipid transport processes. The role in cellular lipid homeostasis may not be limited to macrophages Gene Wiki entry for ABCG1
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Genomic Viewsfor ABCG1 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics , Whole Chromsome Sequence According to
Nature (Cited Here with Permission) :405,311-319 and CroW21)About This Section
GC21P043619:
GeneLoc
Nature :405,311-319
Start:
43,619,799 bp from pter
29,186,705 bp from centromere
End:
43,720,714 bp from pter
29,264,680 bp from centromere
Size:
100,916 bases
77,976 bases
Orientation:
plus strand
plus strand
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Proteinsfor ABCG1 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: ABCG1_HUMAN, P45844 (See
protein sequence )Recommended Name: ATP-binding cassette sub-family G member 1 Size : 678 amino acids; 75592 Da
Subunit : May form heterodimers with several heterologous partners of the ABCG subfamily
Subcellular location : Mitochondrion. Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatusmembrane; Multi-pass membrane protein. Note=Predominantly localized in the intracellular compartments mainly associated with the endoplasmic reticulum (ER) and Golgi membranes
Miscellaneous : A protein of the expected size has been detected by antibody binding and Western blot in at least one ofthe analyzed tissues or cells (PubMed:22042635)
Sequence caution : Sequence=AAC51098.1; Type=Erroneous initiation; Note=Translation N-terminally extended;Sequence=AAK28841.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAA95530.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAB13728.2; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=CAA62631.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=CAC00730.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions : Q86SU8 Q96L76 Q9BXK6 Q9BXK7 Q9BXK8 Q9BXK9 Q9BXL0 Q9BXL1 Q9BXL2 Q9BXL3 Q9BXL4Alternative splicing : 8 isoforms : P45844-1 P45844-2 P45844-3 P45844-4 P45844-5 P45844-6 P45844-7 P45844-8 Explore the universe of human proteins at neXtProt for ABCG1: NX_P45844 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_P45844 ABCG1 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins (6 alternative transcripts):
NP_004906.3 NP_058198.2 NP_997057.1 NP_997510.1 NP_997511.1 NP_997512.1 ENSEMBL proteins: ENSP00000381475 ENSP00000291524 ENSP00000414541 ENSP00000381467 ENSP00000354995 ENSP00000339744 ENSP00000381464 ENSP00000420100 ENSP00000417667 ENSP00000420245 ENSP00000343820 Reactome Protein details: P45844 Human Recombinant Protein Products: Gene Ontology (GO): 5/11 cellular component terms (GO ID links to tree view) (see all 11 ): About this table
ABCG1 for ontologies About GeneDecksing ABCG1 Antibody Products: Assay Products for ABCG1:
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Protein
Domains / Familiesfor ABCG1 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
ABCG1 for domains About GeneDecksing 5/6 InterPro domains/families (see all 6 ):
Graphical View of Domain Structure for InterPro Entry P45844 ProtoNet protein and cluster: P45844
UniProtKB/Swiss-Prot: ABCG1_HUMAN, P45844 Similarity : Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204)subfamily Similarity : Contains 1 ABC transmembrane type-2 domainSimilarity : Contains 1 ABC transporter domain
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Functionfor ABCG1 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: ABCG1_HUMAN, P45844 Function : Transporter involved in macrophage lipid homeostasis. Is an active component of the macrophage lipid exportcomplex. Could also be involved in intracellular lipid transport processes. The role in cellular lipid homeostasis may not be limited to macrophages Induction : Strongly induced in monocyte-derived macrophages during cholesterol influx. Conversely, mRNA and proteinexpression are suppressed by lipid efflux. Induction is mediated by the liver X receptor/retinoid X receptor (LXR/RXR) pathway. Not induced by bacterial lipopolysaccharides (LPS). Repressed by ZNF202
Genatlas biochemistry entry for ABCG1 : ATP-binding cassette superfamily,subfamily G (WHITE),member 1,homolog of Drosophila White (W),expresed in cholesterol-laden macrophages,localized at the cell surface or in intracellular compartments,regulated by cholesterol uptake or HDL-mediated lipid release,potentially involved in macrophage lipid homeostasis Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for ABCG1 (see all 8 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for ABCG1 (see all 6 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 6 ): ABCG1 (NM_004915 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ABCG1 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat ABCG1
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ABCG1
Gene Ontology (GO): 5/13 molecular function terms (GO ID links to tree view) (see all 13 ): About this table
ABCG1 for ontologies About GeneDecksing Animal Models: Mouse knock-out Abcg1 tm1Asch for ABCG1 12 MGI mutant phenotypes (inferred from 4 alleles ) (MGI details for Abcg1) :
ABCG1 for phenotypes About GeneDecksing
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Pathways & Interactionsfor ABCG1 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways  - 5/6 super-pathways (see all 6 ) About this table See pathways by source Super-pathway contained gene-specific pathways 1 Lipoprotein metabolism 2 ABC-family proteins mediated transport 3 Metabolism 4 Cholesterol and Sphingolipids transport / Recycling to plasma membrane in lung (normal and CF) 5 Nuclear receptors in lipid metabolism and toxicity
Pathway sources See GeneCards unified pathways Show all pathways 1 GeneGo (Thomson Reuters) Pathway for ABCG1 1 BioSystems Pathway for ABCG1 5/8
Reactome Pathways for ABCG1 (see all 8 )1
Kegg Pathway (Kegg details for ABCG1) :
ABCG1 for pathways About GeneDecksing Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ABCG1 STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)3 Interacting proteins for ABCG1 (ENSP00000354995 4 ) via UniProtKB, MINT, STRING , and/or I2D About this table Gene Ontology (GO): 5/29 biological process terms (GO ID links to tree view) (see all 29 ): About this table
ABCG1 for ontologies About GeneDecksing
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Drugs & Compoundsfor ABCG1 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section
ABCG1 for compounds About GeneDecksing Browse Tocris compounds for ABCG1 1 DrugBank Compound for ABCG1 About this table 10/18 Novoseek chemical compound relationships for ABCG1 gene (see all 18 ) About this table
Compound
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
24(s),25-epoxycholesterol
85.6
1
17186944 (1)
cholesterol
80.2
242
15994327 (8), 15210959 (6), 16702602 (5), 10639163 (5) (see all 99 )
22r-hydroxycholesterol
78.8
3
10799558 (1), 17478758 (1), 15777536 (1)
27-hydroxycholesterol
77.2
4
17088262 (3)
22-hydroxycholesterol
74.6
1
16498511 (1)
sterol
74.5
16
19895785 (2), 10799558 (1), 14993242 (1), 16498511 (1) (see all 12 )
essentiale
57.7
2
16702602 (1), 10639163 (1)
lipid
56.7
29
15994327 (3), 16798073 (2), 16680026 (2), 19146988 (2) (see all 18 )
atp
47.3
30
11279031 (2), 15994327 (2), 16702602 (1), 17408620 (1) (see all 21 )
3-hydroxy-3-methylglutaryl-coa
41.2
2
16647568 (1)
Search CenterWatch for drugs/clinical trials and news about ABCG1
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Transcriptsfor ABCG1 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for ABCG1 gene (7 alternative transcripts): NM_004915.3 NM_016818.2 NM_207174.1 NM_207627.1 NM_207628.1 NM_207629.1 NM_207630.1 Unigene Cluster for ABCG1:
ATP-binding cassette, sub-family G (WHITE), member 1 Hs.124649 [show with all ESTs ] Unigene Representative Sequence: AY048757 15 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000398457 (uc002zam.3 uc002zan.3 ) ENST00000462050 ENST00000347800 (uc002zao.3 )ENST00000450121 ENST00000398449 (uc002zap.3 ) ENST00000361802 (uc002zaq.3 )ENST00000343687 (uc002zar.3 uc011aev.2 ) ENST00000398437 ENST00000472587 ENST00000467818 ENST00000489035 ENST00000469119 ENST00000482161 ENST00000496783 (uc010gpb.2 )ENST00000340588 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for ABCG1 (see all 8 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for ABCG1 (see all 6 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 6 ): ABCG1 (NM_004915 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ABCG1 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat ABCG1
Additional cDNA sequence: AF038175.1 AF323660.1 AF323661.1 AF323662.1 AF323663.1 AF323664.1 AK292152.1 AK298491.1 AL355688.1 AL355711.1 AY048757.1 BC029158.1 X91249.1 Z38010.1
15 DOTS entries : DT.97841101 DT.422183
DT.99993759 DT.100025709 DT.443043 DT.102825859 DT.97841102 DT.97841100 DT.95270333 DT.100025708 DT.92422733 DT.95199656 DT.121133864 DT.315220 DT.40107841 24/117 AceView cDNA sequences (see all 117 ):
AA297906 AW262124 AI300841 BE466692 BF527440 NM_004915 AU119946 BI258309 F08291 AA748203 CD672447 NM_016818 F04520 NM_207627 Z39977 AW083232 NM_207628 AI810215 CD674019 BC029158 AI678557 AU121706 AA297995 NM_207630 GeneLoc Exon Structure 5/6 Alternative Splicing Database (ASD) splice patterns (SP) for ABCG1 (see all 6 ) About this scheme ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 SP1 :                       -                       SP2 :                                             SP3 :                                             SP4 :                                             SP5 :                                            
ECgene alternative splicing isoforms for ABCG1
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Expression for ABCG1 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section ABCG1 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: CAGACATTTT
About this image ABCG1 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table See ABCG1 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for ABCG1 SOURCE GeneReport for Unigene cluster: Hs.124649 UniProtKB/Swiss-Prot: ABCG1_HUMAN, P45844 Tissue specificity : Expressed in several tissues. Expressed in macrophages; expression is increased in macrophages frompatients with Tangier disease SABiosciences Expression via Pathway-Focused PCR Arrays including ABCG1 : Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for ABCG1Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat ABCG1 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat ABCG1 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat ABCG1 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ABCG1
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Orthologsfor ABCG1 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of eukaryotes.
Orthologs for ABCG1 gene from 7/28 species (see all 28 ) About this table
Organism
Taxonomic classification
Gene
Description
Human Similarity
Orthology Type
Details
chicken (Gallus gallus)
Aves
ABCG11
ATP-binding cassette, sub-family G (WHITE), member more
78.75(n) 91.57(a)
 
418533 XM_003640501.1 XP_003640549.1
lizard (Anolis carolinensis)
Reptilia
ABCG16
--
90(a)
1 ↔ 1
3(137828481-137880261)
zebrafish (Danio rerio)
Actinopterygii
abcg11
ATP-binding cassette, sub-family G (WHITE), member more
75.98(n) 86.19(a)
 
556979 NM_001110454.1 NP_001103924.1
fruit fly (Drosophila melanogaster)
Insecta
Atet1 , 3
ATP-binding cassette (ABC) transporter3 ABC transporter expressed in trachea1
63(a) (best of 10)3 61.34(n) 1 56.06(a) 1
 
33636 1 NM_001103608.2 1 NP_001097078.1 1
worm (Caenorhabditis elegans)
Secernentea
F02E11.13 wht-51
ABC transpoter3 Protein WHT-51
30(a) (best of 7)3 43.05(n) 1 33.11(a) 1
 
II(3279207-3281668)3 178182 1 NM_069951.3 1 NP_502352.1 1
thale cress (Arabidopsis thaliana)
eudicotyledons
WBC271
ABC-2 type transporter family protein
43.44(n) 32.09(a)
 
820512 NM_112162.2 NP_187928.2
rice (Oryza sativa)
Liliopsida
Os06g06077001
hypothetical protein
47.92(n) 32.38(a)
 
4341486 NM_001064568.1 NP_001058033.1
ENSEMBL Gene Tree for ABCG1 (if available)TreeFam Gene Tree for ABCG1 (if available)
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Paralogsfor ABCG1 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for ABCG1 gene ABCA1 2 ABCA10 2 ABCA13 2 ABCA3 2 ABCA8 2 ABCG4 2 ABCA12 2 ABCG8 2 ABCA4 2 ABCA7 2 ABCG5 2 ABCA2 2 ABCA9 2 ABCA6 2 ABCA5 2 ABCG2 2 6 SIMAP similar genes for ABCG1 using alignment to 4 protein entries: ABCG1_HUMAN (see all proteins ):white ABCG4 DKFZp434P1420 ABCB4 ABCG2 ABCG5
ABCG1 for paralogs About GeneDecksing
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Genomic Variantsfor ABCG1 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 21 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for ABCG1 (43619799 - 43720714 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 4 variations for ABCG1 1 CNV : 103103 3 Indels : 46178 26973 46179 Human Gene Mutation Database (HGMD) : ABCG1 SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing ABCG1
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Disorders
/ Diseasesfor ABCG1 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database , Novoseek ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
ABCG1 for disorders About GeneDecksing
OMIM gene information: 603076
OMIM disorders : --20/31 diseases for ABCG1 (see all 31 ): About MalaCards autosomal recessive nonsyndromic deafness blue color blindness nonsyndromic deafness pulmonary alveolar proteinosis cholesterol type 2 diabetes mellitus cetp deficiency bipolar affective disorder tangier disease color blindness sitosterolemia diabetes mellitus squamous cell carcinoma neurologic diseases hyperlipidemia hypercholesterolemia atherosclerosis alzheimer's disease ovarian cancer blindness 1 disease from the University of Copenhagen DISEASES database for ABCG1 :Atherosclerosis 6 Novoseek disease relationships for ABCG1 gene About this table
Genetic Association Database (GAD): ABCG1 Human Genome Epidemiology (HuGE) Navigator: ABCG1 (15 documents) Export disorders for ABCG1 gene to outside databases
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Publicationsfor ABCG1 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for ABCG1 gene, integrated from 9 sources (see all 220 ): (articles sorted by number of sources associating them with ABCG1) Utopia : connect your pdf to the dynamic world of online information
Cloning of the cDNA for a human homologue of the Drosophila white gene and mapping to chromosome 21q22.3. (PubMed id 8659545) 1 , 2 , 3 Chen H.M.... Antonarakis S.E. (1996) ABCG1 (ABC8), the human homolog of the Drosophila white gene, is a regulator of macrophage cholesterol and phospholipid transport. (PubMed id 10639163) 1 , 2 , 9 Klucken J.... Schmitz G. (2000) Expression and functional characterization of ABCG1 splice variant ABCG1(666). (PubMed id 16870176) 1 , 3, 9 Engel T....Seedorf U. (2006) Expression of the ATP-binding cassette transporter gene ABCG1 (ABC8) in Tangier disease. (PubMed id 11350058) 1 , 2 , 9 Lorkowski S.... Cullen P. (2001) The zinc finger protein 202 (ZNF202) is a transcriptional repressor of ATP binding cassette transporter A1 (ABCA1) and ABCG1 gene expression and a modulator of cellular lipid efflux. (PubMed id 11279031) 1 , 2 , 9 Porsch-Oezcueruemez M.... Schmitz G. (2001) Human white/murine ABC8 mRNA levels are highly induced in lipid- loaded macrophages. A transcriptional role for specific oxysterols. (PubMed id 10799558) 1 , 2 , 9 Venkateswaran A.... Edwards P.A. (2000) Role of ABCG1 and other ABCG family members in lipid metabolism. (PubMed id 11590207) 1 , 2 , 9 Schmitz G.... Heimerl S. (2001) Genomic sequence and structure of the human ABCG1 (ABC8) gene. (PubMed id 11162488) 1 , 2 , 9 Lorkowski S.... Cullen P. (2001) Characterization of the human ABCG1 gene: liver X receptor activates an internal promoter that produces a novel transcript encoding an alternative form of the protein. (PubMed id 11500512) 1 , 2 , 9 Kennedy M.A.... Edwards P.A. (2001) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004)
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External Searches for ABCG1 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing ABCG1 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
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Other Databases showing ABCG1 gene
(According to HUGE )
About This Section --
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Specialized Databases showing ABCG1 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for ABCG1 Pharmacogenomics, SNPs, Pathways ABCMdb http://abcmutations.hegelab.org/proteinDetails?uniprot_id=P45844
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About This Section Patent Information for ABCG1 gene: Search GeneIP for patents involving ABCG1 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor ABCG1 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
OriGene Antibodies for ABCG1 OriGene shRNA RFP for ABCG1 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for ABCG1 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for ABCG1 Browse OriGene Protein Over-expression Lysates Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for ABCG1 OriGene 3'-UTR Clone for ABCG1 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for ABCG1 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for ABCG1 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs OriGene Purified Protein for ABCG1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for ABCG1 OriGene Custom Protein Services for ABCG1 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ABCG1 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing ABCG1 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ABCG1 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat ABCG1 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat ABCG1 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat ABCG1
Search Tocris compounds for ABCG1
ABCG1 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ABCG1
ThermoFisher Antibodies for ABCG1
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat ABCG1
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