V3 here soon-try beta now


Gene Search (GeneCards Home)	\|	GeneCards Guide	\|	User Feedback	\|	Terms of Use	\|	Notice about third-party sites

ABCG1 Gene

protein-coding GIFtS: 62

GC21P042492

ATP-binding cassette, sub-family G (WHITE), member 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase, and/or ⁹Nature:405,311-319 and CroW21)
About This Section

Aliases
ABC8 ^¹, ², ³, ⁵
MGC34313 ^²
OTTHUMP00000109322 ^²
WHITE1 ^², ⁵
WHT1 ^³

Descriptions
ABC transporter 8 ^²
ATP-binding cassette sub-family G member 1 ^²
ATP-binding cassette transporter 8 ^², ³
ATP-binding cassette transporter member 1 of subfamily G ^²
ATP-binding cassette, sub-family G (WHITE), member 1 ^²
ATP-binding cassette, sub-family G, member 1 ^¹
White protein homolog ^³
homolog of Drosophila white ^²
white protein homolog (ATP-binding cassette transporter 8) ^², 9

External Ids
HGNC: 73¹
Entrez Gene: 9619²
UniProtKB: P45844³
Ensembl: ENSG00000160179⁷

Search outside databases for aliases for ABCG1 gene

Previous GC identifers: GC21P040187 GC21P042514 GC21P042533 GC21P042496

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for ABCG1:

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC)

transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes.

ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20,

White). This protein is a member of the White subfamily. It is involved in macrophage cholesterol

and phospholipids transport, and may regulate cellular lipid homeostasis in other cell types. Six

alternative splice variants have been identified. [provided by RefSeq]

UniProtKB/Swiss-Prot: ABCG1_HUMAN, P45844

Function: Transporter involved in macrophage lipid homeostasis. Is an active component of the

macrophage lipid export complex. Could also be involved in intracellular lipid transport

processes. The role in cellular lipid homeostasis may not be limited to macrophages

Gene Wiki entry for ABCG1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences, Whole Chromsome Sequence According to Nature (Cited Here with Permission):405,311-319 and CroW21)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q22.3 Ensembl cytogenetic band: 21q22.3 HGNC cytogenetic band: 21q22.3
Nature(405: 311-319) cytogenetic band: 21q22.3

ABCG1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 21 GeneLoc Exon Structure

(about GC identifiers)

GC21P042492:	GeneLoc	Nature:405,311-319
Start:	42,492,868 bp from pter	29,186,705 bp from centromere
End:	42,590,423 bp from pter	29,264,680 bp from centromere
Size:	97,556 bases	77,976 bases
Orientation:	plus strand	plus strand

RefSeq DNA sequence:

NC_000021.7 NT_030188.4

Whole chromosome sequencing:
cDNA sequence:	X91249
genomic clones:	KB1430A10 KB169B4

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: ABCG1_HUMAN, P45844 (See protein sequence)

Recommended Name: ATP-binding cassette sub-family G member 1

Size: 678 amino acids; 75592 Da

Subunit: May form heterodimers with several heterologous partners of the ABCG subfamily

Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus

membrane; Multi-pass membrane protein. Note=Predominantly localized in the intracellular

compartments mainly associated with the endoplasmic reticulum (ER) and Golgi membranes

Secondary accessions: Q86SU8 Q96L76 Q9BXK6 Q9BXK7 Q9BXK8 Q9BXK9 Q9BXL0 Q9BXL1 Q9BXL2 Q9BXL3 Q9BXL4

Alternative splicing: 8 isoforms: P45844-1 P45844-2 P45844-3 P45844-4 P45844-5 P45844-6 P45844-7 P45844-8

(Additional isoforms seem to exist)

REFSEQ proteins (6 alternative transcripts):

NP_004906.3 NP_058198.2 NP_997057.1 NP_997510.1 NP_997511.1 NP_997512.1

ENSEMBL proteins:

ENSP00000343820 ENSP00000339744 ENSP00000381467 ENSP00000381464 ENSP00000354995 ENSP00000291524

ENSP00000381475

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (ABCG1)
	Human Recombinant Proteins from Abnova (ABCG1)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5/7 Gene Ontology (GO) cellular component terms (links to tree view) (see all 7 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000139	Golgi membrane	IEA	--
GO:0005768	endosome	ISS	--
GO:0005783	endoplasmic reticulum	IEA	--
GO:0005789	endoplasmic reticulum membrane	IEA	--
GO:0005794	Golgi apparatus	IDA	16780588

About this table

Antibodies for ABCG1:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for ABCG1
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (ABCG1), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (ABCG1)
	Novus Biologicals Antibodies for ABCG1

Assays for ABCG1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P45844

ProtoNet protein and cluster: P45844

UniProtKB/Swiss-Prot: ABCG1_HUMAN, P45844

Similarity: Belongs to the ABC transporter family. ABCG (White) subfamily

Similarity: Contains 1 ABC transmembrane type-2 domain

Similarity: Contains 1 ABC transporter domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ABCG1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ABCG1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 7): NM_207627

Applied Biosystems Silencer® siRNAs for ABCG1

Sigma-Aldrich siRNA for ABCG1

Sigma-Aldrich shRNA for ABCG1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for ABCG1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 6): NM_004915
Myc/DDK tagged cDNA clones in CMV expression vector (see all 6): NM_004915
untagged cDNA clones in CMV expression vector (see all 7): NM_004915

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_004915

UniProtKB/Swiss-Prot: ABCG1_HUMAN, P45844

Function: Transporter involved in macrophage lipid homeostasis. Is an active component of the

macrophage lipid export complex. Could also be involved in intracellular lipid transport

processes. The role in cellular lipid homeostasis may not be limited to macrophages

Induction: Strongly induced in monocyte-derived macrophages during cholesterol influx. Conversely,

mRNA and protein expression are suppressed by lipid efflux. Induction is mediated by the liver X

receptor/retinoid X receptor (LXR/RXR) pathway. Not induced by bacterial lipopolysaccharides

(LPS). Repressed by ZNF202

Genatlas biochemistry entry for ABCG1:

ATP-binding cassette superfamily,subfamily G (WHITE),member 1,homolog of Drosophila White

(W),expresed in cholesterol-laden macrophages,localized at the cell surface or in intracellular

compartments,regulated by cholesterol uptake or HDL-mediated lipid release,potentially involved in

macrophage lipid homeostasis

10 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Abcg1):

adipose tissue	behavior/neurological	cellular	growth/size	hematopoietic system
homeostasis/metabolism	immune system	liver/biliary system	renal/urinary system	respiratory system

5/13 Gene Ontology (GO) molecular function terms (links to tree view) (see all 13 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0005524	ATP binding	IEA	--
GO:0005543	phospholipid binding	IC	16702602
GO:0005548	phospholipid transporter activity	IDA	16702602
GO:0015485	cholesterol binding	IC	15994327

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

2 Sigma-Aldrich "Your Favorite Gene" Pathways for ABCG1 (Your Favorite Gene powered by Ingenuity)

LPS/IL-1 Mediated Inhibition of RXR Function
LXR/RXR Activation

GeneDecks ABCG1 for the pathways selected above

About GeneDecksing

5/11 Interacting proteins for ABCG1 (ENSP00000343820³) via UniProtKB, MINT, and/or STRING (see all 11 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
APOA1	ENSP00000364469³	STRING (score=.957)
ABCG4	ENSP00000304111³	STRING (score=.875)
NR1H3	ENSP00000342470³	STRING (score=.866)
CSF2	ENSP00000296871³	STRING (score=.855)
LSS	ENSP00000348762³	STRING (score=.853)

About this table

5/16 Gene Ontology (GO) biological process terms (links to tree view) (see all 16 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006869	lipid transport	IEA	--
GO:0008203	cholesterol metabolic process	IDA	15994327
GO:0009720	detection of hormone stimulus	NAS	11500512
GO:0010033	response to organic substance	IDA	11500512
GO:0010742	foam cell differentiation	TAS	18490524

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for ABCG1
10/15 Novoseek chemical compound relationships for ABCG1 gene (see all 15 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
24(s),25-epoxycholesterol	87.37	1	17186944 (1)
cholesterol	79.88	207	15994327 (8), 15210959 (6), 16702602 (5), 10639163 (5) (see all 89)
27-hydroxycholesterol	79.25	4	17088262 (3)
22-hydroxycholesterol	77.08	1	16498511 (1)
sterol	75.54	11	10799558 (1), 14993242 (1), 16680026 (1), 18849545 (1) (see all 10)
22r-hydroxycholesterol	73.64	3	10799558 (1), 17478758 (1), 15777536 (1)
essentiale	60.67	2	16702602 (1), 10639163 (1)
lipid	55.24	24	15994327 (3), 16798073 (2), 16680026 (2), 16054053 (2) (see all 15)
3-hydroxy-3-methylglutaryl-coa	44.87	2	16647568 (1)
atp	43.44	21	11279031 (2), 15994327 (2), 16702602 (1), 17408620 (1) (see all 15)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ABCG1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ABCG1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 7): NM_207627

Sigma-Aldrich siRNA for ABCG1

Sigma-Aldrich shRNA for ABCG1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_004915 NM_016818 NM_207174 NM_207627 NM_207628 NM_207629

REFSEQ mRNAs for ABCG1 gene (6 alternative transcripts):

NM_004915.3 NM_016818.2 NM_207174.1 NM_207627.1 NM_207628.1 NM_207629.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_004915 NM_016818 NM_207174 NM_207627 NM_207628 NM_207629

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 6): NM_004915
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 6): NM_004915
                                 untagged cDNA clones in CMV expression vector (see all 7): NM_004915

Additional cDNA sequence:

AF038175.1 AF323660.1 AF323661.1 AF323662.1 AF323663.1 AF323664.1 AK292152.1 AK298491.1

AY048757.1 BC029158.1 X91249.1 Z38010.1

14 DOTS entries:

DT.97841101 DT.99993759 DT.100025709 DT.443043 DT.102825859 DT.97841102 DT.97841100 DT.95270333

DT.100025708 DT.92422733 DT.95199656 DT.121133864 DT.315220 DT.40107841

24/117 AceView cDNA sequences (see all 117 ):

BF435640 CD672447 AA297995 BC029158 AA297906 BE466692 AA297109 AI300841

AU185697 NM_016818 AA748203 BF527440 NM_207628 BI258309 AU119946 Z39977

BU187659 NM_207629 AW083232 AI810215 NM_004915 F08291 NM_207630 AU121706

highest scoring ESTs for ABCG1:

X91249 AA297428 AA609931 AA748203 AA758757 AF038175 AI300841 AI453486 AI589663 AI627264

Unigene Cluster for ABCG1:

ATP-binding cassette, sub-family G (WHITE), member 1

Hs.124649 [show with all ESTs]

Unigene Representative Sequence: AY048757

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for ABCG1 (see all 6 )

ExUns:	1	^	2a	·	2b	·	2c	^	3	^	4	^	5	^	6a	·	6b	^	7	^	8a	·	8b	^	9	^	10a	·	10b	·	10c	^	11a	·	11b	^	12a	·	12b	^	13	^	14
SP1:																							-
SP2:
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for ABCG1

7 Ensembl transcripts including schematic representations:

ENST00000340588 ENST00000343687 ENST00000398449 ENST00000398437 ENST00000361802 ENST00000347800

ENST00000398457

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

ABCG1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ABCG1

¹ / ² / ³

5 probe-sets matching ABCG1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
41362_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	X91249	1.00	0.90	0.95	1
211113_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	U34919	0.40	1.00	0.76	1
204567_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_004915	0.60	1.00	0.82	1
211113_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
204567_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks ABCG1 for binary patterns associated with the probe-sets selected above

About GeneDecksing

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CAGACATTTT

SOURCE GeneReport for Unigene cluster: Hs.124649
Expression variation in blood from EXPOLDB for ABCG1
UniProtKB/Swiss-Prot: ABCG1_HUMAN, P45844
Tissue specificity: Expressed in several tissues

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ABCG1 gene from 5/12 species (see all 12 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ABCG1¹	--	ATP-binding cassette, sub-family G (WHITE), member more	90.24(n) 98.16(a)	487777 XM_544902.2 XP_544902.2
chimpanzee (Pan troglodytes)	ABCG1¹	--	ATP-binding cassette, sub-family G (WHITE), member more	99.5(n) 100(a)	458577 XM_514918.2 XP_514918.2
cow (Bos taurus)	ABCG1¹	--	ATP-binding cassette, sub-family G (WHITE), member more	87.79(n) 95.21(a)	510745 XM_587930.3 XP_587930.3
rat (Rattus norvegicus)	Abcg1¹	--	ATP-binding cassette, sub-family G (WHITE), member more	87.19(n) 96.85(a)	85264 NM_053502.1 NP_445954.1
mouse (Mus musculus)	Abcg1^{1, 5}	17⁵	ATP-binding cassette, sub-family G (WHITE), member more^{1, 5}	87.64(n)¹ 96.85(a)¹	11307¹ NM_009593.1¹ NP_033723.1¹ AF323659⁵ AK037241⁵ (see all 16)

About this table Species with no ortholog for ABCG1

ENSEMBL Gene Tree for ABCG1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for ABCG1 gene

ABCG4²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/665 NCBI SNPs in ABCG1 are shown (see all 665 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 277)

AB	SNP ID	Valid	Chr 21 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs1044317^1,2	A,C,F,H	42589970(+)	`GCTGCG/ACAGTC`	6	--	ut3¹		8		EA NA EU WA	2022
	rs1378577^1,2	A,C,F,H	42492734(-)	`CCCTCA/CCAAGT`	2	--	ng5¹		14		EA NA EU WA	1230
	rs4148095^1,2	C,F,H	42509025(+)	`TCCAAT/CTGGAC`	3	--	int¹ ng5¹		4		EU EA WA	418
	rs2234715^1,2	C,F,H	42511924(+)	`CAGCAA/GGAAAG`	6	--	int¹ ng5¹ trp³		4		EU EA WA	418
	rs692383^1,2	A,C,F	42508243(+)	`GCTGCG/ATGCAG`	3	--	int¹ ng5¹		2		NA	182
	rs915845^1,2	A,F,H	42508507(+)	`CTCAGT/GGTGCC`	3	--	int¹ ng5¹		4		EU EA WA	414
	rs1893590^1,2	A,C,F	42492664(+)	`GAGAGA/CTGGGT`	2	--	ng5¹		3		NA	140
	rs4148082^1,2	C,F,H	42492484(+)	`TAGAGG/ATATTG`	2	--	ng5¹		15		EU EA WA NA	1400
	rs12626718^1,2	C,F,H	42491721(+)	`tttgtA/Gtccac`	2	--	ng5¹		4		EU EA WA	418
	rs564010^1,2	A,C	42511613(-)	`GAGCCA/GTGTTC`	6	--	ng5¹ int¹		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for ABCG1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 603076

UniProtKB/Swiss-Prot: ABCG1_HUMAN, P45844

Overexpressed in macrophages from patients with Tangier disease compared to control

macrophages. Expressed in foamy macrophages within the atherosclerotic plaque. May play a role in

the cholesterol metabolism of macrophages in vitro and in the atherosclerotic plaque

6 Novoseek disease relationships for ABCG1 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
tangier disease	67.94	3	11350058 (2), 11427487 (1)
atherosclerosis	61.89	11	18599800 (3), 17459600 (2), 16680026 (1), 15891397 (1) (see all 7)
cardiovascular diseases	32.38	1	17408620 (1)
atherosclerotic plaque	31.89	2	11350058 (2)
inflammation	3.51	1	18460328 (1)
tumors	2.02	2	16941710 (1), 12874078 (1)

About this table

Genetic Association Database: ABCG1
Human Genome Epidemiology Navigator: ABCG1 (5 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/159 PubMed articles for ABCG1 gene (see all 159 ):

Cloning of the cDNA for a human homologue of the Drosophila white gene and mapping to chromosome 21q22.3. (PubMed id 8659545)^{2, 3, 4} Chen H.M.... Antonarakis S.E. (1996)
ABCG1 (ABC8), the human homolog of the Drosophila white gene, is a regulator of macrophage cholesterol and phospholipid transport. (PubMed id 10639163)^{1, 3, 4} Klucken J.... Schmitz G. (2000)
Expression and functional characterization of ABCG1 splice variant ABCG1(666). (PubMed id 16870176)^{1, 2, 3} Engel T....Seedorf U. (2006)
Expression of the ATP-binding cassette transporter gene ABCG1 (ABC8) in Tangier disease. (PubMed id 11350058)^{1, 3, 4} Lorkowski S.... Cullen P. (2001)
The zinc finger protein 202 (ZNF202) is a transcriptional repressor of ATP binding cassette transporter A1 (ABCA1) and ABCG1 gene expression and a modulator of cellular lipid efflux. (PubMed id 11279031)^{1, 3, 4} Porsch-Oezcueruemez M.... Schmitz G. (2001)
Human white/murine ABC8 mRNA levels are highly induced in lipid- loaded macrophages. A transcriptional role for specific oxysterols. (PubMed id 10799558)^{1, 3, 4} Venkateswaran A.... Edwards P.A. (2000)
Role of ABCG1 and other ABCG family members in lipid metabolism. (PubMed id 11590207)^{1, 3, 4} Schmitz G.... Heimerl S. (2001)
Genomic sequence and structure of the human ABCG1 (ABC8) gene. (PubMed id 11162488)^{1, 3, 4} Lorkowski S.... Cullen P. (2001)
Characterization of the human ABCG1 gene: liver X receptor activates an internal promoter that produces a novel transcript encoding an alternative form of the protein. (PubMed id 11500512)^{1, 3, 4} Kennedy M.A.... Edwards P.A. (2001)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 9619	HGNC: 73	AceView: ABCG1	Ensembl:ENSG00000160179	euGenes: HUgn9619
ECgene: ABCG1	H-InvDB: ABCG1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for ABCG1
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for ABCG1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ABCG1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ABCG1		Antibodies for ABCG1
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for ABCG1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (ABCG1)
	Antibodies (ABCG1)
	Chimera RNAi (ABCG1)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (ABCG1)
	Antibodies (ABCG1)

Search OriGene for ABCG1

Search Tocris compounds for ABCG1

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for ABCG1

GeneCards Homepage - Last full update: 1 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
ABCG1 Gene at Home site.
Version 2.41.1
server5.xennexinc.com

ABCG1 Gene

protein-coding GIFtS: 62

Aliases &
Descriptions
for ABCG1

Summaries
for ABCG1

Genomic Location
for ABCG1

Proteins
for ABCG1

Protein Domains/
Families
for ABCG1

Gene Function
for ABCG1

Pathways & Interactions
for ABCG1

Drugs & Compounds
for ABCG1

Transcripts
for ABCG1

Expression
for ABCG1

Orthologs
for ABCG1

Paralogs
for ABCG1

SNPs/Variants
for ABCG1

Disorders & Mutations
for ABCG1

Medical News
for ABCG1

Publications
for ABCG1

Search for ABCG1

Genome Databases showing ABCG1

Other Databases showing ABCG1

Specialized Databases showing ABCG1

Licensable Technologies
for ABCG1

Services
for ABCG1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ABCG1 Gene

protein-coding GIFtS: 62

Aliases & Descriptionsfor ABCG1

Summariesfor ABCG1

Genomic Locationfor ABCG1

Proteinsfor ABCG1

Protein Domains/Familiesfor ABCG1

Gene Functionfor ABCG1

Pathways & Interactionsfor ABCG1

Drugs & Compoundsfor ABCG1

Transcriptsfor ABCG1

Expression for ABCG1

Orthologsfor ABCG1

Paralogsfor ABCG1

SNPs/Variantsfor ABCG1

Disorders & Mutationsfor ABCG1

Medical Newsfor ABCG1

Publicationsfor ABCG1

Search for ABCG1

Genome Databases showing ABCG1

Other Databases showing ABCG1

Specialized Databases showing ABCG1

Licensable Technologiesfor ABCG1

Servicesfor ABCG1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ABCG1

Summaries
for ABCG1

Genomic Location
for ABCG1

Proteins
for ABCG1

Protein Domains/
Families
for ABCG1

Gene Function
for ABCG1

Pathways & Interactions
for ABCG1

Drugs & Compounds
for ABCG1

Transcripts
for ABCG1

Expression
for ABCG1

Orthologs
for ABCG1

Paralogs
for ABCG1

SNPs/Variants
for ABCG1

Disorders & Mutations
for ABCG1

Medical News
for ABCG1

Publications
for ABCG1

Licensable Technologies
for ABCG1

Services
for ABCG1