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Aliases & Descriptions for ABCG1
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase , and/or 9 Nature :405,311-319 and CroW21)About This Section
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Aliases ABC8 1 , 2 , 3 , 5 MGC34313 2 OTTHUMP00000109322 2 WHITE1 2 , 5 WHT1 3
Descriptions ABC transporter 8 2 ATP-binding cassette sub-family G member 1 2 ATP-binding cassette transporter 8 2 , 3 ATP-binding cassette transporter member 1 of subfamily G 2 ATP-binding cassette, sub-family G (WHITE), member 1 2 ATP-binding cassette, sub-family G, member 1 1 White protein homolog 3 homolog of Drosophila white 2 white protein homolog (ATP-binding cassette transporter 8) 2 , 9
Search outside databases for aliases for ABCG1 genePrevious GC identifers: GC21P040187 GC21P042514 GC21P042533 GC21P042496
Summaries for ABCG1 (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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EntrezGene summary for ABCG1 : The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC)transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes.ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20,White). This protein is a member of the White subfamily. It is involved in macrophage cholesteroland phospholipids transport, and may regulate cellular lipid homeostasis in other cell types. Sixalternative splice variants have been identified. [provided by RefSeq] UniProtKB/Swiss-Prot: ABCG1_HUMAN, P45844 Function : Transporter involved in macrophage lipid homeostasis. Is an active component of themacrophage lipid export complex. Could also be involved in intracellular lipid transportprocesses. The role in cellular lipid homeostasis may not be limited to macrophages
Gene Wiki entry for ABCG1
Genomic Location for ABCG1
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
SABiosciences , Whole Chromsome Sequence According to
Nature (Cited Here with Permission) :405,311-319 and CroW21)About This Section
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Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 21q22.3 Ensembl cytogenetic band: 21q22.3 HGNC cytogenetic band: 21q22.3 Nature(405: 311-319) cytogenetic band: 21q22.3 ABCG1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
GC21P042492:
GeneLoc
Nature :405,311-319
Start:
42,492,868 bp from pter
29,186,705 bp from centromere
End:
42,590,423 bp from pter
29,264,680 bp from centromere
Size:
97,556 bases
77,976 bases
Orientation:
plus strand
plus strand
RefSeq DNA sequence: NC_000021.7 NT_030188.4 Proteins for ABCG1
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: ABCG1_HUMAN, P45844 (See
protein sequence )Recommended Name: ATP-binding cassette sub-family G member 1 Size : 678 amino acids; 75592 Da
Subunit : May form heterodimers with several heterologous partners of the ABCG subfamily
Subcellular location : Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatusmembrane; Multi-pass membrane protein. Note=Predominantly localized in the intracellularcompartments mainly associated with the endoplasmic reticulum (ER) and Golgi membranes
Secondary accessions : Q86SU8 Q96L76 Q9BXK6 Q9BXK7 Q9BXK8 Q9BXK9 Q9BXL0 Q9BXL1 Q9BXL2 Q9BXL3 Q9BXL4Alternative splicing : 8 isoforms : P45844-1 P45844-2 P45844-3 P45844-4 P45844-5 P45844-6 P45844-7 P45844-8 (Additional isoforms seem to exist)
REFSEQ proteins (6 alternative transcripts):
NP_004906.3 NP_058198.2 NP_997057.1 NP_997510.1 NP_997511.1 NP_997512.1 ENSEMBL proteins: ENSP00000343820 ENSP00000339744 ENSP00000381467 ENSP00000381464 ENSP00000354995 ENSP00000291524 ENSP00000381475 Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 5/7 Gene Ontology (GO) cellular component terms (links to tree view) (see all 7
):
About this table Antibodies for ABCG1: Assays for ABCG1:
Protein
Domains/ Families for ABCG1(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry P45844 ProtoNet protein and cluster: P45844
UniProtKB/Swiss-Prot: ABCG1_HUMAN, P45844 Similarity : Belongs to the ABC transporter family. ABCG (White) subfamilySimilarity : Contains 1 ABC transmembrane type-2 domainSimilarity : Contains 1 ABC transporter domain
Gene Function for ABCG1
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
OriGene ,
Sigma-Aldrich , RNAi from
Sigma-Aldrich ,
RNAi Products ,
Clones , and
Q-PCR Products
from Invitrogen ,
Millipore ,
OriGene , and/or
Abnova ,
siRNAs from
Applied Biosystems ,
SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 7 ): NM_207627 Applied Biosystems Silencer ® siRNAs for ABCG1 Sigma-Aldrich siRNA for ABCG1 Sigma-Aldrich shRNA for ABCG1 Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 6 ): NM_004915                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 6 ): NM_004915                                  untagged cDNA clones in CMV expression vector (see all 7 ): NM_004915  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_004915 UniProtKB/Swiss-Prot: ABCG1_HUMAN, P45844 Function : Transporter involved in macrophage lipid homeostasis. Is an active component of themacrophage lipid export complex. Could also be involved in intracellular lipid transportprocesses. The role in cellular lipid homeostasis may not be limited to macrophages Induction : Strongly induced in monocyte-derived macrophages during cholesterol influx. Conversely,mRNA and protein expression are suppressed by lipid efflux. Induction is mediated by the liver Xreceptor/retinoid X receptor (LXR/RXR) pathway. Not induced by bacterial lipopolysaccharides(LPS). Repressed by ZNF202
Genatlas biochemistry entry for ABCG1 :ATP-binding cassette superfamily,subfamily G (WHITE),member 1,homolog of Drosophila White(W),expresed in cholesterol-laden macrophages,localized at the cell surface or in intracellularcompartments,regulated by cholesterol uptake or HDL-mediated lipid release,potentially involved inmacrophage lipid homeostasis
10 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Abcg1) :5/13 Gene Ontology (GO) molecular function terms (links to tree view) (see all 13
):
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Pathways & Interactions for ABCG1
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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2 Sigma-Aldrich "Your Favorite Gene" Pathways for ABCG1 (Your Favorite Gene powered by Ingenuity) 5/11 Interacting proteins for ABCG1 (ENSP00000343820 3 ) via UniProtKB, MINT, and/or STRING (see all 11
)About this table 5/16 Gene Ontology (GO) biological process terms (links to tree view) (see all 16
):
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Drugs & Compounds for ABCG1 (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Browse Tocris compounds for ABCG1 10/15 Novoseek chemical compound relationships for ABCG1 gene (see all 15
)
Compound
Score
Articles
PubMed IDs for Articles with Shared Sentences (# sentences)
24(s),25-epoxycholesterol
87.37
1
17186944 (1)
cholesterol
79.88
207
15994327 (8), 15210959 (6), 16702602 (5), 10639163 (5) (see all 89 )
27-hydroxycholesterol
79.25
4
17088262 (3)
22-hydroxycholesterol
77.08
1
16498511 (1)
sterol
75.54
11
10799558 (1), 14993242 (1), 16680026 (1), 18849545 (1) (see all 10 )
22r-hydroxycholesterol
73.64
3
10799558 (1), 17478758 (1), 15777536 (1)
essentiale
60.67
2
16702602 (1), 10639163 (1)
lipid
55.24
24
15994327 (3), 16798073 (2), 16680026 (2), 16054053 (2) (see all 15 )
3-hydroxy-3-methylglutaryl-coa
44.87
2
16647568 (1)
atp
43.44
21
11279031 (2), 15994327 (2), 16702602 (1), 17408620 (1) (see all 15 )
About this table
Transcripts for ABCG1(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
Millipore , and/or
Abnova ,
siRNAs from Applied Biosystems ,
Sigma-Aldrich ,
shRNA from
Sigma-Aldrich ,
OriGene ,
Tagged/untagged cDNA clones from
OriGene , Expression Assays from Applied Biosystems )About This Section
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 7 ): NM_207627 Sigma-Aldrich siRNA for ABCG1 Sigma-Aldrich shRNA for ABCG1 Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_004915 NM_016818 NM_207174 NM_207627 NM_207628 NM_207629
REFSEQ mRNAs for ABCG1 gene (6 alternative transcripts): NM_004915.3 NM_016818.2 NM_207174.1 NM_207627.1 NM_207628.1 NM_207629.1
Applied Biosystems TaqMan ® Gene Expression Assays: NM_004915 NM_016818 NM_207174 NM_207627 NM_207628 NM_207629
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 6 ): NM_004915                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 6 ): NM_004915                                  untagged cDNA clones in CMV expression vector (see all 7 ): NM_004915  
Additional cDNA sequence: AF038175.1 AF323660.1 AF323661.1 AF323662.1 AF323663.1 AF323664.1 AK292152.1 AK298491.1 AY048757.1 BC029158.1 X91249.1 Z38010.1
14 DOTS entries : DT.97841101 DT.99993759 DT.100025709 DT.443043 DT.102825859 DT.97841102 DT.97841100 DT.95270333 DT.100025708 DT.92422733 DT.95199656 DT.121133864 DT.315220 DT.40107841
24/117 AceView cDNA sequences (see all 117
):BF435640 CD672447 AA297995 BC029158 AA297906 BE466692 AA297109 AI300841 AU185697 NM_016818 AA748203 BF527440 NM_207628 BI258309 AU119946 Z39977 BU187659 NM_207629 AW083232 AI810215 NM_004915 F08291 NM_207630 AU121706
highest scoring ESTs for ABCG1 :X91249 AA297428 AA609931 AA748203 AA758757 AF038175 AI300841 AI453486 AI589663 AI627264
Unigene Cluster for ABCG1: ATP-binding cassette, sub-family G (WHITE), member 1 Hs.124649 [show with all ESTs ] Unigene Representative Sequence: AY048757 GeneLoc Exon Structure 5/6 Alternative Splicing Database (ASD) splice patterns (SP) for ABCG1 (see all 6
) ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 SP1 :                       -                       SP2 :                                             SP3 :                                             SP4 :                                             SP5 :                                            
About this scheme ECgene alternative splicing isoforms for ABCG1 7 Ensembl transcripts including schematic representations : ENST00000340588
ENST00000343687
ENST00000398449
ENST00000398437
ENST00000361802
ENST00000347800
ENST00000398457
Expression for ABCG1
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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ABCG1 expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for ABCG1 1 / 2 / 3
5 probe-sets matching ABCG1 gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: CAGACATTTTSOURCE GeneReport for Unigene cluster: Hs.124649 Expression variation in blood from EXPOLDB for ABCG1
UniProtKB/Swiss-Prot: ABCG1_HUMAN, P45844 Tissue specificity : Expressed in several tissues
Orthologs for ABCG1
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for ABCG1 gene from 5/12 species (see all 12
)
Organism
Gene
Locus
Description
Human Similarity
NCBI accessions
dog (Canis familiaris)
ABCG11
--
ATP-binding cassette, sub-family G (WHITE), member more
90.24(n) 98.16(a)
487777 XM_544902.2 XP_544902.2
chimpanzee (Pan troglodytes)
ABCG11
--
ATP-binding cassette, sub-family G (WHITE), member more
99.5(n) 100(a)
458577 XM_514918.2 XP_514918.2
cow (Bos taurus)
ABCG11
--
ATP-binding cassette, sub-family G (WHITE), member more
87.79(n) 95.21(a)
510745 XM_587930.3 XP_587930.3
rat (Rattus norvegicus)
Abcg11
--
ATP-binding cassette, sub-family G (WHITE), member more
87.19(n) 96.85(a)
85264 NM_053502.1 NP_445954.1
mouse (Mus musculus)
Abcg11 , 5
175
ATP-binding cassette, sub-family G (WHITE), member more 1, 5
87.64(n) 1 96.85(a) 1
11307 1 NM_009593.1 1 NP_033723.1 1 AF323659 5 AK037241 5 (see all 16 )
About this table Species with no ortholog for ABCG1 ENSEMBL Gene Tree for ABCG1 Paralogs for ABCG1 (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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Paralogs for ABCG1 gene ABCG4 2
SNPs/Variants for ABCG1 (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for ABCG1 (up to first 250kb)
Disorders & Mutations for ABCG1
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
Novoseek , PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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OMIM: 603076 UniProtKB/Swiss-Prot: ABCG1_HUMAN, P45844
Overexpressed in macrophages from patients with Tangier disease compared to controlmacrophages. Expressed in foamy macrophages within the atherosclerotic plaque. May play a role inthe cholesterol metabolism of macrophages in vitro and in the atherosclerotic plaque
6 Novoseek disease relationships for ABCG1 gene
About this table Genetic Association Database: ABCG1 Human Genome Epidemiology Navigator: ABCG1 (5 documents)
Medical News for ABCG1 (Possibly Related Articles in
Doctor's Guide )
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--
Publications for ABCG1 (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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10/159 PubMed articles for ABCG1 gene (see all 159
): Cloning of the cDNA for a human homologue of the Drosophila white gene and mapping to chromosome 21q22.3. (PubMed id 8659545) 2, 3, 4 Chen H.M.... Antonarakis S.E. (1996) ABCG1 (ABC8), the human homolog of the Drosophila white gene, is a regulator of macrophage cholesterol and phospholipid transport. (PubMed id 10639163) 1, 3, 4 Klucken J.... Schmitz G. (2000) Expression and functional characterization of ABCG1 splice variant ABCG1(666). (PubMed id 16870176) 1, 2, 3 Engel T....Seedorf U. (2006) Expression of the ATP-binding cassette transporter gene ABCG1 (ABC8) in Tangier disease. (PubMed id 11350058) 1, 3, 4 Lorkowski S.... Cullen P. (2001) The zinc finger protein 202 (ZNF202) is a transcriptional repressor of ATP binding cassette transporter A1 (ABCA1) and ABCG1 gene expression and a modulator of cellular lipid efflux. (PubMed id 11279031) 1, 3, 4 Porsch-Oezcueruemez M.... Schmitz G. (2001) Human white/murine ABC8 mRNA levels are highly induced in lipid- loaded macrophages. A transcriptional role for specific oxysterols. (PubMed id 10799558) 1, 3, 4 Venkateswaran A.... Edwards P.A. (2000) Role of ABCG1 and other ABCG family members in lipid metabolism. (PubMed id 11590207) 1, 3, 4 Schmitz G.... Heimerl S. (2001) Genomic sequence and structure of the human ABCG1 (ABC8) gene. (PubMed id 11162488) 1, 3, 4 Lorkowski S.... Cullen P. (2001) Characterization of the human ABCG1 gene: liver X receptor activates an internal promoter that produces a novel transcript encoding an alternative form of the protein. (PubMed id 11500512) 1, 3, 4 Kennedy M.A.... Edwards P.A. (2001) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 3, 4 Gerhard D.S....Malek J. (2004)
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Genome Databases showing ABCG1
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
H-InvDB )
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Other Databases showing ABCG1
(According to HUGE )
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Specialized Databases showing ABCG1 (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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-- Services for ABCG1 (Reagents available from Applied Biosystems , Antibodies and assays by Cell
Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
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Products for ABCG1:
Search Tocris compounds for ABCG1
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GeneCards Homepage - Last full update: 1 Jul 2009
Incremental update: 13 Oct 2009