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Aliases for ABCF3 Gene

Aliases for ABCF3 Gene

  • ATP Binding Cassette Subfamily F Member 3 2 3 5
  • ATP-Binding Cassette, Sub-Family F (GCN20), Member 3 2 3
  • ATP-Binding Cassette Sub-Family F Member 3 3
  • EC 3.6.3.17 61
  • EST201864 3
  • EC 3.6.3 61

External Ids for ABCF3 Gene

Previous GeneCards Identifiers for ABCF3 Gene

  • GC03U990120
  • GC03P185305
  • GC03P185224
  • GC03P185386
  • GC03P183903
  • GC03P181310

Summaries for ABCF3 Gene

Entrez Gene Summary for ABCF3 Gene

  • This gene encodes a member of the ATP-binding cassette (ABC) transporter superfamily. ATP-binding cassette proteins transport various molecules across extra- and intracellular membranes. The protein encoded by this gene displays antiviral effect against flaviviruses. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2017]

GeneCards Summary for ABCF3 Gene

ABCF3 (ATP Binding Cassette Subfamily F Member 3) is a Protein Coding gene. Diseases associated with ABCF3 include West Nile Virus. GO annotations related to this gene include ATPase activity. An important paralog of this gene is ABCF1.

UniProtKB/Swiss-Prot for ABCF3 Gene

  • Displays an antiviral effect against flaviviruses such as west Nile virus (WNV) in the presence of OAS1B.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ABCF3 Gene

Genomics for ABCF3 Gene

Regulatory Elements for ABCF3 Gene

Enhancers for ABCF3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03G184171 1.6 Ensembl ENCODE dbSUPER 13.5 -10.9 -10862 8.0 HDGF CREB3L1 AGO1 ARID4B SIN3A DMAP1 YY1 ZNF766 ZNF143 FOS VWA5B2 ABCF3 EIF2B5 DVL3 ALG3 ECE2 MIR1224 CAMK2N2 AP2M1
GH03G184184 1.4 ENCODE dbSUPER 12.7 +0.1 75 3.6 HDGF PKNOX1 CREB3L1 AGO1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 YY1 VWA5B2 POLR2H ABCF3 EIF2B5 ALG3 ECE2 MIR1224 CAMK2N2 PSMD2 EIF4G1
GH03G184154 1.3 ENCODE dbSUPER 10.6 -29.6 -29627 4.2 HDGF ARID4B SIN3A DMAP1 SLC30A9 ZNF143 KLF13 SP3 SP5 MXD4 EIF2B5 ALG3 ECE2 ABCF3 CAMK2N2 PSMD2 VWA5B2 MIR1224 EIF4G1 SNORD66
GH03G184330 1.3 ENCODE dbSUPER 10.1 +149.4 149382 9.0 PKNOX1 FOXA2 CREB3L1 AGO1 ARID4B SIN3A DMAP1 YY1 ZNF143 FOS ABCF3 PSMD2 VWA5B2 ECE2 DVL3 FAM131A SNORD66
GH03G184160 1.2 Ensembl ENCODE dbSUPER 10.8 -25.2 -25166 1.6 HDAC1 FOXA2 CEBPG GATA2 EED FOS L3MBTL2 BHLHE40 E2F5 JUNB EIF2B5 ABCF3 CAMK2N2 ALG3 ECE2 VWA5B2 MIR1224 EIF4G1 SNORD66 PSMD2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ABCF3 on UCSC Golden Path with GeneCards custom track

Promoters for ABCF3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000162894 377 1201 HDGF PKNOX1 CREB3L1 AGO1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 YY1

Genomic Location for ABCF3 Gene

Chromosome:
3
Start:
184,186,023 bp from pter
End:
184,194,452 bp from pter
Size:
8,430 bases
Orientation:
Plus strand

Genomic View for ABCF3 Gene

Genes around ABCF3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ABCF3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ABCF3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ABCF3 Gene

Proteins for ABCF3 Gene

  • Protein details for ABCF3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NUQ8-ABCF3_HUMAN
    Recommended name:
    ATP-binding cassette sub-family F member 3
    Protein Accession:
    Q9NUQ8
    Secondary Accessions:
    • A8K241
    • Q86UA2
    • Q8NAN1
    • Q96GS8
    • Q9H7A8

    Protein attributes for ABCF3 Gene

    Size:
    709 amino acids
    Molecular mass:
    79745 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB14989.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ABCF3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ABCF3 Gene

Selected DME Specific Peptides for ABCF3 Gene

Q9NUQ8:
  • NGAGKST
  • GENGAGKST
  • LLLLDEP

Post-translational modifications for ABCF3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ABCF3 Gene

Domains & Families for ABCF3 Gene

Gene Families for ABCF3 Gene

Suggested Antigen Peptide Sequences for ABCF3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NUQ8

UniProtKB/Swiss-Prot:

ABCF3_HUMAN :
  • Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily.
Family:
  • Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily.
genes like me logo Genes that share domains with ABCF3: view

Function for ABCF3 Gene

Molecular function for ABCF3 Gene

GENATLAS Biochemistry:
ATP-binding cassette superfamily,subfamily F (GCN20),member 3
UniProtKB/Swiss-Prot Function:
Displays an antiviral effect against flaviviruses such as west Nile virus (WNV) in the presence of OAS1B.

Enzyme Numbers (IUBMB) for ABCF3 Gene

Gene Ontology (GO) - Molecular Function for ABCF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21516116
GO:0005524 ATP binding IEA --
GO:0016887 ATPase activity IEA --
GO:0045296 cadherin binding IDA 25468996
genes like me logo Genes that share ontologies with ABCF3: view

Phenotypes for ABCF3 Gene

genes like me logo Genes that share phenotypes with ABCF3: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ABCF3

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ABCF3 Gene

Localization for ABCF3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ABCF3 gene
Compartment Confidence
cytosol 4
nucleus 3

Gene Ontology (GO) - Cellular Components for ABCF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with ABCF3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ABCF3 Gene

Pathways & Interactions for ABCF3 Gene

SuperPathways for ABCF3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ABCF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051607 defense response to virus IEA --
genes like me logo Genes that share ontologies with ABCF3: view

No data available for Pathways by source and SIGNOR curated interactions for ABCF3 Gene

Drugs & Compounds for ABCF3 Gene

No Compound Related Data Available

Transcripts for ABCF3 Gene

Unigene Clusters for ABCF3 Gene

ATP-binding cassette, sub-family F (GCN20), member 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ABCF3 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b · 6c · 6d ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^
SP1: - - - -
SP2: - - - - -
SP3: - -
SP4:
SP5: - - -
SP6: - - - -
SP7: - - - - -
SP8: - - - - -
SP9: - - -
SP10:
SP11:
SP12: - - - - - -
SP13: - -
SP14: -
SP15: - - -
SP16: - - - - - - - - - -
SP17:
SP18:
SP19:
SP20:

ExUns: 14a · 14b · 14c · 14d ^ 15a · 15b · 15c ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21 ^ 22a · 22b
SP1: - -
SP2: - -
SP3: - -
SP4: - -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20: -

Relevant External Links for ABCF3 Gene

GeneLoc Exon Structure for
ABCF3
ECgene alternative splicing isoforms for
ABCF3

Expression for ABCF3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ABCF3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ABCF3 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (15.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ABCF3 Gene



Protein tissue co-expression partners for ABCF3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ABCF3 Gene:

ABCF3

SOURCE GeneReport for Unigene cluster for ABCF3 Gene:

Hs.361323

Evidence on tissue expression from TISSUES for ABCF3 Gene

  • Nervous system(4.9)
  • Muscle(4.3)
  • Skin(4.3)
genes like me logo Genes that share expression patterns with ABCF3: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ABCF3 Gene

Orthologs for ABCF3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ABCF3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ABCF3 34 35
  • 99.72 (n)
oppossum
(Monodelphis domestica)
Mammalia ABCF3 35
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ABCF3 34 35
  • 92.67 (n)
cow
(Bos Taurus)
Mammalia ABCF3 34 35
  • 91.77 (n)
rat
(Rattus norvegicus)
Mammalia Abcf3 34
  • 88.53 (n)
mouse
(Mus musculus)
Mammalia Abcf3 34 16 35
  • 88.34 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ABCF3 35
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves ABCF3 34 35
  • 76.45 (n)
lizard
(Anolis carolinensis)
Reptilia ABCF3 35
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100145696 34
  • 70.29 (n)
African clawed frog
(Xenopus laevis)
Amphibia LOC398565 34
zebrafish
(Danio rerio)
Actinopterygii ABCF3 35
  • 76 (a)
OneToOne
LOC100331227 34
  • 74.37 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012005 34
  • 60.88 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG9330 34 35
  • 59.62 (n)
worm
(Caenorhabditis elegans)
Secernentea abcf-3 34 35
  • 53.4 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AEL032W 34
  • 51.41 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GCN20 34 35 37
  • 51.27 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A10857g 34
  • 49.53 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons GCN3 34
  • 49.98 (n)
soybean
(Glycine max)
eudicotyledons Gma.4290 34
rice
(Oryza sativa)
Liliopsida Os.10758 34
corn
(Zea mays)
Liliopsida Zm.4768 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1523 35
  • 57 (a)
OneToOne
bread mold
(Neurospora crassa)
Ascomycetes NCU04051 34
  • 53.88 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC29A3.09c 34
  • 50.22 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.11475 34
Species where no ortholog for ABCF3 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ABCF3 Gene

ENSEMBL:
Gene Tree for ABCF3 (if available)
TreeFam:
Gene Tree for ABCF3 (if available)

Paralogs for ABCF3 Gene

Paralogs for ABCF3 Gene

(2) SIMAP similar genes for ABCF3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ABCF3: view

Variants for ABCF3 Gene

Sequence variations from dbSNP and Humsavar for ABCF3 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs143852274 Uncertain significance 184,189,867(+) TTGAC(C/T)GGTTT reference, missense
rs1000284977 -- 184,184,665(+) CAGCA(C/T)TCTGG upstream-variant-2KB
rs1000401479 -- 184,184,938(+) AATAT(A/G)ATGAA upstream-variant-2KB
rs1000628076 -- 184,190,250(+) ATCCA(G/T)ATTGT intron-variant
rs1000855803 -- 184,192,210(+) CATGC(A/G)TGTAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ABCF3 Gene

Variant ID Type Subtype PubMed ID
nsv829812 CNV loss 17160897

Variation tolerance for ABCF3 Gene

Residual Variation Intolerance Score: 26.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.80; 58.27% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ABCF3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ABCF3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ABCF3 Gene

Disorders for ABCF3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ABCF3 Gene - From: GeneCards

Disorder Aliases PubMed IDs
west nile virus
  • west nile virus, susceptibility to
- elite association - COSMIC cancer census association via MalaCards
Search ABCF3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for ABCF3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ABCF3
genes like me logo Genes that share disorders with ABCF3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ABCF3 Gene

Publications for ABCF3 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Characterization of the human ABC superfamily: isolation and mapping of 21 new genes using the expressed sequence tags database. (PMID: 8894702) Allikmets R. … Dean M. (Hum. Mol. Genet. 1996) 2 3 64
  4. Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing. (PMID: 26871637) Yang X. … Vidal M. (Cell 2016) 3 64
  5. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X. … Chen J. (Mol. Syst. Biol. 2015) 3 64

Products for ABCF3 Gene

Sources for ABCF3 Gene

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