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ABCF2 Gene

protein-coding   GIFtS: 61
GCID: GC07M150904

ATP-Binding Cassette, Sub-Family F (GCN20), Member 2

  See ABCF2-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
ATP-Binding Cassette, Sub-Family F (GCN20), Member 21 2     ABC-Type Transport Protein2
Iron-Inhibited ABC Transporter 22 3     ATP-Binding Cassette Sub-Family F Member 22
HUSSY182 5     EC 3.6.38
ABC282     EC 3.6.3.178
EST1330902     

External Ids:    HGNC: 711   Entrez Gene: 100612   Ensembl: ENSG000000330507   OMIM: 6125105   UniProtKB: Q9UG633   

Export aliases for ABCF2 gene to outside databases

Previous GC identifers: GC07M149151 GC07M150219 GC07M150296 GC07M150342 GC07M150535 GC07M144715


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ABCF2 Gene:
This gene encodes a member of the ATP-binding cassette (ABC) transporter superfamily. ATP-binding casette proteins
transport various molecules across extra- and intracellular membranes. Alterations in this gene may be involved
in cancer progression. Alternative splicing results in multiple transcript variants. Related pseudogenes have
been identified on chromosomes 3 and 7. (provided by RefSeq, Jul 2013)

GeneCards Summary for ABCF2 Gene:
ABCF2 (ATP-binding cassette, sub-family F (GCN20), member 2) is a protein-coding gene. Diseases associated with ABCF2 include cystic fibrosis. GO annotations related to this gene include ATPase activity and transporter activity.

Gene Wiki entry for ABCF2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NT_007933.16  NC_018918.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ABCF2 gene promoter:
         E2F-4   E2F-3a   E2F-5   MyoD   E2F-2   E2F-1   E2F   Ik-2   SEF-1 (1)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidABCF2 promoter sequence
   Search Chromatin IP Primers for ABCF2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ABCF2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q36   Ensembl cytogenetic band:  7q36.1   HGNC cytogenetic band: 7q36.1

ABCF2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ABCF2 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M150904:  view genomic region     (about GC identifiers)

Start:
150,904,923 bp from pter      End:
150,924,317 bp from pter
Size:
19,395 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 150,234,460-150,253,851     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ABCF2_HUMAN, Q9UG63 (See protein sequence)
Recommended Name: ATP-binding cassette sub-family F member 2  
Size: 623 amino acids; 71290 Da
Caution: Lacks transmembrane domains and is probably not involved in transport
Secondary accessions: O60864 Q75MJ0 Q96TE8

Explore the universe of human proteins at neXtProt for ABCF2: NX_Q9UG63

Explore proteomics data for ABCF2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys315, Lys339, Lys365, Lys436, Lys508, Lys602, Lys618
  • Modification sites at PhosphoSitePlus
  • 3 DME Specific Peptides for ABCF2 (Q9UG63)
     NGAGKST  GPNGAGKS  NGAGKSTLLK 


    See ABCF2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_005683.2  NP_009120.1  

    ENSEMBL proteins: 
     ENSP00000222388   ENSP00000287844   ENSP00000419720   ENSP00000395785  

    ABCF2 Human Recombinant Protein Products:

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    GenScript Custom Purified and Recombinant Proteins Services for ABCF2
    Novus Biologicals ABCF2 Proteins
    Novus Biologicals ABCF2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ABCF2

     
    Search eBioscience for Proteins for ABCF2 

     
    antibodies-online proteins for ABCF2 (6 products) 

     
    antibodies-online peptides for ABCF2

    ABCF2 Antibody Products:

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    antibodies-online antibodies for ABCF2 (70 products) 

    ABCF2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for ABCF2
    Cloud-Clone Corp. CLIAs for ABCF2
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    antibodies-online kits for ABCF2 (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ABCF: ATP binding cassette transporters / subfamily F

    4 InterPro protein domains:
     IPR003439 ABC_transporter-like
     IPR027417 P-loop_NTPase
     IPR003593 AAA+_ATPase
     IPR017871 ABC_transporter_CS

    Graphical View of Domain Structure for InterPro Entry Q9UG63

    ProtoNet protein and cluster: Q9UG63

    UniProtKB/Swiss-Prot: ABCF2_HUMAN, Q9UG63
    Similarity: Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily
    Similarity: Contains 2 ABC transporter domains


    Find genes that share domains with ABCF2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:
         Genatlas biochemistry entry for ABCF2:
    ATP-binding cassette superfamily,subfamily F (GCN20),member 2

         Enzyme Numbers (IUBMB): EC 3.6.32 EC 3.6.3.172

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding ----
    GO:0005215transporter activity TAS9878413
    GO:0005524ATP binding IEA--
    GO:0016887ATPase activity IEA--
    GO:0017111nucleoside-triphosphatase activity ----
         
    Find genes that share ontologies with ABCF2           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for ABCF2:
     Cell cycle / mitosis defect 

         1 MGI phenotypic allele for Abcf2 (no phenotypes)

    Find genes that share phenotypes with ABCF2           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ABCF2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ABCF2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ABCF2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ABCF2

    miRNA
    Products:
        
    miRTarBase miRNAs that target ABCF2:
    hsa-mir-124-3p (MIRT022795), hsa-mir-320a (MIRT044699), hsa-mir-326 (MIRT043643), hsa-mir-193b-3p (MIRT041242), hsa-mir-16-5p (MIRT001483), hsa-mir-186-5p (MIRT045211), hsa-mir-32-5p (MIRT028324), hsa-mir-103a-3p (MIRT027088), hsa-mir-532-3p (MIRT037919)

    Block miRNA regulation of human, mouse, rat ABCF2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ABCF2 (see all 9):
    hsa-miR-433 hsa-miR-588 hsa-miR-1206 hsa-miR-16-1* hsa-miR-944 hsa-miR-548s hsa-miR-4267 hsa-miR-1322
    SwitchGear 3'UTR luciferase reporter plasmidABCF2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ABCF2
    Predesigned siRNA for gene silencing in human, mouse, rat ABCF2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ABCF2

    Clone
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    OriGene clones in human, mouse for ABCF2 (see all 11)
    OriGene ORF clones in mouse, rat for ABCF2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ABCF2 (NM_005692)
    Sino Biological Human cDNA Clone for ABCF2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ABCF2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ABCF2

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for ABCF2
    Browse ESI BIO Cell Lines and PureStem Progenitors for ABCF2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ABCF2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion4
    nucleus3
    cytosol2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion ----
    GO:0005740mitochondrial envelope TAS9878413
    GO:0043190ATP-binding cassette (ABC) transporter complex TAS9878413

    Find genes that share ontologies with ABCF2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ABCF2
    Interactions:

        Search GeneGlobe Interaction Network for ABCF2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ABCF2 (Q9UG633 ENSP000002223884) via UniProtKB, MINT, STRING, and/or I2D (see all 169)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000204221O152133, ENSP000003994544I2D: score=1 STRING: ENSP00000399454
    ENSG00000236222O152133, ENSP000004028694I2D: score=1 STRING: ENSP00000402869
    ENSG00000206284O152133, ENSP000003726954I2D: score=1 STRING: ENSP00000372695
    ENSG00000226916O152133, ENSP000004056144I2D: score=1 STRING: ENSP00000405614
    WDR46O152133, ENSP000003637464I2D: score=1 STRING: ENSP00000363746
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport TAS9878413

    Find genes that share ontologies with ABCF2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ABCF2

    1 Novoseek inferred chemical compound relationship for ABCF2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mitoxantrone 57.9 1 12145683 (1)



    Find genes that share compounds with ABCF2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ABCF2 gene (2 alternative transcripts): 
    NM_005692.4  NM_007189.2  

    Unigene Cluster for ABCF2:

    ATP-binding cassette, sub-family F (GCN20), member 2
    Hs.654958  [show with all ESTs]
    Unigene Representative Sequence: NM_007189
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000222388(uc003wjo.1) ENST00000287844(uc003wjp.3) ENST00000473874
    ENST00000468073 ENST00000441774 ENST00000477252
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ABCF2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ABCF2 (see all 9):
    hsa-miR-433 hsa-miR-588 hsa-miR-1206 hsa-miR-16-1* hsa-miR-944 hsa-miR-548s hsa-miR-4267 hsa-miR-1322
    SwitchGear 3'UTR luciferase reporter plasmidABCF2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ABCF2
    Predesigned siRNA for gene silencing in human, mouse, rat ABCF2
    Clone
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    OriGene clones in human, mouse for ABCF2 (see all 11)
    OriGene ORF clones in mouse, rat for ABCF2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ABCF2 (NM_005692)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ABCF2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ABCF2
    Primer
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    OriGene qPCR primer pairs and template standards for ABCF2
    OriGene qSTAR qPCR primer pairs in human, mouse for ABCF2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ABCF2
      QuantiTect SYBR Green Assays in human, mouse, rat ABCF2
      QuantiFast Probe-based Assays in human, mouse, rat ABCF2

    Additional mRNA sequence: 

    AF091073.1 AF261091.1 AF261092.1 AJ005016.1 AL050291.1 AY927508.1 AY927589.1 BC001661.2 
    BT007451.1 

    11 DOTS entries:

    DT.216455  DT.95247991  DT.100694667  DT.100786071  DT.100029672  DT.95247982  DT.92444720  DT.120878004 
    DT.92444716  DT.95254420  DT.100786067 

    Selected AceView cDNA sequences (see all 344):

    AW247340 CA449030 BE410238 BM917818 CA437786 BU167502 BI093883 BQ691877 
    CR611017 BM791949 CB120654 BQ642471 BQ219218 BM562614 BE294355 CF131077 
    BQ643461 BG774190 BQ062091 AA375299 BM554356 BI062202 CD369752 BM803140 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ABCF2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCTGGACTCG
    ABCF2 Expression
    About this image


    ABCF2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 11) fully expand
     
     Brain (Nervous System)    fully expand to see all 10 entries
             Thalamus
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Telencephalon
     
     Lung (Respiratory System)    fully expand to see all 2 entries
             Stem Bronchi
     
     Thymus (Hematopoietic System)
             Thymus
     
     Bone (Muscoskeletal System)
             Bone Marrow
    ABCF2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ABCF2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.654958
        Custom PCR Arrays for ABCF2
    Primer
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    OriGene qPCR primer pairs and template standards for ABCF2
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    QuantiFast Probe-based Assays in human, mouse, rat ABCF2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ABCF2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ABCF2 gene from Selected species (see all 27)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Abcf21 , 5 ATP-binding cassette, sub-family F (GCN20), member more1, 5 91.87(n)1
    99.04(a)1
      5 (11.93 cM)5
    274071  NM_013853.21  NP_038881.11 
     245653415 
    chicken
    (Gallus gallus)
    Aves ABCF21 ATP-binding cassette, sub-family F (GCN20), member more 80.74(n)
    95.18(a)
      426038  NM_001006562.1  NP_001006562.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia abcf2-prov2 ATP-binding cassette, sub-family F (GCN20), member more 80.31(n)    BC046677.1 
    zebrafish
    (Danio rerio)
    Actinopterygii abcf22 ATP-binding cassette, sub-family F (GCN20), member more 78.72(n)   336770  BC047181.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG92811 , 3 ATP-binding cassette (ABC) transporter3
    CG92811
    69(a)3
    65.39(n)1
    70.12(a)1
      13E83
    325081  NM_167458.21  NP_727881.11 
    worm
    (Caenorhabditis elegans)
    Secernentea abcf-21 abcf-2 61.83(n)
    65.59(a)
      176771  NM_067378.4  NP_499779.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ARB1(YER036C)4
    ARB11
    ATPase of the ATP-binding cassette (ABC) family involved more4
    ARB11
    52.89(n)1
    52.89(a)1
      5(225199-223367)4
    8567581, 4  NP_010953.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons GCN11 GCN1 61.42(n)
    64.01(a)
      836200  NM_125472.2  NP_200887.1 
    rice
    (Oryza sativa)
    Liliopsida AK069041.12   -- 73.76(n)    AK069041.1 


    ENSEMBL Gene Tree for ABCF2 (if available)
    TreeFam Gene Tree for ABCF2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ABCF2 gene
    Selected SIMAP similar genes for ABCF2 using alignment to 5 protein entries:     ABCF2_HUMAN (see all proteins) (see all similar genes):
    HIST1H2BA    HIST1H2BB    HIST1H2BD    HIST1H2BE    HIST1H2BF    HIST1H2BG
    HIST1H2BH    HIST1H2BI    HIST1H2BJ    HIST1H2BK    HIST1H2BL    HIST1H2BM
    HIST1H2BN    HIST1H2BO    HIST2H2BE    HIST2H2BF    HIST3H2BB    HIST1H2BC

    Find genes that share paralogs with ABCF2           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for ABCF2
    PGOHUM00000238094 PGOHUM00000233410


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ABCF2 (see all 576)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1493660171,2
    --150904583(+) CCTGTC/TGTACA 1 -- ds50010--------
    rs737271181,2
    C,F--150904603(+) GACAGT/CTGGTG 1 -- ds50012Minor allele frequency- C:0.02WA 120
    rs1447272531,2
    --150904622(+) CATCGC/TGAAGA 1 -- ds50010--------
    rs1486761331,2
    C--150904644(+) AGAGGA/GCCATA 1 -- ds50010--------
    rs77895931,2
    C,F,A,H--150904783(+) CTCACG/AGGATA 1 -- ds500120Minor allele frequency- A:0.09NS EA NA WA CSA 1742
    rs1904218611,2
    --150904844(+) GGTAGC/TCTCGA 1 -- ds50010--------
    rs1820480791,2
    --150904931(+) AGTTCA/GCCCTT 1 -- ut310--------
    rs1474393691,2
    --150904950(+) TCAGGC/TCCTGG 1 -- ut310--------
    rs790652921,2
    C,F--150905101(+) AGCCGG/CGCAGC 1 -- ut312Minor allele frequency- C:0.10CSA WA 120
    rs27924411,2
    C,F,O,H--150905167(+) GCCTTG/AGCAGA 2 /P /L mis116Minor allele frequency- A:0.01NA NS EA EU 7515

    HapMap Linkage Disequilibrium report for ABCF2 (150904923 - 150924317 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for ABCF2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2735396CNV Deletion23290073
    nsv435860CNV Deletion17901297
    nsv889487CNV Loss21882294
    nsv831188CNV Loss17160897
    nsv889476CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    1 Copy Number PCR Panel containing ABCF2:
    Ovarian Cancer
    Search QIAGEN SeqTarget long-range PCR primers for resequencing ABCF2
    DNA2.0 Custom Variant and Variant Library Synthesis for ABCF2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 612510    OMIM disorders: --

    1 disease for ABCF2:    
    About MalaCards
    cystic fibrosis

    1 disease from the University of Copenhagen DISEASES database for ABCF2:
    Clear cell adenocarcinoma

    Find genes that share disorders with ABCF2           About GenesLikeMe

    2 Novoseek inferred disease relationships for ABCF2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cystic fibrosis 47.6 1 9162024 (1)
    breast cancer 29.6 2 12145683 (1), 15060738 (1)

    Genetic Association Database (GAD): ABCF2
    Human Genome Epidemiology (HuGE) Navigator: ABCF2 (2 documents)

    Export disorders for ABCF2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ABCF2 gene, integrated from 10 sources (see all 61):
    (articles sorted by number of sources associating them with ABCF2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    2. Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects. (PubMed id 19343046)1, 4 Saito A....Kamatani N. (J. Hum. Genet. 2009)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (Nature 2003)
    5. Characterization of 16 novel human genes showing high similarity to yeast sequences. (PubMed id 11124703)1, 2 Stanchi F.... Valle G. (Yeast 2001)
    6. cDNA cloning by amplification of circularized first strand cDNAs reveals non-IRE-regulated iron-responsive mRNAs. (PubMed id 10944468)1, 2 Ye Z. and Connor J.R. (Biochem. Biophys. Res. Commun. 2000)
    7. Characterization of the human ABC superfamily: isolation and mapping of 21 new genes using the expressed sequence tags database. (PubMed id 8894702)1, 3 Allikmets R....Dean M. (Hum. Mol. Genet. 1996)
    8. A Proteomics Strategy for the Identification of FAT10-Modified Sites by Mass Spectrometry. (PubMed id 23862649)1 Leng L....Wang J. (J. Proteome Res. 2014)
    9. Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. (PubMed id 23382691)1 Lauc G....Rudan I. (PLoS Genet. 2013)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 10061 HGNC: 71 AceView: ABCF2 Ensembl:ENSG00000033050 euGenes: HUgn10061
    ECgene: ABCF2 H-InvDB: ABCF2

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ABCF2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ABCF2 Genetics and Cytogenetics in Oncology and Haematology
    ABCMdbhttp://abcmutations.hegelab.org/proteinDetails?uniprot_id=Q9UG63

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ABCF2 gene:
    Search GeneIP for patents involving ABCF2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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