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Aliases for ABCF2 Gene

Aliases for ABCF2 Gene

  • ATP-Binding Cassette, Sub-Family F (GCN20), Member 2 2 3
  • Iron-Inhibited ABC Transporter 2 3 4
  • HUSSY18 3 6
  • ATP-Binding Cassette Sub-Family F Member 2 3
  • ABC-Type Transport Protein 3
  • EC 3.6.3.17 63
  • EST133090 3
  • HUSSY-18 3
  • EC 3.6.3 63
  • ABC28 3

External Ids for ABCF2 Gene

Previous GeneCards Identifiers for ABCF2 Gene

  • GC07M149151
  • GC07M150219
  • GC07M150296
  • GC07M150342
  • GC07M150535
  • GC07M150904
  • GC07M144715

Summaries for ABCF2 Gene

Entrez Gene Summary for ABCF2 Gene

  • This gene encodes a member of the ATP-binding cassette (ABC) transporter superfamily. ATP-binding casette proteins transport various molecules across extra- and intracellular membranes. Alterations in this gene may be involved in cancer progression. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 3 and 7. [provided by RefSeq, Jul 2013]

GeneCards Summary for ABCF2 Gene

ABCF2 (ATP-Binding Cassette, Sub-Family F (GCN20), Member 2) is a Protein Coding gene. Diseases associated with ABCF2 include cystic fibrosis. GO annotations related to this gene include transporter activity and ATPase activity.

Gene Wiki entry for ABCF2 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ABCF2 Gene

Genomics for ABCF2 Gene

Regulatory Elements for ABCF2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ABCF2 Gene

Start:
151,207,830 bp from pter
End:
151,227,374 bp from pter
Size:
19,545 bases
Orientation:
Minus strand

Genomic View for ABCF2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ABCF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ABCF2 Gene

Proteins for ABCF2 Gene

  • Protein details for ABCF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UG63-ABCF2_HUMAN
    Recommended name:
    ATP-binding cassette sub-family F member 2
    Protein Accession:
    Q9UG63
    Secondary Accessions:
    • O60864
    • Q75MJ0
    • Q75MJ1
    • Q96TE8

    Protein attributes for ABCF2 Gene

    Size:
    623 amino acids
    Molecular mass:
    71290 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ABCF2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ABCF2 Gene

Proteomics data for ABCF2 Gene at MOPED

Selected DME Specific Peptides for ABCF2 Gene

Post-translational modifications for ABCF2 Gene

  • Ubiquitination at Lys315, Lys339, Lys365, Lys436, Lys508, Lys602, and Lys618
  • Modification sites at PhosphoSitePlus

Other Protein References for ABCF2 Gene

Antibody Products

Domains for ABCF2 Gene

Gene Families for ABCF2 Gene

HGNC:
  • ABCF :ATP binding cassette transporters / subfamily F

Protein Domains for ABCF2 Gene

Suggested Antigen Peptide Sequences for ABCF2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UG63

UniProtKB/Swiss-Prot:

ABCF2_HUMAN :
  • Q9UG63
Domain:
  • Contains 2 ABC transporter domains.
Family:
  • Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily.
genes like me logo Genes that share domains with ABCF2: view

Function for ABCF2 Gene

Molecular function for ABCF2 Gene

GENATLAS Biochemistry: ATP-binding cassette superfamily,subfamily F (GCN20),member 2

Enzyme Numbers (IUBMB) for ABCF2 Gene

Gene Ontology (GO) - Molecular Function for ABCF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity TAS 9878413
GO:0005524 ATP binding IEA --
GO:0016887 ATPase activity IEA --
genes like me logo Genes that share ontologies with ABCF2: view

Phenotypes for ABCF2 Gene

GenomeRNAi human phenotypes for ABCF2:
genes like me logo Genes that share phenotypes with ABCF2: view

Animal Model Products

CRISPR Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for ABCF2 Gene

Localization for ABCF2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ABCF2 Gene COMPARTMENTS Subcellular localization image for ABCF2 gene
Compartment Confidence
mitochondrion 4
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for ABCF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion --
GO:0005740 mitochondrial envelope TAS 9878413
GO:0016020 membrane IDA 19946888
GO:0043190 ATP-binding cassette (ABC) transporter complex TAS 9878413
genes like me logo Genes that share ontologies with ABCF2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ABCF2 Gene

Pathways for ABCF2 Gene

SuperPathways for ABCF2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ABCF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006200 obsolete ATP catabolic process --
GO:0006810 transport TAS 9878413
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with ABCF2: view

No data available for Pathways by source for ABCF2 Gene

Compounds for ABCF2 Gene

(1) Novoseek inferred chemical compound relationships for ABCF2 Gene

Compound -log(P) Hits PubMed IDs
mitoxantrone 57.9 1
genes like me logo Genes that share compounds with ABCF2: view

Transcripts for ABCF2 Gene

Unigene Clusters for ABCF2 Gene

ATP-binding cassette, sub-family F (GCN20), member 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ABCF2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ABCF2 Gene

No ASD Table

Relevant External Links for ABCF2 Gene

GeneLoc Exon Structure for
ABCF2
ECgene alternative splicing isoforms for
ABCF2

Expression for ABCF2 Gene

mRNA expression in normal human tissues for ABCF2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ABCF2 Gene

SOURCE GeneReport for Unigene cluster for ABCF2 Gene Hs.654958

genes like me logo Genes that share expressions with ABCF2: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ABCF2 Gene

Orthologs for ABCF2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ABCF2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ABCF2 35
  • 99.74 (n)
  • 99.84 (a)
ABCF2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ABCF2 35
  • 93.15 (n)
  • 98.07 (a)
ABCF2 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ABCF2 35
  • 94.01 (n)
  • 98.26 (a)
ABCF2 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Abcf2 35
  • 91.87 (n)
  • 99.04 (a)
Abcf2 16
Abcf2 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ABCF2 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ABCF2 36
  • 96 (a)
OneToOne
chicken
(Gallus gallus)
Aves ABCF2 35
  • 80.74 (n)
  • 95.18 (a)
ABCF2 36
  • 95 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia abcf2-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.6657 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10004 35
zebrafish
(Danio rerio)
Actinopterygii abcf2 35
abcf2a 35
  • 76.53 (n)
  • 88.26 (a)
abcf2a 36
  • 88 (a)
OneToMany
BX322787.1 36
  • 87 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002693 35
  • 67.71 (n)
  • 71.23 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG9281 35
  • 65.39 (n)
  • 70.12 (a)
CG9281 36
  • 69 (a)
OneToOne
CG9281 37
  • 69 (a)
worm
(Caenorhabditis elegans)
Secernentea abcf-2 35
  • 61.83 (n)
  • 65.59 (a)
abcf-2 36
  • 61 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR232C 35
  • 55.12 (n)
  • 53.18 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ARB1 35
  • 52.89 (n)
  • 52.89 (a)
ARB1 36
  • 50 (a)
OneToOne
ARB1 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A01452g 35
  • 54.81 (n)
  • 54.19 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.1549 35
soybean
(Glycine max)
eudicotyledons Gma.7643 35
thale cress
(Arabidopsis thaliana)
eudicotyledons GCN1 35
  • 61.42 (n)
  • 64.01 (a)
corn
(Zea mays)
Liliopsida Zm.2713 35
rice
(Oryza sativa)
Liliopsida Os09g0572400 35
  • 64.68 (n)
  • 69.4 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.28668 35
bread mold
(Neurospora crassa)
Ascomycetes NCU08920 35
  • 56.7 (n)
  • 51.65 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3407 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5307 36
  • 60 (a)
OneToOne
Species with no ortholog for ABCF2:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for ABCF2 Gene

ENSEMBL:
Gene Tree for ABCF2 (if available)
TreeFam:
Gene Tree for ABCF2 (if available)

Paralogs for ABCF2 Gene

Pseudogenes.org Pseudogenes for ABCF2 Gene

genes like me logo Genes that share paralogs with ABCF2: view

No data available for Paralogs for ABCF2 Gene

Variants for ABCF2 Gene

Sequence variations from dbSNP and Humsavar for ABCF2 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs2414 -- 151,213,556(+) CAGGT(C/T)TAAAA intron-variant, utr-variant-3-prime
rs2415 -- 151,213,549(+) TGTCA(C/T)GCAGG intron-variant, utr-variant-3-prime
rs736053 -- 151,217,425(+) ATCAA(C/T)ATTAA intron-variant
rs897917 -- 151,212,531(+) gtctc(C/G)gtctg intron-variant, utr-variant-3-prime
rs1056717 -- 151,214,069(-) AAGAG(A/G/T)ACCCA synonymous-codon, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for ABCF2 Gene

Variant ID Type Subtype PubMed ID
nsv889476 CNV Loss 21882294
nsv831188 CNV Loss 17160897
esv2735396 CNV Deletion 23290073
nsv889487 CNV Loss 21882294
nsv435860 CNV Deletion 17901297

Relevant External Links for ABCF2 Gene

HapMap Linkage Disequilibrium report
ABCF2

PCR Panel Products

  • Copy Number PCR Panels: for ABCF2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ABCF2 Gene

Disorders for ABCF2 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for ABCF2 Gene including...

Search for ABCF2 Gene in MalaCards »

(1) University of Copenhagen DISEASES for ABCF2 Gene

(2) Novoseek inferred disease relationships for ABCF2 Gene

Disease -log(P) Hits PubMed IDs
cystic fibrosis 47.6 1
breast cancer 29.6 2

Relevant External Links for ABCF2

Genetic Association Database (GAD)
ABCF2
Human Genome Epidemiology (HuGE) Navigator
ABCF2
genes like me logo Genes that share disorders with ABCF2: view

No data available for UniProtKB/Swiss-Prot for ABCF2 Gene

Publications for ABCF2 Gene

  1. Characterization of the human ABC superfamily: isolation and mapping of 21 new genes using the expressed sequence tags database. (PMID: 8894702) Allikmets R. … Dean M. (Hum. Mol. Genet. 1996) 2 3
  2. cDNA cloning by amplification of circularized first strand cDNAs reveals non-IRE-regulated iron-responsive mRNAs. (PMID: 10944468) Ye Z. … Connor J.R. (Biochem. Biophys. Res. Commun. 2000) 3 4
  3. Characterization of 16 novel human genes showing high similarity to yeast sequences. (PMID: 11124703) Stanchi F. … Valle G. (Yeast 2001) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48

Products for ABCF2 Gene

Sources for ABCF2 Gene

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