Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



ABCF1 Gene

protein-coding   GIFtS: 60
GCID: GC06P030539

ATP-Binding Cassette, Sub-Family F (GCN20), Member 1


(Previous symbol: ABC50)
  Search for ABCF1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
ATP-Binding Cassette, Sub-Family F (GCN20), Member 11 2     ATP-Binding Cassette Sub-Family F Member 12
ABC501 2 3 5     TNFalpha-Inducible ATP-Binding Protein2
TNF-Alpha-Stimulated ABC Protein2 3     ATP-Binding Cassette 503
ABC272     EC 2.7.7.68
ATP-Binding Cassette 50 (TNF-Alpha Stimulated)2     EC 3.6.3.178

External Ids:    HGNC: 701   Entrez Gene: 232   Ensembl: ENSG000002045747   OMIM: 6034295   UniProtKB: Q8NE713   

Export aliases for ABCF1 gene to outside databases

Previous GC identifers: GC06P030594 GC06P030309 GC06P030645 GC06P030647 GC06P030339


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for ABCF1 Gene:
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC
proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven
distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the GCN20
subfamily. Unlike other members of the superfamily, this protein lacks the transmembrane domains which are
characteristic of most ABC transporters. This protein may be regulated by tumor necrosis factor-alpha and play a
role in enhancement of protein synthesis and the inflammation process. (provided by RefSeq, Jul 2008)

GeneCards Summary for ABCF1 Gene:
ABCF1 (ATP-binding cassette, sub-family F (GCN20), member 1) is a protein-coding gene. GO annotations related to this gene include translation factor activity, nucleic acid binding and ATPase activity. An important paralog of this gene is ABCF3.

UniProtKB/Swiss-Prot: ABCF1_HUMAN, Q8NE71
Function: Isoform 2 is required for efficient Cap- and IRES-mediated mRNA translation initiation. Isoform 2 is not
involved in the ribosome biogenesis

Gene Wiki entry for ABCF1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NC_018917.2  NT_007592.16  NT_113891.3  NT_167245.2  NT_167246.2  NT_167247.2  NT_167248.2  
NT_167249.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ABCF1 gene promoter:
         AREB6   IRF-2   p53   SREBP-1a   Pax-5   SREBP-1c   SREBP-1b   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): ABCF1 promoter sequence
   Search Chromatin IP Primers for ABCF1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ABCF1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.33   Ensembl cytogenetic band:  6p21.33   HGNC cytogenetic band: 6p21.33

ABCF1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ABCF1 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P030539:  view genomic region     (about GC identifiers)

Start:
30,539,153 bp from pter      End:
30,564,956 bp from pter
Size:
25,804 bases      Orientation:
plus strand

6 alternative locations:
Chr6+,NT_167245 1,832,805-1,852,944      Chr6+,NT_167247 1,921,024-1,941,163      Chr6+,NT_167249 1,871,448-1,891,586     
Chr6+,NT_113891.2 2,051,221-2,071,356      Chr6+,NT_167246 1,887,242-1,907,381      Chr6+,NT_167248 1,832,076-1,852,211     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: ABCF1_HUMAN, Q8NE71 (See protein sequence)
Recommended Name: ATP-binding cassette sub-family F member 1  
Size: 845 amino acids; 95926 Da
Subunit: Isoform 2 interacts (via N-terminus) with EIF2S1; the interaction is independent of its phosphorylated
status. Isoform 2 associates (via both ABC transporter domains) with the ribosomes
Secondary accessions: A2BF75 O14897 Q69YP6
Alternative splicing: 2 isoforms:  Q8NE71-1   Q8NE71-2   

Explore the universe of human proteins at neXtProt for ABCF1: NX_Q8NE71

Explore proteomics data for ABCF1 at MOPED

Post-translational modifications: 

  • Isoform 2 is phosphorylated at phosphoserine and phosphothreonine. Isoform 2 phosphorylation on Ser-109 and
    Ser-140 by CK2; inhibits association of EIF2 with ribosomes1
  • Ubiquitination2 at Lys39, Lys451, Lys573, Lys582, Lys689
  • Modification sites at PhosphoSitePlus
  • 3 DME Specific Peptides for ABCF1 (Q8NE71)
     LMLDEPT  LILDEPT  KRLKLLE 


    See ABCF1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001020262.1  NP_001081.1  

    ENSEMBL proteins: 
     ENSP00000313603   ENSP00000365728   ENSP00000405512   ENSP00000440893   ENSP00000445100  
     ENSP00000379772  

    ABCF1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for ABCF1
    OriGene Custom MassSpec
    OriGene Custom Protein Services for ABCF1
    GenScript Custom Purified and Recombinant Proteins Services for ABCF1
    Novus Biologicals ABCF1 Protein
    Novus Biologicals ABCF1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ABCF1

     
    Search eBioscience for Proteins for ABCF1 

    ABCF1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for ABCF1
    OriGene Custom Antibody Services for ABCF1
    Novus Biologicals ABCF1 Antibodies
    Abcam antibodies for ABCF1
    Cloud-Clone Corp. Antibodies for ABCF1
    ThermoFisher Antibody for ABCF1
    LSBio Antibodies in human, mouse, rat for ABCF1

    ABCF1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ABCF1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ABCF1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ABCF1
    Cloud-Clone Corp. CLIAs for ABCF1
    Search eBioscience for ELISAs for ABCF1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    ABCF: ATP binding cassette transporters / subfamily F

    4 InterPro protein domains:
     IPR003439 ABC_transporter-like
     IPR027417 P-loop_NTPase
     IPR003593 AAA+_ATPase
     IPR017871 ABC_transporter_CS

    Graphical View of Domain Structure for InterPro Entry Q8NE71

    ProtoNet protein and cluster: Q8NE71

    UniProtKB/Swiss-Prot: ABCF1_HUMAN, Q8NE71
    Similarity: Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily
    Similarity: Contains 2 ABC transporter domains


    Find genes that share domains with ABCF1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ABCF1_HUMAN, Q8NE71
    Function: Isoform 2 is required for efficient Cap- and IRES-mediated mRNA translation initiation. Isoform 2 is not
    involved in the ribosome biogenesis
    Induction: By TNF in cultured synoviocytes

         Genatlas biochemistry entry for ABCF1:
    ATP binding cassette superfamily,subfamily F (GCN20) member 1,widely expressed,putative ribosomal protein,involved
    in translation of mRNA,present in synoviocytes after TNFA induction,potentially involved in inflammatory process

         Enzyme Numbers (IUBMB): EC 2.7.7.62 EC 3.6.3.172

         Gene Ontology (GO): Selected molecular function terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding ----
    GO:0005515protein binding IPI17894550
    GO:0005524ATP binding IEA--
    GO:0008135translation factor activity, nucleic acid binding TAS9790762
    GO:0008494translation activator activity IDA19570978
         
    Find genes that share ontologies with ABCF1           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ABCF1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ABCF1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ABCF1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ABCF1

    miRNA
    Products:
        
    miRTarBase miRNAs that target ABCF1:
    hsa-mir-23b-3p (MIRT046277), hsa-mir-484 (MIRT041991), hsa-mir-26b-5p (MIRT028745), hsa-mir-98-5p (MIRT027413), hsa-mir-16-5p (MIRT031407), hsa-let-7b-5p (MIRT052203), hsa-mir-615-3p (MIRT040193), hsa-mir-183-5p (MIRT025000)

    Block miRNA regulation of human, mouse, rat ABCF1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ABCF1 (see all 10):
    hsa-miR-4291 hsa-miR-15a hsa-miR-497 hsa-miR-103a hsa-miR-424 hsa-miR-593* hsa-miR-16 hsa-miR-195
    SwitchGear 3'UTR luciferase reporter plasmidABCF1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ABCF1
    Predesigned siRNA for gene silencing in human, mouse, rat ABCF1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ABCF1

    Clone
    Products:
         
    OriGene clones in human, mouse for ABCF1 (see all 11)
    OriGene ORF clones in mouse, rat for ABCF1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ABCF1 (NM_001090)
    Sino Biological Human cDNA Clone for ABCF1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ABCF1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ABCF1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ABCF1
    Browse ESI BIO Cell Lines and PureStem Progenitors for ABCF1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ABCF1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    ABCF1_HUMAN, Q8NE71: Isoform 2: Cytoplasm. Nucleus, nucleoplasm. Nucleus envelope
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005635nuclear envelope IEA--
    GO:0005654nucleoplasm IEA--
    GO:0005737cytoplasm IDA--
    GO:0005840ribosome IEA--
    GO:0042788polysomal ribosome IDA19570978

    Find genes that share ontologies with ABCF1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus




        Pathway & Disease-focused RT2 Profiler PCR Array including ABCF1: 
              Drug Transporters in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for ABCF1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ABCF1 (Q8NE712, 3 ENSP000003136034) via UniProtKB, MINT, STRING, and/or I2D (see all 806)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCT6AP402272, ENSP000002756034MINT-7945693 MINT-7947479 STRING: ENSP00000275603
    ETF1P624952, ENSP000003537414MINT-7945693 MINT-7947479 STRING: ENSP00000353741
    GCN1L1Q926162, ENSP000003006484MINT-7945693 MINT-7947479 STRING: ENSP00000300648
    EIF6P565373, ENSP000003635594I2D: score=3 STRING: ENSP00000363559
    ABCF3Q9NUQ82MINT-7945693 MINT-7947479
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006412translation TAS9790762
    GO:0006413translational initiation IMP19570978
    GO:0006954inflammatory response TAS9790762
    GO:0042254NOT ribosome biogenesis IDA19570978
    GO:0045727positive regulation of translation IDA19570978

    Find genes that share ontologies with ABCF1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ABCF1

    1 HMDB Compound for ABCF1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for ABCF1 gene (2 alternative transcripts): 
    NM_001025091.1  NM_001090.2  

    Unigene Cluster for ABCF1:

    ATP-binding cassette, sub-family F (GCN20), member 1
    Hs.655285  [show with all ESTs]
    Unigene Representative Sequence: NM_001025091
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000326195(uc003nqk.2 uc003nql.3 uc003nqm.3) ENST00000376545
    ENST00000441867 ENST00000468958 ENST00000542772 ENST00000475993 ENST00000479542
    ENST00000396515
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ABCF1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ABCF1 (see all 10):
    hsa-miR-4291 hsa-miR-15a hsa-miR-497 hsa-miR-103a hsa-miR-424 hsa-miR-593* hsa-miR-16 hsa-miR-195
    SwitchGear 3'UTR luciferase reporter plasmidABCF1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ABCF1
    Predesigned siRNA for gene silencing in human, mouse, rat ABCF1
    Clone
    Products:
         
    OriGene clones in human, mouse for ABCF1 (see all 11)
    OriGene ORF clones in mouse, rat for ABCF1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ABCF1 (NM_001090)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ABCF1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ABCF1
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for ABCF1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ABCF1
      QuantiTect SYBR Green Assays in human, mouse, rat ABCF1
      QuantiFast Probe-based Assays in human, mouse, rat ABCF1

    Additional mRNA sequence: 

    AB209564.1 AF027302.1 AF075071.1 AK298061.1 AK307551.1 AL832430.1 BC016772.1 BC034488.2 
    BC112923.1 U66677.1 

    18 DOTS entries:

    DT.100815058  DT.101984925  DT.217889  DT.92442036  DT.100815063  DT.95108905  DT.121360162  DT.97769090 
    DT.100815055  DT.95258527  DT.91777805  DT.100815060  DT.121360120  DT.121360366  DT.95189966  DT.97855263 
    DT.40190068  DT.95189965 

    Selected AceView cDNA sequences (see all 391):

    BQ060962 BM696808 AI684204 BE785493 BQ073631 AI803061 CK823449 BQ058520 
    BQ962497 BQ940958 BF064113 CR591008 BE698504 F35014 BU187212 F07368 
    CA455305 BM918251 BQ057882 AA085751 AI160775 BQ951527 AI167633 BM687901 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    ABCF1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGGTGGAGT
    ABCF1 Expression
    About this image

    ABCF1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ABCF1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.655285

    UniProtKB/Swiss-Prot: ABCF1_HUMAN, Q8NE71
    Tissue specificity: Ubiquitous

        Pathway & Disease-focused RT2 Profiler PCR Array including ABCF1: 
              Drug Transporters in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for ABCF1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ABCF1
    QuantiTect SYBR Green Assays in human, mouse, rat ABCF1
    QuantiFast Probe-based Assays in human, mouse, rat ABCF1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ABCF1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ABCF1 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Abcf11 , 5 ATP-binding cassette, sub-family F (GCN20), member more1, 5 86.45(n)1
    92.02(a)1
      17 (18.80 cM)5
    2247421  NM_013854.11  NP_038882.11 
     359568195 
    lizard
    (Anolis carolinensis)
    Reptilia ABCF16
    ATP-binding cassette, sub-family F (GCN20), member...
    75(a)
    1 ↔ 1
    2(191956777-192012930)
    African clawed frog
    (Xenopus laevis)
    Amphibia BU914504.12   -- 76.69(n)    BU914504.1 
    zebrafish
    (Danio rerio)
    Actinopterygii CK236499.12   -- 76.56(n)    CK236499.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG17031 , 3 ATP-binding cassette (ABC) transporter3
    CG17031
    65(a)3
    63.18(n)1
    64.55(a)1
      10D13
    321121  NM_132508.31  NP_572736.11 
    worm
    (Caenorhabditis elegans)
    Secernentea F18E2.23
    abcf-11
    ABC transpoter3
    abcf-11
    61(a)3
    58.84(n)1
    62.37(a)1
      V(12763786-12765958)3
    1797481  NM_073791.51  NP_506192.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes (YDR061W)4 Protein with similarity to ATP-binding cassette (ABC) more   --   4(574164-575783) 851633  NP_010346.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons GCN41 GCN4 52.79(n)
    50(a)
      824619  NM_115311.3  NP_567001.1 
    rice
    (Oryza sativa)
    Liliopsida Os03g04415001 Os03g0441500 55.93(n)
    52.17(a)
      4333216  NM_001056996.1  NP_001050461.1 


    ENSEMBL Gene Tree for ABCF1 (if available)
    TreeFam Gene Tree for ABCF1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for ABCF1 gene
    ABCF32  
    2 SIMAP similar genes for ABCF1 using alignment to 8 protein entries:     ABCF1_HUMAN (see all proteins):
    ABCF3    ABCF2

    Find genes that share paralogs with ABCF1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for ABCF1 (see all 428)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs31302421,2
    C,F,H--30537339(+) CACTCA/GTGCCA 2 -- us2k124Minor allele frequency- G:0.25NS EA NA WA CSA 2352
    rs759298141,2
    C,F--30537345(+) TGCCAC/GTCCAG 2 -- us2k11Minor allele frequency- G:0.05EA 120
    rs1908263691,2
    --30537391(+) TGTCCA/GAACAC 2 -- us2k10--------
    rs774165961,2
    C--30537489(+) AATGAT/CTTGCT 2 -- us2k13Minor allele frequency- C:0.08CSA WA EA 240
    rs1148476971,2
    C,F--30537516(+) GAGGCC/TTCATT 2 -- us2k11Minor allele frequency- T:0.04WA 118
    rs31326131,2
    C,F,O,A,H--30537606(-) gATTAC/GGTTTC 2 -- us2k120Minor allele frequency- N:0.00EA NS NA WA CSA 950
    rs678927101,2
    C--30537612(+) TAATC-/AGAGATC 2 -- us2k10--------
    rs603877971,2
    C--30537615(+) TCAGA-/GATCTTT 2 -- us2k10--------
    rs31302431,2
    C,F,A,H--30537853(+) acaggA/Ctttag 2 -- us2k124Minor allele frequency- C:0.29NS EA NA WA CSA 2352
    rs1394270971,2
    --30537999(+) GAATCA/TTCATT 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for ABCF1 (30539153 - 30564956 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for ABCF1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2670269CNV Deletion23128226
    esv2731791CNV Deletion23290073
    nsv5244CNV Loss18451855
    nsv830626CNV Loss17160897
    nsv884091CNV Loss21882294
    nsv884086CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ABCF1
    DNA2.0 Custom Variant and Variant Library Synthesis for ABCF1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 603429    OMIM disorders: --


    Find genes that share disorders with ABCF1           About GenesLikeMe

    Genetic Association Database (GAD): ABCF1
    Human Genome Epidemiology (HuGE) Navigator: ABCF1 (7 documents)

    Export disorders for ABCF1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for ABCF1 gene, integrated from 10 sources (see all 51):
    (articles sorted by number of sources associating them with ABCF1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. ABC50, a novel human ATP-binding cassette protein found in tumor necrosis factor-alpha-stimulated synoviocytes. (PubMed id 9790762)1, 2, 3 Richard M.... Beaulieu A.D. (Genomics 1998)
    2. The N-terminal region of ABC50 interacts with eukaryotic initiation factor eIF2 and is a target for regulatory phosphorylation by CK2. (PubMed id 17894550)1, 2, 9 Paytubi S.... Proud C.G. (Biochem. J. 2008)
    3. Identification of independent risk loci for Graves' disease within the MHC in the Japanese population. (PubMed id 21900946)1, 4 Nakabayashi K....Shirasawa S. (J. Hum. Genet. 2011)
    4. HLA-E gene polymorphism associates with ankylosing spondylitis in Sardinia. (PubMed id 19912639)1, 4 Paladini F....Sorrentino R. (amp 2009)
    5. Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects. (PubMed id 19343046)1, 4 Saito A....Kamatani N. (J. Hum. Genet. 2009)
    6. ABC50 promotes translation initiation in mammalian cells. (PubMed id 19570978)1, 2 Paytubi S.... Proud C.G. (J. Biol. Chem. 2009)
    7. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PubMed id 19851445)1, 4 Barcellos L.F....Criswell L.A. (PLoS Genet. 2009)
    8. Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry. (PubMed id 17370265)1, 2 Denis N.J.... Figeys D. (Proteomics 2007)
    9. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (Nat. Biotechnol. 2006)
    10. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 23 HGNC: 70 AceView: ABCF1 Ensembl:ENSG00000204574 euGenes: HUgn23
    ECgene: ABCF1 H-InvDB: ABCF1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for ABCF1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ABCF1 Genetics and Cytogenetics in Oncology and Haematology
    ABCMdbhttp://abcmutations.hegelab.org/proteinDetails?uniprot_id=Q8NE71

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for ABCF1 gene:
    Search GeneIP for patents involving ABCF1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for ABCF1   OriGene RNAi products in human, mouse, rat for ABCF1  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for ABCF1  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for ABCF1  
     OriGene qSTAR qPCR primer pairs in human, mouse for ABCF1   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for ABCF1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ABCF1   OriGene Custom Protein Services for ABCF1  

     
     
     Block miRNA regulation of human, mouse, rat ABCF1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing ABCF1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ABCF1 Predesigned siRNA for gene silencing in human, mouse, rat ABCF1
     QuantiFast Probe-based Assays in human, mouse, rat ABCF1 QuantiTect SYBR Green Assays in human, mouse, rat ABCF1
     PCR Arrays including human, mouse, rat ABCF1 Search Chromatin IP Primers for ABCF1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ABCF1  GeneGlobe Interaction Network for ABCF1
     Regulatory tfbs in ABCF1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for ABCF1 GenScript cDNA clones with any tag delivered in your preferred vector for ABCF1
     GenScript Custom Assay Services for ABCF1 GenScript Custom overexpressing Cell Line Services for ABCF1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for ABCF1
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for ABCF1
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     ABCF1 antibodies
     ABCF1 proteins
     ABCF1 lysates
     Antibodies for ABCF1
     See all of Abcam's Antibodies, Kits and Proteins for ABCF1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for ABCF1
     Antibodies for ABCF1
     ELISAs for ABCF1
     CLIAs for ABCF1



     Browse ESI BIO Cell Lines and PureStem Progenitors for ABCF1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ABCF1
     SwitchGear 3'UTR luciferase reporter plasmids for ABCF1
     SwitchGear Promoter luciferase reporter plasmids for ABCF1
     ThermoFisher Antibody for ABCF1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ABCF1
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ABCF1
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ABCF1
     LSBio Antibodies in human, mouse, rat for ABCF1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for ABCF1
      Search eBioscience for proteins for ABCF1
      Search eBioscience for elisas for ABCF1
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      ABCF1 gene at Home site.
    Version: 3.12.212 17 Sep 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4