Aliases for ABCF1 Gene
External Ids for ABCF1 Gene
Previous HGNC Symbols for ABCF1 Gene
Previous GeneCards Identifiers for ABCF1 Gene
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the GCN20 subfamily. Unlike other members of the superfamily, this protein lacks the transmembrane domains which are characteristic of most ABC transporters. This protein may be regulated by tumor necrosis factor-alpha and play a role in enhancement of protein synthesis and the inflammation process. [provided by RefSeq, Jul 2008]
GeneCards Summary for ABCF1 Gene
ABCF1 (ATP Binding Cassette Subfamily F Member 1) is a Protein Coding gene. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and CDK-mediated phosphorylation and removal of Cdc6. GO annotations related to this gene include poly(A) RNA binding and ribosome binding. An important paralog of this gene is ABCF3.
UniProtKB/Swiss-Prot for ABCF1 Gene
Isoform 2 is required for efficient Cap- and IRES-mediated mRNA translation initiation. Isoform 2 is not involved in the ribosome biogenesis.