Aliases for ABCE1 Gene
External Ids for ABCE1 Gene
Previous HGNC Symbols for ABCE1 Gene
Previous GeneCards Identifiers for ABCE1 Gene
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the OABP subfamily. Alternatively referred to as the RNase L inhibitor, this protein functions to block the activity of ribonuclease L. Activation of ribonuclease L leads to inhibition of protein synthesis in the 2-5A/RNase L system, the central pathway for viral interferon action. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for ABCE1 Gene
ABCE1 (ATP-Binding Cassette, Sub-Family E (OABP), Member 1) is a Protein Coding gene. Diseases associated with ABCE1 include hiv-1. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and ABC-family proteins mediated transport. GO annotations related to this gene include ATPase activity and ribonuclease inhibitor activity.
UniProtKB/Swiss-Prot for ABCE1 Gene
Antagonizes the binding of 2-5A (5-phosphorylated 2,5-linked oligoadenylates) by RNase L through direct interaction with RNase L and therefore inhibits its endoribonuclease activity. May play a central role in the regulation of mRNA turnover. Antagonizes the anti-viral effect of the interferon-regulated 2-5A/RNase L pathway. May act as a chaperone for post-translational events during HIV-1 capsid assembly.