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Aliases & Descriptions for ABCE1
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases ABC38 2 HuHP68 3 OABP 1 , 2 RLI 1 , 2 , 3 RNASEL1 2 , 3 RNASELI 2 , 3 , 5 RNS4I 2 , 3 , 5
Descriptions 2'-5'-oligoadenylate-binding protein 3 ATP-binding cassette, sub-family E (OABP), member 1 2 ATP-binding cassette, sub-family E, member 1 2 RNase L inhibitor 2 , 3 Ribonuclease 4 inhibitor 3 ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent) inhibitor 2
Search outside databases for aliases for ABCE1 genePrevious GC identifers: GC04P146819 GC04P146391 GC04P146597 GC04P146377
Summaries for ABCE1 (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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EntrezGene summary for ABCE1 : The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC)transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes.ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20,White). This protein is a member of the OABP subfamily. Alternatively referred to as the RNase Linhibitor, this protein functions to block the activity of ribonuclease L. Activation ofribonuclease L leads to inhibition of protein synthesis in the 2-5A/RNase L system, the centralpathway for viral interferon action. Two transcript variants encoding the same protein have beenfound for this gene. [provided by RefSeq] UniProtKB/Swiss-Prot: ABCE1_HUMAN, P61221 Function : Antagonizes the binding of 2-5A (5'-phosphorylated 2',5'-linked oligoadenylates) by RNaseL through direct interaction with RNase L and therefore inhibits its endoribonuclease activity.May play a central role in the regulation of mRNA turnover. Antagonizes the anti-viral effect ofthe interferon-regulated 2-5A/RNase L pathway. May act as a chaperone for post-translationalevents during HIV-1 capsid assembly
Genomic Location for ABCE1
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the ABCE1 gene Entrez Gene cytogenetic band: 4q31 Ensembl cytogenetic band: 4q31.22 HGNC cytogenetic band: 4q31 ABCE1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 4 GeneLoc Exon Structure
GeneLoc location for GC04P146238:
(about GC identifiers )
Start:
146,238,606 bp from pter
End:
146,270,126 bp from pter
Size:
31,521 bases
Orientation:
plus strand
RefSeq DNA sequence: NC_000004.10 NT_016354.18 Proteins for ABCE1
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: ABCE1_HUMAN, P61221 (See
protein sequence )Recommended Name: ATP-binding cassette sub-family E member 1 Size : 599 amino acids; 67314 Da
Subunit : Probably heterodimerizes with RNase L. Associates with HIV-1 Vif and HIV-1, HIV-2 and SIVGag proteins
Subcellular location : Cytoplasm. Mitochondrion. Note=Localized to clusters of virus formation atthe plasma membrane
Miscellaneous : The ABC transporter domains seem not to be functional
Secondary accessions : O88793 Q13181 Q13864 Q6NR76 Q96AL0 Q96B10 Q99K66
REFSEQ proteins (2 alternative transcripts):
NP_001035809.1 NP_002931.2 ENSEMBL proteins: ENSP00000296577 Human Recombinant Proteins               OriGene Purified Recombinant Human Protein: ABCE1 2 Gene Ontology (GO) cellular component terms (links to tree view) :
About this table Antibodies for ABCE1: Assays for ABCE1:
Protein
Domains/ Families for ABCE1(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry P61221 ProtoNet protein and cluster: P61221
2 Blocks protein families : IPB007209 Possible metal-binding region in RNase L inhibitor IPB013283 ABC transporter family E signature UniProtKB/Swiss-Prot: ABCE1_HUMAN, P61221 Similarity : Belongs to the ABC transporter family. ABCE subfamilySimilarity : Contains 2 4Fe-4S ferredoxin-type domainsSimilarity : Contains 2 ABC transporter domains
Gene Function for ABCE1
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
OriGene ,
Sigma-Aldrich , RNAi from
Sigma-Aldrich ,
RNAi Products ,
Clones , and
Q-PCR Products
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Millipore ,
OriGene , and/or
Abnova ,
siRNAs from
Applied Biosystems ,
SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_002940 Applied Biosystems Silencer ® siRNAs for ABCE1 Sigma-Aldrich siRNA for ABCE1 Sigma-Aldrich shRNA for ABCE1 Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_001040876                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_001040876                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_001040876  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_002940 UniProtKB/Swiss-Prot: ABCE1_HUMAN, P61221 Function : Antagonizes the binding of 2-5A (5'-phosphorylated 2',5'-linked oligoadenylates) by RNaseL through direct interaction with RNase L and therefore inhibits its endoribonuclease activity.May play a central role in the regulation of mRNA turnover. Antagonizes the anti-viral effect ofthe interferon-regulated 2-5A/RNase L pathway. May act as a chaperone for post-translationalevents during HIV-1 capsid assembly Induction : Activated by encephalomyocarditis virus (EMCV) and HIV-1
Genatlas biochemistry entry for ABCE1 :ATP binding cassette superfamily,subfamilyE (OABP),member 1,ubiquitously expressed 1 MGI phenotypic allele for Abce1 (no phenotypes)5/6 Gene Ontology (GO) molecular function terms (links to tree view) (see all 6
):
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Pathways & Interactions for ABCE1
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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Gene Network CentralTM Interacting Genes and Proteins Network for ABCE1 5/14 Interacting proteins for ABCE1 (ENSP00000296577 3 ) via UniProtKB, MINT, and/or STRING (see all 14
)About this table 3 Gene Ontology (GO) biological process terms (links to tree view) :
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Drugs & Compounds for ABCE1 (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Browse Tocris compounds for ABCE1
Transcripts for ABCE1(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
Millipore , and/or
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shRNA from
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_002940 Sigma-Aldrich siRNA for ABCE1 Sigma-Aldrich shRNA for ABCE1 Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_001040876 NM_002940
REFSEQ mRNAs for ABCE1 gene (2 alternative transcripts): NM_001040876.1 NM_002940.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_001040876 NM_002940
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_001040876                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_001040876                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_001040876  
Additional cDNA sequence: AB062293.1 AK123593.1 AK315198.1 BC016283.1 BC016988.1 BT009779.1 CR620765.1 X74987.1 X76388.1
13 DOTS entries : DT.448327 DT.92453076 DT.101977083 DT.95306496 DT.121341907 DT.100800662 DT.100800665 DT.99981971 DT.121275165 DT.121427773 DT.95306494 DT.99928359 DT.121275160
24/351 AceView cDNA sequences (see all 351
):BX459627 AI038729 BP337846 AK123593 AW518047 CA430799 BM785780 BM560736 AI669521 BX116792 BX489818 BM833583 AI478885 BM453111 BM974936 AI469405 BM803662 AU119568 BU508771 BU686342 T34234 BU616894 AA337780 AI191936
highest scoring ESTs for ABCE1 :X76388 AA191423 AA223912 AA386026 AA452223 AA576750 AA641324 AA644303 AA680062 AA715626
Unigene Cluster for ABCE1: ATP-binding cassette, sub-family E (OABP), member 1 Hs.12013 [show with all ESTs ] Unigene Representative Sequence: NM_002940 GeneLoc Exon Structure 5/8 Alternative Splicing Database (ASD) splice patterns (SP) for ABCE1 (see all 8
) ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b · 15c ^ 16 ^ 17a · 17b ^ 18 SP1 :                             -       -   -   -         -     SP2 :                                                   SP3 :                     -                               SP4 :                                     -   -         -     SP5 :         -   -   -   -   -   -   -   -   -     -                      
About this scheme ECgene alternative splicing isoforms for ABCE1 1 Ensembl transcript including schematic representation : ENST00000296577
Expression for ABCE1
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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ABCE1 expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for ABCE1 1 / 2 / 3
5 probe-sets matching ABCE1 gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: --SOURCE GeneReport for Unigene cluster: Hs.12013 Expression variation in blood from EXPOLDB for ABCE1
Orthologs for ABCE1
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for ABCE1 gene from 5/27 species (see all 27
)
Organism
Gene
Locus
Description
Human Similarity
NCBI accessions
dog (Canis familiaris)
ABCE11
--
ATP-binding cassette, sub-family E (OABP), member 1
95.16(n) 99.83(a)
475454 XM_532679.2 XP_532679.2
chimpanzee (Pan troglodytes)
ABCE11
--
ATP-binding cassette, sub-family E (OABP), member 1
99.89(n) 100(a)
461523 XM_517465.2 XP_517465.1
cow (Bos taurus)
ABCE11
--
ATP-binding cassette, sub-family E (OABP), member 1
94.38(n) 99.83(a)
514991 XM_592921.3 XP_592921.3
rat (Rattus norvegicus)
Abce11
--
ATP-binding cassette, sub-family E (OABP), member 1
91.43(n) 99.83(a)
361390 XM_001064797.1 XP_001064797.1
mouse (Mus musculus)
Abce11 , 5
85
ATP-binding cassette, sub-family E (OABP), member 11, 5
93.04(n) 1 100(a) 1
24015 1 NM_015751.2 1 NP_056566.2 1 AK049299 5 AK088265 5 (see all 25 )
About this table Species with no ortholog for ABCE1 ENSEMBL Gene Tree for ABCE1 Paralogs for ABCE1 (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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--
SNPs/Variants for ABCE1 (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for ABCE1 (up to first 250kb)
Disorders & Mutations for ABCE1
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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OMIM: 601213 Human Genome Epidemiology Navigator: ABCE1 (2 documents)
Medical News for ABCE1 (Possibly Related Articles in
Doctor's Guide )
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--
Publications for ABCE1 (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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10/23 PubMed articles for ABCE1 gene (see all 23
): Cloning and characterization of a RNase L inhibitor. A new component of the interferon-regulated 2-5A pathway. (PubMed id 7539425) 2, 3, 4 Bisbal C.... Salehzada T. (1995) Conservation of a stepwise, energy-sensitive pathway involving HP68 for assembly of primate lentivirus capsids in cells. (PubMed id 14747530) 3, 4 Dooher J.E. and Lingappa J.R. (2004) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 3, 4 Gerhard D.S....Malek J. (2004) Identification of a host protein essential for assembly of immature HIV-1 capsids. (PubMed id 11780123) 3, 4 Zimmerman C.... Lingappa J.R. (2002) The 2-5A/RNase L/RNase L inhibitor (RNI) pathway regulates mitochondrial mRNAs stability in interferon alpha-treated H9 cells. (PubMed id 11585831) 3, 4 Le Roy F....Salehzada T. (2001) RNase L inhibitor is induced during human immunodeficiency virus type 1 infection and down regulates the 2-5A/RNase L pathway in human T cells. (PubMed id 9847332) 3, 4 Martinand C....Bisbal C. (1999) RNase L inhibitor (RLI) antisense constructions block partially the down regulation of the 2-5A/RNase L pathway in encephalomyocarditis- virus-(EMCV)-infected cells. (PubMed id 9660177) 3, 4 Martinand C.... Bisbal C. (1998) Chromosomal localization and expression pattern of the RNase L inhibitor gene. (PubMed id 8641422) 3, 4 Aubry F.... Galibert F. (1996) Basic residues in the nucleocapsid domain of Gag are required for interaction of HIV-1 gag with ABCE1 (HP68), a cellular protein important for HIV-1 capsid assembly. (PubMed id 16275648) 1, 3 Lingappa J.R....Klein K.C. (2006) ABCE1, a member of ATP-binding cassette transporter gene, encodes peptides capable of inducing HLA-A2-restricted and tumor-reactive cytotoxic T lymphocytes in colon cancer patients. (PubMed id 15809757) 1, 3 Shichijo S....Itoh K. (2005)
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Genome Databases showing ABCE1
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
H-InvDB )
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Other Databases showing ABCE1
(According to HUGE )
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Specialized Databases showing ABCE1 (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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Name Description
SeattleSNPs http://pga.gs.washington.edu/data/abce1/
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-- Services for ABCE1 (Reagents available from Applied Biosystems , Antibodies and assays by Cell
Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
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Products for ABCE1:
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Incremental update: 13 Oct 2009