Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ABCE1 Gene

Aliases for ABCE1 Gene

  • ATP-Binding Cassette, Sub-Family E (OABP), Member 1 2 3
  • RNASELI 3 4 6
  • RNS4I 3 4 6
  • 2-5-Oligoadenylate-Binding Protein 3 4
  • Ribonuclease 4 Inhibitor 3 4
  • RNase L Inhibitor 3 4
  • RNASEL1 3 4
  • HuHP68 3 4
  • RLI 3 4
  • Ribonuclease L (2,5-Oligoisoadenylate Synthetase-Dependent) Inhibitor 3
  • ATP-Binding Cassette Sub-Family E Member 1 3
  • ABC38 3
  • OABP 3

External Ids for ABCE1 Gene

Previous HGNC Symbols for ABCE1 Gene

  • RNASEL1
  • RNASELI
  • RNS4I

Previous GeneCards Identifiers for ABCE1 Gene

  • GC04P146819
  • GC04P146391
  • GC04P146597
  • GC04P146377
  • GC04P146238
  • GC04P146019
  • GC04P141750

Summaries for ABCE1 Gene

Entrez Gene Summary for ABCE1 Gene

  • The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the OABP subfamily. Alternatively referred to as the RNase L inhibitor, this protein functions to block the activity of ribonuclease L. Activation of ribonuclease L leads to inhibition of protein synthesis in the 2-5A/RNase L system, the central pathway for viral interferon action. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for ABCE1 Gene

ABCE1 (ATP-Binding Cassette, Sub-Family E (OABP), Member 1) is a Protein Coding gene. Diseases associated with ABCE1 include hiv-1. GO annotations related to this gene include electron carrier activity and iron-sulfur cluster binding.

UniProtKB/Swiss-Prot for ABCE1 Gene

  • Antagonizes the binding of 2-5A (5-phosphorylated 2,5-linked oligoadenylates) by RNase L through direct interaction with RNase L and therefore inhibits its endoribonuclease activity. May play a central role in the regulation of mRNA turnover. Antagonizes the anti-viral effect of the interferon-regulated 2-5A/RNase L pathway. May act as a chaperone for post-translational events during HIV-1 capsid assembly.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ABCE1 Gene

Genomics for ABCE1 Gene

Regulatory Elements for ABCE1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ABCE1 Gene

Start:
145,097,932 bp from pter
End:
145,129,524 bp from pter
Size:
31,593 bases
Orientation:
Plus strand

Genomic View for ABCE1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ABCE1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ABCE1 Gene

Proteins for ABCE1 Gene

  • Protein details for ABCE1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P61221-ABCE1_HUMAN
    Recommended name:
    ATP-binding cassette sub-family E member 1
    Protein Accession:
    P61221
    Secondary Accessions:
    • O88793
    • Q13181
    • Q13864
    • Q6NR76
    • Q96AL0
    • Q96B10
    • Q99K66

    Protein attributes for ABCE1 Gene

    Size:
    599 amino acids
    Molecular mass:
    67314 Da
    Quaternary structure:
    • Probably heterodimerizes with RNASEL; this interaction inhibits the RNASEL. Associates with HIV-1 Vif and HIV-1, HIV-2 and SIV Gag proteins
    Miscellaneous:
    • The ABC transporter domains seem not to be functional

neXtProt entry for ABCE1 Gene

Proteomics data for ABCE1 Gene at MOPED

Post-translational modifications for ABCE1 Gene

  • Ubiquitination at Lys36, Lys64, Lys81, Lys93, Lys116, Lys121, Lys128, Lys158, Lys165, Lys169, Lys181, Lys191, Lys210, Lys250, Lys254, Lys332, Lys343, Lys447, Lys478, and Lys579
  • Modification sites at PhosphoSitePlus

Other Protein References for ABCE1 Gene

No data available for DME Specific Peptides for ABCE1 Gene

Domains for ABCE1 Gene

Gene Families for ABCE1 Gene

HGNC:
  • ABCE :ATP binding cassette transporters / subfamily E

Suggested Antigen Peptide Sequences for ABCE1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P61221

UniProtKB/Swiss-Prot:

ABCE1_HUMAN :
  • P61221
Domain:
  • Contains 2 4Fe-4S ferredoxin-type domains.
  • Contains 2 ABC transporter domains.
Family:
  • Belongs to the ABC transporter superfamily. ABCE family.
genes like me logo Genes that share domains with ABCE1: view

Function for ABCE1 Gene

Molecular function for ABCE1 Gene

GENATLAS Biochemistry: ATP binding cassette superfamily,subfamilyE (OABP),member 1,ubiquitously expressed
UniProtKB/Swiss-Prot Function: Antagonizes the binding of 2-5A (5-phosphorylated 2,5-linked oligoadenylates) by RNase L through direct interaction with RNase L and therefore inhibits its endoribonuclease activity. May play a central role in the regulation of mRNA turnover. Antagonizes the anti-viral effect of the interferon-regulated 2-5A/RNase L pathway. May act as a chaperone for post-translational events during HIV-1 capsid assembly.
UniProtKB/Swiss-Prot Induction: Activated by encephalomyocarditis virus (EMCV) and HIV-1.

Gene Ontology (GO) - Molecular Function for ABCE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
GO:0008428 ribonuclease inhibitor activity TAS 7539425
GO:0016887 ATPase activity IEA --
GO:0051536 iron-sulfur cluster binding IEA --
genes like me logo Genes that share ontologies with ABCE1: view

Phenotypes for ABCE1 Gene

genes like me logo Genes that share phenotypes with ABCE1: view

Animal Model Products

CRISPR Products

miRNA for ABCE1 Gene

miRTarBase miRNAs that target ABCE1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ABCE1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ABCE1 Gene

Localization for ABCE1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ABCE1 Gene

Cytoplasm. Mitochondrion. Note=Localized to clusters of virus formation at the plasma membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ABCE1 Gene COMPARTMENTS Subcellular localization image for ABCE1 gene
Compartment Confidence
mitochondrion 5
cytosol 3
nucleus 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for ABCE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005739 mitochondrion IDA 11585831
GO:0005759 mitochondrial matrix TAS --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with ABCE1: view

Pathways for ABCE1 Gene

SuperPathways for ABCE1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ABCE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006200 obsolete ATP catabolic process --
GO:0006401 RNA catabolic process TAS 7539425
GO:0009615 response to virus TAS 7539425
GO:0016032 viral process IEA --
GO:0043086 negative regulation of catalytic activity TAS 7539425
genes like me logo Genes that share ontologies with ABCE1: view

No data available for Pathways by source for ABCE1 Gene

Compounds for ABCE1 Gene

(1) Drugbank Compounds for ABCE1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Adenosine-5'-Diphosphate
20398-34-9 target
genes like me logo Genes that share compounds with ABCE1: view

Transcripts for ABCE1 Gene

Unigene Clusters for ABCE1 Gene

ATP-binding cassette, sub-family E (OABP), member 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ABCE1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ABCE1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b · 15c ^ 16 ^ 17a · 17b ^ 18
SP1: - - - - -
SP2:
SP3: -
SP4: - - -
SP5: - - - - - - - - - -
SP6: -
SP7: - - -
SP8:

Relevant External Links for ABCE1 Gene

GeneLoc Exon Structure for
ABCE1
ECgene alternative splicing isoforms for
ABCE1

Expression for ABCE1 Gene

mRNA expression in normal human tissues for ABCE1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ABCE1 Gene

SOURCE GeneReport for Unigene cluster for ABCE1 Gene Hs.12013

genes like me logo Genes that share expressions with ABCE1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ABCE1 Gene

Orthologs for ABCE1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ABCE1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ABCE1 35
  • 99.78 (n)
  • 100 (a)
ABCE1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ABCE1 35
  • 94.38 (n)
  • 99.83 (a)
ABCE1 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ABCE1 35
  • 95.16 (n)
  • 99.83 (a)
ABCE1 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Abce1 35
  • 93.04 (n)
  • 100 (a)
Abce1 16
Abce1 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ABCE1 36
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ABCE1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Abce1 35
  • 91.43 (n)
  • 99.83 (a)
chicken
(Gallus gallus)
Aves ABCE1 35
  • 85.87 (n)
  • 98.83 (a)
ABCE1 36
  • 99 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ABCE1 36
  • 97 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia abce1 35
  • 79.86 (n)
  • 94.16 (a)
zebrafish
(Danio rerio)
Actinopterygii abce1 35
  • 75.35 (n)
  • 90.32 (a)
abce1 36
  • 90 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002182 35
  • 63.82 (n)
  • 78.26 (a)
fruit fly
(Drosophila melanogaster)
Insecta pix 35
  • 66.05 (n)
  • 77.26 (a)
pix 36
  • 75 (a)
OneToOne
CG5651 37
  • 76 (a)
worm
(Caenorhabditis elegans)
Secernentea abce-1 35
  • 61.93 (n)
  • 67.34 (a)
abce-1 36
  • 65 (a)
OneToOne
Y39E4B.1 37
  • 65 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR125W 35
  • 62.48 (n)
  • 69.51 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RLI1 35
  • 64.5 (n)
  • 69.28 (a)
RLI1 36
  • 68 (a)
OneToOne
RLI1 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C17556g 35
  • 64.88 (n)
  • 68.84 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons RLI2 35
  • 67.61 (n)
  • 76.13 (a)
rice
(Oryza sativa)
Liliopsida Os11g0546000 35
  • 68.22 (n)
  • 75.96 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU03061 35
  • 61.93 (n)
  • 71.57 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rli1 35
  • 62.15 (n)
  • 65.59 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 79 (a)
OneToOne
Species with no ortholog for ABCE1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ABCE1 Gene

ENSEMBL:
Gene Tree for ABCE1 (if available)
TreeFam:
Gene Tree for ABCE1 (if available)

Paralogs for ABCE1 Gene

Pseudogenes.org Pseudogenes for ABCE1 Gene

genes like me logo Genes that share paralogs with ABCE1: view

No data available for Paralogs for ABCE1 Gene

Variants for ABCE1 Gene

Sequence variations from dbSNP and Humsavar for ABCE1 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs728674 -- 145,107,500(-) CTTGA(A/G)GTTTT intron-variant
rs959304 -- 145,107,164(-) CAAAA(C/T)AAAAC intron-variant
rs1378314 -- 145,127,431(+) CTGTT(G/T)TAAGC intron-variant
rs3756145 -- 145,107,183(-) GTCAA(C/T)TCACA intron-variant
rs3775803 -- 145,126,971(-) CAATA(C/T)AAAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ABCE1 Gene

Variant ID Type Subtype PubMed ID
dgv5779n71 CNV Loss 21882294
nsv880234 CNV Loss 21882294
nsv880235 CNV Loss 21882294
nsv880236 CNV Loss 21882294

Relevant External Links for ABCE1 Gene

HapMap Linkage Disequilibrium report
ABCE1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ABCE1 Gene

Disorders for ABCE1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for ABCE1 Gene including...

Search for ABCE1 Gene in MalaCards »

Relevant External Links for ABCE1

Genetic Association Database (GAD)
ABCE1
Human Genome Epidemiology (HuGE) Navigator
ABCE1
genes like me logo Genes that share disorders with ABCE1: view

No data available for UniProtKB/Swiss-Prot for ABCE1 Gene

Publications for ABCE1 Gene

  1. Cloning and characterization of a RNase L inhibitor. A new component of the interferon-regulated 2-5A pathway. (PMID: 7539425) Bisbal C. … Salehzada T. (J. Biol. Chem. 1995) 2 3 4
  2. Chromosomal localization and expression pattern of the RNase L inhibitor gene. (PMID: 8641422) Aubry F. … Galibert F. (FEBS Lett. 1996) 3 4
  3. RNase L inhibitor (RLI) antisense constructions block partially the down regulation of the 2-5A/RNase L pathway in encephalomyocarditis- virus-(EMCV)-infected cells. (PMID: 9660177) Martinand C. … Bisbal C. (Eur. J. Biochem. 1998) 3 4
  4. RNase L inhibitor is induced during human immunodeficiency virus type 1 infection and down regulates the 2-5A/RNase L pathway in human T cells. (PMID: 9847332) Martinand C. … Bisbal C. (J. Virol. 1999) 3 4
  5. ABCE1, a member of ATP-binding cassette transporter gene, encodes peptides capable of inducing HLA-A2-restricted and tumor-reactive cytotoxic T lymphocytes in colon cancer patients. (PMID: 15809757) Shichijo S. … Itoh K. (Oncol. Rep. 2005) 3 23

Products for ABCE1 Gene

Sources for ABCE1 Gene

Back to Top

Content