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ABCE1 Gene

protein-coding GIFtS: 57

GC04P146238

ATP-binding cassette, sub-family E (OABP), member 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: RNASEL1, RNASELI, RNS4I)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
ABC38 ^²
HuHP68 ^³
OABP ^¹, ²
RLI ^¹, ², ³
RNASEL1 ^², ³
RNASELI ^², ³, ⁵
RNS4I ^², ³, ⁵

Descriptions
2'-5'-oligoadenylate-binding protein ^³
ATP-binding cassette, sub-family E (OABP), member 1 ^²
ATP-binding cassette, sub-family E, member 1 ^²
RNase L inhibitor ^², ³
Ribonuclease 4 inhibitor ^³
ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent) inhibitor ^²

External Ids
HGNC: 69¹
Entrez Gene: 6059²
UniProtKB: P61221³
Ensembl: ENSG00000164163⁷

Search outside databases for aliases for ABCE1 gene

Previous GC identifers: GC04P146819 GC04P146391 GC04P146597 GC04P146377

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for ABCE1:

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC)

transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes.

ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20,

White). This protein is a member of the OABP subfamily. Alternatively referred to as the RNase L

inhibitor, this protein functions to block the activity of ribonuclease L. Activation of

ribonuclease L leads to inhibition of protein synthesis in the 2-5A/RNase L system, the central

pathway for viral interferon action. Two transcript variants encoding the same protein have been

found for this gene. [provided by RefSeq]

UniProtKB/Swiss-Prot: ABCE1_HUMAN, P61221

Function: Antagonizes the binding of 2-5A (5'-phosphorylated 2',5'-linked oligoadenylates) by RNase

L through direct interaction with RNase L and therefore inhibits its endoribonuclease activity.

May play a central role in the regulation of mRNA turnover. Antagonizes the anti-viral effect of

the interferon-regulated 2-5A/RNase L pathway. May act as a chaperone for post-translational

events during HIV-1 capsid assembly

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ABCE1 gene

Entrez Gene cytogenetic band: 4q31 Ensembl cytogenetic band: 4q31.22 HGNC cytogenetic band: 4q31

ABCE1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 4 GeneLoc Exon Structure

GeneLoc location for GC04P146238: (about GC identifiers)

Start:	146,238,606 bp from pter
End:	146,270,126 bp from pter
Size:	31,521 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000004.10 NT_016354.18

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: ABCE1_HUMAN, P61221 (See protein sequence)

Recommended Name: ATP-binding cassette sub-family E member 1

Size: 599 amino acids; 67314 Da

Subunit: Probably heterodimerizes with RNase L. Associates with HIV-1 Vif and HIV-1, HIV-2 and SIV

Gag proteins

Subcellular location: Cytoplasm. Mitochondrion. Note=Localized to clusters of virus formation at

the plasma membrane

Miscellaneous: The ABC transporter domains seem not to be functional

Secondary accessions: O88793 Q13181 Q13864 Q6NR76 Q96AL0 Q96B10 Q99K66

REFSEQ proteins (2 alternative transcripts):

NP_001035809.1 NP_002931.2

ENSEMBL proteins:

ENSP00000296577

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (ABCE1)
	Human Recombinant Proteins from Abnova (ABCE1)

OriGene Purified Recombinant Human Protein: ABCE1

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IDA	11585831
GO:0005739	mitochondrion	IDA	11585831

About this table

Antibodies for ABCE1:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (ABCE1), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (ABCE1)
	Novus Biologicals Antibodies for ABCE1

Assays for ABCE1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P61221

ProtoNet protein and cluster: P61221

2 Blocks protein families:

IPB007209 Possible metal-binding region in RNase L inhibitor

IPB013283 ABC transporter family E signature

UniProtKB/Swiss-Prot: ABCE1_HUMAN, P61221

Similarity: Belongs to the ABC transporter family. ABCE subfamily

Similarity: Contains 2 4Fe-4S ferredoxin-type domains

Similarity: Contains 2 ABC transporter domains

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ABCE1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ABCE1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_002940

Applied Biosystems Silencer® siRNAs for ABCE1

Sigma-Aldrich siRNA for ABCE1

Sigma-Aldrich shRNA for ABCE1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for ABCE1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001040876
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001040876
untagged cDNA clones in CMV expression vector (see all 2): NM_001040876

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_002940

UniProtKB/Swiss-Prot: ABCE1_HUMAN, P61221

Function: Antagonizes the binding of 2-5A (5'-phosphorylated 2',5'-linked oligoadenylates) by RNase

L through direct interaction with RNase L and therefore inhibits its endoribonuclease activity.

May play a central role in the regulation of mRNA turnover. Antagonizes the anti-viral effect of

the interferon-regulated 2-5A/RNase L pathway. May act as a chaperone for post-translational

events during HIV-1 capsid assembly

Induction: Activated by encephalomyocarditis virus (EMCV) and HIV-1

Genatlas biochemistry entry for ABCE1:

ATP binding cassette superfamily,subfamilyE (OABP),member 1,ubiquitously expressed

1 MGI phenotypic allele

for Abce1 (no phenotypes)

5/6 Gene Ontology (GO) molecular function terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0005524	ATP binding	IEA	--
GO:0008428	ribonuclease inhibitor activity	TAS	7539425
GO:0009055	electron carrier activity	IEA	--
GO:0016887	ATPase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for ABCE1

5/14 Interacting proteins for ABCE1 (ENSP00000296577³) via UniProtKB, MINT, and/or STRING (see all 14 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
RNASEL	ENSP00000356530³	STRING (score=.979)
RALA	ENSP00000005257³	STRING (score=.949)
EIF5	ENSP00000216554³	STRING (score=.894)
UBASH3A	ENSP00000317327³	STRING (score=.883)
CDC42P2	ENSP00000314458³	STRING (score=.864)

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3 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006401	RNA catabolic process	TAS	7539425
GO:0009615	response to virus	TAS	7539425
GO:0044419	interspecies interaction between organisms	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for ABCE1

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ABCE1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ABCE1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_002940

Sigma-Aldrich siRNA for ABCE1

Sigma-Aldrich shRNA for ABCE1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001040876 NM_002940

REFSEQ mRNAs for ABCE1 gene (2 alternative transcripts):

NM_001040876.1 NM_002940.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001040876 NM_002940

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001040876
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001040876
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_001040876

Additional cDNA sequence:

AB062293.1 AK123593.1 AK315198.1 BC016283.1 BC016988.1 BT009779.1 CR620765.1 X74987.1

X76388.1

13 DOTS entries:

DT.448327 DT.92453076 DT.101977083 DT.95306496 DT.121341907 DT.100800662 DT.100800665 DT.99981971

DT.121275165 DT.121427773 DT.95306494 DT.99928359 DT.121275160

24/351 AceView cDNA sequences (see all 351 ):

BX459627 AI038729 BP337846 AK123593 AW518047 CA430799 BM785780 BM560736

AI669521 BX116792 BX489818 BM833583 AI478885 BM453111 BM974936 AI469405

BM803662 AU119568 BU508771 BU686342 T34234 BU616894 AA337780 AI191936

highest scoring ESTs for ABCE1:

X76388 AA191423 AA223912 AA386026 AA452223 AA576750 AA641324 AA644303 AA680062 AA715626

Unigene Cluster for ABCE1:

ATP-binding cassette, sub-family E (OABP), member 1

Hs.12013 [show with all ESTs]

Unigene Representative Sequence: NM_002940

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for ABCE1 (see all 8 )

ExUns:	1a	·	1b	·	1c	^	2	^	3	^	4a	·	4b	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12a	·	12b	^	13	^	14	^	15a	·	15b	·	15c	^	16	^	17a	·	17b	^	18
SP1:																													-						-		-		-								-
SP2:
SP3:																					-
SP4:																																					-		-								-
SP5:									-		-		-		-		-		-		-		-		-				-

About this scheme

ECgene alternative splicing isoforms for ABCE1

1 Ensembl transcript including schematic representation:

ENST00000296577

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

ABCE1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ABCE1

¹ / ² / ³

5 probe-sets matching ABCE1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
39355_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	X76388	1.00	1.00	1.00	1
201873_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_002940	0.60	1.00	0.82	1
201872_s_at²^{, 3}	U133-A	3	1.00	0.48	--	--	AI002002	0.80	1.00	0.91	1
201873_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
201872_s_at²	U133Plus2	3	1.00	0.48	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.12013
Expression variation in blood from EXPOLDB for ABCE1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ABCE1 gene from 5/27 species (see all 27 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ABCE1¹	--	ATP-binding cassette, sub-family E (OABP), member 1	95.16(n) 99.83(a)	475454 XM_532679.2 XP_532679.2
chimpanzee (Pan troglodytes)	ABCE1¹	--	ATP-binding cassette, sub-family E (OABP), member 1	99.89(n) 100(a)	461523 XM_517465.2 XP_517465.1
cow (Bos taurus)	ABCE1¹	--	ATP-binding cassette, sub-family E (OABP), member 1	94.38(n) 99.83(a)	514991 XM_592921.3 XP_592921.3
rat (Rattus norvegicus)	Abce1¹	--	ATP-binding cassette, sub-family E (OABP), member 1	91.43(n) 99.83(a)	361390 XM_001064797.1 XP_001064797.1
mouse (Mus musculus)	Abce1^{1, 5}	8⁵	ATP-binding cassette, sub-family E (OABP), member 1^{1, 5}	93.04(n)¹ 100(a)¹	24015¹ NM_015751.2¹ NP_056566.2¹ AK049299⁵ AK088265⁵ (see all 25)

About this table Species with no ortholog for ABCE1

ENSEMBL Gene Tree for ABCE1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/147 NCBI SNPs in ABCE1 are shown (see all 147 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 118)

AB	SNP ID	Valid	Chr 4 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
--	rs17019897^1,2	C,F,H	146269233(+)	`GAGTTC/GCTGAA`	2	--	ut3¹ ese³		9		NA EU EA WA NS	638
	rs4148235^1,2	F,H	146268185(+)	`ACTCTG/CAGAAT`	2	--	ut3¹ ese³		4		EU EA WA	410
--	rs6537330^1,2	C	146270253(+)	`TGGGGG/TTTTTT`	2	--	ng3¹		0	--	--	--	--
--	rs9333571^1,2	F	146268599(+)	`AAGCCAGTC/- AAAGA`	2	--	ut3¹		1		EU	250
	rs34516722^1,2	F	146269952(+)	`ACTTAT/CAAAAT`	2	--	ut3¹		2		NS	90
	rs35406092^1,2	F	146252856(+)	`GATGAG/ACCTTC`	2	E/E	syn¹		2		NS	88
	rs34070877^1,2	F	146263867(+)	`CTTTGC/TTTGGG`	2	C/C	syn¹		2		NS	94
	rs6852390^1,2	A,C,F,H	146245661(+)	`ACTGAC/ATCTTA`	2	--	int¹		6		EU EA WA NS	506
	rs7681812^1,2	A,C,F,H	146260959(+)	`TAGTTC/ATTATT`	2	--	int¹		6		EU EA WA NS	510
	rs10019091^1,2	C,F,H	146254064(+)	`ACTTTT/CATggt`	2	--	int¹		6		EU EA WA NS	494

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HapMap Linkage Disequilibrium images for ABCE1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 601213

Human Genome Epidemiology Navigator: ABCE1 (2 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/23 PubMed articles for ABCE1 gene (see all 23 ):

Cloning and characterization of a RNase L inhibitor. A new component of the interferon-regulated 2-5A pathway. (PubMed id 7539425)^{2, 3, 4} Bisbal C.... Salehzada T. (1995)
Conservation of a stepwise, energy-sensitive pathway involving HP68 for assembly of primate lentivirus capsids in cells. (PubMed id 14747530)^{3, 4} Dooher J.E. and Lingappa J.R. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Identification of a host protein essential for assembly of immature HIV-1 capsids. (PubMed id 11780123)^{3, 4} Zimmerman C.... Lingappa J.R. (2002)
The 2-5A/RNase L/RNase L inhibitor (RNI) pathway regulates mitochondrial mRNAs stability in interferon alpha-treated H9 cells. (PubMed id 11585831)^{3, 4} Le Roy F....Salehzada T. (2001)
RNase L inhibitor is induced during human immunodeficiency virus type 1 infection and down regulates the 2-5A/RNase L pathway in human T cells. (PubMed id 9847332)^{3, 4} Martinand C....Bisbal C. (1999)
RNase L inhibitor (RLI) antisense constructions block partially the down regulation of the 2-5A/RNase L pathway in encephalomyocarditis- virus-(EMCV)-infected cells. (PubMed id 9660177)^{3, 4} Martinand C.... Bisbal C. (1998)
Chromosomal localization and expression pattern of the RNase L inhibitor gene. (PubMed id 8641422)^{3, 4} Aubry F.... Galibert F. (1996)
Basic residues in the nucleocapsid domain of Gag are required for interaction of HIV-1 gag with ABCE1 (HP68), a cellular protein important for HIV-1 capsid assembly. (PubMed id 16275648)^{1, 3} Lingappa J.R....Klein K.C. (2006)
ABCE1, a member of ATP-binding cassette transporter gene, encodes peptides capable of inducing HLA-A2-restricted and tumor-reactive cytotoxic T lymphocytes in colon cancer patients. (PubMed id 15809757)^{1, 3} Shichijo S....Itoh K. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 6059	HGNC: 69	AceView: ABCE1	Ensembl:ENSG00000164163	euGenes: HUgn6059
ECgene: ABCE1	H-InvDB: ABCE1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
SeattleSNPs	http://pga.gs.washington.edu/data/abce1/

Licensable Technologies for ABCE1
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for ABCE1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ABCE1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ABCE1		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for ABCE1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

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	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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	shRNA in GFP-retroviral vector

Search Tocris compounds for ABCE1

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ABCE1 Gene

protein-coding GIFtS: 57

Aliases &
Descriptions
for ABCE1

Summaries
for ABCE1

Genomic Location
for ABCE1

Proteins
for ABCE1

Protein Domains/
Families
for ABCE1

Gene Function
for ABCE1

Pathways & Interactions
for ABCE1

Drugs & Compounds
for ABCE1

Transcripts
for ABCE1

Expression
for ABCE1

Orthologs
for ABCE1

Paralogs
for ABCE1

SNPs/Variants
for ABCE1

Disorders & Mutations
for ABCE1

Medical News
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Licensable Technologies
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Services
for ABCE1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ABCE1 Gene

protein-coding GIFtS: 57

Aliases & Descriptionsfor ABCE1

Summariesfor ABCE1

Genomic Locationfor ABCE1

Proteinsfor ABCE1

Protein Domains/Familiesfor ABCE1

Gene Functionfor ABCE1

Pathways & Interactionsfor ABCE1

Drugs & Compoundsfor ABCE1

Transcriptsfor ABCE1

Expression for ABCE1

Orthologsfor ABCE1

Paralogsfor ABCE1

SNPs/Variantsfor ABCE1

Disorders & Mutationsfor ABCE1

Medical Newsfor ABCE1

Publicationsfor ABCE1

Search for ABCE1

Genome Databases showing ABCE1

Other Databases showing ABCE1

Specialized Databases showing ABCE1

Licensable Technologiesfor ABCE1

Servicesfor ABCE1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ABCE1

Summaries
for ABCE1

Genomic Location
for ABCE1

Proteins
for ABCE1

Protein Domains/
Families
for ABCE1

Gene Function
for ABCE1

Pathways & Interactions
for ABCE1

Drugs & Compounds
for ABCE1

Transcripts
for ABCE1

Expression
for ABCE1

Orthologs
for ABCE1

Paralogs
for ABCE1

SNPs/Variants
for ABCE1

Disorders & Mutations
for ABCE1

Medical News
for ABCE1

Publications
for ABCE1

Licensable Technologies
for ABCE1

Services
for ABCE1