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Aliases for ABCE1 Gene

Aliases for ABCE1 Gene

  • ATP Binding Cassette Subfamily E Member 1 2 3 5
  • ATP-Binding Cassette, Sub-Family E (OABP), Member 1 2 3
  • 2-5-Oligoadenylate-Binding Protein 3 4
  • Ribonuclease 4 Inhibitor 3 4
  • RNase L Inhibitor 3 4
  • RNASEL1 3 4
  • RNASELI 3 4
  • HuHP68 3 4
  • RNS4I 3 4
  • RLI 3 4
  • Ribonuclease L (2,5-Oligoisoadenylate Synthetase-Dependent) Inhibitor 3
  • ABC38 3
  • OABP 3

External Ids for ABCE1 Gene

Previous HGNC Symbols for ABCE1 Gene

  • RNASEL1
  • RNASELI
  • RNS4I

Previous GeneCards Identifiers for ABCE1 Gene

  • GC04P146819
  • GC04P146391
  • GC04P146597
  • GC04P146377
  • GC04P146238
  • GC04P146019
  • GC04P141750

Summaries for ABCE1 Gene

Entrez Gene Summary for ABCE1 Gene

  • The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the OABP subfamily. Alternatively referred to as the RNase L inhibitor, this protein functions to block the activity of ribonuclease L. Activation of ribonuclease L leads to inhibition of protein synthesis in the 2-5A/RNase L system, the central pathway for viral interferon action. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for ABCE1 Gene

ABCE1 (ATP Binding Cassette Subfamily E Member 1) is a Protein Coding gene. Diseases associated with ABCE1 include hiv-1. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and ABC-family proteins mediated transport. GO annotations related to this gene include ATPase activity and ribonuclease inhibitor activity.

UniProtKB/Swiss-Prot for ABCE1 Gene

  • Antagonizes the binding of 2-5A (5-phosphorylated 2,5-linked oligoadenylates) by RNase L through direct interaction with RNase L and therefore inhibits its endoribonuclease activity. May play a central role in the regulation of mRNA turnover. Antagonizes the anti-viral effect of the interferon-regulated 2-5A/RNase L pathway. May act as a chaperone for post-translational events during HIV-1 capsid assembly.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ABCE1 Gene

Genomics for ABCE1 Gene

Regulatory Elements for ABCE1 Gene

Promoters for ABCE1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ABCE1 on UCSC Golden Path with GeneCards custom track

Genomic Location for ABCE1 Gene

Chromosome:
4
Start:
145,097,932 bp from pter
End:
145,129,524 bp from pter
Size:
31,593 bases
Orientation:
Plus strand

Genomic View for ABCE1 Gene

Genes around ABCE1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ABCE1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ABCE1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ABCE1 Gene

Proteins for ABCE1 Gene

  • Protein details for ABCE1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P61221-ABCE1_HUMAN
    Recommended name:
    ATP-binding cassette sub-family E member 1
    Protein Accession:
    P61221
    Secondary Accessions:
    • O88793
    • Q13181
    • Q13864
    • Q6NR76
    • Q96AL0
    • Q96B10
    • Q99K66

    Protein attributes for ABCE1 Gene

    Size:
    599 amino acids
    Molecular mass:
    67314 Da
    Quaternary structure:
    • Probably heterodimerizes with RNASEL; this interaction inhibits the RNASEL. Associates with HIV-1 Vif and HIV-1, HIV-2 and SIV Gag proteins.
    Miscellaneous:
    • The ABC transporter domains seem not to be functional.

neXtProt entry for ABCE1 Gene

Proteomics data for ABCE1 Gene at MOPED

Post-translational modifications for ABCE1 Gene

  • Ubiquitination at Lys 36, Lys 64, Lys 81, Lys 93, Lys 116, Lys 121, Lys 128, Lys 158, Lys 165, Lys 169, Lys 181, Lys 250, Lys 254, Lys 332, Lys 343, Lys 447, Lys 478, and Lys 579
  • Modification sites at PhosphoSitePlus

Other Protein References for ABCE1 Gene

Antibody Products

No data available for DME Specific Peptides for ABCE1 Gene

Domains & Families for ABCE1 Gene

Gene Families for ABCE1 Gene

Suggested Antigen Peptide Sequences for ABCE1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P61221

UniProtKB/Swiss-Prot:

ABCE1_HUMAN :
  • Contains 2 4Fe-4S ferredoxin-type domains.
  • Belongs to the ABC transporter superfamily. ABCE family.
Domain:
  • Contains 2 4Fe-4S ferredoxin-type domains.
  • Contains 2 ABC transporter domains.
Family:
  • Belongs to the ABC transporter superfamily. ABCE family.
genes like me logo Genes that share domains with ABCE1: view

Function for ABCE1 Gene

Molecular function for ABCE1 Gene

GENATLAS Biochemistry:
ATP binding cassette superfamily,subfamilyE (OABP),member 1,ubiquitously expressed
UniProtKB/Swiss-Prot Function:
Antagonizes the binding of 2-5A (5-phosphorylated 2,5-linked oligoadenylates) by RNase L through direct interaction with RNase L and therefore inhibits its endoribonuclease activity. May play a central role in the regulation of mRNA turnover. Antagonizes the anti-viral effect of the interferon-regulated 2-5A/RNase L pathway. May act as a chaperone for post-translational events during HIV-1 capsid assembly.
UniProtKB/Swiss-Prot Induction:
Activated by encephalomyocarditis virus (EMCV) and HIV-1.

Gene Ontology (GO) - Molecular Function for ABCE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16275648
genes like me logo Genes that share ontologies with ABCE1: view
genes like me logo Genes that share phenotypes with ABCE1: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ABCE1 Gene

Localization for ABCE1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ABCE1 Gene

Cytoplasm. Mitochondrion. Note=Localized to clusters of virus formation at the plasma membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ABCE1 Gene COMPARTMENTS Subcellular localization image for ABCE1 gene
Compartment Confidence
mitochondrion 5
cytosol 3
nucleus 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for ABCE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with ABCE1: view

Pathways & Interactions for ABCE1 Gene

genes like me logo Genes that share pathways with ABCE1: view

Pathways by source for ABCE1 Gene

Gene Ontology (GO) - Biological Process for ABCE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006401 RNA catabolic process TAS 7539425
GO:0016032 viral process IEA --
genes like me logo Genes that share ontologies with ABCE1: view

No data available for SIGNOR curated interactions for ABCE1 Gene

Drugs & Compounds for ABCE1 Gene

No Compound Related Data Available

Transcripts for ABCE1 Gene

Unigene Clusters for ABCE1 Gene

ATP-binding cassette, sub-family E (OABP), member 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ABCE1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b · 15c ^ 16 ^ 17a · 17b ^ 18
SP1: - - - - -
SP2:
SP3: -
SP4: - - -
SP5: - - - - - - - - - -
SP6: -
SP7: - - -
SP8:

Relevant External Links for ABCE1 Gene

GeneLoc Exon Structure for
ABCE1
ECgene alternative splicing isoforms for
ABCE1

Expression for ABCE1 Gene

mRNA expression in normal human tissues for ABCE1 Gene

Protein differential expression in normal tissues from HIPED for ABCE1 Gene

This gene is overexpressed in Nasal epithelium (7.5) and Peripheral blood mononuclear cells (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for ABCE1 Gene



SOURCE GeneReport for Unigene cluster for ABCE1 Gene Hs.12013

genes like me logo Genes that share expression patterns with ABCE1: view

Protein tissue co-expression partners for ABCE1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ABCE1 Gene

Orthologs for ABCE1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ABCE1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ABCE1 36
  • 100 (a)
OneToOne
ABCE1 35
  • 99.78 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia ABCE1 35
  • 94.38 (n)
  • 99.83 (a)
ABCE1 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ABCE1 36
  • 100 (a)
OneToOne
ABCE1 35
  • 95.16 (n)
  • 99.83 (a)
mouse
(Mus musculus)
Mammalia Abce1 16
Abce1 35
  • 93.04 (n)
  • 100 (a)
Abce1 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ABCE1 36
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ABCE1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Abce1 35
  • 91.43 (n)
  • 99.83 (a)
chicken
(Gallus gallus)
Aves ABCE1 35
  • 85.87 (n)
  • 98.83 (a)
ABCE1 36
  • 99 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ABCE1 36
  • 97 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia abce1 35
  • 79.86 (n)
  • 94.16 (a)
zebrafish
(Danio rerio)
Actinopterygii abce1 36
  • 90 (a)
OneToOne
abce1 35
  • 75.35 (n)
  • 90.32 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002182 35
  • 63.82 (n)
  • 78.26 (a)
fruit fly
(Drosophila melanogaster)
Insecta pix 35
  • 66.05 (n)
  • 77.26 (a)
CG5651 37
  • 76 (a)
pix 36
  • 75 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea Y39E4B.1 37
  • 65 (a)
abce-1 35
  • 61.93 (n)
  • 67.34 (a)
abce-1 36
  • 65 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR125W 35
  • 62.48 (n)
  • 69.51 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RLI1 35
  • 64.5 (n)
  • 69.28 (a)
RLI1 36
  • 68 (a)
OneToOne
RLI1 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C17556g 35
  • 64.88 (n)
  • 68.84 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons RLI2 35
  • 67.61 (n)
  • 76.13 (a)
rice
(Oryza sativa)
Liliopsida Os11g0546000 35
  • 68.22 (n)
  • 75.96 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU03061 35
  • 61.93 (n)
  • 71.57 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rli1 35
  • 62.15 (n)
  • 65.59 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 79 (a)
OneToOne
Species with no ortholog for ABCE1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ABCE1 Gene

ENSEMBL:
Gene Tree for ABCE1 (if available)
TreeFam:
Gene Tree for ABCE1 (if available)

Paralogs for ABCE1 Gene

Pseudogenes.org Pseudogenes for ABCE1 Gene

genes like me logo Genes that share paralogs with ABCE1: view

No data available for Paralogs for ABCE1 Gene

Variants for ABCE1 Gene

Sequence variations from dbSNP and Humsavar for ABCE1 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs3816497 - 145,123,306(+) ACCAT(C/G)TGCAT reference, missense
rs959304 -- 145,107,164(-) CAAAA(C/T)AAAAC intron-variant
rs1378314 -- 145,127,431(+) CTGTT(G/T)TAAGC intron-variant
rs3756145 -- 145,107,183(-) GTCAA(C/T)TCACA intron-variant
rs3775803 -- 145,126,971(-) CAATA(C/T)AAAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ABCE1 Gene

Variant ID Type Subtype PubMed ID
dgv5779n71 CNV Loss 21882294
nsv880234 CNV Loss 21882294
nsv880235 CNV Loss 21882294
nsv880236 CNV Loss 21882294

Variation tolerance for ABCE1 Gene

Residual Variation Intolerance Score: 14.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.20; 4.56% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ABCE1 Gene

HapMap Linkage Disequilibrium report
ABCE1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ABCE1 Gene

Disorders for ABCE1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ABCE1 Gene - From: GeneCards

Disorder Aliases PubMed IDs
hiv-1
  • aids, slow progression to
- elite association - COSMIC cancer census association via MalaCards
Search ABCE1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for ABCE1

Genetic Association Database (GAD)
ABCE1
Human Genome Epidemiology (HuGE) Navigator
ABCE1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ABCE1
genes like me logo Genes that share disorders with ABCE1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ABCE1 Gene

Publications for ABCE1 Gene

  1. Cloning and characterization of a RNase L inhibitor. A new component of the interferon-regulated 2-5A pathway. (PMID: 7539425) Bisbal C. … Salehzada T. (J. Biol. Chem. 1995) 2 3 4 67
  2. Basic residues in the nucleocapsid domain of Gag are required for interaction of HIV-1 gag with ABCE1 (HP68), a cellular protein important for HIV-1 capsid assembly. (PMID: 16275648) Lingappa J.R. … Klein K.C. (J. Biol. Chem. 2006) 3 23
  3. ABCE1, a member of ATP-binding cassette transporter gene, encodes peptides capable of inducing HLA-A2-restricted and tumor-reactive cytotoxic T lymphocytes in colon cancer patients. (PMID: 15809757) Shichijo S. … Itoh K. (Oncol. Rep. 2005) 3 23
  4. Localization of the ribonuclease L inhibitor gene (RNS4I), a new member of the interferon-regulated 2-5A pathway, to 4q31 by fluorescence in situ hybridization. (PMID: 8838820) Diriong S. … Taviaux S. (Genomics 1996) 3 23
  5. ABCE1 is a highly conserved RNA silencing suppressor. (PMID: 25659154) KAorblane K. … Sarmiento C. (PLoS ONE 2015) 3

Products for ABCE1 Gene

Sources for ABCE1 Gene

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