Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ABCE1 Gene

protein-coding   GIFtS: 53
GCID: GC04P146019

ATP-binding cassette, sub-family E (OABP), member 1


(Previous symbols: RNASEL1, RNASELI, RNS4I)
 Explore 9 diseases affiliated with
ABCE1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ABCE1    

Aliases
for ABCE1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
ATP-Binding Cassette, Sub-Family E (OABP), Member 11 2     2'-5'-Oligoadenylate-Binding Protein2 3
RNASELI1 2 3 5     RNase L Inhibitor2 3
RNS4I1 2 3 5     ABC382
RLI1 2 3     ATP-Binding Cassette Sub-Family E Member 12
RNASEL11 2 3     HuHP683
OABP1 2     Ribonuclease L (2',5'-Oligoisoadenylate Synthetase-Dependent) Inhibitor2
Ribonuclease 4 Inhibitor2 3     HuHP683

External Ids:    HGNC: 691   Entrez Gene: 60592   Ensembl: ENSG000001641637   OMIM: 6012135   UniProtKB: P612213   

Export aliases for ABCE1 gene to outside databases

Previous GC identifers: GC04P146819 GC04P146391 GC04P146597 GC04P146377 GC04P146238 GC04P141750


Summaries
for ABCE1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ABCE1:
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC
proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven
distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the OABP subfamily.
Alternatively referred to as the RNase L inhibitor, this protein functions to block the activity of ribonuclease L.
Activation of ribonuclease L leads to inhibition of protein synthesis in the 2-5A/RNase L system, the central pathway
for viral interferon action. Two transcript variants encoding the same protein have been found for this gene.
(provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: ABCE1_HUMAN, P61221
Function: Antagonizes the binding of 2-5A (5'-phosphorylated 2',5'-linked oligoadenylates) by RNase L through direct
interaction with RNase L and therefore inhibits its endoribonuclease activity. May play a central role in the
regulation of mRNA turnover. Antagonizes the anti-viral effect of the interferon-regulated 2-5A/RNase L pathway. May
act as a chaperone for post-translational events during HIV-1 capsid assembly




Genomic Views
for ABCE1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_016354.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ABCE1 gene promoter:
         E2F-1   E2F   Pbx1a   AML1a   Cart-1   E2F-2   LCR-F1   MRF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ABCE1 promoter sequence
   Search SABiosciences Chromatin IP Primers for ABCE1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ABCE1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q31   Ensembl cytogenetic band:  4q31.21   HGNC cytogenetic band: 4q31

ABCE1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ABCE1 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P146019:  view genomic region     (about GC identifiers)

Start:
 146,019,084 bp from pter      End:
 146,050,676 bp from pter
Size:
 31,593 bases      Orientation:
 plus strand

Proteins
for ABCE1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ABCE1_HUMAN, P61221 (See protein sequence)
Recommended Name: ATP-binding cassette sub-family E member 1  
Size: 599 amino acids; 67314 Da
Subunit: Probably heterodimerizes with RNASEL; this interaction inhibits the RNASEL. Associates with HIV-1 Vif and
HIV-1, HIV-2 and SIV Gag proteins
Subcellular location: Cytoplasm. Mitochondrion. Note=Localized to clusters of virus formation at the plasma membrane
Miscellaneous: The ABC transporter domains seem not to be functional
Secondary accessions: O88793 Q13181 Q13864 Q6NR76 Q96AL0 Q96B10 Q99K66

Explore the universe of human proteins at neXtProt for ABCE1: NX_P61221

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P61221

    • ABCE1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001035809.1  NP_002931.2  

    ENSEMBL proteins: 
     ENSP00000296577   ENSP00000421250   ENSP00000422068   ENSP00000423415  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: ABCE1
    OriGene Protein Over-expression Lysate (see all 2): ABCE1
    OriGene Custom Protein Services for ABCE1 
    GenScript Custom Purified and Recombinant Proteins Services for ABCE1
    Novus Biologicals ABCE1 Proteins
    Novus Biologicals ABCE1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for ABCE1

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA11585831
    GO:0005739mitochondrion IDA11585831


    ABCE1 for ontologies           About GeneDecksing



    ABCE1 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies (see all 2): ABCE1
    OriGene Custom Antibody Services for ABCE1 
    GenScript Custom Superior Antibodies Services for ABCE1
    Novus Biologicals ABCE1 Antibodies
    Search for Antibodies for ABCE1 at Abcam  
    Uscn Antibodies for ABCE1
    ThermoFisher Antibodies for ABCE1

    Assay Products for ABCE1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ABCE1
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for ABCE1

    Protein Domains /
    Families
    for ABCE1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ABCE1 for domains           About GeneDecksing

    5/8 InterPro domains/families (see all 8):
     IPR003439 ABC_transporter-like
     IPR001450 4Fe4S-bd_dom
     IPR003593 AAA+_ATPase
     IPR017896 4Fe4S_Fe-S-bd
     IPR017900 4Fe4S_Fe_S_CS

    Graphical View of Domain Structure for InterPro Entry P61221

    ProtoNet protein and cluster: P61221

    2 Blocks protein families:
    IPB007209 Possible metal-binding region in RNase L inhibitor
    IPB013283 ABC transporter family E signature


    UniProtKB/Swiss-Prot: ABCE1_HUMAN, P61221
    Similarity: Belongs to the ABC transporter superfamily. ABCE family
    Similarity: Contains 2 4Fe-4S ferredoxin-type domains
    Similarity: Contains 2 ABC transporter domains


    Function
    for ABCE1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: ABCE1_HUMAN, P61221
    Function: Antagonizes the binding of 2-5A (5'-phosphorylated 2',5'-linked oligoadenylates) by RNase L through direct
    interaction with RNase L and therefore inhibits its endoribonuclease activity. May play a central role in the
    regulation of mRNA turnover. Antagonizes the anti-viral effect of the interferon-regulated 2-5A/RNase L pathway. May
    act as a chaperone for post-translational events during HIV-1 capsid assembly
    Induction: Activated by encephalomyocarditis virus (EMCV) and HIV-1

         Genatlas biochemistry entry for ABCE1:
    ATP binding cassette superfamily,subfamilyE (OABP),member 1,ubiquitously expressed

    miRNA
    Products:            		miRTarBase miRNAs that target ABCE1:
    hsa-mir-203 (MIRT004713)

    OriGene 3'-UTR Clone (see all 2): ABCE1
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ABCE1
    8/54 QIAGEN miScript miRNA Assays for microRNAs that regulate ABCE1 (see all 54):
    hsa-miR-579 hsa-miR-3152-3p hsa-miR-29a hsa-miR-200a hsa-miR-301a hsa-miR-374a hsa-miR-519a hsa-miR-500a
    SwitchGear 3'UTR luciferase reporter plasmid: ABCE1 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ABCE1 (see all 7)
    OriGene shRNA RFP: ABCE1
    OriGene siRNA: ABCE1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ABCE1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for ABCE1

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ABCE1 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ABCE1 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): ABCE1 (NM_001040876)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ABCE1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ABCE1 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for ABCE1
    Search LifeMap BioReagents cell lines for ABCE1

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ABCE1

    Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005524ATP binding IEA--
    GO:0008428ribonuclease inhibitor activity TAS7539425
    GO:0009055electron carrier activity IEA--
    GO:0016887ATPase activity IEA--
    GO:0046872metal ion binding ----


    ABCE1 for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for ABCE1:
     Increased S DNA content  Nuclear 60S biogenesis defects  Nucleolar pre-40S maturation d 

    Animal Models:
         1 MGI phenotypic allele for Abce1 (no phenotypes)

    ABCE1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for ABCE1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ABCE1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/110 Interacting proteins for ABCE1 (P612213 ENSP000002965774) via UniProtKB, MINT, STRING, and/or I2D (see all 110)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EIF3HO153723, ENSP000002766824I2D: score=2 STRING: ENSP00000276682
    RNASE2P101533, ENSP000003032764I2D: score=2 STRING: ENSP00000303276
    EIF3FO003033, ENSP000003100404I2D: score=1 STRING: ENSP00000310040
    UBASH3AP570753, ENSP000003173274I2D: score=1 STRING: ENSP00000317327
    RNASELQ058233, ENSP000003565304I2D: score=2 STRING: ENSP00000356530
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006401RNA catabolic process TAS7539425
    GO:0009615response to virus TAS7539425
    GO:0019048virus-host interaction IEA--
    GO:0044419interspecies interaction between organisms ----


    ABCE1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ABCE1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ABCE1

    1 DrugBank Compound for ABCE1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Adenosine-5'-Diphosphate-- 20398-34-9target--10592235

    Search CenterWatch for drugs/clinical trials and news about ABCE1 

    Transcripts
    for ABCE1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ABCE1 gene (2 alternative transcripts): 
    NM_001040876.1  NM_002940.2  

    Unigene Cluster for ABCE1:

    ATP-binding cassette, sub-family E (OABP), member 1
    Hs.12013  [show with all ESTs]
    Unigene Representative Sequence: NM_002940
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000296577(uc003ijx.3 uc003ijy.3 uc010iot.3) ENST00000502586
    ENST00000502803 ENST00000507193 ENST00000506506 ENST00000504292 ENST00000515678
    ENST00000509593 ENST00000510321 ENST00000504683

    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 2): ABCE1
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ABCE1
    8/54 QIAGEN miScript miRNA Assays for microRNAs that regulate ABCE1 (see all 54):
    hsa-miR-579 hsa-miR-3152-3p hsa-miR-29a hsa-miR-200a hsa-miR-301a hsa-miR-374a hsa-miR-519a hsa-miR-500a
    SwitchGear 3'UTR luciferase reporter plasmid: ABCE1 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ABCE1 (see all 7)
    OriGene shRNA RFP: ABCE1
    OriGene siRNA: ABCE1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ABCE1
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ABCE1 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ABCE1 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): ABCE1 (NM_001040876)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ABCE1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ABCE1 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ABCE1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ABCE1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ABCE1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ABCE1

    Additional cDNA sequence: 

    AB062293.1 AK123593.1 AK315198.1 BC016283.1 BC016988.1 BT009779.1 X74987.1 X76388.1 

    13 DOTS entries:

    DT.448327  DT.92453076  DT.101977083  DT.95306496  DT.121341907  DT.100800662  DT.100800665  DT.99981971 
    DT.121275165  DT.121427773  DT.95306494  DT.121275160  DT.99928359 

    24/351 AceView cDNA sequences (see all 351):

    BI495011 CA430799 AI253209 BU616894 AI205870 BU686342 BM970266 AI970155 
    T34234 BG741599 BX116792 AI919038 AW009691 BM457986 BU189552 BM981410 
    BM833583 BM975279 BC016283 BG571761 BM504188 AI564670 BM974936 BX489818 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for ABCE1 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b · 15c ^ 16 ^ 17a · 17b ^ 18
    SP1:                                                                                      -                 -     -     -                       -         
    SP2:                                                                                                                                                      
    SP3:                                                              -                                                                                       
    SP4:                                                                                                              -     -                       -         
    SP5:                          -     -     -     -     -     -     -     -     -           -                                                               


    ECgene alternative splicing isoforms for ABCE1

    Expression
    for ABCE1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ABCE1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See ABCE1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ABCE1

    SOURCE GeneReport for Unigene cluster: Hs.12013
        SABiosciences Custom PCR Arrays for ABCE1
    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ABCE1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ABCE1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ABCE1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ABCE1
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ABCE1

    Orthologs
    for ABCE1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the last universal common ancestor (LUCA).

    Orthologs for ABCE1 gene from 11/44 species (see all 44)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Abce11 , 5 ATP-binding cassette, sub-family E (OABP), member 11, 5 93.04(n)1
    100(a)1    		   8 (37.77 cM)5
    240151  NM_015751.21  NP_056566.21 
     796834425 
    chicken
    (Gallus gallus)    		 Aves ABCE11 ATP-binding cassette, sub-family E (OABP), member 1 85.87(n)
    98.83(a)    		   422462  NM_001006440.1  NP_001006440.1 
    lizard
    (Anolis carolinensis)    		 Reptilia ABCE16
    		 --
    		 97(a)
    		 1 ↔ 1
    		 5(117947336-117960725)
    African clawed frog
    (Xenopus laevis)    		 Amphibia BC046573.12   -- 80.04(n)    BC046573.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii AY391404.12   -- 77.91(n)    AY391404.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG56513
    pix1    		 ribonuclease inhibitor3
    pixie1    		 76(a)3
    66.11(n)1
    77.39(a)1    		   66E53
    390271  NM_168306.11  NP_729435.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea Y39E4B.13
    abce-11    		 Protein ABCE-11 65(a)3
    61.93(n)1
    67.34(a)1    		   III(13225073-13227795)3
    1767331  NM_067316.31  NP_499717.11 
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes RLI1(YDR091C)4
    RLI11    		 Essential iron-sulfur protein required for ribosome more4
    Rli1p1    		 64.44(n)1
    69.12(a)1    		   4(628534-626708)4
    8516651, 4  NP_010376.31  NP_010376.14 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons RLI21 ABC transporter E family member 2 67.45(n)
    75.79(a)    		   827661  NM_118041.4  NP_193656.2 
    rice
    (Oryza sativa)    		 Liliopsida AK102362.12   -- 76.33(n)    AK102362.1 


    ENSEMBL Gene Tree for ABCE1 (if available)
    TreeFam Gene Tree for ABCE1 (if available) 

    Paralogs
    for ABCE1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ABCE1 gene

    ABCE1 for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for ABCE1
    PGOHUM00000244380 PGOHUM00000251144 PGOHUM00000232615


    Genomic Variants
    for ABCE1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section
    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ABCE1
    DNA2.0 Custom Variant and Variant Library Synthesis for ABCE1

    Disorders / Diseases
    for ABCE1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ABCE1 for disorders           About GeneDecksing

    OMIM gene information: 601213    OMIM disorders: --

    9 diseases for ABCE1:    About MalaCards
    median neuropathy    ulnar neuropathy    neuropathy    colon cancer
    lung cancer    prostate cancer    prostatitis    immunodeficiency
    malaria

    Human Genome Epidemiology (HuGE) Navigator: ABCE1 (2 documents)

    Export disorders for ABCE1 gene to outside databases

    Publications
    for ABCE1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ABCE1 gene, integrated from 9 sources (see all 49):
    (articles sorted by number of sources associating them with ABCE1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of a RNase L inhibitor. A new component of the interferon-regulated 2-5A pathway. (PubMed id 7539425)1, 2, 3 Bisbal C.... Salehzada T. (1995)
    2. Conservation of a stepwise, energy-sensitive pathway involving HP68 for assembly of primate lentivirus capsids in cells. (PubMed id 14747530)1, 2 Dooher J.E. and Lingappa J.R. (2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Identification of a host protein essential for assembly of immature HIV-1 capsids. (PubMed id 11780123)1, 2 Zimmerman C.... Lingappa J.R. (2002)
    5. The 2-5A/RNase L/RNase L inhibitor (RNI) pathway regulates mitochondrial mRNAs stability in interferon alpha-treated H9 cells. (PubMed id 11585831)1, 2 Le Roy F....Salehzada T. (2001)
    6. RNase L inhibitor is induced during human immunodeficiency virus type 1 infection and down regulates the 2-5A/RNase L pathway in human T cells. (PubMed id 9847332)1, 2 Martinand C....Bisbal C. (1999)
    7. RNase L inhibitor (RLI) antisense constructions block partially the down regulation of the 2-5A/RNase L pathway in encephalomyocarditis- virus-(EMCV)-infected cells. (PubMed id 9660177)1, 2 Martinand C.... Bisbal C. (1998)
    8. Chromosomal localization and expression pattern of the RNase L inhibitor gene. (PubMed id 8641422)1, 2 Aubry F.... Galibert F. (1996)
    9. Basic residues in the nucleocapsid domain of Gag are required for interaction of HIV-1 gag with ABCE1 (HP68), a cellular protein important for HIV-1 capsid assembly. (PubMed id 16275648)1, 9 Lingappa J.R....Klein K.C. (2006)
    10. ABCE1, a member of ATP-binding cassette transporter gene, encodes peptides capable of inducing HLA-A2-restricted and tumor-reactive cytotoxic T lymphocytes in colon cancer patients. (PubMed id 15809757)1, 9 Shichijo S....Itoh K. (2005)

    External Searches for ABCE1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing ABCE1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6059 HGNC: 69 AceView: ABCE1 Ensembl:ENSG00000164163 euGenes: HUgn6059
    ECgene: ABCE1 H-InvDB: ABCE1

    Other Databases showing ABCE1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ABCE1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ABCE1 Pharmacogenomics, SNPs, Pathways
    SeattleSNPshttp://pga.gs.washington.edu/data/abce1/
    ABCMdbhttp://abcmutations.hegelab.org/proteinDetails?uniprot_id=P61221

    Intellectual Property
    for ABCE1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ABCE1 gene:
    Search GeneIP for patents involving ABCE1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for ABCE1 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     OriGene Antibodies for ABCE1   OriGene shRNA RFP for ABCE1  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ABCE1   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ABCE1  
     OriGene Protein Over-expression Lysate for ABCE1   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for ABCE1   OriGene 3'-UTR Clone for ABCE1  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ABCE1   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ABCE1  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for ABCE1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ABCE1   OriGene Custom Protein Services for ABCE1  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ABCE1
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ABCE1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ABCE1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ABCE1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ABCE1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ABCE1
     GenScript Custom Purified and Recombinant Proteins Services for ABCE1 GenScript cDNA clones with any tag delivered in your preferred vector for ABCE1
     GenScript Custom Assay Services for ABCE1 GenScript Custom Superior Antibodies Services for ABCE1
     GenScript Custom overexpressing Cell Line Services for ABCE1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in ABCE1 promoter
     Search Chromatin IP Primers for ABCE1
     RT2 qPCR Primer Assay in human, mouse, rat ABCE1
     GNC Network for ABCE1
     SABiosciences Custom PCR Arrays for ABCE1
     Search Tocris compounds for ABCE1
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     ABCE1 antibodies
     ABCE1 proteins
     ABCE1 lysates
     Search for Antibodies for ABCE1 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for ABCE1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     ABCE1 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for ABCE1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ABCE1
     SwitchGear 3'UTR luciferase reporter plasmids for ABCE1
     SwitchGear Promoter luciferase reporter plasmids for ABCE1
     ThermoFisher Antibodies for ABCE1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ABCE1
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      ABCE1 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4