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ABCD1 Gene

protein-coding   GIFtS: 66

GC0XP152643
ATP-binding cassette, sub-family D (ALD), member 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: ALD)
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
ABC42 2
ALD 2, 3, 5
ALDP 1, 2, 3
AMN 1, 2, 5
OTTHUMP00000025960 2
adrenoleukodystrophy 1
Descriptions
ATP-binding cassette, sub-family D (ALD), member 1 2
ATP-binding cassette, sub-family D, member 1 1
Adrenoleukodystrophy protein 2, 3
External Ids
HGNC: 611
Entrez Gene: 2152
UniProtKB: P338973
Ensembl: ENSG000001019867
Search outside databases for aliases for ABCD1 gene

Previous GC identifers: GC0XP147127 GC0XP149445 GC0XP150576 GC0XP151458 GC0XP152511

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for ABCD1:
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC)
transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes.
ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20,
White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of
fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are
half transporters which require a partner half transporter molecule to form a functional
homodimeric or heterodimeric transporter. This peroxisomal membrane protein is likely involved in
the peroxisomal transport or catabolism of very long chain fatty acids. Defects in this gene have
been identified as the underlying cause of adrenoleukodystrophy, an X-chromosome recessively
inherited demyelinating disorder of the nervous system. [provided by RefSeq]

UniProtKB/Swiss-Prot: ABCD1_HUMAN, P33897
Function: Probable transporter. The nucleotide-binding fold acts as an ATP-binding subunit with
ATPase activity

Gene Wiki entry for ABCD1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the ABCD1 gene  

Entrez Gene cytogenetic band: Xq28   Ensembl cytogenetic band:  Xq28   HGNC cytogenetic band: Xq28

ABCD1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP152643:     (about GC identifiers)

Start:
152,643,517 bp from pter
End:
152,663,410 bp from pter
Size:
19,894 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000023.9  NT_011726.13  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: ABCD1_HUMAN, P33897 (See protein sequence)
Recommended Name: ATP-binding cassette sub-family D member 1  
Size: 745 amino acids; 82937 Da
Subunit: Can form homo- and heterodimers with ABCD2/ALDR and ABCD3/PMP70. Dimerization is necessary
to form an active transporter. Interacts with PEX19
Subcellular location: Peroxisome membrane; Multi-pass membrane protein
Secondary accessions: Q6GTZ2

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_000024.2  

    ENSEMBL proteins: 
    ENSP00000218104 ENSP00000359147 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (ABCD1, ALDP)
    Human Recombinant Proteins from Abnova (ABCD1)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    5 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005777 peroxisome IEA--
    GO:0005778 peroxisomal membrane IEA--
    GO:0005779 integral to peroxisomal membrane NAS8441467
    GO:0016020 membrane IEA--
    GO:0016021 integral to membrane IEA--
    About this table

    Antibodies for ABCD1: 
    Browse Antibodies Central at Invitrogen
    Millipore Mono- and Polyclonal Antibodies for the study of ABCD1
    Sigma-Aldrich Antibodies for ABCD1
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (ABCD1, ALDP), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (ABCD1)
    Novus Biologicals Antibodies for ABCD1

    Assays for ABCD1: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    5/6 InterPro domains/families (see all 6 ):
     IPR003593 ATPase_AAA+_core
     IPR010509 ABC_Ald_N
     IPR003439 ABC_transporter-like
     IPR017940 ABC_transporter_type1
     IPR017871 ABC_transporter_CS


       GeneDecks  ABCD1 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry P33897

    ProtoNet protein and cluster: P33897

    1 Blocks protein family: IPB010509 ABC transporter

    UniProtKB/Swiss-Prot: ABCD1_HUMAN, P33897
    Similarity: Belongs to the ABC transporter family. ALD subfamily
    Similarity: Contains 1 ABC transmembrane type-1 domain
    Similarity: Contains 1 ABC transporter domain

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (ABCD1)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (ABCD1)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000033

                  Applied Biosystems Silencer® siRNAs for ABCD1

                  Sigma-Aldrich siRNA and siRNA Panels for ABCD1  
                         Sigma-Aldrich shRNA for ABCD1  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for ABCD1
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_000033
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_000033
                                     untagged cDNA clone in CMV expression vector: NM_000033 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_000033

    UniProtKB/Swiss-Prot: ABCD1_HUMAN, P33897
    Function: Probable transporter. The nucleotide-binding fold acts as an ATP-binding subunit with
    ATPase activity

    Genatlas biochemistry entry for ABCD1:
    ATP-binding cassette superfamily,subfamily D (ALD),member 1,peroxisomal membrane protein,enhancing
    the association of very long chain acyl-CoA synthethase with the peroxisome

    8 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Abcd1):

    behavior/neurologicalendocrine/exocrine glandhematopoietic systemhomeostasis/metabolismimmune system
    nervous systemnormalreproductive system

    5/6 Gene Ontology (GO) molecular function terms (links to tree view) (see all 6 ):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166 nucleotide binding IEA--
    GO:0005215 transporter activity NAS8441467
    GO:0005524 ATP binding IEA--
    GO:0016887 ATPase activity IEA--
    GO:0042626 ATPase activity, coupled to transmembrane movement of substances NAS8441467
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


    1 Kegg Pathway  (Kegg details for ABCD1):
     hsa02010 ABC transporters

       GeneDecks  ABCD1 for the pathways selected above  
    About GeneDecksing
     Gene Network CentralTM Interacting Genes and Proteins Network for  ABCD1 


    5/32 Interacting proteins for ABCD1 (ENSP000002181043 P338971) via UniProtKB, MINT, and/or STRING (see all 32 )
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ABCD3P282881STRING (score=.723) EBI-81045, EBI-80992
    ABCD1P338971EBI-81045, EBI-81045
    Abcd1 Abcd1 (xeno)P484101EBI-81045, EBI-81118
    Abcd3 Abcd3 (xeno)P550961EBI-81045, EBI-81160
    PEX19ENSP000003570513STRING (score=.994)
    About this table

    3 Gene Ontology (GO) biological process terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810 transport IEA--
    GO:0007031 peroxisome organization NAS8441467
    GO:0015919 peroxisomal membrane transport NAS8441467
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for ABCD1
    10 Novoseek chemical compound relationships for ABCD1 gene
    Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    lignoceric acid 74.99 4 9007322 (2), 9799802 (1)
    fatty acid 64.51 21 2015112 (2), 18491823 (1), 9051655 (1), 16223892 (1) (see all 14)
    acyl-coa 58.19 3 9173925 (2), 10068511 (1)
    manganese superoxide 24.36 1 16319717 (1)
    atp 19.64 18 16946495 (3), 12530690 (2), 11248239 (2), 9425230 (1) (see all 10)
    lipid 10.11 4 17973979 (1), 2015112 (1), 17881773 (1), 17532287 (1)
    forskolin 0.00 1 9610777 (1)
    cholesterol 0.00 2 16213491 (1), 17881773 (1)
    adp 0.00 1 16946495 (1)
    proline 0.00 1 15192815 (1)
    About this table


    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (ABCD1)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (ABCD1)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000033

                  Sigma-Aldrich siRNA and siRNA Panels for ABCD1  
                         Sigma-Aldrich shRNA for ABCD1  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_000033  

    REFSEQ mRNAs for ABCD1 gene: 

    NM_000033.3   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_000033  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_000033
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_000033
                                     untagged cDNA clone in CMV expression vector: NM_000033 

    Additional cDNA sequence: 

    AY421736.1 AY421737.1 AY421738.1 BC015541.1 BC025358.1 CR590818.1 CR599919.1 Z21876.1 

    9 DOTS entries:

    DT.100775286  DT.438401  DT.97780533  DT.91751960  DT.99946409  DT.100698232  DT.121309356  DT.121309416 
    DT.95174234 

    24/167 AceView cDNA sequences (see all 167 ):

    AA617973 BQ002137 CA395588 BX281679 BQ945290 NM_000033 BQ689178 BQ051707 
    BQ233874 BE280899 BX382184 BX379103 D31532 Z21876 BM743389 CR599919 
    BE546548 BF111256 BM744752 BC015541 BC025358 CR590818 BU188300 BM459113 

    highest scoring ESTs for ABCD1:

    AI762804 AA354923 AA617973 AA758000 AI082239 AI356337 AI871975 AL135144 AW960070 BC015541 

    Unigene Cluster for ABCD1:

    ATP-binding cassette, sub-family D (ALD), member 1
    Hs.159546  [show with all ESTs]
    Unigene Representative Sequence: NM_000033


    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for ABCD1

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b
    SP1:                                -     -                 -                                                   
    SP2:                                                                                                            
    SP3:                                                        -                                                   
    SP4:                                      -                 -                                                   
    SP5:                                                                                                            

    About this scheme

    ECgene alternative splicing isoforms for ABCD1

    2 Ensembl transcripts including schematic representations:
    ENST00000218104  ENST00000370129  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    ABCD1 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for ABCD1

    1 / 2 / 3

    4 probe-sets matching ABCD1 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    89043_at2, 3 U95-E 2 1.00 0.94 0.81 1.36 AI762804 1.00 1.00 1.00 1

    33603_at2, 3 U95-A 4 1.00 0.42 0.72 0.66 U52111 0.20 0.20 0.20 1

    205142_x_at2, 3 U133-A 1 1.00 1.00 -- -- NM_000033 0.60 1.00 0.82 1

    205142_x_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    GeneDecks  ABCD1 for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: TTCCCAGCTC

    SOURCE GeneReport for Unigene cluster: Hs.159546

    Expression variation in blood from EXPOLDB for ABCD1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for ABCD1 gene from 5/10 species (see all 10 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    ABCD11   -- ATP-binding cassette, sub-family D (ALD), member 1 89.77(n)
    92.6(a)
    612520  XM_850248.1  XP_855341.1 
    cow
    (Bos taurus)
    ABCD11   -- ATP-binding cassette, sub-family D (ALD), member 1 88.48(n)
    91.53(a)
    515178  NM_001046190.1  NP_001039655.1 
    rat
    (Rattus norvegicus)
    Abcd11   -- ATP-binding cassette, sub-family D (ALD), member 1 86.48(n)
    91.53(a)
    363516  XM_343840.3  XP_343841.1 
    mouse
    (Mus musculus)
    Abcd11, 5 X (29.50 cM)5
    ATP-binding cassette, sub-family D (ALD), member 11, 5 86.61(n)1
    92.08(a)1
    116661  NM_007435.11  NP_031461.11 
     AA0077555  AF1330935  (see all 19)
    zebrafish
    (Danio rerio)
    zgc:1721021   -- zgc:172102 67.82(n)
    69.9(a)
    566367  NM_001111186.1  NP_001104656.1 
    About this table        Species with no ortholog for ABCD1

    ENSEMBL Gene Tree for ABCD1
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for ABCD1 gene
    ABCD32  ENSG000002143302  ABCD42  ABCD22  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/80 NCBI SNPs in ABCD1 are shown (see all 80 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 31)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr X posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    --
    rs66437831,2
    A,C,H152663427(+) GTGGTG/ATCTGC 1 -- ng314Minor allele frequency- A:0.00EU EA WA 408
    --
    rs118031,2
    A,C,F152663260(-) CCCCTG/AGTGAC 1 -- ut31 ese31Minor allele frequency- A:0.22MN 184
    --
    rs66437851,2
    A,C,F152663571(+) CCCTCC/TGCCGA 1 -- ng313Minor allele frequency- T:0.06NA 136
    --
    rs66437841,2
    A,C152663461(+) GGAGAA/GGGAGT 1 -- ng310--------
    --
    rs22295391,2
    A,F152662391(+) CAACCC/GTCCCC 1 -- ut31 ese31Minor allele frequency- G:0.26MN 38
    --
    rs59451591,2
    A,C152663803(+) GGAACC/TGGGAG 1 -- ng310--------
    --
    rs59453421,2
    A,C152663678(+) GGGGAA/GGGGAT 1 -- ng310--------
    --
    rs66437821,2
    A,C152663418(+) CAGAGC/TCTGGT 1 -- ng310--------
    --
    rs66436431,2
    A,C,F,H152659853(+) TGTCAA/GGAGGT 1 -- int17Minor allele frequency- G:0.28EU EA WA NA 558
    rs65712921,2
    A,C,F,H152650471(+) AATAGG/AAATTT 1 -- int14Minor allele frequency- A:0.28EU EA WA 418
    About this table

    HapMap Linkage Disequilibrium images for ABCD1 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 300371   disorders: 300100  300100  

    UniProtKB/Swiss-Prot: ABCD1_HUMAN, P33897

  • Defects in ABCD1 are the cause of adrenoleukodystrophy X-linked (X-ALD) [MIM:300100].
    X-ALD is a peroxisomal metabolic disorder characterized by progressive multifocal demyelination of
    the central nervous system and by peripheral adrenal insufficiency (Addison disease). It results
    in mental deterioration, corticospinal tract dysfunction, and cortical blindness. Different
    clinical manifestations exist like: cerebral childhood ALD (CALD), adult cerebral ALD (ACALD),
    adrenomyeloneuropathy (AMN) and "Addison disease only" (ADO) phenotype
  • Microdeletions in ABCD1 are involved in the contiguous ABCD1/DXS1375E deletion syndrome
    (CADDS) [MIM:300475]. Patients manifest profound neonatal hypotonia, subsequent failure to thrive,
    and cholestatic liver disease
  • 9 Novoseek disease relationships for ABCD1 gene

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    adrenoleukodystrophy 98.64 185 16087056 (3), 17662307 (3), 17609205 (3), 8892025 (2) (see all 97)
    peroxisomal disorders 90.70 7 15643618 (1), 18491823 (1), 9195223 (1), 7919919 (1) (see all 7)
    demyelination 71.11 7 9173925 (2), 9195223 (1), 10319888 (1), 17532287 (1) (see all 6)
    demyelinating diseases 68.08 14 9607414 (1), 8577752 (1), 11706205 (1), 9266848 (1) (see all 9)
    adrenal dysfunction 61.45 1 17202797 (1)
    addisons disease 61.11 3 17532287 (2), 7717396 (1)
    neurodegenerative diseases 60.34 17 17686565 (1), 18973459 (1), 11422379 (1), 11063720 (1) (see all 11)
    metabolic disorder 22.26 4 18723473 (2)
    multiple sclerosis 0.00 1 11688182 (1)
    About this table

    GeneTests: ABCD1
    Adrenoleukodystrophy

    Human Gene Mutation Database: ABCD1
    Human Genome Epidemiology Navigator: ABCD1 (3 documents)

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/175 PubMed articles for ABCD1 gene (see all 175 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 215 HGNC: 61 AceView: ABCD1 Ensembl:ENSG00000101986 euGenes: HUgn215
    ECgene: ABCD1 H-InvDB: ABCD1
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

    NameDescription
    X-ALD gene mutation databasehttp://www.x-ald.nl/
    GeneReviewshttp://www.genetests.org/query?gene=ABCD1
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for ABCD1:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
      Invitrogen Clones  Invitrogen Q-PCR Products
      Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for ABCD1-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


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     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
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