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ABCC9 Gene

protein-coding GIFtS: 63

GC12M021844

ATP-binding cassette, sub-family C (CFTR/MRP), member 9
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
ABC37 ^²
CMD1O ^¹, ², ⁵
FLJ36852 ^²
SUR2 ^¹, ², ³, ⁵

Descriptions
ATP-binding cassette, sub-family C (CFTR/MRP), member 9 ^²
ATP-binding cassette, sub-family C, member 9 ^²
Sulfonylurea receptor 2 ^³
sulfonylurea receptor 2A ^²

External Ids
HGNC: 60¹
Entrez Gene: 10060²
UniProtKB: O60706³
Ensembl: ENSG00000069431⁷

Search outside databases for aliases for ABCC9 gene

Previous GC identifers: GC12M022239 GC12M021955 GC12M021852 GC12M021845

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for ABCC9:

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC)

transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes.

ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20,

White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance.

This protein is thought to form ATP-sensitive potassium channels in cardiac, skeletal, and

vascular and non-vascular smooth muscle. Protein structure suggests a role as the drug-binding

channel-modulating subunit of the extrapancreatic ATP-sensitive potassium channels. No disease has

been associated with this gene thus far. Alternative splicing of this gene results in several

products, two of which result from differential usage of two terminal exons and one of which

results from exon deletion. [provided by RefSeq]

UniProtKB/Swiss-Prot: ABCC9_HUMAN, O60706

Function: Subunit of ATP-sensitive potassium channels (KATP). Can form cardiac and smooth

muscle-type KATP channels with KIR6.2. KIR6.2 forms the channel pore while SUR2 is required for

activation and regulation

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ABCC9 gene

Entrez Gene cytogenetic band: 12p12.1 Ensembl cytogenetic band: 12p12.1 HGNC cytogenetic band: 12p12.1

ABCC9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12M021844: (about GC identifiers)

Start:	21,841,590 bp from pter
End:	21,985,603 bp from pter
Size:	144,014 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000012.10 NT_009714.16

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: ABCC9_HUMAN, O60706 (See protein sequence)

Recommended Name: ATP-binding cassette transporter sub-family C member 9

Size: 1549 amino acids; 174223 Da

Subcellular location: Membrane; Multi-pass membrane protein (Potential)

Secondary accessions: O60707

Alternative splicing: 2 isoforms: O60706-1 O60706-2

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (3 alternative transcripts):

NP_005682.2 NP_064693.2 NP_064694.2

ENSEMBL proteins:

ENSP00000261201 ENSP00000317518 ENSP00000261200 ENSP00000261202

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (ABCC9)
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008282	ATP-sensitive potassium channel complex	ISS	--
GO:0016020	membrane	IEA	--
GO:0016021	integral to membrane	IEA	--

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Antibodies for ABCC9:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for ABCC9
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (ABCC9), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for ABCC9

Assays for ABCC9:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry O60706

ProtoNet protein and cluster: O60706

2 Blocks protein families:

IPB000388 Sulphonylurea receptor family signature

IPB001475 Sulphonylurea receptor type 2 family signature

UniProtKB/Swiss-Prot: ABCC9_HUMAN, O60706

Similarity: Belongs to the ABC transporter family. Conjugate transporter (TC 3.A.1.208) subfamily

Similarity: Contains 2 ABC transmembrane type-1 domains

Similarity: Contains 2 ABC transporter domains

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ABCC9)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ABCC9)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_020297

Applied Biosystems Silencer® siRNAs for ABCC9

Sigma-Aldrich siRNA and siRNA Panels for ABCC9

Sigma-Aldrich shRNA for ABCC9

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for ABCC9
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_005691
Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_005691
untagged cDNA clones in CMV expression vector (see all 4): BC033804

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_020297

UniProtKB/Swiss-Prot: ABCC9_HUMAN, O60706

Function: Subunit of ATP-sensitive potassium channels (KATP). Can form cardiac and smooth

muscle-type KATP channels with KIR6.2. KIR6.2 forms the channel pore while SUR2 is required for

activation and regulation

Genatlas biochemistry entry for ABCC9:

ATP-binding cassette superfamily,subfamily C (CFTR/MRP),member 9

5 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Abcc9):

growth/size

homeostasis/metabolism

life span-post-weaning/aging

muscle

5/8 Gene Ontology (GO) molecular function terms (links to tree view) (see all 8 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0004872	receptor activity	IEA	--
GO:0005215	transporter activity	TAS	8826984
GO:0005524	ATP binding	IEA	--
GO:0008281	sulfonylurea receptor activity	TAS	8826984

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

2 Interacting proteins for ABCC9 (ENSP00000261201³) via UniProtKB, MINT, and/or STRING

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
KCNJ11	ENSP00000345708³	STRING (score=.936)
KCNJ8	ENSP00000240662³	STRING (score=.855)

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3 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006810	transport	IEA	--
GO:0010107	potassium ion import	ISS	--
GO:0051607	defense response to virus	IMP	18026101

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for ABCC9
6 Novoseek chemical compound relationships for ABCC9 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
sulfonylurea	92.64	18	16672225 (2), 17110465 (1), 10469651 (1), 8630239 (1) (see all 16)
katp	91.91	36	8826984 (2), 10224138 (2), 11054556 (2), 10099692 (1) (see all 27)
mgatp	71.55	4	10436001 (1), 12145099 (1), 15023854 (1), 11714894 (1)
mgadp	71.27	3	12145099 (1), 11714894 (1), 12475777 (1)
potassium	65.77	4	10469651 (1), 10436001 (1), 18316485 (1), 12959913 (1)
atp	45.02	15	10436001 (4), 10224138 (2), 9692785 (1), 9755153 (1) (see all 7)

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2 PharmGKB drug compound relationships for ABCC9 gene

Drug compound	PharmGKB Relations	PubMed IDs for articles supporting these relationships
antiarrhythmics	FA	8630239
diazoxide	FA	8630239

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ABCC9)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ABCC9)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_020297

Sigma-Aldrich siRNA and siRNA Panels for ABCC9

Sigma-Aldrich shRNA for ABCC9

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_005691 NM_020297 NM_020298

REFSEQ mRNAs for ABCC9 gene (3 alternative transcripts):

NM_005691.2 NM_020297.2 NM_020298.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_005691 NM_020297 NM_020298

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_005691
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_005691
                                 untagged cDNA clones in CMV expression vector (see all 4): BC033804

Additional cDNA sequence:

AK056519.1 AK092535.1 AK094171.1 BC033804.1 BX537513.1 BX640893.1 CR619334.1

5 DOTS entries:

DT.40189058 DT.315094 DT.95267937 DT.99932355 DT.99954570

24/56 AceView cDNA sequences (see all 56 ):

CR619334 BE148672 AK092535 CA389699 CA390366 AA687622 AA233923 AA716277

AA329631 AW172466 BX640893 AK056519 BG564434 AA234172 BQ004763 BX432024

CA389496 BX104670 NM_020297 AI015113 CD630005 BX499619 AA452215 NM_020298

highest scoring ESTs for ABCC9:

BI763735 BX497417 H16193 R73927 AA234172 AA452215 AK056519 AW172466 BC033804 BE550227

Unigene Cluster for ABCC9:

ATP-binding cassette, sub-family C (CFTR/MRP), member 9

Hs.446050 [show with all ESTs]

Unigene Representative Sequence: NM_020297

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for ABCC9

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5	^	6	^	7a	·	7b	^	8	^	9	^	10	^	11	^	12	^	13	^	14	^	15	^	16	^	17	^	18	^	19	^	20	^	21
SP1:
SP2:															-
SP3:							-

About this scheme

ECgene alternative splicing isoforms for ABCC9

4 Ensembl transcripts including schematic representations:

ENST00000261201 ENST00000326684 ENST00000261200 ENST00000345162

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

ABCC9 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ABCC9

¹ / ² / ³

13 probe-sets matching ABCC9 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
75176_at²^{, 3}	U95-E	1	1.00	1.00	0.96	2.01	AA234172	0.60	1.00	0.82	1
37260_at²^{, 3}	U95-A	1	1.00	1.00	0.92	0.62	AF061324	0.20	1.00	0.72	1
37262_at²^{, 3}	U95-A	1	0.94	1.00	0.26	1.13	AF061324	0.20	1.00	0.72	1
37261_g_at²^{, 3}	U95-A	2	0.94	0.97	0.96	0.48	AF061324	0.20	1.00	0.72	1
208561_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_020297	0.60	1.00	0.82	1
208562_s_at²^{, 3}	U133-A	2	1.00	0.95	--	--	NM_020297	0.60	1.00	0.82	1
208462_s_at²^{, 3}	U133-A	1	0.91	1.00	--	--	NM_005691	0.60	1.00	0.82	1
206323_x_at²	U133-A	32	0.82	0.10	--	--	--	--	--	--	--
1557374_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
208561_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
208562_s_at²	U133Plus2	2	1.00	0.95	--	--	--	--	--	--	--
208462_s_at²	U133Plus2	1	0.91	1.00	--	--	--	--	--	--	--
206323_x_at²	U133Plus2	32	0.82	0.10	--	--	--	--	--	--	--

GeneDecks ABCC9 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.446050
Expression variation in blood from EXPOLDB for ABCC9

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ABCC9 gene from 5/12 species (see all 12 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ABCC9¹	--	ATP-binding cassette, sub-family C (CFTR/MRP), member more	92.81(n) 98.77(a)	486638 XM_847653.1 XP_852746.1
chimpanzee (Pan troglodytes)	ABCC9¹	--	ATP-binding cassette, sub-family C (CFTR/MRP), member more	99.74(n) 99.94(a)	465338 XM_001149571.1 XP_001149571.1
cow (Bos taurus)	ABCC9¹	--	ATP-binding cassette, sub-family C (CFTR/MRP), member more	91.85(n) 98.53(a)	522913 XM_601202.3 XP_601202.3
rat (Rattus norvegicus)	Abcc9¹	--	ATP-binding cassette, sub-family C (CFTR/MRP), member more	85.13(n) 97.22(a)	25560 NM_013040.2 NP_037172.2
mouse (Mus musculus)	Abcc9^{1, 5}	6 (70.00 cM)⁵	ATP-binding cassette, sub-family C (CFTR/MRP), member more^{1, 5}	85.96(n)¹ 97.09(a)¹	20928¹ NM_011511.2¹ NP_035641.1¹ AF003531⁵ AI414027⁵ (see all 14)

About this table Species with no ortholog for ABCC9

ENSEMBL Gene Tree for ABCC9

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for ABCC9 gene

ABCC10² CFTR² ABCC8²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/787 NCBI SNPs in ABCC9 are shown (see all 787 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 287)

AB	SNP ID	Valid	Chr 12 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs7316271^1,2	A,C,F,H	21981729(+)	`agtgaT/Cgtgct`	3	--	ng3¹		8	EU EA WA	838
	rs11835091^1,2	A,C,F,H	21841965(+)	`GTGCAT/CAATTG`	1	--	ut3¹		4	EU EA WA	418
	rs11615310^1,2	A,C,F,H	21982585(+)	`AAGGTA/GTTAAT`	3	--	ng3¹		4	EU EA WA	418
	rs11832676^1,2	C,F,H	21841862(+)	`GTCCCG/AAATCT`	1	--	ut3¹		4	EU EA WA	418
	rs10734715^1,2	C,H	21981765(+)	`tattaT/Atgctg`	3	--	ng3¹		4	EU EA WA	420
	rs3809206^1,2	F,H	21981342(-)	`ACTCTG/ATCACA`	3	--	ng3¹		5	EA EU WA	1724
	rs1283784^1,2	F,H	21844726(+)	`AGGCTC/GTTAAG`	1	--	ut3¹		4	EU EA WA	416
	rs829063^1,2	F,H	21844204(+)	`TGATCA/TTGTGT`	1	--	ut3¹		4	EU EA WA	418
	rs4148681^1,2	H	21849178(-)	`TGTGTT/GTTCAA`	3	--	ng5¹ int¹		4	EU EA WA	416
--	rs17630922^1,2	F	21849105(+)	`GAAATT/GGGTCC`	3	--	ng5¹ int¹		3	NA	142

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HapMap Linkage Disequilibrium images for ABCC9 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 601439 disorders: 608569

UniProtKB/Swiss-Prot: ABCC9_HUMAN, O60706

Defects in ABCC9 are the cause of cardiomyopathy dilated type 1O (CMD1O) [MIM:608569];

also known as dilated cardiomyopathy with ventricular tachycardia. Dilated cardiomyopathy is a

disorder characterized by ventricular dilation and impaired systolic function, resulting in

congestive heart failure and arrhythmia. Patients are at risk of premature death

1 Novoseek disease relationship for ABCC9 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
necrosis	0.00	1	16829188 (1)

About this table

GeneTests: ABCC9

Dilated Cardiomyopathy

Human Gene Mutation Database: ABCC9
Human Genome Epidemiology Navigator: ABCC9 (2 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/81 PubMed articles for ABCC9 gene (see all 81 ):

ABCC9 mutations identified in human dilated cardiomyopathy disrupt catalytic KATP channel gating. (PubMed id 15034580)^{2, 3, 4} Bienengraeber M....Terzic A. (2004)
Toward understanding the assembly and structure of KATP channels. (PubMed id 9457174)^{2, 3, 4} Aguilar-Bryan L.... Bryan J. (1998)
A family of sulfonylurea receptors determines the pharmacological properties of ATP-sensitive K+ channels. (PubMed id 8630239)^{1, 3, 7} Inagaki N....Seino S. (1996)
Cloning, tissue expression, and chromosomal localization of SUR2, the putative drug-binding subunit of cardiac, skeletal muscle, and vascular KATP channels. (PubMed id 8826984)^{1, 3} Chutkow W.A....Burant C.F. (1996)
Molecular characterization of human SUR2-containing K(ATP) channels. (PubMed id 11054556)^{1, 3} Davis-Taber R....Scott V.E. (2000)
Syntaxin-1A actions on sulfonylurea receptor 2A can block acidic pH-induced cardiac K(ATP) channel activation. (PubMed id 16672225)^{1, 3} Kang Y....Gaisano H.Y. (2006)
Syntaxin-1A inhibits cardiac KATP channels by its actions on nucleotide binding folds 1 and 2 of sulfonylurea receptor 2A. (PubMed id 15339904)^{1, 3} Kang Y....Gaisano H.Y. (2004)
SUR2 subtype (A and B)-dependent differential activation of the cloned ATP-sensitive K+ channels by pinacidil and nicorandil. (PubMed id 9692785)^{1, 3} Shindo T....Kurachi Y. (1998)
Pharmaco-topology of sulfonylurea receptors. Separate domains of the regulatory subunits of K(ATP) channel isoforms are required for selective interaction with K(+) channel openers. (PubMed id 10625598)^{1, 3} Babenko A.P....Bryan J. (2000)
Potassium channel openers require ATP to bind to and act through sulfonylurea receptors. (PubMed id 9755153)^{1, 3} Schwanstecher M....Bryan J. (1998)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 10060	HGNC: 60	AceView: ABCC9	Ensembl:ENSG00000069431	euGenes: HUgn10060
ECgene: ABCC9	H-InvDB: ABCC9

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
GeneReviews	http://www.genetests.org/query?gene=ABCC9

Licensable Technologies for ABCC9
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for ABCC9:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ABCC9-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ABCC9		Antibodies for ABCC9
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for ABCC9		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Search for Recombinant Proteins
	Search for Antibodies
	Chimera RNAi (ABCC9)
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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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ABCC9 Gene at Home site.
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ABCC9 Gene

protein-coding GIFtS: 63

Aliases &
Descriptions
for ABCC9

Summaries
for ABCC9

Genomic Location
for ABCC9

Proteins
for ABCC9

Protein Domains/
Families
for ABCC9

Gene Function
for ABCC9

Pathways & Interactions
for ABCC9

Drugs & Compounds
for ABCC9

Transcripts
for ABCC9

Expression
for ABCC9

Orthologs
for ABCC9

Paralogs
for ABCC9

SNPs/Variants
for ABCC9

Disorders & Mutations
for ABCC9

Medical News
for ABCC9

Publications
for ABCC9

Search for ABCC9

Genome Databases showing ABCC9

Other Databases showing ABCC9

Specialized Databases showing ABCC9

Licensable Technologies
for ABCC9

Services
for ABCC9

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ABCC9 Gene

protein-coding GIFtS: 63

Aliases & Descriptionsfor ABCC9

Summariesfor ABCC9

Genomic Locationfor ABCC9

Proteinsfor ABCC9

Protein Domains/Familiesfor ABCC9

Gene Functionfor ABCC9

Pathways & Interactionsfor ABCC9

Drugs & Compoundsfor ABCC9

Transcriptsfor ABCC9

Expression for ABCC9

Orthologsfor ABCC9

Paralogsfor ABCC9

SNPs/Variantsfor ABCC9

Disorders & Mutationsfor ABCC9

Medical Newsfor ABCC9

Publicationsfor ABCC9

Search for ABCC9

Genome Databases showing ABCC9

Other Databases showing ABCC9

Specialized Databases showing ABCC9

Licensable Technologiesfor ABCC9

Servicesfor ABCC9

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ABCC9

Summaries
for ABCC9

Genomic Location
for ABCC9

Proteins
for ABCC9

Protein Domains/
Families
for ABCC9

Gene Function
for ABCC9

Pathways & Interactions
for ABCC9

Drugs & Compounds
for ABCC9

Transcripts
for ABCC9

Expression
for ABCC9

Orthologs
for ABCC9

Paralogs
for ABCC9

SNPs/Variants
for ABCC9

Disorders & Mutations
for ABCC9

Medical News
for ABCC9

Publications
for ABCC9

Licensable Technologies
for ABCC9

Services
for ABCC9