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ABCC6 Gene

protein-coding   GIFtS: 65

GC16M016151
ATP-binding cassette, sub-family C (CFTR/MRP), member 6
(Previous name: pseudoxanthoma elasticum )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: ARA, PXE)
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases
ABC34 2, 5
ARA 2, 3, 5
EST349056 1, 2
MLP1 1, 2, 5
MOAT-E 3
MOATE 2
MRP6 1, 2, 3
PXE 2, 5
PXE1 2
Descriptions
ATP-binding cassette sub-family C member 6 3
ATP-binding cassette, sub-family C (CFTR/MRP), member 6 2
ATP-binding cassette, sub-family C, member 6 2
Anthracycline resistance-associated protein 2, 3
Multi-specific organic anion transporter E 3
pseudoxanthoma elasticum 1
External Ids
HGNC: 571
Entrez Gene: 3682
UniProtKB: O952553
Ensembl: ENSG000000912627
Search outside databases for aliases for ABCC6 gene

Previous GC identifers: GC16M016071 GC16M015526 GC16M016210

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for ABCC6:
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC)
transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes.
ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20,
White). The encoded protein, a member of the MRP subfamily, is involved in multi-drug resistance.
Mutations in this gene cause pseudoxanthoma elasticum. Alternatively spliced transcript variants
that encode different proteins have been described for this gene. [provided by RefSeq]

UniProtKB/Swiss-Prot: MRP6_HUMAN, O95255
Function: May participate directly in the active transport of drugs into subcellular organelles or
influence drug distribution indirectly. Transports glutathione conjugates as leukotriene-c4 (LTC4)
and N-ethylmaleimide S-glutathione (NEM-GS)

Gene Wiki entry for ABCC6

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the ABCC6 gene  

Entrez Gene cytogenetic band: 16p13.1   Ensembl cytogenetic band:  16p13.11   HGNC cytogenetic band: 16p13.1

ABCC6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M016151:     (about GC identifiers)

Start:
16,150,923 bp from pter
End:
16,224,838 bp from pter
Size:
73,916 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000016.8  NT_010393.15  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: MRP6_HUMAN, O95255 (See protein sequence)
Recommended Name: Multidrug resistance-associated protein 6  
Size: 1503 amino acids; 164904 Da
Subcellular location: Membrane; Multi-pass membrane protein (By similarity)
Sequence caution: Sequence=AAC15785.1; Type=Erroneous gene model prediction;
Secondary accessions: P78420 Q9UMZ7

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins (2 alternative transcripts): 
    NP_001072996.1  NP_001162.4  


    ENSEMBL proteins: 
    ENSP00000205558 ENSP00000205557 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Sigma-Aldrich CompoZr ZFN for ABCC6  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (MRP6)
    Human Recombinant Proteins from Abnova (ABCC6)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    2 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886 plasma membrane TAS10835642
    GO:0016021 integral to membrane IEA--
    About this table

    Antibodies for ABCC6: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for ABCC6
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (MRP6), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (ABCC6)
    Novus Biologicals Antibodies for ABCC6

    Assays for ABCC6: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    5/6 InterPro domains/families (see all 6 ):
     IPR003593 ATPase_AAA+_core
     IPR003439 ABC_transporter-like
     IPR017940 ABC_transporter_type1
     IPR005292 Multidrug-R_assoc_MRP
     IPR001140 ABC_TM_transpt


       GeneDecks  ABCC6 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry O95255

    ProtoNet protein and cluster: O95255

    UniProtKB/Swiss-Prot: MRP6_HUMAN, O95255
    Similarity: Belongs to the ABC transporter family. Conjugate transporter (TC 3.A.1.208) subfamily
    Similarity: Contains 2 ABC transmembrane type-1 domains
    Similarity: Contains 2 ABC transporter domains

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (ABCC6)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (ABCC6)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001079528

                  Applied Biosystems Silencer® siRNAs for ABCC6

                  Sigma-Aldrich siRNA and siRNA Panels for ABCC6  
                         Sigma-Aldrich shRNA Panels and shRNA for ABCC6  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for ABCC6
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001079528
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001079528
                                     untagged cDNA clones in CMV expression vector (see all 3): NM_001079528 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_001171

    UniProtKB/Swiss-Prot: MRP6_HUMAN, O95255
    Function: May participate directly in the active transport of drugs into subcellular organelles or
    influence drug distribution indirectly. Transports glutathione conjugates as leukotriene-c4 (LTC4)
    and N-ethylmaleimide S-glutathione (NEM-GS)

    Genatlas biochemistry entry for ABCC6:
    ATP binding cassette superfamily,subfamily C (CFTR/MRP),member 6,expressed in normal hematopoietic
    precursors

    7 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Abcc6):

    homeostasis/metabolismotherrenal/urinary systemskin/coat/nails
    touch/vibrissaevision/eye

    5 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166 nucleotide binding IEA--
    GO:0005215 transporter activity TAS8912525
    GO:0005524 ATP binding TAS8912525
    GO:0016887 ATPase activity IEA--
    GO:0042626 ATPase activity, coupled to transmembrane movement of substances TAS8912525
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


    1 Sigma-Aldrich "Your Favorite Gene" Pathway for  ABCC6  (Your Favorite Gene powered by Ingenuity) 
     Purine Metabolism

       GeneDecks  ABCC6 for the pathways selected above  
    About GeneDecksing

    1 Kegg Pathway  (Kegg details for ABCC6):
     hsa02010 ABC transporters

       GeneDecks  ABCC6 for the pathways selected above  
    About GeneDecksing
     Gene Network CentralTM Interacting Genes and Proteins Network for  ABCC6 


    3 Interacting proteins for ABCC6 (ENSP000002055573) via UniProtKB, MINT, and/or STRING
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MRPS7ENSP000002455393STRING (score=.795)
    IGKV3D-15ENSP000003748093STRING (score=.748)
    CD79AENSP000002219723STRING (score=.706)
    About this table

    4 Gene Ontology (GO) biological process terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810 transport TAS8912525
    GO:0007601 visual perception IEA--
    GO:0042493 response to drug TAS8912525
    GO:0050896 response to stimulus IEA--
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for ABCC6
    3 Novoseek chemical compound relationships for ABCC6 gene
    Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    atp 22.16 15 15894595 (2), 11880368 (2), 10913334 (1), 17617515 (1) (see all 5)
    lipid 0.00 1 16835894 (1)
    agarose 0.00 1 15727254 (1)
    About this table


    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (ABCC6)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (ABCC6)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001079528

                  Sigma-Aldrich siRNA and siRNA Panels for ABCC6  
                         Sigma-Aldrich shRNA Panels and shRNA for ABCC6  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_001079528  NM_001171  

    REFSEQ mRNAs for ABCC6 gene (2 alternative transcripts): 

    NM_001079528.3   NM_001171.5   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_001079528  NM_001171  

                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001079528
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001079528
                                     untagged cDNA clones in CMV expression vector (see all 3): NM_001079528 

    Additional cDNA sequence: 

    AF076622.1 AF168791.1 AK298295.1 AM774324.1 AY078405.1 BC050733.1 BC131732.1 CR609146.1 
    U66689.1 

    6 DOTS entries:

    DT.112058  DT.100748629  DT.100836282  DT.97770455  DT.100889165  DT.453296 

    14 AceView cDNA sequences:

    AI830055 AI631807 BX283084 R99091 BI830076 AW235625 BV203038 BC015978 
    BF334136 R99635 BQ181437 AI935444 BF105026 H94400 

    highest scoring ESTs for ABCC6:

    AF076622 AF168791 AL596779 BC050733 BU187020 H49232 H49806 N95104 R97754 U66689 

    Unigene Cluster for ABCC6:

    ATP-binding cassette, sub-family C (CFTR/MRP), member 6
    Hs.442182  [show with all ESTs]
    Unigene Representative Sequence: NM_001171


    GeneLoc Exon Structure

    2 Ensembl transcripts including schematic representations:
    ENST00000205558  ENST00000205557  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    ABCC6 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for ABCC6

    1 / 2 / 3

    8 probe-sets matching ABCC6 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    964_at2, 3 U95-A 2 1.00 0.97 0.77 1.22 X95715 0.60 1.00 0.82 1
    39247_at2, 3 U95-A 2 1.00 0.50 0.96 0.86 U66689 1.00 0.80 0.91 1

    208480_s_at2, 3 U133-A 1 1.00 1.00 -- -- NM_001171 0.60 1.00 0.82 1

    215559_at2, 3 U133-A 1 1.00 1.00 -- -- AI074459 0.40 1.00 0.76 1

    214033_at2, 3 U133-A 2 1.00 0.55 -- -- AI084637 0.60 1.00 0.82 1

    208480_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    215559_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    214033_at2 U133Plus2 2 1.00 0.55 -- -- -- -- -- -- --
    GeneDecks  ABCC6 for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: TAGACTCTTG

    SOURCE GeneReport for Unigene cluster: Hs.442182

    Expression variation in blood from EXPOLDB for ABCC6

    UniProtKB/Swiss-Prot: MRP6_HUMAN, O95255
    Tissue specificity: Expressed in kidney and liver. Very low expression in other tissues

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for ABCC6 gene from 5 species
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    ABCC61   -- ATP-binding cassette, sub-family C (CFTR/MRP), member more 83.43(n)
    79.57(a)
    489993  XM_547113.2  XP_547113.2 
    rat
    (Rattus norvegicus)
    Abcc61   -- ATP-binding cassette, sub-family C (CFTR/MRP), member more 80.82(n)
    79.61(a)
    81642  NM_031013.1  NP_112275.1 
    mouse
    (Mus musculus)
    Abcc61, 5 7 (24.50 cM)5
    ATP-binding cassette, sub-family C (CFTR/MRP), member more1, 5 80.95(n)1
    79.62(a)1
    274211  NM_018795.11  NP_061265.11 
     AB0287375  BC0404005  (see all 9)
    chicken
    (Gallus gallus)
    ABCC61   -- ATP-binding cassette, sub-family C (CFTR/MRP), member more 59.94(n)
    54.72(a)
    416600  XM_001234743.1  XP_001234744.1 
    worm
    (Caenorhabditis elegans)
    C18C4.23 V(5541395-5548247) trans-membrane protein 23(a)   --
    About this table        Species with no ortholog for ABCC6

    ENSEMBL Gene Tree for ABCC6
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for ABCC6 gene
    ABCC32  ABCC12  ABCC22  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/817 NCBI SNPs in ABCC6 are shown (see all 817 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 141)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 16 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs22384721,2
    A,C,F,H,O16159100(-) GTTCCG/AGGACT 1 Q/R mis116Minor allele frequency- A:0.14EA NA EU WA 1414
    rs80586941,2
    A,C,F,H16186364(+) GCACTG/TTGTAT 1 H/Q mis1 ese312Minor allele frequency- T:0.22EU EA WA NA 1192
    rs129314721,2
    A,C,F,H16188508(+) CTACGA/GCACCA 1 V/A mis112Minor allele frequency- N:0.00EA NA EU WA 1056
    rs64166681,2
    A,C,F,H16178858(+) ACACAC/TGAGGG 1 V/M mis1 ese311Minor allele frequency- T:0.02EU EA WA NA 978
    rs39024011,2
    A,C,F16151474(+) GGGTAC/TGGTTG 1 -- ut316Minor allele frequency- T:0.07EA NA MN 662
    --
    rs2120961,2
    A,C16151176(+) ctagcC/Tgggag 1 -- ut310--------
    rs43417701,2
    C,H16184238(+) CCCCCA/GCTGGA 1 V/A mis1 ese34Minor allele frequency- G:0.00EU EA WA 406
    --
    rs412781741,2
    C16167097(+) GGACCA/GGAGTT 1 R/W mis10--------
    --
    rs118619801,2
    H16174734(+) GGTACG/CGTCCT 1 G/R mis1 ese34Minor allele frequency- C:0.00EU EA WA 416
    --
    rs99308861,2
    A,C,F,H16199484(+) ACCAGA/GTTGAC 1 N/N syn14Minor allele frequency- G:0.30EU EA WA 408
    About this table

    HapMap Linkage Disequilibrium images for ABCC6 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 603234   disorders: 264800  177850  

    UniProtKB/Swiss-Prot: MRP6_HUMAN, O95255

  • Defects in ABCC6 are the cause of pseudoxanthoma elasticum (PXE) [MIM:264800]. PXE is a
    disorder characterized by calcification of elastic fibers in skin, arteries and retina that
    results in dermal lesions with associated laxity and loss of elasticity, arterial insufficiency
    and retinal hemorrhages leading to macular degeneration. PXE is caused in the overwhelming
    majority of cases by homozygous or compound heterozygous mutations in the ABCC6 gene (autosomal
    recessive PXE). Individuals carrying heterozygous mutations express limited manifestations of the
    pseudoxanthoma elasticum phenotype (autosomal dominant PXE)
  • 10/14 Novoseek disease relationships for ABCC6 gene (see all 14 )

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    pseudoxanthoma elasticum 98.70 90 11536079 (2), 15459974 (2), 16604369 (2), 11439001 (2) (see all 63)
    angioid streaks 89.30 5 19284998 (1), 17134037 (1), 12271376 (1), 14694786 (1)
    heritable connective tissue disorder 89.12 3 15086542 (1), 16571645 (1), 16374464 (1)
    genetic disorder 71.26 7 15459974 (1), 15760889 (1), 12810839 (1), 11702217 (1) (see all 6)
    calcification 66.59 14 18469514 (1), 16763870 (1), 16543900 (1), 16261549 (1) (see all 10)
    connective tissue diseases 48.09 3 14667841 (1), 19341707 (1)
    metabolic disorder 44.69 6 18469514 (1), 17134037 (1), 11493310 (1), 15894595 (1) (see all 5)
    choroidal neovascularization 23.88 1 17134037 (1)
    coronary artery disease 0.19 4 12176944 (2), 14631379 (1), 16854481 (1)
    cancer 0.00 1 9892204 (1)
    About this table

    GeneTests: ABCC6
    Pseudoxanthoma Elasticum

    Human Gene Mutation Database: ABCC6
    Genetic Association Database: ABCC6
    Human Genome Epidemiology Navigator: ABCC6 (13 documents)

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/144 PubMed articles for ABCC6 gene (see all 144 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 368 HGNC: 57 AceView: ABCC6.1 Ensembl:ENSG00000091262 euGenes: HUgn368
    ECgene: ABCC6 H-InvDB: ABCC6
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

    NameDescription
    ATLAS Chromosomes in Cancer entry for ABCC6 Genetics and Cytogenetics in Oncology and Haematology
    Mutations of the ABCC6 genehttp://www.retina-international.com/sci-news/abcc6mut.htm
    GeneReviewshttp://www.genetests.org/query?gene=ABCC6
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for ABCC6:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
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     Predesigned and custom siRNAs for ABCC6 Antibodies for ABCC6
     Explore super-pooled esiRNAs Proteins for ABCC6
     Lentivirus-delivered shRNAs for ABCC6 Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
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     Antibodies for ABCC6

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