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Aliases for ABCC5 Gene

Aliases for ABCC5 Gene

  • ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 5 2 3
  • Multi-Specific Organic Anion Transporter C 3 4
  • ATP-Binding Cassette Sub-Family C Member 5 3 4
  • MOAT-C 3 4
  • PABC11 3 4
  • SMRP 3 4
  • MRP5 3 4
  • Canalicular Multispecific Organic Anion Transporter C 3
  • EST277145 3
  • ABC33 3
  • MOATC 3

External Ids for ABCC5 Gene

Previous GeneCards Identifiers for ABCC5 Gene

  • GC03M180375
  • GC03M184632
  • GC03M185039
  • GC03M184958
  • GC03M185120
  • GC03M183637
  • GC03M181047

Summaries for ABCC5 Gene

Entrez Gene Summary for ABCC5 Gene

  • The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that this protein provides resistance to thiopurine anticancer drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. This protein may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside analogs in HIV-infected patients. Alternative splicing of this gene has been detected; however, the complete sequence and translation initiation site is unclear. [provided by RefSeq, Jul 2008]

GeneCards Summary for ABCC5 Gene

ABCC5 (ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 5) is a Protein Coding gene. Diseases associated with ABCC5 include lymphoblastic leukemia. Among its related pathways are Metabolism and Glycosaminoglycan metabolism. GO annotations related to this gene include ATPase activity and organic anion transmembrane transporter activity. An important paralog of this gene is ABCC9.

UniProtKB/Swiss-Prot for ABCC5 Gene

  • Acts as a multispecific organic anion pump which can transport nucleotide analogs.

Gene Wiki entry for ABCC5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ABCC5 Gene

Genomics for ABCC5 Gene

Regulatory Elements for ABCC5 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ABCC5 Gene

Chromosome:
3
Start:
183,919,934 bp from pter
End:
184,018,015 bp from pter
Size:
98,082 bases
Orientation:
Minus strand

Genomic View for ABCC5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ABCC5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ABCC5 Gene

Proteins for ABCC5 Gene

  • Protein details for ABCC5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15440-MRP5_HUMAN
    Recommended name:
    Multidrug resistance-associated protein 5
    Protein Accession:
    O15440
    Secondary Accessions:
    • B9EIQ2
    • O14517
    • Q29ZA9
    • Q29ZB1
    • Q86UX3
    • Q86W30
    • Q9UN85
    • Q9UNP5
    • Q9UQC3

    Protein attributes for ABCC5 Gene

    Size:
    1437 amino acids
    Molecular mass:
    160660 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ABCC5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ABCC5 Gene

Proteomics data for ABCC5 Gene at MOPED

Post-translational modifications for ABCC5 Gene

  • Ubiquitination at Lys 383
  • Glycosylation at Asn 494, Asn 636, Asn 684, Asn 890, Asn 897, Asn 1044, Asn 1329, and Asn 1417
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for ABCC5 Gene

Domains & Families for ABCC5 Gene

Gene Families for ABCC5 Gene

Protein Domains for ABCC5 Gene

Suggested Antigen Peptide Sequences for ABCC5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O15440

UniProtKB/Swiss-Prot:

MRP5_HUMAN :
  • Contains 2 ABC transmembrane type-1 domains.
  • Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
Domain:
  • Contains 2 ABC transmembrane type-1 domains.
  • Contains 2 ABC transporter domains.
Family:
  • Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
genes like me logo Genes that share domains with ABCC5: view

Function for ABCC5 Gene

Molecular function for ABCC5 Gene

GENATLAS Biochemistry:
ATP binding cassettte superfamily,subfamily C (CFTR/MRP),member 5
UniProtKB/Swiss-Prot Function:
Acts as a multispecific organic anion pump which can transport nucleotide analogs.

Gene Ontology (GO) - Molecular Function for ABCC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
GO:0008514 organic anion transmembrane transporter activity IEA --
GO:0016887 ATPase activity --
GO:0042626 ATPase activity, coupled to transmembrane movement of substances IEA --
genes like me logo Genes that share ontologies with ABCC5: view

Phenotypes for ABCC5 Gene

MGI mutant phenotypes for ABCC5:
inferred from 1 alleles
GenomeRNAi human phenotypes for ABCC5:
genes like me logo Genes that share phenotypes with ABCC5: view

Animal Models for ABCC5 Gene

MGI Knock Outs for ABCC5:

Animal Model Products

CRISPR Products

miRNA for ABCC5 Gene

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ABCC5

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for ABCC5 Gene

Localization for ABCC5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ABCC5 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ABCC5 Gene COMPARTMENTS Subcellular localization image for ABCC5 gene
Compartment Confidence
plasma membrane 4
extracellular 1

Gene Ontology (GO) - Cellular Components for ABCC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 9827529
GO:0016020 membrane IDA 15297306
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with ABCC5: view

Pathways & Interactions for ABCC5 Gene

genes like me logo Genes that share pathways with ABCC5: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for ABCC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process TAS --
GO:0006810 transport TAS 9827529
GO:0015711 organic anion transport IEA --
GO:0030203 glycosaminoglycan metabolic process TAS --
GO:0030212 hyaluronan metabolic process TAS --
genes like me logo Genes that share ontologies with ABCC5: view

No data available for SIGNOR curated interactions for ABCC5 Gene

Drugs & Compounds for ABCC5 Gene

(26) Drugs for ABCC5 Gene - From: NovoSeek, HMDB, DrugBank, and PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cisplatin Approved Pharma Transporter, inducer Inhibits DNA synthesis,chemotherapy drug, Platinum, Potent pro-apoptotic anticancer agent; activates caspase-3 2437
Probenecid Approved Pharma Activator, Transporter, inhibitor 27
Fluorouracil Approved Pharma Transporter, substrate RNA processing inhibitor and thymidylate synthase inhibitor 1937
Adefovir Dipivoxil Approved, Investigational Pharma Transporter, substrate 128
Dipyridamole Approved Pharma Inhibition, Inhibitor, Transporter, inhibitor Adenosine transport inhibitor 75

(9) Additional Compounds for ABCC5 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
5fluorouracil
6 mercaptopurine
6 thioguanine
Adriamycin
MK 571
genes like me logo Genes that share compounds with ABCC5: view

Transcripts for ABCC5 Gene

Unigene Clusters for ABCC5 Gene

ATP-binding cassette, sub-family C (CFTR/MRP), member 5:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ABCC5

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ABCC5 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15a · 15b · 15c ^ 16a · 16b ^ 17 ^ 18 ^
SP1: - - - - - -
SP2: - - - - - -
SP3: -
SP4: - -
SP5: -
SP6: -
SP7:

ExUns: 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34a · 34b
SP1:
SP2: -
SP3:
SP4:
SP5:
SP6:
SP7:

Relevant External Links for ABCC5 Gene

GeneLoc Exon Structure for
ABCC5
ECgene alternative splicing isoforms for
ABCC5

Expression for ABCC5 Gene

mRNA expression in normal human tissues for ABCC5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ABCC5 Gene

This gene is overexpressed in Muscle - Skeletal (x4.8).

Protein differential expression in normal tissues from HIPED for ABCC5 Gene

This gene is overexpressed in Lung (59.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ABCC5 Gene



SOURCE GeneReport for Unigene cluster for ABCC5 Gene Hs.743953

mRNA Expression by UniProt/SwissProt for ABCC5 Gene

O15440-MRP5_HUMAN
Tissue specificity: All isoforms are equally expressed in retina.
genes like me logo Genes that share expression patterns with ABCC5: view

Protein tissue co-expression partners for ABCC5 Gene

Primer Products

In Situ Assay Products

Orthologs for ABCC5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ABCC5 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia ABCC5 35
  • 92.6 (n)
  • 96.31 (a)
ABCC5 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Abcc5 35
  • 88.83 (n)
  • 95.06 (a)
Abcc5 16
Abcc5 36
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Abcc5 35
  • 88.23 (n)
  • 94.85 (a)
cow
(Bos Taurus)
Mammalia ABCC5 36
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ABCC5 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ABCC5 36
  • 91 (a)
OneToOne
chicken
(Gallus gallus)
Aves ABCC5 35
  • 79.75 (n)
  • 89.12 (a)
lizard
(Anolis carolinensis)
Reptilia ABCC5 36
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101732220 35
  • 73.67 (n)
  • 84.25 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC68608 35
zebrafish
(Danio rerio)
Actinopterygii abcc5 35
  • 68.8 (n)
  • 73.91 (a)
abcc5 36
  • 74 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG7806 37
  • 29 (a)
Sur 37
  • 42 (a)
Sur 36
  • 18 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea mrp-5 35
  • 48.41 (n)
  • 39 (a)
rice
(Oryza sativa)
Liliopsida Os02g0288400 35
  • 45.77 (n)
  • 37.22 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 45 (a)
OneToMany
Species with no ortholog for ABCC5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ABCC5 Gene

ENSEMBL:
Gene Tree for ABCC5 (if available)
TreeFam:
Gene Tree for ABCC5 (if available)

Paralogs for ABCC5 Gene

Paralogs for ABCC5 Gene

genes like me logo Genes that share paralogs with ABCC5: view

Variants for ABCC5 Gene

Sequence variations from dbSNP and Humsavar for ABCC5 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs562 -- 183,920,057(+) TTCAA(C/T)TGATG utr-variant-3-prime
rs3779 -- 183,983,782(+) AAATG(A/G)AAAAT utr-variant-3-prime, intron-variant
rs869335 -- 183,972,455(-) CTCTG(C/T)GGTAG intron-variant
rs869417 -- 183,971,350(-) TGATC(A/G)TTTTA intron-variant
rs939336 -- 183,967,746(+) CTGCC(A/G)CAGAT synonymous-codon, reference

Structural Variations from Database of Genomic Variants (DGV) for ABCC5 Gene

Variant ID Type Subtype PubMed ID
nsv520094 CNV Loss 19592680
nsv878050 CNV Loss 21882294
esv25219 CNV Loss 19812545
esv1002813 CNV Loss 20482838
esv2726293 CNV Deletion 23290073
esv2678542 CNV Deletion 23128226
esv2726294 CNV Deletion 23290073
dgv5353n71 CNV Loss 21882294

Variation tolerance for ABCC5 Gene

Residual Variation Intolerance Score: .5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.90; 35.42% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ABCC5 Gene

HapMap Linkage Disequilibrium report
ABCC5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ABCC5 Gene

Disorders for ABCC5 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ABCC5 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
lymphoblastic leukemia
  • acute lymphocytic leukemia
- elite association
Search ABCC5 in MalaCards View complete list of genes associated with diseases

Relevant External Links for ABCC5

Genetic Association Database (GAD)
ABCC5
Human Genome Epidemiology (HuGE) Navigator
ABCC5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ABCC5
genes like me logo Genes that share disorders with ABCC5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ABCC5 Gene

Publications for ABCC5 Gene

  1. Characterization of the transport of nucleoside analog drugs by the human multidrug resistance proteins MRP4 and MRP5. (PMID: 12695538) Reid G. … Borst P. (Mol. Pharmacol. 2003) 23 25 26 67
  2. Multidrug-resistance protein 5 is a multispecific organic anion transporter able to transport nucleotide analogs. (PMID: 10840050) Wijnholds J. … Borst P. (Proc. Natl. Acad. Sci. U.S.A. 2000) 23 25 26 67
  3. The multidrug resistance protein 5 functions as an ATP-dependent export pump for cyclic nucleotides. (PMID: 10893247) Jedlitschky G. … Keppler D. (J. Biol. Chem. 2000) 23 25 26 67
  4. Human skeletal muscle drug transporters determine local exposure and toxicity of statins. (PMID: 19940267) Knauer M.J. … Tirona R.G. (Circ. Res. 2010) 23 25 67
  5. ATP-binding cassette C transporters in human pancreatic carcinoma cell lines. Upregulation in 5-fluorouracil-resistant cells. (PMID: 19077464) Hagmann W. … LAPhr J.M. (Pancreatology 2009) 23 25 67

Products for ABCC5 Gene

Sources for ABCC5 Gene

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