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Aliases for ABCC5 Gene

Aliases for ABCC5 Gene

  • ATP Binding Cassette Subfamily C Member 5 2 3 5
  • ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 5 2 3
  • Multi-Specific Organic Anion Transporter C 3 4
  • ATP-Binding Cassette Sub-Family C Member 5 3 4
  • MOAT-C 3 4
  • PABC11 3 4
  • MRP5 3 4
  • SMRP 3 4
  • Canalicular Multispecific Organic Anion Transporter C 3
  • EST277145 3
  • ABC33 3
  • MOATC 3

External Ids for ABCC5 Gene

Previous GeneCards Identifiers for ABCC5 Gene

  • GC03M180375
  • GC03M184632
  • GC03M185039
  • GC03M184958
  • GC03M185120
  • GC03M183637
  • GC03M181047

Summaries for ABCC5 Gene

Entrez Gene Summary for ABCC5 Gene

  • The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that this protein provides resistance to thiopurine anticancer drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. This protein may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside analogs in HIV-infected patients. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

GeneCards Summary for ABCC5 Gene

ABCC5 (ATP Binding Cassette Subfamily C Member 5) is a Protein Coding gene. Diseases associated with ABCC5 include lymphoblastic leukemia. Among its related pathways are Metabolism and Glycosaminoglycan metabolism. GO annotations related to this gene include ATPase activity and organic anion transmembrane transporter activity. An important paralog of this gene is ABCC12.

UniProtKB/Swiss-Prot for ABCC5 Gene

  • Acts as a multispecific organic anion pump which can transport nucleotide analogs.

Gene Wiki entry for ABCC5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ABCC5 Gene

Genomics for ABCC5 Gene

Regulatory Elements for ABCC5 Gene

Promoters for ABCC5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ABCC5 on UCSC Golden Path with GeneCards custom track

Genomic Location for ABCC5 Gene

Chromosome:
3
Start:
183,919,934 bp from pter
End:
184,018,015 bp from pter
Size:
98,082 bases
Orientation:
Minus strand

Genomic View for ABCC5 Gene

Genes around ABCC5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ABCC5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ABCC5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ABCC5 Gene

Proteins for ABCC5 Gene

  • Protein details for ABCC5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15440-MRP5_HUMAN
    Recommended name:
    Multidrug resistance-associated protein 5
    Protein Accession:
    O15440
    Secondary Accessions:
    • B9EIQ2
    • O14517
    • Q29ZA9
    • Q29ZB1
    • Q86UX3
    • Q86W30
    • Q9UN85
    • Q9UNP5
    • Q9UQC3

    Protein attributes for ABCC5 Gene

    Size:
    1437 amino acids
    Molecular mass:
    160660 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ABCC5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ABCC5 Gene

Proteomics data for ABCC5 Gene at MOPED

Post-translational modifications for ABCC5 Gene

  • Ubiquitination at Lys 383
  • Glycosylation at Asn 494, Asn 636, Asn 684, Asn 890, Asn 897, Asn 1044, Asn 1329, and Asn 1417
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for ABCC5 Gene

Domains & Families for ABCC5 Gene

Gene Families for ABCC5 Gene

Protein Domains for ABCC5 Gene

Suggested Antigen Peptide Sequences for ABCC5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O15440

UniProtKB/Swiss-Prot:

MRP5_HUMAN :
  • Contains 2 ABC transmembrane type-1 domains.
  • Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
Domain:
  • Contains 2 ABC transmembrane type-1 domains.
  • Contains 2 ABC transporter domains.
Family:
  • Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
genes like me logo Genes that share domains with ABCC5: view

Function for ABCC5 Gene

Molecular function for ABCC5 Gene

GENATLAS Biochemistry:
ATP binding cassettte superfamily,subfamily C (CFTR/MRP),member 5
UniProtKB/Swiss-Prot Function:
Acts as a multispecific organic anion pump which can transport nucleotide analogs.

Gene Ontology (GO) - Molecular Function for ABCC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042626 ATPase activity, coupled to transmembrane movement of substances IEA --
genes like me logo Genes that share ontologies with ABCC5: view
genes like me logo Genes that share phenotypes with ABCC5: view

Animal Models for ABCC5 Gene

MGI Knock Outs for ABCC5:

Animal Model Products

CRISPR Products

miRNA for ABCC5 Gene

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ABCC5 Gene

Localization for ABCC5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ABCC5 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ABCC5 Gene COMPARTMENTS Subcellular localization image for ABCC5 gene
Compartment Confidence
plasma membrane 5
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ABCC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IDA 15297306
genes like me logo Genes that share ontologies with ABCC5: view

Pathways & Interactions for ABCC5 Gene

genes like me logo Genes that share pathways with ABCC5: view

Gene Ontology (GO) - Biological Process for ABCC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA,TAS 9827529
GO:0030213 hyaluronan biosynthetic process TAS --
GO:0055085 transmembrane transport IEA,TAS --
genes like me logo Genes that share ontologies with ABCC5: view

No data available for SIGNOR curated interactions for ABCC5 Gene

Drugs & Compounds for ABCC5 Gene

(26) Drugs for ABCC5 Gene - From: Novoseek, PharmGKB, DrugBank, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cisplatin Approved Pharma Transporter, inducer Inhibits DNA synthesis,chemotherapy drug, Platinum 2540
Probenecid Approved Pharma Inhibition, Inhibitor, Transporter, inhibitor 27
Fluorouracil Approved Pharma Transporter, substrate RNA processing inhibitor and thymidylate synthase inhibitor 1684
Adefovir Dipivoxil Approved, Investigational Pharma Transporter, substrate 130
Dipyridamole Approved Pharma Inhibition, Inhibitor, Transporter, inhibitor Adenosine transport inhibitor 76

(9) Additional Compounds for ABCC5 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ABCC5: view

Transcripts for ABCC5 Gene

Unigene Clusters for ABCC5 Gene

ATP-binding cassette, sub-family C (CFTR/MRP), member 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ABCC5 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15a · 15b · 15c ^ 16a · 16b ^ 17 ^ 18 ^
SP1: - - - - - -
SP2: - - - - - -
SP3: -
SP4: - -
SP5: -
SP6: -
SP7:

ExUns: 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34a · 34b
SP1:
SP2: -
SP3:
SP4:
SP5:
SP6:
SP7:

Relevant External Links for ABCC5 Gene

GeneLoc Exon Structure for
ABCC5
ECgene alternative splicing isoforms for
ABCC5

Expression for ABCC5 Gene

mRNA expression in normal human tissues for ABCC5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ABCC5 Gene

This gene is overexpressed in Muscle - Skeletal (x4.8).

Protein differential expression in normal tissues from HIPED for ABCC5 Gene

This gene is overexpressed in Lung (59.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ABCC5 Gene



SOURCE GeneReport for Unigene cluster for ABCC5 Gene Hs.743953

mRNA Expression by UniProt/SwissProt for ABCC5 Gene

O15440-MRP5_HUMAN
Tissue specificity: All isoforms are equally expressed in retina.
genes like me logo Genes that share expression patterns with ABCC5: view

Protein tissue co-expression partners for ABCC5 Gene

Primer Products

In Situ Assay Products

Orthologs for ABCC5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ABCC5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ABCC5 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ABCC5 36
  • 96 (a)
OneToOne
ABCC5 35
  • 92.6 (n)
  • 96.31 (a)
mouse
(Mus musculus)
Mammalia Abcc5 36
  • 95 (a)
OneToOne
Abcc5 16
Abcc5 35
  • 88.83 (n)
  • 95.06 (a)
oppossum
(Monodelphis domestica)
Mammalia ABCC5 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ABCC5 36
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Abcc5 35
  • 88.23 (n)
  • 94.85 (a)
chicken
(Gallus gallus)
Aves ABCC5 35
  • 79.75 (n)
  • 89.12 (a)
lizard
(Anolis carolinensis)
Reptilia ABCC5 36
  • 85 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC68608 35
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101732220 35
  • 73.67 (n)
  • 84.25 (a)
zebrafish
(Danio rerio)
Actinopterygii abcc5 36
  • 74 (a)
OneToOne
abcc5 35
  • 68.8 (n)
  • 73.91 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7806 37
  • 29 (a)
Sur 37
  • 42 (a)
Sur 36
  • 18 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea mrp-5 35
  • 48.41 (n)
  • 39 (a)
rice
(Oryza sativa)
Liliopsida Os02g0288400 35
  • 45.77 (n)
  • 37.22 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 45 (a)
OneToMany
Species with no ortholog for ABCC5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ABCC5 Gene

ENSEMBL:
Gene Tree for ABCC5 (if available)
TreeFam:
Gene Tree for ABCC5 (if available)

Paralogs for ABCC5 Gene

Paralogs for ABCC5 Gene

genes like me logo Genes that share paralogs with ABCC5: view

Variants for ABCC5 Gene

Sequence variations from dbSNP and Humsavar for ABCC5 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1132776 -- 183,978,614(-) AAAGC(C/T)GGGTA reference, synonymous-codon, utr-variant-5-prime
rs1016752 -- 183,947,274(-) TTCCT(C/G)TGCTG intron-variant
rs2139559 -- 183,936,149(-) GCCCG(A/C/T)GGAAA intron-variant
rs2139560 -- 183,936,081(-) taatc(C/T)cctcc intron-variant
rs2139561 -- 183,935,466(-) GCGGT(A/G)GCTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ABCC5 Gene

Variant ID Type Subtype PubMed ID
nsv520094 CNV Loss 19592680
nsv878050 CNV Loss 21882294
esv25219 CNV Loss 19812545
esv1002813 CNV Loss 20482838
esv2726293 CNV Deletion 23290073
esv2678542 CNV Deletion 23128226
esv2726294 CNV Deletion 23290073
dgv5353n71 CNV Loss 21882294

Variation tolerance for ABCC5 Gene

Residual Variation Intolerance Score: 0.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.90; 35.42% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ABCC5 Gene

HapMap Linkage Disequilibrium report
ABCC5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ABCC5 Gene

Disorders for ABCC5 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ABCC5 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
lymphoblastic leukemia
  • leukemia, lymphoid
- elite association - COSMIC cancer census association via MalaCards
Search ABCC5 in MalaCards View complete list of genes associated with diseases

Relevant External Links for ABCC5

Genetic Association Database (GAD)
ABCC5
Human Genome Epidemiology (HuGE) Navigator
ABCC5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ABCC5
genes like me logo Genes that share disorders with ABCC5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ABCC5 Gene

Publications for ABCC5 Gene

  1. Characterization of MOAT-C and MOAT-D, new members of the MRP/cMOAT subfamily of transporter proteins. (PMID: 9827529) Belinsky M.G. … Kruh G.D. (J. Natl. Cancer Inst. 1998) 2 3 4 23 67
  2. Characterization of the transport of nucleoside analog drugs by the human multidrug resistance proteins MRP4 and MRP5. (PMID: 12695538) Reid G. … Borst P. (Mol. Pharmacol. 2003) 3 23 25 26
  3. Multidrug-resistance protein 5 is a multispecific organic anion transporter able to transport nucleotide analogs. (PMID: 10840050) Wijnholds J. … Borst P. (Proc. Natl. Acad. Sci. U.S.A. 2000) 3 23 25 26
  4. The multidrug resistance protein 5 functions as an ATP-dependent export pump for cyclic nucleotides. (PMID: 10893247) Jedlitschky G. … Keppler D. (J. Biol. Chem. 2000) 3 23 25 26
  5. Human skeletal muscle drug transporters determine local exposure and toxicity of statins. (PMID: 19940267) Knauer M.J. … Tirona R.G. (Circ. Res. 2010) 3 23 25

Products for ABCC5 Gene

Sources for ABCC5 Gene

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