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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ABCC5 Gene

protein-coding   GIFtS: 63
GCID: GC03M183637

ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 5

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 51 2     pABC112 3
MRP52 3 5     MOATC2 5
Multi-Specific Organic Anion Transporter C2 3     ABC332
MOAT-C2 3     EST2771452
SMRP2 3     Canalicular Multispecific Organic Anion Transporter C2
ATP-Binding Cassette Sub-Family C Member 52 3     Multidrug Resistance-Associated Protein 52

External Ids:    HGNC: 561   Entrez Gene: 100572   Ensembl: ENSG000001147707   OMIM: 6052515   UniProtKB: O154403   

Export aliases for ABCC5 gene to outside databases

Previous GC identifers: GC03M180375 GC03M184632 GC03M185039 GC03M184958 GC03M185120 GC03M181047


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ABCC5 Gene:
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC
proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven
distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily
which is involved in multi-drug resistance. This protein functions in the cellular export of its substrate,
cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination
pathway for cyclic nucleotides. Studies show that this protein provides resistance to thiopurine anticancer
drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. This protein
may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside
analogs in HIV-infected patients. Alternative splicing of this gene has been detected; however, the complete
sequence and translation initiation site is unclear. (provided by RefSeq, Jul 2008)

GeneCards Summary for ABCC5 Gene: 
ABCC5 (ATP-binding cassette, sub-family C (CFTR/MRP), member 5) is a protein-coding gene. Diseases associated with ABCC5 include lymphoblastic leukemia, and dysembryoplastic neuroepithelial tumor, and among its related super-pathways are ABC-family proteins mediated transport and Fluoropyrimidine Pathway, Pharmacokinetics. GO annotations related to this gene include ATPase activity, coupled to transmembrane movement of substances and organic anion transmembrane transporter activity. An important paralog of this gene is ABCC4.

UniProtKB/Swiss-Prot: MRP5_HUMAN, O15440
Function: Acts as a multispecific organic anion pump which can transport nucleotide analogs

Gene Wiki entry for ABCC5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NT_005612.16  NC_018914.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ABCC5 gene promoter:
         SRF   NF-1   SRF (504 AA)   POU6F1 (c2)   CUTL1   Tal-1beta   E47   FOXL1   AREB6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): ABCC5 promoter sequence
   Search SABiosciences Chromatin IP Primers for ABCC5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ABCC5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q27   Ensembl cytogenetic band:  3q27.1   HGNC cytogenetic band: 3q27

ABCC5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ABCC5 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M183637:  view genomic region     (about GC identifiers)

Start:
183,637,722 bp from pter      End:
183,735,803 bp from pter
Size:
98,082 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MRP5_HUMAN, O15440 (See protein sequence)
Recommended Name: Multidrug resistance-associated protein 5  
Size: 1437 amino acids; 160660 Da
Subcellular location: Membrane; Multi-pass membrane protein
Secondary accessions: B9EIQ2 O14517 Q29ZA9 Q29ZB1 Q86W30 Q9UN85 Q9UNP5 Q9UQC3
Alternative splicing: 4 isoforms:  O15440-1   O15440-2   O15440-3   O15440-4   (Predominant isoform in retinal pigment epithelium, bladder, and stomach)

Explore the universe of human proteins at neXtProt for ABCC5: NX_O15440

Explore proteomics data for ABCC5 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O15440

  • ABCC5 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ABCC5 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001018881.1  NP_005679.2  

    ENSEMBL proteins: 
     ENSP00000333926   ENSP00000403510   ENSP00000404302   ENSP00000404809   ENSP00000416840  
     ENSP00000376358   ENSP00000371934   ENSP00000409913   ENSP00000399726   ENSP00000390911  
     ENSP00000265586  
    Reactome Protein details: O15440
    Human Recombinant Protein Products for ABCC5: 
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    Novus Biologicals ABCC5 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ABCC5 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane TAS9827529
    GO:0016020membrane IDA15297306
    GO:0016021integral to membrane ----

    ABCC5 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ABCC: ATP binding cassette transporters / subfamily C

    IUPHAR Guide to PHARMACOLOGY protein family classification: ABCC5 
    ABCC subfamily

    5/7 InterPro protein domains (see all 7):
     IPR003439 ABC_transporter-like
     IPR027417 P-loop_NTPase
     IPR001140 ABC_transptr_TM_dom
     IPR003593 AAA+_ATPase
     IPR017940 ABC_transporter_type1

    Graphical View of Domain Structure for InterPro Entry O15440

    ProtoNet protein and cluster: O15440

    UniProtKB/Swiss-Prot: MRP5_HUMAN, O15440
    Similarity: Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208)
    subfamily
    Similarity: Contains 2 ABC transmembrane type-1 domains
    Similarity: Contains 2 ABC transporter domains


    ABCC5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MRP5_HUMAN, O15440
    Function: Acts as a multispecific organic anion pump which can transport nucleotide analogs

         Genatlas biochemistry entry for ABCC5:
    ATP binding cassettte superfamily,subfamily C (CFTR/MRP),member 5

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding ----
    GO:0005524ATP binding IEA--
    GO:0008514organic anion transmembrane transporter activity TAS9827529
    GO:0016887ATPase activity ----
    GO:0017111nucleoside-triphosphatase activity ----
         
    ABCC5 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Abcc5):
     cellular 

    ABCC5 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Abcc5tm1Bor for ABCC5

       inGenious Targeting Laboratory - Custom generated mouse model solutions for ABCC5 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ABCC5

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ABCC5 
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    8/21 QIAGEN miScript miRNA Assays for microRNAs that regulate ABCC5 (see all 21):
    hsa-miR-3607-3p hsa-let-7d hsa-miR-181c* hsa-miR-624* hsa-let-7a-2* hsa-let-7c hsa-miR-340 hsa-let-7g
    SwitchGear 3'UTR luciferase reporter plasmidABCC5 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ABCC5 About   (see all 11)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1ABC-family proteins mediated transport
    ABC-family proteins mediated transport0.70
    ABC transporters0.70
    2Fluoropyrimidine Activity
    Fluoropyrimidine Activity0.69
    Fluoropyrimidine Pathway, Pharmacokinetics0.69
    3MPS IIIC - Sanfilippo syndrome C
    MPS IIIC - Sanfilippo syndrome C0.48
    Glycosaminoglycan metabolism0.48
    MPS IV - Morquio syndrome A0.48
    MPS IIID - Sanfilippo syndrome D0.48
    MPS VI - Maroteaux-Lamy syndrome0.48
    MPS I - Hurler syndrome0.48
    MPS IV - Morquio syndrome B0.48
    MPS IX - Natowicz syndrome0.48
    4Hyaluronan uptake and degradation
    Hyaluronan metabolism0.71
    5SLC-mediated transmembrane transport
    Transmembrane transport of small molecules0.50

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for ABCC5
        Fluoropyrimidine Activity

    5/20        Reactome Pathways for ABCC5 (see all 20)
        Hyaluronan metabolism
    MPS VI - Maroteaux-Lamy syndrome
    Metabolism
    Disease
    Transmembrane transport of small molecules

    4 PharmGKB Pathways for ABCC5
        Acetaminophen Pathway, Pharmacokinetics
    Fluoropyrimidine Pathway, Pharmacokinetics
    Thiopurine Pathway, Pharmacokinetics/Pharmacodynamics
    Zidovudine Pathway, Pharmacokinetics/Pharmacodynamics

    1         Kegg Pathway  (Kegg details for ABCC5):
        ABC transporters


    ABCC5 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ABCC5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    5/8 Interacting proteins for ABCC5 (O154403 ENSP000003339264) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ESR1P033723, ENSP000002062494I2D: score=1 STRING: ENSP00000206249
    HAS1ENSP000002221154STRING: ENSP00000222115
    HAS3ENSP000003044404STRING: ENSP00000304440
    UBCENSP000003448184STRING: ENSP00000344818
    AK2ENSP000003469214STRING: ENSP00000346921
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process TAS--
    GO:0006810transport TAS9827529
    GO:0015711organic anion transport TAS9827529
    GO:0030203glycosaminoglycan metabolic process TAS--
    GO:0030212hyaluronan metabolic process TAS--

    ABCC5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ABCC5 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for ABCC5 (MRP5)

    10/15 DrugBank Compounds for ABCC5 (see all 15)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Sildenafil-- 139755-83-2transporterinhibitor12695538 10893247
    Adefovir DipivoxilAdefovir (see all 7)142340-99-6transportersubstrate10840050
    Alprostadil-- 745-65-3transporterinhibitor12835412
    Atorvastatin-- 134523-00-5transportersubstrate19940267
    CisplatinCDDP (see all 7)15663-27-1transporterinducer11323161
    Cyclic Adenosine Monophosphate3'-5'-cyclic adenosine monophosphate (see all 5)60-92-4transporterinhibitor10893247
    DinoprostoneDinoprostone Prostaglandin E2 (see all 3)363-24-6transporterinhibitor12835412
    DipyridamoleDipiridamol (see all 6)58-32-2transporterinhibitor12695538
    Fluorouracil5-Fluorouracil (see all 6)51-21-8transportersubstrate19077464
    Glutathione5-L-Glutamyl-L-cysteinylglycine (see all 5)70-18-8transportersubstrate16539673

    10/21 Novoseek inferred chemical compound relationships for ABCC5 gene (see all 21)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mk 571 80.5 3 16337112 (1), 12695538 (1)
    s-(2,4-dinitrophenyl)glutathione 80.4 2 10840050 (1)
    probenecid 71.2 1 16337112 (1)
    adefovir 64.7 8 19323627 (2), 10840050 (1), 12695538 (1), 16868766 (1)
    thiopurine 60.9 3 19340001 (1), 12435799 (1)
    6 thioguanine 57.7 1 12435799 (1)
    zaprinast 56.8 1 17540771 (1)
    nucleoside 56.7 11 12695538 (2), 10840050 (1), 15897250 (1), 15816546 (1) (see all 5)
    cgmp 54.8 24 11956491 (3), 14507663 (2), 16614078 (2), 17540771 (2) (see all 8)
    6 mercaptopurine 44.4 4 12435799 (4)

    Search CenterWatch for drugs/clinical trials and news about ABCC5 / MRP5

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ABCC5 gene (2 alternative transcripts): 
    NM_001023587.1  NM_005688.2  

    Unigene Cluster for ABCC5:

    ATP-binding cassette, sub-family C (CFTR/MRP), member 5
    Hs.743953  [show with all ESTs]
    Unigene Representative Sequence: AF146074
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000334444(uc010hxl.3 uc003fmg.3) ENST00000437205(uc011bqt.2)
    ENST00000443497 ENST00000476402 ENST00000492216 ENST00000427120(uc010hxo.3)
    ENST00000443376(uc010hxm.3) ENST00000392579(uc010hxn.3) ENST00000382494(uc003fmh.3)
    ENST00000438979 ENST00000437341 ENST00000446941(uc003fmi.3) ENST00000265586

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    Additional mRNA sequence: 

    AB005659.1 AB019002.1 AB209103.1 AB209454.1 AF104942.1 AF146074.1 AK090667.1 AL359600.1 
    AY196484.1 AY754874.1 AY754875.1 AY754876.1 BC050744.1 BC051358.1 BC140771.1 BC142670.1 
    BC142719.1 BC144495.1 BX647245.1 BX649032.1 U66687.1 U83661.2 

    15 DOTS entries:

    DT.91688348  DT.312745  DT.100804398  DT.97801613  DT.86857789  DT.120866548  DT.120866554  DT.91755905 
    DT.97847973  DT.455723  DT.100746639  DT.120866613  DT.406116  DT.97813740  DT.97813791 

    24/289 AceView cDNA sequences (see all 289):

    BC050744 BU676278 BI823511 AI682524 BE336596 BM310353 BM758433 BU184871 
    BM747688 CR590924 BQ898022 CF264868 BQ272598 AI124876 BU855794 BM857419 
    AI493704 AW135435 AI884349 BU152827 AI911655 CR619835 BI770139 T87404 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for ABCC5 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15a · 15b · 15c ^ 16a · 16b ^ 17 ^ 18 ^
    SP1:                                      -     -                       -     -                                         -                       -               
    SP2:                                      -     -                       -     -                                         -                       -               
    SP3:                                                                                                                                            -               
    SP4:                                      -     -                                                                                                               
    SP5:                                            -                                                                                                               

    ExUns: 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34a · 34b
    SP1:                                                                                                      
    SP2:                                            -                                                         
    SP3:                                                                                                      
    SP4:                                                                                                      
    SP5:                                                                                                      


    ECgene alternative splicing isoforms for ABCC5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ABCC5 expression in normal human tissues (normalized intensities)      ABCC5 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTGCTGAAC
    ABCC5 Expression
    About this image


    ABCC5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/10 selected tissues (see all 10) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
             brain/midbrain   
     
     Heart (Cardiovascular System)    fully expand to see all 2 entries
             heart/atrium   
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Granulocytes Peripheral Blood
             mouse/organ system/cardiovascular system   
     
     Limb (Muscoskeletal System)    fully expand to see all 2 entries
             limb/hindlimb   
     
     Eye (Sensory Organs)
             Retina

    See ABCC5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ABCC5

    SOURCE GeneReport for Unigene cluster: Hs.743953

    UniProtKB/Swiss-Prot: MRP5_HUMAN, O15440
    Tissue specificity: All isoforms are equally expressed in retina

        SABiosciences Expression via Pathway-Focused PCR Arrays including ABCC5: 
              Drug Transporters in human mouse rat
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ABCC5 gene from 8/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Abcc51 , 5 ATP-binding cassette, sub-family C (CFTR/MRP), member more1, 5 88.83(n)1
    95.06(a)1
      16 (12.41 cM)5
    274161  NM_013790.21  NP_038818.21 
     203313035 
    chicken
    (Gallus gallus)
    Aves ABCC51 ATP-binding cassette, sub-family C (CFTR/MRP), member more 79.75(n)
    89.12(a)
      424947  XM_422754.3  XP_422754.2 
    lizard
    (Anolis carolinensis)
    Reptilia ABCC56
    Uncharacterized protein
    85(a)
    1 ↔ 1
    GL343245.1(1716202-1776649)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC686082 hypothetical protein MGC68608 75.87(n)    BC060469.1 
    zebrafish
    (Danio rerio)
    Actinopterygii CK024774.12   -- 76.39(n)    CK024774.1 
    worm
    (Caenorhabditis elegans)
    Secernentea mrp-51 Protein MRP-5 48.44(n)
    39.06(a)
      181587  NM_078078.1  NP_510479.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes YOR16
    Plasma membrane ATP-binding cassette (ABC) transpo...
    29(a)
    1 → many
    VII(1052824-1057257)
    rice
    (Oryza sativa)
    Liliopsida Os02g02884001 hypothetical protein 45.68(n)
    36.76(a)
      4329047  NM_001053118.1  NP_001046583.1 


    ENSEMBL Gene Tree for ABCC5 (if available)
    TreeFam Gene Tree for ABCC5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ABCC5 gene
    ABCC42  ABCC122  ABCC102  ABCC12  CFTR2  ABCC82  ABCC32  ABCC22  
    ABCC112  ABCC92  
    18/21 SIMAP similar genes for ABCC5 using alignment to 8 protein entries:     MRP5_HUMAN (see all proteins) (see all similar genes):
    ABCB4    DKFZp434I2115    ABC-transporter    TAP1    ABCC12    MOAT-B
    ABCC11    NG-TRA    CFTR    ABCC4    ara    DKFZp781G125
    ABCC9    ABCC1    ABCC10    ABCC8    ABCC2    ABCC3

    ABCC5 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2159 SNPs in ABCC5 are shown (see all 2159)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs726250061,2
    C--183637236(+) ACCTCC/TGAGTT 1 -- ds50014Minor allele frequency- T:0.14CSA WA EA 241
    rs23132161,2
    C,F,A,H--183637251(-) CAGGAA/GAATCA 1 -- ds50018Minor allele frequency- G:0.44NA WA 136
    rs23132151,2
    C,F,A,H--183637301(-) CCTGGT/CGTGGT 1 -- ds50017Minor allele frequency- C:0.44NA WA 16
    rs1468658771,2
    --183637383(+) AGGGTA/CATTAT 1 -- ds50010--------
    rs1393005091,2
    --183637423(+) AACTAC/TTCATT 1 -- ds50010--------
    rs38051141,2
    C,F,H--183637722(-) GTAAAA/CCTCTT 1 -- ut3124Minor allele frequency- C:0.16EA NA NS WA 4176
    rs5621,2
    C,F,A,H--183637845(+) TTCAAC/TTGATG 1 -- ut3130Minor allele frequency- T:0.48MN EA NA NS WA CSA 4120
    rs1919572721,2
    --183637883(+) ACCAGC/GCCCAC 1 -- ut310--------
    rs1433300111,2
    C--183637898(+) CAAAGC/GGGGTT 1 -- ut310--------
    rs1845596481,2
    --183637998(+) ATTAGC/TAAGAG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for ABCC5 (183637722 - 183735803 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for ABCC5:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2726294CNV Deletion23290073
    esv2678542CNV Deletion23128226
    esv2726293CNV Deletion23290073
    nsv520094CNV Loss19592680
    dgv5353n71CNV Loss21882294
    esv1002813CNV Loss20482838
    esv25219CNV Loss19812545
    nsv878050CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605251    OMIM disorders: --

    20/37 diseases for ABCC5 (see all 37):    About MalaCards
    lymphoblastic leukemia    dysembryoplastic neuroepithelial tumor    dubin-johnson syndrome    acute lymphoblastic leukemia
    arteriovenous malformation    benign mesothelioma    acute liver failure    status epilepticus
    morquio syndrome b    leukemia    malignant mesothelioma    colon adenocarcinoma
    lung cancer    acute myeloid leukemia    malignant glioma    herpes simplex
    cytochrome p450    nasopharyngitis    cystic fibrosis    myeloid leukemia


    ABCC5 for disorders           About GeneDecksing

    10/12 Novoseek inferred disease relationships for ABCC5 gene (see all 12)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    breast cancer 40.9 12 10739113 (1), 15581025 (1), 17518506 (1), 12153153 (1) (see all 9)
    cancer 26.6 4 9270026 (1), 16337112 (1)
    lymphoblastic leukemia acute 26.2 3 10840050 (1), 12816874 (1)
    glioma 24.1 5 16193381 (4)
    arteriovenous malformations 15.9 1 16193381 (1)
    epilepsy 12.6 2 12699350 (1), 16193381 (1)
    small cell lung cancer 9.13 1 10100721 (1)
    leukemia 7.28 1 19142964 (1)
    immunodeficiency 2.35 1 15105153 (1)
    cancer lung 2.27 20 10728601 (6), 11745426 (3), 11766988 (1)

    Genetic Association Database (GAD): ABCC5
    Human Genome Epidemiology (HuGE) Navigator: ABCC5 (8 documents)

    Export disorders for ABCC5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ABCC5 gene, integrated from 9 sources (see all 142):
    (articles sorted by number of sources associating them with ABCC5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of MOAT-C and MOAT-D, new members of the MRP/cMOAT subfamily of transporter proteins. (PubMed id 9827529)1, 2, 3, 9 Belinsky M.G.... Kruh G.D. (1998)
    2. Multidrug-resistance protein 5 is a multispecific organic anion transporter able to transport nucleotide analogs. (PubMed id 10840050)1, 2, 7, 9 Wijnholds J.... Borst P. (2000)
    3. Characterization of the transport of nucleoside analog drugs by the human multidrug resistance proteins MRP4 and MRP5. (PubMed id 12695538)1, 7, 9 Reid G....Borst P. (2003)
    4. Detailed structural analysis on both human MRP5 and mouse mrp5 transcripts. (PubMed id 10721709)1, 2, 9 Suzuki T.... Nishio K. (2000)
    5. ATP-binding cassette C transporters in human pancreatic carcinoma cell lines. Upregulation in 5-fluorouracil-resistant cells. (PubMed id 19077464)1, 7, 9 Hagmann W....LAPhr J.M. (2009)
    6. Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines. (PubMed id 9270026)1, 2, 9 Kool M.... Borst P. (1997)
    7. The multidrug resistance protein 5 functions as an ATP-dependent export pump for cyclic nucleotides. (PubMed id 10893247)1, 7, 9 Jedlitschky G....Keppler D. (2000)
    8. Human skeletal muscle drug transporters determine loc al exposure and toxicity of statins. (PubMed id 19940267)1, 7, 9 Knauer M.J....Tirona R.G. (2010)
    9. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    10. Association of multi-drug resistance gene polymorphis ms with pancreatic cancer outcome. (PubMed id 20922799)1, 4 Tanaka M....Li D. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10057 HGNC: 56 AceView: ABCC5 Ensembl:ENSG00000114770 euGenes: HUgn10057
    ECgene: ABCC5 Kegg: 10057 H-InvDB: ABCC5

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ABCC5 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ABCC5 Genetics and Cytogenetics in Oncology and Haematology
    ABCMdbhttp://abcmutations.hegelab.org/proteinDetails?uniprot_id=O15440

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ABCC5 gene:
    Search GeneIP for patents involving ABCC5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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