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Aliases for ABCC5 Gene

Aliases for ABCC5 Gene

  • ATP Binding Cassette Subfamily C Member 5 2 3 5
  • ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 5 2 3
  • Multi-Specific Organic Anion Transporter C 3 4
  • MOAT-C 3 4
  • PABC11 3 4
  • MRP5 3 4
  • SMRP 3 4
  • Canalicular Multispecific Organic Anion Transporter C 3
  • ATP-Binding Cassette Sub-Family C Member 5 4
  • Multidrug Resistance-Associated Protein 5 3
  • EST277145 3
  • ABC33 3
  • MOATC 3

External Ids for ABCC5 Gene

Previous GeneCards Identifiers for ABCC5 Gene

  • GC03M180375
  • GC03M184632
  • GC03M185039
  • GC03M184958
  • GC03M185120
  • GC03M183637
  • GC03M181047

Summaries for ABCC5 Gene

Entrez Gene Summary for ABCC5 Gene

  • The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that this protein provides resistance to thiopurine anticancer drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. This protein may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside analogs in HIV-infected patients. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

GeneCards Summary for ABCC5 Gene

ABCC5 (ATP Binding Cassette Subfamily C Member 5) is a Protein Coding gene. Diseases associated with ABCC5 include Lymphoblastic Leukemia. Among its related pathways are Metabolism and Blood-Brain Barrier Pathway: Anatomy. GO annotations related to this gene include ATPase activity and organic anion transmembrane transporter activity. An important paralog of this gene is ABCC12.

UniProtKB/Swiss-Prot for ABCC5 Gene

  • Acts as a multispecific organic anion pump which can transport nucleotide analogs.

Gene Wiki entry for ABCC5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ABCC5 Gene

Genomics for ABCC5 Gene

Regulatory Elements for ABCC5 Gene

Enhancers for ABCC5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F183975 1 ENCODE 21.6 +40.9 40888 2.7 HDGF ATF1 PKNOX1 ARNT CREB3L1 ZNF121 NCOA1 CREB3 MEF2D MAFF ABCC5 HTR3C PARL RPSAP31 HTR3E-AS1 EIF2B5 EIF4G1 VWA5B2 FAM131A CAMK2N2
GH03F183913 0.8 ENCODE 22.7 +103.7 103749 2.8 SOX13 PKNOX1 SAP130 RARA ZNF121 CBX5 HNF4G NR2F6 CREM THAP11 ABCC5 PARL RPSAP31 EIF2B5 VWA5B2 HTR3C CAMK2N2 MAP6D1 CYP2AB1P PIR62380
GH03F183979 1 ENCODE 16.8 +36.6 36634 3.3 ATF1 CREB3L1 SIN3A DMAP1 ZNF48 GLIS2 ZNF766 ZNF207 SP3 SP5 ABCC5 ABCC5-AS1 PIR62380
GH03F184022 0.9 FANTOM5 Ensembl ENCODE 18.5 -4.5 -4486 1.0 JUN ABCC5 HTR3C PARL RPSAP31 EIF2B5 CAMK2N2 ALG3 ECE2 PSMD2 KLHL6
GH03F184015 1.1 ENCODE 14.3 +1.0 1013 3.6 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 ZNF2 YY1 HTR3D ENSG00000271682 ABCC5 LINC02069 HTR3C PARL EIF2B5 AP2M1 ALG3 CAMK2N2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ABCC5 on UCSC Golden Path with GeneCards custom track

Promoters for ABCC5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001381233 115 1800 HDGF PKNOX1 ARNT CREB3L1 MLX WRNIP1 ARID4B SIN3A FEZF1 ZNF2
ENSR00001855658 1315 201 TGIF2 ZFP37 PRDM1 CHAMP1
ENSR00001855657 1715 201 ZBTB2 TAL1 CHAMP1 ARID1B TGIF2 NCOR1 IKZF1 HMBOX1 SMAD4 NR2C2

Genomic Location for ABCC5 Gene

Chromosome:
3
Start:
183,919,934 bp from pter
End:
184,018,015 bp from pter
Size:
98,082 bases
Orientation:
Minus strand

Genomic View for ABCC5 Gene

Genes around ABCC5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ABCC5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ABCC5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ABCC5 Gene

Proteins for ABCC5 Gene

  • Protein details for ABCC5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15440-MRP5_HUMAN
    Recommended name:
    Multidrug resistance-associated protein 5
    Protein Accession:
    O15440
    Secondary Accessions:
    • B9EIQ2
    • O14517
    • Q29ZA9
    • Q29ZB1
    • Q86UX3
    • Q86W30
    • Q9UN85
    • Q9UNP5
    • Q9UQC3

    Protein attributes for ABCC5 Gene

    Size:
    1437 amino acids
    Molecular mass:
    160660 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ABCC5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ABCC5 Gene

Post-translational modifications for ABCC5 Gene

  • Ubiquitination at Lys 383
  • Glycosylation at Asn 494, Asn 636, Asn 684, Asn 890, Asn 897, Asn 1044, Asn 1329, and Asn 1417
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ABCC5 Gene

Domains & Families for ABCC5 Gene

Gene Families for ABCC5 Gene

Suggested Antigen Peptide Sequences for ABCC5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O15440

UniProtKB/Swiss-Prot:

MRP5_HUMAN :
  • Contains 2 ABC transmembrane type-1 domains.
  • Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
Domain:
  • Contains 2 ABC transmembrane type-1 domains.
  • Contains 2 ABC transporter domains.
Family:
  • Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
genes like me logo Genes that share domains with ABCC5: view

Function for ABCC5 Gene

Molecular function for ABCC5 Gene

GENATLAS Biochemistry:
ATP binding cassettte superfamily,subfamily C (CFTR/MRP),member 5
UniProtKB/Swiss-Prot Function:
Acts as a multispecific organic anion pump which can transport nucleotide analogs.

Gene Ontology (GO) - Molecular Function for ABCC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
GO:0008514 organic anion transmembrane transporter activity IEA,TAS --
GO:0016887 ATPase activity IEA --
GO:0042626 ATPase activity, coupled to transmembrane movement of substances IEA --
GO:0043225 ATPase-coupled anion transmembrane transporter activity TAS --
genes like me logo Genes that share ontologies with ABCC5: view
genes like me logo Genes that share phenotypes with ABCC5: view

Animal Models for ABCC5 Gene

MGI Knock Outs for ABCC5:

Animal Model Products

  • Taconic Biosciences Mouse Models for ABCC5

miRNA for ABCC5 Gene

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ABCC5 Gene

Localization for ABCC5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ABCC5 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ABCC5 gene
Compartment Confidence
plasma membrane 5
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ABCC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 9827529
GO:0016020 membrane IEA,IDA 15297306
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ABCC5: view

Pathways & Interactions for ABCC5 Gene

genes like me logo Genes that share pathways with ABCC5: view

Gene Ontology (GO) - Biological Process for ABCC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA,TAS 9827529
GO:0015711 organic anion transport IEA --
GO:0030213 hyaluronan biosynthetic process TAS --
GO:0055085 transmembrane transport IEA,TAS --
GO:0098656 anion transmembrane transport IEA --
genes like me logo Genes that share ontologies with ABCC5: view

No data available for SIGNOR curated interactions for ABCC5 Gene

Drugs & Compounds for ABCC5 Gene

(27) Drugs for ABCC5 Gene - From: DrugBank, PharmGKB, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cisplatin Approved Pharma Transporter, inducer Inhibits DNA synthesis,chemotherapy drug, Platinum, Potent pro-apoptotic anticancer agent; activates caspase-3 2690
Probenecid Approved Pharma Inhibition, Inhibitor, Transporter, inhibitor 27
Fluorouracil Approved Pharma Transporter, substrate RNA processing inhibitor and thymidylate synthase inhibitor 1791
Adefovir Dipivoxil Approved, Investigational Pharma Transporter, substrate 133
Dipyridamole Approved Pharma Inhibition, Inhibitor, Transporter, inhibitor Adenosine transport inhibitor 80

(8) Additional Compounds for ABCC5 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ABCC5: view

Transcripts for ABCC5 Gene

Unigene Clusters for ABCC5 Gene

ATP-binding cassette, sub-family C (CFTR/MRP), member 5:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ABCC5 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15a · 15b · 15c ^ 16a · 16b ^ 17 ^ 18 ^
SP1: - - - - - -
SP2: - - - - - -
SP3: -
SP4: - -
SP5: -
SP6: -
SP7:

ExUns: 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34a · 34b
SP1:
SP2: -
SP3:
SP4:
SP5:
SP6:
SP7:

Relevant External Links for ABCC5 Gene

GeneLoc Exon Structure for
ABCC5
ECgene alternative splicing isoforms for
ABCC5

Expression for ABCC5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ABCC5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ABCC5 Gene

This gene is overexpressed in Muscle - Skeletal (x4.8).

Protein differential expression in normal tissues from HIPED for ABCC5 Gene

This gene is overexpressed in Lung (59.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ABCC5 Gene



Protein tissue co-expression partners for ABCC5 Gene

NURSA nuclear receptor signaling pathways regulating expression of ABCC5 Gene:

ABCC5

SOURCE GeneReport for Unigene cluster for ABCC5 Gene:

Hs.743953

mRNA Expression by UniProt/SwissProt for ABCC5 Gene:

O15440-MRP5_HUMAN
Tissue specificity: All isoforms are equally expressed in retina.
genes like me logo Genes that share expression patterns with ABCC5: view

Primer Products

Orthologs for ABCC5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ABCC5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ABCC5 35
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ABCC5 34 35
  • 92.6 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ABCC5 35
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ABCC5 35
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Abcc5 34 16 35
  • 88.83 (n)
rat
(Rattus norvegicus)
Mammalia Abcc5 34
  • 88.23 (n)
chicken
(Gallus gallus)
Aves ABCC5 34
  • 79.75 (n)
lizard
(Anolis carolinensis)
Reptilia ABCC5 35
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101732220 34
  • 73.67 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC68608 34
zebrafish
(Danio rerio)
Actinopterygii abcc5 34 35
  • 68.8 (n)
fruit fly
(Drosophila melanogaster)
Insecta Sur 36 35
  • 42 (a)
CG7806 36
  • 29 (a)
worm
(Caenorhabditis elegans)
Secernentea mrp-5 34
  • 48.41 (n)
rice
(Oryza sativa)
Liliopsida Os02g0288400 34
  • 45.77 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 45 (a)
OneToMany
Species where no ortholog for ABCC5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ABCC5 Gene

ENSEMBL:
Gene Tree for ABCC5 (if available)
TreeFam:
Gene Tree for ABCC5 (if available)

Paralogs for ABCC5 Gene

Paralogs for ABCC5 Gene

genes like me logo Genes that share paralogs with ABCC5: view

Variants for ABCC5 Gene

Sequence variations from dbSNP and Humsavar for ABCC5 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs386352272 Uncertain significance 183,965,410(-) AGACA(A/G)CATCC reference, missense
rs1016752 -- 183,947,274(-) TTCCT(C/G)TGCTG intron-variant
rs10460893 -- 183,978,321(+) TTTTT(G/T)TTTGT intron-variant
rs1053351 -- 183,942,815(-) AGGTA(A/C)CGAGA reference, stop-gained
rs1053386 -- 183,978,599(-) CAGAG(C/T)ATCAC reference, synonymous-codon, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for ABCC5 Gene

Variant ID Type Subtype PubMed ID
nsv955573 CNV deletion 24416366
nsv592656 CNV gain 21841781
nsv520094 CNV loss 19592680
nsv1077428 CNV duplication 25765185
nsv1073270 CNV deletion 25765185
esv3893835 CNV loss 25118596
esv3598936 CNV gain 21293372
esv3598935 CNV gain 21293372
esv3598934 CNV gain 21293372
esv3563008 CNV deletion 23714750
esv2726294 CNV deletion 23290073
esv2726293 CNV deletion 23290073
esv2678542 CNV deletion 23128226
esv25219 CNV loss 19812545
esv1002813 CNV loss 20482838

Variation tolerance for ABCC5 Gene

Residual Variation Intolerance Score: 0.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.90; 35.42% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ABCC5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ABCC5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ABCC5 Gene

Disorders for ABCC5 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ABCC5 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
lymphoblastic leukemia
  • leukemia, lymphoid
- elite association - COSMIC cancer census association via MalaCards
Search ABCC5 in MalaCards View complete list of genes associated with diseases

Relevant External Links for ABCC5

Genetic Association Database (GAD)
ABCC5
Human Genome Epidemiology (HuGE) Navigator
ABCC5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ABCC5
genes like me logo Genes that share disorders with ABCC5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ABCC5 Gene

Publications for ABCC5 Gene

  1. Multidrug-resistance protein 5 is a multispecific organic anion transporter able to transport nucleotide analogs. (PMID: 10840050) Wijnholds J. … Borst P. (Proc. Natl. Acad. Sci. U.S.A. 2000) 3 4 22 25 64
  2. Characterization of MOAT-C and MOAT-D, new members of the MRP/cMOAT subfamily of transporter proteins. (PMID: 9827529) Belinsky M.G. … Kruh G.D. (J. Natl. Cancer Inst. 1998) 2 3 4 22 64
  3. Characterization of the transport of nucleoside analog drugs by the human multidrug resistance proteins MRP4 and MRP5. (PMID: 12695538) Reid G. … Borst P. (Mol. Pharmacol. 2003) 3 22 25 64
  4. Detailed structural analysis on both human MRP5 and mouse mrp5 transcripts. (PMID: 10721709) Suzuki T. … Nishio K. (Gene 2000) 3 4 22 64
  5. The multidrug resistance protein 5 functions as an ATP-dependent export pump for cyclic nucleotides. (PMID: 10893247) Jedlitschky G. … Keppler D. (J. Biol. Chem. 2000) 3 22 25 64

Products for ABCC5 Gene

Sources for ABCC5 Gene

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