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ABCC5 Gene

protein-coding GIFtS: 63

GC03M185120

ATP-binding cassette, sub-family C (CFTR/MRP), member 5
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
ABC33 ^²
DKFZp686C1782 ^²
EST277145 ^¹, ²
MOAT-C ^¹, ², ³
MOATC ^², ⁵
MRP5 ^¹, ², ³, ⁵
SMRP ^¹, ², ³
pABC11 ^², ³

Descriptions
ATP-binding cassette sub-family C member 5 ^³
ATP-binding cassette, sub-family C (CFTR/MRP), member 5 ^²
ATP-binding cassette, sub-family C, member 5 ^²
Multi-specific organic anion transporter C ^³
canalicular multispecific organic anion transporter C ^²

External Ids
HGNC: 56¹
Entrez Gene: 10057²
UniProtKB: O15440³
Ensembl: ENSG00000114770⁷

Search outside databases for aliases for ABCC5 gene

Previous GC identifers: GC03M180375 GC03M184632 GC03M185039 GC03M184958

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for ABCC5:

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC)

transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes.

ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20,

White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance.

This protein functions in the cellular export of its substrate, cyclic nucleotides. This export

contributes to the degradation of phosphodiesterases and possibly an elimination pathway for

cyclic nucleotides. Studies show that this protein provides resistance to thiopurine anticancer

drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine.

This protein may be involved in resistance to thiopurines in acute lymphoblastic leukemia and

antiretroviral nucleoside analogs in HIV-infected patients. Alternative splicing of this gene has

been detected; however, the complete sequence and translation initiation site is unclear.

[provided by RefSeq]

UniProtKB/Swiss-Prot: MRP5_HUMAN, O15440

Function: Acts as a multispecific organic anion pump which can transport nucleotide analogs

Gene Wiki entry for ABCC5

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ABCC5 gene

Entrez Gene cytogenetic band: 3q27 Ensembl cytogenetic band: 3q27.1 HGNC cytogenetic band: 3q27

ABCC5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03M185120: (about GC identifiers)

Start:	185,120,416 bp from pter
End:	185,218,421 bp from pter
Size:	98,006 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000003.10 NT_005612.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: MRP5_HUMAN, O15440 (See protein sequence)

Recommended Name: Multidrug resistance-associated protein 5

Size: 1437 amino acids; 160660 Da

Subcellular location: Membrane; Multi-pass membrane protein

Secondary accessions: O14517 Q9UN85 Q9UNP5 Q9UQC3

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_001018881.1 NP_005679.2

ENSEMBL proteins:

ENSP00000333926 ENSP00000265586 ENSP00000371935 ENSP00000376358 ENSP00000371934 ENSP00000376357

ENSP00000376356

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (MRP5)
	Human Recombinant Proteins from Abnova (ABCC5)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005624	membrane fraction	IDA	15297306
GO:0005887	integral to plasma membrane	TAS	9827529
GO:0016020	membrane	IEA	--

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Antibodies for ABCC5:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for ABCC5
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (MRP5), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (ABCC5)
	Novus Biologicals Antibodies for ABCC5

Assays for ABCC5:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry O15440

ProtoNet protein and cluster: O15440

UniProtKB/Swiss-Prot: MRP5_HUMAN, O15440

Similarity: Belongs to the ABC transporter family. Conjugate transporter (TC 3.A.1.208) subfamily

Similarity: Contains 2 ABC transmembrane type-1 domains

Similarity: Contains 2 ABC transporter domains

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ABCC5)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ABCC5)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001023587

Applied Biosystems Silencer® siRNAs for ABCC5

Sigma-Aldrich siRNA and siRNA Panels for ABCC5

Sigma-Aldrich shRNA for ABCC5

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001023587
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001023587
untagged cDNA clones in CMV expression vector (see all 3): AK090667

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_005688

UniProtKB/Swiss-Prot: MRP5_HUMAN, O15440

Function: Acts as a multispecific organic anion pump which can transport nucleotide analogs

Genatlas biochemistry entry for ABCC5:

ATP binding cassettte superfamily,subfamily C (CFTR/MRP),member 5

1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Abcc5):

cellular

5 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0005524	ATP binding	TAS	9325169
GO:0008514	organic anion transmembrane transporter activity	TAS	9827529
GO:0016887	ATPase activity	IEA	--
GO:0042626	ATPase activity, coupled to transmembrane movement of substances	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5/9 Interacting proteins for ABCC5 (ENSP00000333926³) via UniProtKB, MINT, and/or STRING (see all 9 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
MRPS7	ENSP00000245539³	STRING (score=.887)
GCLC	ENSP00000229416³	STRING (score=.792)
ABCG2	ENSP00000237612³	STRING (score=.777)
SLC36A1	ENSP00000243389³	STRING (score=.752)
CD9	ENSP00000009180³	STRING (score=.75)

About this table

1 Gene Ontology (GO) biological process term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006810	transport	TAS	9827529

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for ABCC5
5 Novoseek chemical compound relationships for ABCC5 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
s-(2,4-dinitrophenyl)glutathione	80.76	2	10840050 (1)
nucleoside	58.05	11	12695538 (2), 10840050 (1), 15897250 (1), 15816546 (1) (see all 5)
cgmp	55.80	24	11956491 (3), 14507663 (2), 16614078 (2), 17540771 (2) (see all 8)
atp	35.62	6	17803828 (2), 11956491 (1), 16265591 (1)
platinum	14.57	11	10728601 (5), 16337112 (1)

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5 PharmGKB drug compound relationships for ABCC5 gene

Drug compound	PharmGKB Relations	PubMed IDs for articles supporting these relationships
6-mercaptopurine	FA	12435799 10840050
6-thioguanine	FA	12435799 10840050
nucleosides	FA	10840050
sildenafil	FA	10893247
xenobiotics	FA	10840050

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ABCC5)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ABCC5)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001023587

Sigma-Aldrich siRNA and siRNA Panels for ABCC5

Sigma-Aldrich shRNA for ABCC5

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001023587 NM_005688

REFSEQ mRNAs for ABCC5 gene (2 alternative transcripts):

NM_001023587.1 NM_005688.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001023587 NM_005688

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001023587
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001023587
                                 untagged cDNA clones in CMV expression vector (see all 3): AK090667

Additional cDNA sequence:

AB005659.1 AB019002.1 AB209103.1 AB209454.1 AF104942.1 AF146074.1 AK090667.1 AL359600.1

AY196484.1 AY754874.1 AY754875.1 AY754876.1 BC015334.1 BC050744.1 BC051358.1 BC140771.1

BC142670.1 BC142719.1 BC144495.1 BX647245.1 BX649032.1 CR590924.1 CR619835.1 U66687.1

U83661.2

15 DOTS entries:

DT.91688348 DT.312745 DT.100804398 DT.97801613 DT.455723 DT.86857789 DT.120866548 DT.120866554

DT.91755905 DT.97847973 DT.100746639 DT.120866613 DT.406116 DT.97813740 DT.97813791

24/289 AceView cDNA sequences (see all 289 ):

AA653545 AL543173 AI911655 BU676278 AA866214 T87404 AW964148 AW135435

BM705344 BU855794 AI493704 CR590924 BM747688 AW341670 BE336596 BU184871

BM310090 AA378333 BM987281 BQ272598 CA489265 BM310353 BQ225211 BC051358

highest scoring ESTs for ABCC5:

AF104942 U83661 AF146074 AA004966 AA188256 AA317271 AA337472 AA338144 AA378333 AA481269

Unigene Cluster for ABCC5:

ATP-binding cassette, sub-family C (CFTR/MRP), member 5

Hs.719074 [show with all ESTs]

Unigene Representative Sequence: AF146074

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for ABCC5 (see all 7 )

ExUns:	1a	·	1b	·	1c	·	1d	^	2a	·	2b	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11a	·	11b	^	12	^	13	^	14	^	15a	·	15b	·	15c	^	16a	·	16b	^	17	^	18	^
SP1:													-		-								-		-														-								-
SP2:													-		-								-		-														-								-
SP3:																																															-
SP4:													-		-
SP5:															-

ExUns:	19	^	20	^	21	^	22	^	23	^	24	^	25	^	26	^	27	^	28	^	29	^	30	^	31	^	32	^	33	^	34a	·	34b
SP1:
SP2:															-
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for ABCC5

7 Ensembl transcripts including schematic representations:

ENST00000334444 ENST00000265586 ENST00000382495 ENST00000392579 ENST00000382494 ENST00000392578

ENST00000392577

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

ABCC5 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ABCC5

¹ / ² / ³

10 probe-sets matching ABCC5 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
45114_at²^{, 3}	U95-B	1	1.00	1.00	0.84	1.36	AI815763	0.60	1.00	0.82	1
41428_at²^{, 3}	U95-A	1	1.00	1.00	0.88	1.01	AF104942	1.00	1.00	1.00	1
1932_at²^{, 3}	U95-A	1	1.00	1.00	0.91	1.09	U83661	1.00	1.00	1.00	1
43267_at²^{, 3}	U95-B	1	1.00	1.00	0.48	0.42	AA481269	0.60	1.00	0.82	1
1933_g_at²^{, 3}	U95-A	1	1.00	1.00	0.87	1.16	U83661	1.00	1.00	1.00	1
209380_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AF146074	0.80	1.00	0.91	1
226363_at²^{, 3}	U133-B	1	1.00	1.00	--	--	BE550362	0.40	1.00	0.76	1
209380_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
226363_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1558460_at²	U133Plus2	1	0.55	1.00	--	--	--	--	--	--	--

GeneDecks ABCC5 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.719074
Expression variation in blood from EXPOLDB for ABCC5

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ABCC5 gene from 5/11 species (see all 11 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ABCC5¹	--	ATP-binding cassette, sub-family C (CFTR/MRP), member more	92.46(n) 96.1(a)	478648 XM_852261.1 XP_857354.1
cow (Bos taurus)	ABCC5¹	--	ATP-binding cassette, sub-family C (CFTR/MRP), member more	91.58(n) 95.27(a)	511769 XM_001251890.1 XP_001251891.1
rat (Rattus norvegicus)	Abcc5¹	--	ATP-binding cassette, sub-family C (CFTR/MRP), member more	88.23(n) 94.85(a)	116721 NM_053924.1 NP_446376.1
mouse (Mus musculus)	Abcc5^{1, 5}	16 (14.00 cM)⁵	ATP-binding cassette, sub-family C (CFTR/MRP), member more^{1, 5}	88.83(n)¹ 95.06(a)¹	27416¹ NM_013790.2¹ NP_038818.2¹ AA119896⁵ AB012090⁵ (see all 18)
chicken (Gallus gallus)	ABCC5¹	--	ATP-binding cassette, sub-family C (CFTR/MRP), member more	79.73(n) 89.12(a)	424947 XM_422754.2 XP_422754.2

About this table Species with no ortholog for ABCC5

ENSEMBL Gene Tree for ABCC5

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for ABCC5 gene

ABCC4²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/634 NCBI SNPs in ABCC5 are shown (see all 634 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 210)

AB	SNP ID	Valid	Chr 3 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs939337^1,2	A,C,F,H,O	185183841(+)	`CATTTC/GTTTAC`	2	--	int¹ ng5¹		12		EA NA EU WA	908
	rs4148575^1,2	A,C,F,H	185184969(-)	`GGGTTC/TTGGAA`	2	--	ut3¹ int¹		4		EU EA WA	420
	rs562^1,2	A,C,F,H	185120539(+)	`TTCAAT/CTGATG`	1	--	ut3¹		10		MN EA NA EU WA	2406
	rs3805114^1,2	C,F,H	185120416(-)	`GTAAAA/CCTCTT`	1	--	ut3¹		12		EA NA EU WA	2482
--	rs3749440^1,2	C,F	185184783(-)	`TGTGGC/TTTTTT`	2	--	int¹ ut3¹		1		EA	1490
	rs28365015^1,2	C,F	185150259(-)	`CTACAA/GTAAAG`	1	N/S	mis¹ ese³		2		--	1104
--	rs1520195^1,2	A,C	185219576(-)	`GCTAGC/TTGTTA`	2	--	ng3¹		0	--	--	--	--
--	rs7627754^1,2	A,C	185220050(+)	`AATAaA/Ttattc`	2	--	ng3¹		0	--	--	--	--
--	rs3749444^1,2	C,F	185121723(-)	`GGGGCG/AGGCCC`	1	--	ut3¹ ese³		2		--	1104
--	rs2313216^1,2	A,C	185119945(-)	`caggaA/Gaatca`	1	--	ng5¹		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for ABCC5 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 605251

10/12 Novoseek disease relationships for ABCC5 gene (see all 12 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
breast cancer	38.38	12	10739113 (1), 15581025 (1), 17518506 (1), 12153153 (1) (see all 9)
lymphoblastic leukemia acute	27.84	3	10840050 (1), 12816874 (1)
cancer	26.15	4	9270026 (1), 16337112 (1)
glioma	19.19	5	16193381 (4)
arteriovenous malformations	17.66	1	16193381 (1)
small cell lung cancer	10.75	1	10100721 (1)
leukemia	8.98	1	19142964 (1)
epilepsy	7.12	2	12699350 (1), 16193381 (1)
cancer lung	4.58	20	10728601 (6), 11745426 (3), 11766988 (1)
immunodeficiency	3.91	1	15105153 (1)

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2 PharmGKB disease relationships for ABCC5 gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Heart Failure, Congestive	FA	14507663
Leukemia, Lymphocytic, Acute, L1	FA	10840050

About this table

Human Genome Epidemiology Navigator: ABCC5 (2 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/110 PubMed articles for ABCC5 gene (see all 110 ):

Multidrug-resistance protein 5 is a multispecific organic anion transporter able to transport nucleotide analogs. (PubMed id 10840050)^{1, 3, 4, 7} Wijnholds J.... Borst P. (2000)
Characterization of MOAT-C and MOAT-D, new members of the MRP/cMOAT subfamily of transporter proteins. (PubMed id 9827529)^{1, 2, 3, 4} Belinsky M.G....Kruh G.D. (1998)
Expression and localization of the multidrug resistance protein 5 (MRP5/ABCC5), a cellular export pump for cyclic nucleotides, in human heart. (PubMed id 14507663)^{1, 3, 7} Dazert P....Kroemer H.K. (2003)
The multidrug resistance protein 5 functions as an ATP-dependent export pump for cyclic nucleotides. (PubMed id 10893247)^{1, 3, 7} Jedlitschky G....Keppler D. (2000)
Detailed structural analysis on both human MRP5 and mouse mrp5 transcripts. (PubMed id 10721709)^{1, 3, 4} Suzuki T.... Nishio K. (2000)
Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines. (PubMed id 9270026)^{1, 3, 4} Kool M.... Borst P. (1997)
Thiopurine metabolism and identification of the thiopurine metabolites transported by MRP4 and MRP5 overexpressed in human embryonic kidney cells. (PubMed id 12435799)^{1, 7} Wielinga P.R....Borst P. (2002)
pABC11 (also known as MOAT-C and MRP5), a member of the ABC family of proteins, has anion transporter activity but does not confer multidrug resistance when overexpressed in human embryonic kidney 293 cells. (PubMed id 10438534)^{3, 4} McAleer M.A.... Matthews N. (1999)
cDNA cloning of a short type of multidrug resistance protein homologue, SMRP, from a human lung cancer cell line. (PubMed id 9325169)^{3, 4} Suzuki T.... Saijo N. (1997)
Characterization of the human ABC superfamily: isolation and mapping of 21 new genes using the expressed sequence tags database. (PubMed id 8894702)^{2, 3} Allikmets R....Dean M. (1996)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 10057	HGNC: 56	AceView: ABCC5	Ensembl:ENSG00000114770	euGenes: HUgn10057
ECgene: ABCC5	H-InvDB: ABCC5

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for ABCC5	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for ABCC5
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for ABCC5:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ABCC5-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ABCC5		Antibodies for ABCC5
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for ABCC5		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (ABCC5)
	Antibodies (ABCC5)
	Chimera RNAi (ABCC5)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (MRP5)
	Antibodies (MRP5)

Search OriGene for ABCC5

Search Tocris compounds for ABCC5

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for ABCC5

GeneCards Homepage - Last full update: 1 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
ABCC5 Gene at Home site.
Version 2.41.1
server5.xennexinc.com

ABCC5 Gene

protein-coding GIFtS: 63

Aliases &
Descriptions
for ABCC5

Summaries
for ABCC5

Genomic Location
for ABCC5

Proteins
for ABCC5

Protein Domains/
Families
for ABCC5

Gene Function
for ABCC5

Pathways & Interactions
for ABCC5

Drugs & Compounds
for ABCC5

Transcripts
for ABCC5

Expression
for ABCC5

Orthologs
for ABCC5

Paralogs
for ABCC5

SNPs/Variants
for ABCC5

Disorders & Mutations
for ABCC5

Medical News
for ABCC5

Publications
for ABCC5

Search for ABCC5

Genome Databases showing ABCC5

Other Databases showing ABCC5

Specialized Databases showing ABCC5

Licensable Technologies
for ABCC5

Services
for ABCC5

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ABCC5 Gene

protein-coding GIFtS: 63

Aliases & Descriptionsfor ABCC5

Summariesfor ABCC5

Genomic Locationfor ABCC5

Proteinsfor ABCC5

Protein Domains/Familiesfor ABCC5

Gene Functionfor ABCC5

Pathways & Interactionsfor ABCC5

Drugs & Compoundsfor ABCC5

Transcriptsfor ABCC5

Expression for ABCC5

Orthologsfor ABCC5

Paralogsfor ABCC5

SNPs/Variantsfor ABCC5

Disorders & Mutationsfor ABCC5

Medical Newsfor ABCC5

Publicationsfor ABCC5

Search for ABCC5

Genome Databases showing ABCC5

Other Databases showing ABCC5

Specialized Databases showing ABCC5

Licensable Technologiesfor ABCC5

Servicesfor ABCC5

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ABCC5

Summaries
for ABCC5

Genomic Location
for ABCC5

Proteins
for ABCC5

Protein Domains/
Families
for ABCC5

Gene Function
for ABCC5

Pathways & Interactions
for ABCC5

Drugs & Compounds
for ABCC5

Transcripts
for ABCC5

Expression
for ABCC5

Orthologs
for ABCC5

Paralogs
for ABCC5

SNPs/Variants
for ABCC5

Disorders & Mutations
for ABCC5

Medical News
for ABCC5

Publications
for ABCC5

Licensable Technologies
for ABCC5

Services
for ABCC5