ABCC4 Gene
protein-coding GIFtS : 66
GCID: GC13 M095672
ATP-binding cassette, sub-family C (CFTR/MRP), member 4
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Aliasesfor ABCC4 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 4 1 2 ATP-Binding Cassette Sub-Family C Member 42 3 MRP41 2 3 5 MRP/CMOAT-Related ABC Transporter2 3 MOAT-B1 2 3 BA464I2.1 (ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 4)2 MOATB1 2 5 Canalicular Multispecific Organic Anion Transporter (ABC Superfamily)2 EST1702051 2 Multidrug Resistance-Associated Protein 42 Multi-Specific Organic Anion Transporter B2 3 Multispecific Organic Anion Transporter B2
Export aliases for ABCC4 gene to outside databases Previous GC identifers: GC13M094033 GC13M090059 GC13M094508 GC13M093370 GC13M094470 GC13M076269
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Summariesfor ABCC4 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for ABCC4 : The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The specific function of this protein has not yet been determined; however, this protein may play a role in cellular detoxification as a pump for its substrate, organic anions. Alternative splicing results in multiple splice variants encoding different isoforms. (provided by RefSeq, Jul 2008) UniProtKB/Swiss-Prot: MRP4_HUMAN, O15439 Function : May be an organic anion pump relevant to cellular detoxificationGene Wiki entry for ABCC4
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Genomic Viewsfor ABCC4 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000013.10 NC_018924.1 NT_009952.14 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the ABCC4 gene promoter: GR Sp1 ATF-2 GR-beta CUTL1 E4BP4 C/EBPalpha c-Ets-1 N-Myc GR-alpha Other transcription factors Search SABiosciences Chromatin IP Primers for ABCC4 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat ABCC4
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 13q32 Ensembl cytogenetic band: 13q32.1 HGNC cytogenetic band: 13q31 ABCC4 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 13 GeneLoc Exon Structure
GeneLoc location for GC13M095672: view genomic region
(about GC identifiers )
Start:
95,672,083 bp from pter
End:
95,953,687 bp from pter
Size:
281,605 bases
Orientation:
minus strand
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Proteinsfor ABCC4 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: MRP4_HUMAN, O15439 (See
protein sequence )Recommended Name: Multidrug resistance-associated protein 4 Size : 1325 amino acids; 149527 Da
Subcellular location : Membrane; Multi-pass membrane protein
Secondary accessions : A9Z1Z7 Q8IVZ4 Q8IZN6 Q8NEW8 Q9Y6J2Alternative splicing : 3 isoforms : O15439-1 O15439-2 O15439-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for ABCC4: NX_O15439 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_O15439 ABCC4 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins (2 alternative transcripts):
NP_001098985.1 NP_005836.2 ENSEMBL proteins: ENSP00000366084 ENSP00000388657 ENSP00000442024 ENSP00000398562 ENSP00000440160 Reactome Protein details: O15439 Human Recombinant Protein Products: Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view) : About this table
ABCC4 for ontologies About GeneDecksing ABCC4 Antibody Products: Assay Products for ABCC4:
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Protein
Domains / Familiesfor ABCC4 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
ABCC4 for domains About GeneDecksing 5/6 InterPro domains/families (see all 6 ):
Graphical View of Domain Structure for InterPro Entry O15439 ProtoNet protein and cluster: O15439
UniProtKB/Swiss-Prot: MRP4_HUMAN, O15439 Similarity : Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamilySimilarity : Contains 2 ABC transmembrane type-1 domainsSimilarity : Contains 2 ABC transporter domains
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Functionfor ABCC4 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: MRP4_HUMAN, O15439 Function : May be an organic anion pump relevant to cellular detoxification
Genatlas biochemistry entry for ABCC4 : ATP binding cassette superfamily,subfamily C (CFTR/MRP),member 4 Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for ABCC4 (see all 6 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for ABCC4 (see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 2 ): ABCC4 (NM_005845 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ABCC4 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat ABCC4
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ABCC4
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005524 ATP binding
IEA -- GO:0016404 15-hydroxyprostaglandin dehydrogenase (NAD+) activity
NAS 7557451 GO:0042626 ATPase activity, coupled to transmembrane movement of substances
IEA --
ABCC4 for ontologies About GeneDecksing 1 GenomeRNAi human phenotype for ABCC4 :Animal Models: Mouse knock-outs for ABCC4: Abcc4 tm1Kruh Abcc4 tm1Jsch 12 MGI mutant phenotypes (inferred from 4 alleles ) (MGI details for Abcc4) :
ABCC4 for phenotypes About GeneDecksing
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Pathways & Interactionsfor ABCC4 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways  - 5/14 super-pathways (see all 14 ) About this table See pathways by source Super-pathway contained gene-specific pathways 1 Platelet activation, signaling and aggregation 2 Platelet degranulation 3 Acetaminophen Pathway, Pharmacokinetics 4 Fluoropyrimidine Activity 5 ABC-family proteins mediated transport
Pathway sources See GeneCards unified pathways Show all pathways 1
Cell Signaling Technology (CST) Pathway for ABCC4 2 BioSystems Pathways for ABCC4 5/6
Reactome Pathways for ABCC4 (see all 6 )5/9 PharmGKB Pathways for ABCC4 (see all 9 )2
Kegg Pathways (Kegg details for ABCC4) :
ABCC4 for pathways About GeneDecksing Interactions: SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ABCC4 STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)4 Interacting proteins for ABCC4 (O15439 3 ENSP00000366084 4 ) via UniProtKB, MINT, STRING , and/or I2D About this table Gene Ontology (GO): 5 biological process terms (GO ID links to tree view) : About this table
ABCC4 for ontologies About GeneDecksing
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Drugs & Compoundsfor ABCC4 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section
ABCC4 for compounds About GeneDecksing Browse Tocris compounds for ABCC4 10/34 DrugBank Compounds for ABCC4 (see all 34 ) About this table 10/48 Novoseek chemical compound relationships for ABCC4 gene (see all 48 ) About this table
Compound
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
mk 571
85.1
4
16132345 (1), 12695538 (1)
adefovir
83
47
17110501 (5), 19735648 (3), 10470083 (3), 18364470 (2) (see all 12 )
probenecid
75.9
3
15504935 (2), 18930752 (1)
sulfinpyrazone
74.3
1
15504935 (1)
nucleoside monophosphate
69.1
3
15026196 (1), 10470083 (1), 12695538 (1)
androstane
65.6
2
15004017 (1), 18662272 (1)
nucleoside
63.1
20
10470083 (2), 12695538 (2), 15827327 (1), 15364914 (1) (see all 11 )
tenofovir
61.7
12
17110501 (4), 17503669 (3), 20149322 (1)
tenofovir disoproxil fumarate
60
5
17083032 (3), 20149322 (1)
6 thioguanine
58.7
2
11447229 (1), 12435799 (1)
4 PharmGKB related drug/compound annotations for ABCC4 gene About this table Search CenterWatch for drugs/clinical trials and news about ABCC4 / MRP4
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Transcriptsfor ABCC4 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for ABCC4 gene (2 alternative transcripts): NM_001105515.1 NM_005845.3 Unigene Cluster for ABCC4:
ATP-binding cassette, sub-family C (CFTR/MRP), member 4 Hs.508423 [show with all ESTs ] Unigene Representative Sequence: NM_005845 9 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000376887 (uc001vmd.4 ) ENST00000484109 ENST00000471041 ENST00000474158 ENST00000467685 ENST00000412704 (uc010afj.3 uc010afk.3 ) ENST00000536256 (uc010tih.1 )ENST00000431522 (uc001vme.2 uc010afl.1 uc010afm.1 ) ENST00000538287 (uc001vmf.2 )Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for ABCC4 (see all 6 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for ABCC4 (see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 2 ): ABCC4 (NM_005845 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ABCC4 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat ABCC4
Additional cDNA sequence: AB208973.1 AF071202.1 AF071203.1 AF339763.1 AF541977.1 AK290317.1 AK296247.1 AK298953.1 AK309460.1 AY081219.1 AY133678.1 AY133679.1 AY133680.1 AY207008.1 BC041560.1 BX647118.1 U66686.1 U83660.1
20 DOTS entries : DT.115026 DT.92431917
DT.120783528 DT.99998873 DT.100764438 DT.91729507 DT.100764437 DT.120783477 DT.100764439 DT.40310418 DT.100651779 DT.101972277 DT.92431915 DT.97769103 DT.120783530 DT.120783536 DT.95374219 DT.100810521 DT.120783466 DT.40241131 24/125 AceView cDNA sequences (see all 125 ):
AL699662 BX474791 BM556442 BM462073 BP382967 BQ889997 W31962 N79659 AA305627 AY207008 BE879353 BE552099 BM553694 AA860581 Z45397 AA216367 AA035221 AF339763 N63981 CF597322 AI419629 BM979399 AI470523 AA229426 GeneLoc Exon Structure 5/9 Alternative Splicing Database (ASD) splice patterns (SP) for ABCC4 (see all 9 ) About this scheme ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25a · SP1 :   -   -                                           -     -   SP2 :   -   -                                 -           -     -   SP3 :   -   -                                                 SP4 :                                                     SP5 :     -                                                
ExUns: 25b ^ 26a · 26b ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35a · 35b SP1 :             -               SP2 :             -               SP3 :                           SP4 :                           SP5 :                          
ECgene alternative splicing isoforms for ABCC4
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Expression for ABCC4 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section ABCC4 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: GTTCGTATTT
About this image ABCC4 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table See ABCC4 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for ABCC4 SOURCE GeneReport for Unigene cluster: Hs.508423 UniProtKB/Swiss-Prot: MRP4_HUMAN, O15439 Tissue specificity : Widely expressed, with particularly high levels in prostate, but is barely detectable in liver SABiosciences Expression via Pathway-Focused PCR Array including ABCC4 : Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for ABCC4Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat ABCC4 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat ABCC4 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat ABCC4 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ABCC4
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Orthologsfor ABCC4 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of eukaryotes.
Orthologs for ABCC4 gene from 6/22 species (see all 22 ) About this table
Organism
Taxonomic classification
Gene
Description
Human Similarity
Orthology Type
Details
chicken (Gallus gallus)
Aves
ABCC41
ATP-binding cassette, sub-family C (CFTR/MRP), member more
74.9(n) 78.4(a)
 
418791 NM_001030819.1 NP_001025990.1
lizard (Anolis carolinensis)
Reptilia
ABCC46
--
72(a)
1 ↔ 1
3(85023613-85193849)
zebrafish (Danio rerio)
Actinopterygii
abcc41
ATP-binding cassette, sub-family C (CFTR/MRP), member more
65.83(n) 70.1(a)
 
368620 NM_001007038.1 NP_001007039.1
fruit fly (Drosophila melanogaster)
Insecta
CG92703 CG45621
ATP-binding cassette (ABC) transporter3 CG45621
46(a) (best of 10)3 51.43(n) 1 46.81(a) 1
 
38F63 42362 1 NM_142581.1 1 NP_650838.1 1
worm (Caenorhabditis elegans)
Secernentea
mrp-61 , 3
ABC transporter3 Protein MRP-61
35(a) (best of 2)3 48.99(n) 1 39.31(a) 1
 
X(4213362-4221731)3 180691 1 NM_076309.3 1 NP_508710.2 1
rice (Oryza sativa)
Liliopsida
Os.332122
Oryza sativa (japonica cultivar-group) cDNA cloneJ more
71.59(n)
 
NM_190319.1
ENSEMBL Gene Tree for ABCC4 (if available)TreeFam Gene Tree for ABCC4 (if available)
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Paralogsfor ABCC4 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for ABCC4 gene ABCC12 2 ABCC1 2 ABCC10 2 CFTR 2 ABCC8 2 ABCC5 2 ABCC3 2 ABCC6 2 ABCC2 2 ABCC11 2 ABCC9 2 18/22 SIMAP similar genes for ABCC4 using alignment to 4 protein entries: MRP4_HUMAN (see all proteins )
(see all similar genes ):MOAT-B TAP1 ABCB4 CTFR ABC-transporter DKFZp434I2115 DKFZp781G125 NG-TRA ABCC2 ABCC1 ABCC12 ABCC3 ABCC11 MRP3 ABCC5 ABCC9 ABCC10 ABCC6
ABCC4 for paralogs About GeneDecksing
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Genomic Variantsfor ABCC4 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 13 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for ABCC4 (95672083 - 95922083 bp, first 250kb of ABCC4)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 4 variations for ABCC4 1 CNV : 49276 3 Indels : 101823 45219 41573 Human Gene Mutation Database (HGMD) : ABCC4 SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing ABCC4
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Disorders
/ Diseasesfor ABCC4 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database , Novoseek ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
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ABCC4 for disorders About GeneDecksing
OMIM gene information: 605250
OMIM disorders : --20/34 diseases for ABCC4 (see all 34 ): About MalaCards dubin-johnson syndrome primary biliary cirrhosis lymphoblastic leukemia acute liver failure acute lymphoblastic leukemia acute myeloid leukemia cholestasis myeloid leukemia osteomalacia malignant glioma kawasaki disease bipolar disorder lung cancer ovarian carcinoma leukemia breast cancer pulmonary disease hepatocellular carcinoma pancreatitis pancreatic carcinoma 2 diseases from the University of Copenhagen DISEASES database for ABCC4 :Cholestasis Bilirubin metabolic disorder 10/11 Novoseek disease relationships for ABCC4 gene (see all 11 ) About this table
Human Genome Epidemiology (HuGE) Navigator: ABCC4 (20 documents) Export disorders for ABCC4 gene to outside databases
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Publicationsfor ABCC4 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for ABCC4 gene, integrated from 9 sources (see all 216 ): (articles sorted by number of sources associating them with ABCC4) Utopia : connect your pdf to the dynamic world of online information
Isolation of MOAT-B, a widely expressed multidrug resistance- associated protein/canalicular multispecific organic anion transporter-related transporter. (PubMed id 9661885) 1 , 2 , 3 Lee K.... Kruh G.D. (1998) Characterization of the transport of nucleoside analog drugs by the human multidrug resistance proteins MRP4 and MRP5. (PubMed id 12695538) 1 , 7, 9 Reid G....Borst P. (2003) Cotransport of reduced glutathione with bile salts by MRP4 (ABCC4) localized to the basolateral hepatocyte membrane. (PubMed id 12883481) 1 , 7, 9 Rius M....Keppler D. (2003) Expression of MRP4 confers resistance to ganciclovir and compromises bystander cell killing. (PubMed id 12105214) 1 , 2 , 9 Adachi M.... Schuetz J. (2002) The human multidrug resistance protein MRP4 functions as a prostaglandin efflux transporter and is inhibited by nonsteroidal antiinflammatory drugs. (PubMed id 12835412) 1 , 7, 9 Reid G....Borst P. (2003) MRP4: A previously unidentified factor in resistance to nucleoside-based antiviral drugs. (PubMed id 10470083) 1 , 7, 9 Schuetz J.D....Fridland A. (1999) Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines. (PubMed id 9270026) 1 , 2 , 9 Kool M.... Borst P. (1997) Human skeletal muscle drug transporters determine loc al exposure and toxicity of statins. (PubMed id 19940267) 1 , 7, 9 Knauer M.J....Tirona R.G. (2010) Multidrug resistance protein 4 (MRP4/ABCC4) mediates efflux of bimane-glutathione. (PubMed id 14643890) 1 , 7, 9 Bai J....Tan T.M. (2004) The MRP4/ABCC4 gene encodes a novel apical organic anion transporter in human kidney proximal tubules: putative efflux pump for urinary cAMP and cGMP. (PubMed id 11856762) 1 , 7, 9 van Aubel R.A....Russel F.G. (2002)
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External Searches for ABCC4 gene
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Genome Databases showing ABCC4 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
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Other Databases showing ABCC4 gene
(According to HUGE )
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Specialized Databases showing ABCC4 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for ABCC4 Pharmacogenomics, SNPs, Pathways ATLAS Chromosomes in Cancer entry for ABCC4 Genetics and Cytogenetics in Oncology and Haematology ABCMdb http://abcmutations.hegelab.org/proteinDetails?uniprot_id=O15439
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About This Section Patent Information for ABCC4 gene: Search GeneIP for patents involving ABCC4 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor ABCC4 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
OriGene Antibodies for ABCC4 OriGene shRNA RFP for ABCC4 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for ABCC4 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for ABCC4 OriGene Protein Over-expression Lysate for ABCC4 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for ABCC4 OriGene 3'-UTR Clone for ABCC4 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for ABCC4 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for ABCC4 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ABCC4 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing ABCC4 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat ABCC4 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat ABCC4 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat ABCC4 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat ABCC4
Antibodies & Assays for ABCC4  
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ABCC4 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ABCC4
ThermoFisher Antibodies for ABCC4
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat ABCC4
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