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ABCC4 Gene

protein-coding   GIFtS: 71
GCID: GC13M095672

ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 4

  See ABCC4-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 41 2     MRP/CMOAT-Related ABC Transporter2 3
MRP42 3 5     MOATB2 5
Canalicular Multispecific Organic Anion Transporter (ABC Superfamily)1 2     BA464I2.1 (ATP-Binding Cassette1
Multidrug Resistance-Associated Protein 41 2     Member 4)1
Multispecific Organic Anion Transporter B1 2     Sub-Family C (CFTR/MRP)1
Multi-Specific Organic Anion Transporter B2 3     EST1702052
MOAT-B2 3     BA464I2.1 (ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 4)2
ATP-Binding Cassette Sub-Family C Member 42 3     

External Ids:    HGNC: 551   Entrez Gene: 102572   Ensembl: ENSG000001252577   OMIM: 6052505   UniProtKB: O154393   

Export aliases for ABCC4 gene to outside databases

Previous GC identifers: GC13M094033 GC13M090059 GC13M094508 GC13M093370 GC13M094470 GC13M076269


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ABCC4 Gene:
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC
proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven
distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily
which is involved in multi-drug resistance. The specific function of this protein has not yet been determined;
however, this protein may play a role in cellular detoxification as a pump for its substrate, organic anions.
Alternative splicing results in multiple splice variants encoding different isoforms. (provided by RefSeq, Jul
2008)

GeneCards Summary for ABCC4 Gene:
ABCC4 (ATP-binding cassette, sub-family C (CFTR/MRP), member 4) is a protein-coding gene. Diseases associated with ABCC4 include lung cancer. GO annotations related to this gene include ATPase activity, coupled to transmembrane movement of substances and 15-hydroxyprostaglandin dehydrogenase (NAD+) activity. An important paralog of this gene is ABCC12.

UniProtKB/Swiss-Prot: MRP4_HUMAN, O15439
Function: May be an organic anion pump relevant to cellular detoxification

Gene Wiki entry for ABCC4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000013.10  NT_009952.15  NC_018924.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ABCC4 gene promoter:
         GR   Sp1   ATF-2   GR-beta   CUTL1   E4BP4   C/EBPalpha   c-Ets-1   N-Myc   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidABCC4 promoter sequence
   Search Chromatin IP Primers for ABCC4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ABCC4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q32   Ensembl cytogenetic band:  13q32.1   HGNC cytogenetic band: 13q31

ABCC4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ABCC4 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13M095672:  view genomic region     (about GC identifiers)

Start:
95,672,083 bp from pter      End:
95,953,687 bp from pter
Size:
281,605 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: MRP4_HUMAN, O15439 (See protein sequence)
Recommended Name: Multidrug resistance-associated protein 4  
Size: 1325 amino acids; 149527 Da
Subunit: Interacts (via PDZ-binding motif) with SNX27 (via PDZ domain)
Secondary accessions: A9Z1Z7 Q8IVZ4 Q8IZN6 Q8NEW8 Q9Y6J2
Alternative splicing: 3 isoforms:  O15439-1   O15439-2   O15439-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ABCC4: NX_O15439

Explore proteomics data for ABCC4 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys702, Lys1265, Lys1271, Lys1289
  • Glycosylation2 at Asn651, Asn690, Asn746, Asn754, Asn792, Asn1176, Asn1309
  • Modification sites at PhosphoSitePlus

  • See ABCC4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001098985.1  NP_005836.2  

    ENSEMBL proteins: 
     ENSP00000366084   ENSP00000388657   ENSP00000442024   ENSP00000398562   ENSP00000440160  
    Reactome Protein details: O15439

    ABCC4 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for ABCC4
    OriGene Custom MassSpec
    OriGene Custom Protein Services for ABCC4
    GenScript Custom Purified and Recombinant Proteins Services for ABCC4
    Novus Biologicals ABCC4 Protein
    Novus Biologicals ABCC4 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ABCC4

     
    Search eBioscience for Proteins for ABCC4 

     
    antibodies-online proteins for ABCC4 (2 products) 

     
    antibodies-online peptides for ABCC4

    ABCC4 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Cell Signaling Technology (CST) Antibodies for ABCC4 
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    Novus Biologicals ABCC4 Antibodies
    Abcam antibodies for ABCC4
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    antibodies-online antibodies for ABCC4 (68 products) 

    ABCC4 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for ABCC4
    Cloud-Clone Corp. CLIAs for ABCC4
    Search eBioscience for ELISAs for ABCC4 
    antibodies-online kits for ABCC4 (2 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ABCC: ATP binding cassette transporters / subfamily C

    IUPHAR Guide to PHARMACOLOGY protein family classification: ABCC4
    ABCC subfamily

    Selected InterPro protein domains (see all 6):
     IPR003439 ABC_transporter-like
     IPR027417 P-loop_NTPase
     IPR001140 ABC_transptr_TM_dom
     IPR003593 AAA+_ATPase
     IPR011527 ABC1_TM_dom

    Graphical View of Domain Structure for InterPro Entry O15439

    ProtoNet protein and cluster: O15439

    UniProtKB/Swiss-Prot: MRP4_HUMAN, O15439
    Similarity: Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208)
    subfamily
    Similarity: Contains 2 ABC transmembrane type-1 domains
    Similarity: Contains 2 ABC transporter domains


    Find genes that share domains with ABCC4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MRP4_HUMAN, O15439
    Function: May be an organic anion pump relevant to cellular detoxification

         Genatlas biochemistry entry for ABCC4:
    ATP binding cassette superfamily,subfamily C (CFTR/MRP),member 4

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding ----
    GO:0005524ATP binding IEA--
    GO:001640415-hydroxyprostaglandin dehydrogenase (NAD+) activity NAS7557451
    GO:0016887ATPase activity ----
    GO:0017111nucleoside-triphosphatase activity ----
         
    Find genes that share ontologies with ABCC4           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for ABCC4:
     Decreased Salmonella enterica  

         12 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Abcc4):
     behavior/neurological  cardiovascular system  digestive/alimentary  growth/size/body  hematopoietic system 
     homeostasis/metabolism  immune system  integument  mortality/aging  nervous system 
     no phenotypic analysis  renal/urinary system 

    Find genes that share phenotypes with ABCC4           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for ABCC4: Abcc4tm1Kruh Abcc4tm1Jsch

       genOway: Develop your customized and physiologically relevant rodent model for ABCC4

    miRNA
    Products:
        
    miRTarBase miRNAs that target ABCC4:
    hsa-mir-324-5p (MIRT043124), hsa-mir-23b-3p (MIRT046379), hsa-mir-125b-5p (MIRT004989), hsa-mir-16-5p (MIRT031811), hsa-mir-1 (MIRT023897), hsa-mir-155-5p (MIRT020794)

    Block miRNA regulation of human, mouse, rat ABCC4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ABCC4 (see all 29):
    hsa-miR-549 hsa-miR-3910 hsa-miR-125a-5p hsa-miR-4251 hsa-miR-539 hsa-miR-218 hsa-miR-3167 hsa-miR-1297
    SwitchGear 3'UTR luciferase reporter plasmidABCC4 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ABCC4
    Predesigned siRNA for gene silencing in human, mouse, rat ABCC4

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ABCC4

    Clone
    Products:
         
    OriGene clones in human, mouse for ABCC4 (see all 13)
    OriGene ORF clones in mouse, rat for ABCC4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ABCC4 (NM_005845)
    Sino Biological Human cDNA Clone for ABCC4
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ABCC4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ABCC4

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for ABCC4
    Browse ESI BIO Cell Lines and PureStem Progenitors for ABCC4 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ABCC4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MRP4_HUMAN, O15439: Membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol1
    endoplasmic reticulum1
    extracellular1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016020membrane IDA15297306
    GO:0016021integral component of membrane IEA--
    GO:0031088platelet dense granule membrane TAS--

    Find genes that share ontologies with ABCC4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ABCC4 About   (see all 16)  
    See pathways by source

    SuperPathContained pathways About
    1ABC-family proteins mediated transport
    ABC-family proteins mediated transport0.69
    ABC transporters0.69
    2Pyrimidine metabolism
    Fluoropyrimidine Activity0.69
    Fluoropyrimidine Pathway, Pharmacokinetics0.69
    3Response to elevated platelet cytosolic Ca2+
    Response to elevated platelet cytosolic Ca2+0.94
    Platelet degranulation0.94
    4Hemostasis
    Hemostasis0.43
    Platelet activation, signaling and aggregation0.43
    5Statin Pathway - Generalized, Pharmacokinetics
    Ibuprofen Pathway, Pharmacokinetics0.50


    Find genes that share SuperPaths with ABCC4           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for ABCC4
        Glucose / Energy Metabolism

    3 BioSystems Pathways for ABCC4
        Fluoropyrimidine Activity
    Drug Induction of Bile Acid Pathway
    Prostate Cancer


    2 Reactome Pathways for ABCC4
        ABC-family proteins mediated transport
    Platelet degranulation

    Selected PharmGKB Pathways for ABCC4 (see all 8)
        Acetaminophen Pathway, Pharmacokinetics
    Fluoropyrimidine Pathway, Pharmacokinetics
    Ibuprofen Pathway, Pharmacokinetics
    Lamivudine Pathway, Pharmacokinetics/Pharmacodynamics
    Methotrexate Pathway (Brain Cell), Pharmacokinetics

    2 Kegg Pathways  (Kegg details for ABCC4):
        ABC transporters
    Bile secretion

        Pathway & Disease-focused RT2 Profiler PCR Array including ABCC4: 
              Drug Transporters in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for ABCC4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    Selected Interacting proteins for ABCC4 (O154393 ENSP000003660844) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HAX1O001653, ENSP000003290024I2D: score=1 STRING: ENSP00000329002
    STK3Q131883I2D: score=5 
    ERBB2IPQ96RT13I2D: score=1 
    UBCENSP000003448184STRING: ENSP00000344818
    ABCB6ENSP000002653164STRING: ENSP00000265316
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002576platelet degranulation TAS--
    GO:0006810transport ----
    GO:0007596blood coagulation TAS--
    GO:0008150biological_process ND--
    GO:0030168platelet activation TAS--

    Find genes that share ontologies with ABCC4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ABCC4 (MRP4)

    Selected DrugBank Compounds for ABCC4 (see all 39)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Cyclic Adenosine Monophosphate3'-5'-cyclic adenosine monophosphate (see all 5)60-92-4transportersubstrate inhibitor11856762 12036927 11802779 11447229
    MethotrexateAmethopterin (see all 12)59-05-2transportersubstrate inhibitor11856762 12883481 11447229 14643890
    DipyridamoleDipiridamol (see all 6)58-32-2transporterinhibitor11856762 12695538 12883481
    IndomethacinIMN (see all 9)53-86-1transporterinhibitor12835412 14643890 19029202
    Probenecid-- 57-66-9transporterinhibitor11856762 12036927 12883481
    Cholic Acid-- 81-25-4transporterinhibitor12883481 14643890
    Folic AcidFolate (see all 9)59-30-3transporterinhibitor12036927 12883481
    Sildenafil-- 139755-83-2transporterinhibitor12695538 12036927
    VerapamilVerapamil [Usan:Ban:Inn] (see all 4)52-53-9transporterinhibitor12036927 14643890
    Adefovir DipivoxilAdefovir (see all 7)142340-99-6transportersubstrate10470083

    Selected Novoseek inferred chemical compound relationships for ABCC4 gene (see all 48)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mk 571 85.1 4 16132345 (1), 12695538 (1)
    adefovir 83 47 17110501 (5), 19735648 (3), 10470083 (3), 18364470 (2) (see all 12)
    probenecid 75.9 3 15504935 (2), 18930752 (1)
    sulfinpyrazone 74.3 1 15504935 (1)
    nucleoside monophosphate 69.1 3 15026196 (1), 10470083 (1), 12695538 (1)
    androstane 65.6 2 15004017 (1), 18662272 (1)
    nucleoside 63.1 20 10470083 (2), 12695538 (2), 15827327 (1), 15364914 (1) (see all 11)
    tenofovir 61.7 12 17110501 (4), 17503669 (3), 20149322 (1)
    tenofovir disoproxil fumarate 60 5 17083032 (3), 20149322 (1)
    6 thioguanine 58.7 2 11447229 (1), 12435799 (1)

    9 PharmGKB related drug/compound annotations for ABCC4 gene    About this table
    Drug/compound PharmGKB Annotation
    BisphosphonatesCA  
    cisplatinCA  
    cyclophosphamideCA  
    doxorubicinCA  
    fluorouracilCA  
    imatinibCA  
    irinotecanCA  
    tenofovirCA  
    zidovudineCA  



    Find genes that share compounds with ABCC4           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ABCC4 gene (2 alternative transcripts): 
    NM_001105515.1  NM_005845.3  

    Unigene Cluster for ABCC4:

    ATP-binding cassette, sub-family C (CFTR/MRP), member 4
    Hs.508423  [show with all ESTs]
    Unigene Representative Sequence: NM_005845
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000376887(uc001vmd.4) ENST00000484109 ENST00000471041 ENST00000474158
    ENST00000467685 ENST00000412704(uc010afj.3 uc010afk.3) ENST00000536256(uc010tih.1)
    ENST00000431522(uc001vme.2 uc010afl.1 uc010afm.1) ENST00000538287(uc001vmf.2)

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate ABCC4 (see all 29):
    hsa-miR-549 hsa-miR-3910 hsa-miR-125a-5p hsa-miR-4251 hsa-miR-539 hsa-miR-218 hsa-miR-3167 hsa-miR-1297
    SwitchGear 3'UTR luciferase reporter plasmidABCC4 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ABCC4
    Clone
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    OriGene clones in human, mouse for ABCC4 (see all 13)
    OriGene ORF clones in mouse, rat for ABCC4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ABCC4 (NM_005845)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ABCC4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ABCC4
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for ABCC4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ABCC4
      QuantiTect SYBR Green Assays in human, mouse, rat ABCC4
      QuantiFast Probe-based Assays in human, mouse, rat ABCC4

    Additional mRNA sequence: 

    AB208973.1 AF071202.1 AF071203.1 AF339763.1 AF541977.1 AK290317.1 AK296247.1 AK298953.1 
    AK309460.1 AY081219.1 AY133678.1 AY133679.1 AY133680.1 AY207008.1 BC041560.1 BX647118.1 
    U66686.1 U83660.1 

    20 DOTS entries:

    DT.115026  DT.92431917  DT.120783528  DT.99998873  DT.100764438  DT.91729507  DT.100764437  DT.120783477 
    DT.100764439  DT.40310418  DT.100651779  DT.101972277  DT.92431915  DT.97769103  DT.120783530  DT.120783536 
    DT.95374219  DT.100810521  DT.120783466  DT.40241131 

    Selected AceView cDNA sequences (see all 125):

    BM462073 W31962 BE879353 AY207008 AL699662 BX474791 N79659 BQ889997 
    BM556442 AA305627 BP382967 CF597322 CA314196 AU130197 CD657554 AI479547 
    NM_005845 BG288847 AY133680 AY133679 BP379624 BU689822 AI240818 AI301022 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ABCC4 (see all 9)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25a ·
    SP1:        -     -                                                                                                                             -           -   
    SP2:        -     -                                                                                               -                             -           -   
    SP3:        -     -                                                                                                                                             
    SP4:                                                                                                                                                            
    SP5:              -                                                                                                                                             

    ExUns: 25b ^ 26a · 26b ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35a · 35b
    SP1:                                      -                                       
    SP2:                                      -                                       
    SP3:                                                                              
    SP4:                                                                              
    SP5:                                                                              


    ECgene alternative splicing isoforms for ABCC4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ABCC4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTTCGTATTT
    ABCC4 Expression
    About this image


    ABCC4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Endothelium (Cardiovascular System)
             Mature brain microvascular endothelial cells
     
     Kidney (Urinary System)
             Metanephros
     
     Brain (Nervous System)
             Mature brain microvascular endothelial cells
    ABCC4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ABCC4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.508423

    UniProtKB/Swiss-Prot: MRP4_HUMAN, O15439
    Tissue specificity: Widely expressed, with particularly high levels in prostate, but is barely detectable in liver

        Pathway & Disease-focused RT2 Profiler PCR Array including ABCC4: 
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ABCC4 gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Abcc41 , 5 ATP-binding cassette, sub-family C (CFTR/MRP), member more1, 5 81.61(n)1
    87.09(a)1
      14 (62.24 cM)5
    2392731  NM_001033336.31  NP_001028508.21 
     1184826925 
    chicken
    (Gallus gallus)
    Aves ABCC41 ATP-binding cassette, sub-family C (CFTR/MRP), member more 74.9(n)
    78.4(a)
      418791  NM_001030819.1  NP_001025990.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    32(a)
    many ↔ many
    GL343230.1(1633266-1665146)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia abcc41 ATP-binding cassette, sub-family C (CFTR/MRP), member more 70.63(n)
    73.54(a)
      100491006  XM_002939283.2  XP_002939329.2 
    zebrafish
    (Danio rerio)
    Actinopterygii abcc41 ATP-binding cassette, sub-family C (CFTR/MRP), member more 65.9(n)
    70.25(a)
      368620  NM_001007038.1  NP_001007039.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG92703
    CG45621
    ATP-binding cassette (ABC) transporter3
    CG45621
    46(a)
    (best of 10)3
    51.88(n)1
    47.87(a)1
      38F63
    423621  NM_001275818.11  NP_001262747.11 
    worm
    (Caenorhabditis elegans)
    Secernentea mrp-61 , 3 ABC transporter3
    mrp-61
    35(a)
    (best of 2)3
    49.22(n)1
    39.98(a)1
      X(4213362-4221731)3
    1806911  NM_076309.41  NP_508710.31 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes (YKR104W)4 Putative transporter of the multidrug resistance-associated more   --   11(656836-657756) 853979  NP_013030.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons MRP31 MRP3 45.62(n)
    35.33(a)
      820496  NM_112147.2  NP_187915.1 
    rice
    (Oryza sativa)
    Liliopsida Os.332122 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 71.59(n)    NM_190319.1 


    ENSEMBL Gene Tree for ABCC4 (if available)
    TreeFam Gene Tree for ABCC4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ABCC4 gene
    ABCC122  ABCC12  ABCC82  ABCC52  ABCC62  ABCC32  ABCC22  ABCC92  
    ABCC112  
    Selected SIMAP similar genes for ABCC4 using alignment to 4 protein entries:     MRP4_HUMAN (see all proteins) (see all similar genes):
    MOAT-B    TAP1    ABCB4    CTFR    ABC-transporter    DKFZp434I2115
    DKFZp781G125    NG-TRA    ABCC2    ABCC1    ABCC12    ABCC3
    ABCC11    MRP3    ABCC5    ABCC9    ABCC10    ABCC6

    Find genes that share paralogs with ABCC4           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ABCC4 (see all 6738)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1507305111,2
    Cuntested195818586(+) TTTAGA/GAACTC 4 F syn10--------
    rs1501282461,2
    Cuntested195849477(+) ATGATA/C/TGGCTT 2 -- int10--------
    rs562982851,2
    C--76491173(+) ACACA-/CACA/CAC
    ACACACACACA
    TCTTC
    2 -- int11NA 2
    rs114583861,2
    C--76794280(+) AAAGA-/AA/G  
            
    AAGAG
    2 -- int1 trp30--------
    rs717138271,2
    C--76794281(+) AGAAA-/AG/   
       GAGAG
    GAGAA
    2 -- int10--------
    rs114352371,2
    C--76840821(+) ATAAG-/A/AA  
            
    AAAAA
    2 -- int1 trp31NA 2
    rs1399933351,2
    --95671628(+) ATCTGC/TGGTGA 1 -- ds50010--------
    rs1836623721,2
    --95671629(+) TCTGCA/GGTGAG 1 -- ds50010--------
    rs1493131101,2
    --95671674(+) TGATGC/TGGTAT 1 -- ds50010--------
    rs128698631,2
    C,F--95671701(+) CCACAC/TTTTGA 1 -- ds50017Minor allele frequency- T:0.39NA WA EA 366

    HapMap Linkage Disequilibrium report for ABCC4 (95672083 - 95922083 bp, first 250kb of ABCC4)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for ABCC4 (see all 20):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2666266CNV Deletion23128226
    esv2672928CNV Deletion23128226
    esv2747844CNV Deletion23290073
    esv2903CNV Deletion18987735
    esv2393854CNV Deletion18987734
    esv2666461CNV Deletion23128226
    esv1580429CNV Insertion17803354
    esv2530045CNV Insertion19546169
    nsv832689CNV Loss17160897
    nsv522179CNV Loss19592680

    Human Gene Mutation Database (HGMD): ABCC4
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ABCC4
    DNA2.0 Custom Variant and Variant Library Synthesis for ABCC4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605250    OMIM disorders: --

    1 disease for ABCC4:    
    About MalaCards
    lung cancer

    2 diseases from the University of Copenhagen DISEASES database for ABCC4:
    Cholestasis     Bilirubin metabolic disorder

    Find genes that share disorders with ABCC4           About GenesLikeMe

    Selected Novoseek inferred disease relationships for ABCC4 gene (see all 11)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cholestasis 64.9 3 17404579 (2), 15004017 (1)
    breast cancer 39.2 15 17682070 (2), 16393888 (1), 16565357 (1), 10739113 (1) (see all 9)
    cancer 26.9 4 9270026 (1), 16454695 (1), 17943230 (1)
    small cell lung cancer 25.1 2 10100721 (1), 12792791 (1)
    ovarian carcinoma 16.5 1 20005867 (1)
    leukemia 16.5 1 19142964 (1)
    lymphoblastic leukemia acute 11.1 1 12816874 (1)
    immunodeficiency 7.07 4 15105153 (1), 17083032 (1), 10944550 (1)
    virus infection 0 1 15105153 (1)
    cancer lung 0 3 11477564 (2)

    Genetic Association Database (GAD): ABCC4
    Human Genome Epidemiology (HuGE) Navigator: ABCC4 (20 documents)

    Export disorders for ABCC4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ABCC4 gene, integrated from 10 sources (see all 233):
    (articles sorted by number of sources associating them with ABCC4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation of MOAT-B, a widely expressed multidrug resistance- associated protein/canalicular multispecific organic anion transporter-related transporter. (PubMed id 9661885)1, 2, 3 Lee K.... Kruh G.D. (Cancer Res. 1998)
    2. The human multidrug resistance protein 4 (MRP4, ABCC4): functional analysis of a highly polymorphic gene. (PubMed id 18364470)1, 7, 9 Abla N....Kroetz D.L. (J. Pharmacol. Exp. Ther. 2008)
    3. Characterization of the transport of nucleoside analog drugs by the human multidrug resistance proteins MRP4 and MRP5. (PubMed id 12695538)1, 7, 9 Reid G....Borst P. (Mol. Pharmacol. 2003)
    4. Cotransport of reduced glutathione with bile salts by MRP4 (ABCC4) localized to the basolateral hepatocyte membrane. (PubMed id 12883481)1, 7, 9 Rius M....Keppler D. (Hepatology 2003)
    5. Expression of MRP4 confers resistance to ganciclovir and compromises bystander cell killing. (PubMed id 12105214)1, 2, 9 Adachi M.... Schuetz J. (J. Biol. Chem. 2002)
    6. The human multidrug resistance protein MRP4 functions as a prostaglandin efflux transporter and is inhibited by nonsteroidal antiinflammatory drugs. (PubMed id 12835412)1, 7, 9 Reid G....Borst P. (Proc. Natl. Acad. Sci. U.S.A. 2003)
    7. MRP4: A previously unidentified factor in resistance to nucleoside-based antiviral drugs. (PubMed id 10470083)1, 7, 9 Schuetz J.D....Fridland A. (Nat. Med. 1999)
    8. Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines. (PubMed id 9270026)1, 2, 9 Kool M.... Borst P. (Cancer Res. 1997)
    9. ATP-binding cassette C transporters in human pancreatic carcinoma cell lines. Upregulation in 5-fluorouracil-resistant cells. (PubMed id 19077464)1, 7, 9 Hagmann W....LAPhr J.M. (Pancreatology 2009)
    10. Association between ABCC2 gene haplotypes and tenofovir-induced proximal tubulopathy. (PubMed id 17083032)1, 4, 9 Izzedine H....Deray A.G. (J. Infect. Dis. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10257 HGNC: 55 AceView: ABCC4 Ensembl:ENSG00000125257 euGenes: HUgn10257
    ECgene: ABCC4 Kegg: 10257 H-InvDB: ABCC4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ABCC4 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ABCC4 Genetics and Cytogenetics in Oncology and Haematology
    ABCMdbhttp://abcmutations.hegelab.org/proteinDetails?uniprot_id=O15439

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ABCC4 gene:
    Search GeneIP for patents involving ABCC4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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