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Aliases for ABCC4 Gene

Aliases for ABCC4 Gene

  • ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 4 2 3
  • Canalicular Multispecific Organic Anion Transporter (ABC Superfamily) 2 3
  • Multi-Specific Organic Anion Transporter B 3 4
  • MRP/CMOAT-Related ABC Transporter 3 4
  • MOAT-B 3 4
  • MRP4 3 4
  • BA464I2.1 (ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 4) 3
  • ATP-Binding Cassette Sub-Family C Member 4 4
  • Multidrug Resistance-Associated Protein 4 2
  • Multispecific Organic Anion Transporter B 2
  • BA464I2.1 (ATP-Binding Cassette 2
  • Sub-Family C (CFTR/MRP) 2
  • Member 4) 2
  • MOATB 3

External Ids for ABCC4 Gene

Previous GeneCards Identifiers for ABCC4 Gene

  • GC13M094033
  • GC13M090059
  • GC13M094508
  • GC13M093370
  • GC13M094470
  • GC13M095672
  • GC13M076269

Summaries for ABCC4 Gene

Entrez Gene Summary for ABCC4 Gene

  • The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This family member plays a role in cellular detoxification as a pump for its substrate, organic anions. It may also function in prostaglandin-mediated cAMP signaling in ciliogenesis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2014]

GeneCards Summary for ABCC4 Gene

ABCC4 (ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 4) is a Protein Coding gene. Diseases associated with ABCC4 include abcc4-related altered drug metabolism and dubin-johnson syndrome. Among its related pathways are Hemostasis and Response to elevated platelet cytosolic Ca2+. GO annotations related to this gene include ATPase activity and 15-hydroxyprostaglandin dehydrogenase (NAD+) activity. An important paralog of this gene is ABCC5.

UniProtKB/Swiss-Prot for ABCC4 Gene

  • May be an organic anion pump relevant to cellular detoxification

Gene Wiki entry for ABCC4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ABCC4 Gene

Genomics for ABCC4 Gene

Regulatory Elements for ABCC4 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ABCC4 Gene

Chromosome:
13
Start:
95,019,829 bp from pter
End:
95,301,446 bp from pter
Size:
281,618 bases
Orientation:
Minus strand

Genomic View for ABCC4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ABCC4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ABCC4 Gene

Proteins for ABCC4 Gene

  • Protein details for ABCC4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15439-MRP4_HUMAN
    Recommended name:
    Multidrug resistance-associated protein 4
    Protein Accession:
    O15439
    Secondary Accessions:
    • A9Z1Z7
    • B7Z3Q7
    • Q8IVZ4
    • Q8IZN6
    • Q8NEW8
    • Q9Y6J2

    Protein attributes for ABCC4 Gene

    Size:
    1325 amino acids
    Molecular mass:
    149527 Da
    Quaternary structure:
    • Interacts (via PDZ-binding motif) with SNX27 (via PDZ domain).

    Alternative splice isoforms for ABCC4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ABCC4 Gene

Proteomics data for ABCC4 Gene at MOPED

Post-translational modifications for ABCC4 Gene

  • Ubiquitination at Lys 702, Lys 1265, Lys 1271, and Lys 1289
  • Glycosylation at Asn 651, Asn 690, Asn 746, Asn 754, Asn 792, Asn 1176, and Asn 1309
  • Modification sites at PhosphoSitePlus

Other Protein References for ABCC4 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for ABCC4 (ABCC4)

No data available for DME Specific Peptides for ABCC4 Gene

Domains & Families for ABCC4 Gene

Gene Families for ABCC4 Gene

Protein Domains for ABCC4 Gene

Graphical View of Domain Structure for InterPro Entry

O15439

UniProtKB/Swiss-Prot:

MRP4_HUMAN :
  • Contains 2 ABC transmembrane type-1 domains.
  • Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
Domain:
  • Contains 2 ABC transmembrane type-1 domains.
  • Contains 2 ABC transporter domains.
Family:
  • Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
genes like me logo Genes that share domains with ABCC4: view

Function for ABCC4 Gene

Molecular function for ABCC4 Gene

GENATLAS Biochemistry:
ATP binding cassette superfamily,subfamily C (CFTR/MRP),member 4
UniProtKB/Swiss-Prot Function:
May be an organic anion pump relevant to cellular detoxification

Gene Ontology (GO) - Molecular Function for ABCC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
GO:0016404 15-hydroxyprostaglandin dehydrogenase (NAD+) activity NAS 7557451
GO:0016887 ATPase activity --
GO:0042626 ATPase activity, coupled to transmembrane movement of substances IEA --
genes like me logo Genes that share ontologies with ABCC4: view
genes like me logo Genes that share phenotypes with ABCC4: view

Animal Models for ABCC4 Gene

MGI Knock Outs for ABCC4:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ABCC4

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for ABCC4 Gene

Localization for ABCC4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ABCC4 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ABCC4 Gene COMPARTMENTS Subcellular localization image for ABCC4 gene
Compartment Confidence
plasma membrane 5
cytosol 2
nucleus 2
extracellular 1
vacuole 1

Gene Ontology (GO) - Cellular Components for ABCC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IDA 15297306
GO:0016021 integral component of membrane IEA --
GO:0016323 basolateral plasma membrane IDA 24130369
GO:0031088 platelet dense granule membrane TAS --
genes like me logo Genes that share ontologies with ABCC4: view

Pathways & Interactions for ABCC4 Gene

genes like me logo Genes that share pathways with ABCC4: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for ABCC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002576 platelet degranulation TAS --
GO:0006810 transport --
GO:0007596 blood coagulation TAS --
GO:0008150 biological_process ND --
GO:0030168 platelet activation TAS --
genes like me logo Genes that share ontologies with ABCC4: view

No data available for SIGNOR curated interactions for ABCC4 Gene

Drugs & Compounds for ABCC4 Gene

(70) Drugs for ABCC4 Gene - From: NovoSeek, HMDB, DrugBank, ApexBio, PharmGKB, and FDA Approved Drugs

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Methotrexate Approved Pharma Transporter, substrate, inhibitor Folate antagonist,inhibits DFHR 1387
Tenofovir Approved, Investigational Pharma Transporter, substrate HIV reverse transcriptase inhibitor 636
Zidovudine Approved Pharma Transporter, substrate 489
Dipyridamole Approved Pharma Inhibition, Inhibitor, Transporter, inhibitor Adenosine transport inhibitor 75
Probenecid Approved Pharma Activator, Transporter, inhibitor 27

(18) Additional Compounds for ABCC4 Gene - From: NovoSeek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
4'-Hydroxydiclofenac
  • (O-(2,6-Dichloro-4-hydroxyanilino)phenyl)acetic acid
  • 4'-Hydroxy diclofenac
  • 4'-OH DCF
  • {2-[(2,6-dichloro-4-hydroxyphenyl)amino]phenyl}acetic acid
64118-84-9
Hydroxycelecoxib
O-Desmethylverapamil (D-702)
5fluorouracil
6 mercaptopurine
genes like me logo Genes that share compounds with ABCC4: view

Transcripts for ABCC4 Gene

Unigene Clusters for ABCC4 Gene

ATP-binding cassette, sub-family C (CFTR/MRP), member 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ABCC4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ABCC4 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25a ·
SP1: - - - -
SP2: - - - - -
SP3: - -
SP4:
SP5: -
SP6: -
SP7:
SP8:
SP9:

ExUns: 25b ^ 26a · 26b ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35a · 35b
SP1: -
SP2: -
SP3:
SP4:
SP5:
SP6:
SP7: - - -
SP8:
SP9:

Relevant External Links for ABCC4 Gene

GeneLoc Exon Structure for
ABCC4
ECgene alternative splicing isoforms for
ABCC4

Expression for ABCC4 Gene

mRNA expression in normal human tissues for ABCC4 Gene

mRNA differential expression in normal tissues according to GTEx for ABCC4 Gene

This gene is overexpressed in Bladder (x5.2).

Protein differential expression in normal tissues from HIPED for ABCC4 Gene

This gene is overexpressed in Nasal epithelium (55.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ABCC4 Gene



SOURCE GeneReport for Unigene cluster for ABCC4 Gene Hs.508423

mRNA Expression by UniProt/SwissProt for ABCC4 Gene

O15439-MRP4_HUMAN
Tissue specificity: Widely expressed, with particularly high levels in prostate, but is barely detectable in liver
genes like me logo Genes that share expression patterns with ABCC4: view

Primer Products

In Situ Assay Products

No data available for Protein tissue co-expression partners for ABCC4 Gene

Orthologs for ABCC4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ABCC4 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia ABCC4 35
  • 86.94 (n)
  • 89.43 (a)
ABCC4 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Abcc4 35
  • 81.61 (n)
  • 87.09 (a)
Abcc4 16
Abcc4 36
  • 87 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ABCC4 35
  • 99.4 (n)
  • 99.62 (a)
ABCC4 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Abcc4 35
  • 81.74 (n)
  • 86.87 (a)
cow
(Bos Taurus)
Mammalia ABCC4 36
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ABCC4 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ABCC4 36
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves ABCC4 35
  • 74.9 (n)
  • 78.4 (a)
ABCC4 36
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 32 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia abcc4 35
  • 70.63 (n)
  • 73.54 (a)
zebrafish
(Danio rerio)
Actinopterygii abcc4 35
  • 65.9 (n)
  • 70.25 (a)
abcc4 36
  • 69 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta BEST:CK01227 37
  • 42 (a)
CG10505 37
  • 39 (a)
CG11897 37
  • 39 (a)
CG11898 37
  • 35 (a)
CG4562 37
  • 43 (a)
CG5789 37
  • 42 (a)
CG7627 37
  • 44 (a)
CG7806 37
  • 31 (a)
CG9270 37
  • 46 (a)
Sur 37
  • 43 (a)
CG4562 35
  • 51.88 (n)
  • 47.87 (a)
CG31792 36
  • 41 (a)
OneToMany
CG7627 36
  • 42 (a)
OneToMany
Mrp4 36
  • 42 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006427 35
  • 51.2 (n)
  • 48.72 (a)
worm
(Caenorhabditis elegans)
Secernentea C18C4.2 37
  • 24 (a)
mrp-6 37
  • 35 (a)
mrp-6 35
  • 49.22 (n)
  • 39.98 (a)
mrp-2 36
  • 30 (a)
OneToMany
mrp-4 36
  • 30 (a)
OneToMany
mrp-7 36
  • 29 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YCF1 36
  • 32 (a)
OneToMany
-- 38
thale cress
(Arabidopsis thaliana)
eudicotyledons MRP3 35
  • 45.62 (n)
  • 35.33 (a)
rice
(Oryza sativa)
Liliopsida Os.33212 35
Os01g0173900 35
  • 44.54 (n)
  • 34.92 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 32 (a)
ManyToMany
Species with no ortholog for ABCC4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ABCC4 Gene

ENSEMBL:
Gene Tree for ABCC4 (if available)
TreeFam:
Gene Tree for ABCC4 (if available)

Paralogs for ABCC4 Gene

Paralogs for ABCC4 Gene

genes like me logo Genes that share paralogs with ABCC4: view

Variants for ABCC4 Gene

Sequence variations from dbSNP and Humsavar for ABCC4 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
VAR_046448 -
VAR_046447 -
VAR_046446 -
VAR_046445 -
VAR_045688 -

Structural Variations from Database of Genomic Variants (DGV) for ABCC4 Gene

Variant ID Type Subtype PubMed ID
nsv7246 OTHER Inversion 18451855
nsv832688 CNV Gain 17160897
nsv525194 CNV Loss 19592680
esv2530045 CNV Insertion 19546169
esv1580429 CNV Insertion 17803354
nsv832689 CNV Loss 17160897
esv2666461 CNV Deletion 23128226
nsv900925 CNV Gain 21882294
esv2672928 CNV Deletion 23128226
esv2747844 CNV Deletion 23290073
esv2393854 CNV Deletion 18987734
esv2903 CNV Deletion 18987735
nsv522179 CNV Loss 19592680
esv2666266 CNV Deletion 23128226
dgv1781n71 CNV Gain 21882294
nsv900928 CNV Gain 21882294
nsv456078 CNV Gain 19166990
nsv471169 CNV Gain 18288195
nsv517610 CNV Gain+Loss 19592680
nsv456080 CNV Gain 19166990

Variation tolerance for ABCC4 Gene

Residual Variation Intolerance Score: 33.69% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.48; 82.15% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ABCC4 Gene

HapMap Linkage Disequilibrium report
ABCC4
Human Gene Mutation Database (HGMD)
ABCC4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ABCC4 Gene

Disorders for ABCC4 Gene

MalaCards: The human disease database

(6) MalaCards diseases for ABCC4 Gene - From: GeneTests, DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
abcc4-related altered drug metabolism
  • multidrug resistance-associated protein 4
dubin-johnson syndrome
  • dubin johnson syndrome
biliary tract disease
  • biliary tract diseases
unilateral retinoblastoma
intestinal tuberculosis
  • tuberculosis of intestine
- elite association
Search ABCC4 in MalaCards View complete list of genes associated with diseases

Relevant External Links for ABCC4

Genetic Association Database (GAD)
ABCC4
Human Genome Epidemiology (HuGE) Navigator
ABCC4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ABCC4
genes like me logo Genes that share disorders with ABCC4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ABCC4 Gene

Publications for ABCC4 Gene

  1. Limited brain distribution of [3R,4R,5S]-4-acetamido-5-amino-3-(1-ethylpropoxy)-1-cyclohexene-1-carboxylate phosphate (Ro 64-0802), a pharmacologically active form of oseltamivir, by active efflux across the blood-brain barrier mediated by organic anion transporter 3 (Oat3/Slc22a8) and multidrug resistance-associated protein 4 (Mrp4/Abcc4). (PMID: 19029202) Ose A. … Sugiyama Y. (Drug Metab. Dispos. 2009) 23 25 26 67
  2. Multidrug resistance protein 4 (MRP4/ABCC4) mediates efflux of bimane-glutathione. (PMID: 14643890) Bai J. … Tan T.M. (Int. J. Biochem. Cell Biol. 2004) 23 25 26 67
  3. Cotransport of reduced glutathione with bile salts by MRP4 (ABCC4) localized to the basolateral hepatocyte membrane. (PMID: 12883481) Rius M. … Keppler D. (Hepatology 2003) 23 25 26 67
  4. Characterization of the transport of nucleoside analog drugs by the human multidrug resistance proteins MRP4 and MRP5. (PMID: 12695538) Reid G. … Borst P. (Mol. Pharmacol. 2003) 23 25 26 67
  5. The human multidrug resistance protein MRP4 functions as a prostaglandin efflux transporter and is inhibited by nonsteroidal antiinflammatory drugs. (PMID: 12835412) Reid G. … Borst P. (Proc. Natl. Acad. Sci. U.S.A. 2003) 23 25 26 67

Products for ABCC4 Gene

Sources for ABCC4 Gene

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