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ABCC4 Gene

protein-coding GIFtS: 65

GC13M094470

ATP-binding cassette, sub-family C (CFTR/MRP), member 4
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
EST170205 ^¹, ²
MOAT-B ^¹, ², ³
MOATB ^¹, ², ⁵
MRP4 ^¹, ², ³, ⁵
OTTHUMP00000018560 ^²

Descriptions
ATP-binding cassette sub-family C member 4 ^³
ATP-binding cassette, sub-family C (CFTR/MRP), member 4 ^²
ATP-binding cassette, sub-family C, member 4 ^²
MRP/cMOAT-related ABC transporter ^³
Multi-specific organic anion transporter B ^³
bA464I2.1 (ATP-binding cassette, sub-family C (CFTR/MRP), member 4) ^²
canalicular multispecific organic anion transporter (ABC superfamily) ^²
multidrug resistance-associated protein 4 ^²
multispecific organic anion transporter B ^²

External Ids
HGNC: 55¹
Entrez Gene: 10257²
UniProtKB: O15439³
Ensembl: ENSG00000125257⁷

Search outside databases for aliases for ABCC4 gene

Previous GC identifers: GC13M094033 GC13M090059 GC13M094508 GC13M093370

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for ABCC4:

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC)

transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes.

ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20,

White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance.

The specific function of this protein has not yet been determined; however, this protein may play

a role in cellular detoxification as a pump for its substrate, organic anions. Alternative

splicing results in multiple splice variants encoding different isoforms. [provided by RefSeq]

UniProtKB/Swiss-Prot: MRP4_HUMAN, O15439

Function: May be an organic anion pump relevant to cellular detoxification

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ABCC4 gene

Entrez Gene cytogenetic band: 13q32 Ensembl cytogenetic band: 13q32.1 HGNC cytogenetic band: 13q31

ABCC4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 13 GeneLoc Exon Structure

GeneLoc location for GC13M094470: (about GC identifiers)

Start:	94,470,084 bp from pter
End:	94,751,688 bp from pter
Size:	281,605 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000013.9 NT_009952.14

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: MRP4_HUMAN, O15439 (See protein sequence)

Recommended Name: Multidrug resistance-associated protein 4

Size: 1325 amino acids; 149527 Da

Subcellular location: Membrane; Multi-pass membrane protein

Secondary accessions: A9Z1Z7 Q8IZN6 Q8NEW8 Q9Y6J2

Alternative splicing: 2 isoforms: O15439-1 O15439-2

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_001098985.1 NP_005836.2

ENSEMBL proteins:

ENSP00000366084

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (MRP4)
	Human Recombinant Proteins from Abnova (ABCC4)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005575	cellular_component	ND	--
GO:0005624	membrane fraction	IDA	15297306
GO:0005886	plasma membrane	IDA	15297306
GO:0016021	integral to membrane	IEA	--
GO:0031088	platelet dense granule membrane	IDA	15297306

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Antibodies for ABCC4:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for ABCC4
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (MRP4), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (ABCC4)
	Novus Biologicals Antibodies for ABCC4

Assays for ABCC4:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry O15439

ProtoNet protein and cluster: O15439

UniProtKB/Swiss-Prot: MRP4_HUMAN, O15439

Similarity: Belongs to the ABC transporter family. Conjugate transporter (TC 3.A.1.208) subfamily

Similarity: Contains 2 ABC transmembrane type-1 domains

Similarity: Contains 2 ABC transporter domains

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ABCC4)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ABCC4)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001105515

Applied Biosystems Silencer® siRNAs for ABCC4

Sigma-Aldrich siRNA and siRNA Panels for ABCC4

Sigma-Aldrich shRNA for ABCC4

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for ABCC4
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001105515
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001105515
untagged cDNA clones in CMV expression vector (see all 2): NM_001105515

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_005845

UniProtKB/Swiss-Prot: MRP4_HUMAN, O15439

Function: May be an organic anion pump relevant to cellular detoxification

Genatlas biochemistry entry for ABCC4:

ATP binding cassette superfamily,subfamily C (CFTR/MRP),member 4

12 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Abcc4):

	behavior/neurological	digestive/alimentary	growth/size	hematopoietic system
homeostasis/metabolism	immune system	life span-post-weaning/aging	nervous system	no phenotypic analysis
renal/urinary system	touch/vibrissae

5/6 Gene Ontology (GO) molecular function terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0005254	chloride channel activity	IEA	--
GO:0005524	ATP binding	IEA	--
GO:0016404	15-hydroxyprostaglandin dehydrogenase (NAD+) activity	NAS	7557451
GO:0016887	ATPase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Sigma-Aldrich "Your Favorite Gene" Pathway for ABCC4 (Your Favorite Gene powered by Ingenuity)

LPS/IL-1 Mediated Inhibition of RXR Function

GeneDecks ABCC4 for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for ABCC4

5/17 Interacting proteins for ABCC4 (ENSP00000366084³) via UniProtKB, MINT, and/or STRING (see all 17 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
MRPS7	ENSP00000245539³	STRING (score=.892)
NR1H4	ENSP00000188403³	STRING (score=.838)
NR1I2	ENSP00000336528³	STRING (score=.835)
NR0B2	ENSP00000254227³	STRING (score=.79)
ABCG2	ENSP00000237612³	STRING (score=.777)

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2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006811	ion transport	IEA	--
GO:0008150	biological_process	ND	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for ABCC4
10/11 Novoseek chemical compound relationships for ABCC4 gene (see all 11 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
nucleoside monophosphate	70.51	3	15026196 (1), 10470083 (1), 12695538 (1)
androstane	67.88	2	15004017 (1), 18662272 (1)
nucleoside	63.87	19	10470083 (2), 12695538 (2), 15827327 (1), 15364914 (1) (see all 10)
cgmp	55.83	14	15454390 (3), 11447229 (2), 12950253 (1), 18612080 (1) (see all 8)
gamma-glutamylcysteine	33.90	2	16132345 (1)
atp	33.07	6	12883481 (2), 15297306 (1), 18593894 (1), 16265591 (1)
purine	28.76	4	11447229 (1), 11802779 (1), 17348727 (1), 15454390 (1)
txb2	15.72	2	12835412 (1), 16280858 (1)
sulfate	12.70	1	17682070 (1)
platinum	9.55	5	11477564 (2)

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7 PharmGKB drug compound relationships for ABCC4 gene

Drug compound	PharmGKB Relations	PubMed IDs for articles supporting these relationships
6-mercaptopurine	FA	12435799
6-thioguanine	FA	12435799
antivirals	FA GN	12499391
azidothymidine	FA	10470083
folic acid	FA	12036927
leucovorin	FA	12036927
methotrexate	PD FA	12036927 15630450

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(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ABCC4)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ABCC4)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001105515

Sigma-Aldrich siRNA and siRNA Panels for ABCC4

Sigma-Aldrich shRNA for ABCC4

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001105515 NM_005845

REFSEQ mRNAs for ABCC4 gene (2 alternative transcripts):

NM_001105515.1 NM_005845.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001105515 NM_005845

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001105515
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001105515
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_001105515

Additional cDNA sequence:

AB208973.1 AF071202.1 AF071203.1 AF339763.1 AF541977.1 AK290317.1 AK296247.1 AK298953.1

AK309460.1 AY081219.1 AY133678.1 AY133679.1 AY133680.1 AY207008.1 BC041560.1 BX647118.1

U66686.1 U83660.1

19 DOTS entries:

DT.115026 DT.92431917 DT.120783528 DT.99998873 DT.100764438 DT.91729507 DT.100764437 DT.120783477

DT.100764439 DT.40310418 DT.100651779 DT.101972277 DT.92431915 DT.97769103 DT.120783530 DT.120783536

DT.100810521 DT.120783466 DT.40241131

24/125 AceView cDNA sequences (see all 125 ):

BE879353 AA305627 AL699662 BM462073 N79659 BQ889997 BX474791 BP382967

W31962 AY207008 BM556442 BM968666 BX093307 BM979399 AA216367 N63981

BQ069612 AF071202 AI521738 BG288847 AY133679 AA860581 AI745633 AI470523

highest scoring ESTs for ABCC4:

AF071202 AF541977 AI948503 AY081219 AY133678 AY133679 AY133680 AY207008 BC041560 BQ069612

Unigene Cluster for ABCC4:

ATP-binding cassette, sub-family C (CFTR/MRP), member 4

Hs.508423 [show with all ESTs]

Unigene Representative Sequence: NM_005845

GeneLoc Exon Structure

5/9 Alternative Splicing Database (ASD) splice patterns (SP) for ABCC4 (see all 9 )

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14	^	15	^	16	^	17a	·	17b	^	18	^	19	^	20	^	21	^	22	^	23	^	24	^	25a	·
SP1:			-		-																																										-				-
SP2:			-		-																																-										-				-
SP3:			-		-
SP4:
SP5:					-

ExUns:	25b	^	26a	·	26b	^	27	^	28	^	29	^	30	^	31	^	32	^	33	^	34	^	35a	·	35b
SP1:													-
SP2:													-
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for ABCC4

1 Ensembl transcript including schematic representation:

ENST00000376887

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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ABCC4 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ABCC4

¹ / ² / ³

8 probe-sets matching ABCC4 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
91447_at²^{, 3}	U95-E	1	1.00	1.00	0.95	1.70	AI948503	0.80	1.00	0.91	1
72602_at²^{, 3}	U95-D	1	1.00	1.00	0.91	1.03	AI452594	0.40	1.00	0.76	1
34955_at²^{, 3}	U95-A	1	1.00	1.00	0.98	0.80	AF071202	1.00	1.00	1.00	1
1931_at²^{, 3}	U95-A	1	1.00	1.00	0.90	0.56	U83660	0.80	1.00	0.91	1
203196_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AI948503	0.80	1.00	0.91	1
1555039_a_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1554918_a_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
203196_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks ABCC4 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
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About these images

CGAP SAGE TAG: GTTCGTATTT

SOURCE GeneReport for Unigene cluster: Hs.508423
Expression variation in blood from EXPOLDB for ABCC4
UniProtKB/Swiss-Prot: MRP4_HUMAN, O15439
Tissue specificity: Widely expressed, with particularly high levels in prostate, but is barely
detectable in liver

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for ABCC4 gene from 5/12 species (see all 12 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ABCC4¹	--	ATP-binding cassette, sub-family C (CFTR/MRP), member more	86.92(n) 89.36(a)	485523 XM_542642.2 XP_542642.2
chimpanzee (Pan troglodytes)	ABCC4¹	--	ATP-binding cassette, sub-family C (CFTR/MRP), member more	99.4(n) 99.62(a)	452625 XM_001137006.1 XP_001137006.1
cow (Bos taurus)	ABCC4¹	--	ATP-binding cassette, sub-family C (CFTR/MRP), member more	86.94(n) 89.89(a)	515333 XM_593336.3 XP_593336.2
rat (Rattus norvegicus)	Abcc4¹	--	ATP-binding cassette, sub-family C (CFTR/MRP), member more	81.74(n) 86.87(a)	170924 NM_133411.1 NP_596902.1
mouse (Mus musculus)	Abcc4^{1, 5}	14⁵	ATP-binding cassette, sub-family C (CFTR/MRP), member more^{1, 5}	81.58(n)¹ 87.02(a)¹	239273¹ NM_001033336.2¹ NP_001028508.1¹ AK032802⁵ AK052778⁵ (see all 9)

About this table Species with no ortholog for ABCC4

ENSEMBL Gene Tree for ABCC4

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for ABCC4 gene

ABCC5²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/2667 NCBI SNPs in ABCC4 are shown (see all 2667 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 826)

AB	SNP ID	Valid	Chr 13 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
--	rs869951^1,2	A,C,F,O	94752211(+)	`AACGAG/CGGTGC`	2	--	ng3¹		10	MN EU EA WA	2334
	rs1059751^1,2	A,C,F,H	94470951(-)	`TTGACT/CGTAAG`	1	--	ut3¹ ese³		17	EA MN EU WA NA	3068
	rs9516519^1,2	A,C,F,H	94470458(+)	`ACATCT/GGTTGC`	1	--	ut3¹ ese³		7	NA EU EA WA	560
	rs9516520^1,2	A,C,F,H	94470859(+)	`ATGCTT/CGCAAT`	1	--	ut3¹ ese³		8	NA EU EA WA	652
	rs4148551^1,2	A,C,F,H	94471519(-)	`GGACAG/AAGTTG`	1	--	ut3¹ ese³		9	NA MN EA EU WA	906
	rs6650282^1,2	A,C,F,H	94546222(+)	`ATATTT/CAATTG`	2	--	int¹ ut3¹		7	EU EA WA NA	560
	rs4148553^1,2	A,C,F,H	94471136(-)	`CTGAAG/AGACAC`	1	--	ut3¹ ese³		18	EU EA WA NA MN	1824
	rs868853^1,2	A,C,F,H	94753077(-)	`ATAAAA/GTAAGG`	2	--	ng3¹		7	NA EA EU WA	668
	rs9282570^1,2	C,F,H	94613455(-)	`AAAGTA/GTGCTA`	2	M/V	mis¹ ese³		15	MN CSAM EA EU WA NA	1872
	rs3742106^1,2	C,F,H	94471792(+)	`AGTGGA/CAAATG`	1	--	ut3¹ ese³		21	EA NA EU WA	3764

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HapMap Linkage Disequilibrium images for ABCC4 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 605250

10 Novoseek disease relationships for ABCC4 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
cholestasis	65.21	3	17404579 (2), 15004017 (1)
breast cancer	38.22	15	17682070 (2), 16393888 (1), 16565357 (1), 10739113 (1) (see all 9)
small cell lung cancer	27.59	2	10100721 (1), 12792791 (1)
cancer	26.99	4	9270026 (1), 16454695 (1), 17943230 (1)
leukemia	19.29	1	19142964 (1)
immunodeficiency	9.85	4	15105153 (1), 17083032 (1), 10944550 (1)
lymphoblastic leukemia acute	0.56	1	12816874 (1)
cancer lung	0.00	3	11477564 (2)
tumors	0.00	4	16393888 (1), 16565357 (1), 15688370 (1), 11477564 (1)
virus infection	0.00	1	15105153 (1)

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2 PharmGKB disease relationships for ABCC4 gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
HIV	FA	10470083
Leukemia, Lymphocytic, Acute, L1	PD	15630450

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Human Gene Mutation Database: ABCC4
Human Genome Epidemiology Navigator: ABCC4 (5 documents)

(Possibly Related Articles in Doctor's Guide)
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(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/154 PubMed articles for ABCC4 gene (see all 154 ):

Nonsense mediated decay downregulates conserved alternatively spliced ABCC4 transcripts bearing nonsense codons. (PubMed id 12499391)^{1, 3, 7} Lamba J.K....Schuetz J.D. (2003)
MRP4: A previously unidentified factor in resistance to nucleoside-based antiviral drugs. (PubMed id 10470083)^{1, 3, 7} Schuetz J.D....Fridland A. (1999)
Isolation of MOAT-B, a widely expressed multidrug resistance-associated protein/canalicular multispecific organic anion transporter-related transporter. (PubMed id 9661885)^{2, 3, 4} Lee K....Kruh G.D. (1998)
Expression of MRP4 confers resistance to ganciclovir and compromises bystander cell killing. (PubMed id 12105214)^{1, 3, 4} Adachi M.... Schuetz J. (2002)
Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines. (PubMed id 9270026)^{1, 3, 4} Kool M.... Borst P. (1997)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{3, 4} Olsen J.V....Mann M. (2006)
Thiopurine metabolism and identification of the thiopurine metabolites transported by MRP4 and MRP5 overexpressed in human embryonic kidney cells. (PubMed id 12435799)^{1, 7} Wielinga P.R....Borst P. (2002)
Characterization of the human ABC superfamily: isolation and mapping of 21 new genes using the expressed sequence tags database. (PubMed id 8894702)^{2, 3} Allikmets R....Dean M. (1996)
The human multidrug resistance protein 4 (MRP4, ABCC4): functional analysis of a highly polymorphic gene. (PubMed id 18364470)^{1, 3} Abla N....Kroetz D.L. (2008)
Characterization of the transport of nucleoside analog drugs by the human multidrug resistance proteins MRP4 and MRP5. (PubMed id 12695538)^{1, 3} Reid G....Borst P. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 10257	HGNC: 55	AceView: ABCC4	Ensembl:ENSG00000125257	euGenes: HUgn10257
ECgene: ABCC4	H-InvDB: ABCC4

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for ABCC4	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for ABCC4
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for ABCC4:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ABCC4-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ABCC4		Antibodies for ABCC4
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for ABCC4		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (ABCC4)
	Antibodies (ABCC4)
	Chimera RNAi (ABCC4)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (MRP4)
	Antibodies (MRP4)

Search OriGene for ABCC4

Search Tocris compounds for ABCC4

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for ABCC4

GeneCards Homepage - Last full update: 1 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
ABCC4 Gene at Home site.
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ABCC4 Gene

protein-coding GIFtS: 65

Aliases &
Descriptions
for ABCC4

Summaries
for ABCC4

Genomic Location
for ABCC4

Proteins
for ABCC4

Protein Domains/
Families
for ABCC4

Gene Function
for ABCC4

Pathways & Interactions
for ABCC4

Drugs & Compounds
for ABCC4

Transcripts
for ABCC4

Expression
for ABCC4

Orthologs
for ABCC4

Paralogs
for ABCC4

SNPs/Variants
for ABCC4

Disorders & Mutations
for ABCC4

Medical News
for ABCC4

Publications
for ABCC4

Search for ABCC4

Genome Databases showing ABCC4

Other Databases showing ABCC4

Specialized Databases showing ABCC4

Licensable Technologies
for ABCC4

Services
for ABCC4

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ABCC4 Gene

protein-coding GIFtS: 65

Aliases & Descriptionsfor ABCC4

Summariesfor ABCC4

Genomic Locationfor ABCC4

Proteinsfor ABCC4

Protein Domains/Familiesfor ABCC4

Gene Functionfor ABCC4

Pathways & Interactionsfor ABCC4

Drugs & Compoundsfor ABCC4

Transcriptsfor ABCC4

Expression for ABCC4

Orthologsfor ABCC4

Paralogsfor ABCC4

SNPs/Variantsfor ABCC4

Disorders & Mutationsfor ABCC4

Medical Newsfor ABCC4

Publicationsfor ABCC4

Search for ABCC4

Genome Databases showing ABCC4

Other Databases showing ABCC4

Specialized Databases showing ABCC4

Licensable Technologiesfor ABCC4

Servicesfor ABCC4

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ABCC4

Summaries
for ABCC4

Genomic Location
for ABCC4

Proteins
for ABCC4

Protein Domains/
Families
for ABCC4

Gene Function
for ABCC4

Pathways & Interactions
for ABCC4

Drugs & Compounds
for ABCC4

Transcripts
for ABCC4

Expression
for ABCC4

Orthologs
for ABCC4

Paralogs
for ABCC4

SNPs/Variants
for ABCC4

Disorders & Mutations
for ABCC4

Medical News
for ABCC4

Publications
for ABCC4

Licensable Technologies
for ABCC4

Services
for ABCC4