Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ABCC4 Gene

protein-coding GIFtS: 66
GCID: GC13M095672

ATP-binding cassette, sub-family C (CFTR/MRP), member 4

Explore 34 diseases affiliated with
ABCC4 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 4¹ ²		ATP-Binding Cassette Sub-Family C Member 4² ³
MRP4¹ ² ³ ⁵		MRP/CMOAT-Related ABC Transporter² ³
MOAT-B¹ ² ³		BA464I2.1 (ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 4)²
MOATB¹ ² ⁵		Canalicular Multispecific Organic Anion Transporter (ABC Superfamily)²
EST170205¹ ²		Multidrug Resistance-Associated Protein 4²
Multi-Specific Organic Anion Transporter B² ³		Multispecific Organic Anion Transporter B²

External Ids:	HGNC: 55¹	Entrez Gene: 10257²	Ensembl: ENSG00000125257⁷	OMIM: 605250⁵	UniProtKB: O15439³

Export aliases for ABCC4 gene to outside databases

Previous GC identifers: GC13M094033 GC13M090059 GC13M094508 GC13M093370 GC13M094470 GC13M076269

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ABCC4:

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC

proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven

distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily

which is involved in multi-drug resistance. The specific function of this protein has not yet been determined;

however, this protein may play a role in cellular detoxification as a pump for its substrate, organic anions.

Alternative splicing results in multiple splice variants encoding different isoforms. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: MRP4_HUMAN, O15439

Function: May be an organic anion pump relevant to cellular detoxification

Gene Wiki entry for ABCC4

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000013.10 NC_018924.1 NT_009952.14

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ABCC4 gene promoter:
GR Sp1 ATF-2 GR-beta CUTL1 E4BP4 C/EBPalpha c-Ets-1 N-Myc GR-alpha
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ABCC4 promoter sequence

Search SABiosciences Chromatin IP Primers for ABCC4

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ABCC4

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q32 Ensembl cytogenetic band: 13q32.1 HGNC cytogenetic band: 13q31

ABCC4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ABCC4 gene location

GeneLoc information about chromosome 13 GeneLoc Exon Structure

GeneLoc location for GC13M095672: view genomic region (about GC identifiers)

Start:	95,672,083 bp from pter	End:	95,953,687 bp from pter
Size:	281,605 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MRP4_HUMAN, O15439 (See protein sequence)

Recommended Name: Multidrug resistance-associated protein 4

Size: 1325 amino acids; 149527 Da

Subcellular location: Membrane; Multi-pass membrane protein

Secondary accessions: A9Z1Z7 Q8IVZ4 Q8IZN6 Q8NEW8 Q9Y6J2

Alternative splicing: 3 isoforms: O15439-1 O15439-2 O15439-3 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ABCC4: NX_O15439

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O15439

ABCC4 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001098985.1 NP_005836.2

ENSEMBL proteins:

ENSP00000366084 ENSP00000388657 ENSP00000442024 ENSP00000398562 ENSP00000440160

Reactome Protein details: O15439
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: ABCC4 OriGene Custom Protein Services for ABCC4
	GenScript Custom Purified and Recombinant Proteins Services for ABCC4
	Novus Biologicals ABCC4 Protein Novus Biologicals ABCC4 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for ABCC4

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	TAS	--
GO:0016020	membrane	IDA	15297306
GO:0016021	integral to membrane	IEA	--
GO:0031088	platelet dense granule membrane	TAS	--

ABCC4 for ontologies About GeneDecksing

ABCC4 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for ABCC4
	OriGene Antibodies: ABCC4 OriGene Custom Antibody Services for ABCC4
	GenScript Custom Superior Antibodies Services for ABCC4
	Novus Biologicals ABCC4 Antibodies
	Search for Antibodies for ABCC4 at Abcam
	Uscn Antibodies for ABCC4
	ThermoFisher Antibodies for ABCC4

Assay Products for ABCC4:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for ABCC4
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for ABCC4

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ABCC4 for domains About GeneDecksing

5/6 InterPro domains/families (see all 6):

IPR003439 ABC_transporter-like

IPR001140 ABC_transptr_TM_dom

IPR003593 AAA+_ATPase

IPR017940 ABC_transporter_type1

IPR011527 ABC_transptrTM_dom_typ1

Graphical View of Domain Structure for InterPro Entry O15439

ProtoNet protein and cluster: O15439

UniProtKB/Swiss-Prot: MRP4_HUMAN, O15439

Similarity: Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily

Similarity: Contains 2 ABC transmembrane type-1 domains

Similarity: Contains 2 ABC transporter domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: MRP4_HUMAN, O15439

Function: May be an organic anion pump relevant to cellular detoxification

Genatlas biochemistry entry for ABCC4:

ATP binding cassette superfamily,subfamily C (CFTR/MRP),member 4

miRNA Products:		miRTarBase miRNAs that target ABCC4: hsa-mir-125b (MIRT004989)

		OriGene 3'-UTR Clone (see all 2): ABCC4 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ABCC4
		8/29 QIAGEN miScript miRNA Assays for microRNAs that regulate ABCC4 (see all 29):
		hsa-miR-549 hsa-miR-3910 hsa-miR-125a-5p hsa-miR-4251 hsa-miR-539 hsa-miR-218 hsa-miR-3167 hsa-miR-1297

		SwitchGear 3'UTR luciferase reporter plasmid: ABCC4 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ABCC4 (see all 7) OriGene shRNA RFP: ABCC4 OriGene siRNA: ABCC4
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ABCC4

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for ABCC4

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ABCC4 (see all 6) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ABCC4 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): ABCC4 (NM_005845)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ABCC4
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ABCC4

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for ABCC4
		Search LifeMap BioReagents cell lines for ABCC4

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ABCC4

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005524	ATP binding	IEA	--
GO:0016404	15-hydroxyprostaglandin dehydrogenase (NAD+) activity	NAS	7557451
GO:0042626	ATPase activity, coupled to transmembrane movement of substances	IEA	--

ABCC4 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for ABCC4:

Decreased Salmonella enterica

Animal Models:
Mouse knock-outs for ABCC4: Abcc4^tm1Kruh Abcc4^tm1Jsch
12 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Abcc4):

behavior/neurological	cardiovascular system	digestive/alimentary	growth/size	hematopoietic system
homeostasis/metabolism	immune system	integument	mortality/aging	nervous system
no phenotypic analysis	renal/urinary system

ABCC4 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/14 super-pathways (see all 14) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Platelet activation, signaling and aggregation

Platelet activation, signaling and aggregation

1.00

Hemostasis

0.43

Platelet degranulation

Platelet degranulation

1.00

Response to elevated platelet cytosolic Ca2+

0.94

Acetaminophen Pathway, Pharmacokinetics

Pathway_PA165986194 -need delete

1.00

Acetaminophen Pathway, Pharmacokinetics

1.00

Fluoropyrimidine Activity

Fluoropyrimidine Activity

1.00

Fluoropyrimidine Pathway, Pharmacokinetics

0.73

ABC-family proteins mediated transport

ABC-family proteins mediated transport

1.00

ABC transporters

0.70

Pathway sources
See GeneCards unified pathways
Show all pathways

1 Cell Signaling Technology (CST) Pathway for ABCC4

Glucose / Energy Metabolism

2 BioSystems Pathways for ABCC4

	Fluoropyrimidine Activity
	Drug Induction of Bile Acid Pathway

5/6 Reactome Pathways for ABCC4 (see all 6)

	ABC-family proteins mediated transport
	Hemostasis
	Transmembrane transport of small molecules
	Platelet degranulation
	Platelet activation, signaling and aggregation

5/9 PharmGKB Pathways for ABCC4 (see all 9)

	Acetaminophen Pathway, Pharmacokinetics
	Fluoropyrimidine Pathway, Pharmacokinetics
	Lamivudine Pathway, Pharmacokinetics/Pharmacodynamics
	Methotrexate Pathway (Brain Cell), Pharmacokinetics
	Methotrexate Pathway (Cancer Cell), Pharmacodynamics

2 Kegg Pathways (Kegg details for ABCC4):

	ABC transporters
	Bile secretion

ABCC4 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for ABCC4

STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

4 Interacting proteins for ABCC4 (O15439³ ENSP00000366084⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
HAX1	O00165³, ENSP00000329002⁴	I2D: score=1 STRING: ENSP00000329002
STK3	Q13188³	I2D: score=5
ERBB2IP	Q96RT1³	I2D: score=1
UBC	ENSP00000344818⁴	STRING: ENSP00000344818

About this table

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002576	platelet degranulation	TAS	--
GO:0007596	blood coagulation	TAS	--
GO:0008150	biological_process	ND	--
GO:0030168	platelet activation	TAS	--
GO:0055085	transmembrane transport	TAS	--

ABCC4 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

ABCC4 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ABCC4

10/34 DrugBank Compounds for ABCC4 (see all 34) About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Cyclic Adenosine Monophosphate	3'-5'-cyclic adenosine monophosphate (see all 5)	60-92-4	transporter	substrate inhibitor	11856762 12036927 11802779 11447229
Methotrexate	Amethopterin (see all 12)	59-05-2	transporter	substrate inhibitor	11856762 12883481 11447229 14643890
Dipyridamole	Dipiridamol (see all 6)	58-32-2	transporter	inhibitor	11856762 12695538 12883481
Indomethacin	IMN (see all 9)	53-86-1	transporter	inhibitor	12835412 14643890 19029202
Probenecid	Probenecid Acid (see all 2)	57-66-9	transporter	inhibitor	11856762 12036927 12883481
Cholic Acid	--	81-25-4	transporter	inhibitor	12883481 14643890
Folic Acid	Folate (see all 9)	59-30-3	transporter	inhibitor	12036927 12883481
Sildenafil	--	139755-83-2	transporter	inhibitor	12695538 12036927
Verapamil	Verapamil [Usan:Ban:Inn] (see all 4)	52-53-9	transporter	inhibitor	12036927 14643890
Adefovir Dipivoxil	Adefovir (see all 7)	142340-99-6	transporter	substrate	10470083

10/48 Novoseek chemical compound relationships for ABCC4 gene (see all 48) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
mk 571	85.1	4	16132345 (1), 12695538 (1)
adefovir	83	47	17110501 (5), 19735648 (3), 10470083 (3), 18364470 (2) (see all 12)
probenecid	75.9	3	15504935 (2), 18930752 (1)
sulfinpyrazone	74.3	1	15504935 (1)
nucleoside monophosphate	69.1	3	15026196 (1), 10470083 (1), 12695538 (1)
androstane	65.6	2	15004017 (1), 18662272 (1)
nucleoside	63.1	20	10470083 (2), 12695538 (2), 15827327 (1), 15364914 (1) (see all 11)
tenofovir	61.7	12	17110501 (4), 17503669 (3), 20149322 (1)
tenofovir disoproxil fumarate	60	5	17083032 (3), 20149322 (1)
6 thioguanine	58.7	2	11447229 (1), 12435799 (1)

4 PharmGKB related drug/compound annotations for ABCC4 gene

Drug/compound	PharmGKB Annotation
cyclophosphamide	CA
doxorubicin	CA
fluorouracil	CA
tenofovir	CA

About this table

Search CenterWatch for drugs/clinical trials and news about ABCC4 / MRP4

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ABCC4 gene (2 alternative transcripts):

NM_001105515.1 NM_005845.3

Unigene Cluster for ABCC4:

ATP-binding cassette, sub-family C (CFTR/MRP), member 4

Hs.508423 [show with all ESTs]

Unigene Representative Sequence: NM_005845

9 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000376887(uc001vmd.4) ENST00000484109 ENST00000471041 ENST00000474158

ENST00000467685 ENST00000412704(uc010afj.3 uc010afk.3) ENST00000536256(uc010tih.1)

ENST00000431522(uc001vme.2 uc010afl.1 uc010afm.1) ENST00000538287(uc001vmf.2)

miRNA Products:		OriGene 3'-UTR Clone (see all 2): ABCC4 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ABCC4
		8/29 QIAGEN miScript miRNA Assays for microRNAs that regulate ABCC4 (see all 29):
		hsa-miR-549 hsa-miR-3910 hsa-miR-125a-5p hsa-miR-4251 hsa-miR-539 hsa-miR-218 hsa-miR-3167 hsa-miR-1297

		SwitchGear 3'UTR luciferase reporter plasmid: ABCC4 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ABCC4 (see all 7) OriGene shRNA RFP: ABCC4 OriGene siRNA: ABCC4
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ABCC4

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ABCC4 (see all 6) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ABCC4 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): ABCC4 (NM_005845)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ABCC4
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ABCC4

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ABCC4 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat ABCC4
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ABCC4
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ABCC4

Additional cDNA sequence:

AB208973.1 AF071202.1 AF071203.1 AF339763.1 AF541977.1 AK290317.1 AK296247.1 AK298953.1

AK309460.1 AY081219.1 AY133678.1 AY133679.1 AY133680.1 AY207008.1 BC041560.1 BX647118.1

U66686.1 U83660.1

20 DOTS entries:

DT.115026 DT.92431917 DT.120783528 DT.99998873 DT.100764438 DT.91729507 DT.100764437 DT.120783477

DT.100764439 DT.40310418 DT.100651779 DT.101972277 DT.92431915 DT.97769103 DT.120783530 DT.120783536

DT.95374219 DT.100810521 DT.120783466 DT.40241131

24/125 AceView cDNA sequences (see all 125):

AL699662 BX474791 BM556442 BM462073 BP382967 BQ889997 W31962 N79659

AA305627 AY207008 BE879353 BE552099 BM553694 AA860581 Z45397 AA216367

AA035221 AF339763 N63981 CF597322 AI419629 BM979399 AI470523 AA229426

GeneLoc Exon Structure

5/9 Alternative Splicing Database (ASD) splice patterns (SP) for ABCC4 (see all 9) About this scheme

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14	^	15	^	16	^	17a	·	17b	^	18	^	19	^	20	^	21	^	22	^	23	^	24	^	25a	·
SP1:			-		-																																										-				-
SP2:			-		-																																-										-				-
SP3:			-		-
SP4:
SP5:					-

ExUns:	25b	^	26a	·	26b	^	27	^	28	^	29	^	30	^	31	^	32	^	33	^	34	^	35a	·	35b
SP1:													-
SP2:													-
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for ABCC4

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ABCC4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTTCGTATTT

About this image

ABCC4 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 3 LifeMap Cells

Name

Category

PureStem™ progenitor EN27 (Embryonic Progenitor Cell)

Mature brain microvascular endothelial cells (Derivation of blood-...)

Definitive endoderm-like cells (A scalable, suspensi...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See ABCC4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ABCC4

SOURCE GeneReport for Unigene cluster: Hs.508423

UniProtKB/Swiss-Prot: MRP4_HUMAN, O15439

Tissue specificity: Widely expressed, with particularly high levels in prostate, but is barely detectable in liver

SABiosciences Expression via Pathway-Focused PCR Array including ABCC4:

Drug Transporters in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ABCC4 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat ABCC4
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ABCC4
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ABCC4

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ABCC4

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for ABCC4 gene from 6/22 species (see all 22) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	ABCC4¹	ATP-binding cassette, sub-family C (CFTR/MRP), member more	74.9(n) 78.4(a)		418791 NM_001030819.1 NP_001025990.1
lizard (Anolis carolinensis)	Reptilia	ABCC4⁶	--	72(a)	1 ↔ 1	3(85023613-85193849)
zebrafish (Danio rerio)	Actinopterygii	abcc4¹	ATP-binding cassette, sub-family C (CFTR/MRP), member more	65.83(n) 70.1(a)		368620 NM_001007038.1 NP_001007039.1
fruit fly (Drosophila melanogaster)	Insecta	CG9270³ CG4562¹	ATP-binding cassette (ABC) transporter³ CG4562¹	46(a) (best of 10)³ 51.43(n)¹ 46.81(a)¹		38F6³ 42362¹ NM_142581.1¹ NP_650838.1¹
worm (Caenorhabditis elegans)	Secernentea	mrp-6^{1 , 3}	ABC transporter³ Protein MRP-6¹	35(a) (best of 2)³ 48.99(n)¹ 39.31(a)¹		X(4213362-4221731)³ 180691¹ NM_076309.3¹ NP_508710.2¹
rice (Oryza sativa)	Liliopsida	Os.33212²	Oryza sativa (japonica cultivar-group) cDNA cloneJ more	71.59(n)		NM_190319.1

ENSEMBL Gene Tree for ABCC4 (if available)
TreeFam Gene Tree for ABCC4 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ABCC4 gene

ABCC12² ABCC1² ABCC10² CFTR² ABCC8² ABCC5² ABCC3² ABCC6²

ABCC2² ABCC11² ABCC9²

18/22 SIMAP similar genes for ABCC4 using alignment to 4 protein entries: MRP4_HUMAN (see all proteins) (see all similar genes):

MOAT-B TAP1 ABCB4 CTFR ABC-transporter DKFZp434I2115

DKFZp781G125 NG-TRA ABCC2 ABCC1 ABCC12 ABCC3

ABCC11 MRP3 ABCC5 ABCC9 ABCC10 ABCC6

ABCC4 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 13 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs150128246^1,2	C,	unknown	95849477(+)	`ATGATA/C/TGGCTT`	2	--	int¹		0	--	--	--	--
rs150730511^1,2	C,	other	95818586(+)	`TTTAGA/GAACTC`	4	F	syn¹		0	--	--	--	--
rs139993335^1,2		--	95671628(+)	`ATCTGC/TGGTGA`	1	--	ds500¹		0	--	--	--	--
rs183662372^1,2		--	95671629(+)	`TCTGCA/GGTGAG`	1	--	ds500¹		0	--	--	--	--
rs149313110^1,2		--	95671674(+)	`TGATGC/TGGTAT`	1	--	ds500¹		0	--	--	--	--
rs12869863^1,2	C,F,	--	95671701(+)	`CCACAC/TTTTGA`	1	--	ds500¹		7		NA WA EA	366
rs144549606^1,2		--	95671929(+)	`CTACCC/TGTTAG`	1	--	ds500¹		0	--	--	--	--
rs114788085^1,2	F,	--	95671936(+)	`TTAGAA/GTACTT`	1	--	ds500¹		1		WA	118
rs116626593^1,2	C,F,	--	95671967(+)	`AGAACC/TGGTTG`	1	--	ds500¹		1		WA	118
rs187965117^1,2		--	95671968(+)	`GAACCA/GGTTGA`	1	--	ds500¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for ABCC4 (95672083 - 95922083 bp, first 250kb of ABCC4)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for ABCC4
1 CNV: 49276
3 Indels: 101823 45219 41573
Human Gene Mutation Database (HGMD): ABCC4

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ABCC4

DNA2.0 Custom Variant and Variant Library Synthesis for ABCC4

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ABCC4 for disorders           About GeneDecksing

OMIM gene information: 605250    OMIM disorders: --

20/34 diseases for ABCC4 (see all 34):    About MalaCards

dubin-johnson syndrome primary biliary cirrhosis lymphoblastic leukemia acute liver failure

acute lymphoblastic leukemia acute myeloid leukemia cholestasis myeloid leukemia

osteomalacia malignant glioma kawasaki disease bipolar disorder

lung cancer ovarian carcinoma leukemia breast cancer

pulmonary disease hepatocellular carcinoma pancreatitis pancreatic carcinoma

2 diseases from the University of Copenhagen DISEASES database for ABCC4:

Cholestasis Bilirubin metabolic disorder

10/11 Novoseek disease relationships for ABCC4 gene (see all 11) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
cholestasis	64.9	3	17404579 (2), 15004017 (1)
breast cancer	39.2	15	17682070 (2), 16393888 (1), 16565357 (1), 10739113 (1) (see all 9)
cancer	26.9	4	9270026 (1), 16454695 (1), 17943230 (1)
small cell lung cancer	25.1	2	10100721 (1), 12792791 (1)
ovarian carcinoma	16.5	1	20005867 (1)
leukemia	16.5	1	19142964 (1)
lymphoblastic leukemia acute	11.1	1	12816874 (1)
immunodeficiency	7.07	4	15105153 (1), 17083032 (1), 10944550 (1)
virus infection	0	1	15105153 (1)
cancer lung	0	3	11477564 (2)

Human Genome Epidemiology (HuGE) Navigator: ABCC4 (20 documents)

Export disorders for ABCC4 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ABCC4 gene, integrated from 9 sources (see all 216):
(articles sorted by number of sources associating them with ABCC4)

Utopia: connect your pdf to the dynamic
world of online information

Isolation of MOAT-B, a widely expressed multidrug resistance- associated protein/canalicular multispecific organic anion transporter-related transporter. (PubMed id 9661885)^{1, 2, 3} Lee K.... Kruh G.D. (1998)
Characterization of the transport of nucleoside analog drugs by the human multidrug resistance proteins MRP4 and MRP5. (PubMed id 12695538)^{1, 7, 9} Reid G....Borst P. (2003)
Cotransport of reduced glutathione with bile salts by MRP4 (ABCC4) localized to the basolateral hepatocyte membrane. (PubMed id 12883481)^{1, 7, 9} Rius M....Keppler D. (2003)
Expression of MRP4 confers resistance to ganciclovir and compromises bystander cell killing. (PubMed id 12105214)^{1, 2, 9} Adachi M.... Schuetz J. (2002)
The human multidrug resistance protein MRP4 functions as a prostaglandin efflux transporter and is inhibited by nonsteroidal antiinflammatory drugs. (PubMed id 12835412)^{1, 7, 9} Reid G....Borst P. (2003)
MRP4: A previously unidentified factor in resistance to nucleoside-based antiviral drugs. (PubMed id 10470083)^{1, 7, 9} Schuetz J.D....Fridland A. (1999)
Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines. (PubMed id 9270026)^{1, 2, 9} Kool M.... Borst P. (1997)
Human skeletal muscle drug transporters determine loc al exposure and toxicity of statins. (PubMed id 19940267)^{1, 7, 9} Knauer M.J....Tirona R.G. (2010)
Multidrug resistance protein 4 (MRP4/ABCC4) mediates efflux of bimane-glutathione. (PubMed id 14643890)^{1, 7, 9} Bai J....Tan T.M. (2004)
The MRP4/ABCC4 gene encodes a novel apical organic anion transporter in human kidney proximal tubules: putative efflux pump for urinary cAMP and cGMP. (PubMed id 11856762)^{1, 7, 9} van Aubel R.A....Russel F.G. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 10257	HGNC: 55	AceView: ABCC4	Ensembl:ENSG00000125257	euGenes: HUgn10257
ECgene: ABCC4	Kegg: 10257	H-InvDB: ABCC4

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ABCC4	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for ABCC4	Genetics and Cytogenetics in Oncology and Haematology
ABCMdb	http://abcmutations.hegelab.org/proteinDetails?uniprot_id=O15439

Intellectual Property for ABCC4 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for ABCC4 gene:
Search GeneIP for patents involving ABCC4

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	OriGene Antibodies for ABCC4		OriGene shRNA RFP for ABCC4
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ABCC4		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ABCC4
	OriGene Protein Over-expression Lysate for ABCC4		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for ABCC4		OriGene 3'-UTR Clone for ABCC4
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ABCC4		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ABCC4
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for ABCC4		OriGene Custom Protein Services for ABCC4
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ABCC4
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ABCC4
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ABCC4
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ABCC4
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ABCC4
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ABCC4

	GenScript Custom Purified and Recombinant Proteins Services for ABCC4		GenScript cDNA clones with any tag delivered in your preferred vector for ABCC4
	GenScript Custom Assay Services for ABCC4		GenScript Custom Superior Antibodies Services for ABCC4
	GenScript Custom overexpressing Cell Line Services for ABCC4		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Antibodies & Assays for ABCC4

	Regulatory tfbs in ABCC4 promoter
	Search Chromatin IP Primers for ABCC4
	RT² qPCR Primer Assay in human, mouse, rat ABCC4
	GNC Network for ABCC4
	SABiosciences PCR Arrays including human, mouse, rat ABCC4

Search Tocris compounds for ABCC4

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	ABCC4 antibodies
	ABCC4 proteins
	ABCC4 lysates

	Search for Antibodies for ABCC4 at Abcam
	See all of Abcam's Antibodies, Kits and Proteins for ABCC4
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

ABCC4 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for ABCC4

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ABCC4

	SwitchGear 3'UTR luciferase reporter plasmids for ABCC4
	SwitchGear Promoter luciferase reporter plasmids for ABCC4

ThermoFisher Antibodies for ABCC4

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ABCC4

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes ABCC4 gene at Home site.

hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

ABCC4 Gene

ATP-binding cassette, sub-family C (CFTR/MRP), member 4

Aliases
for ABCC4 gene

Summaries
for ABCC4 gene

Genomic Views
for ABCC4 gene

Proteins
for ABCC4 gene

Protein Domains /
Families
for ABCC4 gene

Function
for ABCC4 gene

Pathways & Interactions
for ABCC4 gene

Drugs & Compounds
for ABCC4 gene

Transcripts
for ABCC4 gene

Expression
for ABCC4 gene

Orthologs
for ABCC4 gene

Paralogs
for ABCC4 gene

Genomic Variants
for ABCC4 gene

Disorders / Diseases
for ABCC4 gene

Publications
for ABCC4 gene

External Searches for ABCC4 gene

Genome Databases showing ABCC4 gene

Other Databases showing ABCC4 gene

Specialized Databases showing ABCC4 gene

Intellectual Property
for ABCC4 gene

Products
for ABCC4 gene

View Random Gene

Advanced Search

Export list of displayed genes

ABCC4 Gene

ATP-binding cassette, sub-family C (CFTR/MRP), member 4

Aliasesfor ABCC4 gene

Summariesfor ABCC4 gene

Genomic Viewsfor ABCC4 gene

Proteinsfor ABCC4 gene

Protein Domains /Familiesfor ABCC4 gene

Functionfor ABCC4 gene

Pathways & Interactionsfor ABCC4 gene

Drugs & Compoundsfor ABCC4 gene

Transcriptsfor ABCC4 gene

Expression for ABCC4 gene

Orthologsfor ABCC4 gene

Paralogsfor ABCC4 gene

Genomic Variantsfor ABCC4 gene

Disorders / Diseasesfor ABCC4 gene

Publicationsfor ABCC4 gene

External Searches for ABCC4 gene

Genome Databases showing ABCC4 gene

Other Databases showing ABCC4 gene

Specialized Databases showing ABCC4 gene

Intellectual Propertyfor ABCC4 gene

Productsfor ABCC4 gene

View Random Gene

Aliases
for ABCC4 gene

Summaries
for ABCC4 gene

Genomic Views
for ABCC4 gene

Proteins
for ABCC4 gene

Protein Domains /
Families
for ABCC4 gene

Function
for ABCC4 gene

Pathways & Interactions
for ABCC4 gene

Drugs & Compounds
for ABCC4 gene

Transcripts
for ABCC4 gene

Expression
for ABCC4 gene

Orthologs
for ABCC4 gene

Paralogs
for ABCC4 gene

Genomic Variants
for ABCC4 gene

Disorders / Diseases
for ABCC4 gene

Publications
for ABCC4 gene

Intellectual Property
for ABCC4 gene

Products
for ABCC4 gene