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ABCC4 Gene

protein-coding   GIFtS: 65

GC13M094470
ATP-binding cassette, sub-family C (CFTR/MRP), member 4
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
EST170205 1, 2
MOAT-B 1, 2, 3
MOATB 1, 2, 5
MRP4 1, 2, 3, 5
OTTHUMP00000018560 2
Descriptions
ATP-binding cassette sub-family C member 4 3
ATP-binding cassette, sub-family C (CFTR/MRP), member 4 2
ATP-binding cassette, sub-family C, member 4 2
MRP/cMOAT-related ABC transporter 3
Multi-specific organic anion transporter B 3
bA464I2.1 (ATP-binding cassette, sub-family C (CFTR/MRP),
member 4) 2
canalicular multispecific organic anion transporter (ABC
superfamily) 2
multidrug resistance-associated protein 4 2
multispecific organic anion transporter B 2
External Ids
HGNC: 551
Entrez Gene: 102572
UniProtKB: O154393
Ensembl: ENSG000001252577
Search outside databases for aliases for ABCC4 gene

Previous GC identifers: GC13M094033 GC13M090059 GC13M094508 GC13M093370

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for ABCC4:
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC)
transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes.
ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20,
White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance.
The specific function of this protein has not yet been determined; however, this protein may play
a role in cellular detoxification as a pump for its substrate, organic anions. Alternative
splicing results in multiple splice variants encoding different isoforms. [provided by RefSeq]

UniProtKB/Swiss-Prot: MRP4_HUMAN, O15439
Function: May be an organic anion pump relevant to cellular detoxification

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the ABCC4 gene  

Entrez Gene cytogenetic band: 13q32   Ensembl cytogenetic band:  13q32.1   HGNC cytogenetic band: 13q31

ABCC4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13M094470:     (about GC identifiers)

Start:
94,470,084 bp from pter
End:
94,751,688 bp from pter
Size:
281,605 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000013.9  NT_009952.14  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: MRP4_HUMAN, O15439 (See protein sequence)
Recommended Name: Multidrug resistance-associated protein 4  
Size: 1325 amino acids; 149527 Da
Subcellular location: Membrane; Multi-pass membrane protein
Secondary accessions: A9Z1Z7 Q8IZN6 Q8NEW8 Q9Y6J2
Alternative splicing: 2 isoforms:  O15439-1   O15439-2   

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins (2 alternative transcripts): 
    NP_001098985.1  NP_005836.2  


    ENSEMBL proteins: 
    ENSP00000366084 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (MRP4)
    Human Recombinant Proteins from Abnova (ABCC4)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    5 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575 cellular_component ND--
    GO:0005624 membrane fraction IDA15297306
    GO:0005886 plasma membrane IDA15297306
    GO:0016021 integral to membrane IEA--
    GO:0031088 platelet dense granule membrane IDA15297306
    About this table

    Antibodies for ABCC4: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for ABCC4
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (MRP4), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (ABCC4)
    Novus Biologicals Antibodies for ABCC4

    Assays for ABCC4: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    5/6 InterPro domains/families (see all 6 ):
     IPR009147 CysFib_conduc_TM
     IPR003593 ATPase_AAA+_core
     IPR003439 ABC_transporter-like
     IPR017940 ABC_transporter_type1
     IPR001140 ABC_TM_transpt


       GeneDecks  ABCC4 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry O15439

    ProtoNet protein and cluster: O15439

    UniProtKB/Swiss-Prot: MRP4_HUMAN, O15439
    Similarity: Belongs to the ABC transporter family. Conjugate transporter (TC 3.A.1.208) subfamily
    Similarity: Contains 2 ABC transmembrane type-1 domains
    Similarity: Contains 2 ABC transporter domains

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (ABCC4)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (ABCC4)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001105515

                  Applied Biosystems Silencer® siRNAs for ABCC4

                  Sigma-Aldrich siRNA and siRNA Panels for ABCC4  
                         Sigma-Aldrich shRNA for ABCC4  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for ABCC4
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001105515
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001105515
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_001105515 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_005845

    UniProtKB/Swiss-Prot: MRP4_HUMAN, O15439
    Function: May be an organic anion pump relevant to cellular detoxification

    Genatlas biochemistry entry for ABCC4:
    ATP binding cassette superfamily,subfamily C (CFTR/MRP),member 4

    12 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Abcc4):

    behavior/neurologicaldigestive/alimentarygrowth/sizehematopoietic system
    homeostasis/metabolismimmune systemlife span-post-weaning/agingnervous systemno phenotypic analysis
    renal/urinary systemtouch/vibrissae

    5/6 Gene Ontology (GO) molecular function terms (links to tree view) (see all 6 ):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166 nucleotide binding IEA--
    GO:0005254 chloride channel activity IEA--
    GO:0005524 ATP binding IEA--
    GO:0016404 15-hydroxyprostaglandin dehydrogenase (NAD+) activity NAS7557451
    GO:0016887 ATPase activity IEA--
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


    1 Sigma-Aldrich "Your Favorite Gene" Pathway for  ABCC4  (Your Favorite Gene powered by Ingenuity) 
     LPS/IL-1 Mediated Inhibition of RXR Function

       GeneDecks  ABCC4 for the pathways selected above  
    About GeneDecksing

    1 Kegg Pathway  (Kegg details for ABCC4):
     hsa02010 ABC transporters

       GeneDecks  ABCC4 for the pathways selected above  
    About GeneDecksing
     Gene Network CentralTM Interacting Genes and Proteins Network for  ABCC4 


    5/17 Interacting proteins for ABCC4 (ENSP000003660843) via UniProtKB, MINT, and/or STRING (see all 17 )
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MRPS7ENSP000002455393STRING (score=.892)
    NR1H4ENSP000001884033STRING (score=.838)
    NR1I2ENSP000003365283STRING (score=.835)
    NR0B2ENSP000002542273STRING (score=.79)
    ABCG2ENSP000002376123STRING (score=.777)
    About this table

    2 Gene Ontology (GO) biological process terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006811 ion transport IEA--
    GO:0008150 biological_process ND--
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for ABCC4
    10/11 Novoseek chemical compound relationships for ABCC4 gene (see all 11 )
    Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    nucleoside monophosphate 70.51 3 15026196 (1), 10470083 (1), 12695538 (1)
    androstane 67.88 2 15004017 (1), 18662272 (1)
    nucleoside 63.87 19 10470083 (2), 12695538 (2), 15827327 (1), 15364914 (1) (see all 10)
    cgmp 55.83 14 15454390 (3), 11447229 (2), 12950253 (1), 18612080 (1) (see all 8)
    gamma-glutamylcysteine 33.90 2 16132345 (1)
    atp 33.07 6 12883481 (2), 15297306 (1), 18593894 (1), 16265591 (1)
    purine 28.76 4 11447229 (1), 11802779 (1), 17348727 (1), 15454390 (1)
    txb2 15.72 2 12835412 (1), 16280858 (1)
    sulfate 12.70 1 17682070 (1)
    platinum 9.55 5 11477564 (2)
    About this table

    7 PharmGKB drug compound relationships for ABCC4 gene
    Drug compound PharmGKB Relations PubMed IDs for articles supporting these relationships
    6-mercaptopurineFA  12435799
    6-thioguanineFA  12435799
    antiviralsFA  GN  12499391
    azidothymidineFA  10470083
    folic acidFA  12036927
    leucovorinFA  12036927
    methotrexatePD  FA  12036927 15630450
    About this table


    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (ABCC4)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (ABCC4)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001105515

                  Sigma-Aldrich siRNA and siRNA Panels for ABCC4  
                         Sigma-Aldrich shRNA for ABCC4  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_001105515  NM_005845  

    REFSEQ mRNAs for ABCC4 gene (2 alternative transcripts): 

    NM_001105515.1   NM_005845.3   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_001105515  NM_005845  

                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001105515
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001105515
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_001105515 

    Additional cDNA sequence: 

    AB208973.1 AF071202.1 AF071203.1 AF339763.1 AF541977.1 AK290317.1 AK296247.1 AK298953.1 
    AK309460.1 AY081219.1 AY133678.1 AY133679.1 AY133680.1 AY207008.1 BC041560.1 BX647118.1 
    U66686.1 U83660.1 

    19 DOTS entries:

    DT.115026  DT.92431917  DT.120783528  DT.99998873  DT.100764438  DT.91729507  DT.100764437  DT.120783477 
    DT.100764439  DT.40310418  DT.100651779  DT.101972277  DT.92431915  DT.97769103  DT.120783530  DT.120783536 
    DT.100810521  DT.120783466  DT.40241131 

    24/125 AceView cDNA sequences (see all 125 ):

    BE879353 AA305627 AL699662 BM462073 N79659 BQ889997 BX474791 BP382967 
    W31962 AY207008 BM556442 BM968666 BX093307 BM979399 AA216367 N63981 
    BQ069612 AF071202 AI521738 BG288847 AY133679 AA860581 AI745633 AI470523 

    highest scoring ESTs for ABCC4:

    AF071202 AF541977 AI948503 AY081219 AY133678 AY133679 AY133680 AY207008 BC041560 BQ069612 

    Unigene Cluster for ABCC4:

    ATP-binding cassette, sub-family C (CFTR/MRP), member 4
    Hs.508423  [show with all ESTs]
    Unigene Representative Sequence: NM_005845


    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for ABCC4 (see all 9 )

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25a ·
    SP1:        -     -                                                                                                                             -           -   
    SP2:        -     -                                                                                               -                             -           -   
    SP3:        -     -                                                                                                                                             
    SP4:                                                                                                                                                            
    SP5:              -                                                                                                                                             

    ExUns: 25b ^ 26a · 26b ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35a · 35b
    SP1:                                      -                                       
    SP2:                                      -                                       
    SP3:                                                                              
    SP4:                                                                              
    SP5:                                                                              

    About this scheme

    ECgene alternative splicing isoforms for ABCC4

    1 Ensembl transcript including schematic representation:
    ENST00000376887  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    ABCC4 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for ABCC4

    1 / 2 / 3

    8 probe-sets matching ABCC4 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    91447_at2, 3 U95-E 1 1.00 1.00 0.95 1.70 AI948503 0.80 1.00 0.91 1
    72602_at2, 3 U95-D 1 1.00 1.00 0.91 1.03 AI452594 0.40 1.00 0.76 1
    34955_at2, 3 U95-A 1 1.00 1.00 0.98 0.80 AF071202 1.00 1.00 1.00 1

    1931_at2, 3 U95-A 1 1.00 1.00 0.90 0.56 U83660 0.80 1.00 0.91 1

    203196_at2, 3 U133-A 1 1.00 1.00 -- -- AI948503 0.80 1.00 0.91 1

    1555039_a_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    1554918_a_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    203196_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    GeneDecks  ABCC4 for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: GTTCGTATTT

    SOURCE GeneReport for Unigene cluster: Hs.508423

    Expression variation in blood from EXPOLDB for ABCC4

    UniProtKB/Swiss-Prot: MRP4_HUMAN, O15439
    Tissue specificity: Widely expressed, with particularly high levels in prostate, but is barely
    detectable in liver

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for ABCC4 gene from 5/12 species (see all 12 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    ABCC41   -- ATP-binding cassette, sub-family C (CFTR/MRP), member more 86.92(n)
    89.36(a)
    485523  XM_542642.2  XP_542642.2 
    chimpanzee
    (Pan troglodytes)
    ABCC41   -- ATP-binding cassette, sub-family C (CFTR/MRP), member more 99.4(n)
    99.62(a)
    452625  XM_001137006.1  XP_001137006.1 
    cow
    (Bos taurus)
    ABCC41   -- ATP-binding cassette, sub-family C (CFTR/MRP), member more 86.94(n)
    89.89(a)
    515333  XM_593336.3  XP_593336.2 
    rat
    (Rattus norvegicus)
    Abcc41   -- ATP-binding cassette, sub-family C (CFTR/MRP), member more 81.74(n)
    86.87(a)
    170924  NM_133411.1  NP_596902.1 
    mouse
    (Mus musculus)
    Abcc41, 5 145
    ATP-binding cassette, sub-family C (CFTR/MRP), member more1, 5 81.58(n)1
    87.02(a)1
    2392731  NM_001033336.21  NP_001028508.11 
     AK0328025  AK0527785  (see all 9)
    About this table        Species with no ortholog for ABCC4

    ENSEMBL Gene Tree for ABCC4
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for ABCC4 gene
    ABCC52  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/2667 NCBI SNPs in ABCC4 are shown (see all 2667 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 826)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 13 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    --
    rs8699511,2
    A,C,F,O94752211(+) AACGAG/CGGTGC 2 -- ng3110Minor allele frequency- C:0.44MN EU EA WA 2334
    rs10597511,2
    A,C,F,H94470951(-) TTGACT/CGTAAG 1 -- ut31 ese317Minor allele frequency- C:0.47EA MN EU WA NA 3068
    rs95165191,2
    A,C,F,H94470458(+) ACATCT/GGTTGC 1 -- ut31 ese37Minor allele frequency- G:0.03NA EU EA WA 560
    rs95165201,2
    A,C,F,H94470859(+) ATGCTT/CGCAAT 1 -- ut31 ese38Minor allele frequency- C:0.05NA EU EA WA 652
    rs41485511,2
    A,C,F,H94471519(-) GGACAG/AAGTTG 1 -- ut31 ese39Minor allele frequency- A:0.49NA MN EA EU WA 906
    rs66502821,2
    A,C,F,H94546222(+) ATATTT/CAATTG 2 -- int1 ut317Minor allele frequency- C:0.46EU EA WA NA 560
    rs41485531,2
    A,C,F,H94471136(-) CTGAAG/AGACAC 1 -- ut31 ese318Minor allele frequency- A:0.42EU EA WA NA MN 1824
    rs8688531,2
    A,C,F,H94753077(-) ATAAAA/GTAAGG 2 -- ng317Minor allele frequency- G:0.16NA EA EU WA 668
    rs92825701,2
    C,F,H94613455(-) AAAGTA/GTGCTA 2 M/V mis1 ese315Minor allele frequency- G:0.01MN CSAM EA EU WA NA 1872
    rs37421061,2
    C,F,H94471792(+) AGTGGA/CAAATG 1 -- ut31 ese321Minor allele frequency- C:0.44EA NA EU WA 3764
    About this table

    HapMap Linkage Disequilibrium images for ABCC4 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 605250

    10 Novoseek disease relationships for ABCC4 gene

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    cholestasis 65.21 3 17404579 (2), 15004017 (1)
    breast cancer 38.22 15 17682070 (2), 16393888 (1), 16565357 (1), 10739113 (1) (see all 9)
    small cell lung cancer 27.59 2 10100721 (1), 12792791 (1)
    cancer 26.99 4 9270026 (1), 16454695 (1), 17943230 (1)
    leukemia 19.29 1 19142964 (1)
    immunodeficiency 9.85 4 15105153 (1), 17083032 (1), 10944550 (1)
    lymphoblastic leukemia acute 0.56 1 12816874 (1)
    cancer lung 0.00 3 11477564 (2)
    tumors 0.00 4 16393888 (1), 16565357 (1), 15688370 (1), 11477564 (1)
    virus infection 0.00 1 15105153 (1)
    About this table

    2 PharmGKB disease relationships for ABCC4 gene
    Disease PharmGKB Relations PubMed IDs for articles supporting these relationships
    HIVFA  10470083
    Leukemia, Lymphocytic, Acute, L1PD  15630450
    About this table

    Human Gene Mutation Database: ABCC4
    Human Genome Epidemiology Navigator: ABCC4 (5 documents)

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/154 PubMed articles for ABCC4 gene (see all 154 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 10257 HGNC: 55 AceView: ABCC4 Ensembl:ENSG00000125257 euGenes: HUgn10257
    ECgene: ABCC4 H-InvDB: ABCC4
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

    NameDescription
    ATLAS Chromosomes in Cancer entry for ABCC4 Genetics and Cytogenetics in Oncology and Haematology
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



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