Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ABCC4 Gene

Aliases for ABCC4 Gene

  • ATP Binding Cassette Subfamily C Member 4 2 3 5
  • Canalicular Multispecific Organic Anion Transporter (ABC Superfamily) 2 3
  • BA464I2.1 (ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 4) 2 3
  • Multi-Specific Organic Anion Transporter B 3 4
  • Multidrug Resistance-Associated Protein 4 2 3
  • MRP/CMOAT-Related ABC Transporter 3 4
  • MOAT-B 3 4
  • MRP4 3 4
  • ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 4 2
  • ATP-Binding Cassette Sub-Family C Member 4 4
  • Multispecific Organic Anion Transporter B 2
  • MOATB 3

External Ids for ABCC4 Gene

Previous GeneCards Identifiers for ABCC4 Gene

  • GC13M094033
  • GC13M090059
  • GC13M094508
  • GC13M093370
  • GC13M094470
  • GC13M095672
  • GC13M076269

Summaries for ABCC4 Gene

Entrez Gene Summary for ABCC4 Gene

  • The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This family member plays a role in cellular detoxification as a pump for its substrate, organic anions. It may also function in prostaglandin-mediated cAMP signaling in ciliogenesis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2014]

GeneCards Summary for ABCC4 Gene

ABCC4 (ATP Binding Cassette Subfamily C Member 4) is a Protein Coding gene. Diseases associated with ABCC4 include Abcc4-Related Altered Drug Metabolism and Biliary Tract Disease. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling. GO annotations related to this gene include ATPase activity and 15-hydroxyprostaglandin dehydrogenase (NAD+) activity. An important paralog of this gene is ABCC2.

UniProtKB/Swiss-Prot for ABCC4 Gene

  • May be an organic anion pump relevant to cellular detoxification.

Gene Wiki entry for ABCC4 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ABCC4 Gene

Genomics for ABCC4 Gene

Regulatory Elements for ABCC4 Gene

Enhancers for ABCC4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH13G095265 1.8 FANTOM5 Ensembl ENCODE dbSUPER 21.8 +30.0 29997 11.7 HDGF PKNOX1 FOXA2 CREB3L1 ARNT SIN3A FEZF1 ZNF766 FOS ZNF592 ABCC4 LOC102724149 GC13M095121
GH13G095297 1.9 FANTOM5 Ensembl ENCODE dbSUPER 12.7 +1.5 1531 5.6 HDGF FOXA2 CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ABCC4 LOC102724149 GC13M095121
GH13G095253 1 ENCODE dbSUPER 21.3 +45.8 45814 3.5 TBP JUN ZNF140 SIN3A FOSL1 GATA2 ZNF366 SCRT2 RCOR1 ZNF600 ABCC4 LOC102724149 GC13M095121
GH13G095201 1.2 FANTOM5 ENCODE 16.5 +99.1 99115 1.1 HDAC1 PKNOX1 ATF1 TCF12 GATA2 SIRT6 CREM CEBPB NFIC SMARCA4 ABCC4 GC13M095121 LOC102724149
GH13G095191 1 Ensembl ENCODE 19.4 +108.9 108865 2.0 CTCF RB1 EBF1 ZIC2 RAD21 RELA EED PATZ1 ZNF143 SMC3 ABCC4 GC13M095121 LOC102724149
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ABCC4 on UCSC Golden Path with GeneCards custom track

Promoters for ABCC4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000064658 246 1601 HDGF ATF1 CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 GLIS2 GATA2

Genomic Location for ABCC4 Gene

Chromosome:
13
Start:
95,019,829 bp from pter
End:
95,301,446 bp from pter
Size:
281,618 bases
Orientation:
Minus strand

Genomic View for ABCC4 Gene

Genes around ABCC4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ABCC4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ABCC4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ABCC4 Gene

Proteins for ABCC4 Gene

  • Protein details for ABCC4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15439-MRP4_HUMAN
    Recommended name:
    Multidrug resistance-associated protein 4
    Protein Accession:
    O15439
    Secondary Accessions:
    • A9Z1Z7
    • B7Z3Q7
    • Q8IVZ4
    • Q8IZN6
    • Q8NEW8
    • Q9Y6J2

    Protein attributes for ABCC4 Gene

    Size:
    1325 amino acids
    Molecular mass:
    149527 Da
    Quaternary structure:
    • Interacts (via PDZ-binding motif) with SNX27 (via PDZ domain).

    Alternative splice isoforms for ABCC4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ABCC4 Gene

Post-translational modifications for ABCC4 Gene

  • Ubiquitination at Lys702, posLast=12651265, Lys1271, and posLast=12891289
  • Glycosylation at Asn651, posLast=690690, Asn746, Asn754, Asn792, Asn1176, and Asn1309
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ABCC4 Gene

Domains & Families for ABCC4 Gene

Gene Families for ABCC4 Gene

Graphical View of Domain Structure for InterPro Entry

O15439

UniProtKB/Swiss-Prot:

MRP4_HUMAN :
  • Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
Family:
  • Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
genes like me logo Genes that share domains with ABCC4: view

Function for ABCC4 Gene

Molecular function for ABCC4 Gene

GENATLAS Biochemistry:
ATP binding cassette superfamily,subfamily C (CFTR/MRP),member 4
UniProtKB/Swiss-Prot Function:
May be an organic anion pump relevant to cellular detoxification.

Gene Ontology (GO) - Molecular Function for ABCC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism TAS --
GO:0016404 15-hydroxyprostaglandin dehydrogenase (NAD+) activity NAS 7557451
GO:0016887 ATPase activity IEA --
GO:0042626 ATPase activity, coupled to transmembrane movement of substances IBA --
genes like me logo Genes that share ontologies with ABCC4: view
genes like me logo Genes that share phenotypes with ABCC4: view

Animal Models for ABCC4 Gene

MGI Knock Outs for ABCC4:

Animal Model Products

  • Taconic Biosciences Mouse Models for ABCC4

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ABCC4 Gene

Localization for ABCC4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ABCC4 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ABCC4 gene
Compartment Confidence
plasma membrane 5
nucleus 3
cytosol 2
extracellular 1
peroxisome 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for ABCC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane IEA,IDA 15297306
GO:0016021 integral component of membrane IEA --
GO:0016323 basolateral plasma membrane IDA 24130369
genes like me logo Genes that share ontologies with ABCC4: view

Pathways & Interactions for ABCC4 Gene

genes like me logo Genes that share pathways with ABCC4: view

Gene Ontology (GO) - Biological Process for ABCC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002576 platelet degranulation TAS --
GO:0006810 transport IEA --
GO:0008150 biological_process ND --
GO:0010033 response to organic substance IEA --
GO:0010243 response to organonitrogen compound IEA --
genes like me logo Genes that share ontologies with ABCC4: view

No data available for SIGNOR curated interactions for ABCC4 Gene

Drugs & Compounds for ABCC4 Gene

(75) Drugs for ABCC4 Gene - From: DrugBank, PharmGKB, ApexBio, FDA Approved Drugs, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Methotrexate Approved Pharma Transporter, substrate, inhibitor Folate antagonist,inhibits DFHR 1551
Mercaptopurine Approved Pharma Transporter, substrate 0
Tenofovir Approved, Investigational Pharma Transporter, substrate HIV reverse transcriptase inhibitor 759
Zidovudine Approved Pharma Transporter, substrate 495
Dipyridamole Approved Pharma Inhibition, Inhibitor, Transporter, inhibitor Adenosine transport inhibitor 83

(17) Additional Compounds for ABCC4 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
4'-Hydroxydiclofenac
  • (O-(2,6-Dichloro-4-hydroxyanilino)phenyl)acetic acid
  • 4'-Hydroxy diclofenac
  • 4'-OH DCF
  • {2-[(2,6-dichloro-4-hydroxyphenyl)amino]phenyl}acetic acid
64118-84-9
Hydroxycelecoxib
O-Desmethylverapamil (D-702)

(1) ApexBio Compounds for ABCC4 Gene

Compound Action Cas Number
PTC124 (Ataluren) CFTR-G542X nonsense allele inhibitor 775304-57-9
genes like me logo Genes that share compounds with ABCC4: view

Drug Products

Transcripts for ABCC4 Gene

Unigene Clusters for ABCC4 Gene

ATP-binding cassette, sub-family C (CFTR/MRP), member 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ABCC4 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25a ·
SP1: - - - -
SP2: - - - - -
SP3: - -
SP4:
SP5: -
SP6: -
SP7:
SP8:
SP9:

ExUns: 25b ^ 26a · 26b ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35a · 35b
SP1: -
SP2: -
SP3:
SP4:
SP5:
SP6:
SP7: - - -
SP8:
SP9:

Relevant External Links for ABCC4 Gene

GeneLoc Exon Structure for
ABCC4
ECgene alternative splicing isoforms for
ABCC4

Expression for ABCC4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ABCC4 Gene

mRNA differential expression in normal tissues according to GTEx for ABCC4 Gene

This gene is overexpressed in Bladder (x5.2).

Protein differential expression in normal tissues from HIPED for ABCC4 Gene

This gene is overexpressed in Nasal epithelium (55.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ABCC4 Gene



NURSA nuclear receptor signaling pathways regulating expression of ABCC4 Gene:

ABCC4

SOURCE GeneReport for Unigene cluster for ABCC4 Gene:

Hs.508423

mRNA Expression by UniProt/SwissProt for ABCC4 Gene:

O15439-MRP4_HUMAN
Tissue specificity: Widely expressed, with particularly high levels in prostate, but is barely detectable in liver.

Evidence on tissue expression from TISSUES for ABCC4 Gene

  • Kidney(4.6)
  • Nervous system(4.5)
  • Blood(3)
  • Liver(2.9)
  • Stomach(2.5)
  • Intestine(2.2)
genes like me logo Genes that share expression patterns with ABCC4: view

Primer Products

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ABCC4 Gene

Orthologs for ABCC4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ABCC4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ABCC4 34 35
  • 99.4 (n)
cow
(Bos Taurus)
Mammalia ABCC4 35
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ABCC4 34 35
  • 86.94 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ABCC4 35
  • 82 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Abcc4 34
  • 81.74 (n)
mouse
(Mus musculus)
Mammalia Abcc4 34 16 35
  • 81.61 (n)
oppossum
(Monodelphis domestica)
Mammalia ABCC4 35
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves ABCC4 35 34
  • 74.9 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 32 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia abcc4 34
  • 70.63 (n)
zebrafish
(Danio rerio)
Actinopterygii abcc4 34 35
  • 65.9 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG4562 36 34
  • 51.88 (n)
CG9270 36
  • 46 (a)
CG7627 36 35
  • 44 (a)
Sur 36
  • 43 (a)
BEST:CK01227 36
  • 42 (a)
CG5789 36
  • 42 (a)
Mrp4 35
  • 42 (a)
OneToMany
CG31792 35
  • 41 (a)
OneToMany
CG10505 36
  • 39 (a)
CG11897 36
  • 39 (a)
CG11898 36
  • 35 (a)
CG7806 36
  • 31 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006427 34
  • 51.2 (n)
worm
(Caenorhabditis elegans)
Secernentea mrp-6 36 34
  • 49.22 (n)
mrp-2 35
  • 30 (a)
OneToMany
mrp-4 35
  • 30 (a)
OneToMany
mrp-7 35
  • 29 (a)
OneToMany
C18C4.2 36
  • 24 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YCF1 35
  • 32 (a)
OneToMany
-- 37
thale cress
(Arabidopsis thaliana)
eudicotyledons MRP3 34
  • 45.62 (n)
rice
(Oryza sativa)
Liliopsida Os01g0173900 34
  • 44.54 (n)
Os.33212 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 32 (a)
ManyToMany
Species where no ortholog for ABCC4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ABCC4 Gene

ENSEMBL:
Gene Tree for ABCC4 (if available)
TreeFam:
Gene Tree for ABCC4 (if available)

Paralogs for ABCC4 Gene

Paralogs for ABCC4 Gene

genes like me logo Genes that share paralogs with ABCC4: view

Variants for ABCC4 Gene

Sequence variations from dbSNP and Humsavar for ABCC4 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs1751034 drug-response 95,062,722(+) GACAT(C/T)TTCTT reference, synonymous-codon
rs193921134 Uncertain significance 95,177,789(-) GAGCA(G/T)TGTAT reference, missense
rs781305510 Uncertain significance 95,083,154(+) CCAGG(A/C/G)GCTTC reference, missense
rs1000004254 -- 95,279,739(+) GCTGA(C/T)CCCAG intron-variant
rs1000007264 -- 95,105,508(+) AGAAG(A/T)TAATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ABCC4 Gene

Variant ID Type Subtype PubMed ID
dgv1731n100 CNV gain 25217958
dgv3327n54 CNV gain 21841781
dgv575e212 CNV gain 25503493
esv1580429 CNV insertion 17803354
esv2393854 CNV deletion 18987734
esv2530045 CNV insertion 19546169
esv2666266 CNV deletion 23128226
esv2666461 CNV deletion 23128226
esv2672928 CNV deletion 23128226
esv2747844 CNV deletion 23290073
esv2903 CNV loss 18987735
esv3336662 CNV insertion 20981092
esv3427279 CNV duplication 20981092
esv3432022 CNV duplication 20981092
esv3550918 CNV deletion 23714750
esv3633238 CNV loss 21293372
esv3633239 CNV loss 21293372
esv3633240 CNV loss 21293372
esv3633241 CNV loss 21293372
esv3633242 CNV loss 21293372
nsv1043019 CNV gain 25217958
nsv1121498 CNV deletion 24896259
nsv1125576 CNV tandem duplication 24896259
nsv1129374 OTHER inversion 24896259
nsv1138253 CNV deletion 24896259
nsv1145689 CNV deletion 24896259
nsv1152339 CNV deletion 26484159
nsv456078 CNV gain 19166990
nsv456080 CNV gain 19166990
nsv471169 CNV gain 18288195
nsv517610 CNV gain+loss 19592680
nsv522179 CNV loss 19592680
nsv525194 CNV loss 19592680
nsv562767 CNV loss 21841781
nsv562768 CNV loss 21841781
nsv562769 CNV loss 21841781
nsv562770 CNV gain 21841781
nsv7246 OTHER inversion 18451855
nsv832688 CNV gain 17160897
nsv832689 CNV loss 17160897
nsv957466 CNV insertion 24416366

Variation tolerance for ABCC4 Gene

Residual Variation Intolerance Score: 33.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.48; 82.15% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ABCC4 Gene

Human Gene Mutation Database (HGMD)
ABCC4
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ABCC4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ABCC4 Gene

Disorders for ABCC4 Gene

MalaCards: The human disease database

(5) MalaCards diseases for ABCC4 Gene - From: GeneTests, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
abcc4-related altered drug metabolism
  • multidrug resistance-associated protein 4
biliary tract disease
  • biliary tract diseases
dubin-johnson syndrome
  • chronic idiopathic jaundice
cholestasis
  • bile occlusion
bile duct disease
  • bile duct disorder nos
- elite association - COSMIC cancer census association via MalaCards
Search ABCC4 in MalaCards View complete list of genes associated with diseases

Relevant External Links for ABCC4

Genetic Association Database (GAD)
ABCC4
Human Genome Epidemiology (HuGE) Navigator
ABCC4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ABCC4
genes like me logo Genes that share disorders with ABCC4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ABCC4 Gene

Publications for ABCC4 Gene

  1. Association between ABCC2 gene haplotypes and tenofovir-induced proximal tubulopathy. (PMID: 17083032) Izzedine H. … Deray A.G. (J. Infect. Dis. 2006) 3 22 46 64
  2. Multidrug resistance protein 4 (MRP4/ABCC4) mediates efflux of bimane-glutathione. (PMID: 14643890) Bai J. … Tan T.M. (Int. J. Biochem. Cell Biol. 2004) 3 22 25 64
  3. The human multidrug resistance protein MRP4 functions as a prostaglandin efflux transporter and is inhibited by nonsteroidal antiinflammatory drugs. (PMID: 12835412) Reid G. … Borst P. (Proc. Natl. Acad. Sci. U.S.A. 2003) 3 22 25 64
  4. Characterization of the transport of nucleoside analog drugs by the human multidrug resistance proteins MRP4 and MRP5. (PMID: 12695538) Reid G. … Borst P. (Mol. Pharmacol. 2003) 3 22 25 64
  5. Cotransport of reduced glutathione with bile salts by MRP4 (ABCC4) localized to the basolateral hepatocyte membrane. (PMID: 12883481) Rius M. … Keppler D. (Hepatology 2003) 3 22 25 64

Products for ABCC4 Gene

Sources for ABCC4 Gene

Content
Loading form....