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ABCC3 Gene

protein-coding   GIFtS: 69
GCID: GC17P048712

ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 3

  See ABCC3-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 31 2     ABC312
MLP22 3 5     EST907572
MRP32 3 5     cMOAT22
Canalicular Multispecific Organic Anion Transporter 21 2     Canicular Multispecific Organic Anion Transporter2
Multi-Specific Organic Anion Transporter D2 3     Multidrug Resistance Associated Protein2
Multidrug Resistance-Associated Protein 32 3     EC 3.6.38
MOAT-D2 3     EC 3.6.3.448
ATP-Binding Cassette Sub-Family C Member 32 3     EC 6.3.2.48
CMOAT23 5     

External Ids:    HGNC: 541   Entrez Gene: 87142   Ensembl: ENSG000001088467   OMIM: 6043235   UniProtKB: O154383   

Export aliases for ABCC3 gene to outside databases

Previous GC identifers: GC17P048425 GC17P051193 GC17P049054 GC17P049186 GC17P046067 GC17P044080


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ABCC3 Gene:
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC
proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven
distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily
which is involved in multi-drug resistance. The specific function of this protein has not yet been determined;
however, this protein may play a role in the transport of biliary and intestinal excretion of organic anions.
Alternatively spliced variants which encode different protein isoforms have been described; however, not all
variants have been fully characterized. (provided by RefSeq, Jul 2008)

GeneCards Summary for ABCC3 Gene:
ABCC3 (ATP-binding cassette, sub-family C (CFTR/MRP), member 3) is a protein-coding gene. Diseases associated with ABCC3 include cholangiolocellular carcinoma, and dubin-johnson syndrome. GO annotations related to this gene include ATPase activity, coupled to transmembrane movement of substances and organic anion transmembrane transporter activity. An important paralog of this gene is ABCC4.

UniProtKB/Swiss-Prot: MRP3_HUMAN, O15438
Function: May act as an inducible transporter in the biliary and intestinal excretion of organic anions. Acts as
an alternative route for the export of bile acids and glucuronides from cholestatic hepatocytes (By similarity)

Gene Wiki entry for ABCC3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NT_010783.16  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ABCC3 gene promoter:
         COUP-TF1   GR   Sp1   p53   GR-beta   COUP   HNF-4alpha2   HNF-4alpha1   COUP-TF   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidABCC3 promoter sequence
   Search Chromatin IP Primers for ABCC3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ABCC3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q22   Ensembl cytogenetic band:  17q21.33   HGNC cytogenetic band: 17q21

ABCC3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ABCC3 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P048712:  view genomic region     (about GC identifiers)

Start:
48,712,138 bp from pter      End:
48,769,613 bp from pter
Size:
57,476 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: MRP3_HUMAN, O15438 (See protein sequence)
Recommended Name: Canalicular multispecific organic anion transporter 2  
Size: 1527 amino acids; 169343 Da
Sequence caution: Sequence=AAB71756.1; Type=Frameshift; Positions=1334, 1338; Sequence=AAD01430.1;
Type=Frameshift; Positions=355, 359, 361; Sequence=AAD38185.1; Type=Erroneous translation; Note=Wrong choice of
CDS;
Secondary accessions: B2RPA9 D3DTX9 O60265 O60922 O75621 O95078 O95289 O95290 Q86X85 Q9UN52
Alternative splicing: 5 isoforms:  O15438-1   O15438-2   O15438-3   O15438-4   O15438-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ABCC3: NX_O15438

Explore proteomics data for ABCC3 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn18, Asn1006, Asn1007
  • Modification sites at PhosphoSitePlus
  • 4 DME Specific Peptides for ABCC3 (O15438)
     SVGQRQL  GEIRIDG  ASTVGEI  LSGGQRQRV 


    See ABCC3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001137542.1  NP_003777.2  

    ENSEMBL proteins: 
     ENSP00000422786   ENSP00000425697   ENSP00000395160   ENSP00000285238   ENSP00000427073  
     ENSP00000427521   ENSP00000424981   ENSP00000422058   ENSP00000421755  
    Reactome Protein details: O15438

    ABCC3 Human Recombinant Protein Products:

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    Novus Biologicals ABCC3 Lysate
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    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ABCC3

     
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    antibodies-online peptides for ABCC3

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    antibodies-online antibodies for ABCC3 (66 products) 

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    antibodies-online kits for ABCC3 (14 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ABCC: ATP binding cassette transporters / subfamily C

    IUPHAR Guide to PHARMACOLOGY protein family classification: ABCC3
    ABCC subfamily

    Selected InterPro protein domains (see all 7):
     IPR003439 ABC_transporter-like
     IPR027417 P-loop_NTPase
     IPR001140 ABC_transptr_TM_dom
     IPR003593 AAA+_ATPase
     IPR011527 ABC1_TM_dom

    Graphical View of Domain Structure for InterPro Entry O15438

    ProtoNet protein and cluster: O15438

    UniProtKB/Swiss-Prot: MRP3_HUMAN, O15438
    Similarity: Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208)
    subfamily
    Similarity: Contains 2 ABC transmembrane type-1 domains
    Similarity: Contains 2 ABC transporter domains


    Find genes that share domains with ABCC3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MRP3_HUMAN, O15438
    Function: May act as an inducible transporter in the biliary and intestinal excretion of organic anions. Acts as
    an alternative route for the export of bile acids and glucuronides from cholestatic hepatocytes (By similarity)

         Genatlas biochemistry entry for ABCC3:
    ATP binding cassette superfamily,subfamily C (CFTR/MRP),member 3,expressed in liver,colon,small intestine and
    prostate,involved in the adrenal glands,biliary and intestinal excretion of organic anions

         Enzyme Numbers (IUBMB): EC 6.3.2.42 EC 3.6.3.442 EC 3.6.32

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding ----
    GO:0005215transporter activity ----
    GO:0005524ATP binding IEA--
    GO:0008514organic anion transmembrane transporter activity TAS9738950
    GO:0016887ATPase activity ----
         
    Find genes that share ontologies with ABCC3           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for ABCC3:
     Increased circadian period len 

         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Abcc3):
     behavior/neurological  homeostasis/metabolism  integument  liver/biliary system 

    Find genes that share phenotypes with ABCC3           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for ABCC3: Abcc3tm1Kruh Abcc3tm1Bor

       genOway: Develop your customized and physiologically relevant rodent model for ABCC3

    miRNA
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    miRTarBase miRNAs that target ABCC3:
    hsa-mir-192-5p (MIRT004155), hsa-mir-124-3p (MIRT022500), hsa-mir-335-5p (MIRT017472), hsa-mir-197-3p (MIRT003824)

    Block miRNA regulation of human, mouse, rat ABCC3 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate ABCC3:
    hsa-miR-205*
    SwitchGear 3'UTR luciferase reporter plasmidABCC3 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ABCC3

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    GenScript: all cDNA clones in your preferred vector (see all 2): ABCC3 (NM_003786)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ABCC3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ABCC3

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ABCC3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MRP3_HUMAN, O15438: Membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    nucleus2
    vacuole2
    cytoskeleton1
    extracellular1
    mitochondrion1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane IEA--
    GO:0016020membrane TAS9813153
    GO:0016021integral component of membrane ----

    Find genes that share ontologies with ABCC3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ABCC3 About   (see all 13)  
    See pathways by source

    SuperPathContained pathways About
    1ABC-family proteins mediated transport
    ABC-family proteins mediated transport0.69
    ABC transporters0.69
    2Pyrimidine metabolism
    Fluoropyrimidine Activity0.69
    Fluoropyrimidine Pathway, Pharmacokinetics0.69
    3Codeine and Morphine Pathway, Pharmacokinetics
    Codeine and Morphine Pathway, Pharmacokinetics0.33
    Codeine and morphine metabolism0.00
    4Synthesis of bile acids and bile salts
    Bile acid and bile salt metabolism0.73
    Recycling of bile acids and salts0.00
    5Metabolism
    Metabolism0.38
    Metabolism of lipids and lipoproteins0.37


    Find genes that share SuperPaths with ABCC3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    4 BioSystems Pathways for ABCC3
        Fluoropyrimidine Activity
    Codeine and morphine metabolism
    Nuclear receptors in lipid metabolism and toxicity
    Drug Induction of Bile Acid Pathway

    2 Reactome Pathways for ABCC3
        ABC-family proteins mediated transport
    Recycling of bile acids and salts

    Selected PharmGKB Pathways for ABCC3 (see all 6)
        Codeine and Morphine Pathway, Pharmacokinetics
    Etoposide Pathway, Pharmacokinetics/Pharmacodynamics
    Fluoropyrimidine Pathway, Pharmacokinetics
    Lamivudine Pathway, Pharmacokinetics/Pharmacodynamics
    Methotrexate Pathway, Pharmacokinetics

    2 Kegg Pathways  (Kegg details for ABCC3):
        ABC transporters
    Bile secretion

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ABCC3: 
              Drug Transporters in human mouse rat
              Cancer Drug Resistance in human mouse rat
              Hepatotoxicity in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for ABCC3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ABCC3 (O154383 ENSP000002852384) via UniProtKB, MINT, STRING, and/or I2D (see all 29)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MLH1P406923I2D: score=1 
    ALBENSP000002958974STRING: ENSP00000295897
    FABP6ENSP000003775494STRING: ENSP00000377549
    SLC10A1ENSP000002165404STRING: ENSP00000216540
    SLC10A2ENSP000002453124STRING: ENSP00000245312
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport TAS9813153
    GO:0008206bile acid metabolic process TAS--
    GO:0015721bile acid and bile salt transport TAS--
    GO:0044281small molecule metabolic process TAS--
    GO:0055085transmembrane transport TAS--

    Find genes that share ontologies with ABCC3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ABCC3 (MRP3)

    Selected HMDB Compounds for ABCC3 (see all 85)    About this table
    CompoundSynonyms CAS #PubMed Ids
    (3a,5b,7a)-23-Carboxy-7-hydroxy-24-norcholan-3-yl-b-D-Glucopyranosiduronic acidChenodeoxycholic acid 3-glucuronide (see all 3)58814-71-4--
    1,3,12-Trihydroxycholan-24-oic acid1,3,12-Trihydroxycholan-24-oate (see all 6)63266-91-1--
    1,3,7,12-Tetrahydroxycholan-24-oic acid1,3,7,12-Tetrahydroxycholan-24-oate (see all 10)63266-89-7--
    12-Ketodeoxycholic acid12-Dehydrodeoxycholate (see all 20)5130-29-0--
    12a-Hydroxy-3-oxocholadienic acid12a-Hydroxy-3-oxo-4,6-choladien-24-oate (see all 8)13535-96-1--
    12b-Hydroxy-5b-cholanoic acid12b-Hydroxy-5b-cholanic acid (see all 9)15173-23-6--
    1b,3a,12a-Trihydroxy-5b-cholanoic acid1,3,12-trihydroxy-(5b)-Cholan-24-oate (see all 6)80434-32-8--
    1b,3a,7a-Trihydroxy-5b-cholanoic acid1 beta,3a,7a-Trihydroxy-5b-cholanoate (see all 18)99598-04-6--
    1b-Hydroxycholic acid1b,3a,7a,12a-Tetrahydroxy-5b-cholan-24-oate (see all 5)80875-94-1--
    2b,3a,7a,12a-Tetrahydroxy-5b-cholanoic acid2b,3a,7a,12a-Tetrahydroxy-5b-cholan-24-oate (see all 7)60696-60-8--

    Selected DrugBank Compounds for ABCC3 (see all 27)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    MethotrexateAmethopterin (see all 12)59-05-2transportersubstrate inhibitor11837698 11585759 10329726 12731885 12388190 19334674 10987286 12909565
    Taurocholic Acid-- 81-24-3transportersubstrate inhibitor11837698 11585759 12924948 12220224 12909565 10644759
    PhenobarbitalFenobarbital (see all 7)50-06-6transporterinducer14570762 9738950 10712264 12920174
    EtoposideEPEG (see all 4)33419-42-0transportersubstrate inhibitor11585759 19334674 11581266
    Probenecid-- 57-66-9transporterinhibitor11585759 11581266 12538836
    IndomethacinIMN (see all 9)53-86-1transporterinhibitor16460798 11581266
    LeucovorinCalcium folinate (see all 7)1492-18-8transportersubstrate11585759 12874005
    Cholic Acid-- 81-25-4transporterinhibitor10644759
    CisplatinCDDP (see all 7)15663-27-1transporterinducer11323161
    ClotrimazoleChlotrimazole (see all 2)23593-75-1transporterinducer14570758

    Selected Novoseek inferred chemical compound relationships for ABCC3 gene (see all 45)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    estradiol-17beta-glucuronide 89.7 6 10644759 (1), 14667926 (1), 12388190 (1), 12924948 (1)
    etoposide glucuronide 87.6 10 20028753 (3), 11581266 (2), 12220224 (1)
    taurocholate 71.7 8 12220224 (3), 16637898 (1), 12388190 (1), 12763363 (1) (see all 5)
    5-carboxyfluorescein 68.1 3 14603501 (1), 14570758 (1)
    androstane 68 2 14705863 (1)
    glycocholate 65.3 7 12220224 (3), 10987286 (1), 12388190 (1)
    glucuronide 62.5 3 14667926 (1), 14643890 (1)
    tbhq 60.3 1 11841785 (1)
    bile acid 59.7 4 12220224 (1), 15814571 (1)
    mk 571 59.2 1 14667926 (1)

    5 PharmGKB related drug/compound annotations for ABCC3 gene    About this table
    Drug/compound PharmGKB Annotation
    cisplatinCA  
    cyclophosphamideCA  
    doxorubicinCA  
    methotrexateCA  
    vincristineCA  



    Find genes that share compounds with ABCC3           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ABCC3 gene (4 alternative transcripts): 
    NM_001144070.1  NM_003786.3  NM_020037.1  NM_020038.1  

    Unigene Cluster for ABCC3:

    ATP-binding cassette, sub-family C (CFTR/MRP), member 3
    Hs.463421  [show with all ESTs]
    Unigene Representative Sequence: AF085692
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000515707 ENST00000513511 ENST00000427699(uc002isk.4) ENST00000285238(uc002isl.3)
    ENST00000502426 ENST00000505699 ENST00000515585 ENST00000513589 ENST00000571855(uc002ism.3)
    ENST00000515070 ENST00000503304 ENST00000510633 ENST00000506464 ENST00000513745
    ENST00000510891 ENST00000503337(uc002isn.3) ENST00000508929 ENST00000504586

    miRNA
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    1 qRT-PCR Assays for microRNA that regulate ABCC3:
    hsa-miR-205*
    SwitchGear 3'UTR luciferase reporter plasmidABCC3 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 2): ABCC3 (NM_003786)
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      QuantiFast Probe-based Assays in human, mouse, rat ABCC3

    Additional mRNA sequence: 

    AB010887.1 AB208954.1 AF009670.1 AF083552.1 AF085690.1 AF085692.1 AF104943.1 BC046126.1 
    BC050370.1 BC058907.1 BC104952.1 BC137347.1 BC137348.1 U66674.1 U83659.1 Y17151.2 

    23 DOTS entries:

    DT.215229  DT.100789082  DT.100789080  DT.92436625  DT.40118229  DT.95148897  DT.91972802  DT.92436630 
    DT.70105371  DT.444291  DT.95082800  DT.99950674  DT.121001282  DT.121001284  DT.86844736  DT.92436622 
    DT.95082810  DT.100705669  DT.40303139  DT.91940419  DT.91940550  DT.95082805  DT.95230357 

    Selected AceView cDNA sequences (see all 233):

    BU631704 BQ009190 AW195226 CA445870 BU620702 BC058907 AF154001 AF085691 
    BF515888 BC034683 AI282631 NM_003786 NM_020037 BX479469 AF085690 NM_020038 
    AF085692 AA548503 AW848421 AA937472 BC046126 AI281129 BQ084505 AA843535 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ABCC3 (see all 16)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17a · 17b ^ 18 ^ 19 ^ 20a ·
    SP1:                          -     -     -                                   -                 -                                                               
    SP2:                          -     -     -                                                     -                                                               
    SP3:                          -     -     -                                   -                 -                                                               
    SP4:                          -     -     -                                   -                 -                                                               
    SP5:                                                                                                                                                            

    ExUns: 20b ^ 21 ^ 22 ^ 23a · 23b · 23c · 23d ^ 24a · 24b · 24c ^ 25 ^ 26a · 26b · 26c ^ 27 ^ 28a · 28b ^ 29a · 29b ^ 30 ^ 31a · 31b ^ 32a · 32b ^ 33a · 33b ^
    SP1:                                      -                                                                                   -           -                 -   
    SP2:                                      -                                                                                   -           -                 -   
    SP3:                                      -                                                                                   -           -                 -   
    SP4:                                                                                                                                                            
    SP5:                                                                                                  -                                                         

    ExUns: 34 ^ 35a · 35b · 35c ^ 36 ^ 37a · 37b · 37c · 37d
    SP1:        -     -           -                           
    SP2:        -     -           -                           
    SP3:        -     -           -                           
    SP4:                                                      
    SP5:                                                      


    ECgene alternative splicing isoforms for ABCC3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ABCC3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTCAACAGTA
    ABCC3 Expression
    About this image


    ABCC3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Lung (Respiratory System)
             Alveolar type II cells
     
     Colon (Gastrointestinal Tract)
     
     Pancreas (Endocrine System)
     
     Liver (Hepatobiliary System)
     
     Adrenal Gland (Endocrine System)
    ABCC3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ABCC3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.463421

    UniProtKB/Swiss-Prot: MRP3_HUMAN, O15438
    Tissue specificity: Mainly expressed in the liver. Also expressed in small intestine, colon, prostate, testis,
    brain and at a lower level in the kidney

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ABCC3: 
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              Molecular Toxicology PathwayFinder 384HT in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ABCC3 gene from Selected species (see all 23)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Abcc31 , 5 ATP-binding cassette, sub-family C (CFTR/MRP), member more1, 5 82.45(n)1
    81.07(a)1
      11 (58.90 cM)5
    764081  NM_029600.31  NP_083876.31 
     943432985 
    chicken
    (Gallus gallus)
    Aves ABCC31 ATP-binding cassette, sub-family C (CFTR/MRP), member more 67.8(n)
    69.87(a)
      422099  XM_420102.4  XP_420102.4 
    lizard
    (Anolis carolinensis)
    Reptilia ABCC36
    ATP-binding cassette, sub-family C (CFTR/MRP), mem...
    68(a)
    1 ↔ 1
    2(117235167-117323370)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia BX732495.12   -- 71.32(n)    BX732495.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ABCC36
    ATP-binding cassette, sub-family C (CFTR/MRP), mem...
    62(a)
    1 ↔ 1
    12(892554-983336) ENSDARG00000077243
    fruit fly
    (Drosophila melanogaster)
    Insecta CG62143
    MRP1
    xenobiotic-transporting ATPase3
    Multidrug-Resistance like Protein 11
    47(a)
    (best of 2)3
    57.2(n)1
    51.44(a)1
      33F43
    346861  NM_205976.21  NP_995698.11 
    worm
    (Caenorhabditis elegans)
    Secernentea mrp-23
    mrp-71
    ATP-binding transport family3
    mrp-71
    45(a)
    (best of 4)3
    49.48(n)1
    46.13(a)1
      X(599137-607953)3
    1802891  NM_075411.41  NP_507812.31 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes YCF11 YCF1 46.78(n)
    42.48(a)
      851713   NP_010419.3 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons MRP101 MRP10 45.58(n)
    36.03(a)
      825444  NM_116135.2  NP_191829.1 
    rice
    (Oryza sativa)
    Liliopsida Os04g02092001 Os04g0209200 48.35(n)
    38.15(a)
      4335176  NM_001058786.1  NP_001052251.1 


    ENSEMBL Gene Tree for ABCC3 (if available)
    TreeFam Gene Tree for ABCC3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ABCC3 gene
    ABCC42  ABCC122  ABCC12  ABCC82  ABCC52  ABCC62  ABCC22  ABCC92  
    ABCC112  
    Selected SIMAP similar genes for ABCC3 using alignment to 9 protein entries:     MRP3_HUMAN (see all proteins) (see all similar genes):
    MRP3    DKFZp781G125    DKFZp434I2115    ABCB4    ABCC1    CTFR
    CFTR    TAP1    MRP    NG-TRA    ABCC2    ABCC6
    ABCC4    ABCC13    ABCC10    ABCC9    ABCC11    ABCC12

    Find genes that share paralogs with ABCC3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ABCC3 (see all 1521)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1994740291,2
    Cuntested148760785(+) AGTAGG/TTCTGT 1 -- int10--------
    rs1994736851,2
    Cuntested148761077(+) CCTGGT/AGCTGA 2 /E /V mis11Minor allele frequency- A:0.00EU 1323
    rs1812504971,2
    --48710356(+) CGGTGG/TGTAGA 2 -- us2k10--------
    rs1855000481,2
    C--48710360(+) GGGTAG/TACAAG 2 -- us2k10--------
    rs1898626501,2
    --48710518(+) AGAAAC/TGAAGT 2 -- us2k10--------
    rs19899831,2
    C,F,A,H--48710531(+) CAGAGG/ACATCA 2 -- us2k119Minor allele frequency- A:0.22MN NS EA NA WA 2524
    rs1807031661,2
    --48710578(+) TGGAGA/GGGGAT 2 -- us2k10--------
    rs1864867091,2
    --48710653(+) TCATAA/TCTAAA 2 -- us2k10--------
    rs1918654931,2
    --48710673(+) AGGCAC/TGCCGT 2 -- us2k10--------
    rs1442598361,2
    --48710687(+) AAGGTA/GTAAAG 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for ABCC3 (48712138 - 48769613 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for ABCC3:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2716038CNV Deletion23290073
    nsv2083CNV Insertion18451855
    dgv3230n71CNV Loss21882294
    nsv833477CNV Loss17160897
    dgv42n68CNV Loss17160897
    nsv908609CNV Gain21882294

    Human Gene Mutation Database (HGMD): ABCC3
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ABCC3
    DNA2.0 Custom Variant and Variant Library Synthesis for ABCC3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604323    OMIM disorders: --

    4 diseases for ABCC3:    
    About MalaCards
    cholangiolocellular carcinoma    dubin-johnson syndrome    extrahepatic cholestasis    obstructive jaundice

    4 diseases from the University of Copenhagen DISEASES database for ABCC3:
    Cholestasis     Lung cancer     Leukemia     Bilirubin metabolic disorder

    Find genes that share disorders with ABCC3           About GenesLikeMe

    Selected Novoseek inferred disease relationships for ABCC3 gene (see all 28)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    dubin-johnson syndrome 71.4 1 10094960 (1)
    cholestasis 68.3 10 12837754 (1), 11850532 (1), 12538803 (1), 10728790 (1) (see all 7)
    cholestasis extrahepatic 57.3 4 11076395 (1), 12428063 (1), 19185005 (1)
    breast cancer 41.7 22 12731885 (2), 18393293 (2), 10739113 (1), 14979731 (1) (see all 18)
    hepatocellular carcinoma 38 8 18250047 (3), 18619700 (2), 19956884 (1), 11745434 (1) (see all 5)
    cancer 35.8 13 9270026 (1), 10359813 (1), 12676459 (1), 10100721 (1) (see all 13)
    biliary cirrhosis primary 35 2 14568249 (1)
    glioma 32.5 11 11223551 (5), 16193381 (4)
    colon adenocarcinoma 28.4 1 17430634 (1)
    colon cancer 28 5 19593667 (3), 11820781 (1)

    Genetic Association Database (GAD): ABCC3
    Human Genome Epidemiology (HuGE) Navigator: ABCC3 (13 documents)

    Export disorders for ABCC3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ABCC3 gene, integrated from 10 sources (see all 282):
    (articles sorted by number of sources associating them with ABCC3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of MOAT-C and MOAT-D, new members of the MRP/cMOAT subfamily of transporter proteins. (PubMed id 9827529)1, 2, 3, 9 Belinsky M.G.... Kruh G.D. (J. Natl. Cancer Inst. 1998)
    2. cDNA cloning and inducible expression of human multidrug resistance associated protein 3 (MRP3). (PubMed id 9738950)1, 2, 7, 9 Kiuchi Y.... Sugiyama Y. (FEBS Lett. 1998)
    3. Transport of bile acids in multidrug-resistance-protein 3-overexpressing cells co-transfected with the ileal Na+-dependent bile-acid transporter. (PubMed id 12220224)1, 7, 9 Zelcer N....Borst P. (Biochem. J. 2003)
    4. Characterization of the human multidrug resistance protein isoform MRP3 localized to the basolateral hepatocyte membrane. (PubMed id 10094960)1, 2, 9 Koenig J.... Keppler D. (Hepatology 1999)
    5. Functional reconstitution of human ABCC3 into proteoliposomes reveals a transport mechanism with positive cooperativity. (PubMed id 19334674)1, 7, 9 Zehnpfennig B....Galla H.J. (Biochemistry 2009)
    6. Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines. (PubMed id 9270026)1, 2, 9 Kool M.... Borst P. (Cancer Res. 1997)
    7. ATP-binding cassette C transporters in human pancreatic carcinoma cell lines. Upregulation in 5-fluorouracil-resistant cells. (PubMed id 19077464)1, 7, 9 Hagmann W....LAPhr J.M. (Pancreatology 2009)
    8. Could polymorphisms in ATP-binding cassette C3/multidrug resistance associated protein 3 (ABCC3/MRP3) modify colorectal cancer risk? (PubMed id 18313914)1, 4, 9 Campa D....Canzian F. (Eur. J. Cancer 2008)
    9. Genetic variations of the ABC transporter gene ABCC3 in a Japanese population. (PubMed id 17495421)1, 4, 9 Fukushima-Uesaka H....Sawada J. (Drug Metab. Pharmacokinet. 2007)
    10. Polymorphisms in ABCG2, ABCC3 and CNT1 genes and their possible impact on chemotherapy outcome of lung cancer patients. (PubMed id 19107936)1, 4, 9 MA1ller P.J....Risch A. (Int. J. Cancer 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8714 HGNC: 54 AceView: ABCC3 Ensembl:ENSG00000108846 euGenes: HUgn8714
    ECgene: ABCC3 Kegg: 8714 H-InvDB: ABCC3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ABCC3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ABCC3 Genetics and Cytogenetics in Oncology and Haematology
    ABCMdbhttp://abcmutations.hegelab.org/proteinDetails?uniprot_id=O15438

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ABCC3 gene:
    Search GeneIP for patents involving ABCC3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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