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Aliases for ABCC3 Gene

Aliases for ABCC3 Gene

  • ATP Binding Cassette Subfamily C Member 3 2 3 5
  • ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 3 2 3
  • Multi-Specific Organic Anion Transporter D 3 4
  • ATP-Binding Cassette Sub-Family C Member 3 3 4
  • Multidrug Resistance-Associated Protein 3 3 4
  • CMOAT2 3 4
  • MOAT-D 3 4
  • MLP2 3 4
  • MRP3 3 4
  • Canalicular Multispecific Organic Anion Transporter 2 2
  • Canicular Multispecific Organic Anion Transporter 3
  • Multidrug Resistance Associated Protein 3
  • EC 3.6.3.44 63
  • EC 6.3.2.4 63
  • EST90757 3
  • EC 3.6.3 63
  • ABC31 3

External Ids for ABCC3 Gene

Previous GeneCards Identifiers for ABCC3 Gene

  • GC17P048425
  • GC17P051193
  • GC17P049054
  • GC17P049186
  • GC17P046067
  • GC17P048712
  • GC17P044080

Summaries for ABCC3 Gene

Entrez Gene Summary for ABCC3 Gene

  • The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The specific function of this protein has not yet been determined; however, this protein may play a role in the transport of biliary and intestinal excretion of organic anions. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]

GeneCards Summary for ABCC3 Gene

ABCC3 (ATP Binding Cassette Subfamily C Member 3) is a Protein Coding gene. Diseases associated with ABCC3 include extrahepatic cholestasis and dubin-johnson syndrome. Among its related pathways are ABC-family proteins mediated transport and Bile secretion. GO annotations related to this gene include transporter activity and ATPase activity, coupled to transmembrane movement of substances. An important paralog of this gene is ABCC1.

UniProtKB/Swiss-Prot for ABCC3 Gene

  • May act as an inducible transporter in the biliary and intestinal excretion of organic anions. Acts as an alternative route for the export of bile acids and glucuronides from cholestatic hepatocytes (By similarity).

Gene Wiki entry for ABCC3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ABCC3 Gene

Genomics for ABCC3 Gene

Regulatory Elements for ABCC3 Gene

Enhancers for ABCC3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ABCC3 on UCSC Golden Path with GeneCards custom track

Promoters for ABCC3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ABCC3 on UCSC Golden Path with GeneCards custom track

Genomic Location for ABCC3 Gene

Chromosome:
17
Start:
50,634,777 bp from pter
End:
50,692,252 bp from pter
Size:
57,476 bases
Orientation:
Plus strand

Genomic View for ABCC3 Gene

Genes around ABCC3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ABCC3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ABCC3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ABCC3 Gene

Proteins for ABCC3 Gene

  • Protein details for ABCC3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15438-MRP3_HUMAN
    Recommended name:
    Canalicular multispecific organic anion transporter 2
    Protein Accession:
    O15438
    Secondary Accessions:
    • B2RPA9
    • D3DTX9
    • O60265
    • O60922
    • O75621
    • O95078
    • O95289
    • O95290
    • Q86X85
    • Q9UN52

    Protein attributes for ABCC3 Gene

    Size:
    1527 amino acids
    Molecular mass:
    169343 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAB71756.1; Type=Frameshift; Positions=1334, 1338; Evidence={ECO:0000305}; Sequence=AAD01430.1; Type=Frameshift; Positions=355, 359, 361; Evidence={ECO:0000305}; Sequence=AAD38185.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};

    Alternative splice isoforms for ABCC3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ABCC3 Gene

Proteomics data for ABCC3 Gene at MOPED

Selected DME Specific Peptides for ABCC3 Gene

Post-translational modifications for ABCC3 Gene

  • Glycosylation at Asn 18, Asn 1006, and Asn 1007
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for ABCC3 (ABCC3)

Domains & Families for ABCC3 Gene

Gene Families for ABCC3 Gene

Graphical View of Domain Structure for InterPro Entry

O15438

UniProtKB/Swiss-Prot:

MRP3_HUMAN :
  • Contains 2 ABC transmembrane type-1 domains.
  • Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
Domain:
  • Contains 2 ABC transmembrane type-1 domains.
  • Contains 2 ABC transporter domains.
Family:
  • Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
genes like me logo Genes that share domains with ABCC3: view

Function for ABCC3 Gene

Molecular function for ABCC3 Gene

GENATLAS Biochemistry:
ATP binding cassette superfamily,subfamily C (CFTR/MRP),member 3,expressed in liver,colon,small intestine and prostate,involved in the adrenal glands,biliary and intestinal excretion of organic anions
UniProtKB/Swiss-Prot Function:
May act as an inducible transporter in the biliary and intestinal excretion of organic anions. Acts as an alternative route for the export of bile acids and glucuronides from cholestatic hepatocytes (By similarity).

Enzyme Numbers (IUBMB) for ABCC3 Gene

Gene Ontology (GO) - Molecular Function for ABCC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016887 ATPase activity IEA --
GO:0042626 ATPase activity, coupled to transmembrane movement of substances IEA,TAS 9813153
genes like me logo Genes that share ontologies with ABCC3: view
genes like me logo Genes that share phenotypes with ABCC3: view

Animal Models for ABCC3 Gene

MGI Knock Outs for ABCC3:

Animal Model Products

  • Taconic Biosciences Mouse Models for ABCC3

CRISPR Products

miRNA for ABCC3 Gene

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ABCC3 Gene

Localization for ABCC3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ABCC3 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ABCC3 Gene COMPARTMENTS Subcellular localization image for ABCC3 gene
Compartment Confidence
plasma membrane 5
nucleus 2
cytoskeleton 1
cytosol 1
extracellular 1
mitochondrion 1
vacuole 1

Gene Ontology (GO) - Cellular Components for ABCC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane TAS 9813153
genes like me logo Genes that share ontologies with ABCC3: view

Pathways & Interactions for ABCC3 Gene

genes like me logo Genes that share pathways with ABCC3: view

Interacting Proteins for ABCC3 Gene

Gene Ontology (GO) - Biological Process for ABCC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA,TAS 9813153
GO:0008152 metabolic process IEA --
GO:0015721 bile acid and bile salt transport TAS --
genes like me logo Genes that share ontologies with ABCC3: view

No data available for SIGNOR curated interactions for ABCC3 Gene

Drugs & Compounds for ABCC3 Gene

(51) Drugs for ABCC3 Gene - From: DrugBank, PharmGKB, FDA Approved Drugs, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cisplatin Approved Pharma Transporter, inducer Inhibits DNA synthesis,chemotherapy drug, Platinum 2569
Doxorubicin Approved, Investigational Pharma Transporter, inhibitor Topo II inhibitor,immunosuppresive antineoplastic antibiotic 1649
Methotrexate Approved Pharma Transporter, substrate, inhibitor Folate antagonist,inhibits DFHR, Cytotoxic agent 1466
Vincristine Approved, Investigational Pharma Transporter, inhibitor Microtubule disrupter,antitumor agent 870
Etoposide Approved Pharma Transporter, substrate, inhibitor Topo II inhibitor, Topoisomerase 2 Inhibitors, Topoisomerase II inhibitor 1189

(101) Additional Compounds for ABCC3 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(3a,5b,7a)-23-Carboxy-7-hydroxy-24-norcholan-3-yl-b-D-Glucopyranosiduronic acid
  • Chenodeoxycholic acid 3-glucuronide
  • Chenodeoxycholic acid-3-b-D-glucuronide
  • Chenodeoxycholic acid-3-beta-delta-glucuronide
58814-71-4
1,3,12-Trihydroxycholan-24-oic acid
  • 1,3,12-Trihydroxy-5b-Cholanoate
  • 1,3,12-Trihydroxy-5b-Cholanoic acid
  • 1,3,12-Trihydroxy-Cholan-24-oate
  • 1,3,12-Trihydroxy-Cholan-24-oic acid
  • 1,3,12-Trihydroxycholan-24-oate
63266-91-1
1,3,7,12-Tetrahydroxycholan-24-oic acid
  • 1,3,7,12-Tetrahydroxy-Cholan-24-oate
  • 1,3,7,12-Tetrahydroxy-Cholan-24-oic acid
  • 1,3,7,12-Tetrahydroxycholan-24-oate
  • 1,3,7,12-Tetrahydroxycholan-24-oic acid
  • 1,3,7,12-Tetrahydroxycholanoate
63266-89-7
12a-Hydroxy-3-oxocholadienic acid
  • 12a-Hydroxy-3-oxo-4,6-choladien-24-oate
  • 12a-Hydroxy-3-oxo-4,6-choladien-24-oic acid
  • 12a-Hydroxy-3-oxo-Chola-4,6-dienate
  • 12a-Hydroxy-3-oxo-Chola-4,6-dienic acid
  • 12a-Hydroxy-3-oxochola-4,6-dienate
13535-96-1
12b-Hydroxy-5b-cholanoic acid
  • 12-Hydroxy-(5b,12b)-Cholan-24-oate
  • 12-Hydroxy-(5b,12b)-Cholan-24-oic acid
  • 12b-Hydroxy-5b-Cholan-24-oate
  • 12b-Hydroxy-5b-Cholan-24-oic acid
  • 12b-Hydroxy-5b-cholanic acid
15173-23-6
genes like me logo Genes that share compounds with ABCC3: view

Transcripts for ABCC3 Gene

Unigene Clusters for ABCC3 Gene

ATP-binding cassette, sub-family C (CFTR/MRP), member 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ABCC3 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17a · 17b ^ 18 ^ 19 ^ 20a ·
SP1: - - - - -
SP2: - - - -
SP3: - - - - -
SP4: - - - - -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10: -
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:

ExUns: 20b ^ 21 ^ 22 ^ 23a · 23b · 23c · 23d ^ 24a · 24b · 24c ^ 25 ^ 26a · 26b · 26c ^ 27 ^ 28a · 28b ^ 29a · 29b ^ 30 ^ 31a · 31b ^ 32a · 32b ^ 33a · 33b ^
SP1: - - - -
SP2: - - - -
SP3: - - - -
SP4:
SP5: -
SP6: - -
SP7:
SP8:
SP9: -
SP10:
SP11:
SP12: - -
SP13:
SP14:
SP15:
SP16:

ExUns: 34 ^ 35a · 35b · 35c ^ 36 ^ 37a · 37b · 37c · 37d
SP1: - - -
SP2: - - -
SP3: - - -
SP4:
SP5:
SP6: - - -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15: -
SP16:

Relevant External Links for ABCC3 Gene

GeneLoc Exon Structure for
ABCC3
ECgene alternative splicing isoforms for
ABCC3

Expression for ABCC3 Gene

mRNA expression in normal human tissues for ABCC3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ABCC3 Gene

This gene is overexpressed in Adrenal Gland (x9.2), Liver (x7.7), Colon - Transverse (x5.6), and Pancreas (x4.2).

Protein differential expression in normal tissues from HIPED for ABCC3 Gene

This gene is overexpressed in Islet of Langerhans (27.8), Pancreas (10.9), and Adrenal (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ABCC3 Gene



SOURCE GeneReport for Unigene cluster for ABCC3 Gene Hs.463421

mRNA Expression by UniProt/SwissProt for ABCC3 Gene

O15438-MRP3_HUMAN
Tissue specificity: Mainly expressed in the liver. Also expressed in small intestine, colon, prostate, testis, brain and at a lower level in the kidney.
genes like me logo Genes that share expression patterns with ABCC3: view

Primer Products

In Situ Assay Products

No data available for Protein tissue co-expression partners for ABCC3 Gene

Orthologs for ABCC3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ABCC3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ABCC3 35
  • 85.92 (n)
  • 84.94 (a)
ABCC3 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ABCC3 35
  • 86.33 (n)
  • 84.82 (a)
ABCC3 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Abcc3 35
  • 82.45 (n)
  • 81.07 (a)
Abcc3 16
Abcc3 36
  • 81 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ABCC3 35
  • 94.78 (n)
  • 93.89 (a)
ABCC3 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Abcc3 35
  • 81.65 (n)
  • 79.63 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 77 (a)
OneToMany
-- 36
  • 70 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia ABCC3 36
  • 61 (a)
OneToOne
chicken
(Gallus gallus)
Aves ABCC3 35
  • 67.8 (n)
  • 69.87 (a)
ABCC3 36
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ABCC3 36
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia abcc3 35
  • 64.87 (n)
  • 67.76 (a)
zebrafish
(Danio rerio)
Actinopterygii ABCC3 36
  • 62 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG6214 37
  • 47 (a)
Sur 37
  • 45 (a)
MRP 35
  • 57.2 (n)
  • 51.44 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009835 35
  • 53.5 (n)
  • 46.44 (a)
worm
(Caenorhabditis elegans)
Secernentea C18C4.2 37
  • 23 (a)
mrp-2 37
  • 45 (a)
mrp-7 37
  • 38 (a)
mrp-8 37
  • 42 (a)
mrp-7 35
  • 49.48 (n)
  • 46.13 (a)
cft-1 36
  • 24 (a)
ManyToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR047W 35
  • 48.26 (n)
  • 42.68 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F20075g 35
  • 47.8 (n)
  • 44.03 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YCF1 35
  • 46.78 (n)
  • 42.48 (a)
YCF1 36
  • 39 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons MRP10 35
  • 45.58 (n)
  • 36.03 (a)
rice
(Oryza sativa)
Liliopsida Os04g0209200 35
  • 48.35 (n)
  • 38.15 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU09012 35
  • 51.85 (n)
  • 42.49 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes abc2 35
  • 46.4 (n)
  • 42.36 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 34 (a)
OneToMany
Species with no ortholog for ABCC3:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ABCC3 Gene

ENSEMBL:
Gene Tree for ABCC3 (if available)
TreeFam:
Gene Tree for ABCC3 (if available)

Paralogs for ABCC3 Gene

Paralogs for ABCC3 Gene

genes like me logo Genes that share paralogs with ABCC3: view

Variants for ABCC3 Gene

Sequence variations from dbSNP and Humsavar for ABCC3 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs11568605 - 50,663,719(+) CCCCT(C/G/T)CTGGT nc-transcript-variant, reference, synonymous-codon, missense
rs11568591 - 50,683,692(+) TGTGC(A/G)CTACC nc-transcript-variant, reference, missense
rs11568590 - 50,684,088(+) CTCTC(A/G)GCTGA nc-transcript-variant, reference, missense
rs45461799 - 50,684,736(+) CCCTG(A/C/G/T)GCATG nc-transcript-variant, reference, missense
rs11568609 - 50,634,968(+) GCTCG(A/G)CTCCA nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for ABCC3 Gene

Variant ID Type Subtype PubMed ID
nsv833477 CNV Loss 17160897
dgv3230n71 CNV Loss 21882294
dgv42n68 CNV Loss 17160897
nsv2083 CNV Insertion 18451855
nsv908609 CNV Gain 21882294
esv2716038 CNV Deletion 23290073

Variation tolerance for ABCC3 Gene

Residual Variation Intolerance Score: 42.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.81; 73.76% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ABCC3 Gene

HapMap Linkage Disequilibrium report
ABCC3
Human Gene Mutation Database (HGMD)
ABCC3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ABCC3 Gene

Disorders for ABCC3 Gene

MalaCards: The human disease database

(11) MalaCards diseases for ABCC3 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
extrahepatic cholestasis
  • extrahepatic biliary stasis
dubin-johnson syndrome
  • chronic idiopathic jaundice
cholangiolocellular carcinoma
cholestasis
  • bile occlusion
lung papillary adenocarcinoma
  • papillary adenocarcinoma of the lung
- elite association - COSMIC cancer census association via MalaCards
Search ABCC3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for ABCC3

Genetic Association Database (GAD)
ABCC3
Human Genome Epidemiology (HuGE) Navigator
ABCC3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ABCC3
genes like me logo Genes that share disorders with ABCC3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ABCC3 Gene

Publications for ABCC3 Gene

  1. Characterization of MOAT-C and MOAT-D, new members of the MRP/cMOAT subfamily of transporter proteins. (PMID: 9827529) Belinsky M.G. … Kruh G.D. (J. Natl. Cancer Inst. 1998) 2 3 4 23 67
  2. Functional reconstitution of human ABCC3 into proteoliposomes reveals a transport mechanism with positive cooperativity. (PMID: 19334674) Zehnpfennig B. … Galla H.J. (Biochemistry 2009) 3 23 25 26
  3. Transport of glyburide by placental ABC transporters: implications in fetal drug exposure. (PMID: 16460798) Gedeon C. … Piquette-Miller M. (Placenta 2006) 3 23 25 26
  4. Transport of bile acids in multidrug-resistance-protein 3-overexpressing cells co-transfected with the ileal Na+-dependent bile-acid transporter. (PMID: 12220224) Zelcer N. … Borst P. (Biochem. J. 2003) 3 23 25 26
  5. ATP-binding cassette C transporters in human pancreatic carcinoma cell lines. Upregulation in 5-fluorouracil-resistant cells. (PMID: 19077464) Hagmann W. … LAPhr J.M. (Pancreatology 2009) 3 23 25

Products for ABCC3 Gene

Sources for ABCC3 Gene

Content