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ABCC3 Gene(Protein Coding)

ATP Binding Cassette Subfamily C Member 3

GCID:
GC17P050634
GIFtS:
66
Genes Participants
UDN Logo

Aliases for ABCC3 Gene

Aliases for ABCC3 Gene

  • ATP Binding Cassette Subfamily C Member 3 2 3 5
  • ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 3 2 3
  • Canalicular Multispecific Organic Anion Transporter 2 2 3
  • Multi-Specific Organic Anion Transporter D 3 4
  • ATP-Binding Cassette Sub-Family C Member 3 3 4
  • Multidrug Resistance-Associated Protein 3 3 4
  • CMOAT2 3 4
  • MOAT-D 3 4
  • MLP2 3 4
  • MRP3 3 4
  • Canicular Multispecific Organic Anion Transporter 3
  • Multidrug Resistance Associated Protein 3
  • EC 3.6.3.44 61
  • EC 6.3.2.4 61
  • EST90757 3
  • EC 3.6.3 61
  • ABC31 3

External Ids for ABCC3 Gene

Previous GeneCards Identifiers for ABCC3 Gene

  • GC17P048425
  • GC17P051193
  • GC17P049054
  • GC17P049186
  • GC17P046067
  • GC17P048712
  • GC17P044080

Summaries for ABCC3 Gene

Entrez Gene Summary for ABCC3 Gene

  • The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The specific function of this protein has not yet been determined; however, this protein may play a role in the transport of biliary and intestinal excretion of organic anions. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]

CIViC summary for ABCC3 Gene

GeneCards Summary for ABCC3 Gene

ABCC3 (ATP Binding Cassette Subfamily C Member 3) is a Protein Coding gene. Diseases associated with ABCC3 include Dubin-Johnson Syndrome and Extrahepatic Cholestasis. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Methotrexate Pathway, Pharmacokinetics. GO annotations related to this gene include transporter activity and ATPase activity, coupled to transmembrane movement of substances. An important paralog of this gene is ABCC1.

UniProtKB/Swiss-Prot for ABCC3 Gene

  • May act as an inducible transporter in the biliary and intestinal excretion of organic anions. Acts as an alternative route for the export of bile acids and glucuronides from cholestatic hepatocytes (By similarity).

Gene Wiki entry for ABCC3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ABCC3 Gene

Genomics for ABCC3 Gene

Products:

  1. Regulatory Element

Regulatory Elements for ABCC3 Gene

Enhancers for ABCC3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G050683 1.6 Ensembl ENCODE dbSUPER 25.3 +55.8 55766 13.9 FOXA2 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 ABCC3 ANKRD40 EPN3 LUC7L3 LOC101927253 SPATA20 LOC105371824 CACNA1G-AS1 ENSG00000250976 CACNA1G
GH17G050633 1.7 FANTOM5 ENCODE dbSUPER 19.8 +4.2 4175 10.1 PKNOX1 FOXA2 MLX CREB3L1 AGO1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ABCC3 CHAD MYCBPAP ENSG00000249451 CACNA1G CACNA1G-AS1 SPATA20 LOC105371824 EPN3 ANKRD40
GH17G050659 1.6 Ensembl ENCODE dbSUPER 18 +27.2 27203 4.9 HDGF PKNOX1 FOXA2 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZBTB7B ABCC3 ANKRD40 LOC101927253 CACNA1G-AS1 CACNA1G EPN3 SPATA20 LOC105371824 ACSF2 MYCBPAP
GH17G050681 1.5 Ensembl ENCODE dbSUPER 12.1 +46.9 46878 1.1 HDGF PKNOX1 ZNF493 ZFP64 ARID4B SIN3A ZBTB7B ZNF207 ZNF143 ZNF263 ENSG00000262837 MYCBPAP LOC101927253 ABCC3 ANKRD40 SPATA20 LOC105371824 EPN3 COL1A1 KAT7
GH17G050667 1.4 Ensembl ENCODE dbSUPER 11.9 +33.7 33656 2.1 DNMT3B THRB RARA SCRT2 EGR2 ELF1 NR2F2 SSRP1 ZNF341 ETV4 SPATA20 ABCC3 LOC101927253 CACNA1G CACNA1G-AS1 LOC105371824 EPN3 MYCBPAP WFIKKN2 CHAD
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ABCC3 on UCSC Golden Path with GeneCards custom track

Promoters for ABCC3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000095703 223 801 ELF3 TBP ARID4B SIN3A ZNF48 RAD21 ZBTB7B RCOR1 FOS PCBP1

Transcription factor binding sites by QIAGEN in the ABCC3 gene promoter:

Genomic Location for ABCC3 Gene

Chromosome:
17
Start:
50,634,777 bp from pter
End:
50,692,252 bp from pter
Size:
57,476 bases
Orientation:
Plus strand

Genomic View for ABCC3 Gene

Genes around ABCC3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ABCC3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ABCC3 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for ABCC3 Gene

Proteins for ABCC3 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for ABCC3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15438-MRP3_HUMAN
    Recommended name:
    Canalicular multispecific organic anion transporter 2
    Protein Accession:
    O15438
    Secondary Accessions:
    • B2RPA9
    • D3DTX9
    • O60265
    • O60922
    • O75621
    • O95078
    • O95289
    • O95290
    • Q86X85
    • Q9UN52

    Protein attributes for ABCC3 Gene

    Size:
    1527 amino acids
    Molecular mass:
    169343 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAB71756.1; Type=Frameshift; Positions=1334, 1338; Evidence={ECO:0000305}; Sequence=AAD01430.1; Type=Frameshift; Positions=355, 359, 361; Evidence={ECO:0000305}; Sequence=AAD38185.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};

    Alternative splice isoforms for ABCC3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ABCC3 Gene

Protein Expression for ABCC3 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for ABCC3 Gene

O15438:
  • SVGQRQL
  • GEIRIDG
  • LSGGQRQRV
  • ASTVGEI

Post-translational modifications for ABCC3 Gene

  • Glycosylation at Asn18, posLast=10061006, and posLast=10071007
  • Modification sites at PhosphoSitePlus

Other Protein References for ABCC3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for ABCC3 (ABCC3)
  • Cloud-Clone Corp. Antibodies for ABCC3

Domains & Families for ABCC3 Gene

Gene Families for ABCC3 Gene

HGNC:
IUPHAR :

Protein Domains for ABCC3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ABCC3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O15438

UniProtKB/Swiss-Prot:

MRP3_HUMAN :
  • Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
Family:
  • Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
genes like me logo Genes that share domains with ABCC3: view

Function for ABCC3 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for ABCC3 Gene

GENATLAS Biochemistry:
ATP binding cassette superfamily,subfamily C (CFTR/MRP),member 3,expressed in liver,colon,small intestine and prostate,involved in the adrenal glands,biliary and intestinal excretion of organic anions
UniProtKB/Swiss-Prot Function:
May act as an inducible transporter in the biliary and intestinal excretion of organic anions. Acts as an alternative route for the export of bile acids and glucuronides from cholestatic hepatocytes (By similarity).

Enzyme Numbers (IUBMB) for ABCC3 Gene

Gene Ontology (GO) - Molecular Function for ABCC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity IEA --
GO:0005524 ATP binding IEA --
GO:0008514 organic anion transmembrane transporter activity TAS 9738950
GO:0008559 xenobiotic-transporting ATPase activity IBA --
GO:0015432 bile acid-exporting ATPase activity TAS --
genes like me logo Genes that share ontologies with ABCC3: view
genes like me logo Genes that share phenotypes with ABCC3: view

Animal Models for ABCC3 Gene

MGI Knock Outs for ABCC3:

Animal Model Products

  • Taconic Biosciences Mouse Models for ABCC3

CRISPR Products

miRNA for ABCC3 Gene

miRTarBase miRNAs that target ABCC3

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ABCC3 Gene

Localization for ABCC3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ABCC3 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ABCC3 gene
Compartment Confidence
plasma membrane 5
nucleus 2
cytoskeleton 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for ABCC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA,IEA --
GO:0016020 membrane IEA,TAS 9813153
GO:0016021 integral component of membrane IEA --
GO:0016323 basolateral plasma membrane IBA --
genes like me logo Genes that share ontologies with ABCC3: view

Pathways & Interactions for ABCC3 Gene

genes like me logo Genes that share pathways with ABCC3: view

Gene Ontology (GO) - Biological Process for ABCC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport TAS,IEA 9813153
GO:0006855 drug transmembrane transport IBA --
GO:0015721 bile acid and bile salt transport TAS --
GO:0042908 xenobiotic transport IBA --
GO:0055085 transmembrane transport TAS,IEA --
genes like me logo Genes that share ontologies with ABCC3: view

No data available for SIGNOR curated interactions for ABCC3 Gene

Drugs & Compounds for ABCC3 Gene

Products:

  1. Drug

(51) Drugs for ABCC3 Gene - From: DrugBank, PharmGKB, FDA Approved Drugs, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cisplatin Approved Pharma Transporter, inducer Inhibits DNA synthesis,chemotherapy drug, Platinum, Potent pro-apoptotic anticancer agent; activates caspase-3 2770
Doxorubicin Approved, Investigational Pharma Transporter, inhibitor Topo II inhibitor,immunosuppresive antineoplastic antibiotic 1751
Methotrexate Approved Pharma Transporter, substrate, inhibitor Folate antagonist,inhibits DFHR 1551
Vincristine Approved, Investigational Pharma Transporter, inhibitor Microtubule disrupter,antitumor agent 922
Etoposide Approved Pharma Transporter, substrate, inhibitor Topo II inhibitor, Topoisomerase 2 Inhibitors, Topoisomerase II inhibitor 1269

(100) Additional Compounds for ABCC3 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(3a,5b,7a)-23-Carboxy-7-hydroxy-24-norcholan-3-yl-b-D-Glucopyranosiduronic acid
  • Chenodeoxycholic acid 3-glucuronide
  • Chenodeoxycholic acid-3-b-D-glucuronide
  • Chenodeoxycholic acid-3-beta-delta-glucuronide
 58814-71-4
1,3,12-Trihydroxycholan-24-oic acid
  • 1,3,12-Trihydroxy-5b-Cholanoate
  • 1,3,12-Trihydroxy-5b-Cholanoic acid
  • 1,3,12-Trihydroxy-Cholan-24-oate
  • 1,3,12-Trihydroxy-Cholan-24-oic acid
  • 1,3,12-Trihydroxycholan-24-oate
 63266-91-1
1,3,7,12-Tetrahydroxycholan-24-oic acid
  • 1,3,7,12-Tetrahydroxy-Cholan-24-oate
  • 1,3,7,12-Tetrahydroxy-Cholan-24-oic acid
  • 1,3,7,12-Tetrahydroxycholan-24-oate
  • 1,3,7,12-Tetrahydroxycholan-24-oic acid
  • 1,3,7,12-Tetrahydroxycholanoate
 63266-89-7
12a-Hydroxy-3-oxocholadienic acid
  • 12a-Hydroxy-3-oxo-4,6-choladien-24-oate
  • 12a-Hydroxy-3-oxo-4,6-choladien-24-oic acid
  • 12a-Hydroxy-3-oxo-Chola-4,6-dienate
  • 12a-Hydroxy-3-oxo-Chola-4,6-dienic acid
  • 12a-Hydroxy-3-oxochola-4,6-dienate
 13535-96-1
12b-Hydroxy-5b-cholanoic acid
  • 12-Hydroxy-(5b,12b)-Cholan-24-oate
  • 12-Hydroxy-(5b,12b)-Cholan-24-oic acid
  • 12b-Hydroxy-5b-Cholan-24-oate
  • 12b-Hydroxy-5b-Cholan-24-oic acid
  • 12b-Hydroxy-5b-cholanic acid
 15173-23-6
genes like me logo Genes that share compounds with ABCC3: view

Transcripts for ABCC3 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for ABCC3 Gene

(11) REFSEQ mRNAs :
(16) Additional mRNA sequences :
(233) Selected AceView cDNA sequences:
(18) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ABCC3 Gene

ATP-binding cassette, sub-family C (CFTR/MRP), member 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ABCC3 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17a · 17b ^ 18 ^ 19 ^ 20a ·
SP1: - - - - -
SP2: - - - -
SP3: - - - - -
SP4: - - - - -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10: -
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:

ExUns: 20b ^ 21 ^ 22 ^ 23a · 23b · 23c · 23d ^ 24a · 24b · 24c ^ 25 ^ 26a · 26b · 26c ^ 27 ^ 28a · 28b ^ 29a · 29b ^ 30 ^ 31a · 31b ^ 32a · 32b ^ 33a · 33b ^
SP1: - - - -
SP2: - - - -
SP3: - - - -
SP4:
SP5: -
SP6: - -
SP7:
SP8:
SP9: -
SP10:
SP11:
SP12: - -
SP13:
SP14:
SP15:
SP16:

ExUns: 34 ^ 35a · 35b · 35c ^ 36 ^ 37a · 37b · 37c · 37d
SP1: - - -
SP2: - - -
SP3: - - -
SP4:
SP5:
SP6: - - -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15: -
SP16:

Relevant External Links for ABCC3 Gene

GeneLoc Exon Structure for
ABCC3
ECgene alternative splicing isoforms for
ABCC3

Expression for ABCC3 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ABCC3 Gene

mRNA expression in normal human tissues for ABCC3 Gene
mRNA expression by BioGPS for ABCC3 GenemRNA expression by GTEx for ABCC3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ABCC3 Gene

This gene is overexpressed in Adrenal Gland (x9.2), Liver (x7.7), Colon - Transverse (x5.6), and Pancreas (x4.2).

Protein differential expression in normal tissues from HIPED for ABCC3 Gene

This gene is overexpressed in Islet of Langerhans (27.8), Pancreas (10.9), and Adrenal (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ABCC3 Gene



NURSA nuclear receptor signaling pathways regulating expression of ABCC3 Gene:

ABCC3

SOURCE GeneReport for Unigene cluster for ABCC3 Gene:

Hs.463421

mRNA Expression by UniProt/SwissProt for ABCC3 Gene:

O15438-MRP3_HUMAN
Tissue specificity: Mainly expressed in the liver. Also expressed in small intestine, colon, prostate, testis, brain and at a lower level in the kidney.

Evidence on tissue expression from TISSUES for ABCC3 Gene

  • Liver(4.7)
  • Blood(4.5)
  • Intestine(3.5)
  • Kidney(2.3)
  • Gall bladder(2.1)
  • Lung(2)
genes like me logo Genes that share expression patterns with ABCC3: view

Primer Products

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ABCC3 Gene

Orthologs for ABCC3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ABCC3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia ABCC3 34 35
  • 94.78 (n)
dog
(Canis familiaris)
 Mammalia ABCC3 34 35
  • 86.33 (n)
cow
(Bos Taurus)
 Mammalia ABCC3 34 35
  • 85.92 (n)
mouse
(Mus musculus)
 Mammalia Abcc3 34 16 35
  • 82.45 (n)
rat
(Rattus norvegicus)
 Mammalia Abcc3 34
  • 81.65 (n)
oppossum
(Monodelphis domestica)
 Mammalia -- 35
  • 77 (a)
 OneToMany
-- 35
  • 70 (a)
 OneToMany
platypus
(Ornithorhynchus anatinus)
 Mammalia ABCC3 35
  • 61 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves ABCC3 34 35
  • 67.8 (n)
lizard
(Anolis carolinensis)
 Reptilia ABCC3 35
  • 68 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia abcc3 34
  • 64.87 (n)
zebrafish
(Danio rerio)
 Actinopterygii ABCC3 35
  • 62 (a)
 OneToOne
fruit fly
(Drosophila melanogaster)
 Insecta MRP 34
  • 57.2 (n)
CG6214 36
  • 47 (a)
Sur 36
  • 45 (a)
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP009835 34
  • 53.5 (n)
worm
(Caenorhabditis elegans)
 Secernentea mrp-7 36 34
  • 49.48 (n)
mrp-2 36
  • 45 (a)
mrp-8 36
  • 42 (a)
cft-1 35
  • 24 (a)
 ManyToMany
C18C4.2 36
  • 23 (a)
A. gosspyii yeast
(Ashbya gossypii)
 Saccharomycetes AGOS_AGR047W 34
  • 48.26 (n)
K. lactis yeast
(Kluyveromyces lactis)
 Saccharomycetes KLLA0F20075g 34
  • 47.8 (n)
baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes YCF1 34 35
  • 46.78 (n)
thale cress
(Arabidopsis thaliana)
 eudicotyledons MRP10 34
  • 45.58 (n)
rice
(Oryza sativa)
 Liliopsida Os04g0209200 34
  • 48.35 (n)
bread mold
(Neurospora crassa)
 Ascomycetes NCU09012 34
  • 51.85 (n)
fission yeast
(Schizosaccharomyces pombe)
 Schizosaccharomycetes abc2 34
  • 46.4 (n)
sea squirt
(Ciona savignyi)
 Ascidiacea -- 35
  • 34 (a)
 OneToMany
Species where no ortholog for ABCC3 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ABCC3 Gene

ENSEMBL:
Gene Tree for ABCC3 (if available)
TreeFam:
Gene Tree for ABCC3 (if available)

Paralogs for ABCC3 Gene

Variants for ABCC3 Gene

Sequence variations from dbSNP and Humsavar for ABCC3 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000017617 -- 50,669,867(+) CATGG(A/G)ACGCT intron-variant
rs1000035374 -- 50,634,916(+) CTTCC(C/T)TGCAG nc-transcript-variant, utr-variant-5-prime
rs1000088582 -- 50,661,968(+) GACTC(A/G)GGTGT intron-variant
rs1000164889 -- 50,653,358(+) AAAAA(A/G)AAAAA intron-variant
rs1000192556 -- 50,643,864(+) GAGGA(C/T)CAGGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ABCC3 Gene

Variant ID Type Subtype PubMed ID
dgv42n68 CNV loss 17160897
esv2716038 CNV deletion 23290073
nsv2083 CNV insertion 18451855
nsv833477 CNV loss 17160897

Variation tolerance for ABCC3 Gene

Residual Variation Intolerance Score: 42.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.81; 73.76% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ABCC3 Gene

Human Gene Mutation Database (HGMD)
ABCC3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ABCC3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ABCC3 Gene

Disorders for ABCC3 Gene

MalaCards: The human disease database

(8) MalaCards diseases for ABCC3 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
dubin-johnson syndrome
  • chronic idiopathic jaundice
extrahepatic cholestasis
  • extrahepatic biliary stasis
cholangiolocellular carcinoma
cholestasis
  • bile occlusion
bile duct carcinoma
  • bile duct cancer
- elite association - COSMIC cancer census association via MalaCards
Search ABCC3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for ABCC3

Genetic Association Database (GAD)
ABCC3
Human Genome Epidemiology (HuGE) Navigator
ABCC3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ABCC3
genes like me logo Genes that share disorders with ABCC3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ABCC3 Gene

Publications for ABCC3 Gene

  1. Characterization of MOAT-C and MOAT-D, new members of the MRP/cMOAT subfamily of transporter proteins. (PMID: 9827529) Belinsky M.G. … Kruh G.D. (J. Natl. Cancer Inst. 1998) 2 3 4 22 64
  2. Functional reconstitution of human ABCC3 into proteoliposomes reveals a transport mechanism with positive cooperativity. (PMID: 19334674) Zehnpfennig B. … Galla H.J. (Biochemistry 2009) 3 22 25 64
  3. Genetic variations of the ABC transporter gene ABCC3 in a Japanese population. (PMID: 17495421) Fukushima-Uesaka H. … Sawada J. (Drug Metab. Pharmacokinet. 2007) 3 22 46 64
  4. Transport of glyburide by placental ABC transporters: implications in fetal drug exposure. (PMID: 16460798) Gedeon C. … Piquette-Miller M. (Placenta 2006) 3 22 25 64
  5. Transport of bile acids in multidrug-resistance-protein 3-overexpressing cells co-transfected with the ileal Na+-dependent bile-acid transporter. (PMID: 12220224) Zelcer N. … Borst P. (Biochem. J. 2003) 3 22 25 64

Products for ABCC3 Gene

  • Cloud-Clone Corp. Antibodies for ABCC3
  • Cloud-Clone Corp. Proteins for ABCC3
  • Cloud-Clone Corp Assay Kits for ABCC3

Sources for ABCC3 Gene

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