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ABCC3 Gene

protein-coding GIFtS: 65

GC17P046067

ATP-binding cassette, sub-family C (CFTR/MRP), member 3
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
ABC31 ^²
CMOAT2 ^³, ⁵
DKFZp686E22157 ^²
EST90757 ^¹, ²
MLP2 ^¹, ², ³, ⁵
MOAT-D ^¹, ², ³
MRP3 ^¹, ², ³, ⁵
cMOAT2 ^¹, ²

Descriptions
ATP-binding cassette sub-family C member 3 ^³
ATP-binding cassette, sub-family C (CFTR/MRP), member 3 ^²
ATP-binding cassette, sub-family C, member 3 ^²
Multi-specific organic anion transporter D ^³
Multidrug resistance-associated protein 3 ^³
canicular multispecific organic anion transporter ^²
multidrug resistance associated protein ^²

External Ids
HGNC: 54¹
Entrez Gene: 8714²
UniProtKB: O15438³
Ensembl: ENSG00000108846⁷

Search outside databases for aliases for ABCC3 gene

Previous GC identifers: GC17P048425 GC17P051193 GC17P049054 GC17P049186

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for ABCC3:

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC)

transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes.

ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20,

White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance.

The specific function of this protein has not yet been determined; however, this protein may play

a role in the transport of biliary and intestinal excretion of organic anions. Alternatively

spliced variants which encode different protein isoforms have been described; however, not all

variants have been fully characterized. [provided by RefSeq]

UniProtKB/Swiss-Prot: MRP3_HUMAN, O15438

Function: May act as an inducible transporter in the biliary and intestinal excretion of organic

anions. Acts as an alternative route for the export of bile acids and glucuronides from

cholestatic hepatocytes (By similarity)

Gene Wiki entry for ABCC3

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ABCC3 gene

Entrez Gene cytogenetic band: 17q22 Ensembl cytogenetic band: 17q21.33 HGNC cytogenetic band: 17q21

ABCC3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17P046067: (about GC identifiers)

Start:	46,067,227 bp from pter
End:	46,124,062 bp from pter
Size:	56,836 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000017.9 NT_010783.14

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: MRP3_HUMAN, O15438 (See protein sequence)

Recommended Name: Canalicular multispecific organic anion transporter 2

Size: 1527 amino acids; 169343 Da

Subcellular location: Membrane; Multi-pass membrane protein

Secondary accessions: O60265 O60922 O75621 O95078 O95289 O95290 Q9UN52

Alternative splicing: 4 isoforms: O15438-1 O15438-2 O15438-3 O15438-4 (Additional isoforms seem to exist)

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_001137542.1 NP_003777.2

ENSEMBL proteins:

ENSP00000285238

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (MRP3)
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005624	membrane fraction	TAS	9813153
GO:0005887	integral to plasma membrane	TAS	9813153
GO:0016020	membrane	IEA	--

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Antibodies for ABCC3:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for ABCC3
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (MRP3), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for ABCC3

Assays for ABCC3:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry O15438

ProtoNet protein and cluster: O15438

UniProtKB/Swiss-Prot: MRP3_HUMAN, O15438

Similarity: Belongs to the ABC transporter family. Conjugate transporter (TC 3.A.1.208) subfamily

Similarity: Contains 2 ABC transmembrane type-1 domains

Similarity: Contains 2 ABC transporter domains

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ABCC3)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ABCC3)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_003786

Applied Biosystems Silencer® siRNAs for ABCC3

Sigma-Aldrich siRNA and siRNA Panels for ABCC3

Sigma-Aldrich shRNA for ABCC3

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001144070
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001144070
untagged cDNA clones in CMV expression vector (see all 2): NM_001144070

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_003786

UniProtKB/Swiss-Prot: MRP3_HUMAN, O15438

Function: May act as an inducible transporter in the biliary and intestinal excretion of organic

anions. Acts as an alternative route for the export of bile acids and glucuronides from

cholestatic hepatocytes (By similarity)

Genatlas biochemistry entry for ABCC3:

ATP binding cassette superfamily,subfamily C (CFTR/MRP),member 3,expressed in liver,colon,small

intestine and prostate,involved in the adrenal glands,biliary and intestinal excretion of organic

anions

4 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Abcc3):

behavior/neurological

homeostasis/metabolism

liver/biliary system

touch/vibrissae

5/6 Gene Ontology (GO) molecular function terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0005215	transporter activity	IEA	--
GO:0005524	ATP binding	TAS	9813153
GO:0008514	organic anion transmembrane transporter activity	TAS	9738950
GO:0016887	ATPase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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4 Sigma-Aldrich "Your Favorite Gene" Pathways for ABCC3 (Your Favorite Gene powered by Ingenuity)

PXR/RXR Activation
Xenobiotic Metabolism Signaling
Hepatic Cholestasis
LPS/IL-1 Mediated Inhibition of RXR Function

GeneDecks ABCC3 for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for ABCC3

5/31 Interacting proteins for ABCC3 (ENSP00000285238³) via UniProtKB, MINT, and/or STRING (see all 31 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SLC10A1	ENSP00000216540³	STRING (score=.973)
SLCO1B1	ENSP00000256958³	STRING (score=.973)
SLCO1B3	ENSP00000370956³	STRING (score=.973)
SLC10A2	ENSP00000245312³	STRING (score=.972)
FABP6	ENSP00000312283³	STRING (score=.956)

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2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006810	transport	TAS	9813153
GO:0015722	canalicular bile acid transport	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for ABCC3
10/15 Novoseek chemical compound relationships for ABCC3 gene (see all 15 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
estradiol-17beta-glucuronide	89.51	6	10644759 (1), 14667926 (1), 12388190 (1), 12924948 (1)
etoposide glucuronide	83.64	6	11581266 (2), 12220224 (1)
5-carboxyfluorescein	70.45	3	14603501 (1), 14570758 (1)
androstane	66.44	2	14705863 (1)
glucuronide	61.57	3	14667926 (1), 14643890 (1)
bile acid	61.46	4	12220224 (1), 15814571 (1)
gamma-glutamylcysteine	46.16	2	11820781 (1), 11239498 (1)
sulfate	35.06	4	15083066 (1), 14643890 (1)
atp	34.24	4	19334674 (1), 10644759 (1), 18393293 (1)
ltc4	27.58	1	10987286 (1)

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5 PharmGKB drug compound relationships for ABCC3 gene

Drug compound	PharmGKB Relations	PubMed IDs for articles supporting these relationships
etoposide	FA	11581266
folic acid	FA	11585759
leucovorin	FA	11585759
methotrexate	PD FA	11585759 15630450
teniposide	FA	11581266

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ABCC3)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ABCC3)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_003786

Sigma-Aldrich siRNA and siRNA Panels for ABCC3

Sigma-Aldrich shRNA for ABCC3

Explore Sigma-Aldrich super-pooled esiRNAs

REFSEQ mRNAs for ABCC3 gene (2 alternative transcripts):

NM_001144070.1 NM_003786.3

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001144070
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001144070
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_001144070

Additional cDNA sequence:

AB010887.1 AB208954.1 AF009670.1 AF083552.1 AF085690.1 AF085692.1 AF104943.1 BC046126.1

BC050370.1 BC058907.1 BC104952.1 BC137347.1 BC137348.1 U66674.1 U83659.1 Y17151.2

24 DOTS entries:

DT.215229 DT.100789082 DT.100789080 DT.92436625 DT.40118229 DT.95148897 DT.91940550 DT.91972802

DT.92436630 DT.70105371 DT.444291 DT.86844736 DT.91940419 DT.95082800 DT.99950674 DT.121001282

DT.121001284 DT.40303139 DT.92436622 DT.95082810 DT.95259083 DT.100705669 DT.95082805 DT.95230357

24/233 AceView cDNA sequences (see all 233 ):

BU543489 AF085691 AF104943 AI887269 BC046126 CB055248 AI281129 BI761935

AA843535 CB138592 Y17151 BU543427 AW195226 AI832393 BQ227366 BM795857

BQ955138 BU631704 AI282631 AI916490 BM828847 BC050370 AF154001 BU620702

highest scoring ESTs for ABCC3:

AF085692 U83659 AA159305 AA384098 AA429895 AA446044 AA484778 AA534870 AA843535 AA852507

Unigene Cluster for ABCC3:

ATP-binding cassette, sub-family C (CFTR/MRP), member 3

Hs.463421 [show with all ESTs]

Unigene Representative Sequence: AF085692

GeneLoc Exon Structure

5/16 Alternative Splicing Database (ASD) splice patterns (SP) for ABCC3 (see all 16 )

ExUns:	1a	·	1b	·	1c	·	1d	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10a	·	10b	^	11	^	12	^	13	^	14	^	15	^	16a	·	16b	^	17a	·	17b	^	18	^	19	^	20a	·
SP1:									-		-		-												-						-
SP2:									-		-		-																		-
SP3:									-		-		-												-						-
SP4:									-		-		-												-						-
SP5:

ExUns:	20b	^	21	^	22	^	23a	·	23b	·	23c	·	23d	^	24a	·	24b	·	24c	^	25	^	26a	·	26b	·	26c	^	27	^	28a	·	28b	^	29a	·	29b	^	30	^	31a	·	31b	^	32a	·	32b	^	33a	·	33b	^
SP1:													-																												-				-						-
SP2:													-																												-				-						-
SP3:													-																												-				-						-
SP4:
SP5:																																	-

ExUns:	34	^	35a	·	35b	·	35c	^	36	^	37a	·	37b	·	37c	·	37d
SP1:			-		-				-
SP2:			-		-				-
SP3:			-		-				-
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for ABCC3

1 Ensembl transcript including schematic representation:

ENST00000285238

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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ABCC3 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ABCC3

¹ / ² / ³

16 probe-sets matching ABCC3 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
38261_at²^{, 3}	U95-A	1	1.00	1.00	0.96	0.97	AF085692	1.00	1.00	1.00	1
1930_at²^{, 3}	U95-A	1	1.00	1.00	0.97	0.86	U83659	1.00	1.00	1.00	1
63137_at²^{, 3}	U95-C	1	0.62	1.00	0.76	0.83	AI282631	0.60	1.00	0.82	1
67798_at²^{, 3}	U95-E	1	0.62	1.00	0.31	1.41	AI375341	0.60	1.00	0.82	1
214979_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AK000791	0.40	1.00	0.76	1
208161_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_020037	0.40	1.00	0.76	1
209641_s_at²^{, 3}	U133-A	2	1.00	0.95	--	--	AF009670	0.80	1.00	0.91	1
239217_x_at²^{, 3}	U133-B	10	0.91	0.86	--	--	AI375341	0.60	1.00	0.82	1
230682_x_at²^{, 3}	U133-B	1	0.64	1.00	--	--	BF515888	0.40	1.00	0.76	1
242553_at*²^{, 3}	U133-B	NULL	0.00	0.00	--	--	AW079749	0.20	1.00	0.72	1
214979_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
208161_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
209641_s_at²	U133Plus2	2	1.00	0.95	--	--	--	--	--	--	--
239217_x_at²	U133Plus2	10	0.91	0.86	--	--	--	--	--	--	--
230682_x_at²	U133Plus2	1	0.64	1.00	--	--	--	--	--	--	--
242553_at*²	U133Plus2	NULL	0.00	0.00	--	--	--	--	--	--	--

GeneDecks ABCC3 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GTCAACAGTA

SOURCE GeneReport for Unigene cluster: Hs.463421
Expression variation in blood from EXPOLDB for ABCC3
UniProtKB/Swiss-Prot: MRP3_HUMAN, O15438
Tissue specificity: Mainly expressed in the liver. Also expressed in small intestine, colon,
prostate, testis, brain and at a lower level in the kidney

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ABCC3 gene from 5/11 species (see all 11 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ABCC3¹	--	ATP-binding cassette, sub-family C (CFTR/MRP), member more	86.33(n) 84.82(a)	491084 XM_548204.2 XP_548204.2
chimpanzee (Pan troglodytes)	ABCC3¹	--	ATP-binding cassette, sub-family C (CFTR/MRP), member more	99.14(n) 98.74(a)	747938 XM_001158914.1 XP_001158914.1
cow (Bos taurus)	ABCC3¹	--	ATP-binding cassette, sub-family C (CFTR/MRP), member more	85.76(n) 84.75(a)	533151 XM_612461.3 XP_612461.3
rat (Rattus norvegicus)	Abcc3¹	--	ATP-binding cassette, sub-family C (CFTR/MRP), member more	81.63(n) 79.63(a)	140668 NM_080581.1 NP_542148.1
mouse (Mus musculus)	Abcc3^{1, 5}	11⁵	ATP-binding cassette, sub-family C (CFTR/MRP), member more^{1, 5}	82.42(n)¹ 81.07(a)¹	76408¹ NM_029600.3¹ NP_083876.3¹ AF534127⁵ AF534128⁵ (see all 19)

About this table Species with no ortholog for ABCC3

ENSEMBL Gene Tree for ABCC3

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for ABCC3 gene

ABCC6² ABCC1² ABCC2²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/345 NCBI SNPs in ABCC3 are shown (see all 345 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 131)

AB	SNP ID	Valid	Chr 17 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs1989983^1,2	A,C,F,H	46065530(+)	`cagagG/Acatca`	1	--	ng5¹		5		MN EU EA WA	604
	rs11568591^1,2	C,F,H	46116052(+)	`TGTGCG/ACTACC`	1	H/R	mis¹ ese³		12		NA EU EA WA	1532
	rs17563146^1,2	C,F,H	46124328(+)	`GTGAAC/TACCTC`	1	--	ng3¹		11		NA EU EA WA	980
	rs4793665^1,2	A,C	46067086(+)	`CCCCCC/TACCTC`	1	--	ng5¹		0	--	--	--	--
	rs11568590^1,2	F,H	46116448(+)	`CTCTCA/GGCTGA`	1	Q/R	mis¹ ese³		5		EU EA WA	496
--	rs45461799^1,2	C,F	46117096(+)	`CCCTGC/AGCATG`	1	S/R	mis¹		1		--	30
--	rs1003355^1,2	H	46100065(+)	`CACGGC/GGGCCT`	1	A/G	mis¹ ese³		5		MN EU EA WA	594
--	rs45617731^1,2	C	46093417(+)	`CATCAG/TTGCCT`	1	S/I	mis¹		1		--	550
	rs34291385^1,2	F	46105382(+)	`GAGCTG/CTTTAC`	1	L/V	mis¹		1		--	102
	rs11656685^1,2	H	46123514(+)	`TGCAGC/ATAGAG`	1	D/A	mis¹ ese³		4		EU EA WA	416

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HapMap Linkage Disequilibrium images for ABCC3 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 604323

10/28 Novoseek disease relationships for ABCC3 gene (see all 28 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
dubin-johnson syndrome	72.06	1	10094960 (1)
cholestasis	68.43	10	12837754 (1), 11850532 (1), 12538803 (1), 10728790 (1) (see all 7)
cholestasis extrahepatic	58.42	4	11076395 (1), 12428063 (1), 19185005 (1)
breast cancer	38.81	19	12731885 (2), 18393293 (2), 10739113 (1), 14979731 (1) (see all 16)
biliary cirrhosis primary	36.27	2	14568249 (1)
hepatocellular carcinoma	33.84	7	18250047 (3), 18619700 (2), 14599947 (1), 11745434 (1)
cancer	33.37	11	9270026 (1), 10359813 (1), 12676459 (1), 10100721 (1) (see all 11)
glioma	31.36	11	11223551 (5), 16193381 (4)
colon adenocarcinoma	29.94	1	17430634 (1)
nsclc	25.92	10	11410522 (2), 15014021 (1), 19345732 (1)

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1 PharmGKB disease relationship for ABCC3 gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Leukemia, Lymphocytic, Acute, L1	PD	15630450

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Human Gene Mutation Database: ABCC3
Human Genome Epidemiology Navigator: ABCC3 (5 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/215 PubMed articles for ABCC3 gene (see all 215 ):

Characterization of MOAT-C and MOAT-D, new members of the MRP/cMOAT subfamily of transporter proteins. (PubMed id 9827529)^{1, 2, 3, 4} Belinsky M.G....Kruh G.D. (1998)
Characterization of the human multidrug resistance protein isoform MRP3 localized to the basolateral hepatocyte membrane. (PubMed id 10094960)^{1, 3, 4} Koenig J.... Keppler D. (1999)
cDNA cloning and inducible expression of human multidrug resistance associated protein 3 (MRP3). (PubMed id 9738950)^{1, 3, 4} Kiuchi Y.... Sugiyama Y. (1998)
Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines. (PubMed id 9270026)^{1, 3, 4} Kool M.... Borst P. (1997)
An unappreciated role for RNA surveillance. (PubMed id 14759258)^{3, 4} Hillman R.T.... Brenner S.E. (2004)
Transport of methotrexate (MTX) and folates by multidrug resistance protein (MRP) 3 and MRP1: effect of polyglutamylation on MTX transport. (PubMed id 11585759)^{1, 7} Zeng H....Kruh G.D. (2001)
Characterization of drug transport by the human multidrug resistance protein 3 (ABCC3). (PubMed id 11581266)^{1, 7} Zelcer N....Borst P. (2001)
Human MRP3 transporter: identification of the 5'-flanking region, genomic organization and alternative splice variants. (PubMed id 9889399)^{3, 4} Fromm M.F.... Kim R.B. (1999)
Isolation of a novel human canalicular multispecific organic anion transporter, cMOAT2/MRP3, and its expression in cisplatin-resistant cancer cells with decreased ATP-dependent drug transport. (PubMed id 9813153)^{3, 4} Uchiumi T.... Kuwano M. (1998)
Characterization of the human ABC superfamily: isolation and mapping of 21 new genes using the expressed sequence tags database. (PubMed id 8894702)^{2, 3} Allikmets R....Dean M. (1996)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 8714	HGNC: 54	AceView: ABCC3	Ensembl:ENSG00000108846	euGenes: HUgn8714
ECgene: ABCC3	H-InvDB: ABCC3

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
ATLAS Chromosomes in Cancer entry for ABCC3	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for ABCC3
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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
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Products for ABCC3:

TaqMan ® Gene Expression Assays

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ABCC3 Gene

protein-coding GIFtS: 65

Aliases &
Descriptions
for ABCC3

Summaries
for ABCC3

Genomic Location
for ABCC3

Proteins
for ABCC3

Protein Domains/
Families
for ABCC3

Gene Function
for ABCC3

Pathways & Interactions
for ABCC3

Drugs & Compounds
for ABCC3

Transcripts
for ABCC3

Expression
for ABCC3

Orthologs
for ABCC3

Paralogs
for ABCC3

SNPs/Variants
for ABCC3

Disorders & Mutations
for ABCC3

Medical News
for ABCC3

Publications
for ABCC3

Search for ABCC3

Genome Databases showing ABCC3

Other Databases showing ABCC3

Specialized Databases showing ABCC3

Licensable Technologies
for ABCC3

Services
for ABCC3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ABCC3 Gene

protein-coding GIFtS: 65

Aliases & Descriptionsfor ABCC3

Summariesfor ABCC3

Genomic Locationfor ABCC3

Proteinsfor ABCC3

Protein Domains/Familiesfor ABCC3

Gene Functionfor ABCC3

Pathways & Interactionsfor ABCC3

Drugs & Compoundsfor ABCC3

Transcriptsfor ABCC3

Expression for ABCC3

Orthologsfor ABCC3

Paralogsfor ABCC3

SNPs/Variantsfor ABCC3

Disorders & Mutationsfor ABCC3

Medical Newsfor ABCC3

Publicationsfor ABCC3

Search for ABCC3

Genome Databases showing ABCC3

Other Databases showing ABCC3

Specialized Databases showing ABCC3

Licensable Technologiesfor ABCC3

Servicesfor ABCC3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ABCC3

Summaries
for ABCC3

Genomic Location
for ABCC3

Proteins
for ABCC3

Protein Domains/
Families
for ABCC3

Gene Function
for ABCC3

Pathways & Interactions
for ABCC3

Drugs & Compounds
for ABCC3

Transcripts
for ABCC3

Expression
for ABCC3

Orthologs
for ABCC3

Paralogs
for ABCC3

SNPs/Variants
for ABCC3

Disorders & Mutations
for ABCC3

Medical News
for ABCC3

Publications
for ABCC3

Licensable Technologies
for ABCC3

Services
for ABCC3