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ABCC3 Gene

protein-coding GIFtS: 69
GCID: GC17P048712

ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 3

See related diseases
at

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Aliases
ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 3¹ ²		ABC31²
MLP2² ³ ⁵		EST90757²
MRP3² ³ ⁵		cMOAT2²
Canalicular Multispecific Organic Anion Transporter 2¹ ²		Canicular Multispecific Organic Anion Transporter²
Multi-Specific Organic Anion Transporter D² ³		Multidrug Resistance Associated Protein²
Multidrug Resistance-Associated Protein 3² ³		EC 3.6.3⁸
MOAT-D² ³		EC 3.6.3.44⁸
ATP-Binding Cassette Sub-Family C Member 3² ³		EC 6.3.2.4⁸
CMOAT2³ ⁵

External Ids:	HGNC: 54¹	Entrez Gene: 8714²	Ensembl: ENSG00000108846⁷	OMIM: 604323⁵	UniProtKB: O15438³

Export aliases for ABCC3 gene to outside databases

Previous GC identifers: GC17P048425 GC17P051193 GC17P049054 GC17P049186 GC17P046067 GC17P044080

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ABCC3 Gene:

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC

proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven

distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily

which is involved in multi-drug resistance. The specific function of this protein has not yet been determined;

however, this protein may play a role in the transport of biliary and intestinal excretion of organic anions.

Alternatively spliced variants which encode different protein isoforms have been described; however, not all

variants have been fully characterized. (provided by RefSeq, Jul 2008)

GeneCards Summary for ABCC3 Gene:

ABCC3 (ATP-binding cassette, sub-family C (CFTR/MRP), member 3) is a protein-coding gene. Diseases associated with ABCC3 include cholangiolocellular carcinoma, and dubin-johnson syndrome. GO annotations related to this gene include ATPase activity, coupled to transmembrane movement of substances and organic anion transmembrane transporter activity. An important paralog of this gene is ABCC4.

UniProtKB/Swiss-Prot: MRP3_HUMAN, O15438

Function: May act as an inducible transporter in the biliary and intestinal excretion of organic anions. Acts as

an alternative route for the export of bile acids and glucuronides from cholestatic hepatocytes (By similarity)

Gene Wiki entry for ABCC3 Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:

NC_000017.11 NT_010783.16 NC_018928.2

Regulatory elements:

Regulatory transcription factor binding sites in the ABCC3 gene promoter:
COUP-TF1 GR Sp1 p53 GR-beta COUP HNF-4alpha2 HNF-4alpha1 COUP-TF GR-alpha
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ABCC3 promoter sequence

Search Chromatin IP Primers for ABCC3

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ABCC3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q22 Ensembl cytogenetic band: 17q21.33 HGNC cytogenetic band: 17q21

ABCC3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ABCC3 gene location

GeneLoc information about chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17P048712: view genomic region (about GC identifiers)

Start:	48,712,138 bp from pter	End:	48,769,613 bp from pter
Size:	57,476 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: MRP3_HUMAN, O15438 (See protein sequence)

Recommended Name: Canalicular multispecific organic anion transporter 2

Size: 1527 amino acids; 169343 Da

Sequence caution: Sequence=AAB71756.1; Type=Frameshift; Positions=1334, 1338; Sequence=AAD01430.1;

Type=Frameshift; Positions=355, 359, 361; Sequence=AAD38185.1; Type=Erroneous translation; Note=Wrong choice of

CDS;

Secondary accessions: B2RPA9 D3DTX9 O60265 O60922 O75621 O95078 O95289 O95290 Q86X85 Q9UN52

Alternative splicing: 5 isoforms: O15438-1 O15438-2 O15438-3 O15438-4 O15438-5 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ABCC3: NX_O15438

Explore proteomics data for ABCC3 at MOPED

Post-translational modifications:

Glycosylation² at Asn18, Asn1006, Asn1007

Modification sites at PhosphoSitePlus

4 DME Specific Peptides for ABCC3 (O15438)

SVGQRQL

GEIRIDG

ASTVGEI

LSGGQRQRV

See ABCC3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (2 alternative transcripts):

NP_001137542.1 NP_003777.2

ENSEMBL proteins:

ENSP00000422786 ENSP00000425697 ENSP00000395160 ENSP00000285238 ENSP00000427073

ENSP00000427521 ENSP00000424981 ENSP00000422058 ENSP00000421755

Reactome Protein details: O15438

ABCC3 Human Recombinant Protein Products:

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ABCC3 Antibody Products:

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ABCC3 Assay Products:

	Browse Kits and Assays available from EMD Millipore
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	Browse Enzo Life Sciences for kits & assays
	Cloud-Clone Corp. ELISAs for ABCC3 Cloud-Clone Corp. CLIAs for ABCC3

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:

ABCC: ATP binding cassette transporters / subfamily C

IUPHAR Guide to PHARMACOLOGY protein family classification: ABCC3

ABCC subfamily

Selected InterPro protein domains (see all 7):

IPR003439 ABC_transporter-like

IPR027417 P-loop_NTPase

IPR001140 ABC_transptr_TM_dom

IPR003593 AAA+_ATPase

IPR011527 ABC1_TM_dom

Graphical View of Domain Structure for InterPro Entry O15438

ProtoNet protein and cluster: O15438

UniProtKB/Swiss-Prot: MRP3_HUMAN, O15438

Similarity: Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208)

subfamily

Similarity: Contains 2 ABC transmembrane type-1 domains

Similarity: Contains 2 ABC transporter domains

ABCC3 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

UniProtKB/Swiss-Prot Summary: MRP3_HUMAN, O15438

Function: May act as an inducible transporter in the biliary and intestinal excretion of organic anions. Acts as

an alternative route for the export of bile acids and glucuronides from cholestatic hepatocytes (By similarity)

Genatlas biochemistry entry for ABCC3:

ATP binding cassette superfamily,subfamily C (CFTR/MRP),member 3,expressed in liver,colon,small intestine and

prostate,involved in the adrenal glands,biliary and intestinal excretion of organic anions

Enzyme Numbers (IUBMB): EC 6.3.2.4² EC 3.6.3.44² EC 3.6.3²

Gene Ontology (GO): Selected molecular function terms (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	--	--
GO:0005215	transporter activity	--	--
GO:0005524	ATP binding	IEA	--
GO:0008514	organic anion transmembrane transporter activity	TAS	9738950
GO:0016887	ATPase activity	--	--

ABCC3 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for ABCC3:

Increased circadian period len

4 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Abcc3):

behavior/neurological

homeostasis/metabolism

integument

liver/biliary system

ABCC3 for phenotypes About GeneDecksing

Animal Models:
MGI mouse knock-outs for ABCC3: Abcc3^tm1Kruh Abcc3^tm1Bor

inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ABCC3

inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ABCC3

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ABCC3

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ABCC3

miRNA Products:		miRTarBase miRNAs that target ABCC3: hsa-mir-192-5p (MIRT004155), hsa-mir-124-3p (MIRT022500), hsa-mir-335-5p (MIRT017472), hsa-mir-197-3p (MIRT003824)

		Block miRNA regulation of human, mouse, rat ABCC3 using miScript Target Protectors
		1 qRT-PCR Assays for microRNA that regulate ABCC3:
		hsa-miR-205*
		SwitchGear 3'UTR luciferase reporter plasmid: ABCC3 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for ABCC3
		Predesigned siRNA for gene silencing in human, mouse, rat ABCC3

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for ABCC3

Clone Products:		OriGene clones in human, mouse for ABCC3 (see all 12) OriGene ORF clones in mouse, rat for ABCC3 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): ABCC3 (NM_003786)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ABCC3
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ABCC3

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for ABCC3
		Browse ESI BIO Cell Lines and PureStem Progenitors for ABCC3

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ABCC3

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot

MRP3_HUMAN, O15438: Membrane; Multi-pass membrane protein

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
plasma membrane	4
nucleus	2
vacuole	2
cytoskeleton	1
extracellular	1
mitochondrion	1

About this image

Gene Ontology (GO): 4 cellular component terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	TAS	--
GO:0005887	integral component of plasma membrane	IEA	--
GO:0016020	membrane	TAS	9813153
GO:0016021	integral component of membrane	--	--

ABCC3 for ontologies About GeneDecksing

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for ABCC3 About (see all 13)

See pathways by source

SuperPath

Contained pathways About

ABC-family proteins mediated transport

ABC-family proteins mediated transport

0.69

ABC transporters

0.69

Pyrimidine metabolism

Fluoropyrimidine Activity

0.69

Fluoropyrimidine Pathway, Pharmacokinetics

0.69

Codeine and Morphine Pathway, Pharmacokinetics

Codeine and Morphine Pathway, Pharmacokinetics

0.33

Codeine and morphine metabolism

0.00

Synthesis of bile acids and bile salts

Bile acid and bile salt metabolism

0.73

Recycling of bile acids and salts

0.00

Metabolism

Metabolism

0.38

Metabolism of lipids and lipoproteins

0.37

Pathways by source See SuperPaths
Show all pathways

4 BioSystems Pathways for ABCC3

	Fluoropyrimidine Activity
	Codeine and morphine metabolism
	Nuclear receptors in lipid metabolism and toxicity
	Drug Induction of Bile Acid Pathway

2 Reactome Pathways for ABCC3

	ABC-family proteins mediated transport
	Recycling of bile acids and salts

Selected PharmGKB Pathways for ABCC3 (see all 6)

	Codeine and Morphine Pathway, Pharmacokinetics
	Etoposide Pathway, Pharmacokinetics/Pharmacodynamics
	Fluoropyrimidine Pathway, Pharmacokinetics
	Lamivudine Pathway, Pharmacokinetics/Pharmacodynamics
	Methotrexate Pathway, Pharmacokinetics

2 Kegg Pathways (Kegg details for ABCC3):

	ABC transporters
	Bile secretion

ABCC3 for pathways About GeneDecksing

Pathway & Disease-focused RT² Profiler PCR Arrays including ABCC3:

Drug Transporters in human mouse rat

Cancer Drug Resistance in human mouse rat

Hepatotoxicity in human mouse rat

Molecular Toxicology PathwayFinder 384HT in human mouse rat

Interactions:

GeneGlobe Interaction Network for ABCC3

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for ABCC3 (O15438³ ENSP00000285238⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 29)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
MLH1	P40692³	I2D: score=1
ALB	ENSP00000295897⁴	STRING: ENSP00000295897
FABP6	ENSP00000377549⁴	STRING: ENSP00000377549
SLC10A1	ENSP00000216540⁴	STRING: ENSP00000216540
SLC10A2	ENSP00000245312⁴	STRING: ENSP00000245312

About this table

Gene Ontology (GO): 5 biological process terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006810	transport	TAS	9813153
GO:0008206	bile acid metabolic process	TAS	--
GO:0015721	bile acid and bile salt transport	TAS	--
GO:0044281	small molecule metabolic process	TAS	--
GO:0055085	transmembrane transport	TAS	--

ABCC3 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for ABCC3 (MRP3)

Selected HMDB Compounds for ABCC3 (see all 85) About this table

Compound	Synonyms	CAS #	PubMed Ids
(3a,5b,7a)-23-Carboxy-7-hydroxy-24-norcholan-3-yl-b-D-Glucopyranosiduronic acid	Chenodeoxycholic acid 3-glucuronide (see all 3)	58814-71-4	--
1,3,12-Trihydroxycholan-24-oic acid	1,3,12-Trihydroxycholan-24-oate (see all 6)	63266-91-1	--
1,3,7,12-Tetrahydroxycholan-24-oic acid	1,3,7,12-Tetrahydroxycholan-24-oate (see all 10)	63266-89-7	--
12-Ketodeoxycholic acid	12-Dehydrodeoxycholate (see all 20)	5130-29-0	--
12a-Hydroxy-3-oxocholadienic acid	12a-Hydroxy-3-oxo-4,6-choladien-24-oate (see all 8)	13535-96-1	--
12b-Hydroxy-5b-cholanoic acid	12b-Hydroxy-5b-cholanic acid (see all 9)	15173-23-6	--
1b,3a,12a-Trihydroxy-5b-cholanoic acid	1,3,12-trihydroxy-(5b)-Cholan-24-oate (see all 6)	80434-32-8	--
1b,3a,7a-Trihydroxy-5b-cholanoic acid	1 beta,3a,7a-Trihydroxy-5b-cholanoate (see all 18)	99598-04-6	--
1b-Hydroxycholic acid	1b,3a,7a,12a-Tetrahydroxy-5b-cholan-24-oate (see all 5)	80875-94-1	--
2b,3a,7a,12a-Tetrahydroxy-5b-cholanoic acid	2b,3a,7a,12a-Tetrahydroxy-5b-cholan-24-oate (see all 7)	60696-60-8	--

Selected DrugBank Compounds for ABCC3 (see all 27) About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Methotrexate	Amethopterin (see all 12)	59-05-2	transporter	substrate inhibitor	11837698 11585759 10329726 12731885 12388190 19334674 10987286 12909565
Taurocholic Acid	--	81-24-3	transporter	substrate inhibitor	11837698 11585759 12924948 12220224 12909565 10644759
Phenobarbital	Fenobarbital (see all 7)	50-06-6	transporter	inducer	14570762 9738950 10712264 12920174
Etoposide	EPEG (see all 4)	33419-42-0	transporter	substrate inhibitor	11585759 19334674 11581266
Probenecid	--	57-66-9	transporter	inhibitor	11585759 11581266 12538836
Indomethacin	IMN (see all 9)	53-86-1	transporter	inhibitor	16460798 11581266
Leucovorin	Calcium folinate (see all 7)	1492-18-8	transporter	substrate	11585759 12874005
Cholic Acid	--	81-25-4	transporter	inhibitor	10644759
Cisplatin	CDDP (see all 7)	15663-27-1	transporter	inducer	11323161
Clotrimazole	Chlotrimazole (see all 2)	23593-75-1	transporter	inducer	14570758

Selected Novoseek inferred chemical compound relationships for ABCC3 gene (see all 45) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
estradiol-17beta-glucuronide	89.7	6	10644759 (1), 14667926 (1), 12388190 (1), 12924948 (1)
etoposide glucuronide	87.6	10	20028753 (3), 11581266 (2), 12220224 (1)
taurocholate	71.7	8	12220224 (3), 16637898 (1), 12388190 (1), 12763363 (1) (see all 5)
5-carboxyfluorescein	68.1	3	14603501 (1), 14570758 (1)
androstane	68	2	14705863 (1)
glycocholate	65.3	7	12220224 (3), 10987286 (1), 12388190 (1)
glucuronide	62.5	3	14667926 (1), 14643890 (1)
tbhq	60.3	1	11841785 (1)
bile acid	59.7	4	12220224 (1), 15814571 (1)
mk 571	59.2	1	14667926 (1)

5 PharmGKB related drug/compound annotations for ABCC3 gene About this table

Drug/compound	PharmGKB Annotation
cisplatin	CA
cyclophosphamide	CA
doxorubicin	CA
methotrexate	CA
vincristine	CA

ABCC3 for compounds About GeneDecksing

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for ABCC3 gene (4 alternative transcripts):

NM_001144070.1 NM_003786.3 NM_020037.1 NM_020038.1

Unigene Cluster for ABCC3:

ATP-binding cassette, sub-family C (CFTR/MRP), member 3

Hs.463421 [show with all ESTs]

Unigene Representative Sequence: AF085692

18 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000515707 ENST00000513511 ENST00000427699(uc002isk.4) ENST00000285238(uc002isl.3)

ENST00000502426 ENST00000505699 ENST00000515585 ENST00000513589 ENST00000571855(uc002ism.3)

ENST00000515070 ENST00000503304 ENST00000510633 ENST00000506464 ENST00000513745

ENST00000510891 ENST00000503337(uc002isn.3) ENST00000508929 ENST00000504586

miRNA Products:		Block miRNA regulation of human, mouse, rat ABCC3 using miScript Target Protectors
		1 qRT-PCR Assays for microRNA that regulate ABCC3:
		hsa-miR-205*
		SwitchGear 3'UTR luciferase reporter plasmid: ABCC3 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for ABCC3
		Predesigned siRNA for gene silencing in human, mouse, rat ABCC3

Clone Products:		OriGene clones in human, mouse for ABCC3 (see all 12) OriGene ORF clones in mouse, rat for ABCC3 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): ABCC3 (NM_003786)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ABCC3
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ABCC3

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for ABCC3
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat ABCC3
		QuantiTect SYBR Green Assays in human, mouse, rat ABCC3
		QuantiFast Probe-based Assays in human, mouse, rat ABCC3

Additional mRNA sequence:

AB010887.1 AB208954.1 AF009670.1 AF083552.1 AF085690.1 AF085692.1 AF104943.1 BC046126.1

BC050370.1 BC058907.1 BC104952.1 BC137347.1 BC137348.1 U66674.1 U83659.1 Y17151.2

23 DOTS entries:

DT.215229 DT.100789082 DT.100789080 DT.92436625 DT.40118229 DT.95148897 DT.91972802 DT.92436630

DT.70105371 DT.444291 DT.95082800 DT.99950674 DT.121001282 DT.121001284 DT.86844736 DT.92436622

DT.95082810 DT.100705669 DT.40303139 DT.91940419 DT.91940550 DT.95082805 DT.95230357

Selected AceView cDNA sequences (see all 233):

BU631704 BQ009190 AW195226 CA445870 BU620702 BC058907 AF154001 AF085691

BF515888 BC034683 AI282631 NM_003786 NM_020037 BX479469 AF085690 NM_020038

AF085692 AA548503 AW848421 AA937472 BC046126 AI281129 BQ084505 AA843535

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for ABCC3 (see all 16) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10a	·	10b	^	11	^	12	^	13	^	14	^	15	^	16a	·	16b	^	17a	·	17b	^	18	^	19	^	20a	·
SP1:									-		-		-												-						-
SP2:									-		-		-																		-
SP3:									-		-		-												-						-
SP4:									-		-		-												-						-
SP5:

ExUns:	20b	^	21	^	22	^	23a	·	23b	·	23c	·	23d	^	24a	·	24b	·	24c	^	25	^	26a	·	26b	·	26c	^	27	^	28a	·	28b	^	29a	·	29b	^	30	^	31a	·	31b	^	32a	·	32b	^	33a	·	33b	^
SP1:													-																												-				-						-
SP2:													-																												-				-						-
SP3:													-																												-				-						-
SP4:
SP5:																																	-

ExUns:	34	^	35a	·	35b	·	35c	^	36	^	37a	·	37b	·	37c	·	37d
SP1:			-		-				-
SP2:			-		-				-
SP3:			-		-				-
SP4:
SP5:

ECgene alternative splicing isoforms for ABCC3

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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ABCC3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: GTCAACAGTA

About this image

ABCC3 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database
selected tissues (see all 7) fully expand


Lung (Respiratory System)
Alveolar type II cells

Colon (Gastrointestinal Tract)

Pancreas (Endocrine System)

Liver (Hepatobiliary System)

Adrenal Gland (Endocrine System)

ABCC3 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

ABCC3 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.463421

UniProtKB/Swiss-Prot: MRP3_HUMAN, O15438

Tissue specificity: Mainly expressed in the liver. Also expressed in small intestine, colon, prostate, testis,

brain and at a lower level in the kidney

Pathway & Disease-focused RT² Profiler PCR Arrays including ABCC3:

Drug Transporters in human mouse rat

Cancer Drug Resistance in human mouse rat

Hepatotoxicity in human mouse rat

Molecular Toxicology PathwayFinder 384HT in human mouse rat

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of eukaryotes.

Orthologs for ABCC3 gene from Selected species (see all 23) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Abcc3^{1 , 5}	ATP-binding cassette, sub-family C (CFTR/MRP), member more^{1, 5}	82.45(n)¹ 81.07(a)¹		11 (58.90 cM)⁵ 76408¹ NM_029600.3¹ NP_083876.3¹ 94343298⁵
chicken (Gallus gallus)	Aves	ABCC3¹	ATP-binding cassette, sub-family C (CFTR/MRP), member more	67.8(n) 69.87(a)		422099 XM_420102.4 XP_420102.4
lizard (Anolis carolinensis)	Reptilia	ABCC3⁶	ATP-binding cassette, sub-family C (CFTR/MRP), mem...	68(a)	1 ↔ 1	2(117235167-117323370)
tropical clawed frog (Xenopus tropicalis)	Amphibia	BX732495.1²	--	71.32(n)		BX732495.1
zebrafish (Danio rerio)	Actinopterygii	ABCC3⁶	ATP-binding cassette, sub-family C (CFTR/MRP), mem...	62(a)	1 ↔ 1	12(892554-983336) ENSDARG00000077243
fruit fly (Drosophila melanogaster)	Insecta	CG6214³ MRP¹	xenobiotic-transporting ATPase³ Multidrug-Resistance like Protein 1¹	47(a) (best of 2)³ 57.2(n)¹ 51.44(a)¹		33F4³ 34686¹ NM_205976.2¹ NP_995698.1¹
worm (Caenorhabditis elegans)	Secernentea	mrp-2³ mrp-7¹	ATP-binding transport family³ mrp-7¹	45(a) (best of 4)³ 49.48(n)¹ 46.13(a)¹		X(599137-607953)³ 180289¹ NM_075411.4¹ NP_507812.3¹
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	YCF1¹	YCF1	46.78(n) 42.48(a)		851713 NP_010419.3
thale cress (Arabidopsis thaliana)	eudicotyledons	MRP10¹	MRP10	45.58(n) 36.03(a)		825444 NM_116135.2 NP_191829.1
rice (Oryza sativa)	Liliopsida	Os04g0209200¹	Os04g0209200	48.35(n) 38.15(a)		4335176 NM_001058786.1 NP_001052251.1

ENSEMBL Gene Tree for ABCC3 (if available)
TreeFam Gene Tree for ABCC3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for ABCC3 gene

ABCC4² ABCC12² ABCC1² ABCC8² ABCC5² ABCC6² ABCC2² ABCC9²

ABCC11²

Selected SIMAP similar genes for ABCC3 using alignment to 9 protein entries: MRP3_HUMAN (see all proteins) (see all similar genes):

MRP3 DKFZp781G125 DKFZp434I2115 ABCB4 ABCC1 CTFR

CFTR TAP1 MRP NG-TRA ABCC2 ABCC6

ABCC4 ABCC13 ABCC10 ABCC9 ABCC11 ABCC12

ABCC3 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 17 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs199474029^1,2	C	untested¹	48760785(+)	`AGTAGG/TTCTGT`	1	--	int¹		0	--	--	--	--
rs199473685^1,2	C	untested¹	48761077(+)	`CCTGGT/AGCTGA`	2	/E /V	mis¹		1		EU	1323
rs181250497^1,2		--	48710356(+)	`CGGTGG/TGTAGA`	2	--	us2k¹		0	--	--	--	--
rs185500048^1,2	C	--	48710360(+)	`GGGTAG/TACAAG`	2	--	us2k¹		0	--	--	--	--
rs189862650^1,2		--	48710518(+)	`AGAAAC/TGAAGT`	2	--	us2k¹		0	--	--	--	--
rs1989983^1,2	C,F,A,H	--	48710531(+)	`CAGAGG/ACATCA`	2	--	us2k¹		19		MN NS EA NA WA	2524
rs180703166^1,2		--	48710578(+)	`TGGAGA/GGGGAT`	2	--	us2k¹		0	--	--	--	--
rs186486709^1,2		--	48710653(+)	`TCATAA/TCTAAA`	2	--	us2k¹		0	--	--	--	--
rs191865493^1,2		--	48710673(+)	`AGGCAC/TGCCGT`	2	--	us2k¹		0	--	--	--	--
rs144259836^1,2		--	48710687(+)	`AAGGTA/GTAAAG`	2	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for ABCC3 (48712138 - 48769613 bp)

Structural Variations
Database of Genomic Variants (DGV) 6 variations for ABCC3: About this table

Variant ID	Type	Subtype	PubMed ID
esv2716038	CNV	Deletion	23290073
nsv2083	CNV	Insertion	18451855
dgv3230n71	CNV	Loss	21882294
nsv833477	CNV	Loss	17160897
dgv42n68	CNV	Loss	17160897
nsv908609	CNV	Gain	21882294

Human Gene Mutation Database (HGMD): ABCC3

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing ABCC3

DNA2.0 Custom Variant and Variant Library Synthesis for ABCC3

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 604323 OMIM disorders: --

Selected diseases for ABCC3 (see all 49):
About MalaCards

cholangiolocellular carcinoma dubin-johnson syndrome extrahepatic cholestasis obstructive jaundice

barrett esophagus/esophageal adenocarcinoma bilirubin metabolic disorder cholestasis colon adenocarcinoma

soft tissue sarcoma malignant glioma lynch syndrome primary biliary cirrhosis

barrett's esophagus malignant mesothelioma lung squamous cell carcinoma acute leukemia

lymphoblastic leukemia hepatocellular carcinoma adenocarcinoma glioblastoma multiforme

4 diseases from the University of Copenhagen DISEASES database for ABCC3:

Cholestasis Lung cancer Leukemia Bilirubin metabolic disorder

ABCC3 for disorders About GeneDecksing

Selected Novoseek inferred disease relationships for ABCC3 gene (see all 28) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
dubin-johnson syndrome	71.4	1	10094960 (1)
cholestasis	68.3	10	12837754 (1), 11850532 (1), 12538803 (1), 10728790 (1) (see all 7)
cholestasis extrahepatic	57.3	4	11076395 (1), 12428063 (1), 19185005 (1)
breast cancer	41.7	22	12731885 (2), 18393293 (2), 10739113 (1), 14979731 (1) (see all 18)
hepatocellular carcinoma	38	8	18250047 (3), 18619700 (2), 19956884 (1), 11745434 (1) (see all 5)
cancer	35.8	13	9270026 (1), 10359813 (1), 12676459 (1), 10100721 (1) (see all 13)
biliary cirrhosis primary	35	2	14568249 (1)
glioma	32.5	11	11223551 (5), 16193381 (4)
colon adenocarcinoma	28.4	1	17430634 (1)
colon cancer	28	5	19593667 (3), 11820781 (1)

Genetic Association Database (GAD): ABCC3
Human Genome Epidemiology (HuGE) Navigator: ABCC3 (13 documents)

Export disorders for ABCC3 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for ABCC3 gene, integrated from 10 sources (see all 282):
(articles sorted by number of sources associating them with ABCC3)

Utopia: connect your pdf to the dynamic
world of online information

Characterization of MOAT-C and MOAT-D, new members of the MRP/cMOAT subfamily of transporter proteins. (PubMed id 9827529)^{1, 2, 3, 9} Belinsky M.G.... Kruh G.D. (J. Natl. Cancer Inst. 1998)
cDNA cloning and inducible expression of human multidrug resistance associated protein 3 (MRP3). (PubMed id 9738950)^{1, 2, 7, 9} Kiuchi Y.... Sugiyama Y. (FEBS Lett. 1998)
Transport of bile acids in multidrug-resistance-protein 3-overexpressing cells co-transfected with the ileal Na+-dependent bile-acid transporter. (PubMed id 12220224)^{1, 7, 9} Zelcer N....Borst P. (Biochem. J. 2003)
Characterization of the human multidrug resistance protein isoform MRP3 localized to the basolateral hepatocyte membrane. (PubMed id 10094960)^{1, 2, 9} Koenig J.... Keppler D. (Hepatology 1999)
Functional reconstitution of human ABCC3 into proteoliposomes reveals a transport mechanism with positive cooperativity. (PubMed id 19334674)^{1, 7, 9} Zehnpfennig B....Galla H.J. (Biochemistry 2009)
Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines. (PubMed id 9270026)^{1, 2, 9} Kool M.... Borst P. (Cancer Res. 1997)
ATP-binding cassette C transporters in human pancreatic carcinoma cell lines. Upregulation in 5-fluorouracil-resistant cells. (PubMed id 19077464)^{1, 7, 9} Hagmann W....LAPhr J.M. (Pancreatology 2009)
Could polymorphisms in ATP-binding cassette C3/multidrug resistance associated protein 3 (ABCC3/MRP3) modify colorectal cancer risk? (PubMed id 18313914)^{1, 4, 9} Campa D....Canzian F. (Eur. J. Cancer 2008)
Genetic variations of the ABC transporter gene ABCC3 in a Japanese population. (PubMed id 17495421)^{1, 4, 9} Fukushima-Uesaka H....Sawada J. (Drug Metab. Pharmacokinet. 2007)
Polymorphisms in ABCG2, ABCC3 and CNT1 genes and their possible impact on chemotherapy outcome of lung cancer patients. (PubMed id 19107936)^{1, 4, 9} MA1ller P.J....Risch A. (Int. J. Cancer 2009)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 8714	HGNC: 54	AceView: ABCC3	Ensembl:ENSG00000108846	euGenes: HUgn8714
ECgene: ABCC3	Kegg: 8714	H-InvDB: ABCC3

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for ABCC3	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for ABCC3	Genetics and Cytogenetics in Oncology and Haematology
ABCMdb	http://abcmutations.hegelab.org/proteinDetails?uniprot_id=O15438

Intellectual Property for ABCC3 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for ABCC3 gene:
Search GeneIP for patents involving ABCC3

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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ABCC3 Gene

ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 3

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ABCC3 Gene

ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 3

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