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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ABCC3 Gene

protein-coding   GIFtS: 70
GCID: GC17P048712

ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 3
  46 related diseases
at
MalaCards
 

Aliases
for ABCC3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section
Aliases
ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 31 2     ABC312
MLP22 3 5     EST907572
MRP32 3 5     cMOAT22
Canalicular Multispecific Organic Anion Transporter 21 2     Canicular Multispecific Organic Anion Transporter2
Multi-Specific Organic Anion Transporter D2 3     Multidrug Resistance Associated Protein2
Multidrug Resistance-Associated Protein 32 3     EC 3.6.38
MOAT-D2 3     EC 3.6.3.448
ATP-Binding Cassette Sub-Family C Member 32 3     EC 6.3.2.48
CMOAT23 5     

External Ids:    HGNC: 541   Entrez Gene: 87142   Ensembl: ENSG000001088467   OMIM: 6043235   UniProtKB: O154383   

Export aliases for ABCC3 gene to outside databases

Previous GC identifers: GC17P048425 GC17P051193 GC17P049054 GC17P049186 GC17P046067 GC17P044080


Summaries
for ABCC3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ABCC3 Gene:
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC
proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven
distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily
which is involved in multi-drug resistance. The specific function of this protein has not yet been determined;
however, this protein may play a role in the transport of biliary and intestinal excretion of organic anions.
Alternatively spliced variants which encode different protein isoforms have been described; however, not all
variants have been fully characterized. (provided by RefSeq, Jul 2008)

GeneCards Summary for ABCC3 Gene: 
ABCC3 (ATP-binding cassette, sub-family C (CFTR/MRP), member 3) is a protein-coding gene. Diseases associated with ABCC3 include cholangiolocellular carcinoma, and extrahepatic cholestasis, and among its related super-pathways are Codeine and Morphine Pathway, Pharmacokinetics and ABC-family proteins mediated transport. GO annotations related to this gene include ATPase activity, coupled to transmembrane movement of substances and organic anion transmembrane transporter activity. An important paralog of this gene is ABCC4.

UniProtKB/Swiss-Prot: MRP3_HUMAN, O15438
Function: May act as an inducible transporter in the biliary and intestinal excretion of organic anions. Acts as
an alternative route for the export of bile acids and glucuronides from cholestatic hepatocytes (By similarity)

Gene Wiki entry for ABCC3 Gene


Genomic Views
for ABCC3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NT_010783.15  NC_018928.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ABCC3 gene promoter:
         COUP-TF1   GR   Sp1   p53   GR-beta   COUP   HNF-4alpha2   HNF-4alpha1   COUP-TF   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ABCC3 promoter sequence
   Search SABiosciences Chromatin IP Primers for ABCC3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ABCC3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q22   Ensembl cytogenetic band:  17q21.33   HGNC cytogenetic band: 17q21

ABCC3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ABCC3 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P048712:  view genomic region     (about GC identifiers)

Start:
 48,712,138 bp from pter      End:
 48,769,613 bp from pter
Size:
 57,476 bases      Orientation:
 plus strand

Proteins
for ABCC3 gene

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section
UniProtKB/Swiss-Prot: MRP3_HUMAN, O15438 (See protein sequence)
Recommended Name: Canalicular multispecific organic anion transporter 2  
Size: 1527 amino acids; 169343 Da
Subcellular location: Membrane; Multi-pass membrane protein
Sequence caution: Sequence=AAB71756.1; Type=Frameshift; Positions=1334, 1338; Sequence=AAD01430.1;
Type=Frameshift; Positions=355, 359, 361; Sequence=AAD38185.1; Type=Erroneous translation; Note=Wrong choice of
CDS;
Secondary accessions: B2RPA9 D3DTX9 O60265 O60922 O75621 O95078 O95289 O95290 Q86X85 Q9UN52
Alternative splicing: 5 isoforms:  O15438-1   O15438-2   O15438-3   O15438-4   O15438-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ABCC3: NX_O15438

Explore proteomics data for ABCC3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O15438

    • 4 DME Specific Peptides for ABCC3 (O15438)
     SVGQRQL  GEIRIDG  ASTVGEI  LSGGQRQRV 

    ABCC3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ABCC3 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001137542.1  NP_003777.2  

    ENSEMBL proteins: 
     ENSP00000422786   ENSP00000425697   ENSP00000395160   ENSP00000285238   ENSP00000427073  
     ENSP00000427521   ENSP00000424981   ENSP00000422058   ENSP00000421755  
    Reactome Protein details: O15438
    Human Recombinant Protein Products for ABCC3: 
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    OriGene Protein Over-expression Lysate for ABCC3
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for ABCC3
    GenScript Custom Purified and Recombinant Proteins Services for ABCC3
    Novus Biologicals ABCC3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ABCC3 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane IEA--
    GO:0016020membrane TAS9813153
    GO:0016021integral to membrane ----

    ABCC3 for ontologies           About GeneDecksing



    ABCC3 Antibody Products: 
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    Cloud-Clone Corp. ELISAs for ABCC3 
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    Protein Domains /
    Families
    for ABCC3 gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    		 HGNC Gene Families: 
    ABCC: ATP binding cassette transporters / subfamily C

    IUPHAR Guide to PHARMACOLOGY protein family classification: ABCC3 
    ABCC subfamily

    5/8 InterPro protein domains (see all 8):
     IPR003439 ABC_transporter-like
     IPR027417 P-loop_NTPase
     IPR001140 ABC_transptr_TM_dom
     IPR003593 AAA+_ATPase
     IPR017940 ABC_transporter_type1

    Graphical View of Domain Structure for InterPro Entry O15438

    ProtoNet protein and cluster: O15438

    UniProtKB/Swiss-Prot: MRP3_HUMAN, O15438
    Similarity: Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208)
    subfamily
    Similarity: Contains 2 ABC transmembrane type-1 domains
    Similarity: Contains 2 ABC transporter domains


    ABCC3 for domains           About GeneDecksing


    Function
    for ABCC3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MRP3_HUMAN, O15438
    Function: May act as an inducible transporter in the biliary and intestinal excretion of organic anions. Acts as
    an alternative route for the export of bile acids and glucuronides from cholestatic hepatocytes (By similarity)

         Genatlas biochemistry entry for ABCC3:
    ATP binding cassette superfamily,subfamily C (CFTR/MRP),member 3,expressed in liver,colon,small intestine and
    prostate,involved in the adrenal glands,biliary and intestinal excretion of organic anions

         Enzyme Numbers (IUBMB): EC 6.3.2.42 EC 3.6.3.442 EC 3.6.32

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding ----
    GO:0005215transporter activity ----
    GO:0005524ATP binding IEA--
    GO:0008514organic anion transmembrane transporter activity TAS9738950
    GO:0016887ATPase activity ----
         
    ABCC3 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ABCC3:
     Increased circadian period len 

         4 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Abcc3):
     behavior/neurological  homeostasis/metabolism  integument  liver/biliary system 

    ABCC3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for ABCC3: Abcc3tm1Kruh Abcc3tm1Bor

       inGenious Targeting Laboratory - Custom generated mouse model solutions for ABCC3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ABCC3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ABCC3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ABCC3 

    miRNA
    Products:            		miRTarBase miRNAs that target ABCC3:
    hsa-mir-192 (MIRT004155), hsa-mir-197 (MIRT003824)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ABCC3
    1 QIAGEN miScript miRNA Assays for microRNA that regulate ABCC3:
    hsa-miR-205*
    SwitchGear 3'UTR luciferase reporter plasmid: ABCC3 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ABCC3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ABCC3

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for ABCC3
    Sirion Biotech Customized adenovirus for overexpression of ABCC3

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for ABCC3 (see all 11)
    OriGene ORF clones in mouse, rat for ABCC3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ABCC3 (NM_003786)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ABCC3

    Cell Line
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    Search LifeMap BioReagents cell lines for ABCC3
    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ABCC3


    Pathways & Interactions
    for ABCC3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ABCC3 About   (see all 13)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Codeine and morphine metabolism
    		Codeine and morphine metabolism0.89
    		Codeine and Morphine Pathway, Pharmacokinetics0.89
    2ABC-family proteins mediated transport
    		ABC-family proteins mediated transport0.70
    		ABC transporters0.70
    3Fluoropyrimidine Activity
    		Fluoropyrimidine Activity0.69
    		Fluoropyrimidine Pathway, Pharmacokinetics0.69
    4Synthesis of bile acids and bile salts
    		Bile acid and bile salt metabolism0.74
    		Recycling of bile acids and salts0.35
    5Metabolism
    		Metabolism0.40
    		Metabolism of lipids and lipoproteins0.34

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    4 BioSystems Pathways for ABCC3
        Fluoropyrimidine Activity
    Codeine and morphine metabolism
    Nuclear receptors in lipid metabolism and toxicity
    Drug Induction of Bile Acid Pathway

    5/6        Reactome Pathways for ABCC3 (see all 6)
        ABC-family proteins mediated transport
    Transmembrane transport of small molecules
    Bile acid and bile salt metabolism
    Metabolism
    Recycling of bile acids and salts

    5/6 PharmGKB Pathways for ABCC3 (see all 6)
        Codeine and Morphine Pathway, Pharmacokinetics
    Etoposide Pathway, Pharmacokinetics/Pharmacodynamics
    Fluoropyrimidine Pathway, Pharmacokinetics
    Lamivudine Pathway, Pharmacokinetics/Pharmacodynamics
    Methotrexate Pathway, Pharmacokinetics

    2         Kegg Pathways  (Kegg details for ABCC3):
        ABC transporters
    Bile secretion


    ABCC3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ABCC3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    5/9 Interacting proteins for ABCC3 (O154383 ENSP000002852384) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MLH1P406923I2D: score=1 
    ALBENSP000002958974STRING: ENSP00000295897
    FABP6ENSP000003775494STRING: ENSP00000377549
    SLC10A1ENSP000002165404STRING: ENSP00000216540
    SLC10A2ENSP000002453124STRING: ENSP00000245312
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport TAS9813153
    GO:0008206bile acid metabolic process TAS--
    GO:0015721bile acid and bile salt transport TAS--
    GO:0044281small molecule metabolic process TAS--
    GO:0055085transmembrane transport TAS--

    ABCC3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ABCC3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ABCC3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ABCC3 (MRP3)

    10/85 HMDB Compounds for ABCC3 (see all 85)    About this table
    CompoundSynonyms CAS #PubMed Ids
    (3a,5b,7a)-23-Carboxy-7-hydroxy-24-norcholan-3-yl-b-D-Glucopyranosiduronic acidChenodeoxycholic acid 3-glucuronide (see all 3)58814-71-4--
    1,3,12-Trihydroxycholan-24-oic acid1,3,12-Trihydroxycholan-24-oate (see all 6)63266-91-1--
    1,3,7,12-Tetrahydroxycholan-24-oic acid1,3,7,12-Tetrahydroxycholan-24-oate (see all 10)63266-89-7--
    12-Ketodeoxycholic acid12-Dehydrodeoxycholate (see all 20)5130-29-0--
    12a-Hydroxy-3-oxocholadienic acid12a-Hydroxy-3-oxo-4,6-choladien-24-oate (see all 8)13535-96-1--
    12b-Hydroxy-5b-cholanoic acid12b-Hydroxy-5b-cholanic acid (see all 9)15173-23-6--
    1b,3a,12a-Trihydroxy-5b-cholanoic acid1,3,12-trihydroxy-(5b)-Cholan-24-oate (see all 6)80434-32-8--
    1b,3a,7a-Trihydroxy-5b-cholanoic acid1 beta,3a,7a-Trihydroxy-5b-cholanoate (see all 18)99598-04-6--
    1b-Hydroxycholic acid1b,3a,7a,12a-Tetrahydroxy-5b-cholan-24-oate (see all 5)80875-94-1--
    2b,3a,7a,12a-Tetrahydroxy-5b-cholanoic acid2b,3a,7a,12a-Tetrahydroxy-5b-cholan-24-oate (see all 7)60696-60-8--

    10/27 DrugBank Compounds for ABCC3 (see all 27)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    MethotrexateAmethopterin (see all 12)59-05-2transportersubstrate inhibitor11837698 11585759 10329726 12731885 12388190 19334674 10987286 12909565
    Taurocholic Acid-- 81-24-3transportersubstrate inhibitor11837698 11585759 12924948 12220224 12909565 10644759
    PhenobarbitalFenobarbital (see all 7)50-06-6transporterinducer14570762 9738950 10712264 12920174
    EtoposideEPEG (see all 4)33419-42-0transportersubstrate inhibitor11585759 19334674 11581266
    Probenecid-- 57-66-9transporterinhibitor11585759 11581266 12538836
    IndomethacinIMN (see all 9)53-86-1transporterinhibitor16460798 11581266
    LeucovorinCalcium folinate (see all 7)1492-18-8transportersubstrate11585759 12874005
    Cholic Acid-- 81-25-4transporterinhibitor10644759
    CisplatinCDDP (see all 7)15663-27-1transporterinducer11323161
    ClotrimazoleChlotrimazole (see all 2)23593-75-1transporterinducer14570758

    10/45 Novoseek inferred chemical compound relationships for ABCC3 gene (see all 45)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    estradiol-17beta-glucuronide 89.7 6 10644759 (1), 14667926 (1), 12388190 (1), 12924948 (1)
    etoposide glucuronide 87.6 10 20028753 (3), 11581266 (2), 12220224 (1)
    taurocholate 71.7 8 12220224 (3), 16637898 (1), 12388190 (1), 12763363 (1) (see all 5)
    5-carboxyfluorescein 68.1 3 14603501 (1), 14570758 (1)
    androstane 68 2 14705863 (1)
    glycocholate 65.3 7 12220224 (3), 10987286 (1), 12388190 (1)
    glucuronide 62.5 3 14667926 (1), 14643890 (1)
    tbhq 60.3 1 11841785 (1)
    bile acid 59.7 4 12220224 (1), 15814571 (1)
    mk 571 59.2 1 14667926 (1)

    5 PharmGKB related drug/compound annotations for ABCC3 gene    About this table
    Drug/compound PharmGKB Annotation
    cisplatinCA  
    cyclophosphamideCA  
    doxorubicinCA  
    methotrexateCA  
    vincristineCA  

    Search CenterWatch for drugs/clinical trials and news about ABCC3 / MRP3

    Transcripts
    for ABCC3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ABCC3 gene (4 alternative transcripts): 
    NM_001144070.1  NM_003786.3  NM_020037.1  NM_020038.1  

    Unigene Cluster for ABCC3:

    ATP-binding cassette, sub-family C (CFTR/MRP), member 3
    Hs.463421  [show with all ESTs]
    Unigene Representative Sequence: AF085692
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000515707 ENST00000513511 ENST00000427699(uc002isk.4) ENST00000285238(uc002isl.3)
    ENST00000502426 ENST00000505699 ENST00000515585 ENST00000513589 ENST00000571855(uc002ism.3)
    ENST00000515070 ENST00000503304 ENST00000510633 ENST00000506464 ENST00000513745
    ENST00000510891 ENST00000503337(uc002isn.3) ENST00000508929 ENST00000504586

    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate ABCC3:
    hsa-miR-205*
    SwitchGear 3'UTR luciferase reporter plasmid: ABCC3 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for ABCC3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ABCC3
    Clone
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    OriGene ORF clones in mouse, rat for ABCC3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ABCC3 (NM_003786)
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ABCC3

    Additional mRNA sequence: 

    AB010887.1 AB208954.1 AF009670.1 AF083552.1 AF085690.1 AF085692.1 AF104943.1 BC046126.1 
    BC050370.1 BC058907.1 BC104952.1 BC137347.1 BC137348.1 U66674.1 U83659.1 Y17151.2 

    23 DOTS entries:

    DT.215229  DT.100789082  DT.100789080  DT.92436625  DT.40118229  DT.95148897  DT.91972802  DT.92436630 
    DT.70105371  DT.444291  DT.95082800  DT.99950674  DT.121001282  DT.121001284  DT.86844736  DT.92436622 
    DT.95082810  DT.100705669  DT.40303139  DT.91940419  DT.91940550  DT.95082805  DT.95230357 

    24/233 AceView cDNA sequences (see all 233):

    BU543427 AI282631 BQ009190 AI916490 CB055248 AF085692 AA937472 AW269633 
    NM_003786 AF104943 AI887269 NM_020037 BQ084505 AA843535 AW848421 AI832393 
    AF085691 BQ227366 CA445870 AL709936 AW195226 BM852191 NM_020038 BG328614 

    GeneLoc Exon Structure

    5/16 Alternative Splicing Database (ASD) splice patterns (SP) for ABCC3 (see all 16)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17a · 17b ^ 18 ^ 19 ^ 20a ·
    SP1:                          -     -     -                                   -                 -                                                               
    SP2:                          -     -     -                                                     -                                                               
    SP3:                          -     -     -                                   -                 -                                                               
    SP4:                          -     -     -                                   -                 -                                                               
    SP5:                                                                                                                                                            

    ExUns: 20b ^ 21 ^ 22 ^ 23a · 23b · 23c · 23d ^ 24a · 24b · 24c ^ 25 ^ 26a · 26b · 26c ^ 27 ^ 28a · 28b ^ 29a · 29b ^ 30 ^ 31a · 31b ^ 32a · 32b ^ 33a · 33b ^
    SP1:                                      -                                                                                   -           -                 -   
    SP2:                                      -                                                                                   -           -                 -   
    SP3:                                      -                                                                                   -           -                 -   
    SP4:                                                                                                                                                            
    SP5:                                                                                                  -                                                         

    ExUns: 34 ^ 35a · 35b · 35c ^ 36 ^ 37a · 37b · 37c · 37d
    SP1:        -     -           -                           
    SP2:        -     -           -                           
    SP3:        -     -           -                           
    SP4:                                                      
    SP5:                                                      


    ECgene alternative splicing isoforms for ABCC3

    Expression
    for ABCC3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ABCC3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTCAACAGTA
    ABCC3 Expression
    About this image


    See ABCC3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ABCC3

    SOURCE GeneReport for Unigene cluster: Hs.463421

    UniProtKB/Swiss-Prot: MRP3_HUMAN, O15438
    Tissue specificity: Mainly expressed in the liver. Also expressed in small intestine, colon, prostate, testis,
    brain and at a lower level in the kidney

        SABiosciences Expression via Pathway-Focused PCR Arrays including ABCC3: 
              Drug Transporters in human mouse rat
              Cancer Drug Resistance in human mouse rat
              Hepatotoxicity in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

    Primer
    Products:    		OriGene qSTAR qPCR primer pairs in human, mouse for ABCC3
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ABCC3
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    In Situ
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    Orthologs
    for ABCC3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ABCC3 gene from 9/17 species (see all 17)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Abcc31 , 5 ATP-binding cassette, sub-family C (CFTR/MRP), member more1, 5 82.42(n)1
    81.07(a)1    		   11 (58.90 cM)5
    764081  NM_029600.31  NP_083876.31 
     943432985 
    chicken
    (Gallus gallus)    		 Aves ABCC31 ATP-binding cassette, sub-family C (CFTR/MRP), member more 67.6(n)
    69.65(a)    		   422099  XM_420102.3  XP_420102.3 
    lizard
    (Anolis carolinensis)    		 Reptilia ABCC36
    		 ATP-binding cassette, sub-family C (CFTR/MRP), mem...
    		 67(a)
    		 1 ↔ 1
    		 2(117235167-117323370)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia BX732495.12   -- 71.32(n)    BX732495.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii ABCC36
    		 ATP-binding cassette, sub-family C (CFTR/MRP), mem...
    		 62(a)
    		 1 ↔ 1
    		 12(892554-983336)
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG62143
    MRP1    		 xenobiotic-transporting ATPase3
    Multidrug-Resistance like Protein 11    		 47(a)
    (best of 2)3
    56.85(n)1
    51.24(a)1    		   33F43
    346861  NM_205973.11  NP_995695.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea mrp-23
    mrp-41    		 ATP-binding transport family3
    Protein MRP-41    		 45(a)
    (best of 4)3
    50.51(n)1
    44.33(a)1    		   X(599137-607953)3
    1812021  NM_077257.31  NP_509658.11 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons MRP101 ABC transporter C family member 14 45.61(n)
    35.8(a)    		   825444  NM_116135.2  NP_191829.1 
    rice
    (Oryza sativa)    		 Liliopsida Os04g02092001 hypothetical protein 48.04(n)
    37.6(a)    		   4335176  NM_001058786.1  NP_001052251.1 


    ENSEMBL Gene Tree for ABCC3 (if available)
    TreeFam Gene Tree for ABCC3 (if available)

    Paralogs
    for ABCC3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ABCC3 gene
    ABCC42  ABCC122  ABCC102  ABCC12  CFTR2  ABCC82  ABCC52  ABCC22  
    ABCC112  ABCC92  
    18/20 SIMAP similar genes for ABCC3 using alignment to 9 protein entries:     MRP3_HUMAN (see all proteins) (see all similar genes):
    MRP3    DKFZp781G125    DKFZp434I2115    ABCB4    ABCC1    CTFR
    CFTR    TAP1    MRP    NG-TRA    ABCC2    ABCC6
    ABCC4    ABCC13    ABCC10    ABCC9    ABCC11    ABCC12

    ABCC3 for paralogs           About GeneDecksing



    Genomic Variants
    for ABCC3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1521 SNPs in ABCC3 are shown (see all 1521)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 17 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1994740291,2
    		Cuntested148760785(+) AGTAGG/TTCTGT 1 -- int10--------
    rs1994736851,2
    		Cuntested148761077(+) CCTGGT/AGCTGA 2 /E /V mis11Minor allele frequency- A:0.00EU 1323
    rs1812504971,2
    		--48710356(+) CGGTGG/TGTAGA 2 -- us2k10--------
    rs1855000481,2
    		C--48710360(+) GGGTAG/TACAAG 2 -- us2k10--------
    rs1898626501,2
    		--48710518(+) AGAAAC/TGAAGT 2 -- us2k10--------
    rs19899831,2
    		C,F,A,H--48710531(+) CAGAGG/ACATCA 2 -- us2k119Minor allele frequency- A:0.22MN NS EA NA WA 2524
    rs1807031661,2
    		--48710578(+) TGGAGA/GGGGAT 2 -- us2k10--------
    rs1864867091,2
    		--48710653(+) TCATAA/TCTAAA 2 -- us2k10--------
    rs1918654931,2
    		--48710673(+) AGGCAC/TGCCGT 2 -- us2k10--------
    rs1442598361,2
    		--48710687(+) AAGGTA/GTAAAG 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for ABCC3 (48712138 - 48769613 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for ABCC3:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2716038CNV Deletion23290073
    nsv2083CNV Insertion18451855
    dgv3230n71CNV Loss21882294
    nsv833477CNV Loss17160897
    dgv42n68CNV Loss17160897
    nsv908609CNV Gain21882294


    Human Gene Mutation Database (HGMD): ABCC3
    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ABCC3
    DNA2.0 Custom Variant and Variant Library Synthesis for ABCC3

    Disorders / Diseases
    for ABCC3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    		 OMIM gene information: 604323    OMIM disorders: --

    20/46 diseases for ABCC3 (see all 46):    About MalaCards
    cholangiolocellular carcinoma    extrahepatic cholestasis    dubin-johnson syndrome    obstructive jaundice
    cholestasis    colon adenocarcinoma    jaundice    soft tissue sarcoma
    malignant glioma    esophageal adenocarcinoma    primary biliary cirrhosis    barrett's esophagus
    non-small cell lung carcinoma    malignant mesothelioma    acute leukemia    lymphoblastic leukemia
    hepatocellular carcinoma    adenocarcinoma    colon cancer    acute myeloid leukemia

    4 diseases from the University of Copenhagen DISEASES database for ABCC3:
    Cholestasis     Lung cancer     Leukemia     Bilirubin metabolic disorder

    ABCC3 for disorders           About GeneDecksing

    10/28 Novoseek inferred disease relationships for ABCC3 gene (see all 28)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    dubin-johnson syndrome 71.4 1 10094960 (1)
    cholestasis 68.3 10 12837754 (1), 11850532 (1), 12538803 (1), 10728790 (1) (see all 7)
    cholestasis extrahepatic 57.3 4 11076395 (1), 12428063 (1), 19185005 (1)
    breast cancer 41.7 22 12731885 (2), 18393293 (2), 10739113 (1), 14979731 (1) (see all 18)
    hepatocellular carcinoma 38 8 18250047 (3), 18619700 (2), 19956884 (1), 11745434 (1) (see all 5)
    cancer 35.8 13 9270026 (1), 10359813 (1), 12676459 (1), 10100721 (1) (see all 13)
    biliary cirrhosis primary 35 2 14568249 (1)
    glioma 32.5 11 11223551 (5), 16193381 (4)
    colon adenocarcinoma 28.4 1 17430634 (1)
    colon cancer 28 5 19593667 (3), 11820781 (1)

    Genetic Association Database (GAD): ABCC3
    Human Genome Epidemiology (HuGE) Navigator: ABCC3 (13 documents)

    Export disorders for ABCC3 gene to outside databases

    Publications
    for ABCC3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ABCC3 gene, integrated from 9 sources (see all 280):
    (articles sorted by number of sources associating them with ABCC3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of MOAT-C and MOAT-D, new members of the MRP/cMOAT subfamily of transporter proteins. (PubMed id 9827529)1, 2, 3, 9 Belinsky M.G.... Kruh G.D. (1998)
    2. cDNA cloning and inducible expression of human multidrug resistance associated protein 3 (MRP3). (PubMed id 9738950)1, 2, 7, 9 Kiuchi Y.... Sugiyama Y. (1998)
    3. Transport of bile acids in multidrug-resistance-protein 3-overexpressing cells co-transfected with the ileal Na+-dependent bile-acid transporter. (PubMed id 12220224)1, 7, 9 Zelcer N....Borst P. (2003)
    4. Characterization of the human multidrug resistance protein isoform MRP3 localized to the basolateral hepatocyte membrane. (PubMed id 10094960)1, 2, 9 Koenig J.... Keppler D. (1999)
    5. Functional reconstitution of human ABCC3 into proteoliposomes reveals a transport mechanism with positive cooperativity. (PubMed id 19334674)1, 7, 9 Zehnpfennig B....Galla H.J. (2009)
    6. Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines. (PubMed id 9270026)1, 2, 9 Kool M.... Borst P. (1997)
    7. ATP-binding cassette C transporters in human pancreatic carcinoma cell lines. Upregulation in 5-fluorouracil-resistant cells. (PubMed id 19077464)1, 7, 9 Hagmann W....LAPhr J.M. (2009)
    8. Could polymorphisms in ATP-binding cassette C3/multidrug resistance associated protein 3 (ABCC3/MRP3) modify colorectal cancer risk? (PubMed id 18313914)1, 4, 9 Campa D....Canzian F. (2008)
    9. Genetic variations of the ABC transporter gene ABCC3 in a Japanese population. (PubMed id 17495421)1, 4, 9 Fukushima-Uesaka H....Sawada J. (2007)
    10. Polymorphisms in ABCG2, ABCC3 and CNT1 genes and their possible impact on chemotherapy outcome of lung cancer patients. (PubMed id 19107936)1, 4, 9 MA1ller P.J....Risch A. (2009)

    External Searches for ABCC3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing ABCC3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8714 HGNC: 54 AceView: ABCC3 Ensembl:ENSG00000108846 euGenes: HUgn8714
    ECgene: ABCC3 Kegg: 8714 H-InvDB: ABCC3

    Other Databases showing ABCC3 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ABCC3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ABCC3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ABCC3 Genetics and Cytogenetics in Oncology and Haematology
    ABCMdbhttp://abcmutations.hegelab.org/proteinDetails?uniprot_id=O15438

    Intellectual Property
    for ABCC3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ABCC3 gene:
    Search GeneIP for patents involving ABCC3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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