Aliases for ABCC3 Gene
Aliases for ABCC3 Gene
- ATP Binding Cassette Subfamily C Member 3 2 3 5
- ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 3 2 3
- Canalicular Multispecific Organic Anion Transporter 2 2 3
- Multi-Specific Organic Anion Transporter D 3 4
- ATP-Binding Cassette Sub-Family C Member 3 3 4
- Multidrug Resistance-Associated Protein 3 3 4
- CMOAT2 3 4
- MOAT-D 3 4
- MLP2 3 4
External Ids for ABCC3 Gene
- HGNC: 54
- Entrez Gene: 8714
- Ensembl: ENSG00000108846
- OMIM: 604323
- UniProtKB: O15438
Previous GeneCards Identifiers for ABCC3 Gene
- GC17P048425
- GC17P051193
- GC17P049054
- GC17P049186
- GC17P046067
- GC17P048712
- GC17P044080
Summaries for ABCC3 Gene
-
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The specific function of this protein has not yet been determined; however, this protein may play a role in the transport of biliary and intestinal excretion of organic anions. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]
GeneCards Summary for ABCC3 Gene
ABCC3 (ATP Binding Cassette Subfamily C Member 3) is a Protein Coding gene. Diseases associated with ABCC3 include Dubin-Johnson Syndrome and Extrahepatic Cholestasis. Among its related pathways are Metabolism and Codeine and Morphine Pathway, Pharmacokinetics. GO annotations related to this gene include transporter activity and ATPase activity, coupled to transmembrane movement of substances. An important paralog of this gene is ABCC2.
UniProtKB/Swiss-Prot for ABCC3 Gene
-
May act as an inducible transporter in the biliary and intestinal excretion of organic anions. Acts as an alternative route for the export of bile acids and glucuronides from cholestatic hepatocytes (By similarity).
No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ABCC3 Gene
Genomics for ABCC3 Gene
Regulatory Elements for ABCC3 Gene
Enhancers for ABCC3 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around ABCC3 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the ABCC3 gene promoter:
Regulatory Element Products
Genomic Location for ABCC3 Gene
- Chromosome:
- 17
- Start:
- 50,634,777 bp from pter
- End:
- 50,692,252 bp from pter
- Size:
- 57,476 bases
- Orientation:
- Plus strand
Genomic View for ABCC3 Gene
Genes around ABCC3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q21.33 by Ensembl
- 17q21.33 by Entrez Gene
- 17q21.33 by HGNC
ABCC3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ABCC3 Gene
Proteins for ABCC3 Gene
-
Protein details for ABCC3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O15438-MRP3_HUMAN
- Recommended name:
- Canalicular multispecific organic anion transporter 2
- Protein Accession:
- O15438
- B2RPA9
- D3DTX9
- O60265
- O60922
- O75621
- O95078
- O95289
- O95290
- Q86X85
- Q9UN52
Protein attributes for ABCC3 Gene
- Size:
- 1527 amino acids
- Molecular mass:
- 169343 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=AAB71756.1; Type=Frameshift; Positions=1334, 1338; Evidence={ECO:0000305}; Sequence=AAD01430.1; Type=Frameshift; Positions=355, 359, 361; Evidence={ECO:0000305}; Sequence=AAD38185.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};
Protein Expression for ABCC3 Gene
Selected DME Specific Peptides for ABCC3 Gene
- O15438:
-
- SVGQRQL
- GEIRIDG
- LSGGQRQRV
- ASTVGEI
Post-translational modifications for ABCC3 Gene
Other Protein References for ABCC3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Cell Signaling Technology (CST) Antibodies for ABCC3 (ABCC3)
-
Custom Antibody ServicesOriGene Antibodies for ABCC3
- Novus Biologicals Antibodies for ABCC3
-
Cloud-Clone Corp. Antibodies for ABCC3
- Invitrogen Antibodies for ABCC3
- antibodies-online Antibodies for ABCC3: See all 75
- GeneTex ABCC3 antibody for ABCC3
-
St John's Laboratory Antibodies for ABCC3
-
Santa Cruz Biotechnology (SCBT) Antibodies for ABCC3
Protein Products
-
OriGene Purified Proteins for ABCC3
- Search Origene for MassSpec and Protein Over-expression Lysates for ABCC3
- Origene Custom Protein Services for ABCC3
-
Cloud-Clone Corp. Proteins for ABCC3
- Search GeneTex for Proteins for ABCC3
Domains & Families for ABCC3 Gene
Gene Families for ABCC3 Gene
- HGNC:
- IUPHAR :
Protein Domains for ABCC3 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for ABCC3 Gene
Graphical View of Domain Structure for InterPro Entry
O15438UniProtKB/Swiss-Prot:
MRP3_HUMAN :- Contains 2 ABC transmembrane type-1 domains.
- Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
- Domain:
-
- Contains 2 ABC transmembrane type-1 domains.
- Contains 2 ABC transporter domains.
- Family:
-
- Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
Function for ABCC3 Gene
Molecular function for ABCC3 Gene
- GENATLAS Biochemistry:
- ATP binding cassette superfamily,subfamily C (CFTR/MRP),member 3,expressed in liver,colon,small intestine and prostate,involved in the adrenal glands,biliary and intestinal excretion of organic anions
- UniProtKB/Swiss-Prot Function:
- May act as an inducible transporter in the biliary and intestinal excretion of organic anions. Acts as an alternative route for the export of bile acids and glucuronides from cholestatic hepatocytes (By similarity).
Enzyme Numbers (IUBMB) for ABCC3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005215 | transporter activity | IEA | -- |
| GO:0005524 | ATP binding | IEA | -- |
| GO:0008514 | organic anion transmembrane transporter activity | TAS | 9738950 |
| GO:0015432 | bile acid-exporting ATPase activity | TAS | -- |
| GO:0016887 | ATPase activity | IEA | -- |
Phenotypes for ABCC3 Gene
- MGI mutant phenotypes for ABCC3:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for ABCC3:
Animal Model Products
-
Taconic Biosciences Mouse Models for ABCC3
- Cyagen custom Knockout/knockin (KOKI) mouse models for ABCC3
-
-
ViGene Biosciences lentiviral particle packaged cDNA for ABCC3 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for ABCC3 gene
- Search ViGene Biosciences for ABCC3
CRISPR Products
-
OriGene CRISPR knockouts for ABCC3
- GenScript: Design CRISPR guide RNA sequences for ABCC3
miRNA for ABCC3 Gene
- miRTarBase miRNAs that target ABCC3
miRNA Products
- Search ViGene Biosciences for ABCC3
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for ABCC3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ABCC3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for ABCC3
-
ViGene Biosciences adenoviral particle packaged cDNA for ABCC3 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for ABCC3 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for ABCC3 gene
Flow Cytometry Products
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ABCC3 Gene
Localization for ABCC3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ABCC3 Gene
- Membrane; Multi-pass membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| nucleus | 2 |
| cytoskeleton | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0005887 | integral component of plasma membrane | IEA | -- |
| GO:0016020 | membrane | IEA,TAS | 9813153 |
| GO:0016021 | integral component of membrane | IEA | -- |
Pathways & Interactions for ABCC3 Gene
Pathways by source for ABCC3 Gene
1 Cell Signaling Technology pathway for ABCC3 Gene
4 BioSystems pathways for ABCC3 Gene
6 Reactome pathways for ABCC3 Gene
8 PharmGKB pathways for ABCC3 Gene
3 KEGG pathways for ABCC3 Gene
2 R&D Systems pathways for ABCC3 Gene
Interacting Proteins for ABCC3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006810 | transport | IEA,TAS | 9813153 |
| GO:0015721 | bile acid and bile salt transport | TAS | -- |
| GO:0055085 | transmembrane transport | IEA,TAS | -- |
| GO:0098656 | anion transmembrane transport | IEA | -- |
No data available for SIGNOR curated interactions for ABCC3 Gene
Drugs & Compounds for ABCC3 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Cisplatin | Approved | Pharma | Transporter, inducer | Inhibits DNA synthesis,chemotherapy drug, Platinum, Potent pro-apoptotic anticancer agent; activates caspase-3 | 2690 | |
| Doxorubicin | Approved, Investigational | Pharma | Transporter, inhibitor | Topo II inhibitor,immunosuppresive antineoplastic antibiotic | 1714 | |
| Methotrexate | Approved | Pharma | Transporter, substrate, inhibitor | Folate antagonist,inhibits DFHR | 1518 | |
| Vincristine | Approved, Investigational | Pharma | Transporter, inhibitor | Microtubule disrupter,antitumor agent | 904 | |
| Etoposide | Approved | Pharma | Transporter, substrate, inhibitor | Topo II inhibitor, Topoisomerase 2 Inhibitors, Topoisomerase II inhibitor | 1232 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| (3a,5b,7a)-23-Carboxy-7-hydroxy-24-norcholan-3-yl-b-D-Glucopyranosiduronic acid |
|
58814-71-4 |
|
|||
| 1,3,12-Trihydroxycholan-24-oic acid |
|
63266-91-1 |
|
|||
| 1,3,7,12-Tetrahydroxycholan-24-oic acid |
|
63266-89-7 |
|
|||
| 12a-Hydroxy-3-oxocholadienic acid |
|
13535-96-1 |
|
|||
| 12b-Hydroxy-5b-cholanoic acid |
|
15173-23-6 |
|
Transcripts for ABCC3 Gene
mRNA/cDNA for ABCC3 Gene
- (11) REFSEQ mRNAs :
- (16) Additional mRNA sequences :
- (233) Selected AceView cDNA sequences:
- (18) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for ABCC3 Gene
CRISPR Products
-
OriGene CRISPR knockouts for ABCC3
- GenScript: Design CRISPR guide RNA sequences for ABCC3
miRNA Products
- Search ViGene Biosciences for ABCC3
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for ABCC3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ABCC3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16a | · | 16b | ^ | 17a | · | 17b | ^ | 18 | ^ | 19 | ^ | 20a | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP13: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP14: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP15: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP16: |
| ExUns: | 20b | ^ | 21 | ^ | 22 | ^ | 23a | · | 23b | · | 23c | · | 23d | ^ | 24a | · | 24b | · | 24c | ^ | 25 | ^ | 26a | · | 26b | · | 26c | ^ | 27 | ^ | 28a | · | 28b | ^ | 29a | · | 29b | ^ | 30 | ^ | 31a | · | 31b | ^ | 32a | · | 32b | ^ | 33a | · | 33b | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP13: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP14: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP15: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP16: |
| ExUns: | 34 | ^ | 35a | · | 35b | · | 35c | ^ | 36 | ^ | 37a | · | 37b | · | 37c | · | 37d |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||
| SP2: | - | - | - | ||||||||||||||
| SP3: | - | - | - | ||||||||||||||
| SP4: | |||||||||||||||||
| SP5: | |||||||||||||||||
| SP6: | - | - | - | ||||||||||||||
| SP7: | |||||||||||||||||
| SP8: | |||||||||||||||||
| SP9: | |||||||||||||||||
| SP10: | |||||||||||||||||
| SP11: | |||||||||||||||||
| SP12: | |||||||||||||||||
| SP13: | |||||||||||||||||
| SP14: | |||||||||||||||||
| SP15: | - | ||||||||||||||||
| SP16: |
Expression for ABCC3 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Intestine (Gastrointestinal Tract)
- Lung (Respiratory System)
-
Colon (Gastrointestinal Tract)
-
Gall Bladder (Hepatobiliary System)
-
Adrenal Gland (Endocrine System)
-
Stomach (Gastrointestinal Tract)
-
Liver (Hepatobiliary System)
-
Pancreas (Endocrine System)
mRNA differential expression in normal tissues according to GTEx for ABCC3 Gene
This gene is overexpressed in Adrenal Gland (x9.2), Liver (x7.7), Colon - Transverse (x5.6), and Pancreas (x4.2).
This gene is overexpressed in Islet of Langerhans (27.8), Pancreas (10.9), and Adrenal (6.8).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ABCC3 Gene
NURSA nuclear receptor signaling pathways regulating expression of ABCC3 Gene:
ABCC3SOURCE GeneReport for Unigene cluster for ABCC3 Gene:
Hs.463421mRNA Expression by UniProt/SwissProt for ABCC3 Gene:
O15438-MRP3_HUMAN
Tissue specificity:
Mainly expressed in the liver. Also expressed in small intestine, colon, prostate, testis, brain and at a lower level in the kidney.
Primer Products
-
OriGene qPCR primer pairs for ABCC3
No data available for Protein tissue co-expression partners for ABCC3 Gene
Orthologs for ABCC3 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ABCC3 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | ABCC3 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | ABCC3 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Abcc3 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Abcc3 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | -- 35 |
|
OneToMany | |
| -- 35 |
|
OneToMany | |||
| platypus (Ornithorhynchus anatinus) |
Mammalia | ABCC3 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | ABCC3 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | ABCC3 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | abcc3 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | ABCC3 35 |
|
OneToOne | |
| fruit fly (Drosophila melanogaster) |
Insecta | MRP 34 |
|
||
| CG6214 36 |
|
|
|||
| Sur 36 |
|
|
|||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP009835 34 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | mrp-7 36 34 |
|
||
| mrp-2 36 |
|
|
|||
| mrp-8 36 |
|
|
|||
| cft-1 35 |
|
ManyToMany | |||
| C18C4.2 36 |
|
|
|||
| A. gosspyii yeast (Ashbya gossypii) |
Saccharomycetes | AGOS_AGR047W 34 |
|
||
| K. lactis yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0F20075g 34 |
|
||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | YCF1 34 35 |
|
||
| thale cress (Arabidopsis thaliana) |
eudicotyledons | MRP10 34 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os04g0209200 34 |
|
||
| bread mold (Neurospora crassa) |
Ascomycetes | NCU09012 34 |
|
||
| fission yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | abc2 34 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
OneToMany |
- Species where no ortholog for ABCC3 was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for ABCC3 Gene
(20) SIMAP similar genes for ABCC3 Gene using alignment to 9 proteins:
Variants for ABCC3 Gene
| SNP ID | Clin | Chr 17 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1003354 | -- | 50,667,702(+) | GCGCA(A/C/G/T)GGCGG | nc-transcript-variant, reference, missense | |
| rs1003355 | -- | 50,667,705(+) | CACGG(C/G/T)GGCCT | nc-transcript-variant, reference, missense | |
| rs10153257 | -- | 50,635,862(+) | TGGGC(A/G)AAAGA | intron-variant | |
| rs1051625 | -- | 50,684,078(+) | ATGAC(C/G)TGCGC | nc-transcript-variant, reference, missense | |
| rs1051640 | -- | 50,691,125(+) | GCTGA(A/G)TTTGA | nc-transcript-variant, reference, synonymous-codon |
Residual Variation Intolerance Score:
42.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
5.81;
73.76% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for ABCC3 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ABCC3 Gene
Disorders for ABCC3 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| dubin-johnson syndrome |
|
|
| extrahepatic cholestasis |
|
|
| cholangiolocellular carcinoma |
|
|
| cholestasis |
|
|
| bile duct carcinoma |
|
|
Search ABCC3 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for ABCC3
No data available for UniProtKB/Swiss-Prot and Genatlas for ABCC3 Gene
Publications for ABCC3 Gene
- Characterization of MOAT-C and MOAT-D, new members of the MRP/cMOAT subfamily of transporter proteins. (PMID: 9827529) Belinsky M.G. … Kruh G.D. (J. Natl. Cancer Inst. 1998) 2 3 4 22 64
- Functional reconstitution of human ABCC3 into proteoliposomes reveals a transport mechanism with positive cooperativity. (PMID: 19334674) Zehnpfennig B. … Galla H.J. (Biochemistry 2009) 3 22 25 64
- Genetic variations of the ABC transporter gene ABCC3 in a Japanese population. (PMID: 17495421) Fukushima-Uesaka H. … Sawada J. (Drug Metab. Pharmacokinet. 2007) 3 22 46 64
- Transport of glyburide by placental ABC transporters: implications in fetal drug exposure. (PMID: 16460798) Gedeon C. … Piquette-Miller M. (Placenta 2006) 3 22 25 64
- Transport of bile acids in multidrug-resistance-protein 3-overexpressing cells co-transfected with the ileal Na+-dependent bile-acid transporter. (PMID: 12220224) Zelcer N. … Borst P. (Biochem. J. 2003) 3 22 25 64
Products for ABCC3 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for ABCC3
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for ABCC3
- Search Origene for MassSpec and Protein Over-expression Lysates for ABCC3
- Origene Custom Protein Services for ABCC3
- Origene shRNA, siRNA, mouse_rna, rat_shrna, and RNAi products in human, mouse, rat for ABCC3
- Browse OriGene Inhibitory RNA Products For ABCC3
- OriGene qPCR primer pairs for ABCC3
- OriGene CRISPR knockouts for ABCC3
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For ABCC3
- GenScript: Next-day shipping cDNA clones in your preferred vector
- GenScript Custom Purified and Recombinant Proteins Services for ABCC3
- GenScript Custom Assay Services for ABCC3
- GenScript Custom overexpressing Cell Line Services for ABCC3
- GenScript: Design CRISPR guide RNA sequences for ABCC3
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for ABCC3
- Cell Signaling Technology (CST) Antibodies for ABCC3 (ABCC3)
- Search for Antibodies & Assays
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Proteins
- Sino Biological Antibodies
- Sino Biological ELISA Kits and Pair Sets
- Sino Biological Cell Lysates
- Sino Biological qPCR Primers
- Sino Biological CRO Services for Proteins, Antibodies and Genes
- Sino Biological Transfection Reagents
- Novus Biologicals Antibodies for ABCC3
- Novus Biologicals proteins and lysates for ABCC3
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Cloud-Clone Corp. Antibodies for ABCC3
- Cloud-Clone Corp. Proteins for ABCC3
- Cloud-Clone Corp Assay Kits for ABCC3
- Taconic Biosciences Mouse Models for ABCC3
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- antibodies-online Antibodies for ABCC3: See all 75
- antibodies-online Kits for ABCC3: See all 13
- Search antibodies-online for proteins
- Search antibodies-online for peptides
- GeneTex ABCC3 antibody for ABCC3
- Search GeneTex for Proteins for ABCC3
- ViGene Biosciences adenoviral particle packaged cDNA for ABCC3 gene
- ViGene Biosciences lentiviral particle packaged cDNA for ABCC3 gene
- ViGene Biosciences ready-to-package AAV shRNAs for ABCC3 gene
- Search ViGene Biosciences for ABCC3
- Santa Cruz Biotechnology (SCBT) Antibodies for ABCC3
- Search Santa Cruz Biotechnology (SCBT) for ABCC3 siRNA/shRNA
- Browse Santa Cruz Biotechnology (SCBT) for ABCC3 CRISPR
- Horizon Cell Lines for ABCC3
- Cyagen custom Knockout/knockin (KOKI) mouse models for ABCC3
- VectorBuilder custom plasmid, inducible vectors for ABCC3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ABCC3
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for ABCC3 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
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- (13) InterPro
- (14) ProtoNet
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- (16) MGI
- (17) IUBMB
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- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
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- (122) diseasecard
- (123) NIH Rare Diseases
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- (133) NCBI Bookshelf
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- (135) Gene Damage Index
- (136) ViGene Biosciences
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- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab