Aliases for ABCC3 Gene
- ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 3 2 3
- CMOAT2 3 4 6
- MLP2 3 4 6
- MRP3 3 4 6
- Canalicular Multispecific Organic Anion Transporter 2 2 3
- Multi-Specific Organic Anion Transporter D 3 4
- ATP-Binding Cassette Sub-Family C Member 3 3 4
- Multidrug Resistance-Associated Protein 3 3 4
- MOAT-D 3 4
External Ids for ABCC3 Gene
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The specific function of this protein has not yet been determined; however, this protein may play a role in the transport of biliary and intestinal excretion of organic anions. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]
GeneCards Summary for ABCC3 Gene
ABCC3 (ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 3) is a Protein Coding gene. Diseases associated with ABCC3 include cholangiolocellular carcinoma and dubin-johnson syndrome. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include ATPase activity, coupled to transmembrane movement of substances and organic anion transmembrane transporter activity. An important paralog of this gene is ABCC5.
UniProtKB/Swiss-Prot for ABCC3 Gene
May act as an inducible transporter in the biliary and intestinal excretion of organic anions. Acts as an alternative route for the export of bile acids and glucuronides from cholestatic hepatocytes (By similarity).