Aliases for ABCC3 Gene
Aliases for ABCC3 Gene
- ATP Binding Cassette Subfamily C Member 3 2 3 5
- ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 3 2 3
- Canalicular Multispecific Organic Anion Transporter 2 2 3
- Multi-Specific Organic Anion Transporter D 3 4
- ATP-Binding Cassette Sub-Family C Member 3 3 4
- Multidrug Resistance-Associated Protein 3 3 4
- CMOAT2 3 4
- MOAT-D 3 4
- MLP2 3 4
External Ids for ABCC3 Gene
- HGNC: 54
- Entrez Gene: 8714
- Ensembl: ENSG00000108846
- OMIM: 604323
- UniProtKB: O15438
Previous GeneCards Identifiers for ABCC3 Gene
- GC17P048425
- GC17P051193
- GC17P049054
- GC17P049186
- GC17P046067
- GC17P048712
- GC17P044080
Summaries for ABCC3 Gene
-
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The specific function of this protein has not yet been determined; however, this protein may play a role in the transport of biliary and intestinal excretion of organic anions. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]
GeneCards Summary for ABCC3 Gene
ABCC3 (ATP Binding Cassette Subfamily C Member 3) is a Protein Coding gene. Diseases associated with ABCC3 include Dubin-Johnson Syndrome and Extrahepatic Cholestasis. Among its related pathways are Vinka Alkaloid Pathway, Pharmacokinetics and Constitutive Androstane Receptor Pathway. Gene Ontology (GO) annotations related to this gene include transporter activity and ATPase activity, coupled to transmembrane movement of substances. An important paralog of this gene is ABCC2.
UniProtKB/Swiss-Prot for ABCC3 Gene
-
May act as an inducible transporter in the biliary and intestinal excretion of organic anions. Acts as an alternative route for the export of bile acids and glucuronides from cholestatic hepatocytes (By similarity).
Additional gene information for ABCC3 Gene
- Monarch Initiative
- Search for ABCC3 at DataMed
- Search for ABCC3 at HumanCyc
No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ABCC3 Gene
Genomics for ABCC3 Gene
GeneHancer (GH) Regulatory Elements for ABCC3 Gene
- Top Transcription factor binding sites by QIAGEN in the ABCC3 gene promoter:
Regulatory Element Products
Genomic Locations for ABCC3 Gene
- chr17:50,634,777-50,692,252
- (GRCh38/hg38)
- Size:
- 57,476 bases
- Orientation:
- Plus strand
- chr17:48,712,138-48,769,613
- (GRCh37/hg19)
Genomic View for ABCC3 Gene
- Cytogenetic band:
-
- 17q21.33 by Ensembl
- 17q21.33 by Entrez Gene
- 17q21.33 by HGNC


RefSeq DNA sequence for ABCC3 Gene
Proteins for ABCC3 Gene
-
Protein details for ABCC3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O15438-MRP3_HUMAN
- Recommended name:
- Canalicular multispecific organic anion transporter 2
- Protein Accession:
- O15438
- B2RPA9
- D3DTX9
- O60265
- O60922
- O75621
- O95078
- O95289
- O95290
- Q86X85
- Q9UN52
Protein attributes for ABCC3 Gene
- Size:
- 1527 amino acids
- Molecular mass:
- 169343 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=AAB71756.1; Type=Frameshift; Positions=1334, 1338; Evidence={ECO:0000305}; Sequence=AAD01430.1; Type=Frameshift; Positions=355, 359, 361; Evidence={ECO:0000305}; Sequence=AAD38185.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};
Protein Expression for ABCC3 Gene
Selected DME Specific Peptides for ABCC3 Gene
- O15438:
-
- SVGQRQL
- GEIRIDG
- LSGGQRQRV
- ASTVGEI
Post-translational modifications for ABCC3 Gene
- Glycosylation at Asn18, posLast=10061006, and posLast=10071007
Other Protein References for ABCC3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Cell Signaling Technology (CST) Antibodies for ABCC3 (ABCC3)
-
Custom Antibody ServicesOriGene Antibodies for ABCC3
- Novus Biologicals Antibodies for ABCC3
-
Abcam antibodies for ABCC3
-
Cloud-Clone Corp. Antibodies for ABCC3
- Invitrogen Antibodies for ABCC3
- GeneTex ABCC3 antibody for ABCC3
-
Santa Cruz Biotechnology (SCBT) Antibodies for ABCC3
Protein Products
-
OriGene Purified Proteins for ABCC3
- Search Origene for MassSpec and Protein Over-expression Lysates for ABCC3
- Origene Custom Protein Services for ABCC3
-
Cloud-Clone Corp. Proteins for ABCC3
- Search GeneTex for Proteins for ABCC3
Assay Products
-
Cloud-Clone Corp. Assay Kits for ABCC3
Domains & Families for ABCC3 Gene
Gene Families for ABCC3 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Predicted intracellular proteins
- Predicted membrane proteins
- Transporters
Protein Domains for ABCC3 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for ABCC3 Gene
Graphical View of Domain Structure for InterPro Entry
O15438UniProtKB/Swiss-Prot:
MRP3_HUMAN :- Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
- Family:
-
- Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
Function for ABCC3 Gene
Molecular function for ABCC3 Gene
- GENATLAS Biochemistry:
- ATP binding cassette superfamily,subfamily C (CFTR/MRP),member 3,expressed in liver,colon,small intestine and prostate,involved in the adrenal glands,biliary and intestinal excretion of organic anions
- UniProtKB/Swiss-Prot Function:
- May act as an inducible transporter in the biliary and intestinal excretion of organic anions. Acts as an alternative route for the export of bile acids and glucuronides from cholestatic hepatocytes (By similarity).
Enzyme Numbers (IUBMB) for ABCC3 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005215 | transporter activity | IEA | -- |
GO:0005524 | ATP binding | IEA | -- |
GO:0008514 | organic anion transmembrane transporter activity | TAS | 9738950 |
GO:0008559 | xenobiotic transmembrane transporting ATPase activity | IBA | -- |
GO:0015432 | bile acid-exporting ATPase activity | TAS | -- |
Phenotypes for ABCC3 Gene
- MGI mutant phenotypes for ABCC3:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for ABCC3:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for ABCC3
-
-
ViGene Biosciences lentiviral particle packaged cDNA for ABCC3 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for ABCC3 gene
- Search ViGene Biosciences for ABCC3
CRISPR Products
-
OriGene CRISPR knockouts for ABCC3
- genomics-online: gRNA clones - Search results for 89 available MRP gene related products
- Overview of 89 available MRP gene related products
- Applied Biological Materials CRISPR for ABCC3
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ABCC3
- GenScript: Design CRISPR guide RNA sequences for ABCC3
miRNA for ABCC3 Gene
- miRTarBase miRNAs that target ABCC3
miRNA Products
- Search ViGene Biosciences for ABCC3
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for ABCC3
- Browse OriGene Inhibitory RNA Products For ABCC3
- genomics-online: shRNA clones - Search results for 89 available MRP gene related products
- Overview of 89 available MRP gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for ABCC3 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for ABCC3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ABCC3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for ABCC3
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for ABCC3
-
ViGene Biosciences adenoviral particle packaged cDNA for ABCC3 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for ABCC3 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for ABCC3 gene
No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ABCC3 Gene
Localization for ABCC3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ABCC3 Gene
- Membrane; Multi-pass membrane protein.
- Plasma membrane (2)
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005886 | plasma membrane | TAS | -- |
GO:0005887 | integral component of plasma membrane | IBA,TAS | -- |
GO:0016020 | membrane | IEA,TAS | 9813153 |
GO:0016021 | integral component of membrane | IEA | -- |
GO:0016323 | basolateral plasma membrane | IBA | -- |
Pathways & Interactions for ABCC3 Gene
Pathways by source for ABCC3 Gene
1 Cell Signaling Technology pathway for ABCC3 Gene
7 BioSystems pathways for ABCC3 Gene
6 Reactome pathways for ABCC3 Gene
8 PharmGKB pathways for ABCC3 Gene
3 KEGG pathways for ABCC3 Gene
2 R&D Systems pathways for ABCC3 Gene
Interacting Proteins for ABCC3 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006810 | transport | TAS | 9813153 |
GO:0006855 | drug transmembrane transport | IBA | -- |
GO:0015721 | bile acid and bile salt transport | TAS | -- |
GO:0015722 | canalicular bile acid transport | ISS | -- |
GO:0042908 | xenobiotic transport | IBA | -- |
No data available for SIGNOR curated interactions for ABCC3 Gene
Drugs & Compounds for ABCC3 Gene
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Cisplatin | Approved | Pharma | Transporter, inducer | Inhibits DNA synthesis,chemotherapy drug, Potent pro-apoptotic anticancer agent; activates caspase-3, Platinum | 2906 | |
Doxorubicin | Approved, Investigational | Pharma | Transporter, inhibitor | Topo II inhibitor,immunosuppresive antineoplastic antibiotic | 1828 | |
Methotrexate | Approved | Pharma | Transporter, substrate, inhibitor | Folate antagonist,inhibits DFHR | 1603 | |
Vincristine | Approved, Investigational | Pharma | Transporter, inhibitor | Microtubule disrupter,antitumor agent | 965 | |
Etoposide | Approved | Pharma | Transporter, substrate, inhibitor | Topo II inhibitor, Topoisomerase 2 Inhibitors | 1302 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
(3a,5b,7a)-23-Carboxy-7-hydroxy-24-norcholan-3-yl-b-D-Glucopyranosiduronic acid |
|
58814-71-4 |
|
|||
1,3,12-Trihydroxycholan-24-oic acid |
|
63266-91-1 |
|
|||
1,3,7,12-Tetrahydroxycholan-24-oic acid |
|
63266-89-7 |
|
|||
12a-Hydroxy-3-oxocholadienic acid |
|
13535-96-1 |
|
|||
12b-Hydroxy-5b-cholanoic acid |
|
15173-23-6 |
|
Transcripts for ABCC3 Gene
mRNA/cDNA for ABCC3 Gene
- (11) REFSEQ mRNAs :
- (16) Additional mRNA sequences :
- (233) Selected AceView cDNA sequences:
- (18) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for ABCC3 Gene
CRISPR Products
-
OriGene CRISPR knockouts for ABCC3
- genomics-online: gRNA clones - Search results for 89 available MRP gene related products
- Overview of 89 available MRP gene related products
- Applied Biological Materials CRISPR for ABCC3
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ABCC3
- GenScript: Design CRISPR guide RNA sequences for ABCC3
miRNA Products
- Search ViGene Biosciences for ABCC3
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for ABCC3
- Browse OriGene Inhibitory RNA Products For ABCC3
- genomics-online: shRNA clones - Search results for 89 available MRP gene related products
- Overview of 89 available MRP gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for ABCC3 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for ABCC3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ABCC3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for ABCC3
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16a | · | 16b | ^ | 17a | · | 17b | ^ | 18 | ^ | 19 | ^ | 20a | · |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
SP3: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
SP4: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
SP5: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP6: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP7: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP8: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP9: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP10: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP11: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP12: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP13: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP14: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP15: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP16: |
ExUns: | 20b | ^ | 21 | ^ | 22 | ^ | 23a | · | 23b | · | 23c | · | 23d | ^ | 24a | · | 24b | · | 24c | ^ | 25 | ^ | 26a | · | 26b | · | 26c | ^ | 27 | ^ | 28a | · | 28b | ^ | 29a | · | 29b | ^ | 30 | ^ | 31a | · | 31b | ^ | 32a | · | 32b | ^ | 33a | · | 33b | ^ |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
SP3: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
SP4: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP5: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP6: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP7: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP8: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP9: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP10: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP11: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP12: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP13: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP14: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP15: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP16: |
ExUns: | 34 | ^ | 35a | · | 35b | · | 35c | ^ | 36 | ^ | 37a | · | 37b | · | 37c | · | 37d |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | ||||||||||||||
SP2: | - | - | - | ||||||||||||||
SP3: | - | - | - | ||||||||||||||
SP4: | |||||||||||||||||
SP5: | |||||||||||||||||
SP6: | - | - | - | ||||||||||||||
SP7: | |||||||||||||||||
SP8: | |||||||||||||||||
SP9: | |||||||||||||||||
SP10: | |||||||||||||||||
SP11: | |||||||||||||||||
SP12: | |||||||||||||||||
SP13: | |||||||||||||||||
SP14: | |||||||||||||||||
SP15: | - | ||||||||||||||||
SP16: |
Expression for ABCC3 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Intestine (Gastrointestinal Tract)
- Lung (Respiratory System)
-
Colon (Gastrointestinal Tract)
-
Gall Bladder (Hepatobiliary System)
-
Adrenal Gland (Endocrine System)
-
Stomach (Gastrointestinal Tract)
-
Liver (Hepatobiliary System)
-
Pancreas (Endocrine System)
mRNA differential expression in normal tissues according to GTEx for ABCC3 Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ABCC3 Gene
NURSA nuclear receptor signaling pathways regulating expression of ABCC3 Gene:
ABCC3SOURCE GeneReport for Unigene cluster for ABCC3 Gene:
Hs.463421mRNA Expression by UniProt/SwissProt for ABCC3 Gene:
O15438-MRP3_HUMANEvidence on tissue expression from TISSUES for ABCC3 Gene
- Liver(4.7)
- Blood(4.5)
- Intestine(3.5)
- Kidney(2.3)
- Gall bladder(2.2)
- Lung(2)
Primer Products
-
OriGene qPCR primer pairs for ABCC3
- genomics-online: primer clones - Search results for 89 available MRP gene related products
- Overview of 89 available MRP gene related products
No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ABCC3 Gene
Orthologs for ABCC3 Gene
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | ABCC3 34 33 |
|
OneToOne | |
dog (Canis familiaris) |
Mammalia | ABCC3 34 33 |
|
OneToOne | |
cow (Bos Taurus) |
Mammalia | ABCC3 33 34 |
|
||
mouse (Mus musculus) |
Mammalia | Abcc3 16 34 33 |
|
||
rat (Rattus norvegicus) |
Mammalia | Abcc3 33 |
|
||
oppossum (Monodelphis domestica) |
Mammalia | -- 34 |
|
OneToMany | |
-- 34 |
|
OneToMany | |||
platypus (Ornithorhynchus anatinus) |
Mammalia | ABCC3 34 |
|
OneToOne | |
chicken (Gallus gallus) |
Aves | ABCC3 34 33 |
|
OneToOne | |
lizard (Anolis carolinensis) |
Reptilia | ABCC3 34 |
|
OneToOne | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | abcc3 33 |
|
||
zebrafish (Danio rerio) |
Actinopterygii | ABCC3 34 |
|
OneToOne | |
fruit fly (Drosophila melanogaster) |
Insecta | MRP 33 |
|
||
CG6214 35 |
|
|
|||
Sur 35 |
|
|
|||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP009835 33 |
|
||
worm (Caenorhabditis elegans) |
Secernentea | mrp-7 35 33 |
|
||
mrp-2 35 |
|
|
|||
mrp-8 35 |
|
|
|||
cft-1 34 |
|
ManyToMany | |||
C18C4.2 35 |
|
|
|||
A. gosspyii yeast (Ashbya gossypii) |
Saccharomycetes | AGOS_AGR047W 33 |
|
||
K. lactis yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0F20075g 33 |
|
||
baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | YCF1 33 34 |
|
||
thale cress (Arabidopsis thaliana) |
eudicotyledons | MRP10 33 |
|
||
rice (Oryza sativa) |
Liliopsida | Os04g0209200 33 |
|
||
bread mold (Neurospora crassa) |
Ascomycetes | NCU09012 33 |
|
||
fission yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | abc2 33 |
|
||
sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany |
- Species where no ortholog for ABCC3 was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for ABCC3 Gene
(20) SIMAP similar genes for ABCC3 Gene using alignment to 9 proteins:
Variants for ABCC3 Gene
SNP ID | Clin | Chr 17 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1000017617 | -- | 50,669,867(+) | G/A | genic_downstream_transcript_variant, intron_variant | |
rs1000035374 | -- | 50,634,916(+) | T/C | 5_prime_UTR_variant, genic_upstream_transcript_variant, non_coding_transcript_variant | |
rs1000088582 | -- | 50,661,968(+) | A/G | intron_variant | |
rs1000164889 | -- | 50,653,358(+) | A/G | genic_upstream_transcript_variant, intron_variant | |
rs1000192556 | -- | 50,643,864(+) | C/T | genic_upstream_transcript_variant, intron_variant |
Additional Variant Information for ABCC3 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ABCC3 Gene
Disorders for ABCC3 Gene
Disorder | Aliases | PubMed IDs |
---|---|---|
dubin-johnson syndrome |
|
|
extrahepatic cholestasis |
|
|
cholangiolocellular carcinoma |
|
|
cholestasis |
|
|
bile duct carcinoma |
|
|
Additional Disease Information for ABCC3
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for ABCC3 Gene
Publications for ABCC3 Gene
- Characterization of MOAT-C and MOAT-D, new members of the MRP/cMOAT subfamily of transporter proteins. (PMID: 9827529) Belinsky MG … Kruh GD (Journal of the National Cancer Institute 1998) 2 3 4 22 58
- Functional reconstitution of human ABCC3 into proteoliposomes reveals a transport mechanism with positive cooperativity. (PMID: 19334674) Zehnpfennig B … Galla HJ (Biochemistry 2009) 3 22 25 58
- Genetic variations of the ABC transporter gene ABCC3 in a Japanese population. (PMID: 17495421) Fukushima-Uesaka H … Sawada J (Drug metabolism and pharmacokinetics 2007) 3 22 44 58
- Transport of glyburide by placental ABC transporters: implications in fetal drug exposure. (PMID: 16460798) Gedeon C … Piquette-Miller M (Placenta 2006) 3 22 25 58
- Transport of bile acids in multidrug-resistance-protein 3-overexpressing cells co-transfected with the ileal Na+-dependent bile-acid transporter. (PMID: 12220224) Zelcer N … Borst P (The Biochemical journal 2003) 3 22 25 58
Products for ABCC3 Gene
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- Custom Antibody ServicesOriGene Antibodies for ABCC3
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- Cloud-Clone Corp. Antibodies for ABCC3
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- Invitrogen Antibodies for ABCC3
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- Mammalian expression: PiggyBac
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- antibodies-online: Search results for 82 available MRP Antibodies ranked by validation data
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- antibodies-online: Search results for 20 available MRP Elisa Kits ranked by validation data
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- GeneTex ABCC3 antibody for ABCC3
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- Santa Cruz Biotechnology (SCBT) Antibodies for ABCC3
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- genomics-online: cdna clones - Search results for 89 available MRP gene related products
- Overview of 89 available MRP gene related products
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- Overview of 89 available MRP gene related products
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- Overview of 89 available MRP gene related products
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- Overview of 89 available MRP gene related products
- genomics-online: shRNA clones - Search results for 89 available MRP gene related products
- Overview of 89 available MRP gene related products