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Aliases for ABCC3 Gene

Aliases for ABCC3 Gene

  • ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 3 2 3
  • CMOAT2 3 4 6
  • MLP2 3 4 6
  • MRP3 3 4 6
  • Canalicular Multispecific Organic Anion Transporter 2 2 3
  • Multi-Specific Organic Anion Transporter D 3 4
  • ATP-Binding Cassette Sub-Family C Member 3 3 4
  • Multidrug Resistance-Associated Protein 3 3 4
  • MOAT-D 3 4
  • Canicular Multispecific Organic Anion Transporter 3
  • Multidrug Resistance Associated Protein 3
  • EC 3.6.3.44 63
  • EC 6.3.2.4 63
  • EST90757 3
  • EC 3.6.3 63
  • ABC31 3

External Ids for ABCC3 Gene

Previous GeneCards Identifiers for ABCC3 Gene

  • GC17P048425
  • GC17P051193
  • GC17P049054
  • GC17P049186
  • GC17P046067
  • GC17P048712
  • GC17P044080

Summaries for ABCC3 Gene

Entrez Gene Summary for ABCC3 Gene

  • The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The specific function of this protein has not yet been determined; however, this protein may play a role in the transport of biliary and intestinal excretion of organic anions. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]

GeneCards Summary for ABCC3 Gene

ABCC3 (ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 3) is a Protein Coding gene. Diseases associated with ABCC3 include cholangiolocellular carcinoma and dubin-johnson syndrome. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include ATPase activity, coupled to transmembrane movement of substances and organic anion transmembrane transporter activity. An important paralog of this gene is ABCC5.

UniProtKB/Swiss-Prot for ABCC3 Gene

  • May act as an inducible transporter in the biliary and intestinal excretion of organic anions. Acts as an alternative route for the export of bile acids and glucuronides from cholestatic hepatocytes (By similarity).

Gene Wiki entry for ABCC3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ABCC3 Gene

Genomics for ABCC3 Gene

Regulatory Elements for ABCC3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ABCC3 Gene

Start:
50,634,777 bp from pter
End:
50,692,252 bp from pter
Size:
57,476 bases
Orientation:
Plus strand

Genomic View for ABCC3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ABCC3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ABCC3 Gene

Proteins for ABCC3 Gene

  • Protein details for ABCC3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15438-MRP3_HUMAN
    Recommended name:
    Canalicular multispecific organic anion transporter 2
    Protein Accession:
    O15438
    Secondary Accessions:
    • B2RPA9
    • D3DTX9
    • O60265
    • O60922
    • O75621
    • O95078
    • O95289
    • O95290
    • Q86X85
    • Q9UN52

    Protein attributes for ABCC3 Gene

    Size:
    1527 amino acids
    Molecular mass:
    169343 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAB71756.1; Type=Frameshift; Positions=1334, 1338; Evidence={ECO:0000305}; Sequence=AAD01430.1; Type=Frameshift; Positions=355, 359, 361; Evidence={ECO:0000305}; Sequence=AAD38185.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};

    Alternative splice isoforms for ABCC3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ABCC3 Gene

Proteomics data for ABCC3 Gene at MOPED

Selected DME Specific Peptides for ABCC3 Gene

Post-translational modifications for ABCC3 Gene

  • Glycosylation at Asn18, Asn1006, and Asn1007
  • Modification sites at PhosphoSitePlus

Other Protein References for ABCC3 Gene

Domains for ABCC3 Gene

Gene Families for ABCC3 Gene

HGNC:
  • ABCC :ATP binding cassette transporters / subfamily C
IUPHAR :

Graphical View of Domain Structure for InterPro Entry

O15438

UniProtKB/Swiss-Prot:

MRP3_HUMAN :
  • O15438
Domain:
  • Contains 2 ABC transmembrane type-1 domains.
  • Contains 2 ABC transporter domains.
Family:
  • Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
genes like me logo Genes that share domains with ABCC3: view

Function for ABCC3 Gene

Molecular function for ABCC3 Gene

GENATLAS Biochemistry: ATP binding cassette superfamily,subfamily C (CFTR/MRP),member 3,expressed in liver,colon,small intestine and prostate,involved in the adrenal glands,biliary and intestinal excretion of organic anions
UniProtKB/Swiss-Prot Function: May act as an inducible transporter in the biliary and intestinal excretion of organic anions. Acts as an alternative route for the export of bile acids and glucuronides from cholestatic hepatocytes (By similarity).

Enzyme Numbers (IUBMB) for ABCC3 Gene

Gene Ontology (GO) - Molecular Function for ABCC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity --
GO:0005524 ATP binding IEA --
GO:0008514 organic anion transmembrane transporter activity TAS 9738950
GO:0016887 ATPase activity --
GO:0042626 ATPase activity, coupled to transmembrane movement of substances IEA --
genes like me logo Genes that share ontologies with ABCC3: view
genes like me logo Genes that share phenotypes with ABCC3: view

Animal Models for ABCC3 Gene

MGI Knock Outs for ABCC3:

Animal Model Products

CRISPR Products

miRNA for ABCC3 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ABCC3

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targeting and HOMER Transcription for ABCC3 Gene

Localization for ABCC3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ABCC3 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ABCC3 Gene COMPARTMENTS Subcellular localization image for ABCC3 gene
Compartment Confidence
plasma membrane 4
nucleus 2
vacuole 2
cytoskeleton 1
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for ABCC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IEA --
GO:0016020 membrane TAS 9813153
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with ABCC3: view

Pathways for ABCC3 Gene

genes like me logo Genes that share pathways with ABCC3: view

PCR Array Products

Interacting Proteins for ABCC3 Gene

Gene Ontology (GO) - Biological Process for ABCC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006200 obsolete ATP catabolic process --
GO:0006810 transport TAS 9813153
GO:0008206 bile acid metabolic process TAS --
GO:0015721 bile acid and bile salt transport TAS --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with ABCC3: view

Compounds for ABCC3 Gene

(85) HMDB Compounds for ABCC3 Gene

Compound Synonyms Cas Number PubMed IDs
(3a,5b,7a)-23-Carboxy-7-hydroxy-24-norcholan-3-yl-b-D-Glucopyranosiduronic acid
  • Chenodeoxycholic acid 3-glucuronide
58814-71-4
1,3,12-Trihydroxycholan-24-oic acid
  • 1,3,12-Trihydroxycholan-24-oate
63266-91-1
1,3,7,12-Tetrahydroxycholan-24-oic acid
  • 1,3,7,12-Tetrahydroxycholan-24-oate
63266-89-7
12a-Hydroxy-3-oxocholadienic acid
  • 12a-Hydroxy-3-oxo-4,6-choladien-24-oate
13535-96-1
12b-Hydroxy-5b-cholanoic acid
  • 12b-Hydroxy-5b-cholanic acid
15173-23-6

(27) Drugbank Compounds for ABCC3 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Cholic Acid
81-25-4 transporter inhibitor
Cisplatin
  • CDDP
15663-27-1 transporter inducer
Clotrimazole
  • Chlotrimazole
23593-75-1 transporter inducer
Conjugated Estrogens
  • Estrogens
438-67-5 transporter inhibitor
Cyclosporine
  • Ciclosporin
59865-13-3 transporter inhibitor

(45) Novoseek inferred chemical compound relationships for ABCC3 Gene

Compound -log(P) Hits PubMed IDs
estradiol-17beta-glucuronide 89.7 4
etoposide glucuronide 87.6 6
taurocholate 71.7 7
5-carboxyfluorescein 68.1 2
androstane 68 1

(5) PharmGKB related drug/compound annotations for ABCC3 Gene

Drug/compound Annotation
cisplatin CA
cyclophosphamide CA
doxorubicin CA
methotrexate CA
vincristine CA
genes like me logo Genes that share compounds with ABCC3: view

Transcripts for ABCC3 Gene

Unigene Clusters for ABCC3 Gene

ATP-binding cassette, sub-family C (CFTR/MRP), member 3:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ABCC3

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for ABCC3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ABCC3 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17a · 17b ^ 18 ^ 19 ^ 20a ·
SP1: - - - - -
SP2: - - - -
SP3: - - - - -
SP4: - - - - -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10: -
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:

ExUns: 20b ^ 21 ^ 22 ^ 23a · 23b · 23c · 23d ^ 24a · 24b · 24c ^ 25 ^ 26a · 26b · 26c ^ 27 ^ 28a · 28b ^ 29a · 29b ^ 30 ^ 31a · 31b ^ 32a · 32b ^ 33a · 33b ^
SP1: - - - -
SP2: - - - -
SP3: - - - -
SP4:
SP5: -
SP6: - -
SP7:
SP8:
SP9: -
SP10:
SP11:
SP12: - -
SP13:
SP14:
SP15:
SP16:

ExUns: 34 ^ 35a · 35b · 35c ^ 36 ^ 37a · 37b · 37c · 37d
SP1: - - -
SP2: - - -
SP3: - - -
SP4:
SP5:
SP6: - - -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15: -
SP16:

Relevant External Links for ABCC3 Gene

GeneLoc Exon Structure for
ABCC3
ECgene alternative splicing isoforms for
ABCC3

Expression for ABCC3 Gene

mRNA expression in normal human tissues for ABCC3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ABCC3 Gene

This gene is overexpressed in Adrenal Gland (9.2), Liver (7.7), Colon - Transverse (5.6), and Pancreas (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ABCC3 Gene

SOURCE GeneReport for Unigene cluster for ABCC3 Gene Hs.463421

mRNA Expression by UniProt/SwissProt for ABCC3 Gene

O15438-MRP3_HUMAN
Tissue specificity: Mainly expressed in the liver. Also expressed in small intestine, colon, prostate, testis, brain and at a lower level in the kidney
genes like me logo Genes that share expressions with ABCC3: view

In Situ Assay Products

Orthologs for ABCC3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ABCC3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ABCC3 35
  • 94.78 (n)
  • 93.89 (a)
ABCC3 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ABCC3 35
  • 85.92 (n)
  • 84.94 (a)
ABCC3 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ABCC3 35
  • 86.33 (n)
  • 84.82 (a)
ABCC3 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Abcc3 35
  • 82.45 (n)
  • 81.07 (a)
Abcc3 16
Abcc3 36
  • 81 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 77 (a)
OneToMany
-- 36
  • 70 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia ABCC3 36
  • 61 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Abcc3 35
  • 81.65 (n)
  • 79.63 (a)
chicken
(Gallus gallus)
Aves ABCC3 35
  • 67.8 (n)
  • 69.87 (a)
ABCC3 36
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ABCC3 36
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia abcc3 35
  • 64.87 (n)
  • 67.76 (a)
zebrafish
(Danio rerio)
Actinopterygii ABCC3 36
  • 62 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009835 35
  • 53.5 (n)
  • 46.44 (a)
fruit fly
(Drosophila melanogaster)
Insecta MRP 35
  • 57.2 (n)
  • 51.44 (a)
Sur 37
  • 45 (a)
CG6214 37
  • 47 (a)
worm
(Caenorhabditis elegans)
Secernentea cft-1 36
  • 24 (a)
ManyToMany
mrp-7 35
  • 49.48 (n)
  • 46.13 (a)
mrp-7 37
  • 38 (a)
mrp-8 37
  • 42 (a)
mrp-2 37
  • 45 (a)
C18C4.2 37
  • 23 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR047W 35
  • 48.26 (n)
  • 42.68 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YCF1 35
  • 46.78 (n)
  • 42.48 (a)
YCF1 36
  • 39 (a)
OneToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F20075g 35
  • 47.8 (n)
  • 44.03 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons MRP10 35
  • 45.58 (n)
  • 36.03 (a)
rice
(Oryza sativa)
Liliopsida Os04g0209200 35
  • 48.35 (n)
  • 38.15 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU09012 35
  • 51.85 (n)
  • 42.49 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes abc2 35
  • 46.4 (n)
  • 42.36 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 34 (a)
OneToMany
Species with no ortholog for ABCC3:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ABCC3 Gene

ENSEMBL:
Gene Tree for ABCC3 (if available)
TreeFam:
Gene Tree for ABCC3 (if available)

Paralogs for ABCC3 Gene

Paralogs for ABCC3 Gene

genes like me logo Genes that share paralogs with ABCC3: view

Variants for ABCC3 Gene

Sequence variations from dbSNP and Humsavar for ABCC3 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs719717 -- 50,652,137(-) TGAAA(C/G)AGCTC intron-variant
rs732760 -- 50,638,458(-) AAGCA(C/G)TCACT intron-variant
rs733392 -- 50,659,042(+) GGTAG(A/G)AACTT intron-variant
rs733393 -- 50,658,928(+) AAATT(C/G)CCCAG intron-variant
rs739921 -- 50,642,229(-) AAACA(C/G)GTCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ABCC3 Gene

Variant ID Type Subtype PubMed ID
nsv833477 CNV Loss 17160897
dgv3230n71 CNV Loss 21882294
dgv42n68 CNV Loss 17160897
nsv2083 CNV Insertion 18451855
nsv908609 CNV Gain 21882294
esv2716038 CNV Deletion 23290073

Relevant External Links for ABCC3 Gene

HapMap Linkage Disequilibrium report
ABCC3
Human Gene Mutation Database (HGMD)
ABCC3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ABCC3 Gene

Disorders for ABCC3 Gene

(4) University of Copenhagen DISEASES for ABCC3 Gene

(28) Novoseek inferred disease relationships for ABCC3 Gene

Disease -log(P) Hits PubMed IDs
dubin-johnson syndrome 71.4 1
cholestasis 68.3 7
cholestasis extrahepatic 57.3 3
breast cancer 41.7 20
hepatocellular carcinoma 38 8

Relevant External Links for ABCC3

Genetic Association Database (GAD)
ABCC3
Human Genome Epidemiology (HuGE) Navigator
ABCC3
genes like me logo Genes that share disorders with ABCC3: view

No data available for UniProtKB/Swiss-Prot for ABCC3 Gene

Publications for ABCC3 Gene

  1. Characterization of MOAT-C and MOAT-D, new members of the MRP/cMOAT subfamily of transporter proteins. (PMID: 9827529) Belinsky M.G. … Kruh G.D. (J. Natl. Cancer Inst. 1998) 2 3 4 23
  2. cDNA cloning and inducible expression of human multidrug resistance associated protein 3 (MRP3). (PMID: 9738950) Kiuchi Y. … Sugiyama Y. (FEBS Lett. 1998) 3 4 23 25
  3. Characterization of the human multidrug resistance protein isoform MRP3 localized to the basolateral hepatocyte membrane. (PMID: 10094960) Koenig J. … Keppler D. (Hepatology 1999) 3 4 23
  4. Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines. (PMID: 9270026) Kool M. … Borst P. (Cancer Res. 1997) 3 4 23
  5. Genetic variations of the ABC transporter gene ABCC3 in a Japanese population. (PMID: 17495421) Fukushima-Uesaka H. … Sawada J. (Drug Metab. Pharmacokinet. 2007) 3 23 48

Products for ABCC3 Gene

Sources for ABCC3 Gene

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