Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ABCC2 Gene

protein-coding   GIFtS: 68
GCID: GC10P101532

ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 2

(Previous name: canalicular multispecific organic anion transporter 1)
(Previous symbol: CMOAT)
Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 21 2     ATP-Binding Cassette Sub-Family C Member 22 3
CMOAT1 2 3 5     ABC302
Canalicular Multispecific Organic Anion Transporter 11 2     DJS2
Canalicular Multidrug Resistance Protein2 3     cMRP2
Multidrug Resistance-Associated Protein 22 3     CMOAT13
MRP22 3     CMRP3

External Ids:    HGNC: 531   Entrez Gene: 12442   Ensembl: ENSG000000238397   OMIM: 6011075   UniProtKB: Q928873   

Export aliases for ABCC2 gene to outside databases

Previous GC identifers: GC10P100435 GC10P100776 GC10P101673 GC10P101207 GC10P095169


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ABCC2 Gene:
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC
proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven
distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily
which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the
hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine;
therefore, this protein appears to contribute to drug resistance in mammalian cells. Several different mutations
in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder
characterized by conjugated hyperbilirubinemia. (provided by RefSeq, Jul 2008)

GeneCards Summary for ABCC2 Gene: 
ABCC2 (ATP-binding cassette, sub-family C (CFTR/MRP), member 2) is a protein-coding gene. Diseases associated with ABCC2 include dubin-johnson syndrome, and rotor syndrome, and among its related super-pathways are Irinotecan Pathway, Pharmacokinetics and Codeine and Morphine Pathway, Pharmacokinetics. GO annotations related to this gene include ATPase activity, coupled to transmembrane movement of substances and organic anion transmembrane transporter activity. An important paralog of this gene is ABCC4.

UniProtKB/Swiss-Prot: MRP2_HUMAN, Q92887
Function: Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin
transporter

Gene Wiki entry for ABCC2 (Multidrug resistance-associated protein 2) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NT_030059.13  NC_018921.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ABCC2 gene promoter:
         HFH-3   Sox5   GATA-3   FOXD3   GATA-2   FOXL1   FOXI1   FOXC1   FOXJ2 (long isoform)   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ABCC2 promoter sequence
   Search SABiosciences Chromatin IP Primers for ABCC2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ABCC2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q24   Ensembl cytogenetic band:  10q24.2   HGNC cytogenetic band: 10q24

ABCC2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ABCC2 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P101532:  view genomic region     (about GC identifiers)

Start:
101,542,463 bp from pter      End:
101,611,949 bp from pter
Size:
69,487 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MRP2_HUMAN, Q92887 (See protein sequence)
Recommended Name: Canalicular multispecific organic anion transporter 1  
Size: 1545 amino acids; 174207 Da
Subcellular location: Membrane; Multi-pass membrane protein
Secondary accessions: B2RMT8 Q14022 Q5T2B1 Q92500 Q92798 Q99663 Q9UMS2

Explore the universe of human proteins at neXtProt for ABCC2: NX_Q92887

Explore proteomics data for ABCC2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q92887

  • ABCC2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ABCC2 Protein Expression
    REFSEQ proteins: NP_000383.1  
    ENSEMBL proteins: 
     ENSP00000359478   ENSP00000359463  
    Reactome Protein details: Q92887
    Human Recombinant Protein Products for ABCC2: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for ABCC2
    GenScript Custom Purified and Recombinant Proteins Services for ABCC2
    Novus Biologicals ABCC2 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ABCC2 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane IEA--
    GO:0016020membrane ----
    GO:0016021integral to membrane ----
    GO:0016324apical plasma membrane ISS--

    ABCC2 for ontologies           About GeneDecksing



    ABCC2 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of ABCC2
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for ABCC2 
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for ABCC2
    GenScript Custom Superior Antibodies Services for ABCC2
    Novus Biologicals ABCC2 Antibodies
    Abcam antibodies for ABCC2
    Cloud-Clone Corp. Antibodies for ABCC2 
    ThermoFisher Antibodies for ABCC2
    LSBio Antibodies in human, mouse, rat for ABCC2 

    Assay Products for ABCC2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ABCC2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ABCC2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ABCC2 
    Cloud-Clone Corp. CLIAs for ABCC2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ABCC: ATP binding cassette transporters / subfamily C

    IUPHAR Guide to PHARMACOLOGY protein family classification: ABCC2 
    ABCC subfamily

    5/8 InterPro protein domains (see all 8):
     IPR003439 ABC_transporter-like
     IPR027417 P-loop_NTPase
     IPR001140 ABC_transptr_TM_dom
     IPR003593 AAA+_ATPase
     IPR017940 ABC_transporter_type1

    Graphical View of Domain Structure for InterPro Entry Q92887

    ProtoNet protein and cluster: Q92887

    UniProtKB/Swiss-Prot: MRP2_HUMAN, Q92887
    Similarity: Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208)
    subfamily
    Similarity: Contains 2 ABC transmembrane type-1 domains
    Similarity: Contains 2 ABC transporter domains


    ABCC2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MRP2_HUMAN, Q92887
    Function: Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin
    transporter

         Genatlas biochemistry entry for ABCC2:
    ATP binding cassette superfamily,subfamily C (CFTR/MRP),member 2,mainly expressed in canilicular membranes of
    hepatocytes,also present in other apical domains of prolonged cells,such as the epithelial cells of proximal
    tubule of kidney

         Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding ----
    GO:0005215transporter activity ----
    GO:0005515protein binding IPI--
    GO:0005524ATP binding IEA--
    GO:0008514organic anion transmembrane transporter activity TAS7559771
         
    ABCC2 for ontologies           About GeneDecksing


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Abcc2):
     hematopoietic system  homeostasis/metabolism  liver/biliary system  renal/urinary system 

    ABCC2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Abcc2tm1Ahs for ABCC2

       inGenious Targeting Laboratory - Custom generated mouse model solutions for ABCC2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ABCC2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ABCC2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ABCC2 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ABCC2
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate ABCC2
    SwitchGear 3'UTR luciferase reporter plasmidABCC2 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ABCC2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ABCC2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ABCC2
    Sirion Biotech Customized adenovirus for overexpression of ABCC2

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for ABCC2 (see all 5)
    OriGene ORF clones in mouse, rat for ABCC2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ABCC2 (NM_000392)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ABCC2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ABCC2

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ABCC2
    Search LifeMap BioReagents cell lines for ABCC2
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ABCC2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ABCC2 About   (see all 17)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Irinotecan Pathway, Pharmacokinetics
    Irinotecan Pathway, Pharmacokinetics0.69
    Irinotecan Pathway, Pharmacodynamics0.50
    Irinotecan Pathway0.69
    Taxane Pathway, Pharmacokinetics0.30
    Mycophenolic acid Pathway, Pharmacokinetics/Pharmacodynamics0.50
    2Codeine and morphine metabolism
    Codeine and morphine metabolism0.89
    Tramadol Pharmacokinetics0.36
    Codeine and Morphine Pathway, Pharmacokinetics0.89
    3ABC-family proteins mediated transport
    ABC-family proteins mediated transport0.70
    ABC transporters0.70
    4Atorvastatin/Lovastatin/Simvastatin Pathway, Pharmacokinetics
    Atorvastatin/Lovastatin/Simvastatin Pathway, Pharmacokinetics0.80
    Ibuprofen Pathway, Pharmacokinetics0.50
    Statin Pathway - Generalized, Pharmacokinetics0.70
    5Pravastatin Pathway, Pharmacokinetics
    Pravastatin Pathway, Pharmacokinetics0.47
    Methotrexate Pathway, Pharmacokinetics0.47

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for ABCC2
        Hepatic ABC Transporters

    1 Cell Signaling Technology (CST) Pathway for ABCC2
        Glucose / Energy Metabolism

    4 BioSystems Pathways for ABCC2
        Codeine and morphine metabolism
    Irinotecan Pathway
    Nuclear receptors in lipid metabolism and toxicity
    Drug Induction of Bile Acid Pathway

    2        Reactome Pathways for ABCC2
        ABC-family proteins mediated transport
    Transmembrane transport of small molecules

    5/18 PharmGKB Pathways for ABCC2 (see all 18)
        Atorvastatin/Lovastatin/Simvastatin Pathway, Pharmacokinetics
    Carbamazepine Pathway, Pharmacokinetics
    Codeine and Morphine Pathway, Pharmacokinetics
    Doxorubicin Pathway (Cancer Cell), Pharmacodynamics
    Doxorubicin Pathway, Pharmacokinetics

    2         Kegg Pathways  (Kegg details for ABCC2):
        ABC transporters
    Bile secretion


    ABCC2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ABCC2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    5/13 Interacting proteins for ABCC2 (Q928871, 3 ENSP000003594784) via UniProtKB, MINT, STRING, and/or I2D (see all 13)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RDXP352413, ENSP000003428304I2D: score=2 STRING: ENSP00000342830
    SLC9A3R1O147453, ENSP000002626134I2D: score=2 STRING: ENSP00000262613
    PDZK1Q5T2W13, ENSP000003421434I2D: score=2 STRING: ENSP00000342143
    CANXP278243, ENSP000002474614I2D: score=1 STRING: ENSP00000247461
    PDZD3Q86UT53, ENSP000003271074I2D: score=1 STRING: ENSP00000327107
    About this table

    Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport TAS7559771
    GO:0006855drug transmembrane transport IEA--
    GO:0006979response to oxidative stress IEA--
    GO:0009408response to heat IEA--
    GO:0015732prostaglandin transport IEA--

    ABCC2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ABCC2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Enzo Life Sciences drugs & compounds for ABCC2

    Browse Tocris compounds for ABCC2 (MRP2)

    2 HMDB Compounds for ABCC2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Bilirubin(4Z,15Z)-Bilirubin IXa (see all 17)635-65-417517076
    Pravastatin3beta-Hydroxycompactin (see all 7)81093-37-0--

    10/76 DrugBank Compounds for ABCC2 (see all 76)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    SulfinpyrazoneDiphenylpyrazone (see all 6)57-96-5targetinhibitor11834888 17229912 10727523 11108662 10917554 11500505
    transportersubstrate inhibitor11834888 17229912 10727523 11108662 10917554 11500505 11834888 10917554
    Probenecid-- 57-66-9transportersubstrate inhibitor15618649 12608533 14511674 10727523 11880368 12538836 19319690
    CyclosporineCiclosporin (see all 4)59865-13-3transporterinhibitor10570049 15618649 12134946 14511674 10421658
    Glutathione5-L-Glutamyl-L-cysteinylglycine (see all 5)70-18-8transportersubstrate inhibitor10024515 10692506 10648470 10491184 1430236
    MethotrexateAmethopterin (see all 12)59-05-2transportersubstrate inhibitor9270020 12608533 10727523 11465411 10363967
    PhenobarbitalFenobarbital (see all 7)50-06-6transporterinducer11861969 11841808 11323161 9571149 11706036
    Vinblastine-- 865-21-4transportersubstrate inhibitor inducer12134946 15616150 11323161 17045309 2172249
    IndomethacinIMN (see all 9)53-86-1transportersubstrate inhibitor19541926 10870987 16460798 19319690
    Pravastatin-- 81093-37-0transportersubstrate inhibitor11748225 15616150 9321514 15901800
    SaquinavirSaquinavir Mesylate (see all 2)127779-20-8transportersubstrate15504753 12384350 12702717 12441801

    10/146 Novoseek inferred chemical compound relationships for ABCC2 gene (see all 146)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mk 571 90.7 12 17855498 (1), 18405608 (1), 18718123 (1), 19201990 (1) (see all 10)
    oatp 86.7 15 17724432 (3), 20501720 (1), 19620935 (1), 18838068 (1) (see all 6)
    gf 120918 85.6 6 19491037 (1), 18515333 (1), 16244858 (1)
    estradiol-17beta-glucuronide 83.7 10 18180270 (2), 11748225 (1), 18761402 (1), 20071452 (1) (see all 5)
    probenecid 79.5 32 15849751 (5), 15618649 (2), 15904671 (1), 18267365 (1) (see all 14)
    androstane 79 10 11706036 (2), 15382119 (1), 20048746 (1), 19661216 (1) (see all 7)
    psc-833 78.8 6 16356829 (1), 17543436 (1), 18195111 (1), 18515333 (1)
    bilirubin monoglucuronide 78.5 7 11897625 (1), 19566819 (1), 9355767 (1), 19214140 (1) (see all 5)
    s-(2,4-dinitrophenyl)glutathione 78.1 2 9794924 (1), 9525973 (1)
    sulfinpyrazone 74.4 9 18180270 (2), 10917554 (1), 14569069 (1), 11500505 (1)

    6 PharmGKB related drug/compound annotations for ABCC2 gene    About this table
    Drug/compound PharmGKB Annotation
    antiepilepticsCA  
    carbamazepineCA  
    doxorubicinCA  
    erythromycinCA  
    talinololCA  
    tenofovirCA  

    Search CenterWatch for drugs/clinical trials and news about ABCC2 / MRP2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ABCC2 gene: 
    NM_000392.3  

    Unigene Cluster for ABCC2:

    ATP-binding cassette, sub-family C (CFTR/MRP), member 2
    Hs.368243  [show with all ESTs]
    Unigene Representative Sequence: U49248
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000370449(uc001kqf.2) ENST00000370434 ENST00000496621

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ABCC2
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate ABCC2
    SwitchGear 3'UTR luciferase reporter plasmidABCC2 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ABCC2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ABCC2
    Clone
    Products:
         
    OriGene clones in human, mouse for ABCC2 (see all 5)
    OriGene ORF clones in mouse, rat for ABCC2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ABCC2 (NM_000392)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ABCC2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ABCC2
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for ABCC2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ABCC2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ABCC2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ABCC2

    Additional mRNA sequence: 

    BC136419.1 U49248.1 U63970.1 X96395.2 

    8 DOTS entries:

    DT.216029  DT.99999029  DT.121300501  DT.121300494  DT.216028  DT.100731911  DT.121300498  DT.92046395 

    24/76 AceView cDNA sequences (see all 76):

    AA699522 AV656541 AV660932 BX643341 BQ220800 BM765259 BF589901 CA429833 
    BX495933 AI566147 R02136 U49248 AV660925 CB155960 AV652973 AA706096 
    AA931070 BM804774 NM_000392 BP359602 AA187829 BX116034 AI522182 AI823554 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ABCC2 expression in normal human tissues (normalized intensities)      ABCC2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AACCTACTAC
    ABCC2 Expression
    About this image


    ABCC2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/7 selected tissues (see all 7) fully expand
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
     
     Intestine (Gastrointestinal Tract)
             small intestine   
     
     Adipose (Muscoskeletal System)
             Human Preadipocyte-visceral (HPA-v)   
     
     Kidney (Urinary System)
             kidney ; cells in tubules   
     
     Gall Bladder (Hepatobiliary System)
             gallbladder ; glandular cells   

    See ABCC2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ABCC2

    SOURCE GeneReport for Unigene cluster: Hs.368243

    UniProtKB/Swiss-Prot: MRP2_HUMAN, Q92887
    Tissue specificity: Found on the apical membrane of polarized cells in liver, kidney and intestine. The highest
    expression is found in liver

        SABiosciences Expression via Pathway-Focused PCR Arrays including ABCC2: 
              Nephrotoxicity in human mouse rat
              Drug Transporters in human mouse rat
              Cancer Drug Resistance in human mouse rat
              Hepatotoxicity in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for ABCC2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ABCC2
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ABCC2
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ABCC2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ABCC2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ABCC2 gene from 8/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Abcc21 , 5 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 less1, 5 80.91(n)1
    77.76(a)1
      19 (36.67 cM)5
    127801  NM_013806.21  NP_038834.21 
     437821925 
    chicken
    (Gallus gallus)
    Aves ABCC21 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 less 65.6(n)
    63.91(a)
      423828  XM_421698.3  XP_421698.3 
    lizard
    (Anolis carolinensis)
    Reptilia ABCC26
    Uncharacterized protein
    64(a)
    1 ↔ 1
    3(38272079-38308779)
    zebrafish
    (Danio rerio)
    Actinopterygii zgc660722 similar to multidrug resistance protein 2 73.77(n)   393561  BC056740.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Sur3 heart development sulfonylurea receptor 46(a)
    (best of 2)
      31B1   --
    worm
    (Caenorhabditis elegans)
    Secernentea mrp-23 ATP-binding transport family 41(a)
    (best of 3)
      X(599137-607953)   --
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons MRP11 ABC transporter C family member 1 50.01(n)
    42.47(a)
      839920  NM_001036039.1  NP_001031116.1 
    rice
    (Oryza sativa)
    Liliopsida AK120122.12   -- 73.92(n)    AK120122.1 


    ENSEMBL Gene Tree for ABCC2 (if available)
    TreeFam Gene Tree for ABCC2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ABCC2 gene
    ABCC42  ABCC122  ABCC102  ABCC12  CFTR2  ABCC82  ABCC52  ABCC32  
    ABCC112  ABCC92  
    18/20 SIMAP similar genes for ABCC2 using alignment to 2 protein entries:     MRP2_HUMAN (see all proteins) (see all similar genes):
    TAP1    DKFZp434I2115    DKFZp781G125    NG-TRA    ABCB4    MRP3
    CFTR    ABCC3    MOAT-B    ABCC1    ABCC4    ABCC6
    MRP    ABCC11    ABCC12    ABCC9    ABCC10    ara

    ABCC2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for ABCC2
    PGOHUM00000258120


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1756 SNPs in ABCC2 are shown (see all 1756)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0133274
    Dubin-Johnson syndrome (DJS)4--see VAR_0133272 R H mis40--------
    VAR_0133284
    Dubin-Johnson syndrome (DJS)4--see VAR_0133282 I F mis40--------
    VAR_0107564
    Dubin-Johnson syndrome (DJS)4--see VAR_0107562 Q R mis40--------
    rs561995351,2,4
    C,FDubin-Johnson syndrome (DJS)4 pathogenic1101578577(+) AGCAGC/G/TGGATC 2 R W mis15MN WA EA CSA 841
    rs725582001,2
    Cpathogenic1101595882(+) GAGGCA/GTCTGG 2 H R mis10--------
    rs725582011,2
    Cpathogenic1101595950(+) CAGTTA/TTCCGT 2 I F mis10--------
    rs725582021,2
    Cpathogenic1101605538(+) CCCCCA/GGGTGA 2 Q R mis10--------
    VAR_0471524
    ----see VAR_0471522 Y F mis40--------
    rs1872301511,2
    --101540642(+) AAAGGC/TGCACC 1 -- us2k10--------
    rs1488374201,2
    --101540647(+) TGCACA/CCTGCC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ABCC2 (101542463 - 101611949 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for ABCC2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv825539CNV Loss20364138
    nsv895918CNV Loss21882294
    dgv805n71CNV Loss21882294
    nsv895921CNV Loss21882294
    nsv895917CNV Loss21882294
    nsv831960CNV Gain17160897
    nsv825540CNV Gain20364138


    Human Gene Mutation Database (HGMD): ABCC2
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing ABCC2
    DNA2.0 Custom Variant and Variant Library Synthesis for ABCC2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 601107   
    OMIM disorders: 237500  
    UniProtKB/Swiss-Prot: MRP2_HUMAN, Q92887
  • Dubin-Johnson syndrome (DJS) [MIM:237500]: Autosomal recessive disorder characterized by conjugated
    hyperbilirubinemia, an increase in the urinary excretion of coproporphyrin isomer I, deposition of melanin-like
    pigment in hepatocytes, and prolonged retention of sulfobromophthalein, but otherwise normal liver function.
    Note=The disease is caused by mutations affecting the gene represented in this entry

  • 20/76 diseases for ABCC2 (see all 76):    About MalaCards
    dubin-johnson syndrome    rotor syndrome    cholestasis    intrahepatic cholestasis of pregnancy
    dysembryoplastic neuroepithelial tumor    intrahepatic cholestasis    cholangitis    factor vii deficiency
    hepatocellular adenoma    central nervous system lymphoma    hepatoblastoma    obstructive jaundice
    sclerosing cholangitis    malignant mesothelioma    primary sclerosing cholangitis    biliary atresia
    leukopenia    primary biliary cirrhosis    jaundice    nasopharyngitis

    3 diseases from the University of Copenhagen DISEASES database for ABCC2:
    Bilirubin metabolic disorder     Cholestasis     Cancer

    ABCC2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/57 Novoseek inferred disease relationships for ABCC2 gene (see all 57)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    dubin-johnson syndrome 95.3 83 11477083 (3), 10464142 (3), 19881259 (2), 15777714 (2) (see all 42)
    hyperbilirubinemia 74.5 41 15965653 (4), 19881259 (2), 15870973 (2), 12884082 (2) (see all 20)
    cholestasis 71.3 31 18700187 (3), 2035335 (3), 11481619 (2), 15057744 (2) (see all 17)
    cholestasis intrahepatic 63.8 3 17997497 (2), 19882051 (1)
    rotor syndrome 59.4 1 7483689 (1)
    breast cancer 56.9 95 18845662 (2), 20071452 (2), 20441926 (2), 15180326 (1) (see all 56)
    ovarian carcinoma 46.6 22 10767994 (5), 10537344 (4), 15262134 (3), 12216079 (2) (see all 9)
    colon adenocarcinoma 42.9 2 15896333 (1), 17430634 (1)
    cancer 40 46 10427140 (3), 9398612 (3), 8797578 (1), 9270026 (1) (see all 32)
    liver diseases 36.5 22 17725603 (4), 18926681 (2), 9185779 (1), 10319416 (1) (see all 8)

    Genetic Association Database (GAD): ABCC2
    Human Genome Epidemiology (HuGE) Navigator: ABCC2 (89 documents)

    Export disorders for ABCC2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ABCC2 gene, integrated from 9 sources (see all 812):
    (articles sorted by number of sources associating them with ABCC2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mutation of Trp1254 in the multispecific organic anion transporter, multidrug resistance protein 2 (MRP2) (ABCC2), alters substrate specificity and results in loss of methotrexate transport activity. (PubMed id 11500505)1, 2, 7, 9 Ito K....Cole S.P.C. (2001)
    2. Non-response to antiepileptic pharmacotherapy is associated with the ABCC2 -24C>T polymorphism in young and adult patients with epilepsy. (PubMed id 19415824)1, 4, 7, 9 Ufer M....Cascorbi I. (2009)
    3. High-dose methotrexate in pediatric acute lymphoblastic leukemia: impact of ABCC2 polymorphisms on plasma concentrations. (PubMed id 17112803)1, 4, 7, 9 Rau T....Langer T. (2006)
    4. Association between ABCC2 gene haplotypes and tenofovir-induced proximal tubulopathy. (PubMed id 17083032)1, 4, 7, 9 Izzedine H....Deray A.G. (2006)
    5. A human canalicular multispecific organic anion transporter (cMOAT) gene is overexpressed in cisplatin-resistant human cancer cell lines with decreased drug accumulation. (PubMed id 8797578)1, 2, 3, 9 Taniguchi K.... Kuwano M. (1996)
    6. Integrated pharmacogenetic prediction of irinotecan pharmacokinetics and toxicity in patients with advanced non-small cell lung cancer. (PubMed id 18221820)1, 4, 7 Han J.Y....Lee J.S. (2008)
    7. Identification and functional analysis of two novel mutations in the multidrug resistance protein 2 gene in Israeli patients with Dubin- Johnson syndrome. (PubMed id 11477083)1, 2, 9 Mor-Cohen R....Seligsohn U. (2001)
    8. Multidrug resistance-related protein 2 genotype of the donor affects kidney graft function. (PubMed id 19214140)1, 4, 9 Grisk O....Rettig R. (2009)
    9. Exon-intron organization of the human multidrug-resistance protein 2 (MRP2) gene mutated in Dubin-Johnson syndrome. (PubMed id 10464142)1, 2, 9 Tsujii H.... Keppler D. (1999)
    10. MRP2 haplotypes confer differential susceptibility to toxic liver injury. (PubMed id 17502832)1, 4, 9 Choi J.H....Lee M.G. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1244 HGNC: 53 AceView: ABCC2 Ensembl:ENSG00000023839 euGenes: HUgn1244
    ECgene: ABCC2 Kegg: 1244 H-InvDB: ABCC2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ABCC2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ABCC2 Genetics and Cytogenetics in Oncology and Haematology
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/ABCC2
    ABCMdbhttp://abcmutations.hegelab.org/proteinDetails?uniprot_id=Q92887

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ABCC2 gene:
    Search GeneIP for patents involving ABCC2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of ABCC2
     Browse Small Molecules at EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for ABCC2  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for ABCC2  
     OriGene qSTAR qPCR primer pairs in human, mouse for ABCC2   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for ABCC2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ABCC2   OriGene Custom Protein Services for ABCC2  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ABCC2
     QIAGEN SeqTarget long-range PCR primers for resequencing ABCC2
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ABCC2
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ABCC2
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ABCC2
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ABCC2
     GenScript Custom Purified and Recombinant Proteins Services for ABCC2 GenScript cDNA clones with any tag delivered in your preferred vector for ABCC2
     GenScript Custom Assay Services for ABCC2 GenScript Custom Superior Antibodies Services for ABCC2
     GenScript Custom overexpressing Cell Line Services for ABCC2 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Antibodies & Assays for ABCC2 

     Regulatory tfbs in ABCC2 promoter
     Search Chromatin IP Primers for ABCC2
     RT2 qPCR Primer Assay in human, mouse, rat ABCC2
     GNC Network for ABCC2
     SABiosciences PCR Arrays including human, mouse, rat ABCC2
     Search Tocris compounds for ABCC2 (MRP2)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Drugs for ABCC2
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     ABCC2 antibodies
     ABCC2 proteins
     Antibodies for ABCC2
     See all of Abcam's Antibodies, Kits and Proteins for ABCC2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for ABCC2
     Antibodies for ABCC2
     ELISAs for ABCC2
     CLIAs for ABCC2
     Search LifeMap BioReagents cell lines for ABCC2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ABCC2
     SwitchGear 3'UTR luciferase reporter plasmids for ABCC2
     SwitchGear Promoter luciferase reporter plasmids for ABCC2
     ThermoFisher Antibodies for ABCC2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ABCC2
     inGenious Targeting Laboratory - Custom generated mouse model solutions for ABCC2
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ABCC2
    Customized:
     lentivirus for stable overexpression
     lentivirus expression plasmids for stable overexpression
     adenovirus for overexpression of ABCC2
     LSBio Antibodies in human, mouse, rat for ABCC2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      ABCC2 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4