Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ABCC2 Gene

Aliases for ABCC2 Gene

  • ATP Binding Cassette Subfamily C Member 2 2 3 5
  • ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 2 2 3
  • Canalicular Multispecific Organic Anion Transporter 1 2 3
  • Multidrug Resistance-Associated Protein 2 3 4
  • Canalicular Multidrug Resistance Protein 3 4
  • CMOAT 3 4
  • CMRP 3 4
  • MRP2 3 4
  • ATP-Binding Cassette Sub-Family C Member 2 4
  • CMOAT1 4
  • ABC30 3
  • DJS 3

External Ids for ABCC2 Gene

Previous HGNC Symbols for ABCC2 Gene

  • CMOAT

Previous GeneCards Identifiers for ABCC2 Gene

  • GC10P100435
  • GC10P100776
  • GC10P101673
  • GC10P101207
  • GC10P101532
  • GC10P095169

Summaries for ABCC2 Gene

Entrez Gene Summary for ABCC2 Gene

  • The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine; therefore, this protein appears to contribute to drug resistance in mammalian cells. Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia. [provided by RefSeq, Jul 2008]

GeneCards Summary for ABCC2 Gene

ABCC2 (ATP Binding Cassette Subfamily C Member 2) is a Protein Coding gene. Diseases associated with ABCC2 include Dubin-Johnson Syndrome and Abcc2-Related Altered Drug Metabolism. Among its related pathways are Nuclear Receptors in Lipid Metabolism and Toxicity and Hepatic ABC Transporters. GO annotations related to this gene include transporter activity and protein domain specific binding. An important paralog of this gene is ABCC1.

UniProtKB/Swiss-Prot for ABCC2 Gene

  • Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporter.

Gene Wiki entry for ABCC2 Gene

Additional gene information for ABCC2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ABCC2 Gene

Genomics for ABCC2 Gene

Regulatory Elements for ABCC2 Gene

Enhancers for ABCC2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10H099845 1.2 Ensembl ENCODE 11.2 +63.4 63425 1 PKNOX1 ATF1 RB1 KLF17 ZBTB40 BATF DNMT3B ZNF2 ZSCAN9 RAD21 DNMBP-AS1 NANOGP6 ABCC2 DNMBP EBAG9P1 GC10P099874
GH10H099617 1.4 ENCODE dbSUPER 8.4 -162.7 -162664 5 HDGF PKNOX1 FOXA2 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B CWF19L1 CHUK PHBP9 EBAG9P1 TPM4P1 SPCS2P2 ENSG00000231188 ENSG00000236308 DNMBP SLC25A28
GH10H099944 1.1 Ensembl ENCODE dbSUPER 10 +162.5 162475 2 RFX1 JUND ATF3 JUN HNF4G FOS HNF4A DNMBP NANOGP6 ABCC2 DNMBP-AS1
GH10H099658 1.3 ENCODE dbSUPER 7.5 -121.5 -121515 5 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 FOS SP3 CWF19L1 SLC25A28 CUTC CHUK EBAG9P1 ENTPD7 ABCC2 PIR56896
GH10H099684 1.2 Ensembl ENCODE dbSUPER 6.7 -97.0 -96994 1 SMARCE1 PKNOX1 ETV1 ELF1 DPF2 JUND SMARCA4 EED IKZF1 HMBOX1 EBAG9P1 ABCC2 PIR56896
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ABCC2 on UCSC Golden Path with GeneCards custom track

Genomic Location for ABCC2 Gene

Chromosome:
10
Start:
99,782,598 bp from pter
End:
99,852,576 bp from pter
Size:
69,979 bases
Orientation:
Plus strand

Genomic View for ABCC2 Gene

Genes around ABCC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ABCC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ABCC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ABCC2 Gene

Proteins for ABCC2 Gene

  • Protein details for ABCC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92887-MRP2_HUMAN
    Recommended name:
    Canalicular multispecific organic anion transporter 1
    Protein Accession:
    Q92887
    Secondary Accessions:
    • B2RMT8
    • Q14022
    • Q5T2B1
    • Q92500
    • Q92798
    • Q99663
    • Q9UMS2

    Protein attributes for ABCC2 Gene

    Size:
    1545 amino acids
    Molecular mass:
    174207 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ABCC2 Gene

Post-translational modifications for ABCC2 Gene

  • Glycosylation at posLast=77, Asn12, and Asn1011
  • Modification sites at PhosphoSitePlus

Other Protein References for ABCC2 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for ABCC2 (ABCC2)
  • Abcam antibodies for ABCC2

No data available for DME Specific Peptides for ABCC2 Gene

Domains & Families for ABCC2 Gene

Gene Families for ABCC2 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • FDA approved drug targets
  • Plasma proteins
  • Predicted membrane proteins
  • Transporters

Suggested Antigen Peptide Sequences for ABCC2 Gene

Graphical View of Domain Structure for InterPro Entry

Q92887

UniProtKB/Swiss-Prot:

MRP2_HUMAN :
  • Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
Family:
  • Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
genes like me logo Genes that share domains with ABCC2: view

Function for ABCC2 Gene

Molecular function for ABCC2 Gene

GENATLAS Biochemistry:
ATP binding cassette superfamily,subfamily C (CFTR/MRP),member 2,mainly expressed in canilicular membranes of hepatocytes,also present in other apical domains of prolonged cells,such as the epithelial cells of proximal tubule of kidney
UniProtKB/Swiss-Prot Function:
Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporter.

Gene Ontology (GO) - Molecular Function for ABCC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity IEA --
GO:0005515 protein binding IPI 17825285
GO:0005524 ATP binding IEA --
GO:0008514 organic anion transmembrane transporter activity IEA,TAS 7559771
GO:0015127 bilirubin transmembrane transporter activity TAS --
genes like me logo Genes that share ontologies with ABCC2: view
genes like me logo Genes that share phenotypes with ABCC2: view

Human Phenotype Ontology for ABCC2 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for ABCC2 Gene

MGI Knock Outs for ABCC2:

Animal Model Products

  • Taconic Biosciences Mouse Models for ABCC2

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ABCC2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , miRNA , Transcription Factor Targets and HOMER Transcription for ABCC2 Gene

Localization for ABCC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ABCC2 Gene

Apical cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ABCC2 gene
Compartment Confidence
plasma membrane 5
nucleus 2
extracellular 1
cytoskeleton 1
endoplasmic reticulum 1
cytosol 1

Gene Ontology (GO) - Cellular Components for ABCC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA,IEA --
GO:0009986 cell surface IDA 17825285
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ABCC2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ABCC2 Gene

Pathways & Interactions for ABCC2 Gene

genes like me logo Genes that share pathways with ABCC2: view

Gene Ontology (GO) - Biological Process for ABCC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport TAS 7559771
GO:0006855 drug transmembrane transport IEA --
GO:0006979 response to oxidative stress IEA --
GO:0007565 female pregnancy IEA --
GO:0009408 response to heat IEA --
genes like me logo Genes that share ontologies with ABCC2: view

No data available for SIGNOR curated interactions for ABCC2 Gene

Drugs & Compounds for ABCC2 Gene

(169) Drugs for ABCC2 Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, FDA Approved Drugs, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Docetaxel Approved May 1996, Investigational Pharma Transporter, substrate Microtubulin disassembly inhibitor, Tubulin and VEGF inhibitor, Taxanes, Microtubule stabilizer 1993
Methotrexate Approved Pharma Transporter, substrate, inhibitor Folate antagonist,inhibits DFHR 1576
Pravastatin Approved Pharma Competitive, Inhibitor, Transporter, substrate, inhibitor 153
Ritonavir Approved, Investigational Pharma Transporter, substrate, inducer HIV protease inhibitor 888
Sulfinpyrazone Approved Pharma modulator, Target, Transporter, inhibitor, substrate 0

(51) Additional Compounds for ABCC2 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
3',4'-Dihydrodiol
O-Desmethylverapamil (D-702)

(4) ApexBio Compounds for ABCC2 Gene

Compound Action Cas Number
CP 100356 hydrochloride 142715-48-8
Fumitremorgin C 118974-02-0
KS 176 1253452-78-6
Vinblastine sulfate Anti-mitotic agent 143-67-9
genes like me logo Genes that share compounds with ABCC2: view

Drug Products

Transcripts for ABCC2 Gene

Unigene Clusters for ABCC2 Gene

ATP-binding cassette, sub-family C (CFTR/MRP), member 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ABCC2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for ABCC2 Gene

No ASD Table

Relevant External Links for ABCC2 Gene

GeneLoc Exon Structure for
ABCC2
ECgene alternative splicing isoforms for
ABCC2

Expression for ABCC2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ABCC2 Gene

mRNA differential expression in normal tissues according to GTEx for ABCC2 Gene

This gene is overexpressed in Liver (x33.3) and Kidney - Cortex (x4.4).

Protein differential expression in normal tissues from HIPED for ABCC2 Gene

This gene is overexpressed in Oral epithelium (25.5), Liver (17.0), and Plasma (14.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ABCC2 Gene



Protein tissue co-expression partners for ABCC2 Gene

NURSA nuclear receptor signaling pathways regulating expression of ABCC2 Gene:

ABCC2

SOURCE GeneReport for Unigene cluster for ABCC2 Gene:

Hs.368243

mRNA Expression by UniProt/SwissProt for ABCC2 Gene:

Q92887-MRP2_HUMAN
Tissue specificity: Expressed by polarized cells in liver, kidney and intestine. The highest expression is found in liver.

Evidence on tissue expression from TISSUES for ABCC2 Gene

  • Liver(4.8)
  • Intestine(3.1)
  • Kidney(3)
  • Blood(2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for ABCC2 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • digestive
  • integumentary
  • nervous
  • urinary
Organs:
Head and neck:
  • eye
  • head
  • mouth
Abdomen:
  • biliary tract
  • gallbladder
  • kidney
  • liver
  • pancreas
  • stomach
General:
  • skin
genes like me logo Genes that share expression patterns with ABCC2: view

Primer Products

Orthologs for ABCC2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ABCC2 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia ABCC2 33
  • 86.86 (n)
MRP2 34
  • 83 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ABCC2 33 34
  • 86.09 (n)
rat
(Rattus norvegicus)
Mammalia Abcc2 33
  • 81.16 (n)
mouse
(Mus musculus)
Mammalia Abcc2 33 16 34
  • 80.9 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ABCC2 34
  • 66 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ABCC2 34
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves ABCC2 33 34
  • 65.47 (n)
lizard
(Anolis carolinensis)
Reptilia ABCC2 34
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia abcc2 33
  • 64.17 (n)
zebrafish
(Danio rerio)
Actinopterygii abcc2 33 34
  • 60.73 (n)
zgc66072 33
fruit fly
(Drosophila melanogaster)
Insecta Sur 35
  • 46 (a)
MRP 34
  • 45 (a)
ManyToMany
CG6214 35
  • 43 (a)
worm
(Caenorhabditis elegans)
Secernentea mrp-2 35
  • 41 (a)
mrp-8 35
  • 40 (a)
mrp-3 34
  • 37 (a)
ManyToMany
mrp-7 35
  • 34 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YCF1 34
  • 37 (a)
OneToMany
NFT1 36
thale cress
(Arabidopsis thaliana)
eudicotyledons MRP1 33
  • 50.33 (n)
wheat
(Triticum aestivum)
Liliopsida Ta.9148 33
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 46 (a)
ManyToMany
Species where no ortholog for ABCC2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for ABCC2 Gene

ENSEMBL:
Gene Tree for ABCC2 (if available)
TreeFam:
Gene Tree for ABCC2 (if available)

Paralogs for ABCC2 Gene

Paralogs for ABCC2 Gene

(20) SIMAP similar genes for ABCC2 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for ABCC2 Gene

genes like me logo Genes that share paralogs with ABCC2: view

Variants for ABCC2 Gene

Sequence variations from dbSNP and Humsavar for ABCC2 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs56199535 Pathogenic, Dubin-Johnson syndrome (DJS) [MIM:237500] 99,818,820(+) AGCAG(A/C/G/T)GGATC nc-transcript-variant, reference, missense
rs72558200 Pathogenic, Dubin-Johnson syndrome (DJS) [MIM:237500] 99,836,125(+) GAGGC(A/G)TCTGG nc-transcript-variant, reference, missense
rs72558201 Pathogenic, Dubin-Johnson syndrome (DJS) [MIM:237500] 99,836,193(+) CAGTT(A/G/T)TCCGT nc-transcript-variant, reference, missense
rs72558202 Pathogenic, Dubin-Johnson syndrome (DJS) [MIM:237500] 99,845,781(+) CCCCC(A/G)GGTGA nc-transcript-variant, reference, missense
rs146405172 Pathogenic 99,811,603(+) CGAGA(A/G)TGAGT splice-donor-variant

Structural Variations from Database of Genomic Variants (DGV) for ABCC2 Gene

Variant ID Type Subtype PubMed ID
dgv506n106 CNV deletion 24896259
esv3423829 CNV duplication 20981092
nsv1046030 CNV loss 25217958
nsv1137953 CNV deletion 24896259
nsv825539 CNV loss 20364138
nsv825540 CNV gain 20364138
nsv831960 CNV gain 17160897

Variation tolerance for ABCC2 Gene

Residual Variation Intolerance Score: 86.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.72; 78.70% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ABCC2 Gene

Human Gene Mutation Database (HGMD)
ABCC2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ABCC2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ABCC2 Gene

Disorders for ABCC2 Gene

MalaCards: The human disease database

(13) MalaCards diseases for ABCC2 Gene - From: HGMD, OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
dubin-johnson syndrome
  • chronic idiopathic jaundice
abcc2-related altered drug metabolism
  • multidrug resistance associated protein 2
bilirubin metabolic disorder
  • hereditary hyperbilirubinemia
intrahepatic cholestasis
  • intrahepatic cholestasis of pregnancy
cholestasis
  • bile occlusion
- elite association - COSMIC cancer census association via MalaCards
Search ABCC2 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

MRP2_HUMAN
  • Dubin-Johnson syndrome (DJS) [MIM:237500]: Autosomal recessive disorder characterized by conjugated hyperbilirubinemia, an increase in the urinary excretion of coproporphyrin isomer I, deposition of melanin-like pigment in hepatocytes, and prolonged retention of sulfobromophthalein, but otherwise normal liver function. {ECO:0000269 PubMed:10053008, ECO:0000269 PubMed:10464142, ECO:0000269 PubMed:11093739, ECO:0000269 PubMed:11266082, ECO:0000269 PubMed:11477083, ECO:0000269 PubMed:22290738, ECO:0000269 PubMed:25336012, ECO:0000269 PubMed:9425227}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for ABCC2

Genetic Association Database (GAD)
ABCC2
Human Genome Epidemiology (HuGE) Navigator
ABCC2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ABCC2
genes like me logo Genes that share disorders with ABCC2: view

No data available for Genatlas for ABCC2 Gene

Publications for ABCC2 Gene

  1. Mutation of Trp1254 in the multispecific organic anion transporter, multidrug resistance protein 2 (MRP2) (ABCC2), alters substrate specificity and results in loss of methotrexate transport activity. (PMID: 11500505) Ito K … Cole SP (The Journal of biological chemistry 2001) 3 4 22 25 60
  2. A human canalicular multispecific organic anion transporter (cMOAT) gene is overexpressed in cisplatin-resistant human cancer cell lines with decreased drug accumulation. (PMID: 8797578) Taniguchi K … Kuwano M (Cancer research 1996) 2 3 4 22 60
  3. A nonsynonymous variation in MRP2/ABCC2 is associated with neurological adverse drug reactions of carbamazepine in patients with epilepsy. (PMID: 20216337) Kim WJ … Lee MG (Pharmacogenetics and genomics 2010) 3 22 45 60
  4. Telmisartan pharmacokinetics in Japanese renal transplant recipients. (PMID: 18838068) Miura M … Suzuki T (Clinica chimica acta; international journal of clinical chemistry 2009) 3 22 45 60
  5. Multidrug resistance-related protein 2 genotype of the donor affects kidney graft function. (PMID: 19214140) Grisk O … Rettig R (Pharmacogenetics and genomics 2009) 3 22 45 60

Products for ABCC2 Gene

Sources for ABCC2 Gene

Content
Loading form....