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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ABCC2 Gene

protein-coding GIFtS: 68
GCID: GC10P101532

ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 2

(Previous name: canalicular multispecific organic anion transporter 1)
(Previous symbol: CMOAT)

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 2¹ ²		ATP-Binding Cassette Sub-Family C Member 2² ³
CMOAT¹ ² ³ ⁵		ABC30²
Canalicular Multispecific Organic Anion Transporter 1¹ ²		DJS²
Canalicular Multidrug Resistance Protein² ³		cMRP²
Multidrug Resistance-Associated Protein 2² ³		CMOAT1³
MRP2² ³		CMRP³

External Ids:	HGNC: 53¹	Entrez Gene: 1244²	Ensembl: ENSG00000023839⁷	OMIM: 601107⁵	UniProtKB: Q92887³

Export aliases for ABCC2 gene to outside databases

Previous GC identifers: GC10P100435 GC10P100776 GC10P101673 GC10P101207 GC10P095169

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ABCC2 Gene:

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC

proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven

distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily

which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the

hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine;

therefore, this protein appears to contribute to drug resistance in mammalian cells. Several different mutations

in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder

characterized by conjugated hyperbilirubinemia. (provided by RefSeq, Jul 2008)

GeneCards Summary for ABCC2 Gene:

ABCC2 (ATP-binding cassette, sub-family C (CFTR/MRP), member 2) is a protein-coding gene. Diseases associated with ABCC2 include dubin-johnson syndrome, and rotor syndrome, and among its related super-pathways are Irinotecan Pathway, Pharmacokinetics and Codeine and Morphine Pathway, Pharmacokinetics. GO annotations related to this gene include ATPase activity, coupled to transmembrane movement of substances and organic anion transmembrane transporter activity. An important paralog of this gene is ABCC4.

UniProtKB/Swiss-Prot: MRP2_HUMAN, Q92887

Function: Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin

transporter

Gene Wiki entry for ABCC2 (Multidrug resistance-associated protein 2) Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000010.10 NT_030059.13 NC_018921.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ABCC2 gene promoter:
HFH-3 Sox5 GATA-3 FOXD3 GATA-2 FOXL1 FOXI1 FOXC1 FOXJ2 (long isoform) FOXJ2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ABCC2 promoter sequence

Search SABiosciences Chromatin IP Primers for ABCC2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ABCC2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q24 Ensembl cytogenetic band: 10q24.2 HGNC cytogenetic band: 10q24

ABCC2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ABCC2 gene location

GeneLoc information about chromosome 10 GeneLoc Exon Structure

GeneLoc location for GC10P101532: view genomic region (about GC identifiers)

Start:	101,542,463 bp from pter	End:	101,611,949 bp from pter
Size:	69,487 bases	Orientation:	plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MRP2_HUMAN, Q92887 (See protein sequence)

Recommended Name: Canalicular multispecific organic anion transporter 1

Size: 1545 amino acids; 174207 Da

Subcellular location: Membrane; Multi-pass membrane protein

Secondary accessions: B2RMT8 Q14022 Q5T2B1 Q92500 Q92798 Q99663 Q9UMS2

Explore the universe of human proteins at neXtProt for ABCC2: NX_Q92887

Explore proteomics data for ABCC2 at MOPED

Post-translational modifications:

View modification sites using PhosphoSitePlus

View neXtProt modification sites for NX_Q92887

ABCC2 Protein expression data from MOPED¹, PaxDb² and MAXQB³ : About this image

REFSEQ proteins: NP_000383.1

ENSEMBL proteins:

ENSP00000359478 ENSP00000359463

Reactome Protein details: Q92887
Human Recombinant Protein Products for ABCC2:

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	Cloud-Clone Corp. Proteins for ABCC2

Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	TAS	--
GO:0005887	integral to plasma membrane	IEA	--
GO:0016020	membrane	--	--
GO:0016021	integral to membrane	--	--
GO:0016324	apical plasma membrane	ISS	--

ABCC2 for ontologies About GeneDecksing

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

HGNC Gene Families:

ABCC: ATP binding cassette transporters / subfamily C

IUPHAR Guide to PHARMACOLOGY protein family classification: ABCC2

ABCC subfamily

5/8 InterPro protein domains (see all 8):

IPR003439 ABC_transporter-like

IPR027417 P-loop_NTPase

IPR001140 ABC_transptr_TM_dom

IPR003593 AAA+_ATPase

IPR017940 ABC_transporter_type1

Graphical View of Domain Structure for InterPro Entry Q92887

ProtoNet protein and cluster: Q92887

UniProtKB/Swiss-Prot: MRP2_HUMAN, Q92887

Similarity: Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208)

subfamily

Similarity: Contains 2 ABC transmembrane type-1 domains

Similarity: Contains 2 ABC transporter domains

ABCC2 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: MRP2_HUMAN, Q92887

Function: Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin

transporter

Genatlas biochemistry entry for ABCC2:

ATP binding cassette superfamily,subfamily C (CFTR/MRP),member 2,mainly expressed in canilicular membranes of

hepatocytes,also present in other apical domains of prolonged cells,such as the epithelial cells of proximal

tubule of kidney

Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	--	--
GO:0005215	transporter activity	--	--
GO:0005515	protein binding	IPI	--
GO:0005524	ATP binding	IEA	--
GO:0008514	organic anion transmembrane transporter activity	TAS	7559771

ABCC2 for ontologies About GeneDecksing

Phenotypes:
4 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Abcc2):

hematopoietic system

homeostasis/metabolism

liver/biliary system

renal/urinary system

ABCC2 for phenotypes About GeneDecksing

Animal Models:
MGI mouse knock-out Abcc2^tm1Ahs for ABCC2

inGenious Targeting Laboratory - Custom generated mouse model solutions for ABCC2

inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ABCC2

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ABCC2

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ABCC2

miRNA Products:		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ABCC2
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate ABCC2
		SwitchGear 3'UTR luciferase reporter plasmid: ABCC2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene RNAi products in human, mouse, rat for ABCC2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ABCC2

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for ABCC2
			Sirion Biotech Customized adenovirus for overexpression of ABCC2

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
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		GenScript: all cDNA clones in your preferred vector: ABCC2 (NM_000392)
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		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ABCC2
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for ABCC2
		Search LifeMap BioReagents cell lines for ABCC2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ABCC2

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for ABCC2 About (see all 17)

See pathways by source

SuperPath

Contained pathways About

Irinotecan Pathway, Pharmacokinetics

Irinotecan Pathway, Pharmacokinetics	0.69	Irinotecan Pathway, Pharmacodynamics	0.50
Irinotecan Pathway	0.69	Taxane Pathway, Pharmacokinetics	0.30
Mycophenolic acid Pathway, Pharmacokinetics/Pharmacodynamics	0.50

Codeine and morphine metabolism

	Codeine and morphine metabolism	0.89			Tramadol Pharmacokinetics	0.36
	Codeine and Morphine Pathway, Pharmacokinetics	0.89

ABC-family proteins mediated transport

ABC-family proteins mediated transport

0.70

ABC transporters

0.70

Atorvastatin/Lovastatin/Simvastatin Pathway, Pharmacokinetics

	Atorvastatin/Lovastatin/Simvastatin Pathway, Pharmacokinetics	0.80			Ibuprofen Pathway, Pharmacokinetics	0.50
	Statin Pathway - Generalized, Pharmacokinetics	0.70

Pravastatin Pathway, Pharmacokinetics

Pravastatin Pathway, Pharmacokinetics

0.47

Methotrexate Pathway, Pharmacokinetics

0.47

Pathways by source See SuperPaths
Show all pathways

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for ABCC2

Hepatic ABC Transporters

1 Cell Signaling Technology (CST) Pathway for ABCC2

Glucose / Energy Metabolism

4 BioSystems Pathways for ABCC2

	Codeine and morphine metabolism
	Irinotecan Pathway
	Nuclear receptors in lipid metabolism and toxicity
	Drug Induction of Bile Acid Pathway

2 Reactome Pathways for ABCC2

	ABC-family proteins mediated transport
	Transmembrane transport of small molecules

5/18 PharmGKB Pathways for ABCC2 (see all 18)

	Atorvastatin/Lovastatin/Simvastatin Pathway, Pharmacokinetics
	Carbamazepine Pathway, Pharmacokinetics
	Codeine and Morphine Pathway, Pharmacokinetics
	Doxorubicin Pathway (Cancer Cell), Pharmacodynamics
	Doxorubicin Pathway, Pharmacokinetics

2 Kegg Pathways (Kegg details for ABCC2):

	ABC transporters
	Bile secretion

ABCC2 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for ABCC2

STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

5/13 Interacting proteins for ABCC2 (Q92887^{1, 3} ENSP00000359478⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 13)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
RDX	P35241³, ENSP00000342830⁴	I2D: score=2 STRING: ENSP00000342830
SLC9A3R1	O14745³, ENSP00000262613⁴	I2D: score=2 STRING: ENSP00000262613
PDZK1	Q5T2W1³, ENSP00000342143⁴	I2D: score=2 STRING: ENSP00000342143
CANX	P27824³, ENSP00000247461⁴	I2D: score=1 STRING: ENSP00000247461
PDZD3	Q86UT5³, ENSP00000327107⁴	I2D: score=1 STRING: ENSP00000327107

About this table

Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006810	transport	TAS	7559771
GO:0006855	drug transmembrane transport	IEA	--
GO:0006979	response to oxidative stress	IEA	--
GO:0009408	response to heat	IEA	--
GO:0015732	prostaglandin transport	IEA	--

ABCC2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

ABCC2 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Enzo Life Sciences drugs & compounds for ABCC2

Browse Tocris compounds for ABCC2 (MRP2)

2 HMDB Compounds for ABCC2 About this table

Compound	Synonyms	CAS #	PubMed Ids
Bilirubin	(4Z,15Z)-Bilirubin IXa (see all 17)	635-65-4	17517076
Pravastatin	3beta-Hydroxycompactin (see all 7)	81093-37-0	--

10/76 DrugBank Compounds for ABCC2 (see all 76) About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Sulfinpyrazone	Diphenylpyrazone (see all 6)	57-96-5	target	inhibitor	11834888 17229912 10727523 11108662 10917554 11500505
Sulfinpyrazone	Diphenylpyrazone (see all 6)	57-96-5	transporter	substrate inhibitor	11834888 17229912 10727523 11108662 10917554 11500505 11834888 10917554
Probenecid	--	57-66-9	transporter	substrate inhibitor	15618649 12608533 14511674 10727523 11880368 12538836 19319690
Cyclosporine	Ciclosporin (see all 4)	59865-13-3	transporter	inhibitor	10570049 15618649 12134946 14511674 10421658
Glutathione	5-L-Glutamyl-L-cysteinylglycine (see all 5)	70-18-8	transporter	substrate inhibitor	10024515 10692506 10648470 10491184 1430236
Methotrexate	Amethopterin (see all 12)	59-05-2	transporter	substrate inhibitor	9270020 12608533 10727523 11465411 10363967
Phenobarbital	Fenobarbital (see all 7)	50-06-6	transporter	inducer	11861969 11841808 11323161 9571149 11706036
Vinblastine	--	865-21-4	transporter	substrate inhibitor inducer	12134946 15616150 11323161 17045309 2172249
Indomethacin	IMN (see all 9)	53-86-1	transporter	substrate inhibitor	19541926 10870987 16460798 19319690
Pravastatin	--	81093-37-0	transporter	substrate inhibitor	11748225 15616150 9321514 15901800
Saquinavir	Saquinavir Mesylate (see all 2)	127779-20-8	transporter	substrate	15504753 12384350 12702717 12441801

10/146 Novoseek inferred chemical compound relationships for ABCC2 gene (see all 146) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
mk 571	90.7	12	17855498 (1), 18405608 (1), 18718123 (1), 19201990 (1) (see all 10)
oatp	86.7	15	17724432 (3), 20501720 (1), 19620935 (1), 18838068 (1) (see all 6)
gf 120918	85.6	6	19491037 (1), 18515333 (1), 16244858 (1)
estradiol-17beta-glucuronide	83.7	10	18180270 (2), 11748225 (1), 18761402 (1), 20071452 (1) (see all 5)
probenecid	79.5	32	15849751 (5), 15618649 (2), 15904671 (1), 18267365 (1) (see all 14)
androstane	79	10	11706036 (2), 15382119 (1), 20048746 (1), 19661216 (1) (see all 7)
psc-833	78.8	6	16356829 (1), 17543436 (1), 18195111 (1), 18515333 (1)
bilirubin monoglucuronide	78.5	7	11897625 (1), 19566819 (1), 9355767 (1), 19214140 (1) (see all 5)
s-(2,4-dinitrophenyl)glutathione	78.1	2	9794924 (1), 9525973 (1)
sulfinpyrazone	74.4	9	18180270 (2), 10917554 (1), 14569069 (1), 11500505 (1)

6 PharmGKB related drug/compound annotations for ABCC2 gene About this table

Drug/compound	PharmGKB Annotation
antiepileptics	CA
carbamazepine	CA
doxorubicin	CA
erythromycin	CA
talinolol	CA
tenofovir	CA

Search CenterWatch for drugs/clinical trials and news about ABCC2 / MRP2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ABCC2 gene:

NM_000392.3

Unigene Cluster for ABCC2:

ATP-binding cassette, sub-family C (CFTR/MRP), member 2

Hs.368243 [show with all ESTs]

Unigene Representative Sequence: U49248

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000370449(uc001kqf.2) ENST00000370434 ENST00000496621

miRNA Products:		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ABCC2
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		GenScript: all cDNA clones in your preferred vector: ABCC2 (NM_000392)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ABCC2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ABCC2

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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ABCC2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ABCC2

Additional mRNA sequence:

BC136419.1 U49248.1 U63970.1 X96395.2

8 DOTS entries:

DT.216029 DT.99999029 DT.121300501 DT.121300494 DT.216028 DT.100731911 DT.121300498 DT.92046395

24/76 AceView cDNA sequences (see all 76):

AA699522 AV656541 AV660932 BX643341 BQ220800 BM765259 BF589901 CA429833

BX495933 AI566147 R02136 U49248 AV660925 CB155960 AV652973 AA706096

AA931070 BM804774 NM_000392 BP359602 AA187829 BX116034 AI522182 AI823554

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ABCC2 expression in normal human tissues (normalized intensities) ABCC2 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: AACCTACTAC

About this image

ABCC2 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database

5/7 selected tissues (see all 7) fully expand


Liver (Hepatobiliary System)
Hepatocytes Liver Lobule

Intestine (Gastrointestinal Tract)
small intestine

Adipose (Muscoskeletal System)
Human Preadipocyte-visceral (HPA-v)

Kidney (Urinary System)
kidney ; cells in tubules

Gall Bladder (Hepatobiliary System)
gallbladder ; glandular cells

See ABCC2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ABCC2

SOURCE GeneReport for Unigene cluster: Hs.368243

UniProtKB/Swiss-Prot: MRP2_HUMAN, Q92887

Tissue specificity: Found on the apical membrane of polarized cells in liver, kidney and intestine. The highest

expression is found in liver

SABiosciences Expression via Pathway-Focused PCR Arrays including ABCC2:

Nephrotoxicity in human mouse rat

Drug Transporters in human mouse rat

Cancer Drug Resistance in human mouse rat

Hepatotoxicity in human mouse rat

Molecular Toxicology PathwayFinder 384HT in human mouse rat

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ABCC2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ABCC2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for ABCC2 gene from 8/18 species (see all 18) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Abcc2^{1 , 5}	ATP-binding cassette, sub-family C (CFTR/MRP), member more^{1, 5}	80.91(n)¹ 77.76(a)¹		19 (36.67 cM)⁵ 12780¹ NM_013806.2¹ NP_038834.2¹ 43782192⁵
chicken (Gallus gallus)	Aves	ABCC2¹	ATP-binding cassette, sub-family C (CFTR/MRP), member more	65.6(n) 63.91(a)		423828 XM_421698.3 XP_421698.3
lizard (Anolis carolinensis)	Reptilia	ABCC2⁶	Uncharacterized protein	64(a)	1 ↔ 1	3(38272079-38308779)
zebrafish (Danio rerio)	Actinopterygii	zgc66072²	similar to multidrug resistance protein 2	73.77(n)		393561 BC056740.1
fruit fly (Drosophila melanogaster)	Insecta	Sur³	heart development sulfonylurea receptor	46(a) (best of 2)		31B1 --
worm (Caenorhabditis elegans)	Secernentea	mrp-2³	ATP-binding transport family	41(a) (best of 3)		X(599137-607953) --
thale cress (Arabidopsis thaliana)	eudicotyledons	MRP1¹	ABC transporter C family member 1	50.01(n) 42.47(a)		839920 NM_001036039.1 NP_001031116.1
rice (Oryza sativa)	Liliopsida	AK120122.1²	--	73.92(n)		AK120122.1

ENSEMBL Gene Tree for ABCC2 (if available)
TreeFam Gene Tree for ABCC2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ABCC2 gene

ABCC4² ABCC12² ABCC10² ABCC1² CFTR² ABCC8² ABCC5² ABCC3²

ABCC11² ABCC9²

18/20 SIMAP similar genes for ABCC2 using alignment to 2 protein entries: MRP2_HUMAN (see all proteins) (see all similar genes):

TAP1 DKFZp434I2115 DKFZp781G125 NG-TRA ABCB4 MRP3

CFTR ABCC3 MOAT-B ABCC1 ABCC4 ABCC6

MRP ABCC11 ABCC12 ABCC9 ABCC10 ara

ABCC2 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for ABCC2
PGOHUM00000258120

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 10 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
VAR_013327⁴		Dubin-Johnson syndrome (DJS)⁴	--	see VAR_013327	2	R H	mis⁴		0	--	--	--	--
VAR_013328⁴		Dubin-Johnson syndrome (DJS)⁴	--	see VAR_013328	2	I F	mis⁴		0	--	--	--	--
VAR_010756⁴		Dubin-Johnson syndrome (DJS)⁴	--	see VAR_010756	2	Q R	mis⁴		0	--	--	--	--
rs56199535^1,2,4	C,F	Dubin-Johnson syndrome (DJS)⁴ pathogenic¹	101578577(+)	`AGCAGC/G/TGGATC`	2	R W	mis¹		5		MN WA EA CSA	841
rs72558200^1,2	C	pathogenic¹	101595882(+)	`GAGGCA/GTCTGG`	2	H R	mis¹		0	--	--	--	--
rs72558201^1,2	C	pathogenic¹	101595950(+)	`CAGTTA/TTCCGT`	2	I F	mis¹		0	--	--	--	--
rs72558202^1,2	C	pathogenic¹	101605538(+)	`CCCCCA/GGGTGA`	2	Q R	mis¹		0	--	--	--	--
VAR_047152⁴		--	--	see VAR_047152	2	Y F	mis⁴		0	--	--	--	--
rs187230151^1,2		--	101540642(+)	`AAAGGC/TGCACC`	1	--	us2k¹		0	--	--	--	--
rs148837420^1,2		--	101540647(+)	`TGCACA/CCTGCC`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for ABCC2 (101542463 - 101611949 bp)

Structural Variations
Database of Genomic Variants (DGV) 7 variations for ABCC2: About this table

Variant ID	Type	Subtype	PubMed ID
nsv825539	CNV	Loss	20364138
nsv895918	CNV	Loss	21882294
dgv805n71	CNV	Loss	21882294
nsv895921	CNV	Loss	21882294
nsv895917	CNV	Loss	21882294
nsv831960	CNV	Gain	17160897
nsv825540	CNV	Gain	20364138

Human Gene Mutation Database (HGMD): ABCC2

SABiosciences Cancer Mutation PCR Assays

SeqTarget long-range PCR primers for resequencing ABCC2

DNA2.0 Custom Variant and Variant Library Synthesis for ABCC2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

OMIM gene information: 601107
OMIM disorders: 237500
UniProtKB/Swiss-Prot: MRP2_HUMAN, Q92887

Dubin-Johnson syndrome (DJS) [MIM:237500]: Autosomal recessive disorder characterized by conjugated

hyperbilirubinemia, an increase in the urinary excretion of coproporphyrin isomer I, deposition of melanin-like

pigment in hepatocytes, and prolonged retention of sulfobromophthalein, but otherwise normal liver function.

Note=The disease is caused by mutations affecting the gene represented in this entry

20/76 diseases for ABCC2 (see all 76): About MalaCards

dubin-johnson syndrome rotor syndrome cholestasis intrahepatic cholestasis of pregnancy

dysembryoplastic neuroepithelial tumor intrahepatic cholestasis cholangitis factor vii deficiency

hepatocellular adenoma central nervous system lymphoma hepatoblastoma obstructive jaundice

sclerosing cholangitis malignant mesothelioma primary sclerosing cholangitis biliary atresia

leukopenia primary biliary cirrhosis jaundice nasopharyngitis

3 diseases from the University of Copenhagen DISEASES database for ABCC2:

Bilirubin metabolic disorder Cholestasis Cancer

ABCC2 for disorders About GeneDecksing

Congresses - knowledge worth sharing:
Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

10/57 Novoseek inferred disease relationships for ABCC2 gene (see all 57) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
dubin-johnson syndrome	95.3	83	11477083 (3), 10464142 (3), 19881259 (2), 15777714 (2) (see all 42)
hyperbilirubinemia	74.5	41	15965653 (4), 19881259 (2), 15870973 (2), 12884082 (2) (see all 20)
cholestasis	71.3	31	18700187 (3), 2035335 (3), 11481619 (2), 15057744 (2) (see all 17)
cholestasis intrahepatic	63.8	3	17997497 (2), 19882051 (1)
rotor syndrome	59.4	1	7483689 (1)
breast cancer	56.9	95	18845662 (2), 20071452 (2), 20441926 (2), 15180326 (1) (see all 56)
ovarian carcinoma	46.6	22	10767994 (5), 10537344 (4), 15262134 (3), 12216079 (2) (see all 9)
colon adenocarcinoma	42.9	2	15896333 (1), 17430634 (1)
cancer	40	46	10427140 (3), 9398612 (3), 8797578 (1), 9270026 (1) (see all 32)
liver diseases	36.5	22	17725603 (4), 18926681 (2), 9185779 (1), 10319416 (1) (see all 8)

Genetic Association Database (GAD): ABCC2
Human Genome Epidemiology (HuGE) Navigator: ABCC2 (89 documents)

Export disorders for ABCC2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ABCC2 gene, integrated from 9 sources (see all 812):
(articles sorted by number of sources associating them with ABCC2)

Utopia: connect your pdf to the dynamic
world of online information

Mutation of Trp1254 in the multispecific organic anion transporter, multidrug resistance protein 2 (MRP2) (ABCC2), alters substrate specificity and results in loss of methotrexate transport activity. (PubMed id 11500505)^{1, 2, 7, 9} Ito K....Cole S.P.C. (2001)
Non-response to antiepileptic pharmacotherapy is associated with the ABCC2 -24C>T polymorphism in young and adult patients with epilepsy. (PubMed id 19415824)^{1, 4, 7, 9} Ufer M....Cascorbi I. (2009)
High-dose methotrexate in pediatric acute lymphoblastic leukemia: impact of ABCC2 polymorphisms on plasma concentrations. (PubMed id 17112803)^{1, 4, 7, 9} Rau T....Langer T. (2006)
Association between ABCC2 gene haplotypes and tenofovir-induced proximal tubulopathy. (PubMed id 17083032)^{1, 4, 7, 9} Izzedine H....Deray A.G. (2006)
A human canalicular multispecific organic anion transporter (cMOAT) gene is overexpressed in cisplatin-resistant human cancer cell lines with decreased drug accumulation. (PubMed id 8797578)^{1, 2, 3, 9} Taniguchi K.... Kuwano M. (1996)
Integrated pharmacogenetic prediction of irinotecan pharmacokinetics and toxicity in patients with advanced non-small cell lung cancer. (PubMed id 18221820)^{1, 4, 7} Han J.Y....Lee J.S. (2008)
Identification and functional analysis of two novel mutations in the multidrug resistance protein 2 gene in Israeli patients with Dubin- Johnson syndrome. (PubMed id 11477083)^{1, 2, 9} Mor-Cohen R....Seligsohn U. (2001)
Multidrug resistance-related protein 2 genotype of the donor affects kidney graft function. (PubMed id 19214140)^{1, 4, 9} Grisk O....Rettig R. (2009)
Exon-intron organization of the human multidrug-resistance protein 2 (MRP2) gene mutated in Dubin-Johnson syndrome. (PubMed id 10464142)^{1, 2, 9} Tsujii H.... Keppler D. (1999)
MRP2 haplotypes confer differential susceptibility to toxic liver injury. (PubMed id 17502832)^{1, 4, 9} Choi J.H....Lee M.G. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 1244	HGNC: 53	AceView: ABCC2	Ensembl:ENSG00000023839	euGenes: HUgn1244
ECgene: ABCC2	Kegg: 1244	H-InvDB: ABCC2

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ABCC2	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for ABCC2	Genetics and Cytogenetics in Oncology and Haematology
GeneReviews	http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/ABCC2
ABCMdb	http://abcmutations.hegelab.org/proteinDetails?uniprot_id=Q92887

Intellectual Property for ABCC2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for ABCC2 gene:
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GeneCards and IP:
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ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 2

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ABCC2 Gene

ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 2

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