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ABCC2 Gene

protein-coding GIFtS: 67
GCID: GC10P101532

ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 2

(Previous name: canalicular multispecific organic anion transporter 1)
(Previous symbol: CMOAT)

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Aliases
ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 2¹ ²		ATP-Binding Cassette Sub-Family C Member 2² ³
CMOAT¹ ² ³ ⁵		ABC30²
Canalicular Multispecific Organic Anion Transporter 1¹ ²		DJS²
Canalicular Multidrug Resistance Protein² ³		cMRP²
Multidrug Resistance-Associated Protein 2² ³		CMOAT1³
MRP2² ³		CMRP³

External Ids:	HGNC: 53¹	Entrez Gene: 1244²	Ensembl: ENSG00000023839⁷	OMIM: 601107⁵	UniProtKB: Q92887³

Export aliases for ABCC2 gene to outside databases

Previous GC identifers: GC10P100435 GC10P100776 GC10P101673 GC10P101207 GC10P095169

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ABCC2 Gene:

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC

proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven

distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily

which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the

hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine;

therefore, this protein appears to contribute to drug resistance in mammalian cells. Several different mutations

in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder

characterized by conjugated hyperbilirubinemia. (provided by RefSeq, Jul 2008)

GeneCards Summary for ABCC2 Gene:

ABCC2 (ATP-binding cassette, sub-family C (CFTR/MRP), member 2) is a protein-coding gene. Diseases associated with ABCC2 include dubin-johnson syndrome, and rotor syndrome. GO annotations related to this gene include organic anion transmembrane transporter activity and protein domain specific binding. An important paralog of this gene is ABCC4.

UniProtKB/Swiss-Prot: MRP2_HUMAN, Q92887

Function: Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin

transporter

Gene Wiki entry for ABCC2 (Multidrug resistance-associated protein 2) Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:

NC_000010.11 NT_030059.14 NC_018921.2

Regulatory elements:

Regulatory transcription factor binding sites in the ABCC2 gene promoter:
HFH-3 Sox5 GATA-3 FOXD3 GATA-2 FOXL1 FOXI1 FOXC1 FOXJ2 (long isoform) FOXJ2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ABCC2 promoter sequence

Search Chromatin IP Primers for ABCC2

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ABCC2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q24 Ensembl cytogenetic band: 10q24.2 HGNC cytogenetic band: 10q24

ABCC2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ABCC2 gene location

GeneLoc information about chromosome 10 GeneLoc Exon Structure

GeneLoc location for GC10P101532: view genomic region (about GC identifiers)

Start:	101,542,463 bp from pter	End:	101,611,949 bp from pter
Size:	69,487 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: MRP2_HUMAN, Q92887 (See protein sequence)

Recommended Name: Canalicular multispecific organic anion transporter 1

Size: 1545 amino acids; 174207 Da

Secondary accessions: B2RMT8 Q14022 Q5T2B1 Q92500 Q92798 Q99663 Q9UMS2

Explore the universe of human proteins at neXtProt for ABCC2: NX_Q92887

Explore proteomics data for ABCC2 at MOPED

Post-translational modifications:

Glycosylation² at Asn7, Asn12, Asn1011

Modification sites at PhosphoSitePlus

See ABCC2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_000383.1

ENSEMBL proteins:

ENSP00000359478 ENSP00000359463

Reactome Protein details: Q92887

ABCC2 Human Recombinant Protein Products:

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ABCC2 Antibody Products:

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ABCC2 Assay Products:

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	Cloud-Clone Corp. ELISAs for ABCC2 Cloud-Clone Corp. CLIAs for ABCC2

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:

ABCC: ATP binding cassette transporters / subfamily C

IUPHAR Guide to PHARMACOLOGY protein family classification: ABCC2

ABCC subfamily

Selected InterPro protein domains (see all 7):

IPR003439 ABC_transporter-like

IPR027417 P-loop_NTPase

IPR001140 ABC_transptr_TM_dom

IPR003593 AAA+_ATPase

IPR011527 ABC1_TM_dom

Graphical View of Domain Structure for InterPro Entry Q92887

ProtoNet protein and cluster: Q92887

UniProtKB/Swiss-Prot: MRP2_HUMAN, Q92887

Similarity: Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208)

subfamily

Similarity: Contains 2 ABC transmembrane type-1 domains

Similarity: Contains 2 ABC transporter domains

ABCC2 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

UniProtKB/Swiss-Prot Summary: MRP2_HUMAN, Q92887

Function: Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin

transporter

Genatlas biochemistry entry for ABCC2:

ATP binding cassette superfamily,subfamily C (CFTR/MRP),member 2,mainly expressed in canilicular membranes of

hepatocytes,also present in other apical domains of prolonged cells,such as the epithelial cells of proximal

tubule of kidney

Gene Ontology (GO): Selected molecular function terms (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	--	--
GO:0005215	transporter activity	--	--
GO:0005515	protein binding	IPI	--
GO:0005524	ATP binding	IEA	--
GO:0008514	organic anion transmembrane transporter activity	TAS	7559771

ABCC2 for ontologies About GeneDecksing

Phenotypes:
4 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Abcc2):

hematopoietic system

homeostasis/metabolism

liver/biliary system

renal/urinary system

ABCC2 for phenotypes About GeneDecksing

Animal Models:
MGI mouse knock-out Abcc2^tm1Ahs for ABCC2

inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ABCC2

inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ABCC2

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ABCC2

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ABCC2

miRNA Products:		Block miRNA regulation of human, mouse, rat ABCC2 using miScript Target Protectors
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Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for ABCC2
		Predesigned siRNA for gene silencing in human, mouse, rat ABCC2

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for ABCC2

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		GenScript: all cDNA clones in your preferred vector: ABCC2 (NM_000392)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ABCC2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ABCC2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for ABCC2
		Browse ESI BIO Cell Lines and PureStem Progenitors for ABCC2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ABCC2

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot

MRP2_HUMAN, Q92887: Apical cell membrane; Multi-pass membrane protein

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
plasma membrane	4
nucleus	2
cytoskeleton	1
extracellular	1

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Gene Ontology (GO): Selected cellular component terms (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	TAS	--
GO:0005887	integral component of plasma membrane	IEA	--
GO:0016020	membrane	--	--
GO:0016021	integral component of membrane	--	--
GO:0016324	apical plasma membrane	IDA	11093739

ABCC2 for ontologies About GeneDecksing

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for ABCC2 About (see all 17)

See pathways by source

SuperPath

Contained pathways About

Irinotecan Pathway, Pharmacokinetics

Irinotecan Pathway, Pharmacokinetics	0.69	Irinotecan Pathway, Pharmacodynamics	0.50
Irinotecan Pathway	0.69	Taxane Pathway, Pharmacokinetics	0.30
Mycophenolic acid Pathway, Pharmacokinetics/Pharmacodynamics	0.50

Codeine and Morphine Pathway, Pharmacokinetics

	Codeine and Morphine Pathway, Pharmacokinetics	0.33			Codeine and morphine metabolism	0.00
	Tramadol Pharmacokinetics	0.33

ABC-family proteins mediated transport

ABC-family proteins mediated transport

0.69

ABC transporters

0.69

Statin Pathway - Generalized, Pharmacokinetics

	Statin Pathway - Generalized, Pharmacokinetics	0.50			Atorvastatin/Lovastatin/Simvastatin Pathway, Pharmacokinetics	0.00
	Ibuprofen Pathway, Pharmacokinetics	0.50			Pravastatin Pathway, Pharmacokinetics	0.00

Doxorubicin Pathway, Pharmacokinetics

Doxorubicin Pathway (Cancer Cell), Pharmacodynamics

0.43

Doxorubicin Pathway, Pharmacokinetics

0.43

Pathways by source See SuperPaths
Show all pathways

1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for ABCC2

Hepatic ABC Transporters

1 Cell Signaling Technology (CST) Pathway for ABCC2

Glucose / Energy Metabolism

4 BioSystems Pathways for ABCC2

	Codeine and morphine metabolism
	Irinotecan Pathway
	Nuclear receptors in lipid metabolism and toxicity
	Drug Induction of Bile Acid Pathway

1 Reactome Pathway for ABCC2

ABC-family proteins mediated transport

Selected PharmGKB Pathways for ABCC2 (see all 18)

	Atorvastatin/Lovastatin/Simvastatin Pathway, Pharmacokinetics
	Carbamazepine Pathway, Pharmacokinetics
	Codeine and Morphine Pathway, Pharmacokinetics
	Doxorubicin Pathway (Cancer Cell), Pharmacodynamics
	Doxorubicin Pathway, Pharmacokinetics

2 Kegg Pathways (Kegg details for ABCC2):

	ABC transporters
	Bile secretion

ABCC2 for pathways About GeneDecksing

Pathway & Disease-focused RT² Profiler PCR Arrays including ABCC2:

Nephrotoxicity in human mouse rat

Drug Transporters in human mouse rat

Cancer Drug Resistance in human mouse rat

Hepatotoxicity in human mouse rat

Molecular Toxicology PathwayFinder 384HT in human mouse rat

Interactions:

GeneGlobe Interaction Network for ABCC2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for ABCC2 (Q92887^{1, 3} ENSP00000359478⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 30)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
RDX	P35241³, ENSP00000342830⁴	I2D: score=2 STRING: ENSP00000342830
SLC9A3R1	O14745³, ENSP00000262613⁴	I2D: score=2 STRING: ENSP00000262613
PDZK1	Q5T2W1³, ENSP00000342143⁴	I2D: score=2 STRING: ENSP00000342143
CANX	P27824³, ENSP00000247461⁴	I2D: score=1 STRING: ENSP00000247461
PDZD3	Q86UT5³, ENSP00000327107⁴	I2D: score=1 STRING: ENSP00000327107

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Gene Ontology (GO): Selected biological process terms (see all 12): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006810	transport	TAS	7559771
GO:0006855	drug transmembrane transport	IEA	--
GO:0006979	response to oxidative stress	IEA	--
GO:0009408	response to heat	IEA	--
GO:0015732	prostaglandin transport	IEA	--

ABCC2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

Enzo Life Sciences drugs & compounds for ABCC2

Browse compounds at ApexBio

Browse Tocris compounds for ABCC2 (MRP2)

2 HMDB Compounds for ABCC2 About this table

Compound	Synonyms	CAS #	PubMed Ids
Bilirubin	(4Z,15Z)-Bilirubin IXa (see all 17)	635-65-4	17517076
Pravastatin	3beta-Hydroxycompactin (see all 7)	81093-37-0	--

Selected DrugBank Compounds for ABCC2 (see all 76) About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Sulfinpyrazone	Diphenylpyrazone (see all 6)	57-96-5	target	inhibitor	11834888 17229912 10727523 11108662 10917554 11500505
Sulfinpyrazone	Diphenylpyrazone (see all 6)	57-96-5	transporter	substrate inhibitor	11834888 17229912 10727523 11108662 10917554 11500505 11834888 10917554
Probenecid	--	57-66-9	transporter	substrate inhibitor	15618649 12608533 14511674 10727523 11880368 12538836 19319690
Cyclosporine	Ciclosporin (see all 4)	59865-13-3	transporter	inhibitor	10570049 15618649 12134946 14511674 10421658
Glutathione	5-L-Glutamyl-L-cysteinylglycine (see all 5)	70-18-8	transporter	substrate inhibitor	10024515 10692506 10648470 10491184 1430236
Methotrexate	Amethopterin (see all 12)	59-05-2	transporter	substrate inhibitor	9270020 12608533 10727523 11465411 10363967
Phenobarbital	Fenobarbital (see all 7)	50-06-6	transporter	inducer	11861969 11841808 11323161 9571149 11706036
Vinblastine	--	865-21-4	transporter	substrate inhibitor inducer	12134946 15616150 11323161 17045309 2172249
Indomethacin	IMN (see all 9)	53-86-1	transporter	substrate inhibitor	19541926 10870987 16460798 19319690
Pravastatin	--	81093-37-0	transporter	substrate inhibitor	11748225 15616150 9321514 15901800
Saquinavir	Saquinavir Mesylate (see all 2)	127779-20-8	transporter	substrate	15504753 12384350 12702717 12441801

Selected Novoseek inferred chemical compound relationships for ABCC2 gene (see all 146) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
mk 571	90.7	12	17855498 (1), 18405608 (1), 18718123 (1), 19201990 (1) (see all 10)
oatp	86.7	15	17724432 (3), 20501720 (1), 19620935 (1), 18838068 (1) (see all 6)
gf 120918	85.6	6	19491037 (1), 18515333 (1), 16244858 (1)
estradiol-17beta-glucuronide	83.7	10	18180270 (2), 11748225 (1), 18761402 (1), 20071452 (1) (see all 5)
probenecid	79.5	32	15849751 (5), 15618649 (2), 15904671 (1), 18267365 (1) (see all 14)
androstane	79	10	11706036 (2), 15382119 (1), 20048746 (1), 19661216 (1) (see all 7)
psc-833	78.8	6	16356829 (1), 17543436 (1), 18195111 (1), 18515333 (1)
bilirubin monoglucuronide	78.5	7	11897625 (1), 19566819 (1), 9355767 (1), 19214140 (1) (see all 5)
s-(2,4-dinitrophenyl)glutathione	78.1	2	9794924 (1), 9525973 (1)
sulfinpyrazone	74.4	9	18180270 (2), 10917554 (1), 14569069 (1), 11500505 (1)

6 PharmGKB related drug/compound annotations for ABCC2 gene About this table

Drug/compound	PharmGKB Annotation
antiepileptics	CA
carbamazepine	CA
doxorubicin	CA
erythromycin	CA
talinolol	CA
tenofovir	CA

ABCC2 for compounds About GeneDecksing

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for ABCC2 gene:

NM_000392.4

Unigene Cluster for ABCC2:

ATP-binding cassette, sub-family C (CFTR/MRP), member 2

Hs.368243 [show with all ESTs]

Unigene Representative Sequence: U49248

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000370449(uc001kqf.2) ENST00000370434 ENST00000496621

miRNA Products:		Block miRNA regulation of human, mouse, rat ABCC2 using miScript Target Protectors
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		GenScript: all cDNA clones in your preferred vector: ABCC2 (NM_000392)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ABCC2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ABCC2

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for ABCC2
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat ABCC2
		QuantiTect SYBR Green Assays in human, mouse, rat ABCC2
		QuantiFast Probe-based Assays in human, mouse, rat ABCC2

Additional mRNA sequence:

BC136419.1 U49248.1 U63970.1 X96395.2

8 DOTS entries:

DT.216029 DT.99999029 DT.121300501 DT.121300494 DT.216028 DT.100731911 DT.121300498 DT.92046395

Selected AceView cDNA sequences (see all 76):

CA429833 BQ220800 BX643341 AA699522 AV660932 AV656541 BF589901 BM765259

BM741963 AV652973 U63970 AA931070 CB155960 BX116034 BX495933 BM804774

AI823554 NM_000392 AI522182 U49248 AI566147 BU634041 AA706096 AA187829

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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ABCC2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: AACCTACTAC

About this image

ABCC2 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database
selected tissues (see all 3) fully expand


Brain (Nervous System) fully expand to see all 2 entries
Cerebral Cortex
Mature brain microvascular endothelial cells

Liver (Hepatobiliary System)
Hepatocytes Liver Lobule

Endothelium (Cardiovascular System)
Mature brain microvascular endothelial cells

ABCC2 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

ABCC2 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.368243

UniProtKB/Swiss-Prot: MRP2_HUMAN, Q92887

Tissue specificity: Expressed by polarized cells in liver, kidney and intestine. The highest expression is found

in liver

Pathway & Disease-focused RT² Profiler PCR Arrays including ABCC2:

Nephrotoxicity in human mouse rat

Drug Transporters in human mouse rat

Cancer Drug Resistance in human mouse rat

Hepatotoxicity in human mouse rat

Molecular Toxicology PathwayFinder 384HT in human mouse rat

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for ABCC2
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat ABCC2
		QuantiTect SYBR Green Assays in human, mouse, rat ABCC2
		QuantiFast Probe-based Assays in human, mouse, rat ABCC2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ABCC2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of eukaryotes.

Orthologs for ABCC2 gene from Selected species (see all 20) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Abcc2^{1 , 5}	ATP-binding cassette, sub-family C (CFTR/MRP), member more^{1, 5}	80.9(n)¹ 77.71(a)¹		19 (36.67 cM)⁵ 12780¹ NM_013806.2¹ NP_038834.2¹ 43782192⁵
chicken (Gallus gallus)	Aves	ABCC2¹	ATP-binding cassette, sub-family C (CFTR/MRP), member more	65.47(n) 63.52(a)		423828 XM_421698.4 XP_421698.4
lizard (Anolis carolinensis)	Reptilia	ABCC2⁶	ATP-binding cassette, sub-family C (CFTR/MRP), mem...	64(a)	1 ↔ 1	3(38272079-38308779)
tropical clawed frog (Xenopus tropicalis)	Amphibia	abcc2¹	ATP-binding cassette, sub-family C (CFTR/MRP), member more	64.17(n) 63.43(a)		100485020 XM_004915869.1 XP_004915926.1
zebrafish (Danio rerio)	Actinopterygii	zgc66072²	similar to multidrug resistance protein 2	73.77(n)		393561 BC056740.1
fruit fly (Drosophila melanogaster)	Insecta	Sur³	heart development sulfonylurea receptor	46(a) (best of 2)		31B1 --
worm (Caenorhabditis elegans)	Secernentea	mrp-2³	ATP-binding transport family	41(a) (best of 3)		X(599137-607953) --
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	NFT1(YKR103W)⁴	Putative transporter of the multidrug resistance-associated more	--		11(653080-656736) 853978 NP_013029.1
thale cress (Arabidopsis thaliana)	eudicotyledons	MRP1¹	MRP1	50.33(n) 42.88(a)		839920 NM_102777.2 NP_174329.1
rice (Oryza sativa)	Liliopsida	AK120122.1²	--	73.92(n)		AK120122.1

ENSEMBL Gene Tree for ABCC2 (if available)
TreeFam Gene Tree for ABCC2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for ABCC2 gene

ABCC4² ABCC12² ABCC1² ABCC8² ABCC5² ABCC6² ABCC3² ABCC9²

ABCC11²

Selected SIMAP similar genes for ABCC2 using alignment to 2 protein entries: MRP2_HUMAN (see all proteins) (see all similar genes):

TAP1 DKFZp434I2115 DKFZp781G125 NG-TRA ABCB4 MRP3

CFTR ABCC3 MOAT-B ABCC1 ABCC4 ABCC6

MRP ABCC11 ABCC12 ABCC9 ABCC10 ara

ABCC2 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for ABCC2
PGOHUM00000258120

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 10 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs56199535^1,2,,4	C,F	Dubin-Johnson syndrome (DJS)⁴ pathogenic¹	101578577(+)	`AGCAGC/G/TGGATC`	2	R W	mis¹		5		MN WA EA CSA	841
VAR_013327⁴		Dubin-Johnson syndrome (DJS)⁴	--	see VAR_013327	2	R H	mis⁴		0	--	--	--	--
VAR_013328⁴		Dubin-Johnson syndrome (DJS)⁴	--	see VAR_013328	2	I F	mis⁴		0	--	--	--	--
VAR_010756⁴		Dubin-Johnson syndrome (DJS)⁴	--	see VAR_010756	2	Q R	mis⁴		0	--	--	--	--
rs72558200^1,2	C	pathogenic¹	101595882(+)	`GAGGCA/GTCTGG`	2	H R	mis¹		0	--	--	--	--
rs72558201^1,2	C	pathogenic¹	101595950(+)	`CAGTTA/TTCCGT`	2	I F	mis¹		0	--	--	--	--
rs72558202^1,2	C	pathogenic¹	101605538(+)	`CCCCCA/GGGTGA`	2	Q R	mis¹		0	--	--	--	--
rs187230151^1,2		--	101540642(+)	`AAAGGC/TGCACC`	1	--	us2k¹		0	--	--	--	--
rs148837420^1,2		--	101540647(+)	`TGCACA/CCTGCC`	1	--	us2k¹		0	--	--	--	--
rs146969653^1,2		--	101540674(+)	`AGTTCC/TACAGC`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for ABCC2 (101542463 - 101611949 bp)

Structural Variations
Database of Genomic Variants (DGV) 7 variations for ABCC2: About this table

Variant ID	Type	Subtype	PubMed ID
nsv825539	CNV	Loss	20364138
nsv895918	CNV	Loss	21882294
dgv805n71	CNV	Loss	21882294
nsv895921	CNV	Loss	21882294
nsv895917	CNV	Loss	21882294
nsv831960	CNV	Gain	17160897
nsv825540	CNV	Gain	20364138

Human Gene Mutation Database (HGMD): ABCC2

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing ABCC2

DNA2.0 Custom Variant and Variant Library Synthesis for ABCC2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 601107
OMIM disorders: 237500
UniProtKB/Swiss-Prot: MRP2_HUMAN, Q92887

Dubin-Johnson syndrome (DJS) [MIM:237500]: Autosomal recessive disorder characterized by conjugated

hyperbilirubinemia, an increase in the urinary excretion of coproporphyrin isomer I, deposition of melanin-like

pigment in hepatocytes, and prolonged retention of sulfobromophthalein, but otherwise normal liver function.

Note=The disease is caused by mutations affecting the gene represented in this entry

Selected diseases for ABCC2 (see all 79):
About MalaCards

dubin-johnson syndrome rotor syndrome fallopian tube cancer dysembryoplastic neuroepithelial tumor

intrahepatic cholestasis of pregnancy cholestasis intrahepatic cholestasis factor vii deficiency

cholangitis hepatocellular adenoma bilirubin metabolic disorder central nervous system lymphoma

obstructive jaundice hepatoblastoma sclerosing cholangitis primary sclerosing cholangitis

malignant mesothelioma ovarian cancer biliary atresia leukopenia

3 diseases from the University of Copenhagen DISEASES database for ABCC2:

Bilirubin metabolic disorder Cholestasis Cancer

ABCC2 for disorders About GeneDecksing

Congresses - knowledge worth sharing:
The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

Selected Novoseek inferred disease relationships for ABCC2 gene (see all 57) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
dubin-johnson syndrome	95.3	83	11477083 (3), 10464142 (3), 19881259 (2), 15777714 (2) (see all 42)
hyperbilirubinemia	74.5	41	15965653 (4), 19881259 (2), 15870973 (2), 12884082 (2) (see all 20)
cholestasis	71.3	31	18700187 (3), 2035335 (3), 11481619 (2), 15057744 (2) (see all 17)
cholestasis intrahepatic	63.8	3	17997497 (2), 19882051 (1)
rotor syndrome	59.4	1	7483689 (1)
breast cancer	56.9	95	18845662 (2), 20071452 (2), 20441926 (2), 15180326 (1) (see all 56)
ovarian carcinoma	46.6	22	10767994 (5), 10537344 (4), 15262134 (3), 12216079 (2) (see all 9)
colon adenocarcinoma	42.9	2	15896333 (1), 17430634 (1)
cancer	40	46	10427140 (3), 9398612 (3), 8797578 (1), 9270026 (1) (see all 32)
liver diseases	36.5	22	17725603 (4), 18926681 (2), 9185779 (1), 10319416 (1) (see all 8)

Genetic Association Database (GAD): ABCC2
Human Genome Epidemiology (HuGE) Navigator: ABCC2 (89 documents)

Export disorders for ABCC2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for ABCC2 gene, integrated from 10 sources (see all 818):
(articles sorted by number of sources associating them with ABCC2)

Utopia: connect your pdf to the dynamic
world of online information

Mutation of Trp1254 in the multispecific organic anion transporter, multidrug resistance protein 2 (MRP2) (ABCC2), alters substrate specificity and results in loss of methotrexate transport activity. (PubMed id 11500505)^{1, 2, 7, 9} Ito K....Cole S.P.C. (J. Biol. Chem. 2001)
Non-response to antiepileptic pharmacotherapy is associated with the ABCC2 -24C>T polymorphism in young and adult patients with epilepsy. (PubMed id 19415824)^{1, 4, 7, 9} Ufer M....Cascorbi I. (Pharmacogenet. Genomics 2009)
High-dose methotrexate in pediatric acute lymphoblastic leukemia: impact of ABCC2 polymorphisms on plasma concentrations. (PubMed id 17112803)^{1, 4, 7, 9} Rau T....Langer T. (Clin. Pharmacol. Ther. 2006)
Association between ABCC2 gene haplotypes and tenofovir-induced proximal tubulopathy. (PubMed id 17083032)^{1, 4, 7, 9} Izzedine H....Deray A.G. (J. Infect. Dis. 2006)
A human canalicular multispecific organic anion transporter (cMOAT) gene is overexpressed in cisplatin-resistant human cancer cell lines with decreased drug accumulation. (PubMed id 8797578)^{1, 2, 3, 9} Taniguchi K.... Kuwano M. (Cancer Res. 1996)
Integrated pharmacogenetic prediction of irinotecan pharmacokinetics and toxicity in patients with advanced non-small cell lung cancer. (PubMed id 18221820)^{1, 4, 7} Han J.Y....Lee J.S. (Lung Cancer 2009)
Identification and functional analysis of two novel mutations in the multidrug resistance protein 2 gene in Israeli patients with Dubin- Johnson syndrome. (PubMed id 11477083)^{1, 2, 9} Mor-Cohen R....Seligsohn U. (J. Biol. Chem. 2001)
Multidrug resistance-related protein 2 genotype of the donor affects kidney graft function. (PubMed id 19214140)^{1, 4, 9} Grisk O....Rettig R. (Pharmacogenet. Genomics 2009)
Exon-intron organization of the human multidrug-resistance protein 2 (MRP2) gene mutated in Dubin-Johnson syndrome. (PubMed id 10464142)^{1, 2, 9} Tsujii H.... Keppler D. (Gastroenterology 1999)
MRP2 haplotypes confer differential susceptibility to toxic liver injury. (PubMed id 17502832)^{1, 4, 9} Choi J.H....Lee M.G. (Pharmacogenet. Genomics 2007)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 1244	HGNC: 53	AceView: ABCC2	Ensembl:ENSG00000023839	euGenes: HUgn1244
ECgene: ABCC2	Kegg: 1244	H-InvDB: ABCC2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for ABCC2	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for ABCC2	Genetics and Cytogenetics in Oncology and Haematology
GeneReviews	http://www.ncbi.nlm.nih.gov/books/NBK1116/?term=ABCC2[genesymbol]
ABCMdb	http://abcmutations.hegelab.org/proteinDetails?uniprot_id=Q92887

Intellectual Property for ABCC2 gene
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Patent Information for ABCC2 gene:
Search GeneIP for patents involving ABCC2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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ABCC2 Gene

ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 2

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Fatty Liver
Melanoma
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bladder cancer
Retinoblastoma
Rotor Syndrome
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Cholestasis Intrahepatic
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biliary obstruction
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ABCC2 Gene

ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 2

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