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ABCC2 Gene

protein-coding GIFtS: 68

GC10P101532

ATP-binding cassette, sub-family C (CFTR/MRP), member 2
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: CMOAT)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
ABC30 ^²
CMOAT ^², ³, ⁵
CMOAT1 ^³
CMRP ^³
DJS ^¹, ²
KIAA1010 ^²
MRP2 ^¹, ², ³
OTTHUMP00000020267 ^²
cMRP ^¹, ²

Descriptions
ATP-binding cassette sub-family C member 2 ^³
ATP-binding cassette, sub-family C (CFTR/MRP), member 2 ^²
Canalicular multidrug resistance protein ^³
Multidrug resistance-associated protein 2 ^³
canalicular multispecific organic anion transporter ^²

External Ids
HGNC: 53¹
Entrez Gene: 1244²
UniProtKB: Q92887³
Ensembl: ENSG00000023839⁷

Search outside databases for aliases for ABCC2 gene

Previous GC identifers: GC10P100435 GC10P100776 GC10P101673 GC10P101207

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for ABCC2:

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC)

transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes.

ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20,

White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance.

This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in

biliary transport. Substrates include anticancer drugs such as vinblastine; therefore, this

protein appears to contribute to drug resistance in mammalian cells. Several different mutations

in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal

recessive disorder characterized by conjugated hyperbilirubinemia. [provided by RefSeq]

UniProtKB/Swiss-Prot: MRP2_HUMAN, Q92887

Function: Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular

cisplatin transporter

Gene Wiki entry for ABCC2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ABCC2 gene

Entrez Gene cytogenetic band: 10q24 Ensembl cytogenetic band: 10q24.2 HGNC cytogenetic band: 10q24

ABCC2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 10 GeneLoc Exon Structure

GeneLoc location for GC10P101532: (about GC identifiers)

Start:	101,532,493 bp from pter
End:	101,601,571 bp from pter
Size:	69,079 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000010.9 NT_030059.12

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: MRP2_HUMAN, Q92887 (See protein sequence)

Recommended Name: Canalicular multispecific organic anion transporter 1

Size: 1545 amino acids; 174191 Da

Subcellular location: Membrane; Multi-pass membrane protein

Secondary accessions: Q14022 Q5T2B1 Q92500 Q92798 Q99663 Q9UMS2

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_000383.1

ENSEMBL proteins:

ENSP00000359463 ENSP00000359478

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Sigma-Aldrich Proteins for ABCC2
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (MRP2)
	Human Recombinant Proteins from Abnova (ABCC2)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005624	membrane fraction	IEA	--
GO:0005887	integral to plasma membrane	TAS	7559771
GO:0016020	membrane	IEA	--
GO:0016324	apical plasma membrane	IEA	--
GO:0046581	intercellular canaliculus	IEA	--

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Antibodies for ABCC2:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of ABCC2
	Sigma-Aldrich Antibody Arrays and Antibodies for ABCC2
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (MRP2), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Novus Biologicals Antibodies for ABCC2

Assays for ABCC2:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q92887

ProtoNet protein and cluster: Q92887

UniProtKB/Swiss-Prot: MRP2_HUMAN, Q92887

Similarity: Belongs to the ABC transporter family. Conjugate transporter (TC 3.A.1.208) subfamily

Similarity: Contains 2 ABC transmembrane type-1 domains

Similarity: Contains 2 ABC transporter domains

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ABCC2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ABCC2)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000392

Applied Biosystems Silencer® siRNAs for ABCC2

Sigma-Aldrich siRNA and siRNA Panels for ABCC2

Sigma-Aldrich shRNA for ABCC2

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_000392
Myc/DDK tagged cDNA clone in CMV expression vector: NM_000392
untagged cDNA clone in CMV expression vector: NM_000392

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_000392

UniProtKB/Swiss-Prot: MRP2_HUMAN, Q92887

Function: Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular

cisplatin transporter

Genatlas biochemistry entry for ABCC2:

ATP binding cassette superfamily,subfamily C (CFTR/MRP),member 2,mainly expressed in canilicular

membranes of hepatocytes,also present in other apical domains of prolonged cells,such as the

epithelial cells of proximal tubule of kidney

3 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Abcc2):

homeostasis/metabolism

liver/biliary system

renal/urinary system

5/7 Gene Ontology (GO) molecular function terms (links to tree view) (see all 7 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0005215	transporter activity	IEA	--
GO:0005515	protein binding	IEA	--
GO:0005524	ATP binding	IEA	--
GO:0008514	organic anion transmembrane transporter activity	TAS	7559771

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5 Sigma-Aldrich "Your Favorite Gene" Pathways for ABCC2 (Your Favorite Gene powered by Ingenuity)

Xenobiotic Metabolism Signaling
FXR/RXR Activation
LPS/IL-1 Mediated Inhibition of RXR Function
Hepatic Cholestasis
PXR/RXR Activation

GeneDecks ABCC2 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for ABCC2

5/19 Interacting proteins for ABCC2 (ENSP00000359478³) via UniProtKB, MINT, and/or STRING (see all 19 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PDZK1	ENSP00000344147³	STRING (score=.958)
RDX	ENSP00000342830³	STRING (score=.874)
HRAS	ENSP00000373382³	STRING (score=.853)
MRPS7	ENSP00000245539³	STRING (score=.836)
ABCG2	ENSP00000237612³	STRING (score=.777)

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1 Gene Ontology (GO) biological process term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006810	transport	TAS	7559771

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for ABCC2
10/48 Novoseek chemical compound relationships for ABCC2 gene (see all 48 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
oatp	85.87	12	17724432 (3), 18327154 (1), 18838068 (1), 17906856 (1)
estradiol-17beta-glucuronide	83.88	9	18180270 (2), 11748225 (1), 18761402 (1), 14722317 (1)
gf 120918	83.58	5	18515333 (1), 16244858 (1)
androstane	79.31	8	11706036 (2), 15382119 (1), 18334180 (1), 14705863 (1) (see all 5)
s-(2,4-dinitrophenyl)glutathione	79.01	2	9794924 (1), 9525973 (1)
bilirubin monoglucuronide	76.59	6	11897625 (1), 9355767 (1), 19214140 (1), 10024515 (1)
glucuronide	64.52	17	17112804 (2), 18385448 (1), 9425227 (1), 15846474 (1) (see all 7)
rhodamine 123	62.34	4	18801307 (2), 12761814 (1)
ltc4	60.56	19	12682044 (4), 12222674 (3), 10456333 (3), 9792445 (2) (see all 7)
cmfda	60.34	8	16049127 (1), 17172311 (1), 18024096 (1)

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2 PharmGKB drug compound relationships for ABCC2 gene

Drug compound	PharmGKB Relations	PubMed IDs for articles supporting these relationships
methotrexate	PD FA	10363967 15630450
xenobiotics	FA	9377473

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ABCC2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ABCC2)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000392

Sigma-Aldrich siRNA and siRNA Panels for ABCC2

Sigma-Aldrich shRNA for ABCC2

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000392

REFSEQ mRNAs for ABCC2 gene:

NM_000392.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000392

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_000392
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_000392
                                 untagged cDNA clone in CMV expression vector: NM_000392

Additional cDNA sequence:

BC136419.1 U49248.1 U63970.1 X96395.2

8 DOTS entries:

DT.216029 DT.99999029 DT.121300501 DT.121300494 DT.216028 DT.100731911 DT.92046395 DT.121300498

24/76 AceView cDNA sequences (see all 76 ):

AV660932 AV656541 BM765259 AA699522 CA429833 BQ220800 BX643341 BF589901

AV660925 BM804774 AV652973 U63970 BP359602 AA187829 NM_000392 R02136

CD608375 AV661100 H47978 BX495933 AA931070 CB155960 BM741963 AI823554

highest scoring ESTs for ABCC2:

AA188601 AA345776 AA676255 AA677204 AA700073 AA706096 AA994962 AI272739 AV656541 AV656926

Unigene Cluster for ABCC2:

ATP-binding cassette, sub-family C (CFTR/MRP), member 2

Hs.368243 [show with all ESTs]

Unigene Representative Sequence: U49248

GeneLoc Exon Structure

2 Ensembl transcripts including schematic representations:

ENST00000370434 ENST00000370449

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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ABCC2 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ABCC2

¹ / ² / ³

2 probe-sets matching ABCC2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
206155_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_000392	0.60	1.00	0.82	1
206155_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: AACCTACTAC

SOURCE GeneReport for Unigene cluster: Hs.368243
Expression variation in blood from EXPOLDB for ABCC2
UniProtKB/Swiss-Prot: MRP2_HUMAN, Q92887
Tissue specificity: Found on the apical membrane of polarized cells in liver, kidney and intestine.
The highest expression is found in liver

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ABCC2 gene from 5/15 species (see all 15 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ABCC2¹	--	ATP-binding cassette, sub-family C (CFTR/MRP), member more	86.86(n) 83.49(a)	403632 NM_001003081.1 NP_001003081.1
chimpanzee (Pan troglodytes)	ABCC2¹	--	ATP-binding cassette, sub-family C (CFTR/MRP), member more	99.57(n) 99.29(a)	450670 XM_507976.2 XP_507976.2
cow (Bos taurus)	ABCC2¹	--	ATP-binding cassette, sub-family C (CFTR/MRP), member more	86.14(n) 81.39(a)	520925 XM_599177.3 XP_599177.3
mouse (Mus musculus)	Abcc2^{1, 5}	19 (43.00 cM)⁵	ATP-binding cassette, sub-family C (CFTR/MRP), member more^{1, 5}	80.91(n)¹ 77.76(a)¹	12780¹ NM_013806.2¹ NP_038834.2¹ AA027420⁵ AB008832⁵ (see all 11)
chicken (Gallus gallus)	ABCC2¹	--	ATP-binding cassette, sub-family C (CFTR/MRP), member more	65.54(n) 63.78(a)	423828 XM_421698.2 XP_421698.2

About this table Species with no ortholog for ABCC2

ENSEMBL Gene Tree for ABCC2

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for ABCC2 gene

ABCC3² ABCC6² ABCC1²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/466 NCBI SNPs in ABCC2 are shown (see all 466 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 144)

AB	SNP ID	Valid	Chr 10 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs2273697^1,2	A,C,F,H,O	101553805(+)	`ACACCA/GTTGGA`	1	V/I	mis¹ ese³		23	EA NA MN CSAM EU WA	3848
	rs717620^1,2	C,F,H,O	101532568(-)	`GGAACG/AAAGAC`	1	--	ut5¹ ese³		23	NA EA MN EU WA CSAM	4008
	rs927344^1,2	A,C,F,H	101534437(+)	`GGGCTT/ACCTAT`	1	Y/F	mis¹ ese³		10	MN EU EA WA	1512
--	rs1885301^1,2	A,C,F	101531043(+)	`AGTATG/ATTGTG`	1	--	ng5¹		1	--	494
--	rs7910642^1,2	A,C,F	101531569(+)	`ccaagG/Acagaa`	1	--	ng5¹		1	--	494
--	rs2804402^1,2	A,C,F	101531573(-)	`atcctT/Cctgcc`	1	--	ng5¹		1	--	494
	rs7080681^1,2	C,F,H	101550159(+)	`TGACCG/ATGACA`	1	H/R	mis¹		13	EU EA WA NA	1136
	rs8187699^1,2	C,F,H	101593621(+)	`GAATAA/GCTGAG`	1	T/A	mis¹		9	EU EA WA	1332
	rs8187710^1,2	C,F,H	101601284(+)	`AGAGTG/ACGGCA`	1	Y/C	mis¹		13	NA EU EA WA	1526
	rs8187692^1,2	C,F,H	101585965(+)	`GCAGCG/TATTTC`	1	R/L	mis¹ ese³		13	NA EU EA WA	1280

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HapMap Linkage Disequilibrium images for ABCC2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 601107 disorders: 237500

UniProtKB/Swiss-Prot: MRP2_HUMAN, Q92887

Defects in ABCC2 are the cause of Dubin-Johnson syndrome (DJS) [MIM:237500]. DJS is an

autosomal recessive disorder characterized by conjugated hyperbilirubinemia, an increase in the

urinary excretion of coproporphyrin isomer I, deposition of melanin-like pigment in hepatocytes,

and prolonged retention of sulfobromophthalein, but otherwise normal liver function

10/56 Novoseek disease relationships for ABCC2 gene (see all 56 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
dubin-johnson syndrome	95.28	75	11477083 (3), 10464142 (3), 15777714 (2), 9425227 (2) (see all 41)
hyperbilirubinemia	75.66	33	15965653 (4), 15870973 (2), 12884082 (2), 9185779 (1) (see all 19)
cholestasis	71.53	31	18700187 (3), 2035335 (3), 11481619 (2), 15057744 (2) (see all 17)
cholestasis intrahepatic	62.73	2	17997497 (2)
rotor syndrome	61.03	1	7483689 (1)
breast cancer	54.67	77	18845662 (2), 15180326 (1), 16393888 (1), 16565357 (1) (see all 48)
ovarian carcinoma	48.85	22	10767994 (5), 10537344 (4), 15262134 (3), 12216079 (2) (see all 9)
cancer	38.98	44	10427140 (3), 9398612 (3), 8797578 (1), 9270026 (1) (see all 30)
colon adenocarcinoma	38.10	2	15896333 (1), 17430634 (1)
biliary cirrhosis primary	33.31	4	16628674 (2), 14568249 (1)

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2 PharmGKB disease relationships for ABCC2 gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Leukemia, Lymphocytic, Acute, L1	PD	15630450
Spina Bifida Cystica	CO GN	15211708

About this table

Human Gene Mutation Database: ABCC2
Genetic Association Database: ABCC2
Human Genome Epidemiology Navigator: ABCC2 (54 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/571 PubMed articles for ABCC2 gene (see all 571 ):

A human canalicular multispecific organic anion transporter (cMOAT) gene is overexpressed in cisplatin-resistant human cancer cell lines with decreased drug accumulation. (PubMed id 8797578)^{1, 2, 3, 4} Taniguchi K.... Kuwano M. (1996)
Identification and functional analysis of two novel mutations in the multidrug resistance protein 2 gene in Israeli patients with Dubin- Johnson syndrome. (PubMed id 11477083)^{1, 3, 4} Mor-Cohen R....Seligsohn U. (2001)
Mutation of Trp1254 in the multispecific organic anion transporter, multidrug resistance protein 2 (MRP2) (ABCC2), alters substrate specificity and results in loss of methotrexate transport activity. (PubMed id 11500505)^{1, 3, 4} Ito K....Cole S.P.C. (2001)
Exon-intron organization of the human multidrug-resistance protein 2 (MRP2) gene mutated in Dubin-Johnson syndrome. (PubMed id 10464142)^{1, 3, 4} Tsujii H.... Keppler D. (1999)
Impaired protein maturation of the conjugate export pump multidrug resistance protein 2 as a consequence of a deletion mutation in Dubin- Johnson syndrome. (PubMed id 11093739)^{1, 3, 4} Keitel V.... Keppler D. (2000)
cDNA cloning of the hepatocyte canalicular isoform of the multidrug resistance protein, cMrp, reveals a novel conjugate export pump deficient in hyperbilirubinemic mutant rats. (PubMed id 8662992)^{1, 3, 4} Buechler M....Keppler D. (1996)
Influence of ABCB1, ABCC1, ABCC2, and ABCG2 haplotypes on the cellular exposure of nelfinavir in vivo. (PubMed id 16041239)^{1, 3, 6} Colombo S....Telenti A. (2005)
High plasma pravastatin concentrations are associated with single nucleotide polymorphisms and haplotypes of organic anion transporting polypeptide-C (OATP-C, SLCO1B1). (PubMed id 15226675)^{1, 3, 6} Niemi M....Kivisto K.T. (2004)
Hepatic secretion of conjugated drugs and endogenous substances. (PubMed id 11076395)^{1, 3, 4} Keppler D. and Koenig J. (2000)
Pharmacogenetic profiling across the irinotecan pathway in Asian patients with cancer. (PubMed id 15801936)^{1, 3, 6} Zhou Q....Chowbay B. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 1244	HGNC: 53	AceView: ABCC2	Ensembl:ENSG00000023839	euGenes: HUgn1244
ECgene: ABCC2	H-InvDB: ABCC2

(According to HUGE)
About This Section

HUGE: KIAA1010

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for ABCC2	Genetics and Cytogenetics in Oncology and Haematology
GeneReviews	http://www.genetests.org/query?gene=ABCC2

Licensable Technologies for ABCC2
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for ABCC2:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ABCC2-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ABCC2		Antibodies for ABCC2
	Explore super-pooled esiRNAs		Proteins for ABCC2
	Lentivirus-delivered shRNAs for ABCC2		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
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	Recombinant Proteins (ABCC2)
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	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

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	Recombinant Proteins (MRP2)
	Antibodies (MRP2)

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Antibodies for ABCC2

GeneCards Homepage - Last full update: 1 Jul 2009 Incremental update: 13 Oct 2009

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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ABCC2 Gene at Home site.
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ABCC2 Gene

protein-coding GIFtS: 68

Aliases &
Descriptions
for ABCC2

Summaries
for ABCC2

Genomic Location
for ABCC2

Proteins
for ABCC2

Protein Domains/
Families
for ABCC2

Gene Function
for ABCC2

Pathways & Interactions
for ABCC2

Drugs & Compounds
for ABCC2

Transcripts
for ABCC2

Expression
for ABCC2

Orthologs
for ABCC2

Paralogs
for ABCC2

SNPs/Variants
for ABCC2

Disorders & Mutations
for ABCC2

Medical News
for ABCC2

Publications
for ABCC2

Search for ABCC2

Genome Databases showing ABCC2

Other Databases showing ABCC2

Specialized Databases showing ABCC2

Licensable Technologies
for ABCC2

Services
for ABCC2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ABCC2 Gene

protein-coding GIFtS: 68

Aliases & Descriptionsfor ABCC2

Summariesfor ABCC2

Genomic Locationfor ABCC2

Proteinsfor ABCC2

Protein Domains/Familiesfor ABCC2

Gene Functionfor ABCC2

Pathways & Interactionsfor ABCC2

Drugs & Compoundsfor ABCC2

Transcriptsfor ABCC2

Expression for ABCC2

Orthologsfor ABCC2

Paralogsfor ABCC2

SNPs/Variantsfor ABCC2

Disorders & Mutationsfor ABCC2

Medical Newsfor ABCC2

Publicationsfor ABCC2

Search for ABCC2

Genome Databases showing ABCC2

Other Databases showing ABCC2

Specialized Databases showing ABCC2

Licensable Technologiesfor ABCC2

Servicesfor ABCC2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ABCC2

Summaries
for ABCC2

Genomic Location
for ABCC2

Proteins
for ABCC2

Protein Domains/
Families
for ABCC2

Gene Function
for ABCC2

Pathways & Interactions
for ABCC2

Drugs & Compounds
for ABCC2

Transcripts
for ABCC2

Expression
for ABCC2

Orthologs
for ABCC2

Paralogs
for ABCC2

SNPs/Variants
for ABCC2

Disorders & Mutations
for ABCC2

Medical News
for ABCC2

Publications
for ABCC2

Licensable Technologies
for ABCC2

Services
for ABCC2