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Aliases & Descriptions for ABCC2
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| ABC30 2 | | CMOAT 2, 3, 5 | | CMOAT1 3 | | CMRP 3 | | DJS 1, 2 | | KIAA1010 2 | | MRP2 1, 2, 3 | | OTTHUMP00000020267 2 | | cMRP 1, 2 |
| | | Descriptions |
|---|
| ATP-binding cassette sub-family C member 2 3 | | ATP-binding cassette, sub-family C (CFTR/MRP), member 2 2 | | Canalicular multidrug resistance protein 3 | | Multidrug resistance-associated protein 2 3 | | canalicular multispecific organic anion transporter 2 |
|
| | Search outside databases for aliases for ABCC2 genePrevious GC identifers: GC10P100435 GC10P100776 GC10P101673 GC10P101207 |
Summaries for ABCC2(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for ABCC2: The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine; therefore, this protein appears to contribute to drug resistance in mammalian cells. Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia. [provided by RefSeq] UniProtKB/Swiss-Prot: MRP2_HUMAN, Q92887Function: Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporterGene Wiki entry for ABCC2 |
Genomic Location for ABCC2
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the ABCC2 gene 
Entrez Gene cytogenetic band: 10q24 Ensembl cytogenetic band: 10q24.2 HGNC cytogenetic band: 10q24ABCC2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 10 GeneLoc Exon Structure GeneLoc location for GC10P101532:
(about GC identifiers)
Start:
|
101,532,493 bp from pter |
End:
|
101,601,571 bp from pter |
Size:
|
69,079 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000010.9 NT_030059.12
| Proteins for ABCC2
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: MRP2_HUMAN, Q92887 (See
protein sequence)Recommended Name: Canalicular multispecific organic anion transporter 1 Size: 1545 amino acids; 174191 Da
Subcellular location: Membrane; Multi-pass membrane protein
Secondary accessions: Q14022 Q5T2B1 Q92500 Q92798 Q99663 Q9UMS2Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_000383.1
ENSEMBL proteins: ENSP00000359463 ENSP00000359478
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
5 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for ABCC2: Assays for ABCC2: | Protein
Domains/ Families for ABCC2(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q92887
ProtoNet protein and cluster: Q92887 UniProtKB/Swiss-Prot: MRP2_HUMAN, Q92887Similarity: Belongs to the ABC transporter family. Conjugate transporter (TC 3.A.1.208) subfamilySimilarity: Contains 2 ABC transmembrane type-1 domainsSimilarity: Contains 2 ABC transporter domains | Gene Function for ABCC2
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000392
Applied Biosystems Silencer® siRNAs for ABCC2
Sigma-Aldrich siRNA and siRNA Panels for ABCC2  Sigma-Aldrich shRNA for ABCC2  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_000392                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_000392                                  untagged cDNA clone in CMV expression vector: NM_000392 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_000392
UniProtKB/Swiss-Prot: MRP2_HUMAN, Q92887Function: Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporterGenatlas biochemistry entry for ABCC2:ATP binding cassette superfamily,subfamily C (CFTR/MRP),member 2,mainly expressed in canilicular membranes of hepatocytes,also present in other apical domains of prolonged cells,such as the epithelial cells of proximal tubule of kidney3 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Abcc2):
5/7 Gene Ontology (GO) molecular function terms (links to tree view) (see all 7
): About this table | Pathways & Interactions for ABCC2
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| 5 Sigma-Aldrich "Your Favorite Gene" Pathways for ABCC2 (Your Favorite Gene powered by Ingenuity) 
Gene Network CentralTM Interacting Genes and Proteins Network for ABCC2 
5/19 Interacting proteins for ABCC2 (ENSP000003594783) via UniProtKB, MINT, and/or STRING (see all 19
)About this table
1 Gene Ontology (GO) biological process term (links to tree view): About this table
|
Drugs & Compounds for ABCC2(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for ABCC2 10/48 Novoseek chemical compound relationships for ABCC2 gene (see all 48
)
| Compound |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| oatp |
85.87 |
12 |
17724432 (3), 18327154 (1), 18838068 (1), 17906856 (1) |
| estradiol-17beta-glucuronide |
83.88 |
9 |
18180270 (2), 11748225 (1), 18761402 (1), 14722317 (1) |
| gf 120918 |
83.58 |
5 |
18515333 (1), 16244858 (1) |
| androstane |
79.31 |
8 |
11706036 (2), 15382119 (1), 18334180 (1), 14705863 (1) (see all 5) |
| s-(2,4-dinitrophenyl)glutathione |
79.01 |
2 |
9794924 (1), 9525973 (1) |
| bilirubin monoglucuronide |
76.59 |
6 |
11897625 (1), 9355767 (1), 19214140 (1), 10024515 (1) |
| glucuronide |
64.52 |
17 |
17112804 (2), 18385448 (1), 9425227 (1), 15846474 (1) (see all 7) |
| rhodamine 123 |
62.34 |
4 |
18801307 (2), 12761814 (1) |
| ltc4 |
60.56 |
19 |
12682044 (4), 12222674 (3), 10456333 (3), 9792445 (2) (see all 7) |
| cmfda |
60.34 |
8 |
16049127 (1), 17172311 (1), 18024096 (1) |
About this table
2 PharmGKB drug compound relationships for ABCC2 geneAbout this table
|
Transcripts for ABCC2(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000392
Sigma-Aldrich siRNA and siRNA Panels for ABCC2  Sigma-Aldrich shRNA for ABCC2  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_000392 REFSEQ mRNAs for ABCC2 gene: NM_000392.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_000392               OriGene GFP tagged cDNA clone in CMV expression vector: NM_000392                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_000392                                  untagged cDNA clone in CMV expression vector: NM_000392  Additional cDNA sequence: BC136419.1 U49248.1 U63970.1 X96395.2 8 DOTS entries: DT.216029 DT.99999029 DT.121300501 DT.121300494 DT.216028 DT.100731911 DT.92046395 DT.121300498 24/76 AceView cDNA sequences (see all 76
):AV660932 AV656541 BM765259 AA699522 CA429833 BQ220800 BX643341 BF589901 AV660925 BM804774 AV652973 U63970 BP359602 AA187829 NM_000392 R02136 CD608375 AV661100 H47978 BX495933 AA931070 CB155960 BM741963 AI823554
highest scoring ESTs for ABCC2:AA188601 AA345776 AA676255 AA677204 AA700073 AA706096 AA994962 AI272739 AV656541 AV656926 Unigene Cluster for ABCC2: ATP-binding cassette, sub-family C (CFTR/MRP), member 2 Hs.368243 [show with all ESTs]Unigene Representative Sequence: U49248
GeneLoc Exon Structure
2 Ensembl transcripts including schematic representations: ENST00000370434
ENST00000370449
|
Expression for ABCC2
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| ABCC2 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for ABCC2
1 / 2 / 3 2 probe-sets matching ABCC2 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: AACCTACTAC
SOURCE GeneReport for Unigene cluster: Hs.368243
Expression variation in blood from EXPOLDB for ABCC2 UniProtKB/Swiss-Prot: MRP2_HUMAN, Q92887Tissue specificity: Found on the apical membrane of polarized cells in liver, kidney and intestine. The highest expression is found in liver |
Orthologs for ABCC2
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for ABCC2 gene from 5/15 species (see all 15
)
| Organism |
Gene |
Locus |
Description |
Human Similarity |
NCBI accessions |
dog (Canis familiaris) |
ABCC21 |
-- |
ATP-binding cassette, sub-family C (CFTR/MRP), member more |
86.86(n) 83.49(a) |
403632 NM_001003081.1 NP_001003081.1 |
chimpanzee (Pan troglodytes) |
ABCC21 |
-- |
ATP-binding cassette, sub-family C (CFTR/MRP), member more |
99.57(n) 99.29(a) |
450670 XM_507976.2 XP_507976.2 |
cow (Bos taurus) |
ABCC21 |
-- |
ATP-binding cassette, sub-family C (CFTR/MRP), member more |
86.14(n) 81.39(a) |
520925 XM_599177.3 XP_599177.3 |
mouse (Mus musculus) |
Abcc21, 5 |
19 (43.00 cM)5
|
ATP-binding cassette, sub-family C (CFTR/MRP), member more1, 5 |
80.91(n)1 77.76(a)1 |
127801 NM_013806.21 NP_038834.21 AA0274205 AB0088325 (see all 11) |
chicken (Gallus gallus) |
ABCC21 |
-- |
ATP-binding cassette, sub-family C (CFTR/MRP), member more |
65.54(n) 63.78(a) |
423828 XM_421698.2 XP_421698.2 |
About this table Species with no ortholog for ABCC2
ENSEMBL Gene Tree for ABCC2 | Paralogs for ABCC2(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for ABCC2 gene
- ABCC32 ABCC62 ABCC12
|
SNPs/Variants for ABCC2(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for ABCC2 (up to first 250kb)
|
Disorders & Mutations for ABCC2
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 601107 disorders: 237500 UniProtKB/Swiss-Prot: MRP2_HUMAN, Q92887
Defects in ABCC2 are the cause of Dubin-Johnson syndrome (DJS) [MIM:237500]. DJS is an autosomal recessive disorder characterized by conjugated hyperbilirubinemia, an increase in the urinary excretion of coproporphyrin isomer I, deposition of melanin-like pigment in hepatocytes, and prolonged retention of sulfobromophthalein, but otherwise normal liver function10/56 Novoseek disease relationships for ABCC2 gene (see all 56
)
| Disease |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| dubin-johnson syndrome |
95.28 |
75 |
11477083 (3), 10464142 (3), 15777714 (2), 9425227 (2) (see all 41) |
| hyperbilirubinemia |
75.66 |
33 |
15965653 (4), 15870973 (2), 12884082 (2), 9185779 (1) (see all 19) |
| cholestasis |
71.53 |
31 |
18700187 (3), 2035335 (3), 11481619 (2), 15057744 (2) (see all 17) |
| cholestasis intrahepatic |
62.73 |
2 |
17997497 (2) |
| rotor syndrome |
61.03 |
1 |
7483689 (1) |
| breast cancer |
54.67 |
77 |
18845662 (2), 15180326 (1), 16393888 (1), 16565357 (1) (see all 48) |
| ovarian carcinoma |
48.85 |
22 |
10767994 (5), 10537344 (4), 15262134 (3), 12216079 (2) (see all 9) |
| cancer |
38.98 |
44 |
10427140 (3), 9398612 (3), 8797578 (1), 9270026 (1) (see all 30) |
| colon adenocarcinoma |
38.10 |
2 |
15896333 (1), 17430634 (1) |
| biliary cirrhosis primary |
33.31 |
4 |
16628674 (2), 14568249 (1) |
About this table
2 PharmGKB disease relationships for ABCC2 geneAbout this table
Human Gene Mutation Database: ABCC2 Genetic Association Database: ABCC2 Human Genome Epidemiology Navigator: ABCC2 (54 documents)
|
Medical News for ABCC2(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for ABCC2 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/571 PubMed articles for ABCC2 gene (see all 571
):- A human canalicular multispecific organic anion transporter (cMOAT) gene is overexpressed in cisplatin-resistant human cancer cell lines with decreased drug accumulation. (PubMed id 8797578)1, 2, 3, 4 Taniguchi K.... Kuwano M. (1996)
- Identification and functional analysis of two novel mutations in the multidrug resistance protein 2 gene in Israeli patients with Dubin- Johnson syndrome. (PubMed id 11477083)1, 3, 4 Mor-Cohen R....Seligsohn U. (2001)
- Mutation of Trp1254 in the multispecific organic anion transporter, multidrug resistance protein 2 (MRP2) (ABCC2), alters substrate specificity and results in loss of methotrexate transport activity. (PubMed id 11500505)1, 3, 4 Ito K....Cole S.P.C. (2001)
- Exon-intron organization of the human multidrug-resistance protein 2 (MRP2) gene mutated in Dubin-Johnson syndrome. (PubMed id 10464142)1, 3, 4 Tsujii H.... Keppler D. (1999)
- Impaired protein maturation of the conjugate export pump multidrug resistance protein 2 as a consequence of a deletion mutation in Dubin- Johnson syndrome. (PubMed id 11093739)1, 3, 4 Keitel V.... Keppler D. (2000)
- cDNA cloning of the hepatocyte canalicular isoform of the multidrug resistance protein, cMrp, reveals a novel conjugate export pump deficient in hyperbilirubinemic mutant rats. (PubMed id 8662992)1, 3, 4 Buechler M....Keppler D. (1996)
- Influence of ABCB1, ABCC1, ABCC2, and ABCG2 haplotypes on the cellular exposure of nelfinavir in vivo. (PubMed id 16041239)1, 3, 6 Colombo S....Telenti A. (2005)
- High plasma pravastatin concentrations are associated with single nucleotide polymorphisms and haplotypes of organic anion transporting polypeptide-C (OATP-C, SLCO1B1). (PubMed id 15226675)1, 3, 6 Niemi M....Kivisto K.T. (2004)
- Hepatic secretion of conjugated drugs and endogenous substances. (PubMed id 11076395)1, 3, 4 Keppler D. and Koenig J. (2000)
- Pharmacogenetic profiling across the irinotecan pathway in Asian patients with cancer. (PubMed id 15801936)1, 3, 6 Zhou Q....Chowbay B. (2005)
|
Search for ABCC2
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing ABCC2
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing ABCC2
(According to HUGE)
About This Section
| |
Specialized Databases showing ABCC2(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for ABCC2(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
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 Products for ABCC2:

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