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ABCC2 Gene(Protein Coding)

ATP Binding Cassette Subfamily C Member 2

GCID:
GC10P099782
GIFtS:
70
Genes Participants
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Aliases for ABCC2 Gene

Aliases for ABCC2 Gene

  • ATP Binding Cassette Subfamily C Member 2 2 3 5
  • ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 2 2 3
  • Multidrug Resistance-Associated Protein 2 3 4
  • Canalicular Multidrug Resistance Protein 3 4
  • CMOAT 3 4
  • CMRP 3 4
  • MRP2 3 4
  • Canalicular Multispecific Organic Anion Transporter 1 2
  • ATP-Binding Cassette Sub-Family C Member 2 4
  • CMOAT1 4
  • ABC30 3
  • DJS 3

External Ids for ABCC2 Gene

Previous HGNC Symbols for ABCC2 Gene

  • CMOAT

Previous GeneCards Identifiers for ABCC2 Gene

  • GC10P100435
  • GC10P100776
  • GC10P101673
  • GC10P101207
  • GC10P101532
  • GC10P095169

Summaries for ABCC2 Gene

Entrez Gene Summary for ABCC2 Gene

  • The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine; therefore, this protein appears to contribute to drug resistance in mammalian cells. Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia. [provided by RefSeq, Jul 2008]

GeneCards Summary for ABCC2 Gene

ABCC2 (ATP Binding Cassette Subfamily C Member 2) is a Protein Coding gene. Diseases associated with ABCC2 include Dubin-Johnson Syndrome and Abcc2-Related Altered Drug Metabolism. Among its related pathways are Statin Pathway - Generalized, Pharmacokinetics and Phenytoin Pathway, Pharmacokinetics. GO annotations related to this gene include transporter activity and protein domain specific binding. An important paralog of this gene is ABCC3.

UniProtKB/Swiss-Prot for ABCC2 Gene

  • Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporter.

Gene Wiki entry for ABCC2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ABCC2 Gene

Genomics for ABCC2 Gene

Products:

  1. Regulatory Element

Regulatory Elements for ABCC2 Gene

Enhancers for ABCC2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ABCC2 on UCSC Golden Path with GeneCards custom track

Promoters for ABCC2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ABCC2 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the ABCC2 gene promoter:

Genomic Location for ABCC2 Gene

Chromosome:
10
Start:
99,782,598 bp from pter
End:
99,852,576 bp from pter
Size:
69,979 bases
Orientation:
Plus strand

Genomic View for ABCC2 Gene

Genes around ABCC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ABCC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ABCC2 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for ABCC2 Gene

Proteins for ABCC2 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for ABCC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92887-MRP2_HUMAN
    Recommended name:
    Canalicular multispecific organic anion transporter 1
    Protein Accession:
    Q92887
    Secondary Accessions:
    • B2RMT8
    • Q14022
    • Q5T2B1
    • Q92500
    • Q92798
    • Q99663
    • Q9UMS2

    Protein attributes for ABCC2 Gene

    Size:
    1545 amino acids
    Molecular mass:
    174207 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ABCC2 Gene

Proteomics data for ABCC2 Gene at MOPED

Protein Expression for ABCC2 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for ABCC2 Gene

  • Glycosylation at Asn 7, Asn 12, and Asn 1011
  • Modification sites at PhosphoSitePlus

Other Protein References for ABCC2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for ABCC2 (ABCC2)
  • Abcam antibodies for MRP2

No data available for DME Specific Peptides for ABCC2 Gene

Domains & Families for ABCC2 Gene

Gene Families for ABCC2 Gene

HGNC:
IUPHAR :

Protein Domains for ABCC2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ABCC2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q92887

UniProtKB/Swiss-Prot:

MRP2_HUMAN :
  • Contains 2 ABC transmembrane type-1 domains.
  • Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
Domain:
  • Contains 2 ABC transmembrane type-1 domains.
  • Contains 2 ABC transporter domains.
Family:
  • Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
genes like me logo Genes that share domains with ABCC2: view

Function for ABCC2 Gene

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  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for ABCC2 Gene

GENATLAS Biochemistry:
ATP binding cassette superfamily,subfamily C (CFTR/MRP),member 2,mainly expressed in canilicular membranes of hepatocytes,also present in other apical domains of prolonged cells,such as the epithelial cells of proximal tubule of kidney
UniProtKB/Swiss-Prot Function:
Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporter.

Gene Ontology (GO) - Molecular Function for ABCC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019904 protein domain specific binding IEA --
genes like me logo Genes that share ontologies with ABCC2: view

Phenotypes for ABCC2 Gene

MGI mutant phenotypes for ABCC2:
inferred from 4 alleles
GenomeRNAi human phenotypes for ABCC2:
genes like me logo Genes that share phenotypes with ABCC2: view

Human Phenotype Ontology for ABCC2 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for ABCC2 Gene

MGI Knock Outs for ABCC2:

Animal Model Products

  • Taconic Biosciences Mouse Models for ABCC2

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targets and HOMER Transcription for ABCC2 Gene

Localization for ABCC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ABCC2 Gene

Apical cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ABCC2 Gene COMPARTMENTS Subcellular localization image for ABCC2 gene
Compartment Confidence
plasma membrane 5
nucleus 2
cytoskeleton 1
cytosol 1
extracellular 1
vacuole 1

Gene Ontology (GO) - Cellular Components for ABCC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with ABCC2: view

Pathways & Interactions for ABCC2 Gene

genes like me logo Genes that share pathways with ABCC2: view

Gene Ontology (GO) - Biological Process for ABCC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006979 response to oxidative stress IEA --
GO:0008152 metabolic process IEA --
GO:0009408 response to heat IEA --
GO:0015732 prostaglandin transport IEA --
GO:0031427 response to methotrexate IEA --
genes like me logo Genes that share ontologies with ABCC2: view

No data available for SIGNOR curated interactions for ABCC2 Gene

Drugs & Compounds for ABCC2 Gene

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  1. Drug

(156) Drugs for ABCC2 Gene - From: DrugBank, PharmGKB, DGIdb, FDA Approved Drugs, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Docetaxel Approved May 1996, Investigational Pharma Transporter, substrate Microtubulin disassembly inhibitor, Tubulin and VEGF inhibitor, Taxanes 1859
Methotrexate Approved Pharma Transporter, substrate, inhibitor Folate antagonist,inhibits DFHR, Cytotoxic agent 1466
Pravastatin Approved Pharma Competitive, Inhibitor, Transporter, substrate, inhibitor 145
Ritonavir Approved, Investigational Pharma Transporter, substrate, inducer HIV protease inhibitor 853
Sulfinpyrazone Approved Pharma modulator, Target, Transporter, inhibitor, substrate 0

(58) Additional Compounds for ABCC2 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
3',4'-Dihydrodiol
O-Desmethylverapamil (D-702)
genes like me logo Genes that share compounds with ABCC2: view

Transcripts for ABCC2 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for ABCC2 Gene

(4) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(76) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ABCC2 Gene

ATP-binding cassette, sub-family C (CFTR/MRP), member 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ABCC2 Gene

No ASD Table

Relevant External Links for ABCC2 Gene

GeneLoc Exon Structure for
ABCC2
ECgene alternative splicing isoforms for
ABCC2

Expression for ABCC2 Gene

Products:

  1. Primer

mRNA expression in normal human tissues for ABCC2 Gene

mRNA expression in normal human tissues for ABCC2 Gene
mRNA expression by BioGPS for ABCC2 GenemRNA expression by GTEx for ABCC2 Gene

mRNA differential expression in normal tissues according to GTEx for ABCC2 Gene

This gene is overexpressed in Liver (x33.3) and Kidney - Cortex (x4.4).

Protein differential expression in normal tissues from HIPED for ABCC2 Gene

This gene is overexpressed in Oral epithelium (25.5), Liver (17.0), and Plasma (14.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ABCC2 Gene



SOURCE GeneReport for Unigene cluster for ABCC2 Gene Hs.368243

mRNA Expression by UniProt/SwissProt for ABCC2 Gene

Q92887-MRP2_HUMAN
Tissue specificity: Expressed by polarized cells in liver, kidney and intestine. The highest expression is found in liver.
genes like me logo Genes that share expression patterns with ABCC2: view

Protein tissue co-expression partners for ABCC2 Gene

Primer Products

Orthologs for ABCC2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ABCC2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
 Mammalia ABCC2 35
  • 86.09 (n)
  • 81.64 (a)
ABCC2 36
  • 80 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia ABCC2 35
  • 86.86 (n)
  • 83.49 (a)
MRP2 36
  • 83 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Abcc2 35
  • 80.9 (n)
  • 77.71 (a)
Abcc2 16
Abcc2 36
  • 78 (a)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Abcc2 35
  • 81.16 (n)
  • 77.81 (a)
oppossum
(Monodelphis domestica)
 Mammalia ABCC2 36
  • 63 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia ABCC2 36
  • 66 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves ABCC2 35
  • 65.47 (n)
  • 63.52 (a)
ABCC2 36
  • 62 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia ABCC2 36
  • 64 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia abcc2 35
  • 64.17 (n)
  • 63.43 (a)
zebrafish
(Danio rerio)
 Actinopterygii abcc2 35
  • 60.73 (n)
  • 59.1 (a)
zgc66072 35
abcc2 36
  • 56 (a)
 OneToOne
fruit fly
(Drosophila melanogaster)
 Insecta CG6214 37
  • 43 (a)
Sur 37
  • 46 (a)
MRP 36
  • 45 (a)
 ManyToMany
worm
(Caenorhabditis elegans)
 Secernentea mrp-2 37
  • 41 (a)
mrp-7 37
  • 34 (a)
mrp-8 37
  • 40 (a)
mrp-3 36
  • 37 (a)
 ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes YCF1 36
  • 37 (a)
 OneToMany
NFT1 38
thale cress
(Arabidopsis thaliana)
 eudicotyledons MRP1 35
  • 50.33 (n)
  • 42.88 (a)
wheat
(Triticum aestivum)
 Liliopsida Ta.9148 35
sea squirt
(Ciona savignyi)
 Ascidiacea -- 36
  • 46 (a)
 ManyToMany
Species with no ortholog for ABCC2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for ABCC2 Gene

ENSEMBL:
Gene Tree for ABCC2 (if available)
TreeFam:
Gene Tree for ABCC2 (if available)

Paralogs for ABCC2 Gene

Paralogs for ABCC2 Gene

(20) SIMAP similar genes for ABCC2 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for ABCC2 Gene

genes like me logo Genes that share paralogs with ABCC2: view

Variants for ABCC2 Gene

Sequence variations from dbSNP and Humsavar for ABCC2 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs56199535 Dubin-Johnson syndrome (DJS) 99,818,820(+) AGCAG(A/C/G/T)GGATC nc-transcript-variant, reference, missense
VAR_010756 Dubin-Johnson syndrome (DJS)
rs56131651 - 99,797,306(+) TCAGA(A/G)TCAAA nc-transcript-variant, reference, missense
rs2273697 - 99,804,058(+) ACACC(A/G)TTGGA nc-transcript-variant, reference, missense
rs56220353 - 99,818,884(+) CCTGT(C/G/T)TGCAG nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for ABCC2 Gene

Variant ID Type Subtype PubMed ID
dgv805n71 CNV Loss 21882294
nsv895917 CNV Loss 21882294
nsv895918 CNV Loss 21882294
nsv825539 CNV Loss 20364138
nsv825540 CNV Gain 20364138
nsv831960 CNV Gain 17160897
nsv895921 CNV Loss 21882294

Variation tolerance for ABCC2 Gene

Residual Variation Intolerance Score: 86.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.72; 78.70% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ABCC2 Gene

Human Gene Mutation Database (HGMD)
ABCC2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ABCC2 Gene

Disorders for ABCC2 Gene

MalaCards: The human disease database

(14) MalaCards diseases for ABCC2 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
dubin-johnson syndrome
  • chronic idiopathic jaundice
abcc2-related altered drug metabolism
  • multidrug resistance associated protein 2
bilirubin metabolic disorder
  • hereditary hyperbilirubinemia
cholestasis
  • bile occlusion
intrahepatic cholestasis
  • intrahepatic cholestasis of pregnancy
- elite association - COSMIC cancer census association via MalaCards
Search ABCC2 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

MRP2_HUMAN
  • Dubin-Johnson syndrome (DJS) [MIM:237500]: Autosomal recessive disorder characterized by conjugated hyperbilirubinemia, an increase in the urinary excretion of coproporphyrin isomer I, deposition of melanin-like pigment in hepatocytes, and prolonged retention of sulfobromophthalein, but otherwise normal liver function. {ECO:0000269 PubMed:10053008, ECO:0000269 PubMed:10464142, ECO:0000269 PubMed:11266082, ECO:0000269 PubMed:11477083, ECO:0000269 PubMed:25336012, ECO:0000269 PubMed:9425227}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for ABCC2

Genetic Association Database (GAD)
ABCC2
Human Genome Epidemiology (HuGE) Navigator
ABCC2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ABCC2
genes like me logo Genes that share disorders with ABCC2: view

No data available for Genatlas for ABCC2 Gene

Publications for ABCC2 Gene

  1. A human canalicular multispecific organic anion transporter (cMOAT) gene is overexpressed in cisplatin-resistant human cancer cell lines with decreased drug accumulation. (PMID: 8797578) Taniguchi K. … Kuwano M. (Cancer Res. 1996) 2 3 4 23 67
  2. Evidence for two interacting ligand binding sites in human multidrug resistance protein 2 (ATP binding cassette C2). (PMID: 12702717) Zelcer N. … Borst P. (J. Biol. Chem. 2003) 3 23 25 26
  3. Mutation of Trp1254 in the multispecific organic anion transporter, multidrug resistance protein 2 (MRP2) (ABCC2), alters substrate specificity and results in loss of methotrexate transport activity. (PMID: 11500505) Ito K. … Cole S.P.C. (J. Biol. Chem. 2001) 3 23 25 26
  4. Interaction of angiotensin receptor type 1 blockers with ATP-binding cassette transporters. (PMID: 20222053) Weiss J. … Benndorf R.A. (Biopharm Drug Dispos 2010) 23 25 26
  5. Small intestinal efflux mediated by MRP2 and BCRP shifts sulfasalazine intestinal permeability from high to low, enabling its colonic targeting. (PMID: 19541926) Dahan A. … Amidon G.L. (Am. J. Physiol. Gastrointest. Liver Physiol. 2009) 3 25 26

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