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Aliases for ABCC2 Gene

Aliases for ABCC2 Gene

  • ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 2 2 3
  • CMOAT 3 4 6
  • Canalicular Multispecific Organic Anion Transporter 1 2 3
  • Multidrug Resistance-Associated Protein 2 3 4
  • Canalicular Multidrug Resistance Protein 3 4
  • MRP2 3 4
  • CMRP 3 4
  • ATP-Binding Cassette Sub-Family C Member 2 4
  • CMOAT1 4
  • ABC30 3
  • DJS 3

External Ids for ABCC2 Gene

Previous Symbols for ABCC2 Gene

  • CMOAT

Summaries for ABCC2 Gene

Entrez Gene Summary for ABCC2 Gene

  • The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine; therefore, this protein appears to contribute to drug resistance in mammalian cells. Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia. [provided by RefSeq, Jul 2008]

GeneCards Summary for ABCC2 Gene

ABCC2 (ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 2) is a Protein Coding gene. Diseases associated with ABCC2 include dubin-johnson syndrome and dysembryoplastic neuroepithelial tumor. Among its related pathways are Glucose / Energy Metabolism and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include protein domain specific binding and organic anion transmembrane transporter activity. An important paralog of this gene is ABCC5.

UniProtKB/Swiss-Prot for ABCC2 Gene

  • Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporter

Gene Wiki entry for ABCC2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ABCC2 Gene

Genomics for ABCC2 Gene

Genomic Location for ABCC2 Gene

Start:
99,782,694 bp from pter
End:
99,852,192 bp from pter
Size:
69,499 bases
Orientation:
Plus strand

Genomic View for ABCC2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ABCC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ABCC2 Gene

Regulatory Elements for ABCC2 Gene

Proteins for ABCC2 Gene

  • Protein details for ABCC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92887-MRP2_HUMAN
    Recommended name:
    Canalicular multispecific organic anion transporter 1
    Protein Accession:
    Q92887
    Secondary Accessions:
    • B2RMT8
    • Q14022
    • Q5T2B1
    • Q92500
    • Q92798
    • Q99663
    • Q9UMS2

    Protein attributes for ABCC2 Gene

    Size:
    1545 amino acids
    Molecular mass:
    174207 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ABCC2 Gene

Proteomics data for ABCC2 Gene at MOPED

Post-translational modifications for ABCC2 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn7, Asn12, and Asn1011

Other Protein References for ABCC2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for ABCC2 Gene

Domains for ABCC2 Gene

Gene Families for ABCC2 Gene

HGNC:
  • ABCC :ATP binding cassette transporters / subfamily C
IUPHAR :

UniProtKB/Swiss-Prot:

MRP2_HUMAN
Domain:
  • Contains 2 ABC transmembrane type-1 domains.:
    • Q92887
  • Contains 2 ABC transporter domains.:
    • Q92887
Family:
  • Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.:
    • Q92887
genes like me logo Genes that share domains with ABCC2: view

Function for ABCC2 Gene

Molecular function for ABCC2 Gene

GENATLAS Biochemistry: ATP binding cassette superfamily,subfamily C (CFTR/MRP),member 2,mainly expressed in canilicular membranes of hepatocytes,also present in other apical domains of prolonged cells,such as the epithelial cells of proximal tubule of kidney
UniProtKB/Swiss-Prot Function: Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporter

Gene Ontology (GO) - Molecular Function for ABCC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity --
GO:0005515 protein binding IPI 21988832
GO:0005524 ATP binding IEA --
GO:0008514 organic anion transmembrane transporter activity IEA --
GO:0016887 ATPase activity --
genes like me logo Genes that share ontologies with ABCC2: view
genes like me logo Genes that share phenotypes with ABCC2: view

Animal Models for ABCC2 Gene

MGI Knock Outs for ABCC2:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for ABCC2 Gene

Localization for ABCC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ABCC2 Gene

Apical cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ABCC2 Gene COMPARTMENTS Subcellular localization image for ABCC2 gene
Compartment Confidence
plasma membrane 4
nucleus 2
cytoskeleton 1
extracellular 1

Gene Ontology (GO) - Cellular Components for ABCC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IEA --
GO:0009986 cell surface IDA 19581412
GO:0016020 membrane --
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with ABCC2: view

Pathways for ABCC2 Gene

genes like me logo Genes that share pathways with ABCC2: view

Gene Ontology (GO) - Biological Process for ABCC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006200 obsolete ATP catabolic process --
GO:0006810 transport TAS 7559771
GO:0006855 drug transmembrane transport IEA --
GO:0006979 response to oxidative stress IEA --
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with ABCC2: view

Compounds for ABCC2 Gene

(2) HMDB Compounds for ABCC2 Gene

Compound Synonyms Cas Number PubMed IDs
Bilirubin
  • (4Z,15Z)-Bilirubin IXa
635-65-4
Pravastatin
  • 3beta-Hydroxycompactin
81093-37-0

(77) Drugbank Compounds for ABCC2 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
(1,10 Phenanthroline)-(Tri-Carbon Monoxide) Rhenium (I)
transporter inhibitor
5-methyltetrahydrofolate
  • [(6S)-5-methyl-5,6,7,8-tetrahydropteroyl]glutamate
134-35-0 transporter inhibitor
Adenosine triphosphate
  • 5'-ATP
56-65-5 target
Aminohippurate
  • Aminohippurate Sodium
94-16-6 transporter substrate inhibitor
Arsenic trioxide
  • Acide Arsenieux [French]
1327-53-3 transporter inducer

(146) Novoseek inferred chemical compound relationships for ABCC2 Gene

Compound -log(P) Hits PubMed IDs
mk 571 90.7 10
oatp 86.7 8
gf 120918 85.6 3
estradiol-17beta-glucuronide 83.7 6
probenecid 79.5 19

(16) PharmGKB related drug/compound annotations for ABCC2 Gene

genes like me logo Genes that share compounds with ABCC2: view

Transcripts for ABCC2 Gene

Unigene Clusters for ABCC2 Gene

ATP-binding cassette, sub-family C (CFTR/MRP), member 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ABCC2 Gene

No ASD Table

Relevant External Links for ABCC2 Gene

GeneLoc Exon Structure for
ABCC2
ECgene alternative splicing isoforms for
ABCC2

Expression for ABCC2 Gene

mRNA expression in normal human tissues for ABCC2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ABCC2 Gene

This gene is overexpressed in Liver (33.3) and Kidney - Cortex (4.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ABCC2 Gene

SOURCE GeneReport for Unigene cluster for ABCC2 Gene Hs.368243

mRNA Expression by UniProt/SwissProt for ABCC2 Gene

Q92887-MRP2_HUMAN
Tissue specificity: Expressed by polarized cells in liver, kidney and intestine. The highest expression is found in liver
genes like me logo Genes that share expressions with ABCC2: view

Orthologs for ABCC2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ABCC2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ABCC2 36
  • 86.09 (n)
  • 81.64 (a)
ABCC2 37
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ABCC2 36
  • 86.86 (n)
  • 83.49 (a)
MRP2 37
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Abcc2 36
  • 80.9 (n)
  • 77.71 (a)
Abcc2 16
Abcc2 37
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ABCC2 37
  • 63 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ABCC2 37
  • 66 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Abcc2 36
  • 81.16 (n)
  • 77.81 (a)
chicken
(Gallus gallus)
Aves ABCC2 36
  • 65.47 (n)
  • 63.52 (a)
ABCC2 37
  • 62 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ABCC2 37
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia abcc2 36
  • 64.17 (n)
  • 63.43 (a)
zebrafish
(Danio rerio)
Actinopterygii abcc2 36
  • 60.73 (n)
  • 59.1 (a)
abcc2 37
  • 56 (a)
OneToOne
zgc66072 36
fruit fly
(Drosophila melanogaster)
Insecta MRP 37
  • 45 (a)
ManyToMany
Sur 38
  • 46 (a)
CG6214 38
  • 43 (a)
worm
(Caenorhabditis elegans)
Secernentea mrp-3 37
  • 37 (a)
ManyToMany
mrp-7 38
  • 34 (a)
mrp-8 38
  • 40 (a)
mrp-2 38
  • 41 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NFT1 39
YCF1 37
  • 37 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons MRP1 36
  • 50.33 (n)
  • 42.88 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.9148 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 46 (a)
ManyToMany
Species with no ortholog for ABCC2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for ABCC2 Gene

ENSEMBL:
Gene Tree for ABCC2 (if available)
TreeFam:
Gene Tree for ABCC2 (if available)

Paralogs for ABCC2 Gene

Paralogs for ABCC2 Gene

Selected SIMAP similar genes for ABCC2 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for ABCC2 Gene

genes like me logo Genes that share paralogs with ABCC2: view

Variants for ABCC2 Gene

Sequence variations from dbSNP and Humsavar for ABCC2 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs12826 -- 99,852,563(-) agaac(A/G)agctt downstream-variant-500B
rs717620 -- 99,782,821(-) GGAAC(A/G)AAGAC utr-variant-5-prime
rs927344 - 99,784,690(+) GGGCT(A/T)CCTAT reference, missense
rs1137968 -- 99,847,104(+) GAAGT(G/T)ACAGA reference, synonymous-codon
rs1885301 -- 99,781,296(+) AGTAT(A/G)TTGTG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ABCC2 Gene

Variant ID Type Subtype PubMed ID
dgv805n71 CNV Loss 21882294
nsv895917 CNV Loss 21882294
nsv895918 CNV Loss 21882294
nsv825539 CNV Loss 20364138
nsv825540 CNV Gain 20364138
nsv831960 CNV Gain 17160897
nsv895921 CNV Loss 21882294

Relevant External Links for ABCC2 Gene

HapMap Linkage Disequilibrium report
ABCC2
Human Gene Mutation Database (HGMD)
ABCC2

Disorders for ABCC2 Gene

(1) OMIM Diseases for ABCC2 Gene (601107)

UniProtKB/Swiss-Prot

MRP2_HUMAN
  • Dubin-Johnson syndrome (DJS) [MIM:237500]: Autosomal recessive disorder characterized by conjugated hyperbilirubinemia, an increase in the urinary excretion of coproporphyrin isomer I, deposition of melanin-like pigment in hepatocytes, and prolonged retention of sulfobromophthalein, but otherwise normal liver function. {ECO:0000269 PubMed:10053008, ECO:0000269 PubMed:10464142, ECO:0000269 PubMed:11266082, ECO:0000269 PubMed:11477083, ECO:0000269 PubMed:25336012, ECO:0000269 PubMed:9425227}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(3) University of Copenhagen DISEASES for ABCC2 Gene

(57) Novoseek inferred disease relationships for ABCC2 Gene

Disease -log(P) Hits PubMed IDs
dubin-johnson syndrome 95.3 55
hyperbilirubinemia 74.5 26
cholestasis 71.3 23
cholestasis intrahepatic 63.8 3
rotor syndrome 59.4 1

Relevant External Links for ABCC2

Genetic Association Database (GAD)
ABCC2
Human Genome Epidemiology (HuGE) Navigator
ABCC2
genes like me logo Genes that share disorders with ABCC2: view

Publications for ABCC2 Gene

  1. A human canalicular multispecific organic anion transporter (cMOAT) gene is overexpressed in cisplatin-resistant human cancer cell lines with decreased drug accumulation. (PMID: 8797578) Taniguchi K. … Kuwano M. (Cancer Res. 1996) 2 3 4 23
  2. Mutation of Trp1254 in the multispecific organic anion transporter, multidrug resistance protein 2 (MRP2) (ABCC2), alters substrate specificity and results in loss of methotrexate transport activity. (PMID: 11500505) Ito K. … Cole S.P.C. (J. Biol. Chem. 2001) 3 4 23 25
  3. Association between ABCC2 gene haplotypes and tenofovir-induced proximal tubulopathy. (PMID: 17083032) Izzedine H. … Deray A.G. (J. Infect. Dis. 2006) 3 23 25 49
  4. High-dose methotrexate in pediatric acute lymphoblastic leukemia: impact of ABCC2 polymorphisms on plasma concentrations. (PMID: 17112803) Rau T. … Langer T. (Clin. Pharmacol. Ther. 2006) 3 23 25 49
  5. Non-response to antiepileptic pharmacotherapy is associated with the ABCC2 -24C>T polymorphism in young and adult patients with epilepsy. (PMID: 19415824) Ufer M. … Cascorbi I. (Pharmacogenet. Genomics 2009) 3 23 25 49

Products for ABCC2 Gene

  • Pathway & Disease-focused RT² Profiler PCR Arrays
  • QIAGEN qRT-PCR Assays for microRNAs that regulate ABCC2
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for ABCC2
    • Block miRNA regulation of ABCC2 using miScript Target Protectors

    Sources for ABCC2 Gene

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