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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ABCC2 Gene

protein-coding GIFtS: 65
GCID: GC10P101532

ATP-binding cassette, sub-family C (CFTR/MRP), member 2

(Previous name: canalicular multispecific organic anion transporter 1 )
(Previous symbol: CMOAT)

Explore 82 diseases affiliated with
ABCC2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 2¹ ²		Canalicular Multidrug Resistance Protein² ³
CMOAT¹ ² ³ ⁵		Multidrug Resistance-Associated Protein 2² ³
MRP2¹ ² ³		ATP-Binding Cassette Sub-Family C Member 2² ³
DJS¹ ²		ABC30²
CMRP³		CMOAT1³
Canalicular Multispecific Organic Anion Transporter 1¹ ²		CMRP³

External Ids:	HGNC: 53¹	Entrez Gene: 1244²	Ensembl: ENSG00000023839⁷	OMIM: 601107⁵	UniProtKB: Q92887³

Export aliases for ABCC2 gene to outside databases

Previous GC identifers: GC10P100435 GC10P100776 GC10P101673 GC10P101207 GC10P095169

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ABCC2:

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC

proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven

distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily

which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the

hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine; therefore,

this protein appears to contribute to drug resistance in mammalian cells. Several different mutations in this gene

have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by

conjugated hyperbilirubinemia. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: MRP2_HUMAN, Q92887

Function: Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporter

Gene Wiki entry for ABCC2 (Multidrug resistance-associated protein 2)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000010.10 NC_018921.1 NT_030059.13

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ABCC2 gene promoter:
HFH-3 Sox5 GATA-3 FOXD3 GATA-2 FOXL1 FOXI1 FOXC1 FOXJ2 (long isoform) FOXJ2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ABCC2 promoter sequence

Search SABiosciences Chromatin IP Primers for ABCC2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ABCC2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q24 Ensembl cytogenetic band: 10q24.2 HGNC cytogenetic band: 10q24

ABCC2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ABCC2 gene location

GeneLoc information about chromosome 10 GeneLoc Exon Structure

GeneLoc location for GC10P101532: view genomic region (about GC identifiers)

Start:	101,542,463 bp from pter	End:	101,611,949 bp from pter
Size:	69,487 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MRP2_HUMAN, Q92887 (See protein sequence)

Recommended Name: Canalicular multispecific organic anion transporter 1

Size: 1545 amino acids; 174207 Da

Subcellular location: Membrane; Multi-pass membrane protein

Secondary accessions: B2RMT8 Q14022 Q5T2B1 Q92500 Q92798 Q99663 Q9UMS2

Explore the universe of human proteins at neXtProt for ABCC2: NX_Q92887

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q92887

ABCC2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_000383.1

ENSEMBL proteins:

ENSP00000359478 ENSP00000359463

Reactome Protein details: Q92887
Human Recombinant Protein Products for ABCC2:

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	Uscn Proteins for ABCC2

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005624	membrane fraction	--	--
GO:0005886	plasma membrane	TAS	--
GO:0005887	integral to plasma membrane	IEA	--
GO:0016324	apical plasma membrane	ISS	--
GO:0046581	intercellular canaliculus	IEA	--

ABCC2 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for ABCC2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ABCC2 for domains About GeneDecksing

5/7 InterPro domains/families (see all 7):

IPR003439 ABC_transporter-like

IPR001140 ABC_transptr_TM_dom

IPR003593 AAA+_ATPase

IPR017940 ABC_transporter_type1

IPR011527 ABC_transptrTM_dom_typ1

Graphical View of Domain Structure for InterPro Entry Q92887

ProtoNet protein and cluster: Q92887

UniProtKB/Swiss-Prot: MRP2_HUMAN, Q92887

Similarity: Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily

Similarity: Contains 2 ABC transmembrane type-1 domains

Similarity: Contains 2 ABC transporter domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: MRP2_HUMAN, Q92887

Function: Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporter

Genatlas biochemistry entry for ABCC2:

ATP binding cassette superfamily,subfamily C (CFTR/MRP),member 2,mainly expressed in canilicular membranes of

hepatocytes,also present in other apical domains of prolonged cells,such as the epithelial cells of proximal tubule of

kidney

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	--
GO:0005524	ATP binding	IEA	--
GO:0008514	organic anion transmembrane transporter activity	TAS	7559771
GO:0042626	ATPase activity, coupled to transmembrane movement of substances	IEA	--

ABCC2 for ontologies About GeneDecksing

Phenotypes:
4 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Abcc2):

hematopoietic system

homeostasis/metabolism

liver/biliary system

renal/urinary system

ABCC2 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Abcc2^tm1Ahs for ABCC2

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for ABCC2

miRNA Products:		OriGene 3'-UTR Clone: ABCC2 Browse MicroRNA Expression Plasmids
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Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for ABCC2
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Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ABCC2

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/18 super-pathways (see all 18) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Irinotecan Pathway, Pharmacokinetics

Irinotecan Pathway, Pharmacokinetics	1.00	Mycophenolic acid Pathway, Pharmacokinetics	0.50
Irinotecan Pathway	0.73	Taxane Pathway, Pharmacokinetics	0.30
Irinotecan Pathway, Pharmacodynamics	0.50

Codeine and morphine metabolism

	Codeine and morphine metabolism	1.00			Tramadol Pharmacokinetics	0.36
	Codeine and Morphine Pathway, Pharmacokinetics	0.89

Doxorubicin Pathway, Pharmacokinetics

Doxorubicin Pathway, Pharmacokinetics

1.00

Doxorubicin Pathway (Cancer Cell), Pharmacodynamics

0.43

Atorvastatin/Lovastatin/Simvastatin Pathway, Pharmacokinetics

Atorvastatin/Lovastatin/Simvastatin Pathway, Pharmacokinetics

1.00

Statin Pathway - Generalized, Pharmacokinetics

0.70

ABC-family proteins mediated transport

ABC-family proteins mediated transport

1.00

ABC transporters

0.70

Pathway sources
See GeneCards unified pathways
Show all pathways

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for ABCC2

Hepatic ABC Transporters

1 Cell Signaling Technology (CST) Pathway for ABCC2

Glucose / Energy Metabolism

4 BioSystems Pathways for ABCC2

	Codeine and morphine metabolism
	Irinotecan Pathway
	Drug Induction of Bile Acid Pathway
	Nuclear receptors in lipid metabolism and toxicity

2 Reactome Pathways for ABCC2

	ABC-family proteins mediated transport
	Transmembrane transport of small molecules

5/19 PharmGKB Pathways for ABCC2 (see all 19)

	Antigout Preparations Pathway, Pharmacodynamics
	Atorvastatin/Lovastatin/Simvastatin Pathway, Pharmacokinetics
	Carbamazepine Pathway, Pharmacokinetics
	Codeine and Morphine Pathway, Pharmacokinetics
	Doxorubicin Pathway (Cancer Cell), Pharmacodynamics

2 Kegg Pathways (Kegg details for ABCC2):

	ABC transporters
	Bile secretion

ABCC2 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for ABCC2

STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

5/13 Interacting proteins for ABCC2 (Q92887^{1, 3} ENSP00000359478⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 13)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
RDX	P35241³, ENSP00000342830⁴	I2D: score=2 STRING: ENSP00000342830
SLC9A3R1	O14745³, ENSP00000262613⁴	I2D: score=2 STRING: ENSP00000262613
PDZK1	Q5T2W1³, ENSP00000342143⁴	I2D: score=2 STRING: ENSP00000342143
CANX	P27824³, ENSP00000247461⁴	I2D: score=1 STRING: ENSP00000247461
PDZD3	Q86UT5³, ENSP00000327107⁴	I2D: score=1 STRING: ENSP00000327107

About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006810	transport	TAS	7559771
GO:0015711	organic anion transport	TAS	7559771
GO:0055085	transmembrane transport	TAS	--

ABCC2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

ABCC2 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Enzo Life Sciences drugs & compounds for ABCC2

Browse Tocris compounds for ABCC2

2 HMDB Compounds for ABCC2 About this table

Compound	Synonyms	CAS #	PubMed Ids
Bilirubin	(4Z,15Z)-Bilirubin IXa (see all 17)	635-65-4	17517076
Pravastatin	3beta-Hydroxycompactin (see all 7)	81093-37-0	--

10/60 DrugBank Compounds for ABCC2 (see all 60) About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Sulfinpyrazone	Diphenylpyrazone (see all 6)	57-96-5	target	inhibitor	11834888 17229912 10727523 11108662 10917554 11500505
Sulfinpyrazone	Diphenylpyrazone (see all 6)	57-96-5	transporter	substrate inhibitor	11834888 17229912 10727523 11108662 10917554 11500505 11834888 10917554
Probenecid	Probenecid Acid (see all 2)	57-66-9	transporter	substrate inhibitor	15618649 12608533 14511674 10727523 11880368 12538836 19319690
Cyclosporine	Ciclosporin (see all 3)	59865-13-3	transporter	inhibitor	10570049 15618649 12134946 14511674 10421658
Glutathione	5-L-Glutamyl-L-cysteinylglycine (see all 5)	70-18-8	transporter	substrate inhibitor	10024515 10692506 10648470 10491184 1430236
Methotrexate	Amethopterin (see all 12)	59-05-2	transporter	substrate inhibitor	9270020 12608533 10727523 11465411 10363967
Phenobarbital	Fenobarbital (see all 7)	50-06-6	transporter	inducer	11861969 11841808 11323161 9571149 11706036
Vinblastine	--	865-21-4	transporter	substrate inhibitor inducer	12134946 15616150 11323161 17045309 2172249
Indomethacin	IMN (see all 9)	53-86-1	transporter	substrate inhibitor	19541926 10870987 16460798 19319690
Pravastatin	Pravastatin Sodium (see all 4)	81093-37-0	transporter	substrate inhibitor	11748225 15616150 9321514 15901800
Saquinavir	Saquinavir Mesylate (see all 2)	127779-20-8	transporter	substrate	15504753 12384350 12702717 12441801

10/146 Novoseek chemical compound relationships for ABCC2 gene (see all 146) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
mk 571	90.7	12	17855498 (1), 18405608 (1), 18718123 (1), 19201990 (1) (see all 10)
oatp	86.7	15	17724432 (3), 20501720 (1), 19620935 (1), 18838068 (1) (see all 6)
gf 120918	85.6	6	19491037 (1), 18515333 (1), 16244858 (1)
estradiol-17beta-glucuronide	83.7	10	18180270 (2), 11748225 (1), 18761402 (1), 20071452 (1) (see all 5)
probenecid	79.5	32	15849751 (5), 15618649 (2), 15904671 (1), 18267365 (1) (see all 14)
androstane	79	10	11706036 (2), 15382119 (1), 20048746 (1), 19661216 (1) (see all 7)
psc-833	78.8	6	16356829 (1), 17543436 (1), 18195111 (1), 18515333 (1)
bilirubin monoglucuronide	78.5	7	11897625 (1), 19566819 (1), 9355767 (1), 19214140 (1) (see all 5)
s-(2,4-dinitrophenyl)glutathione	78.1	2	9794924 (1), 9525973 (1)
sulfinpyrazone	74.4	9	18180270 (2), 10917554 (1), 14569069 (1), 11500505 (1)

5 PharmGKB related drug/compound annotations for ABCC2 gene About this table

Drug/compound	PharmGKB Annotation
antiepileptics	CA
carbamazepine	CA
doxorubicin	CA
talinolol	CA
tenofovir	CA

Search CenterWatch for drugs/clinical trials and news about ABCC2 / MRP2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ABCC2 gene:

NM_000392.3

Unigene Cluster for ABCC2:

ATP-binding cassette, sub-family C (CFTR/MRP), member 2

Hs.368243 [show with all ESTs]

Unigene Representative Sequence: U49248

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000370449(uc001kqf.2) ENST00000370434 ENST00000496621

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		GenScript: all cDNA clones in your preferred vector: ABCC2 (NM_000392)
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ABCC2

Additional cDNA sequence:

BC136419.1 U49248.1 U63970.1 X96395.2

8 DOTS entries:

DT.216029 DT.99999029 DT.121300501 DT.121300494 DT.216028 DT.100731911 DT.121300498 DT.92046395

24/76 AceView cDNA sequences (see all 76):

AV656541 BF589901 BM765259 AA699522 CA429833 BQ220800 AV660932 BX643341

AA706096 AI566147 U63970 CB155960 H47978 BP359602 AV656926 BM741963

AA931070 BX116034 AV660925 AA989403 CD518414 AV652973 BM804774 BX495933

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ABCC2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AACCTACTAC

About this image

ABCC2 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Mature brain microvascular endothelial cells (Derivation of blood-...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See ABCC2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ABCC2

SOURCE GeneReport for Unigene cluster: Hs.368243

UniProtKB/Swiss-Prot: MRP2_HUMAN, Q92887

Tissue specificity: Found on the apical membrane of polarized cells in liver, kidney and intestine. The highest

expression is found in liver

SABiosciences Expression via Pathway-Focused PCR Arrays including ABCC2:

Nephrotoxicity in human mouse rat

Drug Transporters in human mouse rat

Cancer Drug Resistance in human mouse rat

Hepatotoxicity in human mouse rat

Molecular Toxicology PathwayFinder 384HT in human mouse rat

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ABCC2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ABCC2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for ABCC2 gene from 8/27 species (see all 27) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Abcc2^{1 , 5}	ATP-binding cassette, sub-family C (CFTR/MRP), member more^{1, 5}	80.91(n)¹ 77.76(a)¹		19 (36.67 cM)⁵ 12780¹ NM_013806.2¹ NP_038834.2¹ 43782192⁵
chicken (Gallus gallus)	Aves	ABCC2¹	ATP-binding cassette, sub-family C (CFTR/MRP), member more	65.6(n) 63.91(a)		423828 XM_421698.3 XP_421698.3
lizard (Anolis carolinensis)	Reptilia	ABCC2⁶	--	63(a)	1 ↔ 1	3(38273068-38308779)
zebrafish (Danio rerio)	Actinopterygii	zgc66072²	similar to multidrug resistance protein 2	73.77(n)		393561 BC056740.1
fruit fly (Drosophila melanogaster)	Insecta	Sur³	heart development sulfonylurea receptor	46(a) (best of 2)		31B1 --
worm (Caenorhabditis elegans)	Secernentea	mrp-2³	ATP-binding transport family	41(a) (best of 3)		X(599137-607953) --
thale cress (Arabidopsis thaliana)	eudicotyledons	MRP1¹	ABC transporter C family member 1	50.01(n) 42.47(a)		839920 NM_001036039.1 NP_001031116.1
rice (Oryza sativa)	Liliopsida	AK120122.1²	--	73.92(n)		AK120122.1

ENSEMBL Gene Tree for ABCC2 (if available)
TreeFam Gene Tree for ABCC2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ABCC2 gene

ABCC4² ABCC12² ABCC1² ABCC10² CFTR² ABCC8² ABCC5² ABCC6²

ABCC3² ABCC11² ABCC9²

18/21 SIMAP similar genes for ABCC2 using alignment to 2 protein entries: MRP2_HUMAN (see all proteins) (see all similar genes):

TAP1 DKFZp434I2115 DKFZp781G125 NG-TRA ABCB4 MRP3

CFTR ABCC3 MOAT-B ABCC1 ABCC4 ABCC6

MRP ABCC11 ABCC12 ABCC9 ABCC10 ara

ABCC2 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for ABCC2
PGOHUM00000258120

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 10 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs56199535^1,2	C,F	pathogenic	101578577(+)	`AGCAGC/G/TGGATC`	3	R G W	mis¹		5		MN WA EA CSA	841
rs72558200^1,2	C	pathogenic	101595882(+)	`GAGGCA/GTCTGG`	2	H R	mis¹		0	--	--	--	--
rs72558201^1,2	C	pathogenic	101595950(+)	`CAGTTA/TTCCGT`	2	I F	mis¹		0	--	--	--	--
rs72558202^1,2	C	pathogenic	101605538(+)	`CCCCCA/GGGTGA`	2	Q R	mis¹		0	--	--	--	--
rs187230151^1,2		--	101540642(+)	`AAAGGC/TGCACC`	1	--	us2k¹		0	--	--	--	--
rs148837420^1,2		--	101540647(+)	`TGCACA/CCTGCC`	1	--	us2k¹		0	--	--	--	--
rs146969653^1,2		--	101540674(+)	`AGTTCC/TACAGC`	1	--	us2k¹		0	--	--	--	--
rs116540125^1,2		--	101540715(+)	`ATGGAA/GAATGA`	1	--	us2k¹		1		WA	118
rs78267562^1,2		--	101540828(+)	`TTGTTG/TTTTTT`	1	--	us2k¹		0	--	--	--	--
rs137897750^1,2		--	101540933(+)	`AGTTGC/TCATAT`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for ABCC2 (101542463 - 101611949 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ABCC2: --
Human Gene Mutation Database (HGMD): ABCC2

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ABCC2

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ABCC2 for disorders           About GeneDecksing

OMIM gene information: 601107
OMIM disorders: 237500
UniProtKB/Swiss-Prot: MRP2_HUMAN, Q92887

Defects in ABCC2 are the cause of Dubin-Johnson syndrome (DJS) [MIM:237500]. DJS is an autosomal recessive

disorder characterized by conjugated hyperbilirubinemia, an increase in the urinary excretion of coproporphyrin isomer

I, deposition of melanin-like pigment in hepatocytes, and prolonged retention of sulfobromophthalein, but otherwise

normal liver function

20/82 diseases for ABCC2 (see all 82): About MalaCards

dubin-johnson syndrome factor vii deficiency dysembryoplastic neuroepithelial tumor rotor syndrome

central nervous system lymphoma dna topoisomerase i intrahepatic cholestasis sclerosing cholangitis

primary sclerosing cholangitis cholestasis non-hodgkin lymphoma intrahepatic cholestasis of pregnancy

cholangitis spina bifida primary biliary cirrhosis intractable epilepsy

malignant mesothelioma hepatitis c obstructive jaundice biliary atresia

2 diseases from the University of Copenhagen DISEASES database for ABCC2:

Bilirubin metabolic disorder Cholestasis

10/57 Novoseek disease relationships for ABCC2 gene (see all 57) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
dubin-johnson syndrome	95.3	83	11477083 (3), 10464142 (3), 19881259 (2), 15777714 (2) (see all 42)
hyperbilirubinemia	74.5	41	15965653 (4), 19881259 (2), 15870973 (2), 12884082 (2) (see all 20)
cholestasis	71.3	31	18700187 (3), 2035335 (3), 11481619 (2), 15057744 (2) (see all 17)
cholestasis intrahepatic	63.8	3	17997497 (2), 19882051 (1)
rotor syndrome	59.4	1	7483689 (1)
breast cancer	56.9	95	18845662 (2), 20071452 (2), 20441926 (2), 15180326 (1) (see all 56)
ovarian carcinoma	46.6	22	10767994 (5), 10537344 (4), 15262134 (3), 12216079 (2) (see all 9)
colon adenocarcinoma	42.9	2	15896333 (1), 17430634 (1)
cancer	40	46	10427140 (3), 9398612 (3), 8797578 (1), 9270026 (1) (see all 32)
liver diseases	36.5	22	17725603 (4), 18926681 (2), 9185779 (1), 10319416 (1) (see all 8)

Genetic Association Database (GAD): ABCC2
Human Genome Epidemiology (HuGE) Navigator: ABCC2 (89 documents)

Export disorders for ABCC2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ABCC2 gene, integrated from 9 sources (see all 785):
(articles sorted by number of sources associating them with ABCC2)

Utopia: connect your pdf to the dynamic
world of online information

Mutation of Trp1254 in the multispecific organic anion transporter, multidrug resistance protein 2 (MRP2) (ABCC2), alters substrate specificity and results in loss of methotrexate transport activity. (PubMed id 11500505)^{1, 2, 7, 9} Ito K....Cole S.P.C. (2001)
A human canalicular multispecific organic anion transporter (cMOAT) gene is overexpressed in cisplatin-resistant human cancer cell lines with decreased drug accumulation. (PubMed id 8797578)^{1, 2, 3, 9} Taniguchi K.... Kuwano M. (1996)
Identification and functional analysis of two novel mutations in the multidrug resistance protein 2 gene in Israeli patients with Dubin- Johnson syndrome. (PubMed id 11477083)^{1, 2, 9} Mor-Cohen R....Seligsohn U. (2001)
Exon-intron organization of the human multidrug-resistance protein 2 (MRP2) gene mutated in Dubin-Johnson syndrome. (PubMed id 10464142)^{1, 2, 9} Tsujii H.... Keppler D. (1999)
Evidence for two interacting ligand binding sites in human multidrug resistance protein 2 (ATP binding cassette C2). (PubMed id 12702717)^{1, 7, 9} Zelcer N....Borst P. (2003)
Impaired protein maturation of the conjugate export pump multidrug resistance protein 2 as a consequence of a deletion mutation in Dubin- Johnson syndrome. (PubMed id 11093739)^{1, 2, 9} Keitel V.... Keppler D. (2000)
cDNA cloning of the hepatocyte canalicular isoform of the multidrug resistance protein, cMrp, reveals a novel conjugate export pump deficient in hyperbilirubinemic mutant rats. (PubMed id 8662992)^{1, 2, 9} Buechler M....Keppler D. (1996)
Influence of ABCB1, ABCC1, ABCC2, and ABCG2 haplotypes on the cellular exposure of nelfinavir in vivo. (PubMed id 16041239)^{1, 4, 9} Colombo S....Telenti A. (2005)
High-dose methotrexate in pediatric acute lymphoblastic leukemia: impact of ABCC2 polymorphisms on plasma concentrations. (PubMed id 17112803)^{1, 7, 9} Rau T....Langer T. (2006)
High plasma pravastatin concentrations are associated with single nucleotide polymorphisms and haplotypes of organic anion transporting polypeptide-C (OATP-C, SLCO1B1). (PubMed id 15226675)^{1, 4, 9} Niemi M....Kivisto K.T. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 1244	HGNC: 53	AceView: ABCC2	Ensembl:ENSG00000023839	euGenes: HUgn1244
ECgene: ABCC2	Kegg: 1244	H-InvDB: ABCC2

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ABCC2	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for ABCC2	Genetics and Cytogenetics in Oncology and Haematology
GeneReviews	http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/ABCC2
ABCMdb	http://abcmutations.hegelab.org/proteinDetails?uniprot_id=Q92887

Intellectual Property for ABCC2 gene
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Patent Information for ABCC2 gene:
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ATP-binding cassette, sub-family C (CFTR/MRP), member 2

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ABCC2 Gene

ATP-binding cassette, sub-family C (CFTR/MRP), member 2

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