ABCC2 Gene
protein-coding GIFtS : 68 GCID: GC10 P101532
ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 2 canalicular multispecific organic anion transporter 1 )CMOAT )
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Aliasesfor ABCC2 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
10 fRNAdb ,
12 H-InvDB ,
13 NCBI ,
14 NONCODE ,
and/or 15 RNAdb )About This Section Aliases ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 2 1 2 ATP-Binding Cassette Sub-Family C Member 22 3 CMOAT1 2 3 5 ABC302 Canalicular Multispecific Organic Anion Transporter 11 2 DJS2 Canalicular Multidrug Resistance Protein2 3 cMRP2 Multidrug Resistance-Associated Protein 22 3 CMOAT13 MRP22 3 CMRP3
Export aliases for ABCC2 gene to outside databases Previous GC identifers: GC10P100435 GC10P100776 GC10P101673 GC10P101207 GC10P095169
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Summariesfor ABCC2 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for ABCC2 Gene: The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine; therefore, this protein appears to contribute to drug resistance in mammalian cells. Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia. (provided by RefSeq, Jul 2008) GeneCards Summary for ABCC2 Gene: ABCC2 (ATP-binding cassette, sub-family C (CFTR/MRP), member 2) is a protein-coding gene. Diseases associated with ABCC2 include dubin-johnson syndrome rotor syndrome related super-pathways are Irinotecan Pathway, Pharmacokinetics and Codeine and Morphine Pathway, Pharmacokinetics . GO annotations related to this gene include ATPase activity, coupled to transmembrane movement of substances and organic anion transmembrane transporter activity . An important paralog of this gene is ABCC4 . UniProtKB/Swiss-Prot: MRP2_HUMAN, Q92887 Function : Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporterGene Wiki entry for ABCC2 (Multidrug resistance-associated protein 2) Gene
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Genomic Viewsfor ABCC2 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,miRBase ,UCSC (hg19) and
Ensembl (release 73) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000010.10 NT_030059.13 NC_018921.2 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the ABCC2 gene promoter:HFH-3 Sox5 GATA-3 FOXD3 GATA-2 FOXL1 FOXI1 FOXC1 FOXJ2 (long isoform) FOXJ2 Other transcription factors Search SABiosciences Chromatin IP Primers for ABCC2 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ABCC2
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 10q24 Ensembl cytogenetic band: 10q24.2 HGNC cytogenetic band: 10q24 ABCC2 Gene in genomic location: bands according to Ensembl, locations according to
Entrez Gene Ensembl GeneLoc information about chromosome 10 GeneLoc Exon Structure
GeneLoc location for GC10P101532: view genomic region
(about GC identifiers )
Start: 101,542,463 bp from pter End:
101,611,949 bp from pter
Size: 69,487 bases Orientation:
plus strand
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Proteinsfor ABCC2 gene
(According to
UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE 1 MOPED ,
2 PaxDb , and 3 MAXQB
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Cloud-Clone Corp. ,
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Cloud-Clone Corp. ,
Ontologies according to Gene
Ontology Consortium 01 Oct 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
LSBio ,
Abcam , and/or
Cloud-Clone Corp. )
About This Section UniProtKB/Swiss-Prot: MRP2_HUMAN, Q92887 See
protein sequence )Recommended Name: Size : 1545 amino acids; 174207 DaSubcellular location : Membrane; Multi-pass membrane proteinSecondary accessions : B2RMT8 Q14022 Q5T2B1 Q92500 Q92798 Q99663 Q9UMS2Explore the universe of human proteins at neXtProt for ABCC2: NX_Q92887 Explore proteomics data for ABCC2 at MOPED Post-translational modifications:
View modification sites using PhosphoSitePlus View neXtProt modification sites for NX_Q92887 ABCC2 Protein expression data from MOPED1 2 3 : About this image REFSEQ proteins: NP_000383.1 ENSEMBL proteins: ENSP00000359478 ENSP00000359463 Reactome Protein details: Q92887 Human Recombinant Protein Products for ABCC2: Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6 ): About this table
About GeneDecksing ABCC2 Antibody Products: Assay Products for ABCC2:
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Protein
Domains /for ABCC2 gene (According to HGNC , IUPHAR , InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section HGNC Gene Families: ABCC: ATP binding cassette transporters / subfamily C IUPHAR Guide to PHARMACOLOGY protein family classification: ABCC2 ABCC subfamily 5/8 InterPro protein domains (see all 8 ):
Graphical View of Domain Structure for InterPro Entry Q92887 ProtoNet protein and cluster: Q92887
UniProtKB/Swiss-Prot: MRP2_HUMAN, Q92887 Similarity : Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamilySimilarity : Contains 2 ABC transmembrane type-1 domainsSimilarity : Contains 2 ABC transporter domainsAbout GeneDecksing
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Functionfor ABCC2 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory ,
SABiosciences ,
miRNA Gene Targets from miRTarBase ,
shRNA from
OriGene ,
Sirion Biotech ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Sirion Biotech ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
Sirion Biotech ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Oct 2013 via
Entrez Gene .)
About This Section Molecular Function: UniProtKB/Swiss-Prot Summary: MRP2_HUMAN, Q92887 Function : Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporter
Genatlas biochemistry entry for ABCC2 ATP binding cassette superfamily,subfamily C (CFTR/MRP),member 2,mainly expressed in canilicular membranes of hepatocytes,also present in other apical domains of prolonged cells,such as the epithelial cells of proximal tubule of kidney Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9 ): About this table
About GeneDecksing Phenotypes: 4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Abcc2) :About GeneDecksing Animal Models: Abcc2 tm1Ahs for ABCC2In Situ AssayAdvanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ABCC2
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Pathways & Interactionsfor ABCC2 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Sino Biological ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Oct 2013 via
Entrez Gene) .
About This Section SuperPaths for ABCC2 About (see all 17 ) See pathways by source SuperPath Contained pathways About 1 Irinotecan Pathway, Pharmacokinetics 2 Codeine and morphine metabolism 3 ABC-family proteins mediated transport 4 Atorvastatin/Lovastatin/Simvastatin Pathway, Pharmacokinetics 5 Pravastatin Pathway, Pharmacokinetics
Pathways by source See SuperPaths Show all pathways 1 1 4 2 5/18 ABCC2 (see all 18 )2 (Kegg details for ABCC2) :About GeneDecksing Interactions: SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ABCC2 STRING Interaction
Network Preview (showing 5 interactants - click image to see 11)5/13 Interacting proteins for ABCC2 (Q92887 1 , 3 ENSP00000359478 4 via UniProtKB, MINT, STRING , and/or I2D (see all 13 )About this table Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11 ): About this table
About GeneDecksing
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Drugs & Compoundsfor ABCC2 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
IUPHAR ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section About GeneDecksing Enzo Life Sciences drugs & compounds for ABCC2
Browse Tocris compounds for ABCC2 (MRP2) 2 HMDB Compounds for ABCC2 About this table 10/76 DrugBank Compounds for ABCC2 (see all 76 )About this table 10/146 Novoseek inferred chemical compound relationships for ABCC2 gene (see all 146 ) About this table
Compound
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
mk 571
90.7
12
17855498 (1), 18405608 (1), 18718123 (1), 19201990 (1) (see
all 10 )
oatp
86.7
15
17724432 (3), 20501720 (1), 19620935 (1), 18838068 (1) (see
all 6 )
gf 120918
85.6
6
19491037 (1), 18515333 (1), 16244858 (1)
estradiol-17beta-glucuronide
83.7
10
18180270 (2), 11748225 (1), 18761402 (1), 20071452 (1) (see
all 5 )
probenecid
79.5
32
15849751 (5), 15618649 (2), 15904671 (1), 18267365 (1) (see
all 14 )
androstane
79
10
11706036 (2), 15382119 (1), 20048746 (1), 19661216 (1) (see
all 7 )
psc-833
78.8
6
16356829 (1), 17543436 (1), 18195111 (1), 18515333 (1)
bilirubin monoglucuronide
78.5
7
11897625 (1), 19566819 (1), 9355767 (1), 19214140 (1) (see
all 5 )
s-(2,4-dinitrophenyl)glutathione
78.1
2
9794924 (1), 9525973 (1)
sulfinpyrazone
74.4
9
18180270 (2), 10917554 (1), 14569069 (1), 11500505 (1)
6 PharmGKB related drug/compound annotations for ABCC2 gene About this table ABCC2 / MRP2
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Transcriptsfor ABCC2 gene (Secondary structures according to
fRNAdb ,Unigene
(Build 236 Homo sapiens; Apr 25 2013) or GenBank , Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC , KenesGroup ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,EMD Millipore ,
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
Sirion Biotech ,
microRNA from QIAGEN ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for ABCC2 gene: NM_000392.3 Unigene Cluster for ABCC2:
ATP-binding cassette, sub-family C (CFTR/MRP), member 2 Hs.368243 [show with all ESTs ] Unigene Representative Sequence: U49248 3 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000370449 (uc001kqf.2 ) ENST00000370434 ENST00000496621 Primer human mouse SABiosciences RT2 qPCR Primer Assay in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat
Additional mRNA sequence: BC136419.1 U49248.1 U63970.1 X96395.2
8 DOTS entries : DT.216029 DT.99999029
DT.121300501 DT.121300494 DT.216028 DT.100731911 DT.121300498 DT.92046395 24/76 AceView cDNA sequences (see all 76 ):
AA699522 AV656541 AV660932 BX643341 BQ220800 BM765259 BF589901 CA429833 BX495933 AI566147 R02136 U49248 AV660925 CB155960 AV652973 AA706096 AA931070 BM804774 NM_000392 BP359602 AA187829 BX116034 AI522182 AI823554 GeneLoc Exon Structure
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Expression for ABCC2 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section ABCC2 expression in normal human tissues
(normalized intensities) ABCC2 embryonic expression: see See probesets specificity/sensitivity at GeneAnnot About this image BioGPS 2/3 CGAP TAG: AACCTACTACAbout this image
ABCC2 expression in embryonic tissues and stem cells About this table LifeMap ,
the Embryonic Development and Stem Cells Database 5/5 selected tissues (see all 5 ) fully expand See ABCC2 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for ABCC2 SOURCE GeneReport for Unigene cluster: Hs.368243 UniProtKB/Swiss-Prot: MRP2_HUMAN, Q92887 Tissue specificity : Found on the apical membrane of polarized cells in liver, kidney and intestine. The highestexpression is found in liver SABiosciences Expression via Pathway-Focused PCR Arrays including ABCC2 : Primer human mouse SABiosciences RT2 qPCR Primer Assay in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat In Situ Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ABCC2
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Orthologsfor ABCC2 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section Orthologs for ABCC2 gene from 8/18 species (see all 18 ) About this table
Organism
Taxonomic
Gene
Description
Human
Orthology
Details
mouse Mammalia Abcc21 5
ATP-binding cassette, sub-family C (CFTR/MRP), member more 1, 5
80.91(n) 1 77.76(a) 1
19 (36.67 cM) 5 12780 1 NM_013806.2 1 NP_038834.2 1 43782192 5
chicken Aves ABCC21
ATP-binding cassette, sub-family C (CFTR/MRP), member more
65.6(n) 63.91(a)
423828 XM_421698.3 XP_421698.3
lizard Reptilia ABCC26
Uncharacterized protein
64(a)
1 ↔ 1
3(38272079-38308779)
zebrafish Actinopterygii zgc660722
similar to multidrug resistance protein 2
73.77(n)
393561 BC056740.1
fruit fly Insecta Sur3
heart development sulfonylurea receptor
46(a)
31B1 --
worm Secernentea mrp-23
ATP-binding transport family
41(a)
X(599137-607953) --
thale cress eudicotyledons MRP11
ABC transporter C family member 1
50.01(n) 42.47(a)
839920 NM_001036039.1 NP_001031116.1
rice Liliopsida AK120122.12
--
73.92(n)
AK120122.1
ENSEMBL Gene Tree for ABCC2 (if available)TreeFam Gene Tree for ABCC2 (if available)
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Paralogsfor ABCC2 gene (Paralogs according to
1 HomoloGene ,2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for ABCC2 gene ABCC4 2 ABCC12 2 ABCC10 2 ABCC1 2 CFTR 2 ABCC8 2 ABCC5 2 ABCC3 2 ABCC11 2 ABCC9 2 18/20 SIMAP similar genes for ABCC2 using alignment to 2 protein entries: MRP2_HUMAN (see all proteins )
(see all similar genes ):TAP1 DKFZp434I2115 DKFZp781G125 NG-TRA ABCB4 MRP3 CFTR ABCC3 MOAT-B ABCC1 ABCC4 ABCC6 MRP ABCC11 ABCC12 ABCC9 ABCC10 ara About GeneDecksing 1 Pseudogenes.org Pseudogene for ABCC2 PGOHUM00000258120
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Genomic Variantsfor ABCC2 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
4 UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical Chr 10 pos Sequence # AA Type More # Allele Pop Total More
HapMap Linkage Disequilibrium report for ABCC2 (101542463 - 101611949 bp)
Structural Variations Database of Genomic Variants (DGV) 7 variations for ABCC2 : About this table Human Gene Mutation Database (HGMD) : ABCC2 SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human mouse rat
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Disorders
/ Diseasesfor ABCC2 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database , Conferences by KenesGroup ,
Novoseek , Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section About GeneDecksing OMIM gene information: 601107 OMIM disorders : 237500 UniProtKB/Swiss-Prot: MRP2_HUMAN, Q92887 Dubin-Johnson syndrome (DJS) [MIM:237500]: Autosomal recessive disorder characterized by conjugated hyperbilirubinemia, an increase in the urinary excretion of coproporphyrin isomer I, deposition of melanin-like pigment in hepatocytes, and prolonged retention of sulfobromophthalein, but otherwise normal liver function. Note=The disease is caused by mutations affecting the gene represented in this entry 20/76 (see all 76 ): About MalaCards dubin-johnson syndrome rotor syndrome cholestasis intrahepatic cholestasis of pregnancy dysembryoplastic neuroepithelial tumor intrahepatic cholestasis cholangitis factor vii deficiency hepatocellular adenoma central nervous system lymphoma hepatoblastoma obstructive jaundice sclerosing cholangitis malignant mesothelioma primary sclerosing cholangitis biliary atresia leukopenia primary biliary cirrhosis jaundice nasopharyngitis 3 diseases from the University of Copenhagen DISEASES database for ABCC2 :Bilirubin metabolic disorder Cholestasis Cancer Congresses - knowledge worth sharing: Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015 10/57 Novoseek inferred disease relationships for ABCC2 gene (see all 57 ) About this table
Disease
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
dubin-johnson syndrome
95.3
83
11477083 (3), 10464142 (3), 19881259 (2), 15777714 (2) (see
all 42 )
hyperbilirubinemia
74.5
41
15965653 (4), 19881259 (2), 15870973 (2), 12884082 (2) (see
all 20 )
cholestasis
71.3
31
18700187 (3), 2035335 (3), 11481619 (2), 15057744 (2) (see
all 17 )
cholestasis intrahepatic
63.8
3
17997497 (2), 19882051 (1)
rotor syndrome
59.4
1
7483689 (1)
breast cancer
56.9
95
18845662 (2), 20071452 (2), 20441926 (2), 15180326 (1) (see
all 56 )
ovarian carcinoma
46.6
22
10767994 (5), 10537344 (4), 15262134 (3), 12216079 (2) (see
all 9 )
colon adenocarcinoma
42.9
2
15896333 (1), 17430634 (1)
cancer
40
46
10427140 (3), 9398612 (3), 8797578 (1), 9270026 (1) (see
all 32 )
liver diseases
36.5
22
17725603 (4), 18926681 (2), 9185779 (1), 10319416 (1) (see
all 8 )
Genetic Association Database (GAD): ABCC2 Human Genome Epidemiology (HuGE) Navigator: ABCC2 (89 documents) Export disorders for ABCC2 gene to outside databases
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Publicationsfor ABCC2 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for ABCC2 gene, integrated from 9 sources (see all 812 ):(articles sorted by number of sources associating them with ABCC2) Utopia : connect your pdf to the dynamic
Mutation of Trp1254 in the multispecific organic anion transporter, multidrug resistance protein 2 (MRP2) (ABCC2), alters substrate specificity and results in loss of methotrexate transport activity. (PubMed id 11500505) 1 , 2 , 7, 9(2001) Non-response to antiepileptic pharmacotherapy is associated with the ABCC2 -24C>T polymorphism in young and adult patients with epilepsy. (PubMed id 19415824) 1 , 4, 7, 9(2009) High-dose methotrexate in pediatric acute lymphoblastic leukemia: impact of ABCC2 polymorphisms on plasma concentrations. (PubMed id 17112803) 1 , 4, 7, 9(2006) Association between ABCC2 gene haplotypes and tenofovir-induced proximal tubulopathy. (PubMed id 17083032) 1 , 4, 7, 9(2006) A human canalicular multispecific organic anion transporter (cMOAT) gene is overexpressed in cisplatin-resistant human cancer cell lines with decreased drug accumulation. (PubMed id 8797578) 1 , 2 , 3, 9(1996) Integrated pharmacogenetic prediction of irinotecan pharmacokinetics and toxicity in patients with advanced non-small cell lung cancer. (PubMed id 18221820) 1 , 4, 7(2008) Identification and functional analysis of two novel mutations in the multidrug resistance protein 2 gene in Israeli patients with Dubin- Johnson syndrome. (PubMed id 11477083) 1 , 2 , 9(2001) Multidrug resistance-related protein 2 genotype of the donor affects kidney graft function. (PubMed id 19214140) 1 , 4, 9(2009) Exon-intron organization of the human multidrug-resistance protein 2 (MRP2) gene mutated in Dubin-Johnson syndrome. (PubMed id 10464142) 1 , 2 , 9(1999) MRP2 haplotypes confer differential susceptibility to toxic liver injury. (PubMed id 17502832) 1 , 4, 9(2007)
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External Searches for ABCC2 gene
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Genome Databases showing ABCC2 gene
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miRBase ,
ECgene ,
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and/or
H-InvDB )
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Other Databases showing ABCC2 gene
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Specialized Databases showing ABCC2 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description PharmGKB entry for ABCC2 Pharmacogenomics, SNPs, Pathways ATLAS Chromosomes in Cancer entry for ABCC2Genetics and Cytogenetics in Oncology and Haematology GeneReviews http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/ABCC2 ABCMdb http://abcmutations.hegelab.org/proteinDetails?uniprot_id=Q92887
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About This Section Patent Information for ABCC2 gene: ABCC2 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor ABCC2 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Cloud-Clone Corp. , Thermo Fisher Scientific , LSBio , Gene Editing from DNA2.0 and Sirion Biotech , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript , LifeMap BioReagents , and Sirion Biotech , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences , In Situ Hybridization Assays from Advanced Cell Diagnostics , Animal models from inGenious Targeting Laboratory )About This Section
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ABCC2 QIAGEN SeqTarget long-range PCR primers in human mouse rat QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ABCC2 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat
Antibodies & Assays for ABCC2
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ABCC2
ThermoFisher Antibodies for ABCC2
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat ABCC2
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