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Aliases for ABCC12 Gene

Aliases for ABCC12 Gene

  • ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 12 2 3
  • ATP-Binding Cassette Sub-Family C Member 12 3 4
  • MRP9 3 4
  • ATP-Binding Cassette Transporter Sub-Family C Member 12 3

External Ids for ABCC12 Gene

Previous GeneCards Identifiers for ABCC12 Gene

  • GC16M038531
  • GC16M048165
  • GC16M047854
  • GC16M047894
  • GC16M046674
  • GC16M034007

Summaries for ABCC12 Gene

Entrez Gene Summary for ABCC12 Gene

  • This gene is a member of the superfamily of ATP-binding cassette (ABC) transporters and the encoded protein contains two ATP-binding domains and 12 transmembrane regions. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies: ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White. This gene is a member of the MRP subfamily which is involved in multi-drug resistance. This gene and another subfamily member are arranged head-to-tail on chromosome 16q12.1. Increased expression of this gene is associated with breast cancer. [provided by RefSeq, Jul 2008]

GeneCards Summary for ABCC12 Gene

ABCC12 (ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 12) is a Protein Coding gene. Among its related pathways are ABC-family proteins mediated transport. GO annotations related to this gene include ATPase activity and ATPase activity, coupled to transmembrane movement of substances. An important paralog of this gene is ABCC5.

UniProtKB/Swiss-Prot for ABCC12 Gene

  • Probable transporter.

Gene Wiki entry for ABCC12 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ABCC12 Gene

Genomics for ABCC12 Gene

Regulatory Elements for ABCC12 Gene

Genomic Location for ABCC12 Gene

Chromosome:
16
Start:
48,082,973 bp from pter
End:
48,156,018 bp from pter
Size:
73,046 bases
Orientation:
Minus strand

Genomic View for ABCC12 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ABCC12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ABCC12 Gene

Proteins for ABCC12 Gene

  • Protein details for ABCC12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96J65-MRP9_HUMAN
    Recommended name:
    Multidrug resistance-associated protein 9
    Protein Accession:
    Q96J65
    Secondary Accessions:
    • Q49AL2
    • Q8TAF0
    • Q8TEY2

    Protein attributes for ABCC12 Gene

    Size:
    1359 amino acids
    Molecular mass:
    152297 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ABCC12 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ABCC12 Gene

Proteomics data for ABCC12 Gene at MOPED

Post-translational modifications for ABCC12 Gene

  • Glycosylation at Asn 405, Asn 438, Asn 540, and Asn 981
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for ABCC12 Gene

Domains & Families for ABCC12 Gene

Gene Families for ABCC12 Gene

Protein Domains for ABCC12 Gene

Graphical View of Domain Structure for InterPro Entry

Q96J65

UniProtKB/Swiss-Prot:

MRP9_HUMAN :
  • Contains 2 ABC transmembrane type-1 domains.
  • Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
Domain:
  • Contains 2 ABC transmembrane type-1 domains.
  • Contains 2 ABC transporter domains.
Family:
  • Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
genes like me logo Genes that share domains with ABCC12: view

Function for ABCC12 Gene

Molecular function for ABCC12 Gene

UniProtKB/Swiss-Prot Function:
Probable transporter.

Gene Ontology (GO) - Molecular Function for ABCC12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
GO:0016887 ATPase activity --
GO:0042626 ATPase activity, coupled to transmembrane movement of substances IEA --
genes like me logo Genes that share ontologies with ABCC12: view

Phenotypes for ABCC12 Gene

genes like me logo Genes that share phenotypes with ABCC12: view

Animal Model Products

miRNA for ABCC12 Gene

miRTarBase miRNAs that target ABCC12

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ABCC12

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for ABCC12 Gene

Localization for ABCC12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ABCC12 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ABCC12 Gene COMPARTMENTS Subcellular localization image for ABCC12 gene
Compartment Confidence
mitochondrion 2

Gene Ontology (GO) - Cellular Components for ABCC12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ABCC12: view

Pathways & Interactions for ABCC12 Gene

SuperPathways for ABCC12 Gene

Superpath Contained pathways
1 ABC-family proteins mediated transport
genes like me logo Genes that share pathways with ABCC12: view

Pathways by source for ABCC12 Gene

1 KEGG pathway for ABCC12 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for ABCC12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport --
GO:0008152 metabolic process IEA --
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with ABCC12: view

No data available for SIGNOR curated interactions for ABCC12 Gene

Drugs & Compounds for ABCC12 Gene

No Compound Related Data Available

Transcripts for ABCC12 Gene

Unigene Clusters for ABCC12 Gene

ATP-binding cassette, sub-family C (CFTR/MRP), member 12:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ABCC12

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ABCC12 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20 ^
SP1: -
SP2: - -
SP3: - -
SP4: - -
SP5: - - -
SP6: - - -
SP7: - - - -
SP8:
SP9:
SP10:
SP11:

ExUns: 21 ^ 22a · 22b ^ 23a · 23b ^ 24 ^ 25a · 25b · 25c ^ 26 ^ 27 ^ 28 ^ 29 ^ 30a · 30b · 30c
SP1: - - - -
SP2: - - -
SP3: - - - - -
SP4: - - - -
SP5: - - - -
SP6: - - - -
SP7: - - - -
SP8:
SP9:
SP10:
SP11:

Relevant External Links for ABCC12 Gene

GeneLoc Exon Structure for
ABCC12
ECgene alternative splicing isoforms for
ABCC12

Expression for ABCC12 Gene

mRNA expression in normal human tissues for ABCC12 Gene

mRNA differential expression in normal tissues according to GTEx for ABCC12 Gene

This gene is overexpressed in Testis (x21.7), Brain - Cortex (x8.3), Brain - Frontal Cortex (BA9) (x6.5), and Brain - Anterior cingulate cortex (BA24) (x4.8).

Protein differential expression in normal tissues from HIPED for ABCC12 Gene

This gene is overexpressed in Heart (46.3) and Plasma (10.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ABCC12 Gene



SOURCE GeneReport for Unigene cluster for ABCC12 Gene Hs.410111

mRNA Expression by UniProt/SwissProt for ABCC12 Gene

Q96J65-MRP9_HUMAN
Tissue specificity: Expressed in testis (at protein level). Widely expressed at low level. Isoform 5 is specifically expressed in brain, testis and breast cancer cells.
genes like me logo Genes that share expression patterns with ABCC12: view

Protein tissue co-expression partners for ABCC12 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for ABCC12 Gene

Orthologs for ABCC12 Gene

This gene was present in the common ancestor of animals.

Orthologs for ABCC12 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ABCC12 35
  • 88.63 (n)
  • 88.34 (a)
ABCC12 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ABCC12 35
  • 88.68 (n)
  • 88.85 (a)
ABCC12 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Abcc12 35
  • 84.5 (n)
  • 85.46 (a)
Abcc12 16
Abcc12 36
  • 85 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ABCC12 35
  • 98.97 (n)
  • 98.6 (a)
ABCC12 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Abcc12 35
  • 83.84 (n)
  • 84.43 (a)
oppossum
(Monodelphis domestica)
Mammalia ABCC12 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ABCC12 36
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ABCC12 36
  • 59 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii abcc12 35
  • 59.48 (n)
  • 54.87 (a)
abcc12 36
  • 51 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Sur 37
  • 43 (a)
Sur 36
  • 18 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.6538 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 39 (a)
OneToMany
Species with no ortholog for ABCC12:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ABCC12 Gene

ENSEMBL:
Gene Tree for ABCC12 (if available)
TreeFam:
Gene Tree for ABCC12 (if available)

Paralogs for ABCC12 Gene

Paralogs for ABCC12 Gene

genes like me logo Genes that share paralogs with ABCC12: view

Variants for ABCC12 Gene

Sequence variations from dbSNP and Humsavar for ABCC12 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs933554 -- 48,123,886(-) ATTTA(A/G)AAATG intron-variant
rs939360 -- 48,130,573(+) AGAGA(C/T)TATCT intron-variant
rs939362 -- 48,131,667(+) TGTCC(A/G)AATTG intron-variant
rs961668 -- 48,130,062(-) GTCAT(C/T)GTAAG intron-variant
rs1345425 -- 48,125,388(-) CATAA(A/G)GACCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ABCC12 Gene

Variant ID Type Subtype PubMed ID
nsv520355 CNV Gain 19592680
esv2658965 CNV Deletion 23128226

Variation tolerance for ABCC12 Gene

Residual Variation Intolerance Score: 96.13% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.76; 89.43% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ABCC12 Gene

HapMap Linkage Disequilibrium report
ABCC12
Human Gene Mutation Database (HGMD)
ABCC12

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ABCC12 Gene

Disorders for ABCC12 Gene

Relevant External Links for ABCC12

Genetic Association Database (GAD)
ABCC12
Human Genome Epidemiology (HuGE) Navigator
ABCC12
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ABCC12
genes like me logo Genes that share disorders with ABCC12: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ABCC12 Gene

Publications for ABCC12 Gene

  1. ATP-binding cassette C transporters in human pancreatic carcinoma cell lines. Upregulation in 5-fluorouracil-resistant cells. (PMID: 19077464) Hagmann W. … LAPhr J.M. (Pancreatology 2009) 23 67
  2. ABCC10, ABCC11, and ABCC12. (PMID: 16868766) Kruh G.D. … Chen Z.S. (Pflugers Arch. 2007) 23 67
  3. Multidrug resistance-associated protein 9 (ABCC12) is present in mouse and boar sperm. (PMID: 17472575) Ono N. … Borst P. (Biochem. J. 2007) 23 67
  4. Characterization of the mouse Abcc12 gene and its transcript encoding an ATP-binding cassette transporter, an orthologue of human ABCC12. (PMID: 12801629) Shimizu H. … Ishikawa T. (Gene 2003) 23 67
  5. MRP9, an unusual truncated member of the ABC transporter superfamily, is highly expressed in breast cancer. (PMID: 12011458) Bera T.K. … Pastan I. (Proc. Natl. Acad. Sci. U.S.A. 2002) 23 67

Products for ABCC12 Gene

Sources for ABCC12 Gene

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