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Aliases & Descriptions for ABCC12
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| MGC27071 2 | | MRP9 1, 2, 3, 5 | | OTTHUMP00000164186 2 |
| | | Descriptions |
|---|
| ATP-binding cassette protein C12 2 | | ATP-binding cassette transporter sub-family C member 12 2, 3 | | ATP-binding cassette, sub-family C (CFTR/MRP), member 12 2 | | multidrug resistance-associated protein 9 2 |
|
| | Search outside databases for aliases for ABCC12 genePrevious GC identifers: GC16M038531 GC16M048165 GC16M047854 GC16M047894 |
Summaries for ABCC12(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for ABCC12: This gene is a member of the superfamily of ATP-binding cassette (ABC) transporters and the encoded protein contains two ATP-binding domains and 12 transmembrane regions. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies: ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White. This gene is a member of the MRP subfamily which is involved in multi-drug resistance. This gene and another subfamily member are arranged head-to-tail on chromosome 16q12.1. Increased expression of this gene is associated with breast cancer. [provided by RefSeq] UniProtKB/Swiss-Prot: MRP9_HUMAN, Q96J65Function: Probable transporter (By similarity)Gene Wiki entry for ABCC12 |
Genomic Location for ABCC12
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the ABCC12 gene 
Entrez Gene cytogenetic band: 16q12.1 Ensembl cytogenetic band: 16q12.1 HGNC cytogenetic band: 16q12.1ABCC12 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16M046674:
(about GC identifiers)
Start:
|
46,674,385 bp from pter |
End:
|
46,738,182 bp from pter |
Size:
|
63,798 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000016.8 NT_010498.15
| Proteins for ABCC12
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: MRP9_HUMAN, Q96J65 (See
protein sequence)Recommended Name: Multidrug resistance-associated protein 9 Size: 1359 amino acids; 152297 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Developmental stage: Expressed in fetal tissues
Secondary accessions: Q49AL2 Q8TAF0 Q8TEY2Alternative splicing: 5 isoforms: Q96J65-1 Q96J65-2 Q96J65-3 Q96J65-4 Q96J65-5 REFSEQ proteins: NP_150229.2
ENSEMBL proteins: ENSP00000311030
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
2 Gene Ontology (GO) cellular component terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016020 | membrane |
IEA | -- | | GO:0016021 | integral to membrane |
IEA | -- | About this table
Antibodies for ABCC12: Assays for ABCC12: | Protein
Domains/ Families for ABCC12(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q96J65
ProtoNet protein and cluster: Q96J65 UniProtKB/Swiss-Prot: MRP9_HUMAN, Q96J65Similarity: Belongs to the ABC transporter family. Conjugate transporter (TC 3.A.1.208) subfamilySimilarity: Contains 2 ABC transmembrane type-1 domainsSimilarity: Contains 2 ABC transporter domains | Gene Function for ABCC12
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|                OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 5): NM_033226
Applied Biosystems Silencer® siRNAs for ABCC12
Sigma-Aldrich siRNA and siRNA Panels for ABCC12  Sigma-Aldrich shRNA for ABCC12  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_033226                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_033226                                  untagged cDNA clone in CMV expression vector: NM_033226 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_033226
UniProtKB/Swiss-Prot: MRP9_HUMAN, Q96J65Function: Probable transporter (By similarity)1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Abcc12):
4 Gene Ontology (GO) molecular function terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000166 | nucleotide binding |
IEA | -- | | GO:0005524 | ATP binding |
IEA | -- | | GO:0016887 | ATPase activity |
IEA | -- | | GO:0042626 | ATPase activity, coupled to transmembrane movement of substances |
IEA | -- | About this table | Pathways & Interactions for ABCC12
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
1 Interacting protein for ABCC12 (ENSP000003110303) via UniProtKB, MINT, and/or STRINGAbout this table
1 Gene Ontology (GO) biological process term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006810 | transport |
IEA | -- | About this table
|
Drugs & Compounds for ABCC12(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for ABCC12
|
Transcripts for ABCC12(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|                OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 5): NM_033226
Sigma-Aldrich siRNA and siRNA Panels for ABCC12  Sigma-Aldrich shRNA for ABCC12  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_033226 REFSEQ mRNAs for ABCC12 gene: NM_033226.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_033226               OriGene GFP tagged cDNA clone in CMV expression vector: NM_033226                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_033226                                  untagged cDNA clone in CMV expression vector: NM_033226  Additional cDNA sequence: AK122635.1 AK302520.1 AK307109.1 AK308599.1 AY040220.1 7 DOTS entries: DT.95099023 DT.101960525 DT.97835594 DT.87014331 DT.100749891 DT.101982304 DT.91992476 20 AceView cDNA sequences:NM_145188 NM_033226 NM_145189 AY196326 AY040220 AK122635 NM_145190 BC036378 AK127951 NM_145187 BX646798 AF395908 AF395909 BG723063 AF411578 AA723717 AF411577 AW341683 CD637552 AA970140
highest scoring ESTs for ABCC12:AY040220 BG723063 AA723717 AA970140 AF395908 AF395909 AF411577 AF411578 AK122635 AY196326 Unigene Cluster for ABCC12: ATP-binding cassette, sub-family C (CFTR/MRP), member 12 Hs.410111 [show with all ESTs]Unigene Representative Sequence: AY040220
GeneLoc Exon Structure
5/11 Alternative Splicing Database (ASD) splice patterns (SP) for ABCC12 (see all 11
)
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b | ^ | 16a | · | 16b | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | |
| SP1: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | - |   |
| ExUns: | 21 | ^ | 22a | · | 22b | ^ | 23a | · | 23b | ^ | 24 | ^ | 25a | · | 25b | · | 25c | ^ | 26 | ^ | 27 | ^ | 28 | ^ | 29 | ^ | 30a | · | 30b | · | 30c | |
| SP1: | |   | - |   | |   | - |   | |   | |   | |   | |   | - |   | |   | - |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | - |   | |   | |   | |   | |   | - |   | |   | - |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | - |   | |   | |   | |   | - |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | - |   | |   | |   | |   | |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | - |   | |   | |   | |   | - |   | - |   | |   | - |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for ABCC12
1 Ensembl transcript including schematic representation: ENST00000311303
|
Expression for ABCC12
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| ABCC12 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for ABCC12
1 / 2 / 3 2 probe-sets matching ABCC12 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: GGAAAATGCC
SOURCE GeneReport for Unigene cluster: Hs.410111 UniProtKB/Swiss-Prot: MRP9_HUMAN, Q96J65Tissue specificity: Expressed in testis (at protein level). Widely expressed at low level. Isoform 5 is specifically expressed in brain, testis and breast cancer cells |
Orthologs for ABCC12
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for ABCC12 gene from 5/7 species (see all 7
)
| Organism |
Gene |
Locus |
Description |
Human Similarity |
NCBI accessions |
dog (Canis familiaris) |
ABCC121 |
-- |
ATP-binding cassette, sub-family C (CFTR/MRP), member more |
88.49(n) 88.63(a) |
487294 XM_544420.2 XP_544420.2 |
chimpanzee (Pan troglodytes) |
ABCC121 |
-- |
ATP-binding cassette, sub-family C (CFTR/MRP), member more |
96.76(n) 95.93(a) |
745745 XM_001163361.1 XP_001163361.1 |
rat (Rattus norvegicus) |
Abcc121 |
-- |
ATP-binding cassette, sub-family C (CFTR/MRP), member more |
83.84(n) 84.43(a) |
291923 NM_199377.1 NP_955409.1 |
mouse (Mus musculus) |
Abcc121, 5 |
8 (42.00 cM)5
|
ATP-binding cassette, sub-family C (CFTR/MRP), member more1, 5 |
84.5(n)1 85.46(a)1 |
2445621 NM_172912.41 NP_766500.31 AF5021465 AF5144145 (see all 14) |
zebrafish (Danio rerio) |
LOC5684821 |
-- |
similar to ATP-binding cassette protein C12 |
59.17(n) 54.39(a) |
568482 XM_691812.3 XP_696904.3 |
About this table Species with no ortholog for ABCC12
ENSEMBL Gene Tree for ABCC12 | Paralogs for ABCC12(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for ABCC12 gene
- ABCC112
|
SNPs/Variants for ABCC12(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for ABCC12 (up to first 250kb)
|
Disorders & Mutations for ABCC12
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 607041
|
Medical News for ABCC12(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for ABCC12 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/13 PubMed articles for ABCC12 gene (see all 13
):- Two new genes from the human ATP-binding cassette transporter superfamily, ABCC11 and ABCC12, tandemly duplicated on chromosome 16q12. (PubMed id 11483364)2, 3, 4 Tammur J....Allikmets R. (2001)
- MRP9, an unusual truncated member of the ABC transporter superfamily, is highly expressed in breast cancer. (PubMed id 12011458)1, 3, 4 Bera T.K.... Pastan I. (2002)
- Multiple splicing variants of two new human ATP-binding cassette transporters, ABCC11 and ABCC12. (PubMed id 11688999)1, 3, 4 Yabuuchi H.... Ishikawa T. (2001)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- The human ATP-binding cassette (ABC) transporter superfamily. (PubMed id 11435397)2, 3 Dean M....Allikmets R. (2001)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)3 Kimura K.... Sugano S. (2006)
- The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)4 Martin J.... Pennacchio L.A. (2004)
- The MRP-related and BCRP/ABCG2 multidrug resistance proteins: biology, substrate specificity and regulation. (PubMed id 14965249)3 Haimeur A....Cole S.P. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)3 Strausberg R.L....Marra M.A. (2002)
- Characterization of the mouse Abcc12 gene and its transcript encoding an ATP-binding cassette transporter, an orthologue of human ABCC12. (PubMed id 12801629)1 Shimizu H....Ishikawa T. (2003)
|
Search for ABCC12
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing ABCC12
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing ABCC12
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ABCC12(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for ABCC12(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for ABCC12:

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Incremental update: 13 Oct 2009
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