Aliases for ABCC12 Gene
External Ids for ABCC12 Gene
Previous GeneCards Identifiers for ABCC12 Gene
This gene is a member of the superfamily of ATP-binding cassette (ABC) transporters and the encoded protein contains two ATP-binding domains and 12 transmembrane regions. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies: ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White. This gene is a member of the MRP subfamily which is involved in multi-drug resistance. This gene and another subfamily member are arranged head-to-tail on chromosome 16q12.1. Increased expression of this gene is associated with breast cancer. [provided by RefSeq, Jul 2008]
GeneCards Summary for ABCC12 Gene
ABCC12 (ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 12) is a Protein Coding gene. Diseases associated with ABCC12 include dubin-johnson syndrome and breast cancer. Among its related pathways are ABC-family proteins mediated transport. GO annotations related to this gene include ATPase activity, coupled to transmembrane movement of substances. An important paralog of this gene is ABCC5.
UniProtKB/Swiss-Prot for ABCC12 Gene