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Aliases for ABCC12 Gene

Aliases for ABCC12 Gene

  • ATP Binding Cassette Subfamily C Member 12 2 3 5
  • ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 12 2 3
  • ATP-Binding Cassette Sub-Family C Member 12 3 4
  • MRP9 3 4
  • ATP-Binding Cassette Transporter Sub-Family C Member 12 3

External Ids for ABCC12 Gene

Previous GeneCards Identifiers for ABCC12 Gene

  • GC16M038531
  • GC16M048165
  • GC16M047854
  • GC16M047894
  • GC16M046674
  • GC16M034007

Summaries for ABCC12 Gene

Entrez Gene Summary for ABCC12 Gene

  • This gene is a member of the superfamily of ATP-binding cassette (ABC) transporters and the encoded protein contains two ATP-binding domains and 12 transmembrane regions. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies: ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White. This gene is a member of the MRP subfamily which is involved in multi-drug resistance. This gene and another subfamily member are arranged head-to-tail on chromosome 16q12.1. Increased expression of this gene is associated with breast cancer. [provided by RefSeq, Jul 2008]

GeneCards Summary for ABCC12 Gene

ABCC12 (ATP Binding Cassette Subfamily C Member 12) is a Protein Coding gene. Among its related pathways are ABC-family proteins mediated transport. GO annotations related to this gene include ATPase activity and ATPase activity, coupled to transmembrane movement of substances. An important paralog of this gene is ABCC5.

UniProtKB/Swiss-Prot for ABCC12 Gene

  • Probable transporter.

Gene Wiki entry for ABCC12 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ABCC12 Gene

Genomics for ABCC12 Gene

Regulatory Elements for ABCC12 Gene

Enhancers for ABCC12 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ABCC12 on UCSC Golden Path with GeneCards custom track

Genomic Location for ABCC12 Gene

48,082,973 bp from pter
48,156,018 bp from pter
73,046 bases
Minus strand

Genomic View for ABCC12 Gene

Genes around ABCC12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ABCC12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ABCC12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ABCC12 Gene

Proteins for ABCC12 Gene

  • Protein details for ABCC12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Multidrug resistance-associated protein 9
    Protein Accession:
    Secondary Accessions:
    • Q49AL2
    • Q8TAF0
    • Q8TEY2

    Protein attributes for ABCC12 Gene

    1359 amino acids
    Molecular mass:
    152297 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ABCC12 Gene


neXtProt entry for ABCC12 Gene

Proteomics data for ABCC12 Gene at MOPED

Post-translational modifications for ABCC12 Gene

  • Glycosylation at Asn 405, Asn 438, Asn 540, and Asn 981
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for ABCC12 Gene

Domains & Families for ABCC12 Gene

Gene Families for ABCC12 Gene

Protein Domains for ABCC12 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 2 ABC transmembrane type-1 domains.
  • Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
  • Contains 2 ABC transmembrane type-1 domains.
  • Contains 2 ABC transporter domains.
  • Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
genes like me logo Genes that share domains with ABCC12: view

Function for ABCC12 Gene

Molecular function for ABCC12 Gene

UniProtKB/Swiss-Prot Function:
Probable transporter.
genes like me logo Genes that share phenotypes with ABCC12: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ABCC12

miRNA for ABCC12 Gene

miRTarBase miRNAs that target ABCC12

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ABCC12 Gene

Localization for ABCC12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ABCC12 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for ABCC12 Gene COMPARTMENTS Subcellular localization image for ABCC12 gene
Compartment Confidence
plasma membrane 3

No data available for Gene Ontology (GO) - Cellular Components for ABCC12 Gene

Pathways & Interactions for ABCC12 Gene

SuperPathways for ABCC12 Gene

Superpath Contained pathways
1 ABC-family proteins mediated transport
genes like me logo Genes that share pathways with ABCC12: view

Pathways by source for ABCC12 Gene

1 KEGG pathway for ABCC12 Gene

Gene Ontology (GO) - Biological Process for ABCC12 Gene


No data available for SIGNOR curated interactions for ABCC12 Gene

Drugs & Compounds for ABCC12 Gene

No Compound Related Data Available

Transcripts for ABCC12 Gene

Unigene Clusters for ABCC12 Gene

ATP-binding cassette, sub-family C (CFTR/MRP), member 12:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ABCC12 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20 ^
SP1: -
SP2: - -
SP3: - -
SP4: - -
SP5: - - -
SP6: - - -
SP7: - - - -

ExUns: 21 ^ 22a · 22b ^ 23a · 23b ^ 24 ^ 25a · 25b · 25c ^ 26 ^ 27 ^ 28 ^ 29 ^ 30a · 30b · 30c
SP1: - - - -
SP2: - - -
SP3: - - - - -
SP4: - - - -
SP5: - - - -
SP6: - - - -
SP7: - - - -

Relevant External Links for ABCC12 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ABCC12 Gene

mRNA expression in normal human tissues for ABCC12 Gene

mRNA differential expression in normal tissues according to GTEx for ABCC12 Gene

This gene is overexpressed in Testis (x21.7), Brain - Cortex (x8.3), Brain - Frontal Cortex (BA9) (x6.5), and Brain - Anterior cingulate cortex (BA24) (x4.8).

Protein differential expression in normal tissues from HIPED for ABCC12 Gene

This gene is overexpressed in Heart (46.3) and Plasma (10.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ABCC12 Gene

SOURCE GeneReport for Unigene cluster for ABCC12 Gene Hs.410111

mRNA Expression by UniProt/SwissProt for ABCC12 Gene

Tissue specificity: Expressed in testis (at protein level). Widely expressed at low level. Isoform 5 is specifically expressed in brain, testis and breast cancer cells.
genes like me logo Genes that share expression patterns with ABCC12: view

Protein tissue co-expression partners for ABCC12 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for ABCC12 Gene

Orthologs for ABCC12 Gene

This gene was present in the common ancestor of animals.

Orthologs for ABCC12 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ABCC12 35
  • 88.63 (n)
  • 88.34 (a)
ABCC12 36
  • 87 (a)
(Canis familiaris)
Mammalia ABCC12 35
  • 88.68 (n)
  • 88.85 (a)
ABCC12 36
  • 88 (a)
(Mus musculus)
Mammalia Abcc12 35
  • 84.5 (n)
  • 85.46 (a)
Abcc12 16
Abcc12 36
  • 85 (a)
(Pan troglodytes)
Mammalia ABCC12 35
  • 98.97 (n)
  • 98.6 (a)
ABCC12 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Abcc12 35
  • 83.84 (n)
  • 84.43 (a)
(Monodelphis domestica)
Mammalia ABCC12 36
  • 76 (a)
(Ornithorhynchus anatinus)
Mammalia ABCC12 36
  • 69 (a)
(Anolis carolinensis)
Reptilia ABCC12 36
  • 59 (a)
(Danio rerio)
Actinopterygii abcc12 35
  • 59.48 (n)
  • 54.87 (a)
abcc12 36
  • 51 (a)
fruit fly
(Drosophila melanogaster)
Insecta Sur 37
  • 43 (a)
Sur 36
  • 18 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.6538 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 39 (a)
Species with no ortholog for ABCC12:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ABCC12 Gene

Gene Tree for ABCC12 (if available)
Gene Tree for ABCC12 (if available)

Paralogs for ABCC12 Gene

Paralogs for ABCC12 Gene

genes like me logo Genes that share paralogs with ABCC12: view

Variants for ABCC12 Gene

Sequence variations from dbSNP and Humsavar for ABCC12 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs16945901 - 48,146,400(+) TGAGA(G/T)AAGGT reference, missense
rs16945874 - 48,141,324(+) CCCTT(G/T)CTACC reference, missense
rs16945816 - 48,117,287(+) GAGGT(A/T)GCTCA reference, missense
rs8057474 - 48,104,361(+) GGCTC(A/T)TTAAG reference, missense
rs6500305 - 48,100,945(+) GTGGG(A/T)GAACC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for ABCC12 Gene

Variant ID Type Subtype PubMed ID
nsv520355 CNV Gain 19592680
esv2658965 CNV Deletion 23128226

Variation tolerance for ABCC12 Gene

Residual Variation Intolerance Score: 96.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.76; 89.43% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ABCC12 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ABCC12 Gene

Disorders for ABCC12 Gene

Relevant External Links for ABCC12

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ABCC12 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ABCC12 Gene

Publications for ABCC12 Gene

  1. Two new genes from the human ATP-binding cassette transporter superfamily, ABCC11 and ABCC12, tandemly duplicated on chromosome 16q12. (PMID: 11483364) Tammur J. … Allikmets R. (Gene 2001) 2 3 4 67
  2. MRP9, an unusual truncated member of the ABC transporter superfamily, is highly expressed in breast cancer. (PMID: 12011458) Bera T.K. … Pastan I. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 23
  3. The human ATP-binding cassette (ABC) transporter superfamily. (PMID: 11435397) Dean M. … Allikmets R. (Genome Res. 2001) 2 3
  4. Multiple splicing variants of two new human ATP-binding cassette transporters, ABCC11 and ABCC12. (PMID: 11688999) Yabuuchi H. … Ishikawa T. (Biochem. Biophys. Res. Commun. 2001) 3 23
  5. Genome-wide association study combining pathway analysis for typical sporadic amyotrophic lateral sclerosis in Chinese Han populations. (PMID: 24529757) Xie T. … Xu R. (Neurobiol. Aging 2014) 3

Products for ABCC12 Gene

Sources for ABCC12 Gene