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ABCC12 Gene

protein-coding   GIFtS: 56
GCID: GC16M048116

ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 12

  See ABCC12-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 121 2
MRP92 3 5
ATP-Binding Cassette Sub-Family C Member 122 3
ATP-Binding Cassette Transporter Sub-Family C Member 122
Multidrug Resistance-Associated Protein 92

External Ids:    HGNC: 146401   Entrez Gene: 941602   Ensembl: ENSG000001407987   OMIM: 6070415   UniProtKB: Q96J653   

Export aliases for ABCC12 gene to outside databases

Previous GC identifers: GC16M038531 GC16M048165 GC16M047854 GC16M047894 GC16M046674 GC16M034007


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ABCC12 Gene:
This gene is a member of the superfamily of ATP-binding cassette (ABC) transporters and the encoded protein
contains two ATP-binding domains and 12 transmembrane regions. ABC proteins transport various molecules across
extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies: ABC1, MDR/TAP, MRP,
ALD, OABP, GCN20, and White. This gene is a member of the MRP subfamily which is involved in multi-drug
resistance. This gene and another subfamily member are arranged head-to-tail on chromosome 16q12.1. Increased
expression of this gene is associated with breast cancer. (provided by RefSeq, Jul 2008)

GeneCards Summary for ABCC12 Gene:
ABCC12 (ATP-binding cassette, sub-family C (CFTR/MRP), member 12) is a protein-coding gene. Diseases associated with ABCC12 include dubin-johnson syndrome, and breast cancer. GO annotations related to this gene include ATPase activity, coupled to transmembrane movement of substances. An important paralog of this gene is ABCC4.

UniProtKB/Swiss-Prot: MRP9_HUMAN, Q96J65
Function: Probable transporter (By similarity)

Gene Wiki entry for ABCC12 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NC_018927.2  NT_010498.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the ABCC12 gene promoter:
         AhR   NF-1   NF-1/L   Spz1   AML1a   GATA-1   Gfi-1   AREB6   MEF-2A   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ABCC12 promoter sequence
   Search Chromatin IP Primers for ABCC12

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ABCC12


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q12.1   Ensembl cytogenetic band:  16q12.1   HGNC cytogenetic band: 16q12.1

ABCC12 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ABCC12 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M048116:  view genomic region     (about GC identifiers)

Start:
48,116,884 bp from pter      End:
48,189,929 bp from pter
Size:
73,046 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: MRP9_HUMAN, Q96J65 (See protein sequence)
Recommended Name: Multidrug resistance-associated protein 9  
Size: 1359 amino acids; 152297 Da
Developmental stage: Expressed in fetal tissues
Secondary accessions: Q49AL2 Q8TAF0 Q8TEY2
Alternative splicing: 5 isoforms:  Q96J65-1   Q96J65-2   Q96J65-3   Q96J65-4   Q96J65-5   (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for ABCC12: NX_Q96J65

Explore proteomics data for ABCC12 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn405, Asn438, Asn540, Asn981
  • Modification sites at PhosphoSitePlus

  • See ABCC12 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_150229.2  
    ENSEMBL proteins: 
     ENSP00000311030   ENSP00000431354   ENSP00000434510   ENSP00000431232   ENSP00000437047  
     ENSP00000433333   ENSP00000435715   ENSP00000436647   ENSP00000401855   ENSP00000413046  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ABCC: ATP binding cassette transporters / subfamily C

    IUPHAR Guide to PHARMACOLOGY protein family classification: ABCC12
    ABCC subfamily

    Selected InterPro protein domains (see all 6):
     IPR003439 ABC_transporter-like
     IPR027417 P-loop_NTPase
     IPR001140 ABC_transptr_TM_dom
     IPR003593 AAA+_ATPase
     IPR011527 ABC1_TM_dom

    Graphical View of Domain Structure for InterPro Entry Q96J65

    ProtoNet protein and cluster: Q96J65

    UniProtKB/Swiss-Prot: MRP9_HUMAN, Q96J65
    Similarity: Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208)
    subfamily
    Similarity: Contains 2 ABC transmembrane type-1 domains
    Similarity: Contains 2 ABC transporter domains


    Find genes that share domains with ABCC12           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MRP9_HUMAN, Q96J65
    Function: Probable transporter (By similarity)

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding ----
    GO:0005524ATP binding IEA--
    GO:0016887ATPase activity ----
    GO:0017111nucleoside-triphosphatase activity ----
    GO:0042626ATPase activity, coupled to transmembrane movement of substances IEA--
         
    Find genes that share ontologies with ABCC12           About GenesLikeMe


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Abcc12):
     no phenotypic analysis 

    Find genes that share phenotypes with ABCC12           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for ABCC12

    miRNA
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    hsa-miR-3163 hsa-miR-141 hsa-miR-205* hsa-miR-200a hsa-miR-616
    SwitchGear 3'UTR luciferase reporter plasmidABCC12 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MRP9_HUMAN, Q96J65: Membrane; Multi-pass membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3
    mitochondrion2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IEA--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with ABCC12           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ABCC12 About    
    See pathways by source

    SuperPathContained pathways About
    1ABC-family proteins mediated transport
    ABC transporters0.69


    Find genes that share SuperPaths with ABCC12           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Kegg Pathway  (Kegg details for ABCC12):
        ABC transporters

        Pathway & Disease-focused RT2 Profiler PCR Array including ABCC12: 
              Drug Transporters in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for ABCC12

    STRING Interaction Network Preview (showing 5 interactants - click image to see 23)

    Selected Interacting proteins for ABCC12 (Q96J653 ENSP000003110304) via UniProtKB, MINT, STRING, and/or I2D (see all 23)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    VCPIP1Q96JH73, ENSP000003090314I2D: score=2 STRING: ENSP00000309031
    MPIENSP000003183184STRING: ENSP00000318318
    PPP2R1AENSP000003248044STRING: ENSP00000324804
    PPP2R1BENSP000003113444STRING: ENSP00000311344
    ATP5A1ENSP000002820504STRING: ENSP00000282050
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport ----
    GO:0055085transmembrane transport ----

    Find genes that share ontologies with ABCC12           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ABCC12 (MRP9)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ABCC12 gene (5 alternative transcripts): 
    NM_033226.2  NM_145187.1  NM_145188.1  NM_145189.1  NM_145190.1  

    Unigene Cluster for ABCC12:

    ATP-binding cassette, sub-family C (CFTR/MRP), member 12
    Hs.410111  [show with all ESTs]
    Unigene Representative Sequence: AY040220
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000311303(uc002eey.1 uc002eez.1 uc002efa.1 uc002efb.1 uc002efc.1)
    ENST00000534418 ENST00000529084(uc002efd.1 uc010vgj.1) ENST00000497206
    ENST00000532494 ENST00000529504 ENST00000532355 ENST00000526251 ENST00000533185
    ENST00000528693(uc002efe.1) ENST00000533639 ENST00000527640 ENST00000448542
    ENST00000416054
    miRNA
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    hsa-miR-3163 hsa-miR-141 hsa-miR-205* hsa-miR-200a hsa-miR-616
    SwitchGear 3'UTR luciferase reporter plasmidABCC12 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AK122635.1 AK302520.1 AK307109.1 AK308599.1 AY040220.1 

    6 DOTS entries:

    DT.95099023  DT.101960525  DT.87014331  DT.97835594  DT.100749891  DT.91992476 

    20 AceView cDNA sequences:

    AY040220 NM_145187 AK127951 BC036378 AK122635 NM_033226 NM_145190 NM_145189 
    NM_145188 AY196326 AF395909 BX646798 AF411577 AA723717 AF411578 BG723063 
    AF395908 AW341683 CD637552 AA970140 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ABCC12 (see all 11)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20 ^
    SP1:                                                                                      -                                                                     
    SP2:                                                                                      -                             -                                       
    SP3:                                                                                      -                             -                                       
    SP4:                                                                                      -                             -                                       
    SP5:                                                                                      -                             -                                   -   

    ExUns: 21 ^ 22a · 22b ^ 23a · 23b ^ 24 ^ 25a · 25b · 25c ^ 26 ^ 27 ^ 28 ^ 29 ^ 30a · 30b · 30c
    SP1:        -           -                             -           -                                 
    SP2:                    -                             -           -                                 
    SP3:                    -                       -     -     -     -                                 
    SP4:                    -                             -     -     -                                 
    SP5:                    -                       -     -           -                                 


    ECgene alternative splicing isoforms for ABCC12

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ABCC12 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGAAAATGCC
    ABCC12 Expression
    About this image

    ABCC12 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ABCC12 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.410111

    UniProtKB/Swiss-Prot: MRP9_HUMAN, Q96J65
    Tissue specificity: Expressed in testis (at protein level). Widely expressed at low level. Isoform 5 is
    specifically expressed in brain, testis and breast cancer cells

        Pathway & Disease-focused RT2 Profiler PCR Array including ABCC12: 
              Drug Transporters in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ABCC12 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Abcc121 , 5 ATP-binding cassette, sub-family C (CFTR/MRP), member more1, 5 84.5(n)1
    85.46(a)1
      8 (42.06 cM)5
    2445621  NM_172912.41  NP_766500.31 
     864822605 
    lizard
    (Anolis carolinensis)
    Reptilia ABCC126
    ATP-binding cassette, sub-family C (CFTR/MRP), mem...
    59(a)
    1 ↔ 1
    LGc(2636674-2725866)
    zebrafish
    (Danio rerio)
    Actinopterygii abcc121 ATP-binding cassette, sub-family C (CFTR/MRP), member more 59.48(n)
    54.87(a)
      568482  XM_691812.4  XP_696904.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta Sur3 heart development sulfonylurea receptor 43(a)   31B1   --


    ENSEMBL Gene Tree for ABCC12 (if available)
    TreeFam Gene Tree for ABCC12 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ABCC12 gene
    ABCC42  ABCC12  ABCC82  ABCC52  ABCC62  ABCC32  ABCC22  ABCC92  
    ABCC112  
    Selected SIMAP similar genes for ABCC12 using alignment to 3 protein entries:     MRP9_HUMAN (see all proteins) (see all similar genes):
    ABCB4    DKFZp434I2115    ABCC11    ABCC5    CFTR    MOAT-B
    ABC-transporter    NG-TRA    ABCC4    ABCC2    DKFZp781G125    ABCG2
    ABCC1    ara    ABCC9    ABCC8    ABCC10    ABCC3

    Find genes that share paralogs with ABCC12           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ABCC12 (see all 1436)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs285601051,2
    C,F,H--48116409(+) TTCAGC/TGAGTT 1 -- ds50018Minor allele frequency- T:0.03NS NA WA 1002
    rs1862559621,2
    --48116425(+) GATGCG/TGTCAT 1 -- ds50010--------
    rs1902333091,2
    --48116627(+) GGGAAC/TCTCAT 1 -- ds50010--------
    rs744416551,2
    C,F--48116763(+) AGCGCT/CCACTC 1 -- ds50011Minor allele frequency- C:0.07WA 118
    rs761866591,2
    C,F--48116765(+) CGCTCA/GCTCCT 1 -- ds50011Minor allele frequency- G:0.05WA 118
    rs19783511,2
    C,F,H--48116874(-) CCTTCA/GCTCAG 1 -- ds50019Minor allele frequency- G:0.01MN NS EA NA 988
    rs1413438131,2
    --48116892(+) CAACAA/TGGGTC 1 -- ut310--------
    rs1423508751,2
    C--48116941(+) TGAAAA/TAATTG 1 -- ut310--------
    rs1141444171,2
    C,F--48116976(+) CCTACC/TGCGTT 1 -- ut311Minor allele frequency- T:0.03WA 118
    rs1812923751,2
    --48116977(+) CTACCA/GCGTTT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for ABCC12 (48116884 - 48189929 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for ABCC12:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2658965CNV Deletion23128226
    nsv520355CNV Gain19592680

    Human Gene Mutation Database (HGMD): ABCC12
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ABCC12
    DNA2.0 Custom Variant and Variant Library Synthesis for ABCC12

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607041    OMIM disorders: --

    2 diseases for ABCC12:    
    About MalaCards
    dubin-johnson syndrome    breast cancer

    1 disease from the University of Copenhagen DISEASES database for ABCC12:
    Dubin-Johnson syndrome

    Find genes that share disorders with ABCC12           About GenesLikeMe

    Genetic Association Database (GAD): ABCC12
    Human Genome Epidemiology (HuGE) Navigator: ABCC12 (2 documents)

    Export disorders for ABCC12 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ABCC12 gene, integrated from 10 sources (see all 16):
    (articles sorted by number of sources associating them with ABCC12)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Two new genes from the human ATP-binding cassette transporter superfamily, ABCC11 and ABCC12, tandemly duplicated on chromosome 16q12. (PubMed id 11483364)1, 2, 3 Tammur J.... Allikmets R. (Gene 2001)
    2. MRP9, an unusual truncated member of the ABC transporter superfamily, is highly expressed in breast cancer. (PubMed id 12011458)1, 2, 9 Bera T.K.... Pastan I. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    3. Multiple splicing variants of two new human ATP-binding cassette transporters, ABCC11 and ABCC12. (PubMed id 11688999)1, 2, 9 Yabuuchi H.... Ishikawa T. (Biochem. Biophys. Res. Commun. 2001)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    5. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. The human ATP-binding cassette (ABC) transporter superfamily. (PubMed id 11435397)1, 3 Dean M....Allikmets R. (Genome Res. 2001)
    8. Defining the human deubiquitinating enzyme interaction landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (Cell 2009)
    9. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    10. The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)2 Martin J.... Pennacchio L.A. (Nature 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 94160 HGNC: 14640 AceView: ABCC12 Ensembl:ENSG00000140798 euGenes: HUgn94160
    ECgene: ABCC12 Kegg: 94160 H-InvDB: ABCC12

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ABCC12 Pharmacogenomics, SNPs, Pathways
    ABCMdbhttp://abcmutations.hegelab.org/proteinDetails?uniprot_id=Q96J65

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ABCC12 gene:
    Search GeneIP for patents involving ABCC12

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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