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Aliases for ABCC11 Gene

Aliases for ABCC11 Gene

  • ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 11 2 3
  • MRP8 3 4 6
  • Multidrug Resistance-Associated Protein 8 3 4
  • EWWD 3 6
  • WW 3 6
  • ATP-Binding Cassette Transporter Sub-Family C Member 11 3
  • ATP-Binding Cassette Sub-Family C Member 11 3
  • ATP-Binding Cassette Transporter MRP8 3
  • ATP-Binding Cassette Protein C11 3
  • Multi-Resistance Protein 8 3

External Ids for ABCC11 Gene

Summaries for ABCC11 Gene

Entrez Gene Summary for ABCC11 Gene

  • The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This ABC full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. The product of this gene participates in physiological processes involving bile acids, conjugated steroids, and cyclic nucleotides. In addition, a SNP in this gene is responsible for determination of human earwax type. This gene and family member ABCC12 are determined to be derived by duplication and are both localized to chromosome 16q12.1. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for ABCC11 Gene

ABCC11 (ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 11) is a Protein Coding gene. Diseases associated with ABCC11 include dubin-johnson syndrome. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and ABC-family proteins mediated transport. GO annotations related to this gene include ATPase activity, coupled to transmembrane movement of substances. An important paralog of this gene is ABCC5.

UniProtKB/Swiss-Prot for ABCC11 Gene

  • Participates in physiological processes involving bile acids, conjugated steroids and cyclic nucleotides. Enhances the cellular extrusion of cAMP and cGMP. Stimulates the ATP-dependent uptake of a range of physiological and synthetic lipophilic anions, including the glutathione S-conjugates leukotriene C4 and dinitrophenyl S-glutathione, steroid sulfates such as dehydroepiandrosterone 3-sulfate (DHEAS) and estrone 3-sulfate, glucuronides such as estradiol 17-beta-D-glucuronide (E(2)17betaG), the monoanionic bile acids glycocholate and taurocholate, and methotrexate. Probably functions to secrete earwax.

Gene Wiki entry for ABCC11 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ABCC11 Gene

Genomics for ABCC11 Gene

Genomic Location for ABCC11 Gene

Start:
48,166,910 bp from pter
End:
48,247,568 bp from pter
Size:
80,659 bases
Orientation:
Minus strand

Genomic View for ABCC11 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ABCC11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ABCC11 Gene

Regulatory Elements for ABCC11 Gene

Transcription factor binding sites by QIAGEN in the ABCC11 gene promoter:

Proteins for ABCC11 Gene

  • Protein details for ABCC11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96J66-ABCCB_HUMAN
    Recommended name:
    ATP-binding cassette sub-family C member 11
    Protein Accession:
    Q96J66
    Secondary Accessions:
    • Q8TDJ0
    • Q96JA6
    • Q9BX80

    Protein attributes for ABCC11 Gene

    Size:
    1382 amino acids
    Molecular mass:
    154301 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ABCC11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ABCC11 Gene

Proteomics data for ABCC11 Gene at MOPED

Post-translational modifications for ABCC11 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn838, Asn844, and Asn992

Other Protein References for ABCC11 Gene

No data available for DME Specific Peptides for ABCC11 Gene

Domains for ABCC11 Gene

Gene Families for ABCC11 Gene

HGNC:
  • ABCC :ATP binding cassette transporters / subfamily C
IUPHAR :

Protein Domains for ABCC11 Gene

UniProtKB/Swiss-Prot:

ABCCB_HUMAN
Domain:
  • Contains 2 ABC transmembrane type-1 domains.:
    • Q96J66
  • Contains 2 ABC transporter domains.:
    • Q96J66
Family:
  • Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.:
    • Q96J66
genes like me logo Genes that share domains with ABCC11: view

Function for ABCC11 Gene

Molecular function for ABCC11 Gene

UniProtKB/Swiss-Prot Function: Participates in physiological processes involving bile acids, conjugated steroids and cyclic nucleotides. Enhances the cellular extrusion of cAMP and cGMP. Stimulates the ATP-dependent uptake of a range of physiological and synthetic lipophilic anions, including the glutathione S-conjugates leukotriene C4 and dinitrophenyl S-glutathione, steroid sulfates such as dehydroepiandrosterone 3-sulfate (DHEAS) and estrone 3-sulfate, glucuronides such as estradiol 17-beta-D-glucuronide (E(2)17betaG), the monoanionic bile acids glycocholate and taurocholate, and methotrexate. Probably functions to secrete earwax.

Gene Ontology (GO) - Molecular Function for ABCC11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
GO:0008514 organic anion transmembrane transporter activity IDA 15537867
GO:0015216 purine nucleotide transmembrane transporter activity IDA 12764137
GO:0016887 ATPase activity --
GO:0042626 ATPase activity, coupled to transmembrane movement of substances IEA --
genes like me logo Genes that share ontologies with ABCC11: view

miRNA for ABCC11 Gene

miRTarBase miRNAs that target ABCC11

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ABCC11 Gene

Localization for ABCC11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ABCC11 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ABCC11 Gene COMPARTMENTS Subcellular localization image for ABCC11 gene
Compartment Confidence
plasma membrane 4
endoplasmic reticulum 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for ABCC11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IDA 16359813
GO:0016021 integral component of membrane --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with ABCC11: view

Pathways for ABCC11 Gene

genes like me logo Genes that share pathways with ABCC11: view

Pathways by source for ABCC11 Gene

1 KEGG pathway for ABCC11 Gene

Interacting Proteins for ABCC11 Gene

Gene Ontology (GO) - Biological Process for ABCC11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006200 obsolete ATP catabolic process --
GO:0006810 transport --
GO:0008152 metabolic process IEA --
GO:0015711 organic anion transport IDA 15537867
GO:0015865 purine nucleotide transport IDA 12764137
genes like me logo Genes that share ontologies with ABCC11: view

Compounds for ABCC11 Gene

(1) HMDB Compounds for ABCC11 Gene

Compound Synonyms Cas Number PubMed IDs
Cyclic AMP
  • Cyclic AMP
60-92-4

(7) Drugbank Compounds for ABCC11 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Conjugated Estrogens
  • Estrogens
438-67-5 transporter substrate
Cyclic Adenosine Monophosphate
  • 3'-5'-cyclic adenosine monophosphate
60-92-4 transporter substrate inhibitor
Folic Acid
  • Folate
59-30-3 transporter substrate
Indomethacin
  • IMN
53-86-1 transporter inhibitor
Methotrexate
  • Amethopterin
59-05-2 transporter substrate

(6) Novoseek inferred chemical compound relationships for ABCC11 Gene

Compound -log(P) Hits PubMed IDs
adefovir 51 3
5fluorouracil 49.9 8
methotrexate 46.1 6
dehydroepiandrosterone sulfate 40 3
dhea 34.8 3

(1) PharmGKB related drug/compound annotations for ABCC11 Gene

Drug/compound Annotation
fluorouracil CA
genes like me logo Genes that share compounds with ABCC11: view

Transcripts for ABCC11 Gene

Unigene Clusters for ABCC11 Gene

ATP-binding cassette, sub-family C (CFTR/MRP), member 11:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ABCC11 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22a · 22b ^ 23 ^
SP1: - -
SP2: - -
SP3: -
SP4:
SP5:

ExUns: 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32
SP1: -
SP2: - -
SP3: -
SP4:
SP5:

Relevant External Links for ABCC11 Gene

GeneLoc Exon Structure for
ABCC11
ECgene alternative splicing isoforms for
ABCC11

Expression for ABCC11 Gene

mRNA expression in normal human tissues for ABCC11 Gene

mRNA differential expression in normal tissues according to GTEx for ABCC11 Gene

This gene is overexpressed in Liver (11.0), Testis (8.2), and Breast - Mammary Tissue (7.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ABCC11 Gene

SOURCE GeneReport for Unigene cluster for ABCC11 Gene Hs.652267

mRNA Expression by UniProt/SwissProt for ABCC11 Gene

Q96J66-ABCCB_HUMAN
Tissue specificity: Expressed in many tissues. Not expressed in kidney, spleen and colon. Highly expressed in breast cancer. Expressed at moderate levels in normal breast and testis and at very low levels in liver, brain and placenta.
genes like me logo Genes that share expressions with ABCC11: view

Orthologs for ABCC11 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ABCC11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ABCC11 36
  • 99.06 (n)
  • 98.77 (a)
ABCC11 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ABCC11 37
  • 67 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ABCC11 36
  • 81.44 (n)
  • 75.49 (a)
ABCC11 37
  • 75 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ABCC11 37
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ABCC11 37
  • 56 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii abcc12 37
  • 47 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Sur 37
  • 16 (a)
OneToMany
Sur 38
  • 41 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.10235 36
wheat
(Triticum aestivum)
Liliopsida Ta.27443 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 36 (a)
OneToMany
Species with no ortholog for ABCC11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • worm (Caenorhabditis elegans)

Evolution for ABCC11 Gene

ENSEMBL:
Gene Tree for ABCC11 (if available)
TreeFam:
Gene Tree for ABCC11 (if available)

Paralogs for ABCC11 Gene

Paralogs for ABCC11 Gene

genes like me logo Genes that share paralogs with ABCC11: view

Variants for ABCC11 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for ABCC11 Gene

Q96J66-ABCCB_HUMAN
The allele with Arg-184 is responsible for the dry earwax phenotype [MIM:117800]. Human earwax is a Mendelian trait consisting of wet and dry types. The wet earwax is brownish and sticky, whereas the dry type lacks cerumen. The wet cerumen phenotype is completely dominant. The dry type is seen frequently (80-95%) among East Asians, but uncommon (0-3%) in populations of European and African origins. Intermediate frequencies (30-50%) of the dry type are seen in populations of Southern Asia, the Pacific Islands, Central Asia and Asia Minor, as well as among the Native North American and Inuit of Asian ancestry

Sequence variations from dbSNP and Humsavar for ABCC11 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs1075589 -- 48,222,994(+) GTCCA(G/T)TTGGA intron-variant
rs1468868 -- 48,234,342(-) ttaca(A/T)caaaa intron-variant
rs4396534 -- 48,197,309(+) ACGGA(C/G)CAAAC intron-variant
rs4430735 -- 48,223,782(+) TCCCA(A/T)CCATG intron-variant
rs4785509 -- 48,228,988(+) AAAGA(C/T)GGGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ABCC11 Gene

Variant ID Type Subtype PubMed ID
nsv827641 CNV Gain 20364138

Relevant External Links for ABCC11 Gene

HapMap Linkage Disequilibrium report
ABCC11
Human Gene Mutation Database (HGMD)
ABCC11

Disorders for ABCC11 Gene

(1) OMIM Diseases for ABCC11 Gene (607040)

(1) MalaCards Diseases for ABCC11 Gene

Search for ABCC11 Gene in MalaCards »

(1) University of Copenhagen DISEASES for ABCC11 Gene

(1) Novoseek inferred disease relationships for ABCC11 Gene

Disease -log(P) Hits PubMed IDs
breast cancer 19.2 9

Relevant External Links for ABCC11

Genetic Association Database (GAD)
ABCC11
Human Genome Epidemiology (HuGE) Navigator
ABCC11
genes like me logo Genes that share disorders with ABCC11: view

No data available for UniProtKB/Swiss-Prot for ABCC11 Gene

Publications for ABCC11 Gene

  1. Two new genes from the human ATP-binding cassette transporter superfamily, ABCC11 and ABCC12, tandemly duplicated on chromosome 16q12. (PMID: 11483364) Tammur J. … Allikmets R. (Gene 2001) 2 3 4 23
  2. MRP8, ATP-binding cassette C11 (ABCC11), is a cyclic nucleotide efflux pump and a resistance factor for fluoropyrimidines 2',3'- dideoxycytidine and 9'-(2'-phosphonylmethoxyethyl)adenine. (PMID: 12764137) Guo Y. … Kruh G.D. (J. Biol. Chem. 2003) 3 4 23 25
  3. Transport of bile acids, sulfated steroids, estradiol 17-beta-D- glucuronide, and leukotriene C4 by human multidrug resistance protein 8 (ABCC11). (PMID: 15537867) Chen Z.S. … Kruh G.D. (Mol. Pharmacol. 2005) 3 4 23 25
  4. MRP8, a new member of ABC transporter superfamily, identified by EST database mining and gene prediction program, is highly expressed in breast cancer. (PMID: 11591886) Bera T.K. … Pastan I.H. (Mol. Med. 2001) 3 4 23
  5. Multiple splicing variants of two new human ATP-binding cassette transporters, ABCC11 and ABCC12. (PMID: 11688999) Yabuuchi H. … Ishikawa T. (Biochem. Biophys. Res. Commun. 2001) 3 4 23

Products for ABCC11 Gene

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Drug Transporters in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate ABCC11
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for ABCC11
    • Block miRNA regulation of ABCC11 using miScript Target Protectors

    Sources for ABCC11 Gene

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