Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



ABCC11 Gene

protein-coding   GIFtS: 62
GCID: GC16M048249

ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 11

  See ABCC11-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 111 2     ATP-Binding Cassette Protein C112
MRP82 3 5     ATP-Binding Cassette Sub-Family C Member 112
Multidrug Resistance-Associated Protein 82 3     ATP-Binding Cassette Transporter MRP82
EWWD2 5     ATP-Binding Cassette Transporter Sub-Family C Member 112
WW2 5     Multi-Resistance Protein 82

External Ids:    HGNC: 146391   Entrez Gene: 853202   Ensembl: ENSG000001212707   OMIM: 6070405   UniProtKB: Q96J663   

Export aliases for ABCC11 gene to outside databases

Previous GC identifers: GC16M038615 GC16M047938 GC16M047978 GC16M046758 GC16M034090


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for ABCC11 Gene:
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC
proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven
distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This ABC full transporter is a member of the
MRP subfamily which is involved in multi-drug resistance. The product of this gene participates in physiological
processes involving bile acids, conjugated steroids, and cyclic nucleotides. In addition, a SNP in this gene is
responsible for determination of human earwax type. This gene and family member ABCC12 are determined to be
derived by duplication and are both localized to chromosome 16q12.1. Multiple alternatively spliced transcript
variants have been described for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for ABCC11 Gene:
ABCC11 (ATP-binding cassette, sub-family C (CFTR/MRP), member 11) is a protein-coding gene. Diseases associated with ABCC11 include dubin-johnson syndrome. GO annotations related to this gene include ATPase activity, coupled to transmembrane movement of substances. An important paralog of this gene is ABCC4.

UniProtKB/Swiss-Prot: ABCCB_HUMAN, Q96J66
Function: Participates in physiological processes involving bile acids, conjugated steroids and cyclic
nucleotides. Enhances the cellular extrusion of cAMP and cGMP. Stimulates the ATP-dependent uptake of a range of
physiological and synthetic lipophilic anions, including the glutathione S-conjugates leukotriene C4 and
dinitrophenyl S-glutathione, steroid sulfates such as dehydroepiandrosterone 3-sulfate (DHEAS) and estrone
3-sulfate, glucuronides such as estradiol 17-beta-D-glucuronide (E(2)17betaG), the monoanionic bile acids
glycocholate and taurocholate, and methotrexate. Probably functions to secrete earwax

Gene Wiki entry for ABCC11 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NC_018927.2  NT_010498.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the ABCC11 gene promoter:
         ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ABCC11 promoter sequence
   Search Chromatin IP Primers for ABCC11

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ABCC11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q12.1   Ensembl cytogenetic band:  16q12.1   HGNC cytogenetic band: 16q12

ABCC11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ABCC11 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M048249:  view genomic region     (about GC identifiers)

Start:
48,200,821 bp from pter      End:
48,281,479 bp from pter
Size:
80,659 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: ABCCB_HUMAN, Q96J66 (See protein sequence)
Recommended Name: ATP-binding cassette sub-family C member 11  
Size: 1382 amino acids; 154301 Da
Secondary accessions: Q8TDJ0 Q96JA6 Q9BX80
Alternative splicing: 2 isoforms:  Q96J66-1   Q96J66-2   

Explore the universe of human proteins at neXtProt for ABCC11: NX_Q96J66

Explore proteomics data for ABCC11 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn838, Asn844, Asn992
  • Modification sites at PhosphoSitePlus

  • See ABCC11 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_115972.2  NP_149163.2  NP_660187.1  

    ENSEMBL proteins: 
     ENSP00000311326   ENSP00000349017   ENSP00000378230   ENSP00000456268   ENSP00000378231  
     ENSP00000438530  
    Reactome Protein details: Q96J66

    ABCC11 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for ABCC11
    GenScript Custom Purified and Recombinant Proteins Services for ABCC11
    Novus Biologicals ABCC11 Proteins
    Novus Biologicals ABCC11 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ABCC11

     
    Search eBioscience for Proteins for ABCC11 

     
    antibodies-online proteins for ABCC11 (3 products) 

     
    antibodies-online peptides for ABCC11

    ABCC11 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for ABCC11
    OriGene Custom Antibody Services for ABCC11
    Novus Biologicals ABCC11 Antibodies
    Abcam antibodies for ABCC11
    Cloud-Clone Corp. Antibodies for ABCC11
    ThermoFisher Antibodies for ABCC11
    antibodies-online antibodies for ABCC11 (35 products) 

    ABCC11 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ABCC11
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ABCC11
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ABCC11
    Cloud-Clone Corp. CLIAs for ABCC11
    Search eBioscience for ELISAs for ABCC11 
    antibodies-online kits for ABCC11 (2 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    ABCC: ATP binding cassette transporters / subfamily C

    IUPHAR Guide to PHARMACOLOGY protein family classification: ABCC11
    ABCC subfamily

    Selected InterPro protein domains (see all 6):
     IPR003439 ABC_transporter-like
     IPR027417 P-loop_NTPase
     IPR001140 ABC_transptr_TM_dom
     IPR003593 AAA+_ATPase
     IPR011527 ABC1_TM_dom

    Graphical View of Domain Structure for InterPro Entry Q96J66

    ProtoNet protein and cluster: Q96J66

    UniProtKB/Swiss-Prot: ABCCB_HUMAN, Q96J66
    Similarity: Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208)
    subfamily
    Similarity: Contains 2 ABC transmembrane type-1 domains
    Similarity: Contains 2 ABC transporter domains


    Find genes that share domains with ABCC11           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ABCCB_HUMAN, Q96J66
    Function: Participates in physiological processes involving bile acids, conjugated steroids and cyclic
    nucleotides. Enhances the cellular extrusion of cAMP and cGMP. Stimulates the ATP-dependent uptake of a range of
    physiological and synthetic lipophilic anions, including the glutathione S-conjugates leukotriene C4 and
    dinitrophenyl S-glutathione, steroid sulfates such as dehydroepiandrosterone 3-sulfate (DHEAS) and estrone
    3-sulfate, glucuronides such as estradiol 17-beta-D-glucuronide (E(2)17betaG), the monoanionic bile acids
    glycocholate and taurocholate, and methotrexate. Probably functions to secrete earwax

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding ----
    GO:0005524ATP binding IEA--
    GO:0008514organic anion transmembrane transporter activity IDA15537867
    GO:0015216purine nucleotide transmembrane transporter activity IDA12764137
    GO:0016887ATPase activity ----
         
    Find genes that share ontologies with ABCC11           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for ABCC11

    miRNA
    Products:
        
    miRTarBase miRNAs that target ABCC11:
    hsa-mir-335-5p (MIRT016799)

    Block miRNA regulation of human, mouse, rat ABCC11 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate ABCC11
    SwitchGear 3'UTR luciferase reporter plasmidABCC11 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ABCC11
    Predesigned siRNA for gene silencing in human, mouse, rat ABCC11

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ABCC11

    Clone
    Products:
         
    OriGene clones in human, mouse for ABCC11 (see all 16)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): ABCC11 (NM_033151)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ABCC11
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ABCC11

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ABCC11
    Browse ESI BIO Cell Lines and PureStem Progenitors for ABCC11 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ABCC11


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    ABCCB_HUMAN, Q96J66: Membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    endoplasmic reticulum1
    mitochondrion1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane IDA16359813
    GO:0016021integral component of membrane ----
    GO:0070062extracellular vesicular exosome IDA19056867

    Find genes that share ontologies with ABCC11           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for ABCC11 About    
    See pathways by source

    SuperPathContained pathways About
    1ABC-family proteins mediated transport
    ABC-family proteins mediated transport0.69
    ABC transporters0.69
    2Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    Transmembrane transport of small molecules0.47


    Find genes that share SuperPaths with ABCC11           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for ABCC11
        ABC-family proteins mediated transport


    1 Kegg Pathway  (Kegg details for ABCC11):
        ABC transporters

        Pathway & Disease-focused RT2 Profiler PCR Array including ABCC11: 
              Drug Transporters in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for ABCC11

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for ABCC11 (ENSP000003490174) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ABCB6ENSP000002653164STRING: ENSP00000265316
    ABCB7ENSP000002535774STRING: ENSP00000253577
    ABCG2ENSP000002376124STRING: ENSP00000237612
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport ----
    GO:0015711organic anion transport IDA15537867
    GO:0015865purine nucleotide transport IDA12764137
    GO:0055085transmembrane transport TAS--

    Find genes that share ontologies with ABCC11           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ABCC11 (ABCCB)

    1 HMDB Compound for ABCC11    About this table
    CompoundSynonyms CAS #PubMed Ids
    Cyclic AMPCyclic AMP (see all 19)60-92-4--

    7 DrugBank Compounds for ABCC11    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Cyclic Adenosine Monophosphate3'-5'-cyclic adenosine monophosphate (see all 5)60-92-4transportersubstrate inhibitor15537867 12764137
    Conjugated EstrogensEstrogens (see all 10)438-67-5transportersubstrate15537867
    Folic AcidFolate (see all 9)59-30-3transportersubstrate15537867
    IndomethacinIMN (see all 9)53-86-1transporterinhibitor15537867
    MethotrexateAmethopterin (see all 12)59-05-2transportersubstrate15537867
    Probenecid-- 57-66-9transporterinhibitor15537867
    Taurocholic Acid-- 81-24-3transporterinhibitor15537867

    6 Novoseek inferred chemical compound relationships for ABCC11 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    adefovir 51 4 12764137 (2), 16868766 (1)
    5fluorouracil 49.9 16 17237272 (4), 18310281 (2), 12764137 (1), 17216005 (1)
    methotrexate 46.1 12 17237272 (2), 19248091 (1), 18310281 (1), 15537867 (1) (see all 5)
    dehydroepiandrosterone sulfate 40 5 16359813 (2), 15537867 (1)
    dhea 34.8 5 16868766 (2), 16359813 (1)
    iron 0 2 16410366 (1), 8336670 (1)

    1 PharmGKB related drug/compound annotation for ABCC11 gene    About this table
    Drug/compound PharmGKB Annotation
    fluorouracilCA  



    Find genes that share compounds with ABCC11           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for ABCC11 gene (3 alternative transcripts): 
    NM_032583.3  NM_033151.3  NM_145186.2  

    Unigene Cluster for ABCC11:

    ATP-binding cassette, sub-family C (CFTR/MRP), member 11
    Hs.652267  [show with all ESTs]
    Unigene Representative Sequence: AY040219
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000565329(uc010cbg.1) ENST00000353782(uc010vgk.1 uc002efh.1)
    ENST00000356608 ENST00000394747(uc002eff.1) ENST00000569172 ENST00000567385
    ENST00000565487 ENST00000569991 ENST00000394748(uc002efg.1) ENST00000537808(uc010vgl.1)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ABCC11 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate ABCC11
    SwitchGear 3'UTR luciferase reporter plasmidABCC11 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ABCC11
    Predesigned siRNA for gene silencing in human, mouse, rat ABCC11
    Clone
    Products:
         
    OriGene clones in human, mouse for ABCC11 (see all 16)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): ABCC11 (NM_033151)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ABCC11
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ABCC11
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for ABCC11
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat ABCC11
      QuantiTect SYBR Green Assays in human, mouse, rat ABCC11
      QuantiFast Probe-based Assays in human, mouse, rat ABCC11

    Additional mRNA sequence: 

    AF352582.1 AF367202.1 AF411579.1 AK301547.1 AL117406.1 AY040219.1 

    9 DOTS entries:

    DT.86846741  DT.97824116  DT.95249093  DT.97771477  DT.120721587  DT.97824115  DT.120721493  DT.120721449 
    DT.442910 

    Selected AceView cDNA sequences (see all 26):

    AL117406 NM_033151 NM_032583 BF447217 BF924908 AY040219 NM_145186 BC039085 
    AF411579 AF352582 AA412392 AF367202 BE869517 T81803 BI462847 W94983 
    BE089591 AI676121 AI401832 BF760362 AW372855 AW372856 T82135 CD634784 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for ABCC11    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22a · 22b ^ 23 ^
    SP1:        -                             -                                                                                                                     
    SP2:        -                             -                                                                                                                     
    SP3:                                      -                                                                                                                     
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32
    SP1:                    -                                 
    SP2:                    -                 -               
    SP3:                    -                                 
    SP4:                                                      
    SP5:                                                      


    ECgene alternative splicing isoforms for ABCC11

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    ABCC11 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGAATAATT
    ABCC11 Expression
    About this image

    ABCC11 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ABCC11 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.652267

    UniProtKB/Swiss-Prot: ABCCB_HUMAN, Q96J66
    Tissue specificity: Expressed in many tissues. Not expressed in kidney, spleen and colon. Highly expressed in
    breast cancer. Expressed at moderate levels in normal breast and testis and at very low levels in liver, brain
    and placenta

        Pathway & Disease-focused RT2 Profiler PCR Array including ABCC11: 
              Drug Transporters in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for ABCC11
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat ABCC11
    QuantiTect SYBR Green Assays in human, mouse, rat ABCC11
    QuantiFast Probe-based Assays in human, mouse, rat ABCC11
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ABCC11

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ABCC11 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia ABCC111 ATP-binding cassette, sub-family C (CFTR/MRP), member more 81.44(n)
    75.49(a)
      100856571  XM_003638934.2  XP_003638982.1 
    zebrafish
    (Danio rerio)
    Actinopterygii abcc126
    ATP-binding cassette, sub-family C (CFTR/MRP), mem...
    47(a)
    1 → many
    7(39550710-39575433) ENSDARG00000013050
    fruit fly
    (Drosophila melanogaster)
    Insecta Sur3 heart development sulfonylurea receptor 41(a)   31B1   --
    barley
    (Hordeum vulgare)
    Liliopsida Hv.102352 Transcribed sequence with moderate similarity to protein more 67.69(n)    BQ469119.1 


    ENSEMBL Gene Tree for ABCC11 (if available)
    TreeFam Gene Tree for ABCC11 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for ABCC11 gene
    ABCC42  ABCC32  ABCC122  ABCC62  ABCC12  ABCC22  ABCC82  ABCC52  
    ABCC92  
    Selected SIMAP similar genes for ABCC11 using alignment to 3 protein entries:     ABCCB_HUMAN (see all proteins) (see all similar genes):
    ABCC12    ABCB4    CFTR    TAP1    MOAT-B    DKFZp434I2115
    ABCC5    NG-TRA    ABC-transporter    ABCC2    ABCC4    ABCG2
    DKFZp781G125    ABCC9    ABCC1    ABCC3    ABCC8    MRP3

    Find genes that share paralogs with ABCC11           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Polymorphic Variants from UniProtKB/Swiss-Prot
    ABCCB_HUMAN, Q96J66: The allele with Arg-184 is responsible for the dry earwax phenotype [MIM:117800]. Human earwax is a
    Mendelian trait consisting of wet and dry types. The wet earwax is brownish and sticky, whereas the dry type
    lacks cerumen. The wet cerumen phenotype is completely dominant. The dry type is seen frequently (80-95%) among
    East Asians, but uncommon (0-3%) in populations of European and African origins. Intermediate frequencies
    (30-50%) of the dry type are seen in populations of Southern Asia, the Pacific Islands, Central Asia and Asia
    Minor, as well as among the Native North American and Inuit of Asian ancestry


    Selected SNPs for ABCC11 (see all 1605)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs178229311,2,,4
    C,F,Hpathogenic149273499(+) TGGCCC/TGAGTA 6 R G mis1 ese337Minor allele frequency- T:0.20NA NS MN EA WA EU 10919
    rs1426196031,2
    C,F--48200732(+) GATTGC/AGCCAC 3 -- ds50011Minor allele frequency- A:0.06--542
    rs620585201,2
    C,F--48202847(+) CTTAAT/CGCATG 3 -- int13Minor allele frequency- C:0.12NA 124
    rs1114593171,2
    C,F--48203550(+) GAAACT/CATCAC 3 -- int12Minor allele frequency- C:0.00CSA 2
    rs606010391,2
    C--48223345(+) TTTTT-/TCTGTT 3 -- int10--------
    rs1127623191,2
    F--48225752(+) GGGGGT/ACGGGG 3 -- int12Minor allele frequency- A:0.00CSA 2
    rs612470321,2
    C--48231223(+) ACCAAG/-ACTCT 3 -- int12Minor allele frequency- -:0.00NA CSA 4
    rs673593261,2
    C--48231224(+) CCAAA-/GCTCTG 3 -- int10--------
    rs58165891,2
    C--48239723(+) ttttt-/T/TT  
            
    ttttt
    3 -- int1 trp30--------
    rs713902631,2
    C--48241770(-) TCTGGCAGT    
       GGG
    /-
    GTACC
    3 -- int11Minor allele frequency- -:0.50NA 2

    HapMap Linkage Disequilibrium report for ABCC11 (48200821 - 48281479 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ABCC11:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv827641CNV Gain20364138

    Human Gene Mutation Database (HGMD): ABCC11
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ABCC11
    DNA2.0 Custom Variant and Variant Library Synthesis for ABCC11

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 607040   
    OMIM disorders: 117800  
    1 disease for ABCC11:    
    About MalaCards
    dubin-johnson syndrome

    1 disease from the University of Copenhagen DISEASES database for ABCC11:
    Dubin-Johnson syndrome

    Find genes that share disorders with ABCC11           About GenesLikeMe

    1 Novoseek inferred disease relationship for ABCC11 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    breast cancer 19.2 2 18310281 (5), 11591886 (2), 19383836 (1), 19248091 (1)

    Genetic Association Database (GAD): ABCC11
    Human Genome Epidemiology (HuGE) Navigator: ABCC11 (6 documents)

    Export disorders for ABCC11 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for ABCC11 gene, integrated from 10 sources (see all 62):
    (articles sorted by number of sources associating them with ABCC11)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. MRP8, ATP-binding cassette C11 (ABCC11), is a cyclic nucleotide efflux pump and a resistance factor for fluoropyrimidines 2',3'- dideoxycytidine and 9'-(2'-phosphonylmethoxyethyl)adenine. (PubMed id 12764137)1, 2, 7, 9 Guo Y....Kruh G.D. (J. Biol. Chem. 2003)
    2. Transport of bile acids, sulfated steroids, estradiol 17-beta-D- glucuronide, and leukotriene C4 by human multidrug resistance protein 8 (ABCC11). (PubMed id 15537867)1, 2, 7, 9 Chen Z.S.... Kruh G.D. (Mol. Pharmacol. 2005)
    3. Two new genes from the human ATP-binding cassette transporter superfamily, ABCC11 and ABCC12, tandemly duplicated on chromosome 16q12. (PubMed id 11483364)1, 2, 3, 9 Tammur J.... Allikmets R. (Gene 2001)
    4. Multiple splicing variants of two new human ATP-binding cassette transporters, ABCC11 and ABCC12. (PubMed id 11688999)1, 2, 9 Yabuuchi H.... Ishikawa T. (Biochem. Biophys. Res. Commun. 2001)
    5. MRP8, a new member of ABC transporter superfamily, identified by EST database mining and gene prediction program, is highly expressed in breast cancer. (PubMed id 11591886)1, 2, 9 Bera T.K.... Pastan I.H. (Mol. Med. 2001)
    6. A strong association of axillary osmidrosis with the wet earwax type determined by genotyping of the ABCC11 gene. (PubMed id 19650936)1, 4, 9 Nakano M....Niikawa N. (BMC Genet. 2009)
    7. A SNP in the ABCC11 gene is the determinant of human earwax type. (PubMed id 16444273)1, 2, 9 Yoshiura K.... Niikawa N. (Nat. Genet. 2006)
    8. Japanese map of the earwax gene frequency: a nationwide collaborative study by Super Science High School Consortium. (PubMed id 19644513)1, 4, 9 (J. Hum. Genet. 2009)
    9. Correlation of axillary osmidrosis to a SNP in the ABCC11 gene determined by the Smart Amplification Process (SmartAmp) method. (PubMed id 19625231)1, 4 Inoue Y....Sakai Y. (amp 2010)
    10. Association between breast cancer risk and the wild-type allele of human ABC transporter ABCC11. (PubMed id 21187511)1, 4 Ota I....Shimada H. (Anticancer Res. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 85320 HGNC: 14639 AceView: ABCC11 Ensembl:ENSG00000121270 euGenes: HUgn85320
    ECgene: ABCC11 Kegg: 85320 H-InvDB: ABCC11

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for ABCC11 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ABCC11 Genetics and Cytogenetics in Oncology and Haematology
    Protein Spotlighthttp://web.expasy.org/spotlight/back_issues/067
    ABCMdbhttp://abcmutations.hegelab.org/proteinDetails?uniprot_id=Q96J66

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for ABCC11 gene:
    Search GeneIP for patents involving ABCC11

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for ABCC11   OriGene RNAi products in human, mouse, rat for ABCC11  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for ABCC11  
     OriGene qSTAR qPCR primer pairs in human, mouse for ABCC11   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     Browse OriGene ORF clones   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ABCC11   OriGene Custom Protein Services for ABCC11  

     
     
     Block miRNA regulation of human, mouse, rat ABCC11 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing ABCC11
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ABCC11 Predesigned siRNA for gene silencing in human, mouse, rat ABCC11
     QuantiFast Probe-based Assays in human, mouse, rat ABCC11 QuantiTect SYBR Green Assays in human, mouse, rat ABCC11
     PCR Arrays including human, mouse, rat ABCC11 Search Chromatin IP Primers for ABCC11
     Pre-validated RT2 qPCR Primer Assay in human, mouse / rat ABCC11  Search GeneGlobe Interaction Network for ABCC11
     Regulatory tfbs in ABCC11 promoter
     GenScript Custom Purified and Recombinant Proteins Services for ABCC11 GenScript cDNA clones with any tag delivered in your preferred vector for ABCC11
     GenScript Custom Assay Services for ABCC11 GenScript Custom overexpressing Cell Line Services for ABCC11
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for ABCC11 (ABCCB)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     ABCC11 antibodies
     ABCC11 proteins
     ABCC11 lysates
     Antibodies for ABCC11
     See all of Abcam's Antibodies, Kits and Proteins for ABCC11
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for ABCC11
     Antibodies for ABCC11
     ELISAs for ABCC11
     CLIAs for ABCC11



     Browse ESI BIO Cell Lines and PureStem Progenitors for ABCC11
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ABCC11
     SwitchGear 3'UTR luciferase reporter plasmids for ABCC11
     SwitchGear Promoter luciferase reporter plasmids for ABCC11
     ThermoFisher Antibodies for ABCC11
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ABCC11
     Browse compounds at ApexBio
     Search Addgene for plasmids for ABCC11
      Search eBioscience for proteins for ABCC11
      Search eBioscience for elisas for ABCC11
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for ABCC11
     antibodies-online antibodies for ABCC11 (35 products)
     antibodies-online kits for ABCC11 (2 products)
     antibodies-online peptides for ABCC11
     antibodies-online proteins for ABCC11 (3 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      ABCC11 gene at Home site.
    Version: 3.12.258 10 Dec 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4