ABCC11 Gene
protein-coding GIFtS: 56
GCID: GC16M048249
|
|
ATP-binding cassette, sub-family C (CFTR/MRP), member 11
| |
Aliases
for ABCC11 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 111 2 | | ATP-Binding Cassette Protein C112 | | MRP81 2 3 5 | | ATP-Binding Cassette Sub-Family C Member 112 | | Multidrug Resistance-Associated Protein 82 3 | | ATP-Binding Cassette Transporter MRP82 | | EWWD2 5 | | ATP-Binding Cassette Transporter Sub-Family C Member 112 | | WW2 5 | | Multi-Resistance Protein 82 |
Export aliases for ABCC11 gene to outside databasesPrevious GC identifers: GC16M038615 GC16M047938 GC16M047978 GC16M046758 GC16M034090 |
Summaries
for ABCC11 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for ABCC11:
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABCproteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into sevendistinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This ABC full transporter is a member of the MRPsubfamily which is involved in multi-drug resistance. The product of this gene participates in physiological processesinvolving bile acids, conjugated steroids, and cyclic nucleotides. In addition, a SNP in this gene is responsible fordetermination of human earwax type. This gene and family member ABCC12 are determined to be derived by duplication andare both localized to chromosome 16q12.1. Multiple alternatively spliced transcript variants have been described forthis gene. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: ABCCB_HUMAN, Q96J66Function: Participates in physiological processes involving bile acids, conjugated steroids and cyclic nucleotides.Enhances the cellular extrusion of cAMP and cGMP. Stimulates the ATP-dependent uptake of a range of physiological andsynthetic lipophilic anions, including the glutathione S-conjugates leukotriene C4 and dinitrophenyl S-glutathione,steroid sulfates such as dehydroepiandrosterone 3-sulfate (DHEAS) and estrone 3-sulfate, glucuronides such asestradiol 17-beta-D-glucuronide (E(2)17betaG), the monoanionic bile acids glycocholate and taurocholate, andmethotrexate. Probably functions to secrete earwax
Gene Wiki entry for ABCC11
|
Genomic Views
for ABCC11 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000016.9 NC_018927.1 NT_010498.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ABCC11 gene promoter:
ATF-2 c-Jun
Other transcription factors
Search SABiosciences Chromatin IP Primers for ABCC11
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ABCC11 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 16q12.1 Ensembl cytogenetic band: 16q12.1 HGNC cytogenetic band: 16q12ABCC11 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16M048249: view genomic region
(about GC identifiers)
Start:
|
48,200,821 bp from pter |
End:
|
48,281,479 bp from pter |
Size:
|
80,659 bases |
Orientation:
|
minus strand |
|
Proteins
for ABCC11 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ABCCB_HUMAN, Q96J66 (See
protein sequence)Recommended Name: ATP-binding cassette sub-family C member 11 Size: 1382 amino acids; 154301 Da
Subcellular location: Membrane; Multi-pass membrane protein
Secondary accessions: Q8TDJ0 Q96JA6 Q9BX80Alternative splicing: 2 isoforms: Q96J66-1 Q96J66-2 Explore the universe of human proteins at neXtProt for ABCC11: NX_Q96J66
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96J66
ABCC11 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_115972.2 NP_149163.2 NP_660187.1
ENSEMBL proteins: ENSP00000311326 ENSP00000349017 ENSP00000378230 ENSP00000456268 ENSP00000378231 ENSP00000438530 Reactome Protein details: Q96J66
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005886 | plasma membrane |
TAS | -- | | GO:0016021 | integral to membrane |
IEA | -- |
ABCC11 for ontologies About GeneDecksing
ABCC11 Antibody Products:
Assay Products for ABCC11: |
Protein
Domains /
Families
for ABCC11 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ABCC11 for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry Q96J66ProtoNet protein and cluster: Q96J66 UniProtKB/Swiss-Prot: ABCCB_HUMAN, Q96J66Similarity: Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamilySimilarity: Contains 2 ABC transmembrane type-1 domainsSimilarity: Contains 2 ABC transporter domains |
Function
for ABCC11 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ABCCB_HUMAN, Q96J66Function: Participates in physiological processes involving bile acids, conjugated steroids and cyclic nucleotides.Enhances the cellular extrusion of cAMP and cGMP. Stimulates the ATP-dependent uptake of a range of physiological andsynthetic lipophilic anions, including the glutathione S-conjugates leukotriene C4 and dinitrophenyl S-glutathione,steroid sulfates such as dehydroepiandrosterone 3-sulfate (DHEAS) and estrone 3-sulfate, glucuronides such asestradiol 17-beta-D-glucuronide (E(2)17betaG), the monoanionic bile acids glycocholate and taurocholate, andmethotrexate. Probably functions to secrete earwax
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ABCC11 (see all 3)
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ABCC11 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005524 | ATP binding |
IEA | -- | | GO:0042626 | ATPase activity, coupled to transmembrane movement of substances |
IEA | -- |
ABCC11 for ontologies About GeneDecksing
|
Pathways & Interactions
for ABCC11 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | ABC-family proteins mediated transport | | | 2 | SLC-mediated transmembrane transport | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 
Reactome Pathways for ABCC11
1 
Kegg Pathway (Kegg details for ABCC11):
ABCC11 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ABCC11
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0055085 | transmembrane transport |
TAS | -- |
ABCC11 for ontologies About GeneDecksing
|
Drugs & Compounds
for ABCC11 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
ABCC11 for compounds About GeneDecksing
 Browse Tocris compounds for ABCC11
1 HMDB Compound for ABCC11 About this table
7 DrugBank Compounds for ABCC11 About this table
6 Novoseek chemical compound relationships for ABCC11 gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| adefovir |
51 |
4 |
12764137 (2), 16868766 (1) |
| 5fluorouracil |
49.9 |
16 |
17237272 (4), 18310281 (2), 12764137 (1), 17216005 (1) |
| methotrexate |
46.1 |
12 |
17237272 (2), 19248091 (1), 18310281 (1), 15537867 (1) (see all 5) |
| dehydroepiandrosterone sulfate |
40 |
5 |
16359813 (2), 15537867 (1) |
| dhea |
34.8 |
5 |
16868766 (2), 16359813 (1) |
| iron |
0 |
2 |
16410366 (1), 8336670 (1) |
Search CenterWatch for drugs/clinical trials and news about ABCC11 / ABCCB
|
Transcripts
for ABCC11 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ABCC11 gene (3 alternative transcripts): NM_032583.3 NM_033151.3 NM_145186.2 Unigene Cluster for ABCC11: ATP-binding cassette, sub-family C (CFTR/MRP), member 11 Hs.652267 [show with all ESTs]Unigene Representative Sequence: AY04021910 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000565329(uc010cbg.1) ENST00000353782(uc010vgk.1 uc002efh.1)
ENST00000356608 ENST00000394747(uc002eff.1) ENST00000569172 ENST00000567385
ENST00000565487 ENST00000569991 ENST00000394748(uc002efg.1) ENST00000537808(uc010vgl.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ABCC11 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ABCC11 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): ABCC11 (NM_033151) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ABCC11 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ABCC11 |
Additional cDNA sequence: AF352582.1 AF367202.1 AF411579.1 AK301547.1 AL117406.1 AY040219.1 9 DOTS entries: DT.86846741 DT.97824116 DT.95249093 DT.97771477 DT.120721587 DT.97824115 DT.120721493 DT.442910 DT.120721449 24/26 AceView cDNA sequences (see all 26): NM_033151 NM_032583 BF447217 BF924908 AY040219 NM_145186 AL117406 BC039085 AF411579 AF352582 AA412392 AF367202 BI462847 W94983 BE089591 BE869517 T81803 AI676121 AI401832 BF760362 AW372855 AW372856 T82135 CD634784
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for ABCC11 About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ | 22a | · | 22b | ^ | 23 | ^ |
|---|
|
| SP1: | | | - | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | - | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 24 | ^ | 25 | ^ | 26 | ^ | 27 | ^ | 28 | ^ | 29 | ^ | 30 | ^ | 31 | ^ | 32 |
|---|
|
| SP1: | | | | | | | - | | | | | | | | | | | | |
| SP2: | | | | | | | - | | | | | | - | | | | | | |
| SP3: | | | | | | | - | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for ABCC11
|
Expression
for ABCC11 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ABCC11 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTGAATAATT
About this image
See ABCC11 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ABCC11
SOURCE GeneReport for Unigene cluster: Hs.652267
UniProtKB/Swiss-Prot: ABCCB_HUMAN, Q96J66Tissue specificity: Expressed in many tissues. Not expressed in kidney, spleen and colon. Highly expressed in breastcancer. Expressed at moderate levels in normal breast and testis and at very low levels in liver, brain and placenta
SABiosciences Expression via Pathway-Focused PCR Array including ABCC11: | Drug Transporters in human mouse rat |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ABCC11
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ABCC11 |
Orthologs
for ABCC11 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for ABCC11 gene from 4/14 species (see all 14) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
ABCC126 |
-- |
47(a) |
1 → many |
LGc(2649195-2725866) |
zebrafish
(Danio rerio) |
Actinopterygii |
abcc126 |
ATP-binding cassette, sub-family C (CFTR/MRP), mem... |
47(a) |
1 → many |
7(39550710-39575433) |
worm
(Caenorhabditis elegans) |
Secernentea |
mrp-56 |
Multidrug Resistance Protein family member (mrp-5)... |
28(a) |
1 → many |
X(14938182-14946249) |
barley
(Hordeum vulgare) |
Liliopsida |
Hv.102352 |
Transcribed sequence with moderate similarity to protein more |
67.69(n) |
|
BQ469119.1 |
ENSEMBL Gene Tree for ABCC11 (if available)
TreeFam Gene Tree for ABCC11 (if available) |
Paralogs
for ABCC11 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ABCC11 gene
- ABCC42 ABCC122 ABCC12 ABCC102 CFTR2 ABCC82 ABCC52 ABCC62
- ABCC32 ABCC22 ABCC92
18/20 SIMAP similar genes for ABCC11 using alignment to 3 protein entries: ABCCB_HUMAN (see all proteins)
(see all similar genes):ABCC12 ABCB4 CFTR TAP1 MOAT-B DKFZp434I2115
ABCC5 NG-TRA ABC-transporter ABCC2 ABCC4 ABCG2
DKFZp781G125 ABCC9 ABCC1 ABCC3 ABCC8 MRP3
ABCC11 for paralogs About GeneDecksing
|
Genomic Variants
for ABCC11 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
UniProtKB/Swiss-Prot: ABCCB_HUMAN, Q96J66Polymorphism: The allele with Arg-184 is responsible for the dry earwax phenotype [MIM:117800]. Human earwax is aMendelian trait consisting of wet and dry types. The wet earwax is brownish and sticky, whereas the dry type lackscerumen. The wet cerumen phenotype is completely dominant. The dry type is seen frequently (80-95%) among East Asians,but uncommon (0-3%) in populations of European and African origins. Intermediate frequencies (30-50%) of the dry typeare seen in populations of Southern Asia, the Pacific Islands, Central Asia and Asia Minor, as well as among theNative North American and Inuit of Asian ancestry
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 16 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ABCC11 (48200821 - 48281479 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ABCC11: --
Human Gene Mutation Database (HGMD): ABCC11
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ABCC11 |
|
Disorders
/ Diseases
for ABCC11 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ABCC11 for disorders About GeneDecksing
OMIM gene information: 607040
OMIM disorders: 117800
17  diseases for ABCC11: About MalaCardsearwax, wet/dry axillary odor, variation in colostrum secretion, variation in dubin-johnson syndrome
patent ductus arteriosus dengue hemorrhagic fever hemorrhagic fever iron overload
acute myeloid leukemia myeloid leukemia rheumatoid arthritis breast cancer
pancreatic carcinoma arthritis leukemia pancreatitis
carcinoma
1 disease from the University of Copenhagen DISEASES database for ABCC11:Dubin-Johnson syndrome 1 Novoseek disease relationship for ABCC11 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| breast cancer |
19.2 |
2 |
18310281 (5), 11591886 (2), 19383836 (1), 19248091 (1) |
Human Genome Epidemiology (HuGE) Navigator: ABCC11 (6 documents)
Export disorders for ABCC11 gene to outside databases
|
Publications
for ABCC11 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ABCC11 gene, integrated from 9 sources (see all 57):
(articles sorted by number of sources associating them with ABCC11) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- MRP8, ATP-binding cassette C11 (ABCC11), is a cyclic nucleotide efflux pump and a resistance factor for fluoropyrimidines 2',3'- dideoxycytidine and 9'-(2'-phosphonylmethoxyethyl)adenine. (PubMed id 12764137)1, 2, 7, 9 Guo Y....Kruh G.D. (2003)
- Transport of bile acids, sulfated steroids, estradiol 17-beta-D- glucuronide, and leukotriene C4 by human multidrug resistance protein 8 (ABCC11). (PubMed id 15537867)1, 2, 7, 9 Chen Z.S.... Kruh G.D. (2005)
- Two new genes from the human ATP-binding cassette transporter superfamily, ABCC11 and ABCC12, tandemly duplicated on chromosome 16q12. (PubMed id 11483364)1, 2, 3, 9 Tammur J....Allikmets R. (2001)
- Multiple splicing variants of two new human ATP-binding cassette transporters, ABCC11 and ABCC12. (PubMed id 11688999)1, 2, 9 Yabuuchi H.... Ishikawa T. (2001)
- MRP8, a new member of ABC transporter superfamily, identified by EST database mining and gene prediction program, is highly expressed in breast cancer. (PubMed id 11591886)1, 2, 9 Bera T.K.... Pastan I.H. (2001)
- A SNP in the ABCC11 gene is the determinant of human earwax type. (PubMed id 16444273)1, 2, 9 Yoshiura K.... Niikawa N. (2006)
- The human ATP-binding cassette (ABC) transporter supe rfamily. (PubMed id 11435397)1, 3 Dean M....Allikmets R. (2001)
- Human multidrug resistance protein 8 (MRP8/ABCC11), an apical efflux pump for steroid sulfates, is an axonal protein of the CNS and peripheral nervous system. (PubMed id 16359813)1, 9 Bortfeld M....Keppler D. (2006)
- A functional ABCC11 allele is essential in the bioche mical formation of human axillary odor. (PubMed id 19710689)1, 9 Martin A....Natsch A. (2010)
- Expression of ABCC-type nucleotide exporters in blasts of adult acute myeloid leukemia: relation to long-term survival. (PubMed id 19240178)1, 9 Guo Y....Schaich M. (2009)
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External Searches for ABCC11 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing ABCC11 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing ABCC11 gene
(According to HUGE)
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Specialized Databases showing ABCC11 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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|
| Name | Description |
| PharmGKB entry for ABCC11 | Pharmacogenomics, SNPs, Pathways | | ATLAS Chromosomes in Cancer entry for ABCC11 | Genetics and Cytogenetics in Oncology and Haematology | | Protein Spotlight | http://web.expasy.org/spotlight/back_issues/sptlt067.shtml | | ABCMdb | http://abcmutations.hegelab.org/proteinDetails?uniprot_id=Q96J66 |
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| Patent Information for ABCC11 gene:
Search GeneIP for patents involving ABCC11
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for ABCC11 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | OriGene Antibodies for ABCC11 | | OriGene shRNA RFP for ABCC11 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ABCC11 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ABCC11 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ABCC11 | | OriGene 3'-UTR Clone for ABCC11 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ABCC11 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ABCC11 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for ABCC11 | | OriGene Custom Protein Services for ABCC11 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ABCC11 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ABCC11 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ABCC11 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ABCC11 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ABCC11 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ABCC11 |
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| | | | Search Tocris compounds for ABCC11 |
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 | | | ABCC11 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ABCC11 |
|  |  |  | | | | ThermoFisher Antibodies for ABCC11 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ABCC11 |
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