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Aliases for ABCC11 Gene

Aliases for ABCC11 Gene

  • ATP Binding Cassette Subfamily C Member 11 2 3 5
  • ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 11 2 3
  • Multidrug Resistance-Associated Protein 8 3 4
  • MRP8 3 4
  • ATP-Binding Cassette Transporter Sub-Family C Member 11 3
  • ATP-Binding Cassette Transporter MRP8 3
  • ATP-Binding Cassette Protein C11 3
  • Multi-Resistance Protein 8 3
  • EWWD 3
  • WW 3

External Ids for ABCC11 Gene

Previous GeneCards Identifiers for ABCC11 Gene

  • GC16M038615
  • GC16M047938
  • GC16M047978
  • GC16M046758
  • GC16M034090

Summaries for ABCC11 Gene

Entrez Gene Summary for ABCC11 Gene

  • The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This ABC full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. The product of this gene participates in physiological processes involving bile acids, conjugated steroids, and cyclic nucleotides. In addition, a SNP in this gene is responsible for determination of human earwax type. This gene and family member ABCC12 are determined to be derived by duplication and are both localized to chromosome 16q12.1. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for ABCC11 Gene

ABCC11 (ATP Binding Cassette Subfamily C Member 11) is a Protein Coding gene. Diseases associated with ABCC11 include breast cancer. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and ABC-family proteins mediated transport. GO annotations related to this gene include ATPase activity and organic anion transmembrane transporter activity. An important paralog of this gene is ABCC12.

UniProtKB/Swiss-Prot for ABCC11 Gene

  • Participates in physiological processes involving bile acids, conjugated steroids and cyclic nucleotides. Enhances the cellular extrusion of cAMP and cGMP. Stimulates the ATP-dependent uptake of a range of physiological and synthetic lipophilic anions, including the glutathione S-conjugates leukotriene C4 and dinitrophenyl S-glutathione, steroid sulfates such as dehydroepiandrosterone 3-sulfate (DHEAS) and estrone 3-sulfate, glucuronides such as estradiol 17-beta-D-glucuronide (E(2)17betaG), the monoanionic bile acids glycocholate and taurocholate, and methotrexate. Probably functions to secrete earwax.

Gene Wiki entry for ABCC11 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ABCC11 Gene

Genomics for ABCC11 Gene

Regulatory Elements for ABCC11 Gene

Transcription factor binding sites by QIAGEN in the ABCC11 gene promoter:

Genomic Location for ABCC11 Gene

Chromosome:
16
Start:
48,166,910 bp from pter
End:
48,247,568 bp from pter
Size:
80,659 bases
Orientation:
Minus strand

Genomic View for ABCC11 Gene

Genes around ABCC11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ABCC11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ABCC11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ABCC11 Gene

Proteins for ABCC11 Gene

  • Protein details for ABCC11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96J66-ABCCB_HUMAN
    Recommended name:
    ATP-binding cassette sub-family C member 11
    Protein Accession:
    Q96J66
    Secondary Accessions:
    • Q8TDJ0
    • Q96JA6
    • Q9BX80

    Protein attributes for ABCC11 Gene

    Size:
    1382 amino acids
    Molecular mass:
    154301 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ABCC11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ABCC11 Gene

Proteomics data for ABCC11 Gene at MOPED

Post-translational modifications for ABCC11 Gene

  • Glycosylation at Asn 838, Asn 844, and Asn 992
  • Modification sites at PhosphoSitePlus

Other Protein References for ABCC11 Gene

Antibody Products

No data available for DME Specific Peptides for ABCC11 Gene

Domains & Families for ABCC11 Gene

Gene Families for ABCC11 Gene

Protein Domains for ABCC11 Gene

Suggested Antigen Peptide Sequences for ABCC11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96J66

UniProtKB/Swiss-Prot:

ABCCB_HUMAN :
  • Contains 2 ABC transmembrane type-1 domains.
  • Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
Domain:
  • Contains 2 ABC transmembrane type-1 domains.
  • Contains 2 ABC transporter domains.
Family:
  • Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
genes like me logo Genes that share domains with ABCC11: view

Function for ABCC11 Gene

Molecular function for ABCC11 Gene

UniProtKB/Swiss-Prot Function:
Participates in physiological processes involving bile acids, conjugated steroids and cyclic nucleotides. Enhances the cellular extrusion of cAMP and cGMP. Stimulates the ATP-dependent uptake of a range of physiological and synthetic lipophilic anions, including the glutathione S-conjugates leukotriene C4 and dinitrophenyl S-glutathione, steroid sulfates such as dehydroepiandrosterone 3-sulfate (DHEAS) and estrone 3-sulfate, glucuronides such as estradiol 17-beta-D-glucuronide (E(2)17betaG), the monoanionic bile acids glycocholate and taurocholate, and methotrexate. Probably functions to secrete earwax.

Gene Ontology (GO) - Molecular Function for ABCC11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
GO:0042626 ATPase activity, coupled to transmembrane movement of substances IEA --
genes like me logo Genes that share ontologies with ABCC11: view
genes like me logo Genes that share phenotypes with ABCC11: view

Human Phenotype Ontology for ABCC11 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

CRISPR Products

miRNA for ABCC11 Gene

miRTarBase miRNAs that target ABCC11

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for ABCC11 Gene

Localization for ABCC11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ABCC11 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ABCC11 Gene COMPARTMENTS Subcellular localization image for ABCC11 gene
Compartment Confidence
extracellular 5
plasma membrane 5

Gene Ontology (GO) - Cellular Components for ABCC11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane IDA 16359813
genes like me logo Genes that share ontologies with ABCC11: view

Pathways & Interactions for ABCC11 Gene

genes like me logo Genes that share pathways with ABCC11: view

Pathways by source for ABCC11 Gene

1 KEGG pathway for ABCC11 Gene

Interacting Proteins for ABCC11 Gene

Gene Ontology (GO) - Biological Process for ABCC11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0055085 transmembrane transport IEA,TAS --
genes like me logo Genes that share ontologies with ABCC11: view

No data available for SIGNOR curated interactions for ABCC11 Gene

Drugs & Compounds for ABCC11 Gene

(12) Drugs for ABCC11 Gene - From: DrugBank, HMDB, Novoseek, FDA Approved Drugs, and PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Methotrexate Approved Pharma Transporter, substrate Folate antagonist,inhibits DFHR, Cytotoxic agent 1444
Probenecid Approved Pharma Inhibition, Inhibitor, Transporter, inhibitor 27
Folic Acid Approved Nutra Transporter, substrate 2924
Conjugated Estrogens Approved Pharma Transporter, substrate 0
Indomethacin Approved, Investigational Pharma Partial agonist, Agonist, Transporter, inhibitor Cox inhibitor 106

(2) Additional Compounds for ABCC11 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ABCC11: view

Transcripts for ABCC11 Gene

Unigene Clusters for ABCC11 Gene

ATP-binding cassette, sub-family C (CFTR/MRP), member 11:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ABCC11 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22a · 22b ^ 23 ^
SP1: - -
SP2: - -
SP3: -
SP4:
SP5:

ExUns: 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32
SP1: -
SP2: - -
SP3: -
SP4:
SP5:

Relevant External Links for ABCC11 Gene

GeneLoc Exon Structure for
ABCC11
ECgene alternative splicing isoforms for
ABCC11

Expression for ABCC11 Gene

mRNA expression in normal human tissues for ABCC11 Gene

mRNA differential expression in normal tissues according to GTEx for ABCC11 Gene

This gene is overexpressed in Liver (x11.0), Testis (x8.2), and Breast - Mammary Tissue (x7.6).

Protein differential expression in normal tissues from HIPED for ABCC11 Gene

This gene is overexpressed in Heart (29.7), Monocytes (27.6), and Liver (11.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ABCC11 Gene



SOURCE GeneReport for Unigene cluster for ABCC11 Gene Hs.652267

mRNA Expression by UniProt/SwissProt for ABCC11 Gene

Q96J66-ABCCB_HUMAN
Tissue specificity: Expressed in many tissues. Not expressed in kidney, spleen and colon. Highly expressed in breast cancer. Expressed at moderate levels in normal breast and testis and at very low levels in liver, brain and placenta.
genes like me logo Genes that share expression patterns with ABCC11: view

Protein tissue co-expression partners for ABCC11 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for ABCC11 Gene

Orthologs for ABCC11 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ABCC11 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia ABCC11 35
  • 81.44 (n)
  • 75.49 (a)
ABCC11 36
  • 75 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ABCC11 35
  • 99.06 (n)
  • 98.77 (a)
ABCC11 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ABCC11 36
  • 67 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ABCC11 36
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ABCC11 36
  • 56 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii abcc12 36
  • 47 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Sur 37
  • 41 (a)
Sur 36
  • 16 (a)
OneToMany
barley
(Hordeum vulgare)
Liliopsida Hv.10235 35
wheat
(Triticum aestivum)
Liliopsida Ta.27443 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 36 (a)
OneToMany
Species with no ortholog for ABCC11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • worm (Caenorhabditis elegans)

Evolution for ABCC11 Gene

ENSEMBL:
Gene Tree for ABCC11 (if available)
TreeFam:
Gene Tree for ABCC11 (if available)

Paralogs for ABCC11 Gene

Paralogs for ABCC11 Gene

genes like me logo Genes that share paralogs with ABCC11: view

Variants for ABCC11 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for ABCC11 Gene

Q96J66-ABCCB_HUMAN
The allele with Arg-180 is responsible for the dry earwax phenotype [MIM:117800]. Human earwax is a Mendelian trait consisting of wet and dry types. The wet earwax is brownish and sticky, whereas the dry type lacks cerumen. The wet cerumen phenotype is completely dominant. The dry type is seen frequently (80-95%) among East Asians, but uncommon (0-3%) in populations of European and African origins. Intermediate frequencies (30-50%) of the dry type are seen in populations of Southern Asia, the Pacific Islands, Central Asia and Asia Minor, as well as among the Native North American and Inuit of Asian ancestry.

Sequence variations from dbSNP and Humsavar for ABCC11 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs16945988 - 48,231,866(+) TGCCA(C/T)GATTC upstream-variant-2KB, reference, missense
rs17822931 - 48,224,287(+) TGGCC(C/T)GAGTA upstream-variant-2KB, reference, missense
rs11863236 - 48,216,115(+) TTACC(G/T)CCAGT reference, missense, utr-variant-5-prime
rs17822471 - 48,208,468(+) TCCCC(A/G)TGTTG reference, missense
rs16945930 - 48,200,416(+) ATAGA(C/T)GGCGC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for ABCC11 Gene

Variant ID Type Subtype PubMed ID
nsv827641 CNV Gain 20364138

Variation tolerance for ABCC11 Gene

Residual Variation Intolerance Score: 97.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 18.43; 98.56% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ABCC11 Gene

HapMap Linkage Disequilibrium report
ABCC11
Human Gene Mutation Database (HGMD)
ABCC11

Disorders for ABCC11 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ABCC11 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
breast cancer
  • breast cancer, invasive ductal
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ABCC11

Genetic Association Database (GAD)
ABCC11
Human Genome Epidemiology (HuGE) Navigator
ABCC11
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ABCC11
genes like me logo Genes that share disorders with ABCC11: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ABCC11 Gene

Publications for ABCC11 Gene

  1. Two new genes from the human ATP-binding cassette transporter superfamily, ABCC11 and ABCC12, tandemly duplicated on chromosome 16q12. (PMID: 11483364) Tammur J. … Allikmets R. (Gene 2001) 2 3 4 23 67
  2. Transport of bile acids, sulfated steroids, estradiol 17-beta-D- glucuronide, and leukotriene C4 by human multidrug resistance protein 8 (ABCC11). (PMID: 15537867) Chen Z.S. … Kruh G.D. (Mol. Pharmacol. 2005) 3 23 25 26
  3. MRP8, ATP-binding cassette C11 (ABCC11), is a cyclic nucleotide efflux pump and a resistance factor for fluoropyrimidines 2',3'- dideoxycytidine and 9'-(2'-phosphonylmethoxyethyl)adenine. (PMID: 12764137) Guo Y. … Kruh G.D. (J. Biol. Chem. 2003) 3 23 25 26
  4. A functional ABCC11 allele is essential in the biochemical formation of human axillary odor. (PMID: 19710689) Martin A. … Natsch A. (J. Invest. Dermatol. 2010) 3 23
  5. Expression of ABCC-type nucleotide exporters in blasts of adult acute myeloid leukemia: relation to long-term survival. (PMID: 19240178) Guo Y. … Schaich M. (Clin. Cancer Res. 2009) 3 23

Products for ABCC11 Gene

Sources for ABCC11 Gene

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