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ABCC11 Gene

protein-coding GIFtS: 57

GC16M046758

ATP-binding cassette, sub-family C (CFTR/MRP), member 11
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
EWWD ^², ⁵
MRP8 ^¹, ², ³, ⁵
OTTHUMP00000164191 ^²
WW ^², ⁵

Descriptions
ATP-binding cassette protein C11 ^²
ATP-binding cassette transporter MRP8 ^²
ATP-binding cassette, sub-family C (CFTR/MRP), member 11 ^²
ATP-binding cassette, sub-family C, member 11 ^²
Multidrug resistance-associated protein 8 ^³
multi-resistance protein 8 ^²

External Ids
HGNC: 14639¹
Entrez Gene: 85320²
UniProtKB: Q96J66³
Ensembl: ENSG00000121270⁷

Search outside databases for aliases for ABCC11 gene

Previous GC identifers: GC16M038615 GC16M048249 GC16M047938 GC16M047978

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for ABCC11:

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC)

transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes.

ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20,

White). This ABC full transporter is a member of the MRP subfamily which is involved in multi-drug

resistance. The product of this gene participates in physiological processes involving bile acids,

conjugated steroids, and cyclic nucleotides. In addition, a SNP in this gene is responsible for

determination of human earwax type. This gene and family member ABCC12 are determined to be

derived by duplication and are both localized to chromosome 16q12.1. Multiple alternatively

spliced transcript variants have been described for this gene. [provided by RefSeq]

UniProtKB/Swiss-Prot: ABCCB_HUMAN, Q96J66

Function: Participates in physiological processes involving bile acids, conjugated steroids and

cyclic nucleotides. Enhances the cellular extrusion of cAMP and cGMP. Stimulates the ATP-dependent

uptake of a range of physiological and synthetic lipophilic anions, including the glutathione

S-conjugates leukotriene C4 and dinitrophenyl S-glutathione, steroid sulfates such as

dehydroepiandrosterone 3-sulfate (DHEAS) and estrone 3-sulfate, glucuronides such as estradiol

17-beta-D-glucuronide (E(2)17betaG), the monoanionic bile acids glycocholate and taurocholate, and

methotrexate. Probably functions to secrete earwax

Gene Wiki entry for ABCC11

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ABCC11 gene

Entrez Gene cytogenetic band: 16q12.1 Ensembl cytogenetic band: 16q12.1 HGNC cytogenetic band: 16q12

ABCC11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 16 GeneLoc Exon Structure

GeneLoc location for GC16M046758: (about GC identifiers)

Start:	46,758,322 bp from pter
End:	46,838,806 bp from pter
Size:	80,485 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000016.8 NT_010498.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: ABCCB_HUMAN, Q96J66 (See protein sequence)

Recommended Name: ATP-binding cassette transporter sub-family C member 11

Size: 1382 amino acids; 154301 Da

Subcellular location: Membrane; Multi-pass membrane protein

Secondary accessions: Q8TDJ0 Q96JA6 Q9BX80

Alternative splicing: 2 isoforms: Q96J66-1 Q96J66-2

REFSEQ proteins (3 alternative transcripts):

NP_115972.2 NP_149163.2 NP_660187.1

ENSEMBL proteins:

ENSP00000311326 ENSP00000378230 ENSP00000349017 ENSP00000378231

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (ABCC11)
	Human Recombinant Proteins from Abnova (ABCC11)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016020	membrane	IEA	--
GO:0016021	integral to membrane	IEA	--

About this table

Antibodies for ABCC11:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (ABCC11), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (ABCC11)
	Novus Biologicals Antibodies for ABCC11

Assays for ABCC11:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q96J66

ProtoNet protein and cluster: Q96J66

UniProtKB/Swiss-Prot: ABCCB_HUMAN, Q96J66

Similarity: Belongs to the ABC transporter family. Conjugate transporter (TC 3.A.1.208) subfamily

Similarity: Contains 2 ABC transmembrane type-1 domains

Similarity: Contains 2 ABC transporter domains

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ABCC11)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ABCC11)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_033151

Applied Biosystems Silencer® siRNAs for ABCC11

Sigma-Aldrich siRNA and siRNA Panels for ABCC11

Sigma-Aldrich shRNA for ABCC11

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for ABCC11
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_032583
Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_032583
untagged cDNA clones in CMV expression vector (see all 3): NM_032583

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_032583

UniProtKB/Swiss-Prot: ABCCB_HUMAN, Q96J66

Function: Participates in physiological processes involving bile acids, conjugated steroids and

cyclic nucleotides. Enhances the cellular extrusion of cAMP and cGMP. Stimulates the ATP-dependent

uptake of a range of physiological and synthetic lipophilic anions, including the glutathione

S-conjugates leukotriene C4 and dinitrophenyl S-glutathione, steroid sulfates such as

dehydroepiandrosterone 3-sulfate (DHEAS) and estrone 3-sulfate, glucuronides such as estradiol

17-beta-D-glucuronide (E(2)17betaG), the monoanionic bile acids glycocholate and taurocholate, and

methotrexate. Probably functions to secrete earwax

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0005524	ATP binding	IEA	--
GO:0016887	ATPase activity	IEA	--
GO:0042626	ATPase activity, coupled to transmembrane movement of substances	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

5/54 Interacting proteins for ABCC11 (ENSP00000349017³) via UniProtKB, MINT, and/or STRING (see all 54 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
NEDD4	ENSP00000345530³	STRING (score=.994)
YAP1	ENSP00000282441³	STRING (score=.967)
NEDD4L	ENSP00000256832³	STRING (score=.966)
SCNN1G	ENSP00000300061³	STRING (score=.946)
WWP1	ENSP00000265428³	STRING (score=.946)

About this table

1 Gene Ontology (GO) biological process term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006810	transport	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for ABCC11
3 Novoseek chemical compound relationships for ABCC11 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
dehydroepiandrosterone sulfate	43.86	5	16359813 (2), 15537867 (1)
dhea	38.89	5	16868766 (2), 16359813 (1)
iron	0.00	2	16410366 (1), 8336670 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ABCC11)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ABCC11)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_033151

Sigma-Aldrich siRNA and siRNA Panels for ABCC11

Sigma-Aldrich shRNA for ABCC11

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_032583 NM_033151 NM_145186

REFSEQ mRNAs for ABCC11 gene (3 alternative transcripts):

NM_032583.3 NM_033151.3 NM_145186.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_032583 NM_033151 NM_145186

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_032583
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_032583
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_032583

Additional cDNA sequence:

AF352582.1 AF367202.1 AF411579.1 AK301547.1 AL117406.1 AY040219.1

10 DOTS entries:

DT.86846741 DT.97824116 DT.95249093 DT.97771477 DT.120721587 DT.97824115 DT.120721493 DT.120721449

DT.207099 DT.442910

24/26 AceView cDNA sequences (see all 26 ):

NM_145186 AY040219 NM_032583 AL117406 BF924908 NM_033151 BF447217 BC039085

AF367202 AF352582 AA412392 AF411579 BE089591 BI462847 T81803 W94983

BE869517 AI401832 AI676121 BF760362 AW372856 AW372855 T82135 CD634784

highest scoring ESTs for ABCC11:

AF352582 AF367202 AF411579 BE089591 CD634784 CD634785 NM_032583 NM_033151 NM_145186 AI401832

Unigene Cluster for ABCC11:

ATP-binding cassette, sub-family C (CFTR/MRP), member 11

Hs.652267 [show with all ESTs]

Unigene Representative Sequence: AY040219

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for ABCC11

ExUns:	1	^	2a	·	2b	^	3	^	4	^	5	^	6	^	7	^	8	^	9a	·	9b	^	10	^	11	^	12	^	13	^	14	^	15	^	16	^	17	^	18	^	19	^	20	^	21	^	22a	·	22b	^	23	^
SP1:			-										-
SP2:			-										-
SP3:													-
SP4:
SP5:

ExUns:	24	^	25	^	26	^	27	^	28	^	29	^	30	^	31	^	32
SP1:							-
SP2:							-						-
SP3:							-
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for ABCC11

4 Ensembl transcripts including schematic representations:

ENST00000353782 ENST00000394747 ENST00000356608 ENST00000394748

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

ABCC11 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ABCC11

¹ / ² / ³

4 probe-sets matching ABCC11 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
68784_at²^{, 3}	U95-D	2	0.81	0.77	1.00	1.00	AI401832	0.80	0.80	0.80	1
224146_s_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AF352582	0.80	0.88	0.84	1
224146_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1554911_at*²	U133Plus2	NULL	0.00	0.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CTGAATAATT

SOURCE GeneReport for Unigene cluster: Hs.652267
UniProtKB/Swiss-Prot: ABCCB_HUMAN, Q96J66
Tissue specificity: Expressed in many tissues. Not expressed in kidney, spleen and colon. Highly
expressed in breast cancer. Expressed at moderate levels in normal breast and testis and at very
low levels in liver, brain and placenta

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ABCC11 gene from 5/6 species (see all 6 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ABCC11¹	--	ATP-binding cassette, sub-family C (CFTR/MRP), member more	81.44(n) 75.49(a)	478138 XM_535314.2 XP_535314.2
chimpanzee (Pan troglodytes)	ABCC11¹	--	ATP-binding cassette, sub-family C (CFTR/MRP), member more	99.06(n) 98.77(a)	473275 XM_001163586.1 XP_001163586.1
cow (Bos taurus)	ABCC11¹	--	ATP-binding cassette, sub-family C (CFTR/MRP), member more	79.95(n) 74.08(a)	522437 XM_600718.3 XP_600718.3
fruit fly (Drosophila melanogaster)	Sur³	31B1	heart development sulfonylurea receptor	41(a)	--
barley (Hordeum vulgare)	Hv.10235²	--	Transcribed sequence with moderate similarity to protein more	67.69(n)	BQ469119.1

About this table Species with no ortholog for ABCC11

ENSEMBL Gene Tree for ABCC11

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for ABCC11 gene

ABCC12²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

UniProtKB/Swiss-Prot: ABCCB_HUMAN, Q96J66

Polymorphism: The allele with Arg-184 is responsible for the dry earwax phenotype [MIM:117800].

Human earwax is a mendelian trait consisting of wet and dry types. The wet earwax is brownish and

sticky, whereas the dry type lacks cerumen. The wet cerumen phenotype is completely dominant. The

dry type is seen frequently (80-95%) among East Asians, but uncommon (0-3%) in populations of

European and African origins. Intermediate frequencies (30-50%) of the dry type are seen in

populations of Southern Asia, the Pacific Islands, Central Asia and Asia Minor, as well as among

the Native North American and Inuit of Asian ancestry

10/292 NCBI SNPs in ABCC11 are shown (see all 292 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 128)

AB	SNP ID	Valid	Chr 16 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs11859911^1,2	A,C,F,H	46824040(+)	`ATTCAT/CGTGCC`	3	--	int¹ ng3¹		7	EU EA WA NA	560
--	rs11863236^1,2	A,C,F,H	46807527(+)	`TTACCG/TCCAGT`	3	A/E	mis¹		8	EU EA WA	832
	rs13332304^1,2	A,C,F,H	46825003(+)	`TTAAAT/GTAAAA`	3	--	ng3¹ int¹		7	EU EA WA NA	560
	rs11865596^1,2	A,C,F,H	46824332(+)	`TGAggC/Ttgggt`	3	--	int¹ ng3¹		4	EU EA WA	412
	rs10521167^1,2	C,F,H	46827062(-)	`GGGAAT/CGCTTC`	2	--	ng3¹		12	NS EU EA WA NA	652
	rs13331031^1,2	C,F,H	46825079(+)	`CACACA/GCAAAG`	3	--	int¹ ng3¹		7	EU EA WA NA	562
	rs16945988^1,2	C,F,H	46823278(+)	`TGCCAC/TGATTC`	3	R/H	mis¹ ese³		11	NA EU EA WA	968
	rs16945990^1,2	C,F,H	46823690(+)	`TTTAAC/TTGTGT`	3	--	int¹ ng3¹		7	NA EU EA WA	562
	rs16945930^1,2	C,F,H	46791828(+)	`ATAGAC/TGGCGC`	3	V/I	mis¹		12	NA EU EA WA	1056
	rs17822471^1,2	C,F,H	46799880(+)	`TCCCCG/ATGTTG`	3	M/T	mis¹ ese³		11	NA EU EA WA	982

About this table

HapMap Linkage Disequilibrium images for ABCC11 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 607040 disorders: 117800

1 Novoseek disease relationship for ABCC11 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
breast cancer	0.00	1	18310281 (5), 11591886 (2), 19248091 (1)

About this table

Human Gene Mutation Database: ABCC11
Human Genome Epidemiology Navigator: ABCC11 (1 document)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/38 PubMed articles for ABCC11 gene (see all 38 ):

Two new genes from the human ATP-binding cassette transporter superfamily, ABCC11 and ABCC12, tandemly duplicated on chromosome 16q12. (PubMed id 11483364)^{1, 2, 3, 4} Tammur J....Allikmets R. (2001)
MRP8, ATP-binding cassette C11 (ABCC11), is a cyclic nucleotide efflux pump and a resistance factor for fluoropyrimidines 2',3'- dideoxycytidine and 9'-(2'-phosphonylmethoxyethyl)adenine. (PubMed id 12764137)^{1, 3, 4} Guo Y....Kruh G.D. (2003)
Multiple splicing variants of two new human ATP-binding cassette transporters, ABCC11 and ABCC12. (PubMed id 11688999)^{1, 3, 4} Yabuuchi H.... Ishikawa T. (2001)
MRP8, a new member of ABC transporter superfamily, identified by EST database mining and gene prediction program, is highly expressed in breast cancer. (PubMed id 11591886)^{1, 3, 4} Bera T.K.... Pastan I.H. (2001)
Transport of bile acids, sulfated steroids, estradiol 17-beta-D- glucuronide, and leukotriene C4 by human multidrug resistance protein 8 (ABCC11). (PubMed id 15537867)^{1, 3, 4} Chen Z.S.... Kruh G.D. (2005)
A SNP in the ABCC11 gene is the determinant of human earwax type. (PubMed id 16444273)^{1, 3, 4} Yoshiura K.... Niikawa N. (2006)
The human ATP-binding cassette (ABC) transporter superfamily. (PubMed id 11435397)^{2, 3} Dean M....Allikmets R. (2001)
Human multidrug resistance protein 8 (MRP8/ABCC11), an apical efflux pump for steroid sulfates, is an axonal protein of the CNS and peripheral nervous system. (PubMed id 16359813)^{1, 3} Bortfeld M....Keppler D. (2006)
Expression of ABCC-type nucleotide exporters in blasts of adult acute myeloid leukemia: relation to long-term survival. (PubMed id 19240178)^{1, 3} Guo Y....Schaich M. (2009)
Determination of genetic predisposition to patent ductus arteriosus in preterm infants. (PubMed id 19336370)³ Dagle J.M....Murray J.C. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 85320	HGNC: 14639	AceView: ABCC11	Ensembl:ENSG00000121270	euGenes: HUgn85320
ECgene: ABCC11	H-InvDB: ABCC11

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for ABCC11	Genetics and Cytogenetics in Oncology and Haematology
Protein Spotlight	http://www.expasy.org/spotlight/back_issues/sptlt067.shtml

Licensable Technologies for ABCC11
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for ABCC11:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ABCC11-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ABCC11		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for ABCC11		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

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	Cell Culture Products		ELISAs
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	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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ABCC11 Gene at Home site.
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ABCC11 Gene

protein-coding GIFtS: 57

Aliases &
Descriptions
for ABCC11

Summaries
for ABCC11

Genomic Location
for ABCC11

Proteins
for ABCC11

Protein Domains/
Families
for ABCC11

Gene Function
for ABCC11

Pathways & Interactions
for ABCC11

Drugs & Compounds
for ABCC11

Transcripts
for ABCC11

Expression
for ABCC11

Orthologs
for ABCC11

Paralogs
for ABCC11

SNPs/Variants
for ABCC11

Disorders & Mutations
for ABCC11

Medical News
for ABCC11

Publications
for ABCC11

Search for ABCC11

Genome Databases showing ABCC11

Other Databases showing ABCC11

Specialized Databases showing ABCC11

Licensable Technologies
for ABCC11

Services
for ABCC11

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ABCC11 Gene

protein-coding GIFtS: 57

Aliases & Descriptionsfor ABCC11

Summariesfor ABCC11

Genomic Locationfor ABCC11

Proteinsfor ABCC11

Protein Domains/Familiesfor ABCC11

Gene Functionfor ABCC11

Pathways & Interactionsfor ABCC11

Drugs & Compoundsfor ABCC11

Transcriptsfor ABCC11

Expression for ABCC11

Orthologsfor ABCC11

Paralogsfor ABCC11

SNPs/Variantsfor ABCC11

Disorders & Mutationsfor ABCC11

Medical Newsfor ABCC11

Publicationsfor ABCC11

Search for ABCC11

Genome Databases showing ABCC11

Other Databases showing ABCC11

Specialized Databases showing ABCC11

Licensable Technologiesfor ABCC11

Servicesfor ABCC11

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ABCC11

Summaries
for ABCC11

Genomic Location
for ABCC11

Proteins
for ABCC11

Protein Domains/
Families
for ABCC11

Gene Function
for ABCC11

Pathways & Interactions
for ABCC11

Drugs & Compounds
for ABCC11

Transcripts
for ABCC11

Expression
for ABCC11

Orthologs
for ABCC11

Paralogs
for ABCC11

SNPs/Variants
for ABCC11

Disorders & Mutations
for ABCC11

Medical News
for ABCC11

Publications
for ABCC11

Licensable Technologies
for ABCC11

Services
for ABCC11