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Aliases for ABCC10 Gene

Aliases for ABCC10 Gene

  • ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 10 2 3
  • MRP7 3 4 6
  • ATP-Binding Cassette Sub-Family C Member 10 3 4
  • SIMRP7 3 4
  • Multidrug Resistance-Associated Protein 7 3
  • EST182763 3

External Ids for ABCC10 Gene

Summaries for ABCC10 Gene

Entrez Gene Summary for ABCC10 Gene

  • The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This ABC full-transporter is a member of the MRP subfamily which is involved in multi-drug resistance. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Nov 2010]

GeneCards Summary for ABCC10 Gene

ABCC10 (ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 10) is a Protein Coding gene. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Tenofovir/Adefovir Pathway, Pharmacokinetics. GO annotations related to this gene include ATPase activity, coupled to transmembrane movement of substances.

UniProtKB/Swiss-Prot for ABCC10 Gene

  • ATP-dependent transporter probably involved in cellular detoxification through lipophilic anion extrusion.

Gene Wiki entry for ABCC10 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ABCC10 Gene

Genomics for ABCC10 Gene

Genomic Location for ABCC10 Gene

Start:
43,427,366 bp from pter
End:
43,450,430 bp from pter
Size:
23,065 bases
Orientation:
Plus strand

Genomic View for ABCC10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ABCC10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ABCC10 Gene

Regulatory Elements for ABCC10 Gene

Proteins for ABCC10 Gene

  • Protein details for ABCC10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T3U5-MRP7_HUMAN
    Recommended name:
    Multidrug resistance-associated protein 7
    Protein Accession:
    Q5T3U5
    Secondary Accessions:
    • Q8NHX7
    • Q9H7N2
    • Q9NXY3
    • Q9UF48

    Protein attributes for ABCC10 Gene

    Size:
    1492 amino acids
    Molecular mass:
    161629 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA92227.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB15736.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};

    Alternative splice isoforms for ABCC10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ABCC10 Gene

Proteomics data for ABCC10 Gene at MOPED

Post-translational modifications for ABCC10 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys460, Lys664, and Lys688

Other Protein References for ABCC10 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for ABCC10 Gene

Domains for ABCC10 Gene

Gene Families for ABCC10 Gene

HGNC:
  • ABCC :ATP binding cassette transporters / subfamily C
IUPHAR :

Protein Domains for ABCC10 Gene

UniProtKB/Swiss-Prot:

MRP7_HUMAN
Domain:
  • Contains 2 ABC transmembrane type-1 domains.:
    • Q5T3U5
  • Contains 2 ABC transporter domains.:
    • Q5T3U5
Family:
  • Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.:
    • Q5T3U5
genes like me logo Genes that share domains with ABCC10: view

Function for ABCC10 Gene

Molecular function for ABCC10 Gene

GENATLAS Biochemistry: ATP binding cassettte superfamily,subfamily C (CFTR/MRP),member 10
UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=57.8 uM for 17-beta-estradiol 17-(beta-D-glucuronide) (at 37 degrees Celsius) {ECO:0000269 PubMed:12527806}; Vmax=20 pmol/min/mg enzyme toward 17-beta-estradiol 17-(beta-D- glucuronide) (at 37 degrees Celsius) {ECO:0000269 PubMed:12527806};
UniProtKB/Swiss-Prot Function: ATP-dependent transporter probably involved in cellular detoxification through lipophilic anion extrusion.

Gene Ontology (GO) - Molecular Function for ABCC10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
GO:0016887 ATPase activity --
GO:0042626 ATPase activity, coupled to transmembrane movement of substances IEA --
genes like me logo Genes that share ontologies with ABCC10: view
genes like me logo Genes that share phenotypes with ABCC10: view

Animal Models for ABCC10 Gene

MGI Knock Outs for ABCC10:

miRNA for ABCC10 Gene

miRTarBase miRNAs that target ABCC10

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for ABCC10 Gene

Localization for ABCC10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ABCC10 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ABCC10 Gene COMPARTMENTS Subcellular localization image for ABCC10 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for ABCC10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005765 lysosomal membrane IDA 17897319
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ABCC10: view

Pathways for ABCC10 Gene

genes like me logo Genes that share pathways with ABCC10: view

Pathways by source for ABCC10 Gene

Interacting Proteins for ABCC10 Gene

Gene Ontology (GO) - Biological Process for ABCC10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006200 obsolete ATP catabolic process --
GO:0006810 transport --
GO:0008152 metabolic process IEA --
GO:0055085 transmembrane transport TAS --
genes like me logo Genes that share ontologies with ABCC10: view

Compounds for ABCC10 Gene

(15) Drugbank Compounds for ABCC10 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Cyclosporine
  • Ciclosporin
59865-13-3 transporter inhibitor
Cytarabine
  • Ara-C
147-94-4 transporter substrate
Daunorubicin
20830-81-3 transporter substrate
Docetaxel
  • Docetaxel anhydrous
114977-28-5 transporter substrate
Doxorubicin
  • Adria
23214-92-8 transporter inhibitor

(4) Novoseek inferred chemical compound relationships for ABCC10 Gene

Compound -log(P) Hits PubMed IDs
estradiol-17beta-glucuronide 85 1
vincristine 63.9 6
docetaxel 63.1 7
paclitaxel 51.9 11

(1) PharmGKB related drug/compound annotations for ABCC10 Gene

Drug/compound Annotation
tenofovir CA
genes like me logo Genes that share compounds with ABCC10: view

Transcripts for ABCC10 Gene

Unigene Clusters for ABCC10 Gene

ATP-binding cassette, sub-family C (CFTR/MRP), member 10:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ABCC10 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14a · 14b · 14c ^ 15 ^ 16 ^ 17a · 17b ^ 18a ·
SP1: - -
SP2: -
SP3:
SP4:
SP5: -
SP6: -
SP7:
SP8:
SP9: -
SP10:
SP11: - - - -
SP12:

ExUns: 18b · 18c ^ 19a · 19b · 19c ^ 20 ^ 21 ^ 22 ^ 23
SP1:
SP2:
SP3: -
SP4:
SP5:
SP6:
SP7: -
SP8: -
SP9:
SP10:
SP11:
SP12:

Relevant External Links for ABCC10 Gene

GeneLoc Exon Structure for
ABCC10
ECgene alternative splicing isoforms for
ABCC10

Expression for ABCC10 Gene

mRNA expression in normal human tissues for ABCC10 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ABCC10 Gene

SOURCE GeneReport for Unigene cluster for ABCC10 Gene Hs.55879

mRNA Expression by UniProt/SwissProt for ABCC10 Gene

Q5T3U5-MRP7_HUMAN
Tissue specificity: Isoform 1 is specifically expressed in spleen. Isoform 2 is more widely expressed.
genes like me logo Genes that share expressions with ABCC10: view

Orthologs for ABCC10 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ABCC10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ABCC10 36
  • 99.55 (n)
  • 99.33 (a)
ABCC10 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ABCC10 36
  • 88.8 (n)
  • 89.78 (a)
ABCC10 37
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ABCC10 36
  • 88.53 (n)
  • 89.6 (a)
ABCC10 37
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Abcc10 36
  • 85.18 (n)
  • 85.25 (a)
Abcc10 16
Abcc10 37
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ABCC10 37
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ABCC10 37
  • 72 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Abcc10 36
  • 85.35 (n)
  • 85.97 (a)
chicken
(Gallus gallus)
Aves ABCC10 36
  • 64.27 (n)
  • 62.7 (a)
ABCC10 37
  • 61 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ABCC10 37
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100216149 36
  • 59.55 (n)
  • 57.24 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6670 36
zebrafish
(Danio rerio)
Actinopterygii Dr.16618 36
LOC556709 36
  • 60.06 (n)
  • 57.06 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007917 36
  • 49.5 (n)
  • 43.4 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7806 36
  • 48.51 (n)
  • 42.32 (a)
CG7806 37
  • 38 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes BPT1 37
  • 29 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons MRP11 36
  • 46.91 (n)
  • 40.72 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10668 37
  • 42 (a)
OneToOne
Species with no ortholog for ABCC10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ABCC10 Gene

ENSEMBL:
Gene Tree for ABCC10 (if available)
TreeFam:
Gene Tree for ABCC10 (if available)

Paralogs for ABCC10 Gene

genes like me logo Genes that share paralogs with ABCC10: view

No data available for Paralogs for ABCC10 Gene

Variants for ABCC10 Gene

Sequence variations from dbSNP and Humsavar for ABCC10 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs700008 -- 43,432,099(+) TCCTG(A/G)GTCAG intron-variant, utr-variant-5-prime
rs831311 -- 43,437,927(-) TGCAA(A/G)GAAGC intron-variant
rs831312 -- 43,437,787(-) TCTCC(A/G)CTTCA intron-variant
rs864392 -- 43,436,054(-) GCCAG(C/G)CCCAT intron-variant
rs1214746 -- 43,446,478(+) CCTCA(C/T)CCACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ABCC10 Gene

Variant ID Type Subtype PubMed ID
dgv6841n71 CNV Loss 21882294

Relevant External Links for ABCC10 Gene

HapMap Linkage Disequilibrium report
ABCC10

Disorders for ABCC10 Gene

(1) Novoseek inferred disease relationships for ABCC10 Gene

Disease -log(P) Hits PubMed IDs
cancer 11.4 1

Relevant External Links for ABCC10

Genetic Association Database (GAD)
ABCC10
Human Genome Epidemiology (HuGE) Navigator
ABCC10
genes like me logo Genes that share disorders with ABCC10: view

No data available for UniProtKB/Swiss-Prot for ABCC10 Gene

Publications for ABCC10 Gene

  1. Genomic structure, gene expression, and promoter analysis of human multidrug resistance-associated protein 7. (PMID: 12566991) Kao H.-H. … Huang J.-D. (J. Biomed. Sci. 2003) 3 4 23
  2. Analysis of the drug resistance profile of multidrug resistance protein 7 (ABCC10): resistance to docetaxel. (PMID: 15256465) Hopper-Borge E. … Kruh G.D. (Cancer Res. 2004) 3 4 23
  3. Human multidrug resistance protein 7 (ABCC10) is a resistance factor for nucleoside analogues and epothilone B. (PMID: 19118001) Hopper-Borge E. … Kruh G.D. (Cancer Res. 2009) 3 23 25
  4. Cepharanthine is a potent reversal agent for MRP7(ABCC10)-mediated multidrug resistance. (PMID: 19150344) Zhou Y. … Chen Z.S. (Biochem. Pharmacol. 2009) 3 23 25
  5. Characterization of the transport properties of human multidrug resistance protein 7 (MRP7, ABCC10). (PMID: 12527806) Chen Z.-S. … Kruh G.D. (Mol. Pharmacol. 2003) 3 4 25

Products for ABCC10 Gene

Sources for ABCC10 Gene

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