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ABCC10 Gene

protein-coding   GIFtS: 59
GCID: GC06P043396

ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 1...

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 101 2
MRP72 3 5
SIMRP72 3
ATP-Binding Cassette Sub-Family C Member 102 3
EST1827632
Multidrug Resistance-Associated Protein 72

External Ids:    HGNC: 521   Entrez Gene: 898452   Ensembl: ENSG000001245747   OMIM: 6125095   UniProtKB: Q5T3U53   

Export aliases for ABCC10 gene to outside databases

Previous GC identifers: GC06U990186 GC06P043391 GC06P043442 GC06P043503 GC06P043117


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ABCC10 Gene:
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC
proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven
distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This ABC full-transporter is a member of
the MRP subfamily which is involved in multi-drug resistance. Multiple transcript variants encoding different
isoforms have been found for this gene.(provided by RefSeq, Nov 2010)

GeneCards Summary for ABCC10 Gene:
ABCC10 (ATP-binding cassette, sub-family C (CFTR/MRP), member 10) is a protein-coding gene. Diseases associated with ABCC10 include cftr-related disorders, and was-related disorders. GO annotations related to this gene include ATPase activity, coupled to transmembrane movement of substances.

UniProtKB/Swiss-Prot: MRP7_HUMAN, Q5T3U5
Function: ATP-dependent transporter probably involved in cellular detoxification through lipophilic anion
extrusion

Gene Wiki entry for ABCC10 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000006.12  NT_007592.16  NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ABCC10 gene promoter:
         NF-1/L   Spz1   Sp1   LCR-F1   C/EBPalpha   E47   HEN1   AREB6   HFH-1   Hand1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ABCC10 promoter sequence
   Search Chromatin IP Primers for ABCC10

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ABCC10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.1   Ensembl cytogenetic band:  6p21.1   HGNC cytogenetic band: 6p12.3

ABCC10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ABCC10 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P043396:  view genomic region     (about GC identifiers)

Start:
43,395,104 bp from pter      End:
43,418,168 bp from pter
Size:
23,065 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MRP7_HUMAN, Q5T3U5 (See protein sequence)
Recommended Name: Multidrug resistance-associated protein 7  
Size: 1492 amino acids; 161629 Da
Sequence caution: Sequence=BAA92227.1; Type=Erroneous initiation; Sequence=BAB15736.1; Type=Miscellaneous
discrepancy; Note=Intron retention;
Secondary accessions: Q8NHX7 Q9H7N2 Q9NXY3 Q9UF48
Alternative splicing: 2 isoforms:  Q5T3U5-1   Q5T3U5-2   

Explore the universe of human proteins at neXtProt for ABCC10: NX_Q5T3U5

Explore proteomics data for ABCC10 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys460, Lys664, Lys688
  • Modification sites at PhosphoSitePlus

  • See ABCC10 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001185863.1  NP_258261.2  

    ENSEMBL proteins: 
     ENSP00000361593   ENSP00000361608   ENSP00000244533   ENSP00000422699  
    Reactome Protein details: Q5T3U5

    ABCC10 Human Recombinant Protein Products:

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    Novus Biologicals ABCC10 Protein
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    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for ABCC10

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    Cloud-Clone Corp. CLIAs for ABCC10


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ABCC: ATP binding cassette transporters / subfamily C

    IUPHAR Guide to PHARMACOLOGY protein family classification: ABCC10
    ABCC subfamily

    Selected InterPro protein domains (see all 6):
     IPR003439 ABC_transporter-like
     IPR027417 P-loop_NTPase
     IPR001140 ABC_transptr_TM_dom
     IPR003593 AAA+_ATPase
     IPR011527 ABC1_TM_dom

    Graphical View of Domain Structure for InterPro Entry Q5T3U5

    ProtoNet protein and cluster: Q5T3U5

    UniProtKB/Swiss-Prot: MRP7_HUMAN, Q5T3U5
    Similarity: Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208)
    subfamily
    Similarity: Contains 2 ABC transmembrane type-1 domains
    Similarity: Contains 2 ABC transporter domains


    ABCC10 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MRP7_HUMAN, Q5T3U5
    Function: ATP-dependent transporter probably involved in cellular detoxification through lipophilic anion
    extrusion
    Biophysicochemical properties: Kinetic parameters: KM=57.8 uM for 17-beta-estradiol 17-(beta-D-glucuronide) (at 37
    degrees Celsius); Vmax=20 pmol/min/mg enzyme toward 17-beta-estradiol 17-(beta-D- glucuronide) (at 37 degrees
    Celsius);

         Genatlas biochemistry entry for ABCC10:
    ATP binding cassettte superfamily,subfamily C (CFTR/MRP),member 10

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding ----
    GO:0005524ATP binding IEA--
    GO:0016887ATPase activity ----
    GO:0017111nucleoside-triphosphatase activity ----
    GO:0042626ATPase activity, coupled to transmembrane movement of substances IEA--
         
    ABCC10 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for ABCC10:
     Decreased number of cells in m  Increased viability after born 

         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Abcc10):
     growth/size/body  hematopoietic system  homeostasis/metabolism  immune system  mortality/aging 

    ABCC10 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Abcc10tm1Eah for ABCC10

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ABCC10
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ABCC10
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ABCC10

    miRNA
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    miRTarBase miRNAs that target ABCC10:
    hsa-mir-183-5p (MIRT047155)

    Block miRNA regulation of human, mouse, rat ABCC10 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ABCC10 (see all 17):
    hsa-let-7d hsa-let-7c hsa-miR-374a* hsa-miR-374c hsa-let-7g hsa-let-7a hsa-miR-98 hsa-miR-3671
    SwitchGear 3'UTR luciferase reporter plasmidABCC10 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ABCC10

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MRP7_HUMAN, Q5T3U5: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    endoplasmic reticulum1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005765lysosomal membrane IDA17897319
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--

    ABCC10 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ABCC10 About    
    See pathways by source

    SuperPathContained pathways About
    1ABC-family proteins mediated transport
    ABC-family proteins mediated transport0.69
    ABC transporters0.69
    2Venlafaxine Pathway, Pharmacokinetics
    Nevirapine Pathway, Pharmacokinetics0.50
    3Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    Transmembrane transport of small molecules0.47
    4Vinka Alkaloid Pathway, Pharmacokinetics
    Vinka Alkaloid Pathway, Pharmacokinetics
    5Tenofovir/Adefovir Pathway, Pharmacokinetics
    Tenofovir/Adefovir Pathway, Pharmacokinetics

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for ABCC10
        ABC-family proteins mediated transport

    3 PharmGKB Pathways for ABCC10
        Nevirapine Pathway, Pharmacokinetics
    Tenofovir/Adefovir Pathway, Pharmacokinetics
    Vinka Alkaloid Pathway, Pharmacokinetics

    1 Kegg Pathway  (Kegg details for ABCC10):
        ABC transporters


    ABCC10 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including ABCC10: 
              Drug Transporters in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for ABCC10

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    Selected Interacting proteins for ABCC10 (ENSP000002445334) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCENSP000003448184STRING: ENSP00000344818
    ETS1ENSP000003764364STRING: ENSP00000376436
    ETS2ENSP000003533444STRING: ENSP00000353344
    SLC35F5ENSP000002456804STRING: ENSP00000245680
    ABCB6ENSP000002653164STRING: ENSP00000265316
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport ----
    GO:0055085transmembrane transport TAS--

    ABCC10 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ABCC10 (MRP7)

    Selected DrugBank Compounds for ABCC10 (see all 15)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Paclitaxel7-epi-Paclitaxel (see all 8)33069-62-4transportersubstrate inhibitor19118001 12527806 19150344
    EtoposideEPEG (see all 4)33419-42-0transportersubstrate inhibitor19118001 12527806
    Vincristine22-Oxovincaleukoblastine (see all 12)57-22-7transportersubstrate inhibitor19118001 12527806
    CyclosporineCiclosporin (see all 4)59865-13-3transporterinhibitor12527806
    CytarabineAra-C (see all 26)147-94-4transportersubstrate19118001
    Daunorubicin-- 20830-81-3transportersubstrate19118001
    DocetaxelDocetaxel anhydrous (see all 4)114977-28-5transportersubstrate19118001
    DoxorubicinAdria (see all 4)23214-92-8transporterinhibitor12527806
    Estradiol17beta oestradiol (see all 7)50-28-2transporterinhibitor12527806
    GemcitabinedFdC (see all 4)95058-81-4transportersubstrate19118001

    4 Novoseek inferred chemical compound relationships for ABCC10 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    estradiol-17beta-glucuronide 85 1 17203221 (1)
    vincristine 63.9 18 17203221 (4), 19118001 (2)
    docetaxel 63.1 11 17203221 (3), 19118001 (2), 15256465 (1), 19720054 (1)
    paclitaxel 51.9 7 18445659 (6), 19841739 (2), 19118001 (2), 19720054 (1)

    1 PharmGKB related drug/compound annotation for ABCC10 gene    About this table
    Drug/compound PharmGKB Annotation
    tenofovirCA  



    ABCC10 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ABCC10 gene (2 alternative transcripts): 
    NM_001198934.1  NM_033450.2  

    Unigene Cluster for ABCC10:

    ATP-binding cassette, sub-family C (CFTR/MRP), member 10
    Hs.55879  [show with all ESTs]
    Unigene Representative Sequence: NM_033450
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000372515 ENST00000502549 ENST00000372530(uc003ouy.1) ENST00000443426
    ENST00000244533(uc003ouz.1) ENST00000463024(uc010jyo.1) ENST00000469856
    ENST00000372512 ENST00000437104 ENST00000505344
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate ABCC10 (see all 17):
    hsa-let-7d hsa-let-7c hsa-miR-374a* hsa-miR-374c hsa-let-7g hsa-let-7a hsa-miR-98 hsa-miR-3671
    SwitchGear 3'UTR luciferase reporter plasmidABCC10 3' UTR sequence
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ABCC10
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      QuantiFast Probe-based Assays in human, mouse, rat ABCC10

    Additional mRNA sequence: 

    AK000002.1 AK024446.1 AL122095.1 AL133613.1 AY032599.1 BC024103.1 

    14 DOTS entries:

    DT.411217  DT.121405800  DT.100785771  DT.205330  DT.100785775  DT.100785772  DT.101971906  DT.95191036 
    DT.100678325  DT.102842105  DT.121405582  DT.91921778  DT.97792295  DT.91989261 

    Selected AceView cDNA sequences (see all 99):

    BQ101051 AL133613 CK823092 AK024446 AA872614 CR598420 BM352750 BC024103 
    BU856523 BQ927118 NM_033450 BX295257 AL122095 BQ101068 BE504183 BU557035 
    AI279844 AK000002 BG333390 BQ002433 BF222628 BX295260 BX295256 BG697359 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ABCC10 (see all 12)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14a · 14b · 14c ^ 15 ^ 16 ^ 17a · 17b ^ 18a ·
    SP1:                                                                                -                             -                                             
    SP2:                                                                                -                                                                           
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                -                                                                                                                           

    ExUns: 18b · 18c ^ 19a · 19b · 19c ^ 20 ^ 21 ^ 22 ^ 23
    SP1:                                                      
    SP2:                                                      
    SP3:        -                                             
    SP4:                                                      
    SP5:                                                      


    ECgene alternative splicing isoforms for ABCC10

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ABCC10 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ABCC10 Expression
    About this image

    ABCC10 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ABCC10 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.55879

    UniProtKB/Swiss-Prot: MRP7_HUMAN, Q5T3U5
    Tissue specificity: Isoform 1 is specifically expressed in spleen. Isoform 2 is more widely expressed

        Pathway & Disease-focused RT2 Profiler PCR Array including ABCC10: 
              Drug Transporters in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ABCC10

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ABCC10 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Abcc101 , 5 ATP-binding cassette, sub-family C (CFTR/MRP), member 10 less1, 5 85.18(n)1
    85.25(a)1
      17 (22.90 cM)5
    2248141  NM_170680.21  NP_733780.11 
     463032215 
    chicken
    (Gallus gallus)
    Aves ABCC101 ATP-binding cassette, sub-family C (CFTR/MRP), member 10 less 64.27(n)
    62.7(a)
      421456  XM_004935403.1  XP_004935460.1 
    lizard
    (Anolis carolinensis)
    Reptilia ABCC106
    ATP-binding cassette, sub-family C (CFTR/MRP), mem...
    58(a)
    1 ↔ 1
    1(231265368-231291840)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1002161491 uncharacterized LOC100216149 59.55(n)
    57.24(a)
      100216149  NM_001142122.1  NP_001135594.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.166182 Transcribed sequence with weak similarity to protein pirT43469 (H.sapiens) T43469 hypothetical protein DKFZp434L0827.1 - human (fragment) less 77.46(n)    57094294 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG78061 CG7806 48.51(n)
    42.32(a)
      34140  NM_135363.3  NP_609207.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes BPT16
    ABC type transmembrane transporter of MRP/CFTR fam...
    29(a)
    1 ↔ 1
    XII(116432-121111) YLL015W
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons MRP111 MRP11 46.91(n)
    40.72(a)
      815414  NM_126770.7  NP_178811.7 


    ENSEMBL Gene Tree for ABCC10 (if available)
    TreeFam Gene Tree for ABCC10 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ABCC10 gene
    Selected SIMAP similar genes for ABCC10 using alignment to 3 protein entries:     MRP7_HUMAN (see all proteins) (see all similar genes):
    DKFZp434I2115    NG-TRA    ABCB4    TAP1    ABCC1    ABCB5
    ABCB9    DKFZp781G125    MOAT-B    mrp 7    ABCC9    CFTR
    ABCC2    ABCC4    ABCC3    MRP3    ABCC5    ABCC12

    ABCC10 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for ABCC10 (see all 731)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs94720461,2
    A--43393323(+) aaatcA/Ggattg 1 -- us2k10--------
    rs1435658291,2
    --43393481(+) TTAAAC/TGGATT 1 -- us2k10--------
    rs1925023501,2
    --43393673(+) ATTGTC/TTTATG 1 -- us2k10--------
    rs77644031,2
    A--43393720(+) aatgaG/Tcaata 1 -- us2k10--------
    rs717828771,2
    C--43393727(+) AATAAAAAT/-  
            
    AAATA
    1 -- us2k11Minor allele frequency- -:0.50CSA 2
    rs676447591,2
    C--43393746(-) AGTTT-/TTTA  
            
    TTTAT
    1 -- us2k11Minor allele frequency- TTTA:0.00NA 2
    rs1839428221,2
    --43393836(+) TTCACA/GGATGG 1 -- us2k10--------
    rs784151831,2
    C,F--43394041(+) TTAATT/GACTAA 1 -- us2k13Minor allele frequency- G:0.11NA 124
    rs1885935211,2
    --43394096(+) GAAAAA/TTAATT 1 -- us2k10--------
    rs754641471,2
    C,F--43394106(+) TCTTGA/GCGTTG 1 -- us2k12Minor allele frequency- G:0.04NA 122

    HapMap Linkage Disequilibrium report for ABCC10 (43395104 - 43418168 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ABCC10:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv6841n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ABCC10
    DNA2.0 Custom Variant and Variant Library Synthesis for ABCC10

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 612509    OMIM disorders: --

    7 diseases for ABCC10:    
    About MalaCards
    cftr-related disorders    was-related disorders    hiv/aids    cystic fibrosis
    lung cancer    adenocarcinoma    malaria


    ABCC10 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for ABCC10 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 11.4 3 19841739 (1)

    Genetic Association Database (GAD): ABCC10
    Human Genome Epidemiology (HuGE) Navigator: ABCC10 (1 document)

    Export disorders for ABCC10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ABCC10 gene, integrated from 10 sources (see all 33):
    (articles sorted by number of sources associating them with ABCC10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of the transport properties of human multidrug resistance protein 7 (MRP7, ABCC10). (PubMed id 12527806)1, 2, 7 Chen Z.-S....Kruh G.D. (Mol. Pharmacol. 2003)
    2. Human multidrug resistance protein 7 (ABCC10) is a resistance factor for nucleoside analogues and epothilone B. (PubMed id 19118001)1, 7, 9 Hopper-Borge E....Kruh G.D. (Cancer Res. 2009)
    3. Genomic structure, gene expression, and promoter analysis of human multidrug resistance-associated protein 7. (PubMed id 12566991)1, 2, 9 Kao H.-H.... Huang J.-D. (J. Biomed. Sci. 2003)
    4. Cepharanthine is a potent reversal agent for MRP7(ABCC10)-mediated multidrug resistance. (PubMed id 19150344)1, 7, 9 Zhou Y....Chen Z.S. (Biochem. Pharmacol. 2009)
    5. Analysis of the drug resistance profile of multidrug resistance protein 7 (ABCC10): resistance to docetaxel. (PubMed id 15256465)1, 2, 9 Hopper-Borge E.... Kruh G.D. (Cancer Res. 2004)
    6. Genetic variants of ABCC10, a novel tenofovir transporter, are associated with kidney tubular dysfunction. (PubMed id 21628669)1, 7 Pushpakom S.P....Owen A. (J. Infect. Dis. 2011)
    7. Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects. (PubMed id 19343046)1, 4 Saito A....Kamatani N. (J. Hum. Genet. 2009)
    8. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    9. Characterization of the human ABC superfamily: isolation and mapping of 21 new genes using the expressed sequence tags database. (PubMed id 8894702)1, 3 Allikmets R....Dean M. (Hum. Mol. Genet. 1996)
    10. Analysis of the structure and expression pattern of MRP7 (ABCC10), a new member of the MRP subfamily. (PubMed id 11146224)1, 9 Hopper E....Kruh G.D. (Cancer Lett. 2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 89845 HGNC: 52 AceView: ABCC10 Ensembl:ENSG00000124574 euGenes: HUgn89845
    ECgene: ABCC10 Kegg: 89845 H-InvDB: ABCC10

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ABCC10 Pharmacogenomics, SNPs, Pathways
    ABCMdbhttp://abcmutations.hegelab.org/proteinDetails?uniprot_id=Q5T3U5

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ABCC10 gene:
    Search GeneIP for patents involving ABCC10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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