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ABCC10 Gene

protein-coding   GIFtS: 56

GC06P043503
ATP-binding cassette, sub-family C (CFTR/MRP), member 10
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases
EST182763 1, 2
MRP7 1, 2, 3, 5
SIMRP7 1, 2, 3
Descriptions
ATP-binding cassette sub-family C member 10 3
ATP-binding cassette, sub-family C (CFTR/MRP), member 10 2
ATP-binding cassette, sub-family C, member 10 2
multidrug resistance-associated protein 7 2
External Ids
HGNC: 521
Entrez Gene: 898452
UniProtKB: Q5T3U53
Ensembl: ENSG000001245747
Search outside databases for aliases for ABCC10 gene

Previous GC identifers: GC06U990186 GC06P043391 GC06P043442

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for ABCC10:
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC)
transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes.
ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and
White). This ABC full-transporter is a member of the MRP subfamily which is involved in multi-drug
resistance. Alternative splicing of this gene results in multiple transcript variants; however,
not all variants have been fully described. [provided by RefSeq]

UniProtKB/Swiss-Prot: MRP7_HUMAN, Q5T3U5
Function: ATP-dependent transporter probably involved in cellular detoxification through lipophilic
anion extrusion

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the ABCC10 gene  

Entrez Gene cytogenetic band: 6p21.1   Ensembl cytogenetic band:  6p21.1   HGNC cytogenetic band: 6p12.3

ABCC10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P043503:     (about GC identifiers)

Start:
43,503,270 bp from pter
End:
43,526,142 bp from pter
Size:
22,873 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000006.10  NT_007592.14  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: MRP7_HUMAN, Q5T3U5 (See protein sequence)
Recommended Name: Multidrug resistance-associated protein 7  
Size: 1492 amino acids; 161629 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Secondary accessions: Q8NHX7 Q9H7N2 Q9NXY3 Q9UF48
Alternative splicing: 3 isoforms:  Q5T3U5-1   Q5T3U5-2   Q5T3U5-3   

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_258261.2  

    ENSEMBL proteins: 
    ENSP00000361593 ENSP00000361590 ENSP00000244533 ENSP00000361608 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (ABCC10)
    Human Recombinant Proteins from Abnova (ABCC10)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    2 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886 plasma membrane IEA--
    GO:0016021 integral to membrane IEA--
    About this table

    Antibodies for ABCC10: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse Antibodies at Sigma-Aldrich
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (ABCC10), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (ABCC10)
    Novus Biologicals Antibodies for ABCC10

    Assays for ABCC10: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    5 InterPro domains/families:
     IPR003593 ATPase_AAA+_core
     IPR003439 ABC_transporter-like
     IPR017940 ABC_transporter_type1
     IPR001140 ABC_TM_transpt
     IPR017871 ABC_transporter_CS


       GeneDecks  ABCC10 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q5T3U5

    ProtoNet protein and cluster: Q5T3U5

    UniProtKB/Swiss-Prot: MRP7_HUMAN, Q5T3U5
    Similarity: Belongs to the ABC transporter family. Conjugate transporter (TC 3.A.1.208) subfamily
    Similarity: Contains 2 ABC transmembrane type-1 domains
    Similarity: Contains 2 ABC transporter domains

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (ABCC10)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (ABCC10)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_033450

                  Applied Biosystems Silencer® siRNAs for ABCC10

                  Sigma-Aldrich siRNA and siRNA Panels for ABCC10  
                         Sigma-Aldrich shRNA for ABCC10  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for ABCC10
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_033450
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_033450
                                     untagged cDNA clone in CMV expression vector: NM_033450 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_033450

    UniProtKB/Swiss-Prot: MRP7_HUMAN, Q5T3U5
    Function: ATP-dependent transporter probably involved in cellular detoxification through lipophilic
    anion extrusion
    Biophysicochemical properties: Kinetic parameters: KM=57.8 uM for 17-beta-estradiol
    17-(beta-D-glucuronide) (at 37 degrees Celsius); Vmax=20 pmol/min/mg enzyme toward
    17-beta-estradiol 17-(beta-D- glucuronide) (at 37 degrees Celsius);

    Genatlas biochemistry entry for ABCC10:
    ATP binding cassettte superfamily,subfamily C (CFTR/MRP),member 10

    4 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166 nucleotide binding IEA--
    GO:0005524 ATP binding IEA--
    GO:0016887 ATPase activity IEA--
    GO:0042626 ATPase activity, coupled to transmembrane movement of substances IEA--
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


    1 Kegg Pathway  (Kegg details for ABCC10):
     hsa02010 ABC transporters

       GeneDecks  ABCC10 for the pathways selected above  
    About GeneDecksing
     Gene Network CentralTM Interacting Genes and Proteins Network for  ABCC10 


    3 Interacting proteins for ABCC10 (ENSP000003616083) via UniProtKB, MINT, and/or STRING
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MRPS7ENSP000002455393STRING (score=.812)
    CD9ENSP000000091803STRING (score=.702)
    ABCA2ENSP000003472053STRING (score=.7)
    About this table

    1 Gene Ontology (GO) biological process term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810 transport IEA--
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for ABCC10
    1 Novoseek chemical compound relationship for ABCC10 gene
    Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    estradiol-17beta-glucuronide 85.93 1 17203221 (1)
    About this table


    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (ABCC10)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (ABCC10)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_033450

                  Sigma-Aldrich siRNA and siRNA Panels for ABCC10  
                         Sigma-Aldrich shRNA for ABCC10  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_033450  

    REFSEQ mRNAs for ABCC10 gene: 

    NM_033450.2   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_033450  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_033450
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_033450
                                     untagged cDNA clone in CMV expression vector: NM_033450 

    Additional cDNA sequence: 

    AK000002.1 AK024446.1 AL122095.1 AL133613.1 AY032599.1 BC024103.1 CR598420.1 

    14 DOTS entries:

    DT.411217  DT.121405800  DT.100785771  DT.205330  DT.100785775  DT.100785772  DT.101971906  DT.100678325 
    DT.102842105  DT.121405582  DT.91921778  DT.95191036  DT.97792295  DT.91989261 

    24/99 AceView cDNA sequences (see all 99 ):

    CR598420 AI279844 BE504183 AL122095 AL133613 BX295257 AK024446 BU856523 
    AK000002 BQ101068 BQ927118 BM352750 CK823092 AA872614 BQ101051 BC024103 
    BU557035 NM_033450 BQ939947 BG832157 BX283696 BG338793 CK300284 CA778336 

    highest scoring ESTs for ABCC10:

    AI004207 AA135879 AA228314 AA230178 AA872614 AI198402 AI279844 AI351588 AI572934 AI866106 

    Unigene Cluster for ABCC10:

    ATP-binding cassette, sub-family C (CFTR/MRP), member 10
    Hs.55879  [show with all ESTs]
    Unigene Representative Sequence: NM_033450


    GeneLoc Exon Structure

    5/12 Alternative Splicing Database (ASD) splice patterns (SP) for ABCC10 (see all 12 )

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14a · 14b · 14c ^ 15 ^ 16 ^ 17a · 17b ^ 18a ·
    SP1:                                                                                -                             -                                             
    SP2:                                                                                -                                                                           
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                -                                                                                                                           

    ExUns: 18b · 18c ^ 19a · 19b · 19c ^ 20 ^ 21 ^ 22 ^ 23
    SP1:                                                      
    SP2:                                                      
    SP3:        -                                             
    SP4:                                                      
    SP5:                                                      

    About this scheme

    ECgene alternative splicing isoforms for ABCC10

    4 Ensembl transcripts including schematic representations:
    ENST00000372515  ENST00000372512  ENST00000244533  ENST00000372530  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    ABCC10 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for ABCC10

    1 / 2 / 3

    7 probe-sets matching ABCC10 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    36731_g_at2, 3 U95-A 1 1.00 1.00 0.81 1.15 U66684 0.60 1.00 0.82 1

    36732_at2, 3 U95-A 1 1.00 1.00 0.93 1.13 AI004207 1.00 1.00 1.00 1

    36730_at2, 3 U95-A 1 0.69 1.00 0.91 0.73 U66684 0.60 1.00 0.82 1

    215873_x_at2, 3 U133-A 1 1.00 1.00 -- -- AK024446 0.80 1.00 0.91 1

    213485_s_at2, 3 U133-A 1 1.00 1.00 -- -- AK000002 0.80 1.00 0.91 1

    215873_x_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    213485_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    About this table
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: --

    SOURCE GeneReport for Unigene cluster: Hs.55879

    Expression variation in blood from EXPOLDB for ABCC10

    UniProtKB/Swiss-Prot: MRP7_HUMAN, Q5T3U5
    Tissue specificity: Isoform 1 is specifically expressed in spleen. Isoform 2 is more widely
    expressed

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for ABCC10 gene from 5/12 species (see all 12 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    ABCC101   -- ATP-binding cassette, sub-family C (CFTR/MRP), member more 88.56(n)
    89.9(a)
    481813  XM_538934.2  XP_538934.2 
    chimpanzee
    (Pan troglodytes)
    ABCC101   -- ATP-binding cassette, sub-family C (CFTR/MRP), member more 99.51(n)
    99.31(a)
    462717  XM_518494.2  XP_518494.2 
    cow
    (Bos taurus)
    ABCC101   -- ATP-binding cassette, sub-family C (CFTR/MRP), member more 88.9(n)
    90.04(a)
    508399  XM_585169.3  XP_585169.3 
    rat
    (Rattus norvegicus)
    Abcc101   -- ATP-binding cassette, sub-family C (CFTR/MRP), member more 85.31(n)
    85.75(a)
    316231  XM_236930.4  XP_236930.4 
    mouse
    (Mus musculus)
    Abcc101, 5 175
    ATP-binding cassette, sub-family C (CFTR/MRP), member more1, 5 84.99(n)1
    84.85(a)1
    2248141  NM_170680.21  NP_733780.11 
     AF4066425  AF4171215  (see all 16)
    About this table        Species with no ortholog for ABCC10

    ENSEMBL Gene Tree for ABCC10
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for ABCC10 gene
    CFTR2  ABCC82  ABCC92  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/92 NCBI SNPs in ABCC10 are shown (see all 92 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 45)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 6 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs7000081,2
    A,C,F,H43507815(+) TCCTGG/AGTCAG 1 -- ut51 ese35Minor allele frequency- A:0.06EU EA WA 1882
    rs21257391,2
    A,C,F,H43520843(+) CAGCAT/CCCCAG 1 T/I mis1 ese38Minor allele frequency- C:0.24EU EA WA 836
    --
    rs43556061,2
    A,C43506665(+) AAACTC/GCTGAT 1 -- ng510--------
    --
    rs74542971,2
    A,C43506549(+) ttctcA/Gtgcct 1 -- ng510--------
    --
    rs119693601,2
    C43505570(+) tgaatC/Tgcttg 1 -- ng510--------
    rs21257401,2
    C,F,H43520913(+) GTGTAT/CGCGAC 1 Y/Y syn1 ese38Minor allele frequency- C:0.08EU EA WA NA 652
    rs22771221,2
    C,F,H43514479(+) AGGTGC/TTAGAA 1 L/L syn1 ese39Minor allele frequency- T:0.10EA EU WA 2328
    rs8313151,2
    A,C,F,H,O43509705(+) GTTGTT/CGACCC 1 -- int15Minor allele frequency- C:0.04EA NA 308
    rs21856311,2
    A,C,F,H43515983(+) TTCGTA/GGGTTT 1 -- int17Minor allele frequency- G:0.48EU EA WA NA 516
    rs8313161,2
    C,F,H,O43509433(-) TTTGGT/AGCCAG 1 -- int18Minor allele frequency- A:0.27EU EA WA NA 740
    About this table

    HapMap Linkage Disequilibrium images for ABCC10 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 612509

    Human Genome Epidemiology Navigator: ABCC10 (1 document)

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/20 PubMed articles for ABCC10 gene (see all 20 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 89845 HGNC: 52 AceView: ABCC10 Ensembl:ENSG00000124574 euGenes: HUgn89845
    ECgene: ABCC10 H-InvDB: ABCC10
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

      --
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for ABCC10:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



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     Predesigned and custom siRNAs for ABCC10 Browse antibodies at Sigma-Aldrich
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for ABCC10 Browse small molecules at Sigma-Aldrich
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     Antibodies for ABCC10

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