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Aliases for ABCC10 Gene

Aliases for ABCC10 Gene

  • ATP Binding Cassette Subfamily C Member 10 2 3 5
  • ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 10 2 3
  • ATP-Binding Cassette Sub-Family C Member 10 3 4
  • SIMRP7 3 4
  • MRP7 3 4
  • Multidrug Resistance-Associated Protein 7 3
  • EST182763 3

External Ids for ABCC10 Gene

Previous GeneCards Identifiers for ABCC10 Gene

  • GC06U990186
  • GC06P043391
  • GC06P043442
  • GC06P043503
  • GC06P043117
  • GC06P043396

Summaries for ABCC10 Gene

Entrez Gene Summary for ABCC10 Gene

  • The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This ABC full-transporter is a member of the MRP subfamily which is involved in multi-drug resistance. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Nov 2010]

GeneCards Summary for ABCC10 Gene

ABCC10 (ATP Binding Cassette Subfamily C Member 10) is a Protein Coding gene. Diseases associated with ABCC10 include Congenital Bilateral Absence Of Vas Deferens and Bronchiectasis With Or Without Elevated Sweat Chloride 1. Among its related pathways are ABC-family proteins mediated transport and Vinka Alkaloid Pathway, Pharmacokinetics. GO annotations related to this gene include ATPase activity and ATPase activity, coupled to transmembrane movement of substances. An important paralog of this gene is ABCC2.

UniProtKB/Swiss-Prot for ABCC10 Gene

  • ATP-dependent transporter probably involved in cellular detoxification through lipophilic anion extrusion.

Gene Wiki entry for ABCC10 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ABCC10 Gene

Genomics for ABCC10 Gene

Regulatory Elements for ABCC10 Gene

Enhancers for ABCC10 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around ABCC10 on UCSC Golden Path with GeneCards custom track

Promoters for ABCC10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for ABCC10 Gene

Chromosome:
6
Start:
43,427,366 bp from pter
End:
43,451,980 bp from pter
Size:
24,615 bases
Orientation:
Plus strand

Genomic View for ABCC10 Gene

Genes around ABCC10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ABCC10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ABCC10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ABCC10 Gene

Proteins for ABCC10 Gene

  • Protein details for ABCC10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T3U5-MRP7_HUMAN
    Recommended name:
    Multidrug resistance-associated protein 7
    Protein Accession:
    Q5T3U5
    Secondary Accessions:
    • Q8NHX7
    • Q9H7N2
    • Q9NXY3
    • Q9UF48

    Protein attributes for ABCC10 Gene

    Size:
    1492 amino acids
    Molecular mass:
    161629 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA92227.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB15736.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};

    Alternative splice isoforms for ABCC10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ABCC10 Gene

Post-translational modifications for ABCC10 Gene

  • Ubiquitination at Lys 460, Lys 664, and Lys 688
  • Modification sites at PhosphoSitePlus

Other Protein References for ABCC10 Gene

No data available for DME Specific Peptides for ABCC10 Gene

Domains & Families for ABCC10 Gene

Gene Families for ABCC10 Gene

Protein Domains for ABCC10 Gene

Graphical View of Domain Structure for InterPro Entry

Q5T3U5

UniProtKB/Swiss-Prot:

MRP7_HUMAN :
  • Contains 2 ABC transmembrane type-1 domains.
  • Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
Domain:
  • Contains 2 ABC transmembrane type-1 domains.
  • Contains 2 ABC transporter domains.
Family:
  • Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
genes like me logo Genes that share domains with ABCC10: view

Function for ABCC10 Gene

Molecular function for ABCC10 Gene

GENATLAS Biochemistry:
ATP binding cassettte superfamily,subfamily C (CFTR/MRP),member 10
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=57.8 uM for 17-beta-estradiol 17-(beta-D-glucuronide) (at 37 degrees Celsius) {ECO:0000269 PubMed:12527806}; Vmax=20 pmol/min/mg enzyme toward 17-beta-estradiol 17-(beta-D- glucuronide) (at 37 degrees Celsius) {ECO:0000269 PubMed:12527806};
UniProtKB/Swiss-Prot Function:
ATP-dependent transporter probably involved in cellular detoxification through lipophilic anion extrusion.

Gene Ontology (GO) - Molecular Function for ABCC10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
GO:0043225 anion transmembrane-transporting ATPase activity TAS --
genes like me logo Genes that share ontologies with ABCC10: view
genes like me logo Genes that share phenotypes with ABCC10: view

Animal Models for ABCC10 Gene

MGI Knock Outs for ABCC10:

Animal Model Products

  • Taconic Biosciences Mouse Models for ABCC10

CRISPR Products

miRNA for ABCC10 Gene

miRTarBase miRNAs that target ABCC10

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ABCC10 Gene

Localization for ABCC10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ABCC10 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ABCC10 Gene COMPARTMENTS Subcellular localization image for ABCC10 gene
Compartment Confidence
lysosome 5
plasma membrane 5
vacuole 5
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for ABCC10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005765 lysosomal membrane IDA 17897319
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ABCC10: view

Pathways & Interactions for ABCC10 Gene

genes like me logo Genes that share pathways with ABCC10: view

Pathways by source for ABCC10 Gene

Gene Ontology (GO) - Biological Process for ABCC10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0055085 transmembrane transport TAS --
GO:0098656 anion transmembrane transport IEA --
genes like me logo Genes that share ontologies with ABCC10: view

No data available for SIGNOR curated interactions for ABCC10 Gene

Drugs & Compounds for ABCC10 Gene

(22) Drugs for ABCC10 Gene - From: DrugBank, PharmGKB, FDA Approved Drugs, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Docetaxel Approved May 1996, Investigational Pharma Transporter, substrate Microtubulin disassembly inhibitor, Tubulin and VEGF inhibitor, Taxanes, Microtubule stabilizer 1880
Tenofovir Approved, Investigational Pharma Transporter, substrate HIV reverse transcriptase inhibitor 709
Paclitaxel Approved, Vet_approved Pharma Transporter, substrate, inhibitor Tubulin and Bcl2 inhibitor, Taxanes 2691
Vincristine Approved, Investigational Pharma Transporter, substrate, inhibitor Microtubule disrupter,antitumor agent 888
Cyclosporin A Approved, Investigational, Vet_approved Pharma Antagonist, Transporter, inhibitor Immunosuppressant drug, Immunosuppressive agent, Calcineurin inhibitor 0

(1) Additional Compounds for ABCC10 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ABCC10: view

Transcripts for ABCC10 Gene

Unigene Clusters for ABCC10 Gene

ATP-binding cassette, sub-family C (CFTR/MRP), member 10:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ABCC10 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14a · 14b · 14c ^ 15 ^ 16 ^ 17a · 17b ^ 18a ·
SP1: - -
SP2: -
SP3:
SP4:
SP5: -
SP6: -
SP7:
SP8:
SP9: -
SP10:
SP11: - - - -
SP12:

ExUns: 18b · 18c ^ 19a · 19b · 19c ^ 20 ^ 21 ^ 22 ^ 23
SP1:
SP2:
SP3: -
SP4:
SP5:
SP6:
SP7: -
SP8: -
SP9:
SP10:
SP11:
SP12:

Relevant External Links for ABCC10 Gene

GeneLoc Exon Structure for
ABCC10
ECgene alternative splicing isoforms for
ABCC10

Expression for ABCC10 Gene

mRNA expression in normal human tissues for ABCC10 Gene

Protein differential expression in normal tissues from HIPED for ABCC10 Gene

This gene is overexpressed in Monocytes (25.2), Tlymphocyte (19.3), Liver (9.5), and Ovary (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ABCC10 Gene



Protein tissue co-expression partners for ABCC10 Gene

NURSA nuclear receptor signaling pathways regulating expression of ABCC10 Gene:

ABCC10

SOURCE GeneReport for Unigene cluster for ABCC10 Gene:

Hs.55879

mRNA Expression by UniProt/SwissProt for ABCC10 Gene:

Q5T3U5-MRP7_HUMAN
Tissue specificity: Isoform 1 is specifically expressed in spleen. Isoform 2 is more widely expressed.
genes like me logo Genes that share expression patterns with ABCC10: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ABCC10 Gene

Orthologs for ABCC10 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ABCC10 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ABCC10 34
  • 88.8 (n)
  • 89.78 (a)
ABCC10 35
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ABCC10 34
  • 88.53 (n)
  • 89.6 (a)
ABCC10 35
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Abcc10 34
  • 85.18 (n)
  • 85.25 (a)
Abcc10 16
Abcc10 35
  • 84 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ABCC10 34
  • 99.55 (n)
  • 99.33 (a)
ABCC10 35
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Abcc10 34
  • 85.35 (n)
  • 85.97 (a)
oppossum
(Monodelphis domestica)
Mammalia ABCC10 35
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ABCC10 35
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves ABCC10 34
  • 64.27 (n)
  • 62.7 (a)
ABCC10 35
  • 61 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ABCC10 35
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100216149 34
  • 59.55 (n)
  • 57.24 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.16618 34
LOC556709 34
  • 60.06 (n)
  • 57.06 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6670 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007917 34
  • 49.5 (n)
  • 43.4 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7806 34
  • 48.51 (n)
  • 42.32 (a)
CG7806 35
  • 38 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes BPT1 35
  • 29 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons MRP11 34
  • 46.91 (n)
  • 40.72 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10668 35
  • 42 (a)
OneToOne
Species where no ortholog for ABCC10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ABCC10 Gene

ENSEMBL:
Gene Tree for ABCC10 (if available)
TreeFam:
Gene Tree for ABCC10 (if available)

Paralogs for ABCC10 Gene

Paralogs for ABCC10 Gene

genes like me logo Genes that share paralogs with ABCC10: view

Variants for ABCC10 Gene

Sequence variations from dbSNP and Humsavar for ABCC10 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs2125739 - 43,445,127(+) CAGCA(C/T)CCCAG nc-transcript-variant, downstream-variant-500B, reference, missense
rs831311 -- 43,437,927(-) TGCAA(A/G)GAAGC intron-variant, upstream-variant-2KB
rs831312 -- 43,437,787(-) TCTCC(A/G)CTTCA intron-variant, upstream-variant-2KB
rs864392 -- 43,436,054(-) GCCAG(C/G)CCCAT intron-variant, upstream-variant-2KB
rs4714684 -- 43,429,118(+) GGGTT(A/C)GAGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ABCC10 Gene

Variant ID Type Subtype PubMed ID
esv3416007 CNV duplication 20981092
nsv603000 CNV loss 21841781
nsv950172 CNV deletion 24416366

Variation tolerance for ABCC10 Gene

Residual Variation Intolerance Score: 21.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.54; 86.02% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ABCC10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ABCC10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ABCC10 Gene

Disorders for ABCC10 Gene

MalaCards: The human disease database

(4) MalaCards diseases for ABCC10 Gene - From: OMIM

Disorder Aliases PubMed IDs
congenital bilateral absence of vas deferens
  • vas deferens, congenital bilateral aplasia of
bronchiectasis with or without elevated sweat chloride 1
  • bronchiectasis with or without elevated sweat chloride 1, modifier of
pancreatitis, hereditary
  • pancreatitis, chronic
cystic fibrosis
  • pseudomonas aeruginosa chronic infection by, in cystic fibrosis
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ABCC10

Genetic Association Database (GAD)
ABCC10
Human Genome Epidemiology (HuGE) Navigator
ABCC10
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ABCC10
genes like me logo Genes that share disorders with ABCC10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ABCC10 Gene

Publications for ABCC10 Gene

  1. Analysis of the drug resistance profile of multidrug resistance protein 7 (ABCC10): resistance to docetaxel. (PMID: 15256465) Hopper-Borge E. … Kruh G.D. (Cancer Res. 2004) 3 4 22 65
  2. Genomic structure, gene expression, and promoter analysis of human multidrug resistance-associated protein 7. (PMID: 12566991) Kao H.-H. … Huang J.-D. (J. Biomed. Sci. 2003) 3 4 22 65
  3. Lapatinib and erlotinib are potent reversal agents for MRP7 (ABCC10)-mediated multidrug resistance. (PMID: 19720054) Kuang Y.H. … Chen Z.S. (Biochem. Pharmacol. 2010) 3 22 65
  4. Human multidrug resistance protein 7 (ABCC10) is a resistance factor for nucleoside analogues and epothilone B. (PMID: 19118001) Hopper-Borge E. … Kruh G.D. (Cancer Res. 2009) 3 22 65
  5. Cepharanthine is a potent reversal agent for MRP7(ABCC10)-mediated multidrug resistance. (PMID: 19150344) Zhou Y. … Chen Z.S. (Biochem. Pharmacol. 2009) 3 22 65

Products for ABCC10 Gene

Sources for ABCC10 Gene

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