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Aliases & Descriptions for ABCC10
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| EST182763 1, 2 | | MRP7 1, 2, 3, 5 | | SIMRP7 1, 2, 3 |
| | | Descriptions |
|---|
| ATP-binding cassette sub-family C member 10 3 | | ATP-binding cassette, sub-family C (CFTR/MRP), member 10 2 | | ATP-binding cassette, sub-family C, member 10 2 | | multidrug resistance-associated protein 7 2 |
|
| | Search outside databases for aliases for ABCC10 genePrevious GC identifers: GC06U990186 GC06P043391 GC06P043442 |
Summaries for ABCC10(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for ABCC10: The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This ABC full-transporter is a member of the MRP subfamily which is involved in multi-drug resistance. Alternative splicing of this gene results in multiple transcript variants; however, not all variants have been fully described. [provided by RefSeq] UniProtKB/Swiss-Prot: MRP7_HUMAN, Q5T3U5Function: ATP-dependent transporter probably involved in cellular detoxification through lipophilic anion extrusion |
Genomic Location for ABCC10
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the ABCC10 gene 
Entrez Gene cytogenetic band: 6p21.1 Ensembl cytogenetic band: 6p21.1 HGNC cytogenetic band: 6p12.3ABCC10 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06P043503:
(about GC identifiers)
Start:
|
43,503,270 bp from pter |
End:
|
43,526,142 bp from pter |
Size:
|
22,873 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000006.10 NT_007592.14
| Proteins for ABCC10
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: MRP7_HUMAN, Q5T3U5 (See
protein sequence)Recommended Name: Multidrug resistance-associated protein 7 Size: 1492 amino acids; 161629 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Secondary accessions: Q8NHX7 Q9H7N2 Q9NXY3 Q9UF48Alternative splicing: 3 isoforms: Q5T3U5-1 Q5T3U5-2 Q5T3U5-3 Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_258261.2
ENSEMBL proteins: ENSP00000361593 ENSP00000361590 ENSP00000244533 ENSP00000361608
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
2 Gene Ontology (GO) cellular component terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005886 | plasma membrane |
IEA | -- | | GO:0016021 | integral to membrane |
IEA | -- | About this table
Antibodies for ABCC10: Assays for ABCC10: | Protein
Domains/ Families for ABCC10(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q5T3U5
ProtoNet protein and cluster: Q5T3U5 UniProtKB/Swiss-Prot: MRP7_HUMAN, Q5T3U5Similarity: Belongs to the ABC transporter family. Conjugate transporter (TC 3.A.1.208) subfamilySimilarity: Contains 2 ABC transmembrane type-1 domainsSimilarity: Contains 2 ABC transporter domains | Gene Function for ABCC10
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_033450
Applied Biosystems Silencer® siRNAs for ABCC10
Sigma-Aldrich siRNA and siRNA Panels for ABCC10  Sigma-Aldrich shRNA for ABCC10  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_033450                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_033450                                  untagged cDNA clone in CMV expression vector: NM_033450 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_033450
UniProtKB/Swiss-Prot: MRP7_HUMAN, Q5T3U5Function: ATP-dependent transporter probably involved in cellular detoxification through lipophilic anion extrusionBiophysicochemical properties: Kinetic parameters: KM=57.8 uM for 17-beta-estradiol 17-(beta-D-glucuronide) (at 37 degrees Celsius); Vmax=20 pmol/min/mg enzyme toward 17-beta-estradiol 17-(beta-D- glucuronide) (at 37 degrees Celsius);Genatlas biochemistry entry for ABCC10:ATP binding cassettte superfamily,subfamily C (CFTR/MRP),member 104 Gene Ontology (GO) molecular function terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000166 | nucleotide binding |
IEA | -- | | GO:0005524 | ATP binding |
IEA | -- | | GO:0016887 | ATPase activity |
IEA | -- | | GO:0042626 | ATPase activity, coupled to transmembrane movement of substances |
IEA | -- | About this table | Pathways & Interactions for ABCC10
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
Gene Network CentralTM Interacting Genes and Proteins Network for ABCC10 
3 Interacting proteins for ABCC10 (ENSP000003616083) via UniProtKB, MINT, and/or STRINGAbout this table
1 Gene Ontology (GO) biological process term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006810 | transport |
IEA | -- | About this table
|
Drugs & Compounds for ABCC10(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for ABCC10 1 Novoseek chemical compound relationship for ABCC10 gene
About this table
|
Transcripts for ABCC10(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_033450
Sigma-Aldrich siRNA and siRNA Panels for ABCC10  Sigma-Aldrich shRNA for ABCC10  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_033450 REFSEQ mRNAs for ABCC10 gene: NM_033450.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_033450               OriGene GFP tagged cDNA clone in CMV expression vector: NM_033450                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_033450                                  untagged cDNA clone in CMV expression vector: NM_033450  Additional cDNA sequence: AK000002.1 AK024446.1 AL122095.1 AL133613.1 AY032599.1 BC024103.1 CR598420.1 14 DOTS entries: DT.411217 DT.121405800 DT.100785771 DT.205330 DT.100785775 DT.100785772 DT.101971906 DT.100678325 DT.102842105 DT.121405582 DT.91921778 DT.95191036 DT.97792295 DT.91989261 24/99 AceView cDNA sequences (see all 99
):CR598420 AI279844 BE504183 AL122095 AL133613 BX295257 AK024446 BU856523 AK000002 BQ101068 BQ927118 BM352750 CK823092 AA872614 BQ101051 BC024103 BU557035 NM_033450 BQ939947 BG832157 BX283696 BG338793 CK300284 CA778336
highest scoring ESTs for ABCC10:AI004207 AA135879 AA228314 AA230178 AA872614 AI198402 AI279844 AI351588 AI572934 AI866106 Unigene Cluster for ABCC10: ATP-binding cassette, sub-family C (CFTR/MRP), member 10 Hs.55879 [show with all ESTs]Unigene Representative Sequence: NM_033450
GeneLoc Exon Structure
5/12 Alternative Splicing Database (ASD) splice patterns (SP) for ABCC10 (see all 12
)
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12a | · | 12b | ^ | 13 | ^ | 14a | · | 14b | · | 14c | ^ | 15 | ^ | 16 | ^ | 17a | · | 17b | ^ | 18a | · | |
| SP1: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
| ExUns: | 18b | · | 18c | ^ | 19a | · | 19b | · | 19c | ^ | 20 | ^ | 21 | ^ | 22 | ^ | 23 | |
| SP1: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for ABCC10
4 Ensembl transcripts including schematic representations: ENST00000372515
ENST00000372512
ENST00000244533
ENST00000372530
|
Expression for ABCC10
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| ABCC10 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for ABCC10
1 / 2 / 3 7 probe-sets matching ABCC10 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: --
SOURCE GeneReport for Unigene cluster: Hs.55879
Expression variation in blood from EXPOLDB for ABCC10 UniProtKB/Swiss-Prot: MRP7_HUMAN, Q5T3U5Tissue specificity: Isoform 1 is specifically expressed in spleen. Isoform 2 is more widely expressed |
Orthologs for ABCC10
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for ABCC10 gene from 5/12 species (see all 12
)
| Organism |
Gene |
Locus |
Description |
Human Similarity |
NCBI accessions |
dog (Canis familiaris) |
ABCC101 |
-- |
ATP-binding cassette, sub-family C (CFTR/MRP), member more |
88.56(n) 89.9(a) |
481813 XM_538934.2 XP_538934.2 |
chimpanzee (Pan troglodytes) |
ABCC101 |
-- |
ATP-binding cassette, sub-family C (CFTR/MRP), member more |
99.51(n) 99.31(a) |
462717 XM_518494.2 XP_518494.2 |
cow (Bos taurus) |
ABCC101 |
-- |
ATP-binding cassette, sub-family C (CFTR/MRP), member more |
88.9(n) 90.04(a) |
508399 XM_585169.3 XP_585169.3 |
rat (Rattus norvegicus) |
Abcc101 |
-- |
ATP-binding cassette, sub-family C (CFTR/MRP), member more |
85.31(n) 85.75(a) |
316231 XM_236930.4 XP_236930.4 |
mouse (Mus musculus) |
Abcc101, 5 |
175
|
ATP-binding cassette, sub-family C (CFTR/MRP), member more1, 5 |
84.99(n)1 84.85(a)1 |
2248141 NM_170680.21 NP_733780.11 AF4066425 AF4171215 (see all 16) |
About this table Species with no ortholog for ABCC10
ENSEMBL Gene Tree for ABCC10 | Paralogs for ABCC10(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for ABCC10 gene
- CFTR2 ABCC82 ABCC92
|
SNPs/Variants for ABCC10(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for ABCC10 (up to first 250kb)
|
Disorders & Mutations for ABCC10
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 612509
Human Genome Epidemiology Navigator: ABCC10 (1 document)
|
Medical News for ABCC10(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for ABCC10 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/20 PubMed articles for ABCC10 gene (see all 20
):- Genomic structure, gene expression, and promoter analysis of human multidrug resistance-associated protein 7. (PubMed id 12566991)1, 3, 4 Kao H.-H.... Huang J.-D. (2003)
- Analysis of the drug resistance profile of multidrug resistance protein 7 (ABCC10): resistance to docetaxel. (PubMed id 15256465)1, 3, 4 Hopper-Borge E.... Kruh G.D. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)3, 4 Ota T....Sugano S. (2004)
- Characterization of the transport properties of human multidrug resistance protein 7 (MRP7, ABCC10). (PubMed id 12527806)3, 4 Chen Z.-S....Kruh G.D. (2003)
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)3, 4 Mungall A.J.... Beck S. (2003)
- Characterization of the human ABC superfamily: isolation and mapping of 21 new genes using the expressed sequence tags database. (PubMed id 8894702)2, 3 Allikmets R....Dean M. (1996)
- Analysis of the structure and expression pattern of MRP7 (ABCC10), a new member of the MRP subfamily. (PubMed id 11146224)1, 3 Hopper E....Kruh G.D. (2001)
- Multidrug resistance-associated protein 7 expression is involved in cross-resistance to docetaxel in salivary gland adenocarcinoma cell lines. (PubMed id 17203221)1, 3 Naramoto H....Furusawa K. (2007)
- Cutting edge: HLA-E binds a peptide derived from the ATP-binding cassette transporter multidrug resistance-associated protein 7 and inhibits NK cell-mediated lysis. (PubMed id 16034073)1, 3 Wooden S.L....Soloski M.J. (2005)
- ABCC10/MRP7 is associated with vinorelbine resistance in non-small cell lung cancer. (PubMed id 19082471)3 Bessho Y....Ueda R. (2009)
|
Search for ABCC10
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing ABCC10
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing ABCC10
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ABCC10(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for ABCC10(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for ABCC10:

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Incremental update: 13 Oct 2009
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