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ABCC1 Gene

protein-coding   GIFtS: 71
GCID: GC16P016043

ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 1

(Previous name: multidrug resistance associated protein 1)
(Previous symbols: MRP, MRP1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 11 2     ATP-Binding Cassette Transporter Variant ABCC1delta-Ex132
MRP1 2 3 5     ATP-Binding Cassette Transporter Variant ABCC1delta-Ex13&142
MRP11 2 3 5     ATP-Binding Cassette Transporter Variant ABCC1delta-Ex252
Leukotriene C(4) Transporter2 3     ATP-Binding Cassette Transporter Variant ABCC1delta-Ex25&262
LTC4 Transporter2 3     Multidrug Resistance-Associated Protein 12
Multidrug Resistance Associated Protein 11     ATP-Binding Cassette Sub-Family C Member 13
ABC292     EC 3.6.38
ABCC2     EC 3.6.3.448
GS-X2     

External Ids:    HGNC: 511   Entrez Gene: 43632   Ensembl: ENSG000001032227   OMIM: 1583435   UniProtKB: P335273   

Export aliases for ABCC1 gene to outside databases

Previous GC identifers: GC16P015870 GC16P015325 GC16P016009 GC16P015950 GC16P015437


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ABCC1 Gene:
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC
proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven
distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP
subfamily which is involved in multi-drug resistance. This protein functions as a multispecific organic anion
transporter, with oxidized glutatione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This
protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Alternatively
spliced variants of this gene have been described but their full-length nature is unknown. (provided by RefSeq,
Apr 2012)

GeneCards Summary for ABCC1 Gene:
ABCC1 (ATP-binding cassette, sub-family C (CFTR/MRP), member 1) is a protein-coding gene. Diseases associated with ABCC1 include intraocular retinoblastoma, and dubin-johnson syndrome. GO annotations related to this gene include ATPase activity, coupled to transmembrane movement of substances and transporter activity. An important paralog of this gene is ABCC4.

UniProtKB/Swiss-Prot: MRP1_HUMAN, P33527
Function: Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of
glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral
drugs and other xenobiotics. Confers resistance to anticancer drugs. Hydrolyzes ATP with low efficiency

summary for ABCC1 Gene:
ABCC1 (also known as multidrug resistance-associated protein 1, or MRP1), is a member of the human ABC
transporter family that is involved in multidrug resistance.

Gene Wiki entry for ABCC1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000016.10  NT_010393.17  NC_018927.2  NT_187607.1  
Regulatory elements:
   Regulatory transcription factor binding sites in the ABCC1 gene promoter:
         c-Fos   AP-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidABCC1 promoter sequence
   Search Chromatin IP Primers for ABCC1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ABCC1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.1   Ensembl cytogenetic band:  16p13.11   HGNC cytogenetic band: 16p13.1

ABCC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ABCC1 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P016043:  view genomic region     (about GC identifiers)

Start:
16,043,434 bp from pter      End:
16,236,931 bp from pter
Size:
193,498 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MRP1_HUMAN, P33527 (See protein sequence)
Recommended Name: Multidrug resistance-associated protein 1  
Size: 1531 amino acids; 171591 Da
1 PDB 3D structure from and Proteopedia for ABCC1:
2CBZ (3D)    
Secondary accessions: A3RJX2 C9JPJ4 O14819 O43333 P78419 Q59GI9 Q9UQ97 Q9UQ99 Q9UQA0
Alternative splicing: 9 isoforms:  P33527-1   P33527-2   P33527-3   P33527-4   P33527-5   P33527-6   P33527-7   P33527-8   
P33527-9   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ABCC1: NX_P33527

Explore proteomics data for ABCC1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys303, Lys307, Lys315, Lys488, Lys503, Lys513, Lys636, Lys773, Lys814, Lys891,
                                 Lys908, Lys1322, Lys1333, Lys1360, Lys1369, Lys1502
  • Glycosylation2 at Asn19, Asn23, Asn1006
  • Modification sites at PhosphoSitePlus
  • 2 DME Specific Peptides for ABCC1 (P33527)
     SVGQRQL  LSGGQKQRV 


    See ABCC1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004987.2  
    ENSEMBL proteins: 
     ENSP00000382342   ENSP00000461615   ENSP00000459693   ENSP00000382340   ENSP00000263019  
     ENSP00000263017   ENSP00000263014   ENSP00000263016  
    Reactome Protein details: P33527

    ABCC1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for ABCC1
    OriGene Custom MassSpec
    OriGene Custom Protein Services for ABCC1
    GenScript Custom Purified and Recombinant Proteins Services for ABCC1
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    ABCC1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of ABCC1
    R&D Systems Antibodies for ABCC1 (MRP1)
    OriGene Antibodies for ABCC1
    OriGene Custom Antibody Services for ABCC1
    Novus Biologicals ABCC1 Antibodies
    Abcam antibodies for ABCC1
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for ABCC1
    Search LSBio for Antibodies for ABCC1

    ABCC1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ABCC1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ABCC1
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ABCC: ATP binding cassette transporters / subfamily C

    IUPHAR Guide to PHARMACOLOGY protein family classification: ABCC1
    ABCC subfamily

    Selected InterPro protein domains (see all 7):
     IPR003439 ABC_transporter-like
     IPR027417 P-loop_NTPase
     IPR001140 ABC_transptr_TM_dom
     IPR003593 AAA+_ATPase
     IPR011527 ABC1_TM_dom

    Graphical View of Domain Structure for InterPro Entry P33527

    ProtoNet protein and cluster: P33527

    UniProtKB/Swiss-Prot: MRP1_HUMAN, P33527
    Similarity: Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208)
    subfamily
    Similarity: Contains 2 ABC transmembrane type-1 domains
    Similarity: Contains 2 ABC transporter domains


    ABCC1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MRP1_HUMAN, P33527
    Function: Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of
    glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral
    drugs and other xenobiotics. Confers resistance to anticancer drugs. Hydrolyzes ATP with low efficiency

         Genatlas biochemistry entry for ABCC1:
    ATP binding cassettte superfamily,subfamily C (CFTR/MRP),member 1,ubiquitously expressed,with several
    alternatively spliced forms,also containing a CGG repeat in 5'utr

         Enzyme Numbers (IUBMB): EC 3.6.3.442 EC 3.6.32

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding ----
    GO:0005215transporter activity TAS1360704
    GO:0005524ATP binding IEA--
    GO:0016887ATPase activity IDA15999530
    GO:0017111nucleoside-triphosphatase activity ----
         
    ABCC1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for ABCC1:
     Decreased Salmonella enterica   Increased S DNA content 

         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Abcc1):
     hematopoietic system  homeostasis/metabolism  immune system  mortality/aging  nervous system 
     other 

    ABCC1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for ABCC1: Abcc1tm1Bor Abcc1tm1Acs

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ABCC1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ABCC1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ABCC1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ABCC1

    miRNA
    Products:
        
    miRTarBase miRNAs that target ABCC1:
    hsa-mir-339-5p (MIRT042744), hsa-let-7b-5p (MIRT032483), hsa-mir-615-3p (MIRT040354), hsa-mir-98-5p (MIRT027818), hsa-mir-134-5p (MIRT004494), hsa-mir-7-5p (MIRT003199), hsa-mir-16-5p (MIRT051224), hsa-mir-23b-3p (MIRT046316), hsa-mir-345-5p (MIRT003198), hsa-mir-125b-5p (MIRT046005), hsa-mir-9-5p (MIRT021440), hsa-mir-1 (MIRT024051)

    Block miRNA regulation of human, mouse, rat ABCC1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ABCC1 (see all 34):
    hsa-miR-330-5p hsa-miR-486-3p hsa-miR-1184 hsa-miR-133a hsa-miR-186 hsa-miR-3613-3p hsa-miR-326 hsa-miR-509-3-5p
    SwitchGear 3'UTR luciferase reporter plasmidABCC1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ABCC1
    Predesigned siRNA for gene silencing in human, mouse, rat ABCC1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ABCC1

    Clone
    Products:
         
    OriGene clones in human, mouse for ABCC1 (see all 15)
    OriGene ORF clones in mouse, rat for ABCC1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 5): ABCC1 (NM_004996)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ABCC1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ABCC1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ABCC1
    Browse ESI BIO Cell Lines and PureStem Progenitors for ABCC1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ABCC1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MRP1_HUMAN, P33527: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    golgi apparatus4
    nucleus4
    extracellular2
    cytoskeleton1
    mitochondrion1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005794Golgi apparatus ----
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane IEA--
    GO:0016020membrane TAS1360704

    ABCC1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ABCC1 About   (see all 16)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Irinotecan Pathway, Pharmacokinetics
    Irinotecan Pathway, Pharmacokinetics0.69
    Taxane Pathway, Pharmacokinetics0.30
    Irinotecan Pathway0.69
    2ABC-family proteins mediated transport
    ABC-family proteins mediated transport0.69
    ABC transporters0.69
    3Defective BTD causes biotidinase deficiency
    Defective BTD causes biotidinase deficiency1.00
    Metabolism of vitamins and cofactors1.00
    Defective AMN causes hereditary megaloblastic anemia 11.00
    Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC1.00
    Defective MMAA causes methylmalonic aciduria type cblA1.00
    Defective MUT causes methylmalonic aciduria mut type1.00
    Defective CD320 causes methylmalonic aciduria1.00
    Defects in cobalamin (B12) metabolism1.00
    4Methotrexate Pathway, Pharmacokinetics
    Methotrexate Pathway (Brain Cell), Pharmacokinetics0.43
    Methotrexate Pathway, Pharmacokinetics0.43
    5Doxorubicin Pathway, Pharmacokinetics
    Doxorubicin Pathway, Pharmacokinetics0.43
    Doxorubicin Pathway (Cancer Cell), Pharmacodynamics0.43

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 BioSystems Pathways for ABCC1
        Irinotecan Pathway
    S1P1 pathway
    Sphingosine 1-phosphate (S1P) pathway

    3 Reactome Pathways for ABCC1
        ABC-family proteins mediated transport
    Synthesis of Leukotrienes (LT) and Eoxins (EX)
    Cobalamin (Cbl, vitamin B12) transport and metabolism

    Selected PharmGKB Pathways for ABCC1 (see all 10)
        Acetaminophen Pathway, Pharmacokinetics
    Doxorubicin Pathway (Cancer Cell), Pharmacodynamics
    Doxorubicin Pathway, Pharmacokinetics
    Etoposide Pathway, Pharmacokinetics/Pharmacodynamics
    Irinotecan Pathway, Pharmacokinetics

    3 Kegg Pathways  (Kegg details for ABCC1):
        ABC transporters
    Vitamin digestion and absorption
    MicroRNAs in cancer


    ABCC1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ABCC1: 
              Cancer Drug Targets in human mouse rat
              Drug Transporters in human mouse rat
              Cancer Drug Resistance in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat
              Drug Metabolism in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for ABCC1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ABCC1 (P335273 ENSP000003823424) via UniProtKB, MINT, STRING, and/or I2D (see all 40)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RHOAP615863, ENSP000004001754I2D: score=1 STRING: ENSP00000400175
    UNC93B1Q9H1C43, ENSP000002274714I2D: score=1 STRING: ENSP00000227471
    TMEM173Q86WV63, ENSP000003312884I2D: score=1 STRING: ENSP00000331288
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    GMPPBQ9Y5P63, ENSP000003090924I2D: score=1 STRING: ENSP00000309092
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006200ATP catabolic process IDA15999530
    GO:0006691leukotriene metabolic process TAS--
    GO:0006766vitamin metabolic process TAS--
    GO:0006767water-soluble vitamin metabolic process TAS--
    GO:0006810transport TAS1360704

    ABCC1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for ABCC1
      Browse compounds at ApexBio 

    Compounds for ABCC1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    PSC 833Inhibitor of P-gp-mediated MDR[121584-18-7]
    XR 9051 HClPotent modulator of P-gp-mediated MDR[180422-22-4]
    Ko 143Potent and selective BCRP inhibitor[461054-93-3]
    ProbenecidMRP inhibitor[57-66-9]
    Elacridar hydrochlorideP-gp inhibitor[143851-98-3]

    1 HMDB Compound for ABCC1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Leukotriene C4(R-(R*,S*-(E,E,Z,Z)))-N-(S-(1-(4-carboxy-1-hydroxybutyl)-2,4,6,9-pentadecatetraenyl)-N-L-gamma-glutamyl-L-cysteinyl)-Glycine (see all 12)72025-60-6--

    Selected DrugBank Compounds for ABCC1 (see all 54)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Daunorubicin-- 20830-81-3transportersubstrate inhibitor9188796 10729360 8621644 19944162 7945406 10188979 9281595 9647783 12657726 10708754 10917554 16830181 12867490 10917553
    Probenecid-- 57-66-9transporterinhibitor14511674 10500791 10727523 11118294 11880368 10329417 10419897 10917554 10363967
    DoxorubicinAdria (see all 4)23214-92-8transportersubstrate inhibitor19725578 8621644 19390592 19255759 9281595 12657726 12867490 12765240
    SulfinpyrazoneDiphenylpyrazone (see all 6)57-96-5targetinhibitor10727523 11752352 15044619 9885294 10917554 9685354
    transporterinhibitor10727523 11752352 15044619 9885294 10917554 9685354 10917554
    EtoposideEPEG (see all 4)33419-42-0transportersubstrate inhibitor11901101 9188796 19725578 9281595 12657726 12867490
    Vincristine22-Oxovincaleukoblastine (see all 12)57-22-7transportersubstrate inhibitor8621644 10188979 9281595 12657726 9058594 12867490
    IndomethacinIMN (see all 9)53-86-1transporterinhibitor12835412 14511674 16460798 11880368 10917554
    Genistein4',5, 7-Trihydroxyisoflavone (see all 4)446-72-0transporterinhibitor8980395 14511674 12532374 12373300
    Glutathione5-L-Glutamyl-L-cysteinylglycine (see all 5)70-18-8transportersubstrate inhibitor8640791 9188796 16539673 10917554
    Vinblastine-- 865-21-4transportersubstrate inhibitor inducer11834888 8621644 11323161 16458542

    Selected Novoseek inferred chemical compound relationships for ABCC1 gene (see all 131)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mk 571 94.1 88 15120939 (2), 17008412 (2), 7887949 (2), 10947971 (2) (see all 60)
    (glc)4 90.6 66 10427142 (3), 11810759 (3), 10408915 (2), 11159731 (2) (see all 33)
    estradiol-17beta-glucuronide 89.3 32 12388549 (2), 9281595 (2), 11278596 (1), 11278867 (1) (see all 22)
    daunorubicin 87.1 160 8616077 (4), 15176077 (4), 17204174 (4), 9443942 (3) (see all 70)
    vincristine 85.9 195 15896345 (7), 7923205 (5), 8937472 (4), 9664131 (4) (see all 99)
    doxorubicin 85.5 244 15880572 (9), 7923205 (3), 12964004 (3), 20190417 (3) (see all 99)
    probenecid 85.1 129 11322768 (5), 12218384 (3), 19454316 (2), 10999764 (2) (see all 74)
    rhodamine 123 84.8 62 10955805 (2), 9713968 (2), 11288109 (2), 15120939 (2) (see all 33)
    sb 30 83.3 9 11159731 (2), 10329417 (2), 10427142 (2), 11331074 (1) (see all 6)
    psc-833 82.1 15 10955805 (2), 11189941 (2), 9375571 (1), 17855498 (1) (see all 12)

    3 PharmGKB related drug/compound annotations for ABCC1 gene    About this table
    Drug/compound PharmGKB Annotation
    doxorubicinCA  
    methotrexateCA  
    montelukastCA  



    ABCC1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

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    REFSEQ mRNAs for ABCC1 gene (7 alternative transcripts): 
    NM_004996.3  NM_019862.2  NM_019898.2  NM_019899.2  NM_019900.2  NM_019901.1  NM_019902.1  

    Unigene Cluster for ABCC1:

    ATP-binding cassette, sub-family C (CFTR/MRP), member 1
    Hs.391464  [show with all ESTs]
    Unigene Representative Sequence: NM_004996
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000399410 ENST00000572882(uc021tdq.1 uc021tdr.1 uc021tds.1 uc021tdt.1)
    ENST00000574224(uc010bvn.3) ENST00000575422 ENST00000576557 ENST00000572053
    ENST00000574761 ENST00000399408(uc010bvi.3 uc002del.4) ENST00000346370(uc010bvk.3)
    ENST00000351154(uc010bvj.3) ENST00000345148(uc010bvl.3) ENST00000349029(uc010bvm.3)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ABCC1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ABCC1 (see all 34):
    hsa-miR-330-5p hsa-miR-486-3p hsa-miR-1184 hsa-miR-133a hsa-miR-186 hsa-miR-3613-3p hsa-miR-326 hsa-miR-509-3-5p
    SwitchGear 3'UTR luciferase reporter plasmidABCC1 3' UTR sequence
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    GenScript: all cDNA clones in your preferred vector (see all 5): ABCC1 (NM_004996)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ABCC1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ABCC1
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    Additional mRNA sequence: 

    AB209120.1 AJ003198.1 AK097871.1 AK311015.1 BC001636.1 BX648866.1 CR749835.1 HQ917064.1 
    HQ917065.1 HQ917066.1 HQ917067.1 L05628.1 X78338.1 

    Selected DOTS entries (see all 25):

    DT.100817334  DT.101983347  DT.97799615  DT.444581  DT.102841888  DT.102841978  DT.120692263  DT.120692138 
    DT.102841295  DT.100817332  DT.120692056  DT.92040146  DT.99929967  DT.99930223  DT.100863932  DT.120691986 
    DT.40131770  DT.91757212  DT.92015144  DT.92050254  DT.95074693  DT.95257421  DT.95294943  DT.91925284 

    Selected AceView cDNA sequences (see all 200):

    AI798255 AI648621 BG698823 CF272373 BQ434553 BM799798 BM193098 BU176528 
    R63723 BX280480 BM738288 AA424804 AL043477 Z39651 AW270744 BM678021 
    BC001636 AI696452 AA412168 CA488065 BM145377 AL706199 AI224066 NM_004996 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for ABCC1    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21 ^ 22 ^
    SP1:                                                                                      -                                         -                 -         
    SP2:                                                                                      -                                                           -         
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            

    ExUns: 23 ^ 24a · 24b ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32a · 32b
    SP1:                                                                        
    SP2:                                                                        
    SP3:                                                                        
    SP4:                                                                        


    ECgene alternative splicing isoforms for ABCC1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    ABCC1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTTATGAAGC
    ABCC1 Expression
    About this image


    ABCC1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Mature Choroid Plexus Cells Choroid Plexus
             Mature brain microvascular endothelial cells
     
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             Endothelial Cells Blood Brain Barrier
             Mature brain microvascular endothelial cells
     
     Epithelial Cells
             Mature Choroid Plexus Cells Choroid Plexus
     
     Blood (Cardiovascular System)
             Definitive Hematopoietic Stem Cells Definitive Yolk Sac
     
     Yolk Sac (Extraembryonic Tissues)
             Definitive Hematopoietic Stem Cells Definitive Yolk Sac
    ABCC1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ABCC1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.391464

    UniProtKB/Swiss-Prot: MRP1_HUMAN, P33527
    Tissue specificity: Lung, testis and peripheral blood mononuclear cells

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ABCC1: 
              Cancer Drug Targets in human mouse rat
              Drug Transporters in human mouse rat
              Cancer Drug Resistance in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat
              Drug Metabolism in human mouse rat

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ABCC1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ABCC1 gene from Selected species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Abcc11 , 5 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 less1, 5 83.84(n)1
    88.47(a)1
      16 (9.75 cM)5
    172501  NM_008576.31  NP_032602.11 
     143615585 
    chicken
    (Gallus gallus)
    Aves ABCC11 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 less 71.44(n)
    78.32(a)
      395416  NM_001012522.1  NP_001012540.1 
    lizard
    (Anolis carolinensis)
    Reptilia ABCC16
    ATP-binding cassette, sub-family C (CFTR/MRP), mem...
    72(a)
    1 ↔ 1
    GL344209.1(2379-66795)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.37482 Transcribed sequence with moderate similarity to protein spP33527 (H.sapiens) MRP1_HUMAN Multidrug resistance-associated protein 1 less 74.52(n)    AL852319.2 
    zebrafish
    (Danio rerio)
    Actinopterygii abcc11 ATP-binding cassette, sub-family C, member 1 67.5(n)
    71.17(a)
      100002010  XM_001341859.4  XP_001341895.3 
    worm
    (Caenorhabditis elegans)
    Secernentea mrp-21 , 3 ATP-binding transport family3
    mrp-21
    46(a)
    (best of 4)3
    51.46(n)1
    49.25(a)1
      X(599137-607953)3
    1804081  NM_075720.51  NP_508121.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes YCF16
    Vacuolar glutathione S-conjugate transporter; memb...
    40(a)
    1 → many
    IV(723004-727551) YDR135C
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons MRP51 MRP5 44.74(n)
    37.9(a)
      839277  NM_100293.2  NP_171908.1 
    rice
    (Oryza sativa)
    Liliopsida Os.56312 Transcribed sequence with moderate similarity to protein refNP_181013.1 (A.thaliana) ABC transporter (AtMRP2) [Arabidopsis thaliana] less 68.51(n)    CF196883.1 


    ENSEMBL Gene Tree for ABCC1 (if available)
    TreeFam Gene Tree for ABCC1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ABCC1 gene
    ABCC42  ABCC122  ABCC82  ABCC52  ABCC62  ABCC32  ABCC22  ABCC92  
    ABCC112  
    Selected SIMAP similar genes for ABCC1 using alignment to 7 protein entries:     MRP1_HUMAN (see all proteins) (see all similar genes):
    DKFZp781G125    MRP    TAP1    MRP3    ABCB4    DKFZp434I2115
    ABCC3    ABCC6    MOAT-B    NG-TRA    ABCC2    CFTR
    ABCC10    ara    ABCC4    ABCC13    ABCC8    ABCC9

    ABCC1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ABCC1 (see all 5181)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs784062661,2
    C--16043116(+) CAGGC-/AGGT  
            
    AGGGG
    1 -- us2k10--------
    rs41483321,2
    C--16048426(+) ACTCA-/GGGGTT 1 -- int12Minor allele frequency- G:0.25NA CSA 4
    rs98890881,2
    C,F--16056715(+) cctggC/Tccctc 1 -- int13Minor allele frequency- T:0.12NA WA 122
    rs288448821,2
    C,F--16056902(+) GATACG/AATGGG 1 -- int11Minor allele frequency- A:0.50WA 2
    rs614193121,2
    C--16057403(+) TGAAA-/ATCTAG 1 -- int11Minor allele frequency- A:0.50CSA 2
    rs774255081,2
    C,F--16057535(+) TGGCTC/TCTCTT 1 -- int11Minor allele frequency- T:0.03WA 118
    rs680005571,2
    C--16059323(+) TTTGT-/GTTTTTA 1 -- int10--------
    rs1114525531,2
    F--16059466(+) TTTAAC/TTTTTT 1 -- int12Minor allele frequency- T:0.10CSA WA 120
    rs614999521,2
    C--16060126(+) AGCTG-/GGCGTG 1 -- int10--------
    rs677019301,2
    C--16060267(+) AAAAAA/-AAAAA 1 -- int11Minor allele frequency- -:0.00NA 2

    HapMap Linkage Disequilibrium report for ABCC1 (16043434 - 16236931 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for ABCC1 (see all 38):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2714025CNV Deletion23290073
    esv2661498CNV Deletion23128226
    esv2714015CNV Deletion23290073
    esv2714022CNV Deletion23290073
    esv2399145CNV Deletion18987734
    nsv435664CNV Deletion17901297
    esv2714027CNV Deletion23290073
    esv2714026CNV Deletion23290073
    esv2667672CNV Deletion23128226
    esv2674034CNV Deletion23128226

    Human Gene Mutation Database (HGMD): ABCC1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ABCC1
    DNA2.0 Custom Variant and Variant Library Synthesis for ABCC1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 158343    OMIM disorders: --

    Selected diseases for ABCC1 (see all 125):    
    About MalaCards
    intraocular retinoblastoma    dubin-johnson syndrome    cholangiolocellular carcinoma    pseudoxanthoma elasticum
    microsporidiosis    intraocular lymphoma    cholestasis    core binding factor acute myeloid leukemia
    kernicterus    ewing's family of tumors    brain glioma    epithelioid sarcoma
    intrahepatic cholestasis of pregnancy    desmoplastic small round cell tumor    intrahepatic cholestasis    somatostatin analog
    acute liver failure    status epilepticus    retinoblastoma    lymphoblastic leukemia

    3 diseases from the University of Copenhagen DISEASES database for ABCC1:
    Dubin-Johnson syndrome     Pseudoxanthoma elasticum     Cancer

    ABCC1 for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for ABCC1 gene (see all 88)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    dubin-johnson syndrome 71.7 8 8621134 (4), 10695015 (1), 8869738 (1)
    breast cancer 65 273 15517899 (4), 10697508 (4), 14659356 (4), 15718312 (4) (see all 99)
    cancer 64.7 262 9762421 (5), 8881943 (5), 9815925 (4), 11245443 (4) (see all 99)
    leukemia 63.6 108 8833393 (4), 7803281 (3), 10901300 (3), 9603996 (3) (see all 69)
    tumors 63.1 478 15269137 (6), 17359940 (5), 9182980 (5), 15838832 (5) (see all 99)
    colchicine resistance 56.5 1 9649117 (1)
    cancer lung 55 119 11585860 (5), 8647646 (5), 11410522 (5), 11776768 (5) (see all 62)
    pseudoxanthoma elasticum 52.4 6 11139250 (2), 11439001 (1), 12414644 (1), 16006996 (1)
    small cell lung cancer 50.9 34 9751266 (2), 16883578 (2), 15880572 (2), 8185674 (1) (see all 24)
    secondary aml 50.4 3 8618469 (1), 11167822 (1), 18418409 (1)

    Genetic Association Database (GAD): ABCC1
    Human Genome Epidemiology (HuGE) Navigator: ABCC1 (39 documents)

    Export disorders for ABCC1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ABCC1 gene, integrated from 10 sources (see all 1738):
    (articles sorted by number of sources associating them with ABCC1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Multidrug resistance-associated protein: sequence correction. (PubMed id 8098549)1, 2, 3 Cole S.P.C. and Deeley R.G. (Science 1993)
    2. Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line. (PubMed id 1360704)1, 2, 3 Cole S.P.C.... Deeley R.G. (Science 1992)
    3. Mutational analysis of ionizable residues proximal to the cytoplasmic interface of membrane spanning domain 3 of the multidrug resistance protein, MRP1 (ABCC1): glutamate 1204 is important for both the expression and catalytic activity of the transporter. (PubMed id 15208328)1, 2, 9 Situ D.... Cole S.P.C. (J. Biol. Chem. 2004)
    4. Membrane topology of the multidrug resistance protein (MRP). A study of glycosylation-site mutants reveals an extracytosolic NH2 terminus. (PubMed id 9295302)1, 2, 9 Hipfner D.R.... Cole S.P.C. (J. Biol. Chem. 1997)
    5. Identification of an amino acid residue in multidrug resistance protein 1 critical for conferring resistance to anthracyclines. (PubMed id 11278596)1, 2, 9 Zhang D.-W.... Deeley R.G. (J. Biol. Chem. 2001)
    6. ABCB1 and ABCC1 expression in peripheral mononuclear cells is influenced by gene polymorphisms and atorvastatin treatment. (PubMed id 18851956)1, 4, 9 Rebecchi I.M....Hirata R.D. (Biochem. Pharmacol. 2009)
    7. Influence of ABCB1, ABCC1, ABCC2, and ABCG2 haplotypes on the cellular exposure of nelfinavir in vivo. (PubMed id 16041239)1, 4, 9 Colombo S....Telenti A. (Pharmacogenet. Genomics 2005)
    8. Genetic susceptibility of lung cancer associated with common variants in the 3' untranslated regions of the adenosine triphosphate-binding cassette B1 (ABCB1) and ABCC1 candidate transporter genes for carcinogen export. (PubMed id 19107762)1, 4, 9 Wang H....Lu D. (Cancer 2009)
    9. MRP1 polymorphisms (T2684C, C2007T, C2012T, and C2665T) are not associated with multidrug resistance in leukemic patients. (PubMed id 19065772)1, 4, 9 Mahjoubi F....Moshyri F. (Genet. Mol. Res. 2008)
    10. NAD(P)H oxidase and multidrug resistance protein genetic polymorphisms are associated with doxorubicin-induced cardiotoxicity. (PubMed id 16330681)1, 4, 9 Wojnowski L....Hasenfuss G. (Circulation 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4363 HGNC: 51 AceView: ABCC1 Ensembl:ENSG00000103222 euGenes: HUgn4363
    ECgene: ABCC1 Kegg: 4363 H-InvDB: ABCC1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ABCC1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ABCC1 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/abcc1/
    ABCMdbhttp://abcmutations.hegelab.org/proteinDetails?uniprot_id=P33527

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ABCC1 gene:
    Search GeneIP for patents involving ABCC1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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