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ABCC1 Gene

protein-coding   GIFtS: 71

GC16P015950
ATP-binding cassette, sub-family C (CFTR/MRP), member 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: MRP, MRP1)
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases
ABC29 2
ABCC 2
DKFZp686N04233 2
DKFZp781G125 2
GS-X 1, 2
MRP 2, 3, 5
MRP1 2, 3, 5
OTTHUMP00000045904 2
Descriptions
ATP-binding cassette sub-family C member 1 3
ATP-binding cassette, sub-family C (CFTR/MRP), member 1 2
ATP-binding cassette, sub-family C, member 1 2
LTC4 transporter 2, 3
Leukotriene C(4) transporter 2, 3
multidrug resistance protein 2
multiple drug resistance protein 1 2
multiple drug resistance-associated protein 2
External Ids
HGNC: 511
Entrez Gene: 43632
UniProtKB: P335273
Ensembl: ENSG000001032227
Search outside databases for aliases for ABCC1 gene

Previous GC identifers: GC16P015870 GC16P015325 GC16P016009

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for ABCC1:
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC)
transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes.
ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20,
White). This full transporter is a member of the MRP subfamily which is involved in multi-drug
resistance. This protein functions as a multispecific organic anion transporter, with oxidized
glutatione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also
transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Alternative
splicing by exon deletion results in several splice variants but maintains the original open
reading frame in all forms. [provided by RefSeq]

UniProtKB/Swiss-Prot: MRP1_HUMAN, P33527
Function: Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent
transport of glutathione and glutathione conjugates, leukotriene C4,
estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers
resistance to anticancer drugs. Hydrolyzes ATP with low efficiency

Gene Wiki entry for ABCC1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the ABCC1 gene  

Entrez Gene cytogenetic band: 16p13.1   Ensembl cytogenetic band:  16p13.11   HGNC cytogenetic band: 16p13.1

ABCC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P015950:     (about GC identifiers)

Start:
15,950,935 bp from pter
End:
16,144,432 bp from pter
Size:
193,498 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000016.8  NT_010393.15  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: MRP1_HUMAN, P33527 (See protein sequence)
Recommended Name: Multidrug resistance-associated protein 1  
Size: 1531 amino acids; 171561 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
PDB structures from and Proteopedia :
2CBZ (3D)    
Secondary accessions: A3RJX2 O14819 O43333 P78419 Q59GI9 Q9UQ97 Q9UQ99 Q9UQA0
Alternative splicing: 9 isoforms:  P33527-1   P33527-2   P33527-3   P33527-4   P33527-5   P33527-6   P33527-7   P33527-8   
P33527-9   (Additional isoforms seem to exist. Experimental confirmation may be lacking for some isoforms)

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins (5 alternative transcripts): 
    NP_004987.2  NP_063915.2  NP_063953.2  NP_063954.2  NP_063955.2  


    ENSEMBL proteins: 
    ENSP00000382342 ENSP00000382340 ENSP00000263018 ENSP00000263015 ENSP00000263019 ENSP00000263017 
    ENSP00000263014 ENSP00000263016 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (MRP1)
    Human Recombinant Proteins from Abnova (ABCC1)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    3 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005624 membrane fraction TAS1360704
    GO:0005887 integral to plasma membrane TAS1360704
    GO:0016020 membrane IEA--
    About this table

    Antibodies for ABCC1: 
    Invitrogen Antibodies for ABCC1
    Millipore Mono- and Polyclonal Antibodies for the study of ABCC1
    Sigma-Aldrich Antibody Arrays and Antibodies for ABCC1
    R&D Systems Antibodies for ABCC1 (MRP1)
    Antibodies from Abcam (MRP1), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (ABCC1)
    Novus Biologicals Antibody for ABCC1

    Assays for ABCC1: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    5/6 InterPro domains/families (see all 6 ):
     IPR003593 ATPase_AAA+_core
     IPR003439 ABC_transporter-like
     IPR017940 ABC_transporter_type1
     IPR005292 Multidrug-R_assoc_MRP
     IPR001140 ABC_TM_transpt


       GeneDecks  ABCC1 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry P33527

    ProtoNet protein and cluster: P33527

    UniProtKB/Swiss-Prot: MRP1_HUMAN, P33527
    Similarity: Belongs to the ABC transporter family. Conjugate transporter (TC 3.A.1.208) subfamily
    Similarity: Contains 2 ABC transmembrane type-1 domains
    Similarity: Contains 2 ABC transporter domains

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (ABCC1)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (ABCC1)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 7): NM_004996

                  Applied Biosystems Silencer® siRNAs for ABCC1

                  Sigma-Aldrich siRNA and siRNA Panels for ABCC1  
                         Sigma-Aldrich shRNA for ABCC1  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Browse Clone Ranger at Invitrogen for clones
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 5): NM_004996
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 5): NM_004996
                                     untagged cDNA clones in CMV expression vector (see all 7): NM_004996 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_004996

    UniProtKB/Swiss-Prot: MRP1_HUMAN, P33527
    Function: Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent
    transport of glutathione and glutathione conjugates, leukotriene C4,
    estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers
    resistance to anticancer drugs. Hydrolyzes ATP with low efficiency

    Genatlas biochemistry entry for ABCC1:
    ATP binding cassettte superfamily,subfamily C (CFTR/MRP),member 1,ubiquitously expressed,with
    several alternatively spliced forms,also containing a CGG repeat in 5'utr

    5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Abcc1):

    hematopoietic systemhomeostasis/metabolismimmune systemlife span-post-weaning/aging

    5 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166 nucleotide binding IEA--
    GO:0005215 transporter activity TAS1360704
    GO:0005524 ATP binding TAS1360704
    GO:0016887 ATPase activity IDA15999530
    GO:0042626 ATPase activity, coupled to transmembrane movement of substances TAS1360704
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


    3 Sigma-Aldrich "Your Favorite Gene" Pathways for  ABCC1  (Your Favorite Gene powered by Ingenuity) 
     Hepatic Cholestasis
     Purine Metabolism
     NRF2-mediated Oxidative Stress Response

       GeneDecks  ABCC1 for the pathways selected above  
    About GeneDecksing

    1 Kegg Pathway  (Kegg details for ABCC1):
     hsa02010 ABC transporters

       GeneDecks  ABCC1 for the pathways selected above  
    About GeneDecksing
     Gene Network CentralTM Interacting Genes and Proteins Network for  ABCC1 

    2 Gene Ontology (GO) biological process terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810 transport TAS1360704
    GO:0042493 response to drug TAS1360704
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Sigma-Aldrich Small Molecules for ABCC1:
    Inhibitor

    Compounds for ABCC1 available from Tocris Bioscience
    CompoundAction CAS number
    MK 571Potent CysLT1 (LTD4) inverse agonist. Also MRP inhibitor[115104-28-4]
    About this table


    10/31 Novoseek chemical compound relationships for ABCC1 gene (see all 31 )
    Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    (glc)4 90.94 66 10427142 (3), 11810759 (3), 10408915 (2), 11159731 (2) (see all 33)
    estradiol-17beta-glucuronide 89.69 32 12388549 (2), 9281595 (2), 11278596 (1), 11278867 (1) (see all 22)
    rhodamine 123 83.98 60 10955805 (2), 9713968 (2), 11288109 (2), 15120939 (2) (see all 31)
    sb 30 83.71 9 11159731 (2), 10329417 (2), 10427142 (2), 11331074 (1) (see all 6)
    biricodar 82.09 9 11408511 (2), 9738565 (2), 12217752 (1), 12721757 (1) (see all 5)
    gf 120918 79.11 12 10917553 (2), 11189941 (2), 15359574 (1), 11118294 (1) (see all 6)
    s-(2,4-dinitrophenyl)glutathione 77.96 5 10077229 (1), 9762421 (1), 12950253 (1), 8692921 (1) (see all 5)
    etoposide glucuronide 76.44 1 8869738 (1)
    ly335979 76.32 2 12455064 (1), 10411602 (1)
    ltc4 74.82 81 8621643 (5), 12682044 (4), 11898391 (3), 8910374 (3) (see all 30)
    About this table

    10/16 PharmGKB drug compound relationships for ABCC1 gene (see all 16 )
    Drug compound PharmGKB Relations PubMed IDs for articles supporting these relationships
    chlorambucilFA  9685354
    colchicineFA  7954421 7916458
    daunorubicinFA  7954421 7916458
    doxorubicinFA  7954421 8275468 7916458 9685354
    epirubicinFA  7954421
    estrogensPK  12042670
    etoposideFA  7954421 8640791 7915193 7809167 9685354 8275468 7916458
    folic acidFA  11585759 12486126
    irinotecanFA  GN  10220571
    leucovorinFA  11585759 12486126
    About this table


    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (ABCC1)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (ABCC1)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 7): NM_004996

                  Sigma-Aldrich siRNA and siRNA Panels for ABCC1  
                         Sigma-Aldrich shRNA for ABCC1  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_004996  NM_019862  NM_019898  NM_019899  NM_019900  

    REFSEQ mRNAs for ABCC1 gene (5 alternative transcripts): 

    NM_004996.3   NM_019862.2   NM_019898.2   NM_019899.2   NM_019900.2   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_004996  NM_019862  NM_019898  NM_019899  NM_019900  

                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 5): NM_004996
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 5): NM_004996
                                     untagged cDNA clones in CMV expression vector (see all 7): NM_004996 

    Additional cDNA sequence: 

    AB209120.1 AJ003198.1 AK097871.1 AK311015.1 BC001636.1 BX648866.1 CR749835.1 L05628.1 
    X78338.1 

    24/26 DOTS entries (see all 26 ):

    DT.100817334  DT.101983347  DT.444581  DT.97799615  DT.102841888  DT.102841978  DT.120692263  DT.102841295 
    DT.100817332  DT.120692056  DT.120692138  DT.99930223  DT.92040146  DT.99929967  DT.92015144  DT.120691986 
    DT.40131770  DT.91757212  DT.92024320  DT.92050254  DT.95074693  DT.95257421  DT.95294943  DT.100863932 

    24/200 AceView cDNA sequences (see all 200 ):

    BM799798 BM193098 R63723 BM145377 BM678021 BC001636 AI224066 AI648621 
    AW270744 CA488065 AI798255 AA424804 BU176528 BM738288 AI696452 AL706199 
    AL043477 AA412168 BX280480 BQ434553 Z39651 CF272373 BG698823 X78338 

    highest scoring ESTs for ABCC1:

    L05628 X78338 AA133518 AA306323 AA311707 AA312126 AA328314 AA399068 AA495876 AI123076 

    Unigene Cluster for ABCC1:

    ATP-binding cassette, sub-family C (CFTR/MRP), member 1
    Hs.709181  [show with all ESTs]
    Unigene Representative Sequence: NM_004996


    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for ABCC1

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21 ^ 22 ^
    SP1:                                                                                      -                                         -                 -         
    SP2:                                                                                      -                                                           -         
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            

    ExUns: 23 ^ 24a · 24b ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32a · 32b
    SP1:                                                                        
    SP2:                                                                        
    SP3:                                                                        
    SP4:                                                                        

    About this scheme

    ECgene alternative splicing isoforms for ABCC1

    8 Ensembl transcripts including schematic representations:
    ENST00000399410  ENST00000399408  ENST00000349532  ENST00000353257  ENST00000346370  ENST00000351154  
    ENST00000345148  ENST00000349029  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    ABCC1 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for ABCC1

    1 / 2 / 3

    8 probe-sets matching ABCC1 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    34017_s_at2, 3 U95-A 1 1.00 1.00 0.75 0.46 AF022853 0.20 1.00 0.72 1
    34016_s_at2, 3 U95-A 1 1.00 1.00 0.92 1.31 X78338 1.00 1.00 1.00 1

    1896_s_at2, 3 U95-A 1 1.00 1.00 0.89 1.19 L05628 1.00 1.00 1.00 1

    34384_at2, 3 U95-A 1 1.00 1.00 0.91 1.07 AF022853 0.20 1.00 0.72 1

    202805_s_at2, 3 U133-A 1 1.00 1.00 -- -- NM_004996 0.60 1.00 0.82 1

    202804_at2, 3 U133-A 1 1.00 1.00 -- -- AI539710 0.80 1.00 0.91 1

    202805_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    202804_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    GeneDecks  ABCC1 for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: GTTATGAAGC

    SOURCE GeneReport for Unigene cluster: Hs.709181

    Expression variation in blood from EXPOLDB for ABCC1

    UniProtKB/Swiss-Prot: MRP1_HUMAN, P33527
    Tissue specificity: Lung, testis and peripheral blood mononuclear cells

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for ABCC1 gene from 5/23 species (see all 23 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    ABCC11   -- ATP-binding cassette, sub-family C (CFTR/MRP), member more 88.63(n)
    91.64(a)
    403453  NM_001002971.1  NP_001002971.1 
    chimpanzee
    (Pan troglodytes)
    ABCC11   -- ATP-binding cassette, sub-family C (CFTR/MRP), member more 98.91(n)
    99.41(a)
    453952  XM_001145351.1  XP_001145351.1 
    cow
    (Bos taurus)
    ABCC11   -- ATP-binding cassette, sub-family C (CFTR/MRP), member more 88.76(n)
    90.78(a)
    281588  NM_174223.1  NP_776648.1 
    rat
    (Rattus norvegicus)
    Abcc11   -- ATP-binding cassette, sub-family C (CFTR/MRP), member more 83.03(n)
    87.58(a)
    24565  NM_022281.2  NP_071617.2 
    mouse
    (Mus musculus)
    Abcc11, 5 165
    ATP-binding cassette, sub-family C (CFTR/MRP), member more1, 5 83.84(n)1
    88.47(a)1
    172501  NM_008576.21  NP_032602.11 
     AA4735855  AF0229085  (see all 19)
    About this table        Species with no ortholog for ABCC1

    ENSEMBL Gene Tree for ABCC1
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for ABCC1 gene
    ABCC32  ABCC62  ABCC22  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/1933 NCBI SNPs in ABCC1 are shown (see all 1933 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 386)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 16 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs2120901,2
    A,C,F,H,O16143505(+) TACTGA/TTCCCA 5 -- ut3119Minor allele frequency- N:0.00EA MN EU WA NA NS 2810
    rs2120911,2
    A,C,F,H16144151(-) CCTTAA/GAGAAC 5 -- ut3117Minor allele frequency- N:0.00EA NA MN EU WA 1342
    rs5043481,2
    C,F,H,O15950675(-) CAAATC/GCTGTT 5 -- ng516Minor allele frequency- G:0.21MN EU EA WA 724
    rs37435271,2
    A,C,F,H16143182(+) TCTCCC/TCTTGG 5 -- ut3114Minor allele frequency- T:0.32MN EU EA WA NA NS 2414
    rs133374891,2
    C,F,H16116184(+) CCGCTG/CTCTGC 5 S/C mis1 ese314Minor allele frequency- C:0.03EU EA WA NS 1058
    rs41483801,2
    C,F,H16143932(+) GACACG/AAAAAG 5 -- ut3120Minor allele frequency- A:0.08NA EU EA WA NS 1590
    rs41483561,2
    C,F,H16084776(+) TCTCCG/AAGAAA 5 Q/R mis1 int120Minor allele frequency- A:0.22EU EA WA NS 1868
    rs169676321,2
    C,F,H16144284(+) AAAACG/ACATAT 5 -- ut3116Minor allele frequency- A:0.03NA EU EA WA NS 1172
    rs41483301,2
    C,F,H15949269(+) GACCCA/GGGCCA 5 -- ng5113Minor allele frequency- G:0.50EU EA WA NS 1028
    --
    rs1290811,2
    A,C,F16143440(+) ACCCCC/GACTCC 5 -- ut318Minor allele frequency- G:0.46EA MN NS 2188
    About this table

    HapMap Linkage Disequilibrium images for ABCC1 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 158343

    10/88 Novoseek disease relationships for ABCC1 gene (see all 88 )

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    dubin-johnson syndrome 72.38 8 8621134 (4), 10695015 (1), 8869738 (1)
    cancer 64.42 248 9762421 (5), 8881943 (5), 9815925 (4), 11245443 (4) (see all 99)
    leukemia 64.23 107 8833393 (4), 7803281 (3), 10901300 (3), 9603996 (3) (see all 68)
    breast cancer 63.63 234 15517899 (4), 10697508 (4), 14659356 (4), 15718312 (4) (see all 99)
    tumors 63.27 442 15269137 (6), 17359940 (5), 15838832 (5), 9182980 (5) (see all 99)
    colchicine resistance 57.18 1 9649117 (1)
    cancer lung 55.53 115 11585860 (5), 8647646 (5), 11410522 (5), 11776768 (5) (see all 60)
    secondary aml 51.98 3 8618469 (1), 11167822 (1), 18418409 (1)
    pseudoxanthoma elasticum 51.72 6 11139250 (2), 11439001 (1), 12414644 (1), 16006996 (1)
    small cell lung cancer 51.69 34 9751266 (2), 16883578 (2), 15880572 (2), 8185674 (1) (see all 24)
    About this table

    2 PharmGKB disease relationships for ABCC1 gene
    Disease PharmGKB Relations PubMed IDs for articles supporting these relationships
    LeukemiaFA  12486126
    Leukemia, Lymphocytic, Acute, L1PD  15630450
    About this table

    Human Gene Mutation Database: ABCC1
    Genetic Association Database: ABCC1
    Human Genome Epidemiology Navigator: ABCC1 (17 documents)

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/1307 PubMed articles for ABCC1 gene (see all 1307 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 4363 HGNC: 51 AceView: ABCC1 Ensembl:ENSG00000103222 euGenes: HUgn4363
    ECgene: ABCC1 H-InvDB: ABCC1
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

    NameDescription
    ATLAS Chromosomes in Cancer entry for ABCC1 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/abcc1/
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



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