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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ABCC1 Gene

protein-coding   GIFtS: 72
GCID: GC16P016043

ATP-binding cassette, sub-family C (CFTR/MRP), member 1

(Previous name: multidrug resistance associated protein 1 )
(Previous symbols: MRP, MRP1)
 Explore 142 diseases affiliated with
ABCC1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ABCC1    

Aliases
for ABCC1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 11 2     ATP-Binding Cassette Transporter Variant ABCC1delta-Ex132
MRP1 2 3 5     ATP-Binding Cassette Transporter Variant ABCC1delta-Ex13&142
MRP11 2 3 5     ATP-Binding Cassette Transporter Variant ABCC1delta-Ex252
GS-X1 2     ATP-Binding Cassette Transporter Variant ABCC1delta-Ex25&262
Leukotriene C(4) Transporter2 3     Multidrug Resistance-Associated Protein 12
LTC4 Transporter2 3     ATP-Binding Cassette Sub-Family C Member 13
Multidrug Resistance Associated Protein 11     EC 3.6.38
ABC292     EC 3.6.3.448
ABCC2     

External Ids:    HGNC: 511   Entrez Gene: 43632   Ensembl: ENSG000001032227   OMIM: 1583435   UniProtKB: P335273   

Export aliases for ABCC1 gene to outside databases

Previous GC identifers: GC16P015870 GC16P015325 GC16P016009 GC16P015950 GC16P015437


Summaries
for ABCC1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ABCC1:
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC
proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven
distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP
subfamily which is involved in multi-drug resistance. This protein functions as a multispecific organic anion
transporter, with oxidized glutatione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein
also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Alternatively spliced variants
of this gene have been described but their full-length nature is unknown. (provided by RefSeq, Apr 2012)

UniProtKB/Swiss-Prot: MRP1_HUMAN, P33527
Function: Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of
glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs
and other xenobiotics. Confers resistance to anticancer drugs. Hydrolyzes ATP with low efficiency

summary for ABCC1:
ABCC1 (also known as multidrug resistance-associated protein 1, or MRP1), is a member of the human ABC
transporter family that is involved in multidrug resistance.

Gene Wiki entry for ABCC1


Genomic Views
for ABCC1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.1  NT_010393.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ABCC1 gene promoter:
         c-Fos   AP-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ABCC1 promoter sequence
   Search SABiosciences Chromatin IP Primers for ABCC1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ABCC1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.1   Ensembl cytogenetic band:  16p13.11   HGNC cytogenetic band: 16p13.1

ABCC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ABCC1 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P016043:  view genomic region     (about GC identifiers)

Start:
 16,043,434 bp from pter      End:
 16,236,931 bp from pter
Size:
 193,498 bases      Orientation:
 plus strand

Proteins
for ABCC1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: MRP1_HUMAN, P33527 (See protein sequence)
Recommended Name: Multidrug resistance-associated protein 1  
Size: 1531 amino acids; 171591 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
1 PDB 3D structure from and Proteopedia for ABCC1:
2CBZ (3D)    
Secondary accessions: A3RJX2 C9JPJ4 O14819 O43333 P78419 Q59GI9 Q9UQ97 Q9UQ99 Q9UQA0
Alternative splicing: 9 isoforms:  P33527-1   P33527-2   P33527-3   P33527-4   P33527-5   P33527-6   P33527-7   P33527-8   
P33527-9   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ABCC1: NX_P33527

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P33527

    • 2 DME Specific Peptides for ABCC1 (P33527)
     SVGQRQL  LSGGQKQRV 

    ABCC1 Protein expression data from MOPED and PaxDb:    About this image 
    ABCC1 Protein Expression
    REFSEQ proteins: NP_004987.2  
    ENSEMBL proteins: 
     ENSP00000382342   ENSP00000461615   ENSP00000459693   ENSP00000382340   ENSP00000263019  
     ENSP00000263017   ENSP00000263014   ENSP00000263016  
    Reactome Protein details: P33527
    Human Recombinant Protein Products for ABCC1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: ABCC1
    OriGene Custom Protein Services for ABCC1 
    GenScript Custom Purified and Recombinant Proteins Services for ABCC1
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for ABCC1

    Gene Ontology (GO): 5/10 cellular component terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005624membrane fraction ----
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm ----
    GO:0005794Golgi apparatus IDA--

    ABCC1 for ontologies           About GeneDecksing



    ABCC1 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of ABCC1
    R&D Systems Antibodies for ABCC1 (MRP1)
    OriGene Antibodies (see all 3): ABCC1
    OriGene Custom Antibody Services for ABCC1 
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    Novus Biologicals ABCC1 Antibodies
    Abcam antibodies for ABCC1 
    Uscn Antibodies for ABCC1
    ThermoFisher Antibodies for ABCC1

    Assay Products for ABCC1: 
    Browse Kits and Assays available from EMD Millipore
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    Browse OriGene Fluorogenic Cell Assay Kits
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    GenScript Custom Assay Services for ABCC1
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for ABCC1

    Protein Domains /
    Families
    for ABCC1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ABCC1 for domains           About GeneDecksing

    5/7 InterPro domains/families (see all 7):
     IPR003439 ABC_transporter-like
     IPR001140 ABC_transptr_TM_dom
     IPR003593 AAA+_ATPase
     IPR017940 ABC_transporter_type1
     IPR011527 ABC_transptrTM_dom_typ1

    Graphical View of Domain Structure for InterPro Entry P33527

    ProtoNet protein and cluster: P33527

    UniProtKB/Swiss-Prot: MRP1_HUMAN, P33527
    Similarity: Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily
    Similarity: Contains 2 ABC transmembrane type-1 domains
    Similarity: Contains 2 ABC transporter domains


    Function
    for ABCC1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MRP1_HUMAN, P33527
    Function: Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of
    glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs
    and other xenobiotics. Confers resistance to anticancer drugs. Hydrolyzes ATP with low efficiency

         Genatlas biochemistry entry for ABCC1:
    ATP binding cassettte superfamily,subfamily C (CFTR/MRP),member 1,ubiquitously expressed,with several alternatively
    spliced forms,also containing a CGG repeat in 5'utr

         Enzyme Numbers (IUBMB): EC 3.6.3.442 EC 3.6.32

         Gene Ontology (GO): 5/12 molecular function terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005215transporter activity TAS1360704
    GO:0005324long-chain fatty acid transporter activity ----
    GO:0005524ATP binding IEA--
    GO:0008559xenobiotic-transporting ATPase activity ----
    GO:0015238drug transmembrane transporter activity ----
         
    ABCC1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for ABCC1:
     Decreased Salmonella enterica   Increased S DNA content 

         6 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Abcc1):
     hematopoietic system  homeostasis/metabolism  immune system  mortality/aging  nervous system 
     other 

    ABCC1 for phenotypes           About GeneDecksing

    Animal Models:
         Mouse knock-outs for ABCC1: Abcc1tm1Bor Abcc1tm1Acs
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for ABCC1 

    miRNA
    Products:            		miRTarBase miRNAs that target ABCC1:
    hsa-mir-345 (MIRT003198), hsa-mir-134 (MIRT004494), hsa-mir-7 (MIRT003199)

    OriGene 3'-UTR Clone (see all 5): ABCC1
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ABCC1
    8/34 QIAGEN miScript miRNA Assays for microRNAs that regulate ABCC1 (see all 34):
    hsa-miR-330-5p hsa-miR-486-3p hsa-miR-1184 hsa-miR-133a hsa-miR-186 hsa-miR-3613-3p hsa-miR-326 hsa-miR-509-3-5p
    SwitchGear 3'UTR luciferase reporter plasmid: ABCC1 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ABCC1 (see all 7)
    OriGene shRNA RFP: ABCC1
    OriGene siRNA: ABCC1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ABCC1
    Sirion Biotech Custom design and validation of potent shRNA sequences against ABCC1 

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for ABCC1
    Sirion Biotech Customized adenovirus for overexpression of ABCC1 
    Sirion Biotech Customized adenovirus for potent knockdown of ABCC1

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ABCC1 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ABCC1 (see all 6)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 5): ABCC1 (NM_004996)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ABCC1 

    Cell Line
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    Search LifeMap BioReagents cell lines for ABCC1
    Sirion Biotech Customized stable knockdown cell line services for ABCC1 
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    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ABCC1


    Pathways & Interactions
    for ABCC1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/15 super-pathways (see all 15) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Irinotecan Pathway, Pharmacokinetics
    		Irinotecan Pathway, Pharmacokinetics1.00
    		Taxane Pathway, Pharmacokinetics0.30
    		Irinotecan Pathway0.73
    2Metabolism
    		Metabolism1.00
    		Metabolism of lipids and lipoproteins0.34
    3Acetaminophen Pathway, Pharmacokinetics
    		Pathway_PA165986194 -need delete1.00
    		Acetaminophen Pathway, Pharmacokinetics1.00
    4Doxorubicin Pathway, Pharmacokinetics
    		Doxorubicin Pathway, Pharmacokinetics1.00
    		Doxorubicin Pathway (Cancer Cell), Pharmacodynamics0.43
    5ABC-family proteins mediated transport
    		ABC-family proteins mediated transport1.00
    		ABC transporters0.70

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    3 BioSystems Pathways for ABCC1 
        Irinotecan Pathway
    S1P1 pathway
    Sphingosine 1-phosphate (S1P) pathway

    5/6        Reactome Pathways for ABCC1 (see all 6)
        ABC-family proteins mediated transport
    Transmembrane transport of small molecules
    Metabolism
    Synthesis of Leukotrienes (LT) and Eoxins (EX)
    Arachidonic acid metabolism

    5/12 PharmGKB Pathways for ABCC1 (see all 12)
        Acetaminophen Pathway, Pharmacokinetics
    Doxorubicin Pathway (Cancer Cell), Pharmacodynamics
    Doxorubicin Pathway, Pharmacokinetics
    Etoposide Pathway, Pharmacokinetics/Pharmacodynamics
    Irinotecan Pathway, Pharmacokinetics

    2         Kegg Pathways  (Kegg details for ABCC1):
        ABC transporters
    Vitamin digestion and absorption


    ABCC1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ABCC1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    5/19 Interacting proteins for ABCC1 (P335273 ENSP000003823424) via UniProtKB, MINT, STRING, and/or I2D (see all 19)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UNC93B1Q9H1C43, ENSP000002274714I2D: score=1 STRING: ENSP00000227471
    TMEM173Q86WV63, ENSP000003312884I2D: score=1 STRING: ENSP00000331288
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    ATP2C1P981943I2D: score=1 
    AURKCQ9UQB93I2D: score=1 
    About this table

    Gene Ontology (GO): 5/17 biological process terms (GO ID links to tree view) (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006200ATP catabolic process IDA15999530
    GO:0006692prostanoid metabolic process ----
    GO:0006810transport TAS1360704
    GO:0006855drug transmembrane transport ----
    GO:0006979response to oxidative stress ----

    ABCC1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ABCC1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ABCC1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Enzo Life Sciences drugs & compounds for ABCC1

    Compounds for ABCC1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    ReversanSelective MRP1 and P-gp inhibitor[313397-13-6]
    MK 571Potent CysLT1 (LTD4) inverse agonist. Also MRP inhibitor[115104-28-4]

    1 HMDB Compound for ABCC1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Leukotriene C4(R-(R*,S*-(E,E,Z,Z)))-N-(S-(1-(4-carboxy-1-hydroxybutyl)-2,4,6,9-pentadecatetraenyl)-N-L-gamma-glutamyl-L-cysteinyl)-Glycine (see all 12)72025-60-6--

    10/49 DrugBank Compounds for ABCC1 (see all 49)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Daunorubicin-- 20830-81-3transportersubstrate inhibitor9188796 10729360 8621644 19944162 7945406 10188979 9281595 9647783 12657726 10708754 10917554 16830181 12867490 10917553
    ProbenecidProbenecid Acid (see all 2)57-66-9transporterinhibitor14511674 10500791 10727523 11118294 11880368 10329417 10419897 10917554 10363967
    DoxorubicinDoxorubicin HCl (see all 5)23214-92-8transportersubstrate inhibitor19725578 8621644 19390592 19255759 9281595 12657726 12867490 12765240
    SulfinpyrazoneDiphenylpyrazone (see all 6)57-96-5targetinhibitor10727523 11752352 15044619 9885294 10917554 9685354
    transporterinhibitor10727523 11752352 15044619 9885294 10917554 9685354 10917554
    Etoposide(-)-Etoposide (see all 3)33419-42-0transportersubstrate inhibitor11901101 9188796 19725578 9281595 12657726 12867490
    Vincristine22-Oxovincaleukoblastine (see all 12)57-22-7transportersubstrate inhibitor8621644 10188979 9281595 12657726 9058594 12867490
    IndomethacinIMN (see all 9)53-86-1transporterinhibitor12835412 14511674 16460798 11880368 10917554
    Genistein4',5, 7-Trihydroxyisoflavone (see all 4)446-72-0transporterinhibitor8980395 14511674 12532374 12373300
    Glutathione5-L-Glutamyl-L-cysteinylglycine (see all 5)70-18-8transportersubstrate inhibitor8640791 9188796 16539673 10917554
    Vinblastine-- 865-21-4transportersubstrate inhibitor inducer11834888 8621644 11323161 16458542

    10/131 Novoseek chemical compound relationships for ABCC1 gene (see all 131)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mk 571 94.1 88 15120939 (2), 17008412 (2), 7887949 (2), 10947971 (2) (see all 60)
    (glc)4 90.6 66 10427142 (3), 11810759 (3), 10408915 (2), 11159731 (2) (see all 33)
    estradiol-17beta-glucuronide 89.3 32 12388549 (2), 9281595 (2), 11278596 (1), 11278867 (1) (see all 22)
    daunorubicin 87.1 160 8616077 (4), 15176077 (4), 17204174 (4), 9443942 (3) (see all 70)
    vincristine 85.9 195 15896345 (7), 7923205 (5), 8937472 (4), 9664131 (4) (see all 99)
    doxorubicin 85.5 244 15880572 (9), 7923205 (3), 12964004 (3), 20190417 (3) (see all 99)
    probenecid 85.1 129 11322768 (5), 12218384 (3), 19454316 (2), 10999764 (2) (see all 74)
    rhodamine 123 84.8 62 10955805 (2), 9713968 (2), 11288109 (2), 15120939 (2) (see all 33)
    sb 30 83.3 9 11159731 (2), 10329417 (2), 10427142 (2), 11331074 (1) (see all 6)
    psc-833 82.1 15 10955805 (2), 11189941 (2), 9375571 (1), 17855498 (1) (see all 12)

    3 PharmGKB related drug/compound annotations for ABCC1 gene    About this table
    Drug/compound PharmGKB Annotation
    doxorubicinCA  
    methotrexateCA  
    montelukastCA  
    Search CenterWatch for drugs/clinical trials and news about ABCC1 / MRP1 

    Transcripts
    for ABCC1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ABCC1 gene (7 alternative transcripts): 
    NM_004996.3  NM_019862.2  NM_019898.2  NM_019899.2  NM_019900.2  NM_019901.1  NM_019902.1  

    Unigene Cluster for ABCC1:

    ATP-binding cassette, sub-family C (CFTR/MRP), member 1
    Hs.391464  [show with all ESTs]
    Unigene Representative Sequence: NM_004996
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000399410 ENST00000572882(uc021tdq.1 uc021tdr.1 uc021tds.1 uc021tdt.1)
    ENST00000574224(uc010bvn.3) ENST00000575422 ENST00000576557 ENST00000572053
    ENST00000574761 ENST00000399408(uc010bvi.3 uc002del.4) ENST00000346370(uc010bvk.3)
    ENST00000351154(uc010bvj.3) ENST00000345148(uc010bvl.3) ENST00000349029(uc010bvm.3)


    miRNA
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    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ABCC1
    8/34 QIAGEN miScript miRNA Assays for microRNAs that regulate ABCC1 (see all 34):
    hsa-miR-330-5p hsa-miR-486-3p hsa-miR-1184 hsa-miR-133a hsa-miR-186 hsa-miR-3613-3p hsa-miR-326 hsa-miR-509-3-5p
    SwitchGear 3'UTR luciferase reporter plasmid: ABCC1 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ABCC1 (see all 7)
    OriGene shRNA RFP: ABCC1
    OriGene siRNA: ABCC1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ABCC1
    Sirion Biotech Custom design and validation of potent shRNA sequences against ABCC1 
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ABCC1 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ABCC1 (see all 6)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 5): ABCC1 (NM_004996)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ABCC1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ABCC1 
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    Additional cDNA sequence: 

    AB209120.1 AJ003198.1 AK097871.1 AK311015.1 BC001636.1 BX648866.1 CR749835.1 HQ917064.1 
    HQ917065.1 HQ917066.1 HQ917067.1 L05628.1 X78338.1 

    24/25 DOTS entries (see all 25):

    DT.100817334  DT.101983347  DT.444581  DT.97799615  DT.102841888  DT.120692263  DT.102841978  DT.120692138 
    DT.102841295  DT.100817332  DT.120692056  DT.92040146  DT.99929967  DT.99930223  DT.100863932  DT.120691986 
    DT.40131770  DT.91757212  DT.92015144  DT.92050254  DT.95074693  DT.95257421  DT.95294943  DT.91925284 

    24/200 AceView cDNA sequences (see all 200):

    R63723 BM799798 CA488065 AI648621 AI798255 AL043477 AW270744 Z39651 
    BM145377 BM678021 BX280480 AI224066 BG698823 AI696452 BU176528 AA424804 
    BM738288 CF272373 AL706199 BM193098 BC001636 AA412168 BQ434553 BE873028 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for ABCC1    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21 ^ 22 ^
    SP1:                                                                                      -                                         -                 -         
    SP2:                                                                                      -                                                           -         
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            

    ExUns: 23 ^ 24a · 24b ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32a · 32b
    SP1:                                                                        
    SP2:                                                                        
    SP3:                                                                        
    SP4:                                                                        


    ECgene alternative splicing isoforms for ABCC1

    Expression
    for ABCC1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ABCC1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GTTATGAAGC
    ABCC1 Expression
    About this image

    ABCC1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BrainBlood Brain BarrierEndothelial CellsBlood Brain Barrier, Endothelium
    BrainChoroid PlexusMature Choroid Plexus CellsChoroid Plexus
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Mature brain microvascular endothelial cells (Derivation of blood-...)

    See ABCC1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ABCC1

    SOURCE GeneReport for Unigene cluster: Hs.391464

    UniProtKB/Swiss-Prot: MRP1_HUMAN, P33527
    Tissue specificity: Lung, testis and peripheral blood mononuclear cells

        SABiosciences Expression via Pathway-Focused PCR Arrays including ABCC1: 
              Cancer Drug Targets in human mouse rat
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              Molecular Toxicology PathwayFinder 384HT in human mouse rat
              Drug Metabolism in human mouse rat

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    In Situ
    Assay Products:     
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    Orthologs
    for ABCC1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ABCC1 gene from 9/33 species (see all 33)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves ABCC11 ATP-binding cassette, sub-family C (CFTR/MRP), member more 71.46(n)
    78.32(a)    		   395416  NM_001012522.1  NP_001012540.1 
    lizard
    (Anolis carolinensis)    		 Reptilia ABCC16
    		 --
    		 72(a)
    		 1 ↔ 1
    		 GL344209.1(2622-66795)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia Str.37482 Transcribed sequence with moderate similarity to protein more 74.52(n)    AL852319.2 
    zebrafish
    (Danio rerio)    		 Actinopterygii abcc11 ATP-binding cassette, sub-family C, member 1 67.5(n)
    71.17(a)    		   100002010  XM_001341859.3  XP_001341895.3 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG62143 xenobiotic-transporting ATPase 47(a)
    (best of 2)    		   33F4   --
    worm
    (Caenorhabditis elegans)    		 Secernentea mrp-21 , 3 ATP-binding transport family3
    Protein MRP-21    		 46(a)
    (best of 4)3
    51.27(n)1
    49.05(a)1    		   X(599137-607953)3
    1804081  NM_075720.41  NP_508121.11 
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes YCF11 Ycf1p 48.91(n)
    44.39(a)    		   851713   NP_010419.3 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons MRP81 multidrug resistance-associated protein 8 44.94(n)
    37.14(a)    		   820497  NM_112148.3  NP_187916.3 
    rice
    (Oryza sativa)    		 Liliopsida Os.56312 Transcribed sequence with moderate similarity to protein more 68.51(n)    CF196883.1 


    ENSEMBL Gene Tree for ABCC1 (if available)
    TreeFam Gene Tree for ABCC1 (if available) 

    Paralogs
    for ABCC1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ABCC1 gene
    ABCC42  ABCC122  ABCC102  CFTR2  ABCC82  ABCC52  ABCC32  ABCC62  
    ABCC22  ABCC112  ABCC92  
    18/23 SIMAP similar genes for ABCC1 using alignment to 7 protein entries:     MRP1_HUMAN (see all proteins) (see all similar genes):
    DKFZp781G125    MRP    TAP1    MRP3    ABCB4    DKFZp434I2115
    ABCC3    ABCC6    MOAT-B    NG-TRA    ABCC2    CFTR
    URG7    ABCC10    ara    ABCC4    ABCC13    ABCC8

    ABCC1 for paralogs           About GeneDecksing



    Genomic Variants
    for ABCC1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/4278 NCBI SNPs in ABCC1 are shown (see all 4278)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 16 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs727758271,2
    		C--16041576(+) AATCCA/CAATCC 1 -- us2k10--------
    rs1818547231,2
    		--16041608(+) GCTATA/GTAAGA 1 -- us2k10--------
    rs1874107011,2
    		--16041613(+) ATAAGA/TGTAGC 1 -- us2k10--------
    rs129299771,2
    		C--16041620(+) TAGCAG/ATTTTA 1 -- us2k115Minor allele frequency- A:0.45NS NA WA CSA EA 560
    rs41483301,2
    		C,F,H--16041768(+) GACCCG/AGGCCA 1 -- us2k127Minor allele frequency- A:0.48NS EA NA WA CSA 2894
    rs1504186951,2
    		--16041793(+) GAAAAC/TAATCC 1 -- us2k10--------
    rs454510971,2
    		F--16041824(+) CTTCC-/CC    
       CTTCC    CTCGC     		1 -- us2k15Minor allele frequency- CCCTTCC:0.01NS 188
    rs1381206711,2
    		--16041827(+) TCCCTC/TGCTAG 1 -- us2k10--------
    rs455901311,2
    		C,F--16041828(+) CCCTCG/ACTAGG 1 -- us2k16Minor allele frequency- A:0.01NS WA 308
    rs454431951,2
    		C,F--16041851(+) GGGGAG/AGTCTC 1 -- us2k16Minor allele frequency- A:0.01NS WA 308

    HapMap Linkage Disequilibrium report for ABCC1 (16043434 - 16236931 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 13 variations for ABCC1
         11 CNVs: 87984 4926 3993 49662 87985 47993 77209 2204 66945 87983 38341
         2 Indels: 45403 77210
    Human Gene Mutation Database (HGMD): ABCC1

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    Disorders / Diseases
    for ABCC1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ABCC1 for disorders           About GeneDecksing

    OMIM gene information: 158343    OMIM disorders: --

    20/142 diseases for ABCC1 (see all 142):    About MalaCards
    dubin-johnson syndrome    diffuse large b-cell lymphoma    colchicine resistance    dna topoisomerase ii
    fibrous histiocytoma    non-small cell lung carcinoma    b-cell lymphomas    temporal lobe epilepsy
    malignant fibrous histiocytoma    status epilepticus    intrahepatic cholestasis    non-hodgkin lymphoma
    cholestasis    soft tissue sarcoma    intraocular retinoblastoma    intrahepatic cholestasis of pregnancy
    bladder transitional cell carcinoma    gastrointestinal stromal tumor    myeloid leukemia    transitional cell carcinoma

    3 diseases from the University of Copenhagen DISEASES database for ABCC1:
    Pseudoxanthoma elasticum     Cancer     Bilirubin metabolic disorder

    10/88 Novoseek disease relationships for ABCC1 gene (see all 88)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    dubin-johnson syndrome 71.7 8 8621134 (4), 10695015 (1), 8869738 (1)
    breast cancer 65 273 15517899 (4), 10697508 (4), 14659356 (4), 15718312 (4) (see all 99)
    cancer 64.7 262 9762421 (5), 8881943 (5), 9815925 (4), 11245443 (4) (see all 99)
    leukemia 63.6 108 8833393 (4), 7803281 (3), 10901300 (3), 9603996 (3) (see all 69)
    tumors 63.1 478 15269137 (6), 17359940 (5), 9182980 (5), 15838832 (5) (see all 99)
    colchicine resistance 56.5 1 9649117 (1)
    cancer lung 55 119 11585860 (5), 8647646 (5), 11410522 (5), 11776768 (5) (see all 62)
    pseudoxanthoma elasticum 52.4 6 11139250 (2), 11439001 (1), 12414644 (1), 16006996 (1)
    small cell lung cancer 50.9 34 9751266 (2), 16883578 (2), 15880572 (2), 8185674 (1) (see all 24)
    secondary aml 50.4 3 8618469 (1), 11167822 (1), 18418409 (1)

    Genetic Association Database (GAD): ABCC1
    Human Genome Epidemiology (HuGE) Navigator: ABCC1 (39 documents)

    Export disorders for ABCC1 gene to outside databases

    Publications
    for ABCC1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ABCC1 gene, integrated from 9 sources (see all 1719):
    (articles sorted by number of sources associating them with ABCC1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Multidrug resistance-associated protein: sequence correction. (PubMed id 8098549)1, 2, 3 Cole S.P.C. and Deeley R.G. (1993)
    2. Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line. (PubMed id 1360704)1, 2, 3 Cole S.P....Deeley R.G. (1992)
    3. Mutational analysis of ionizable residues proximal to the cytoplasmic interface of membrane spanning domain 3 of the multidrug resistance protein, MRP1 (ABCC1): glutamate 1204 is important for both the expression and catalytic activity of the transporter. (PubMed id 15208328)1, 2, 9 Situ D.... Cole S.P.C. (2004)
    4. Membrane topology of the multidrug resistance protein (MRP). A study of glycosylation-site mutants reveals an extracytosolic NH2 terminus. (PubMed id 9295302)1, 2, 9 Hipfner D.R.... Cole S.P.C. (1997)
    5. Identification of an amino acid residue in multidrug resistance protein 1 critical for conferring resistance to anthracyclines. (PubMed id 11278596)1, 2, 9 Zhang D.-W.... Deeley R.G. (2001)
    6. Influence of ABCB1, ABCC1, ABCC2, and ABCG2 haplotypes on the cellular exposure of nelfinavir in vivo. (PubMed id 16041239)1, 4, 9 Colombo S....Telenti A. (2005)
    7. NAD(P)H oxidase and multidrug resistance protein genetic polymorphisms are associated with doxorubicin-induced cardiotoxicity. (PubMed id 16330681)1, 4, 9 Wojnowski L....Hasenfuss G. (2005)
    8. Transmembrane helix 11 of multidrug resistance protein 1 (MRP1/ABCC1): identification of polar amino acids important for substrate specificity and binding of ATP at nucleotide binding domain 1. (PubMed id 15260484)1, 2, 9 Zhang D.-W....Deeley R.G. (2004)
    9. Identification of novel polymorphisms in the pM5 and MRP1 (ABCC1) genes at locus 16p13.1 and exclusion of both genes as responsible for pseudoxanthoma elasticum. (PubMed id 11139250)1, 2, 9 Perdu J. and Germain D.P. (2001)
    10. Characterization of a leukotriene C4 export mechanism in human platelets: possible involvement of multidrug resistance-associated protein 1. (PubMed id 10064732)1, 2, 9 Sjoelinder M.... Lindgren J.A. (1999)

    External Searches for ABCC1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing ABCC1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4363 HGNC: 51 AceView: ABCC1 Ensembl:ENSG00000103222 euGenes: HUgn4363
    ECgene: ABCC1 Kegg: 4363 H-InvDB: ABCC1

    Other Databases showing ABCC1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ABCC1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ABCC1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ABCC1 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/abcc1/
    ABCMdbhttp://abcmutations.hegelab.org/proteinDetails?uniprot_id=P33527

    Intellectual Property
    for ABCC1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ABCC1 gene:
    Search GeneIP for patents involving ABCC1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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