Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ABCC1 Gene

Aliases for ABCC1 Gene

  • ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 1 2 3
  • MRP1 3 4 6
  • MRP 3 4 6
  • Leukotriene C(4) Transporter 3 4
  • LTC4 Transporter 3 4
  • ATP-Binding Cassette Transporter Variant ABCC1delta-Ex13&14 3
  • ATP-Binding Cassette Transporter Variant ABCC1delta-Ex25&26 3
  • ATP-Binding Cassette Transporter Variant ABCC1delta-Ex13 3
  • ATP-Binding Cassette Transporter Variant ABCC1delta-Ex25 3
  • ATP-Binding Cassette Sub-Family C Member 1 4
  • Multidrug Resistance Associated Protein 1 2
  • Multidrug Resistance-Associated Protein 1 3
  • EC 3.6.3.44 63
  • EC 3.6.3 63
  • ABC29 3
  • ABCC 3
  • GS-X 3

External Ids for ABCC1 Gene

Previous HGNC Symbols for ABCC1 Gene

  • MRP
  • MRP1

Previous GeneCards Identifiers for ABCC1 Gene

  • GC16P015870
  • GC16P015325
  • GC16P016009
  • GC16P015950
  • GC16P016043
  • GC16P015437

Summaries for ABCC1 Gene

Entrez Gene Summary for ABCC1 Gene

  • The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a multispecific organic anion transporter, with oxidized glutatione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Alternatively spliced variants of this gene have been described but their full-length nature is unknown. [provided by RefSeq, Apr 2012]

GeneCards Summary for ABCC1 Gene

ABCC1 (ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 1) is a Protein Coding gene. Diseases associated with ABCC1 include intraocular retinoblastoma and dubin-johnson syndrome. Among its related pathways are Disease and MicroRNAs in cancer. GO annotations related to this gene include transporter activity and ATPase activity, coupled to transmembrane movement of substances. An important paralog of this gene is ABCC5.

UniProtKB/Swiss-Prot for ABCC1 Gene

  • Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers resistance to anticancer drugs. Hydrolyzes ATP with low efficiency.

Tocris Summary for ABCC1 Gene

  • ABCC1 (also known as multidrug resistance-associated protein 1, or MRP1), is a member of the human ABC transporter family that is involved in multidrug resistance.

Gene Wiki entry for ABCC1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ABCC1 Gene

Genomics for ABCC1 Gene

Regulatory Elements for ABCC1 Gene

Transcription factor binding sites by QIAGEN in the ABCC1 gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ABCC1 Gene

Start:
15,949,577 bp from pter
End:
16,143,074 bp from pter
Size:
193,498 bases
Orientation:
Plus strand

Genomic View for ABCC1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ABCC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ABCC1 Gene

Proteins for ABCC1 Gene

  • Protein details for ABCC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P33527-MRP1_HUMAN
    Recommended name:
    Multidrug resistance-associated protein 1
    Protein Accession:
    P33527
    Secondary Accessions:
    • A3RJX2
    • C9JPJ4
    • O14819
    • O43333
    • P78419
    • Q59GI9
    • Q9UQ97
    • Q9UQ99
    • Q9UQA0

    Protein attributes for ABCC1 Gene

    Size:
    1531 amino acids
    Molecular mass:
    171591 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for ABCC1 Gene

    Alternative splice isoforms for ABCC1 Gene

neXtProt entry for ABCC1 Gene

Proteomics data for ABCC1 Gene at MOPED

Selected DME Specific Peptides for ABCC1 Gene

Post-translational modifications for ABCC1 Gene

  • Ubiquitination at Lys303, Lys307, Lys315, Lys488, Lys503, Lys513, Lys636, Lys773, Lys814, Lys891, Lys908, Lys1322, Lys1333, Lys1360, Lys1369, and Lys1502
  • Glycosylation at Asn19, Asn23, and Asn1006
  • Modification sites at PhosphoSitePlus

Other Protein References for ABCC1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for ABCC1 (ABCC1)

Domains for ABCC1 Gene

Gene Families for ABCC1 Gene

HGNC:
  • ABCC :ATP binding cassette transporters / subfamily C
IUPHAR :

Suggested Antigen Peptide Sequences for ABCC1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P33527

UniProtKB/Swiss-Prot:

MRP1_HUMAN :
  • P33527
Domain:
  • Contains 2 ABC transmembrane type-1 domains.
  • Contains 2 ABC transporter domains.
Family:
  • Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
genes like me logo Genes that share domains with ABCC1: view

Function for ABCC1 Gene

Molecular function for ABCC1 Gene

GENATLAS Biochemistry: ATP binding cassettte superfamily,subfamily C (CFTR/MRP),member 1,ubiquitously expressed,with several alternatively spliced forms,also containing a CGG repeat in 5utr
UniProtKB/Swiss-Prot Function: Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers resistance to anticancer drugs. Hydrolyzes ATP with low efficiency.

Enzyme Numbers (IUBMB) for ABCC1 Gene

Gene Ontology (GO) - Molecular Function for ABCC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity TAS 1360704
GO:0005524 ATP binding IEA --
GO:0016887 ATPase activity IDA 15999530
GO:0042626 ATPase activity, coupled to transmembrane movement of substances IEA --
genes like me logo Genes that share ontologies with ABCC1: view
genes like me logo Genes that share phenotypes with ABCC1: view

Animal Models for ABCC1 Gene

MGI Knock Outs for ABCC1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ABCC1

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targeting and HOMER Transcription for ABCC1 Gene

Localization for ABCC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ABCC1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ABCC1 Gene COMPARTMENTS Subcellular localization image for ABCC1 gene
Compartment Confidence
plasma membrane 5
golgi apparatus 4
nucleus 4
extracellular 2
cytoskeleton 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for ABCC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IEA --
GO:0016020 membrane IDA 19946888
GO:0016021 integral component of membrane --
GO:0016323 basolateral plasma membrane IDA 24130369
genes like me logo Genes that share ontologies with ABCC1: view

Pathways for ABCC1 Gene

SuperPathways for ABCC1 Gene

Superpath Contained pathways
1 Defective BTD causes biotidinase deficiency
2 Irinotecan Pathway, Pharmacokinetics
3 Metabolism
4 Arachidonic acid metabolism
5 Methotrexate Pathway, Pharmacokinetics
genes like me logo Genes that share pathways with ABCC1: view

PCR Array Products

Gene Ontology (GO) - Biological Process for ABCC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006200 obsolete ATP catabolic process --
GO:0006691 leukotriene metabolic process TAS --
GO:0006766 vitamin metabolic process TAS --
GO:0006767 water-soluble vitamin metabolic process TAS --
GO:0006810 transport TAS 1360704
genes like me logo Genes that share ontologies with ABCC1: view

Compounds for ABCC1 Gene

(5) Tocris Compounds for ABCC1 Gene

Compound Action Cas Number
Fumitremorgin C Inhibitor of BCRP-mediated multidrug resistance [118974-02-0]
Ko 143 Potent and selective BCRP inhibitor [461054-93-3]
Probenecid MRP inhibitor [57-66-9]
PSC 833 Inhibitor of P-gp-mediated MDR [121584-18-7]
Reversan Selective MRP1 and P-gp inhibitor [313397-13-6]

(1) HMDB Compounds for ABCC1 Gene

Compound Synonyms Cas Number PubMed IDs
Leukotriene C4
  • (R-(R*,S*-(E,E,Z,Z)))-N-(S-(1-(4-carboxy-1-hydroxybutyl)-2,4,6,9-pentadecatetraenyl)-N-L-gamma-glutamyl-L-cysteinyl)-Glycine
72025-60-6

(55) Drugbank Compounds for ABCC1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Abiraterone
154229-19-3 transporter inhibitor
Aminohippurate
  • Aminohippurate Sodium
94-16-6 transporter substrate
Amprenavir
  • AMP
161814-49-9 transporter inhibitor
Atazanavir
  • Atazanavir sulfate
198904-31-3 transporter substrate inhibitor
Atorvastatin
134523-00-5 transporter substrate

(131) Novoseek inferred chemical compound relationships for ABCC1 Gene

Compound -log(P) Hits PubMed IDs
mk 571 94.1 66
(glc)4 90.6 45
estradiol-17beta-glucuronide 89.3 24
daunorubicin 87.1 109
vincristine 85.9 135

(3) PharmGKB related drug/compound annotations for ABCC1 Gene

Drug/compound Annotation
doxorubicin CA
methotrexate CA
montelukast CA
genes like me logo Genes that share compounds with ABCC1: view

Transcripts for ABCC1 Gene

Unigene Clusters for ABCC1 Gene

ATP-binding cassette, sub-family C (CFTR/MRP), member 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ABCC1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for ABCC1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ABCC1 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21 ^ 22 ^
SP1: - - -
SP2: - -
SP3:
SP4:

ExUns: 23 ^ 24a · 24b ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32a · 32b
SP1:
SP2:
SP3:
SP4:

Relevant External Links for ABCC1 Gene

GeneLoc Exon Structure for
ABCC1
ECgene alternative splicing isoforms for
ABCC1

Expression for ABCC1 Gene

mRNA expression in normal human tissues for ABCC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ABCC1 Gene

SOURCE GeneReport for Unigene cluster for ABCC1 Gene Hs.391464

mRNA Expression by UniProt/SwissProt for ABCC1 Gene

P33527-MRP1_HUMAN
Tissue specificity: Lung, testis and peripheral blood mononuclear cells
genes like me logo Genes that share expressions with ABCC1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for ABCC1 Gene

Orthologs for ABCC1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ABCC1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ABCC1 35
  • 98.91 (n)
  • 99.41 (a)
ABCC1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ABCC1 35
  • 88.78 (n)
  • 90.78 (a)
ABCC1 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ABCC1 35
  • 88.63 (n)
  • 91.64 (a)
MRP1 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Abcc1 35
  • 83.84 (n)
  • 88.47 (a)
Abcc1 16
Abcc1 36
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ABCC1 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ABCC1 36
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Abcc1 35
  • 83.03 (n)
  • 87.58 (a)
chicken
(Gallus gallus)
Aves ABCC1 35
  • 71.44 (n)
  • 78.32 (a)
ABCC1 36
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ABCC1 36
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.3748 35
zebrafish
(Danio rerio)
Actinopterygii abcc1 35
  • 67.5 (n)
  • 71.17 (a)
ABCC1 36
  • 70 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Sur 37
  • 47 (a)
CG6214 37
  • 47 (a)
worm
(Caenorhabditis elegans)
Secernentea mrp-2 35
  • 51.46 (n)
  • 49.25 (a)
mrp-8 36
  • 37 (a)
ManyToMany
mrp-7 37
  • 40 (a)
mrp-8 37
  • 42 (a)
mrp-2 37
  • 46 (a)
C18C4.2 37
  • 24 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YCF1 36
  • 40 (a)
OneToMany
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.3011 35
thale cress
(Arabidopsis thaliana)
eudicotyledons MRP5 35
  • 44.74 (n)
  • 37.9 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.4445 35
rice
(Oryza sativa)
Liliopsida Os.5631 35
Os03g0142800 35
  • 47.21 (n)
  • 38.83 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.28932 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.6283 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 53 (a)
ManyToMany
Species with no ortholog for ABCC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for ABCC1 Gene

ENSEMBL:
Gene Tree for ABCC1 (if available)
TreeFam:
Gene Tree for ABCC1 (if available)

Paralogs for ABCC1 Gene

Paralogs for ABCC1 Gene

genes like me logo Genes that share paralogs with ABCC1: view

Variants for ABCC1 Gene

Sequence variations from dbSNP and Humsavar for ABCC1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs35587 -- 16,045,857(+) GTGAA(C/T)GACAC synonymous-codon, reference
rs35588 -- 16,046,021(+) AGGGG(A/G)CGCTG intron-variant
rs35589 -- 16,046,653(+) TGTCA(C/G)TCTTA intron-variant
rs35590 -- 16,047,709(+) GCCCA(C/G)ACCCT intron-variant
rs35591 -- 16,047,953(+) GAGCA(A/C/G)CGCGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ABCC1 Gene

Variant ID Type Subtype PubMed ID
nsv435664 CNV Deletion 17901297
esv2714015 CNV Deletion 23290073
nsv457428 CNV Gain 19166990
dgv2614n71 CNV Gain 21882294
nsv833149 CNV Loss 17160897
nsv905402 CNV Gain 21882294
nsv457436 CNV Gain 19166990
nsv905405 CNV Gain 21882294
esv34006 CNV Loss 18971310
dgv2616n71 CNV Gain 21882294
nsv1745 CNV Insertion 18451855
esv2661498 CNV Deletion 23128226
esv28545 CNV Loss 19812545
nsv442392 CNV CNV 18776908
nsv905407 CNV Gain 21882294
esv2714022 CNV Deletion 23290073
esv2399145 CNV Deletion 18987734
esv2714023 CNV Deletion 23290073
esv2667672 CNV Deletion 23128226
esv2714024 CNV Deletion 23290073
esv1033070 CNV Insertion 17803354
esv2674034 CNV Deletion 23128226
nsv905411 CNV Loss 21882294
esv2714025 CNV Deletion 23290073
nsv905412 CNV Loss 21882294
esv2714026 CNV Deletion 23290073
esv2714027 CNV Deletion 23290073
dgv816e1 CNV Complex 17122850
dgv817e1 CNV Complex 17122850
dgv2617n71 CNV Loss 21882294
nsv905414 CNV Loss 21882294
nsv905415 CNV Gain 21882294
nsv905417 CNV Gain 21882294
dgv2618n71 CNV Gain 21882294
nsv457437 CNV Gain 19166990
nsv469785 CNV Complex 16826518
nsv905419 CNV Gain 21882294
nsv905421 CNV Gain 21882294

Relevant External Links for ABCC1 Gene

HapMap Linkage Disequilibrium report
ABCC1
Human Gene Mutation Database (HGMD)
ABCC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ABCC1 Gene

Disorders for ABCC1 Gene

(3) University of Copenhagen DISEASES for ABCC1 Gene

(88) Novoseek inferred disease relationships for ABCC1 Gene

Disease -log(P) Hits PubMed IDs
dubin-johnson syndrome 71.7 6
breast cancer 65 143
cancer 64.7 129
leukemia 63.6 84
tumors 63.1 210

Relevant External Links for ABCC1

Genetic Association Database (GAD)
ABCC1
Human Genome Epidemiology (HuGE) Navigator
ABCC1
genes like me logo Genes that share disorders with ABCC1: view

No data available for UniProtKB/Swiss-Prot for ABCC1 Gene

Publications for ABCC1 Gene

  1. Membrane topology of the multidrug resistance protein (MRP). A study of glycosylation-site mutants reveals an extracytosolic NH2 terminus. (PMID: 9295302) Hipfner D.R. … Cole S.P.C. (J. Biol. Chem. 1997) 3 4 23
  2. Characterization of a leukotriene C4 export mechanism in human platelets: possible involvement of multidrug resistance-associated protein 1. (PMID: 10064732) Sjoelinder M. … Lindgren J.A. (J. Lipid Res. 1999) 3 4 23
  3. Epitope insertion favors a six transmembrane domain model for the carboxy-terminal portion of the multidrug resistance-associated protein. (PMID: 9485377) Kast C. … Gros P. (Biochemistry 1998) 3 4 23
  4. Identification of an amino acid residue in multidrug resistance protein 1 critical for conferring resistance to anthracyclines. (PMID: 11278596) Zhang D.-W. … Deeley R.G. (J. Biol. Chem. 2001) 3 4 23
  5. Mutation of a single conserved tryptophan in multidrug resistance protein 1 (MRP1/ABCC1) results in loss of drug resistance and selective loss of organic anion transport. (PMID: 11278867) Ito K. … Cole S.P.C. (J. Biol. Chem. 2001) 3 4 23

Products for ABCC1 Gene

Sources for ABCC1 Gene

Back to Top

Content