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Aliases for ABCC1 Gene

Aliases for ABCC1 Gene

  • ATP Binding Cassette Subfamily C Member 1 2 3 5
  • ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 1 2 3
  • Leukotriene C(4) Transporter 3 4
  • LTC4 Transporter 3 4
  • MRP1 3 4
  • MRP 3 4
  • ATP-Binding Cassette Transporter Variant ABCC1delta-Ex13&14 3
  • ATP-Binding Cassette Transporter Variant ABCC1delta-Ex25&26 3
  • ATP-Binding Cassette Transporter Variant ABCC1delta-Ex13 3
  • ATP-Binding Cassette Transporter Variant ABCC1delta-Ex25 3
  • ATP-Binding Cassette Sub-Family C Member 1 4
  • Multidrug Resistance Associated Protein 1 2
  • EC 3.6.3.44 63
  • EC 3.6.3 63
  • ABC29 3
  • ABCC 3
  • GS-X 3

External Ids for ABCC1 Gene

Previous HGNC Symbols for ABCC1 Gene

  • MRP
  • MRP1

Previous GeneCards Identifiers for ABCC1 Gene

  • GC16P015870
  • GC16P015325
  • GC16P016009
  • GC16P015950
  • GC16P016043
  • GC16P015437

Summaries for ABCC1 Gene

Entrez Gene Summary for ABCC1 Gene

  • The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a multispecific organic anion transporter, with oxidized glutatione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Alternatively spliced variants of this gene have been described but their full-length nature is unknown. [provided by RefSeq, Apr 2012]

GeneCards Summary for ABCC1 Gene

ABCC1 (ATP Binding Cassette Subfamily C Member 1) is a Protein Coding gene. Diseases associated with ABCC1 include dubin-johnson syndrome and microsporidiosis. Among its related pathways are Metabolism and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include transporter activity and ATPase activity, coupled to transmembrane movement of substances. An important paralog of this gene is ABCC3.

UniProtKB/Swiss-Prot for ABCC1 Gene

  • Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers resistance to anticancer drugs. Hydrolyzes ATP with low efficiency.

Tocris Summary for ABCC1 Gene

  • ATP-binding cassette (ABC) transporters form one of the largest groups of paralogous protein families that have a wide diversity of functions and substrates. Specificity has been shown for small and large molecules, highly charged molecules and highly hydrophobic systems.

Gene Wiki entry for ABCC1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ABCC1 Gene

Genomics for ABCC1 Gene

Regulatory Elements for ABCC1 Gene

Promoters for ABCC1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ABCC1 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the ABCC1 gene promoter:

Genomic Location for ABCC1 Gene

Chromosome:
16
Start:
15,949,577 bp from pter
End:
16,143,074 bp from pter
Size:
193,498 bases
Orientation:
Plus strand

Genomic View for ABCC1 Gene

Genes around ABCC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ABCC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ABCC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ABCC1 Gene

Proteins for ABCC1 Gene

  • Protein details for ABCC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P33527-MRP1_HUMAN
    Recommended name:
    Multidrug resistance-associated protein 1
    Protein Accession:
    P33527
    Secondary Accessions:
    • A3RJX2
    • C9JPJ4
    • O14819
    • O43333
    • P78419
    • Q59GI9
    • Q9UQ97
    • Q9UQ99
    • Q9UQA0

    Protein attributes for ABCC1 Gene

    Size:
    1531 amino acids
    Molecular mass:
    171591 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for ABCC1 Gene

    Alternative splice isoforms for ABCC1 Gene

neXtProt entry for ABCC1 Gene

Proteomics data for ABCC1 Gene at MOPED

Selected DME Specific Peptides for ABCC1 Gene

Post-translational modifications for ABCC1 Gene

  • Ubiquitination at Lys 303, Lys 307, Lys 315, Lys 488, Lys 503, Lys 513, Lys 636, Lys 773, Lys 814, Lys 891, Lys 908, Lys 1322, Lys 1333, Lys 1360, Lys 1369, and Lys 1502
  • Glycosylation at Asn 19, Asn 23, and Asn 1006
  • Modification sites at PhosphoSitePlus

Other Protein References for ABCC1 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for ABCC1 (ABCC1)

Domains & Families for ABCC1 Gene

Gene Families for ABCC1 Gene

Suggested Antigen Peptide Sequences for ABCC1 Gene

Graphical View of Domain Structure for InterPro Entry

P33527

UniProtKB/Swiss-Prot:

MRP1_HUMAN :
  • Contains 2 ABC transmembrane type-1 domains.
  • Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
Domain:
  • Contains 2 ABC transmembrane type-1 domains.
  • Contains 2 ABC transporter domains.
Family:
  • Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
genes like me logo Genes that share domains with ABCC1: view

Function for ABCC1 Gene

Molecular function for ABCC1 Gene

GENATLAS Biochemistry:
ATP binding cassettte superfamily,subfamily C (CFTR/MRP),member 1,ubiquitously expressed,with several alternatively spliced forms,also containing a CGG repeat in 5utr
UniProtKB/Swiss-Prot Function:
Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers resistance to anticancer drugs. Hydrolyzes ATP with low efficiency.

Enzyme Numbers (IUBMB) for ABCC1 Gene

Gene Ontology (GO) - Molecular Function for ABCC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity TAS 1360704
genes like me logo Genes that share ontologies with ABCC1: view
genes like me logo Genes that share phenotypes with ABCC1: view

Animal Models for ABCC1 Gene

MGI Knock Outs for ABCC1:

Animal Model Products

CRISPR Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ABCC1 Gene

Localization for ABCC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ABCC1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ABCC1 Gene COMPARTMENTS Subcellular localization image for ABCC1 gene
Compartment Confidence
extracellular 5
plasma membrane 5
nucleus 2
cytoskeleton 1
cytosol 1
endoplasmic reticulum 1
golgi apparatus 1
mitochondrion 1
vacuole 1

Gene Ontology (GO) - Cellular Components for ABCC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane IEA --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with ABCC1: view

Pathways & Interactions for ABCC1 Gene

genes like me logo Genes that share pathways with ABCC1: view

SIGNOR curated interactions for ABCC1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for ABCC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006691 leukotriene metabolic process TAS --
GO:0006766 vitamin metabolic process TAS --
GO:0008152 metabolic process IEA --
GO:0019369 arachidonic acid metabolic process TAS --
GO:0035461 vitamin transmembrane transport TAS --
genes like me logo Genes that share ontologies with ABCC1: view

Drugs & Compounds for ABCC1 Gene

(118) Drugs for ABCC1 Gene - From: Novoseek, DrugBank, HMDB, FDA Approved Drugs, Tocris, PharmGKB, and DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Doxorubicin Approved, Investigational Pharma Transporter, substrate, inhibitor Topo II inhibitor,immunosuppresive antineoplastic antibiotic 1582
Methotrexate Approved Pharma Transporter, substrate, inhibitor Folate antagonist,inhibits DFHR, Cytotoxic agent 1444
Ritonavir Approved, Investigational Pharma Transporter, inhibitor, inducer HIV protease inhibitor 850
Sulfinpyrazone Approved Pharma modulator, Target, Transporter, inhibitor 0
Lamivudine Approved, Investigational Pharma Transporter, inhibitor Nucleoside analog reverse transcriptase inhibitor 594

(57) Additional Compounds for ABCC1 Gene - From: Novoseek, Tocris, and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Fumitremorgin C
  • SM-Q
118974-02-0
MK 571
115104-28-4
4'-Hydroxydiclofenac
  • (O-(2,6-Dichloro-4-hydroxyanilino)phenyl)acetic acid
  • 4'-Hydroxy diclofenac
  • 4'-OH DCF
  • {2-[(2,6-dichloro-4-hydroxyphenyl)amino]phenyl}acetic acid
64118-84-9
Leukotriene C4
  • (R-(R*,S*-(E,E,Z,Z)))-N-(S-(1-(4-carboxy-1-hydroxybutyl)-2,4,6,9-pentadecatetraenyl)-N-L-gamma-glutamyl-L-cysteinyl)-Glycine
  • 5S,6R-Ltc
  • 5S-Hydroxy,6R-(S-glutathionyl),7E,9E,11Z,14Z-eicosatetraenoate
  • 5S-Hydroxy,6R-(S-glutathionyl),7E,9E,11Z,14Z-eicosatetraenoic acid
  • L-gamma-Glutamyl-S-[(1R,2E,4E,6Z,9Z)-1-[(1S)-4-carboxy-1-hydroxybutyl]-2,4,6,9-pentadecatetraenyl]-L-cysteinyl-glycine
72025-60-6
O-Desmethylverapamil (D-702)
genes like me logo Genes that share compounds with ABCC1: view

Transcripts for ABCC1 Gene

Unigene Clusters for ABCC1 Gene

ATP-binding cassette, sub-family C (CFTR/MRP), member 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ABCC1 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21 ^ 22 ^
SP1: - - -
SP2: - -
SP3:
SP4:

ExUns: 23 ^ 24a · 24b ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32a · 32b
SP1:
SP2:
SP3:
SP4:

Relevant External Links for ABCC1 Gene

GeneLoc Exon Structure for
ABCC1
ECgene alternative splicing isoforms for
ABCC1

Expression for ABCC1 Gene

mRNA expression in normal human tissues for ABCC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ABCC1 Gene

This gene is overexpressed in Breast (29.1) and Nasal epithelium (28.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ABCC1 Gene



SOURCE GeneReport for Unigene cluster for ABCC1 Gene Hs.391464

mRNA Expression by UniProt/SwissProt for ABCC1 Gene

P33527-MRP1_HUMAN
Tissue specificity: Lung, testis and peripheral blood mononuclear cells.
genes like me logo Genes that share expression patterns with ABCC1: view

Protein tissue co-expression partners for ABCC1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for ABCC1 Gene

Orthologs for ABCC1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ABCC1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ABCC1 35
  • 98.91 (n)
  • 99.41 (a)
ABCC1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ABCC1 36
  • 91 (a)
OneToOne
ABCC1 35
  • 88.78 (n)
  • 90.78 (a)
dog
(Canis familiaris)
Mammalia ABCC1 35
  • 88.63 (n)
  • 91.64 (a)
MRP1 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Abcc1 36
  • 88 (a)
OneToOne
Abcc1 16
Abcc1 35
  • 83.84 (n)
  • 88.47 (a)
oppossum
(Monodelphis domestica)
Mammalia ABCC1 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ABCC1 36
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Abcc1 35
  • 83.03 (n)
  • 87.58 (a)
chicken
(Gallus gallus)
Aves ABCC1 36
  • 78 (a)
OneToOne
ABCC1 35
  • 71.44 (n)
  • 78.32 (a)
lizard
(Anolis carolinensis)
Reptilia ABCC1 36
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.3748 35
zebrafish
(Danio rerio)
Actinopterygii abcc1 35
  • 67.5 (n)
  • 71.17 (a)
ABCC1 36
  • 70 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG6214 37
  • 47 (a)
Sur 37
  • 47 (a)
worm
(Caenorhabditis elegans)
Secernentea mrp-8 36
  • 37 (a)
ManyToMany
C18C4.2 37
  • 24 (a)
mrp-2 37
  • 46 (a)
mrp-7 37
  • 40 (a)
mrp-8 37
  • 42 (a)
mrp-2 35
  • 51.46 (n)
  • 49.25 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YCF1 36
  • 40 (a)
OneToMany
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.3011 35
thale cress
(Arabidopsis thaliana)
eudicotyledons MRP5 35
  • 44.74 (n)
  • 37.9 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.4445 35
rice
(Oryza sativa)
Liliopsida Os.5631 35
Os03g0142800 35
  • 47.21 (n)
  • 38.83 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.28932 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.6283 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 53 (a)
ManyToMany
Species with no ortholog for ABCC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for ABCC1 Gene

ENSEMBL:
Gene Tree for ABCC1 (if available)
TreeFam:
Gene Tree for ABCC1 (if available)

Paralogs for ABCC1 Gene

Paralogs for ABCC1 Gene

genes like me logo Genes that share paralogs with ABCC1: view

Variants for ABCC1 Gene

Sequence variations from dbSNP and Humsavar for ABCC1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs112282109 - 16,071,715(+) GCGAC(A/G)GCCTG reference, missense
rs45511401 - 16,079,375(+) CGAAG(G/T)TGCTT reference, missense
rs41395947 - 16,007,895(+) GCCTT(C/G)TTTTT reference, missense
rs41494447 - 16,007,985(+) CAAAA(C/T)CAAAA reference, missense
VAR_013319 -

Structural Variations from Database of Genomic Variants (DGV) for ABCC1 Gene

Variant ID Type Subtype PubMed ID
nsv435664 CNV Deletion 17901297
esv2714015 CNV Deletion 23290073
nsv457428 CNV Gain 19166990
dgv2614n71 CNV Gain 21882294
nsv833149 CNV Loss 17160897
nsv905402 CNV Gain 21882294
nsv457436 CNV Gain 19166990
nsv905405 CNV Gain 21882294
esv34006 CNV Loss 18971310
dgv2616n71 CNV Gain 21882294
nsv1745 CNV Insertion 18451855
esv2661498 CNV Deletion 23128226
esv28545 CNV Loss 19812545
nsv442392 CNV CNV 18776908
nsv905407 CNV Gain 21882294
esv2714022 CNV Deletion 23290073
esv2399145 CNV Deletion 18987734
esv2714023 CNV Deletion 23290073
esv2667672 CNV Deletion 23128226
esv2714024 CNV Deletion 23290073
esv1033070 CNV Insertion 17803354
esv2674034 CNV Deletion 23128226
nsv905411 CNV Loss 21882294
esv2714025 CNV Deletion 23290073
nsv905412 CNV Loss 21882294
esv2714026 CNV Deletion 23290073
esv2714027 CNV Deletion 23290073
dgv816e1 CNV Complex 17122850
dgv817e1 CNV Complex 17122850
dgv2617n71 CNV Loss 21882294
nsv905414 CNV Loss 21882294
nsv905415 CNV Gain 21882294
nsv905417 CNV Gain 21882294
dgv2618n71 CNV Gain 21882294
nsv457437 CNV Gain 19166990
nsv469785 CNV Complex 16826518
nsv905419 CNV Gain 21882294
nsv905421 CNV Gain 21882294

Variation tolerance for ABCC1 Gene

Residual Variation Intolerance Score: 2.89% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.96; 59.78% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ABCC1 Gene

HapMap Linkage Disequilibrium report
ABCC1
Human Gene Mutation Database (HGMD)
ABCC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ABCC1 Gene

Disorders for ABCC1 Gene

MalaCards: The human disease database

(15) MalaCards diseases for ABCC1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
dubin-johnson syndrome
  • chronic idiopathic jaundice
microsporidiosis
  • infection by microspora
intraocular lymphoma
  • primary intraocular lymphoma
pseudoxanthoma elasticum
  • pseudoxanthoma elasticum, modifier of severity of
colchicine resistance
- elite association - COSMIC cancer census association via MalaCards
Search ABCC1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for ABCC1

Genetic Association Database (GAD)
ABCC1
Human Genome Epidemiology (HuGE) Navigator
ABCC1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ABCC1
genes like me logo Genes that share disorders with ABCC1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ABCC1 Gene

Publications for ABCC1 Gene

  1. Multidrug resistance-associated protein: sequence correction. (PMID: 8098549) Cole S.P.C. … Deeley R.G. (Science 1993) 2 3 4 67
  2. Human skeletal muscle drug transporters determine local exposure and toxicity of statins. (PMID: 19940267) Knauer M.J. … Tirona R.G. (Circ. Res. 2010) 3 25 26
  3. Vandetanib (Zactima, ZD6474) antagonizes ABCC1- and ABCG2-mediated multidrug resistance by inhibition of their transport function. (PMID: 19390592) Zheng L.S. … Fu L.W. (PLoS ONE 2009) 23 25 26
  4. Modulation of multidrug resistance protein 1 (MRP1/ABCC1)-mediated multidrug resistance by bivalent apigenin homodimers and their derivatives. (PMID: 19725578) Wong I.L. … Chow L.M. (J. Med. Chem. 2009) 23 25 26
  5. Zoledronic acid is synergic with vinblastine to induce apoptosis in a multidrug resistance protein-1 dependent way: an in vitro study. (PMID: 16458542) Yildiz M. … Bozcuk H. (Cell Biol. Int. 2006) 23 25 26

Products for ABCC1 Gene

Sources for ABCC1 Gene

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