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ABCC1 Gene

protein-coding GIFtS: 71

GC16P015950

ATP-binding cassette, sub-family C (CFTR/MRP), member 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: MRP, MRP1)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
ABC29 ^²
ABCC ^²
DKFZp686N04233 ^²
DKFZp781G125 ^²
GS-X ^¹, ²
MRP ^², ³, ⁵
MRP1 ^², ³, ⁵
OTTHUMP00000045904 ^²

Descriptions
ATP-binding cassette sub-family C member 1 ^³
ATP-binding cassette, sub-family C (CFTR/MRP), member 1 ^²
ATP-binding cassette, sub-family C, member 1 ^²
LTC4 transporter ^², ³
Leukotriene C(4) transporter ^², ³
multidrug resistance protein ^²
multiple drug resistance protein 1 ^²
multiple drug resistance-associated protein ^²

External Ids
HGNC: 51¹
Entrez Gene: 4363²
UniProtKB: P33527³
Ensembl: ENSG00000103222⁷

Search outside databases for aliases for ABCC1 gene

Previous GC identifers: GC16P015870 GC16P015325 GC16P016009

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for ABCC1:

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC)

transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes.

ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20,

White). This full transporter is a member of the MRP subfamily which is involved in multi-drug

resistance. This protein functions as a multispecific organic anion transporter, with oxidized

glutatione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also

transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Alternative

splicing by exon deletion results in several splice variants but maintains the original open

reading frame in all forms. [provided by RefSeq]

UniProtKB/Swiss-Prot: MRP1_HUMAN, P33527

Function: Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent

transport of glutathione and glutathione conjugates, leukotriene C4,

estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers

resistance to anticancer drugs. Hydrolyzes ATP with low efficiency

Gene Wiki entry for ABCC1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ABCC1 gene

Entrez Gene cytogenetic band: 16p13.1 Ensembl cytogenetic band: 16p13.11 HGNC cytogenetic band: 16p13.1

ABCC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 16 GeneLoc Exon Structure

GeneLoc location for GC16P015950: (about GC identifiers)

Start:	15,950,935 bp from pter
End:	16,144,432 bp from pter
Size:	193,498 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000016.8 NT_010393.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: MRP1_HUMAN, P33527 (See protein sequence)

Recommended Name: Multidrug resistance-associated protein 1

Size: 1531 amino acids; 171561 Da

Subcellular location: Cell membrane; Multi-pass membrane protein

PDB structures from and Proteopedia :

2CBZ (3D)

Secondary accessions: A3RJX2 O14819 O43333 P78419 Q59GI9 Q9UQ97 Q9UQ99 Q9UQA0

Alternative splicing: 9 isoforms: P33527-1 P33527-2 P33527-3 P33527-4 P33527-5 P33527-6 P33527-7 P33527-8

P33527-9 (Additional isoforms seem to exist. Experimental confirmation may be lacking for some isoforms)

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (5 alternative transcripts):

NP_004987.2 NP_063915.2 NP_063953.2 NP_063954.2 NP_063955.2

ENSEMBL proteins:

ENSP00000382342 ENSP00000382340 ENSP00000263018 ENSP00000263015 ENSP00000263019 ENSP00000263017

ENSP00000263014 ENSP00000263016

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (MRP1)
	Human Recombinant Proteins from Abnova (ABCC1)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005624	membrane fraction	TAS	1360704
GO:0005887	integral to plasma membrane	TAS	1360704
GO:0016020	membrane	IEA	--

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Antibodies for ABCC1:

	Invitrogen Antibodies for ABCC1
	Millipore Mono- and Polyclonal Antibodies for the study of ABCC1
	Sigma-Aldrich Antibody Arrays and Antibodies for ABCC1
	R&D Systems Antibodies for ABCC1 (MRP1)
	Antibodies from Abcam (MRP1), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (ABCC1)
	Novus Biologicals Antibody for ABCC1

Assays for ABCC1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry P33527

ProtoNet protein and cluster: P33527

UniProtKB/Swiss-Prot: MRP1_HUMAN, P33527

Similarity: Belongs to the ABC transporter family. Conjugate transporter (TC 3.A.1.208) subfamily

Similarity: Contains 2 ABC transmembrane type-1 domains

Similarity: Contains 2 ABC transporter domains

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ABCC1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ABCC1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 7): NM_004996

Applied Biosystems Silencer® siRNAs for ABCC1

Sigma-Aldrich siRNA and siRNA Panels for ABCC1

Sigma-Aldrich shRNA for ABCC1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 5): NM_004996
Myc/DDK tagged cDNA clones in CMV expression vector (see all 5): NM_004996
untagged cDNA clones in CMV expression vector (see all 7): NM_004996

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_004996

UniProtKB/Swiss-Prot: MRP1_HUMAN, P33527

Function: Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent

transport of glutathione and glutathione conjugates, leukotriene C4,

estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers

resistance to anticancer drugs. Hydrolyzes ATP with low efficiency

Genatlas biochemistry entry for ABCC1:

ATP binding cassettte superfamily,subfamily C (CFTR/MRP),member 1,ubiquitously expressed,with

several alternatively spliced forms,also containing a CGG repeat in 5'utr

5 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Abcc1):

hematopoietic system

homeostasis/metabolism

immune system

life span-post-weaning/aging

5 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0005215	transporter activity	TAS	1360704
GO:0005524	ATP binding	TAS	1360704
GO:0016887	ATPase activity	IDA	15999530
GO:0042626	ATPase activity, coupled to transmembrane movement of substances	TAS	1360704

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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3 Sigma-Aldrich "Your Favorite Gene" Pathways for ABCC1 (Your Favorite Gene powered by Ingenuity)

Hepatic Cholestasis
Purine Metabolism
NRF2-mediated Oxidative Stress Response

GeneDecks ABCC1 for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for ABCC1

2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006810	transport	TAS	1360704
GO:0042493	response to drug	TAS	1360704

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Sigma-Aldrich Small Molecules for ABCC1:

Inhibitor

Compounds for ABCC1 available from Tocris Bioscience

Compound	Action	CAS number
MK 571	Potent CysLT1 (LTD4) inverse agonist. Also MRP inhibitor	[115104-28-4]

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10/31 Novoseek chemical compound relationships for ABCC1 gene (see all 31 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
(glc)4	90.94	66	10427142 (3), 11810759 (3), 10408915 (2), 11159731 (2) (see all 33)
estradiol-17beta-glucuronide	89.69	32	12388549 (2), 9281595 (2), 11278596 (1), 11278867 (1) (see all 22)
rhodamine 123	83.98	60	10955805 (2), 9713968 (2), 11288109 (2), 15120939 (2) (see all 31)
sb 30	83.71	9	11159731 (2), 10329417 (2), 10427142 (2), 11331074 (1) (see all 6)
biricodar	82.09	9	11408511 (2), 9738565 (2), 12217752 (1), 12721757 (1) (see all 5)
gf 120918	79.11	12	10917553 (2), 11189941 (2), 15359574 (1), 11118294 (1) (see all 6)
s-(2,4-dinitrophenyl)glutathione	77.96	5	10077229 (1), 9762421 (1), 12950253 (1), 8692921 (1) (see all 5)
etoposide glucuronide	76.44	1	8869738 (1)
ly335979	76.32	2	12455064 (1), 10411602 (1)
ltc4	74.82	81	8621643 (5), 12682044 (4), 11898391 (3), 8910374 (3) (see all 30)

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10/16 PharmGKB drug compound relationships for ABCC1 gene (see all 16 )

Drug compound	PharmGKB Relations	PubMed IDs for articles supporting these relationships
chlorambucil	FA	9685354
colchicine	FA	7954421 7916458
daunorubicin	FA	7954421 7916458
doxorubicin	FA	7954421 8275468 7916458 9685354
epirubicin	FA	7954421
estrogens	PK	12042670
etoposide	FA	7954421 8640791 7915193 7809167 9685354 8275468 7916458
folic acid	FA	11585759 12486126
irinotecan	FA GN	10220571
leucovorin	FA	11585759 12486126

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ABCC1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ABCC1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 7): NM_004996

Sigma-Aldrich siRNA and siRNA Panels for ABCC1

Sigma-Aldrich shRNA for ABCC1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_004996 NM_019862 NM_019898 NM_019899 NM_019900

REFSEQ mRNAs for ABCC1 gene (5 alternative transcripts):

NM_004996.3 NM_019862.2 NM_019898.2 NM_019899.2 NM_019900.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_004996 NM_019862 NM_019898 NM_019899 NM_019900

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 5): NM_004996
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 5): NM_004996
                                 untagged cDNA clones in CMV expression vector (see all 7): NM_004996

Additional cDNA sequence:

AB209120.1 AJ003198.1 AK097871.1 AK311015.1 BC001636.1 BX648866.1 CR749835.1 L05628.1

X78338.1

24/26 DOTS entries (see all 26 ):

DT.100817334 DT.101983347 DT.444581 DT.97799615 DT.102841888 DT.102841978 DT.120692263 DT.102841295

DT.100817332 DT.120692056 DT.120692138 DT.99930223 DT.92040146 DT.99929967 DT.92015144 DT.120691986

DT.40131770 DT.91757212 DT.92024320 DT.92050254 DT.95074693 DT.95257421 DT.95294943 DT.100863932

24/200 AceView cDNA sequences (see all 200 ):

BM799798 BM193098 R63723 BM145377 BM678021 BC001636 AI224066 AI648621

AW270744 CA488065 AI798255 AA424804 BU176528 BM738288 AI696452 AL706199

AL043477 AA412168 BX280480 BQ434553 Z39651 CF272373 BG698823 X78338

highest scoring ESTs for ABCC1:

L05628 X78338 AA133518 AA306323 AA311707 AA312126 AA328314 AA399068 AA495876 AI123076

Unigene Cluster for ABCC1:

ATP-binding cassette, sub-family C (CFTR/MRP), member 1

Hs.709181 [show with all ESTs]

Unigene Representative Sequence: NM_004996

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for ABCC1

ExUns:	1	^	2a	·	2b	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14a	·	14b	^	15a	·	15b	^	16	^	17	^	18	^	19	^	20a	·	20b	^	21	^	22	^
SP1:																													-														-						-
SP2:																													-																				-
SP3:
SP4:

ExUns:	23	^	24a	·	24b	^	25	^	26	^	27	^	28	^	29	^	30	^	31	^	32a	·	32b
SP1:
SP2:
SP3:
SP4:

About this scheme

ECgene alternative splicing isoforms for ABCC1

8 Ensembl transcripts including schematic representations:

ENST00000399410 ENST00000399408 ENST00000349532 ENST00000353257 ENST00000346370 ENST00000351154

ENST00000345148 ENST00000349029

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

ABCC1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ABCC1

¹ / ² / ³

8 probe-sets matching ABCC1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
34017_s_at²^{, 3}	U95-A	1	1.00	1.00	0.75	0.46	AF022853	0.20	1.00	0.72	1
34016_s_at²^{, 3}	U95-A	1	1.00	1.00	0.92	1.31	X78338	1.00	1.00	1.00	1
1896_s_at²^{, 3}	U95-A	1	1.00	1.00	0.89	1.19	L05628	1.00	1.00	1.00	1
34384_at²^{, 3}	U95-A	1	1.00	1.00	0.91	1.07	AF022853	0.20	1.00	0.72	1
202805_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_004996	0.60	1.00	0.82	1
202804_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AI539710	0.80	1.00	0.91	1
202805_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
202804_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks ABCC1 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GTTATGAAGC

SOURCE GeneReport for Unigene cluster: Hs.709181
Expression variation in blood from EXPOLDB for ABCC1
UniProtKB/Swiss-Prot: MRP1_HUMAN, P33527
Tissue specificity: Lung, testis and peripheral blood mononuclear cells

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ABCC1 gene from 5/23 species (see all 23 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ABCC1¹	--	ATP-binding cassette, sub-family C (CFTR/MRP), member more	88.63(n) 91.64(a)	403453 NM_001002971.1 NP_001002971.1
chimpanzee (Pan troglodytes)	ABCC1¹	--	ATP-binding cassette, sub-family C (CFTR/MRP), member more	98.91(n) 99.41(a)	453952 XM_001145351.1 XP_001145351.1
cow (Bos taurus)	ABCC1¹	--	ATP-binding cassette, sub-family C (CFTR/MRP), member more	88.76(n) 90.78(a)	281588 NM_174223.1 NP_776648.1
rat (Rattus norvegicus)	Abcc1¹	--	ATP-binding cassette, sub-family C (CFTR/MRP), member more	83.03(n) 87.58(a)	24565 NM_022281.2 NP_071617.2
mouse (Mus musculus)	Abcc1^{1, 5}	16⁵	ATP-binding cassette, sub-family C (CFTR/MRP), member more^{1, 5}	83.84(n)¹ 88.47(a)¹	17250¹ NM_008576.2¹ NP_032602.1¹ AA473585⁵ AF022908⁵ (see all 19)

About this table Species with no ortholog for ABCC1

ENSEMBL Gene Tree for ABCC1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for ABCC1 gene

ABCC3² ABCC6² ABCC2²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/1933 NCBI SNPs in ABCC1 are shown (see all 1933 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 386)

AB	SNP ID	Valid	Chr 16 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs212090^1,2	A,C,F,H,O	16143505(+)	`TACTGA/TTCCCA`	5	--	ut3¹		19	EA MN EU WA NA NS	2810
	rs212091^1,2	A,C,F,H	16144151(-)	`CCTTAA/GAGAAC`	5	--	ut3¹		17	EA NA MN EU WA	1342
	rs504348^1,2	C,F,H,O	15950675(-)	`CAAATC/GCTGTT`	5	--	ng5¹		6	MN EU EA WA	724
	rs3743527^1,2	A,C,F,H	16143182(+)	`TCTCCC/TCTTGG`	5	--	ut3¹		14	MN EU EA WA NA NS	2414
	rs13337489^1,2	C,F,H	16116184(+)	`CCGCTG/CTCTGC`	5	S/C	mis¹ ese³		14	EU EA WA NS	1058
	rs4148380^1,2	C,F,H	16143932(+)	`GACACG/AAAAAG`	5	--	ut3¹		20	NA EU EA WA NS	1590
	rs4148356^1,2	C,F,H	16084776(+)	`TCTCCG/AAGAAA`	5	Q/R	mis¹ int¹		20	EU EA WA NS	1868
	rs16967632^1,2	C,F,H	16144284(+)	`AAAACG/ACATAT`	5	--	ut3¹		16	NA EU EA WA NS	1172
	rs4148330^1,2	C,F,H	15949269(+)	`GACCCA/GGGCCA`	5	--	ng5¹		13	EU EA WA NS	1028
--	rs129081^1,2	A,C,F	16143440(+)	`ACCCCC/GACTCC`	5	--	ut3¹		8	EA MN NS	2188

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HapMap Linkage Disequilibrium images for ABCC1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 158343

10/88 Novoseek disease relationships for ABCC1 gene (see all 88 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
dubin-johnson syndrome	72.38	8	8621134 (4), 10695015 (1), 8869738 (1)
cancer	64.42	248	9762421 (5), 8881943 (5), 9815925 (4), 11245443 (4) (see all 99)
leukemia	64.23	107	8833393 (4), 7803281 (3), 10901300 (3), 9603996 (3) (see all 68)
breast cancer	63.63	234	15517899 (4), 10697508 (4), 14659356 (4), 15718312 (4) (see all 99)
tumors	63.27	442	15269137 (6), 17359940 (5), 15838832 (5), 9182980 (5) (see all 99)
colchicine resistance	57.18	1	9649117 (1)
cancer lung	55.53	115	11585860 (5), 8647646 (5), 11410522 (5), 11776768 (5) (see all 60)
secondary aml	51.98	3	8618469 (1), 11167822 (1), 18418409 (1)
pseudoxanthoma elasticum	51.72	6	11139250 (2), 11439001 (1), 12414644 (1), 16006996 (1)
small cell lung cancer	51.69	34	9751266 (2), 16883578 (2), 15880572 (2), 8185674 (1) (see all 24)

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2 PharmGKB disease relationships for ABCC1 gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Leukemia	FA	12486126
Leukemia, Lymphocytic, Acute, L1	PD	15630450

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Human Gene Mutation Database: ABCC1
Genetic Association Database: ABCC1
Human Genome Epidemiology Navigator: ABCC1 (17 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/1307 PubMed articles for ABCC1 gene (see all 1307 ):

Loss of multidrug resistance protein 1 expression and folate efflux activity results in a highly concentrative folate transport in human leukemia cells. (PubMed id 12486126)^{1, 3, 7} Assaraf Y.G....Jansen G. (2003)
The human multidrug resistance-associated protein MRP is a plasma membrane drug-efflux pump. (PubMed id 7916458)^{1, 3, 7} Zaman G.J....Broxterman H.J. (1994)
Multidrug resistance-associated protein: sequence correction. (PubMed id 8098549)^{2, 3, 4} Cole S.P.C. and Deeley R.G. (1993)
Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line. (PubMed id 1360704)^{2, 3, 4} Cole S.P....Deeley R.G. (1992)
Mutational analysis of ionizable residues proximal to the cytoplasmic interface of membrane spanning domain 3 of the multidrug resistance protein, MRP1 (ABCC1): glutamate 1204 is important for both the expression and catalytic activity of the transporter. (PubMed id 15208328)^{1, 3, 4} Situ D.... Cole S.P.C. (2004)
Membrane topology of the multidrug resistance protein (MRP). A study of glycosylation-site mutants reveals an extracytosolic NH2 terminus. (PubMed id 9295302)^{1, 3, 4} Hipfner D.R.... Cole S.P.C. (1997)
Identification of an amino acid residue in multidrug resistance protein 1 critical for conferring resistance to anthracyclines. (PubMed id 11278596)^{1, 3, 4} Zhang D.-W.... Deeley R.G. (2001)
Influence of ABCB1, ABCC1, ABCC2, and ABCG2 haplotypes on the cellular exposure of nelfinavir in vivo. (PubMed id 16041239)^{1, 3, 6} Colombo S....Telenti A. (2005)
Transmembrane helix 11 of multidrug resistance protein 1 (MRP1/ABCC1): identification of polar amino acids important for substrate specificity and binding of ATP at nucleotide binding domain 1. (PubMed id 15260484)^{1, 3, 4} Zhang D.-W....Deeley R.G. (2004)
Identification of novel polymorphisms in the pM5 and MRP1 (ABCC1) genes at locus 16p13.1 and exclusion of both genes as responsible for pseudoxanthoma elasticum. (PubMed id 11139250)^{1, 3, 4} Perdu J. and Germain D.P. (2001)

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Entrez Gene: 4363	HGNC: 51	AceView: ABCC1	Ensembl:ENSG00000103222	euGenes: HUgn4363
ECgene: ABCC1	H-InvDB: ABCC1

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
ATLAS Chromosomes in Cancer entry for ABCC1	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/abcc1/

Licensable Technologies for ABCC1
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
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Enzo Life Sciences, and/or Tocris Bioscience)
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Products for ABCC1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

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Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ABCC1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
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ABCC1 Gene

protein-coding GIFtS: 71

Aliases &
Descriptions
for ABCC1

Summaries
for ABCC1

Genomic Location
for ABCC1

Proteins
for ABCC1

Protein Domains/
Families
for ABCC1

Gene Function
for ABCC1

Pathways & Interactions
for ABCC1

Drugs & Compounds
for ABCC1

Transcripts
for ABCC1

Expression
for ABCC1

Orthologs
for ABCC1

Paralogs
for ABCC1

SNPs/Variants
for ABCC1

Disorders & Mutations
for ABCC1

Medical News
for ABCC1

Publications
for ABCC1

Search for ABCC1

Genome Databases showing ABCC1

Other Databases showing ABCC1

Specialized Databases showing ABCC1

Licensable Technologies
for ABCC1

Services
for ABCC1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ABCC1 Gene

protein-coding GIFtS: 71

Aliases & Descriptionsfor ABCC1

Summariesfor ABCC1

Genomic Locationfor ABCC1

Proteinsfor ABCC1

Protein Domains/Familiesfor ABCC1

Gene Functionfor ABCC1

Pathways & Interactionsfor ABCC1

Drugs & Compoundsfor ABCC1

Transcriptsfor ABCC1

Expression for ABCC1

Orthologsfor ABCC1

Paralogsfor ABCC1

SNPs/Variantsfor ABCC1

Disorders & Mutationsfor ABCC1

Medical Newsfor ABCC1

Publicationsfor ABCC1

Search for ABCC1

Genome Databases showing ABCC1

Other Databases showing ABCC1

Specialized Databases showing ABCC1

Licensable Technologiesfor ABCC1

Servicesfor ABCC1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ABCC1

Summaries
for ABCC1

Genomic Location
for ABCC1

Proteins
for ABCC1

Protein Domains/
Families
for ABCC1

Gene Function
for ABCC1

Pathways & Interactions
for ABCC1

Drugs & Compounds
for ABCC1

Transcripts
for ABCC1

Expression
for ABCC1

Orthologs
for ABCC1

Paralogs
for ABCC1

SNPs/Variants
for ABCC1

Disorders & Mutations
for ABCC1

Medical News
for ABCC1

Publications
for ABCC1

Licensable Technologies
for ABCC1

Services
for ABCC1