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Aliases for ABCC1 Gene

Aliases for ABCC1 Gene

  • ATP Binding Cassette Subfamily C Member 1 2 3 5
  • ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 1 2 3
  • Leukotriene C(4) Transporter 3 4
  • LTC4 Transporter 3 4
  • MRP1 3 4
  • MRP 3 4
  • ATP-Binding Cassette Transporter Variant ABCC1delta-Ex13&14 3
  • ATP-Binding Cassette Transporter Variant ABCC1delta-Ex25&26 3
  • ATP-Binding Cassette Transporter Variant ABCC1delta-Ex13 3
  • ATP-Binding Cassette Transporter Variant ABCC1delta-Ex25 3
  • ATP-Binding Cassette Sub-Family C Member 1 4
  • Multidrug Resistance Associated Protein 1 2
  • Multidrug Resistance-Associated Protein 1 3
  • EC 3.6.3.44 61
  • EC 3.6.3 61
  • ABC29 3
  • ABCC 3
  • GS-X 3

External Ids for ABCC1 Gene

Previous HGNC Symbols for ABCC1 Gene

  • MRP
  • MRP1

Previous GeneCards Identifiers for ABCC1 Gene

  • GC16P015870
  • GC16P015325
  • GC16P016009
  • GC16P015950
  • GC16P016043
  • GC16P015437

Summaries for ABCC1 Gene

Entrez Gene Summary for ABCC1 Gene

  • The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a multispecific organic anion transporter, with oxidized glutatione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Alternatively spliced variants of this gene have been described but their full-length nature is unknown. [provided by RefSeq, Apr 2012]

GeneCards Summary for ABCC1 Gene

ABCC1 (ATP Binding Cassette Subfamily C Member 1) is a Protein Coding gene. Diseases associated with ABCC1 include Microsporidiosis and Dubin-Johnson Syndrome. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Etoposide Pathway, Pharmacokinetics/Pharmacodynamics. GO annotations related to this gene include transporter activity and ATPase activity, coupled to transmembrane movement of substances. An important paralog of this gene is ABCC3.

UniProtKB/Swiss-Prot for ABCC1 Gene

  • Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers resistance to anticancer drugs. Hydrolyzes ATP with low efficiency.

Tocris Summary for ABCC1 Gene

  • ATP-binding cassette (ABC) transporters form one of the largest groups of paralogous protein families that have a wide diversity of functions and substrates. Specificity has been shown for small and large molecules, highly charged molecules and highly hydrophobic systems.

Gene Wiki entry for ABCC1 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ABCC1 Gene

Genomics for ABCC1 Gene

Regulatory Elements for ABCC1 Gene

Enhancers for ABCC1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16G015970 1.9 FANTOM5 Ensembl ENCODE dbSUPER 26.8 +24.7 24723 8.2 ZFP64 ETS1 CBX5 GATA2 ZNF143 FOS ZNF263 ZNF202 NFYC REST LOC100505915 ABCC1 PKD1P6 PKD1P1 FOPNL NPIPA5 RRN3 ENSG00000227827 NDE1 GC16P016010
GH16G015992 2 FANTOM5 Ensembl ENCODE dbSUPER 23.6 +47.3 47337 8.6 FOXA2 MLX ARID4B SIN3A DMAP1 SLC30A9 ZNF766 FOS SP5 ZHX2 ABCC1 ENSG00000183889 PKD1P1 RNU6-213P FOPNL LOC100505915 ENSG00000227827 NPIPA5 PKD1P6 NDE1
GH16G015986 1.9 FANTOM5 Ensembl ENCODE dbSUPER 24.1 +39.1 39076 4.2 HDGF PKNOX1 FOXA2 CREB3L1 ARNT SIN3A FEZF1 ZNF766 ZNF302 FOS ABCC1 RNU6-213P FOPNL MYH11 ENSG00000263065 NDE1 GC16P016010
GH16G015958 1.8 FANTOM5 Ensembl ENCODE dbSUPER 13.2 +13.6 13638 9.8 PKNOX1 DMAP1 ZNF48 ZNF121 CBX5 FOS MAFF ZNF585B RCOR2 KDM1A ABCC1 NDE1 FOPNL MYH11 GC16P016010
GH16G015897 1.6 Ensembl ENCODE dbSUPER 12.1 -50.0 -49968 4.5 HDGF FOXA2 PKNOX1 MLX SIN3A SLC30A9 FOS DEK ZNF263 ZHX2 ENSG00000262171 ABCC1 RNU6-213P MYH11 ENSG00000263065 FOPNL GC16M015891 RPL15P20
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ABCC1 on UCSC Golden Path with GeneCards custom track

Promoters for ABCC1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000083873 523 1801 HDGF ARID4B SIN3A DMAP1 ZNF2 GTF3C2 SLC30A9 FOS SMARCB1 TBX21

Transcription factor binding sites by QIAGEN in the ABCC1 gene promoter:

Genomic Location for ABCC1 Gene

Chromosome:
16
Start:
15,949,577 bp from pter
End:
16,143,074 bp from pter
Size:
193,498 bases
Orientation:
Plus strand

Genomic View for ABCC1 Gene

Genes around ABCC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ABCC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ABCC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ABCC1 Gene

Proteins for ABCC1 Gene

  • Protein details for ABCC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P33527-MRP1_HUMAN
    Recommended name:
    Multidrug resistance-associated protein 1
    Protein Accession:
    P33527
    Secondary Accessions:
    • A3RJX2
    • C9JPJ4
    • O14819
    • O43333
    • P78419
    • Q59GI9
    • Q9UQ97
    • Q9UQ99
    • Q9UQA0

    Protein attributes for ABCC1 Gene

    Size:
    1531 amino acids
    Molecular mass:
    171591 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for ABCC1 Gene

    Alternative splice isoforms for ABCC1 Gene

neXtProt entry for ABCC1 Gene

Selected DME Specific Peptides for ABCC1 Gene

P33527:
  • LSGGQKQRV
  • SVGQRQL

Post-translational modifications for ABCC1 Gene

  • Ubiquitination at posLast=303303, posLast=307307, Lys315, posLast=488488, posLast=503503, posLast=513513, Lys636, posLast=773773, posLast=814814, posLast=891891, posLast=908908, posLast=13221322, posLast=13331333, posLast=13601360, Lys1369, and posLast=15021502
  • Glycosylation at posLast=1919, posLast=2323, and Asn1006
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for ABCC1 (ABCC1)

Domains & Families for ABCC1 Gene

Gene Families for ABCC1 Gene

Suggested Antigen Peptide Sequences for ABCC1 Gene

Graphical View of Domain Structure for InterPro Entry

P33527

UniProtKB/Swiss-Prot:

MRP1_HUMAN :
  • Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
Family:
  • Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
genes like me logo Genes that share domains with ABCC1: view

Function for ABCC1 Gene

Molecular function for ABCC1 Gene

GENATLAS Biochemistry:
ATP binding cassettte superfamily,subfamily C (CFTR/MRP),member 1,ubiquitously expressed,with several alternatively spliced forms,also containing a CGG repeat in 5utr
UniProtKB/Swiss-Prot Function:
Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers resistance to anticancer drugs. Hydrolyzes ATP with low efficiency.

Enzyme Numbers (IUBMB) for ABCC1 Gene

Gene Ontology (GO) - Molecular Function for ABCC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity IEA,TAS 1360704
GO:0005524 ATP binding IEA --
GO:0008559 xenobiotic-transporting ATPase activity IBA --
GO:0015420 cobalamin-transporting ATPase activity TAS --
GO:0015431 glutathione S-conjugate-exporting ATPase activity IBA --
genes like me logo Genes that share ontologies with ABCC1: view
genes like me logo Genes that share phenotypes with ABCC1: view

Animal Models for ABCC1 Gene

MGI Knock Outs for ABCC1:

Animal Model Products

  • Taconic Biosciences Mouse Models for ABCC1

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ABCC1

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ABCC1 Gene

Localization for ABCC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ABCC1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ABCC1 gene
Compartment Confidence
plasma membrane 5
extracellular 5
nucleus 2
cytoskeleton 1
mitochondrion 1
cytosol 1

Gene Ontology (GO) - Cellular Components for ABCC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IDA,TAS --
GO:0005887 integral component of plasma membrane IEA,TAS --
GO:0016020 membrane IDA,IEA 19946888
GO:0016021 integral component of membrane IEA --
GO:0016323 basolateral plasma membrane IDA 24130369
genes like me logo Genes that share ontologies with ABCC1: view

Pathways & Interactions for ABCC1 Gene

genes like me logo Genes that share pathways with ABCC1: view

SIGNOR curated interactions for ABCC1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for ABCC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006691 leukotriene metabolic process TAS --
GO:0006810 transport IEA,TAS 1360704
GO:0006855 drug transmembrane transport IBA --
GO:0009235 cobalamin metabolic process TAS --
GO:0015889 cobalamin transport IEA --
genes like me logo Genes that share ontologies with ABCC1: view

Drugs & Compounds for ABCC1 Gene

(133) Drugs for ABCC1 Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, FDA Approved Drugs, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Doxorubicin Approved, Investigational Pharma Transporter, substrate, inhibitor Topo II inhibitor,immunosuppresive antineoplastic antibiotic 1751
Irinotecan Approved, Investigational Pharma Transporter, substrate Topoisomerase I inhibitor, TOPO I inhibitor, Topoisomerase 1 Inhibitors 1123
Methotrexate Approved Pharma Transporter, substrate, inhibitor Folate antagonist,inhibits DFHR 1551
Ritonavir Approved, Investigational Pharma Transporter, inhibitor, inducer HIV protease inhibitor 883
Sulfinpyrazone Approved Pharma modulator, Target, Transporter, inhibitor 0

(54) Additional Compounds for ABCC1 Gene - From: Novoseek, HMDB, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
4'-Hydroxydiclofenac
  • (O-(2,6-Dichloro-4-hydroxyanilino)phenyl)acetic acid
  • 4'-Hydroxy diclofenac
  • 4'-OH DCF
  • {2-[(2,6-dichloro-4-hydroxyphenyl)amino]phenyl}acetic acid
64118-84-9
Leukotriene C4
  • (R-(R*,S*-(E,E,Z,Z)))-N-(S-(1-(4-carboxy-1-hydroxybutyl)-2,4,6,9-pentadecatetraenyl)-N-L-gamma-glutamyl-L-cysteinyl)-Glycine
  • 5S,6R-Ltc
  • 5S-Hydroxy,6R-(S-glutathionyl),7E,9E,11Z,14Z-eicosatetraenoate
  • 5S-Hydroxy,6R-(S-glutathionyl),7E,9E,11Z,14Z-eicosatetraenoic acid
  • L-gamma-Glutamyl-S-[(1R,2E,4E,6Z,9Z)-1-[(1S)-4-carboxy-1-hydroxybutyl]-2,4,6,9-pentadecatetraenyl]-L-cysteinyl-glycine
72025-60-6
O-Desmethylverapamil (D-702)
Ceefourin 1
315702-40-0
PSC 833
121584-18-7

(5) Tocris Compounds for ABCC1 Gene

Compound Action Cas Number
Ceefourin 1 Selective MRP4 inhibitor 315702-40-0
Ko 143 Potent and selective BCRP inhibitor 461054-93-3
PSC 833 Inhibitor of P-gp-mediated MDR 121584-18-7
Reversan Selective MRP1 and P-gp inhibitor 313397-13-6
Tariquidar dihydrochloride Potent P-glycoprotein (P-gp) inhibitor

(9) ApexBio Compounds for ABCC1 Gene

Compound Action Cas Number
CP 100356 hydrochloride 142715-48-8
Dofequidar 129716-58-1
Dofequidar fumarate MDR reversal agent 153653-30-6
Fumitremorgin C 118974-02-0
KS 176 1253452-78-6
Reversan 313397-13-6
Tariquidar methanesulfonate, hydrate P-glycoprotein inhibitor, potent and selective 625375-83-9
Vinblastine sulfate Anti-mitotic agent 143-67-9
Zosuquidar MDR modulator 167354-41-8
genes like me logo Genes that share compounds with ABCC1: view

Drug Products

Transcripts for ABCC1 Gene

Unigene Clusters for ABCC1 Gene

ATP-binding cassette, sub-family C (CFTR/MRP), member 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ABCC1

Alternative Splicing Database (ASD) splice patterns (SP) for ABCC1 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21 ^ 22 ^
SP1: - - -
SP2: - -
SP3:
SP4:

ExUns: 23 ^ 24a · 24b ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32a · 32b
SP1:
SP2:
SP3:
SP4:

Relevant External Links for ABCC1 Gene

GeneLoc Exon Structure for
ABCC1
ECgene alternative splicing isoforms for
ABCC1

Expression for ABCC1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ABCC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ABCC1 Gene

This gene is overexpressed in Breast (29.1) and Nasal epithelium (28.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ABCC1 Gene



Protein tissue co-expression partners for ABCC1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ABCC1 Gene:

ABCC1

SOURCE GeneReport for Unigene cluster for ABCC1 Gene:

Hs.391464

mRNA Expression by UniProt/SwissProt for ABCC1 Gene:

P33527-MRP1_HUMAN
Tissue specificity: Lung, testis and peripheral blood mononuclear cells.

Evidence on tissue expression from TISSUES for ABCC1 Gene

  • Liver(4.5)
  • Nervous system(4.5)
  • Blood(2.6)
  • Lung(2.6)
  • Intestine(2.4)
  • Kidney(2)
genes like me logo Genes that share expression patterns with ABCC1: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ABCC1 Gene

Orthologs for ABCC1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ABCC1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ABCC1 34 35
  • 98.91 (n)
dog
(Canis familiaris)
Mammalia MRP1 35
  • 91 (a)
OneToOne
ABCC1 34
  • 88.63 (n)
cow
(Bos Taurus)
Mammalia ABCC1 34 35
  • 88.78 (n)
oppossum
(Monodelphis domestica)
Mammalia ABCC1 35
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ABCC1 35
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Abcc1 34 16 35
  • 83.84 (n)
rat
(Rattus norvegicus)
Mammalia Abcc1 34
  • 83.03 (n)
chicken
(Gallus gallus)
Aves ABCC1 34 35
  • 71.44 (n)
lizard
(Anolis carolinensis)
Reptilia ABCC1 35
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.3748 34
zebrafish
(Danio rerio)
Actinopterygii ABCC1 35
  • 70 (a)
OneToOne
abcc1 34
  • 67.5 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG6214 36
  • 47 (a)
Sur 36
  • 47 (a)
worm
(Caenorhabditis elegans)
Secernentea mrp-2 36 34
  • 51.46 (n)
mrp-8 36 35
  • 42 (a)
mrp-7 36
  • 40 (a)
C18C4.2 36
  • 24 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YCF1 35
  • 40 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons MRP5 34
  • 44.74 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.3011 34
rice
(Oryza sativa)
Liliopsida Os03g0142800 34
  • 47.21 (n)
Os.5631 34
barley
(Hordeum vulgare)
Liliopsida Hv.4445 34
wheat
(Triticum aestivum)
Liliopsida Ta.28932 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 53 (a)
ManyToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.6283 34
Species where no ortholog for ABCC1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for ABCC1 Gene

ENSEMBL:
Gene Tree for ABCC1 (if available)
TreeFam:
Gene Tree for ABCC1 (if available)

Paralogs for ABCC1 Gene

Paralogs for ABCC1 Gene

genes like me logo Genes that share paralogs with ABCC1: view

Variants for ABCC1 Gene

Sequence variations from dbSNP and Humsavar for ABCC1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs11075295 Uncertain significance 16,083,830(+) CCCCA(A/G)AAAGC intron-variant
rs11866794 Uncertain significance 16,075,717(+) TTCCT(A/C/G)TTCCG intron-variant
rs35623 Uncertain significance 16,075,608(+) cctgg(G/T)tgcag intron-variant
rs35625 Uncertain significance 16,075,709(+) TACCA(C/T)ACTTC intron-variant
rs35626 Uncertain significance 16,076,758(+) TTTCT(G/T)TGTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ABCC1 Gene

Variant ID Type Subtype PubMed ID
dgv4924n54 CNV gain 21841781
esv1033070 CNV insertion 17803354
esv2399145 CNV deletion 18987734
esv2661498 CNV deletion 23128226
esv2667672 CNV deletion 23128226
esv2674034 CNV deletion 23128226
esv2714015 CNV deletion 23290073
esv2714022 CNV deletion 23290073
esv2714023 CNV deletion 23290073
esv2714024 CNV deletion 23290073
esv2714025 CNV deletion 23290073
esv2714026 CNV deletion 23290073
esv2714027 CNV deletion 23290073
esv2758633 CNV gain+loss 17122850
esv2763133 CNV loss 21179565
esv28545 CNV loss 19812545
esv34006 CNV loss 18971310
esv3553169 CNV deletion 23714750
esv3553170 CNV deletion 23714750
esv3638041 CNV gain 21293372
esv3638047 CNV gain 21293372
esv3638048 CNV gain 21293372
esv3638049 CNV loss 21293372
esv3638050 CNV gain 21293372
esv3638051 CNV gain 21293372
esv3638052 CNV gain 21293372
nsv1047898 CNV loss 25217958
nsv1049647 CNV gain+loss 25217958
nsv1053451 CNV gain 25217958
nsv1070754 CNV deletion 25765185
nsv1121517 CNV deletion 24896259
nsv1125134 CNV deletion 24896259
nsv1134504 CNV deletion 24896259
nsv1745 CNV insertion 18451855
nsv435664 CNV deletion 17901297
nsv442392 CNV loss 18776908
nsv457428 CNV gain 19166990
nsv457436 CNV gain 19166990
nsv457437 CNV gain 19166990
nsv469785 CNV gain+loss 16826518
nsv472914 CNV novel sequence insertion 20440878
nsv571546 CNV loss 21841781
nsv571547 CNV gain 21841781
nsv833149 CNV loss 17160897

Variation tolerance for ABCC1 Gene

Residual Variation Intolerance Score: 2.89% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.96; 59.78% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ABCC1 Gene

Human Gene Mutation Database (HGMD)
ABCC1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ABCC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ABCC1 Gene

Disorders for ABCC1 Gene

MalaCards: The human disease database

(16) MalaCards diseases for ABCC1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
microsporidiosis
  • infection by microspora
dubin-johnson syndrome
  • chronic idiopathic jaundice
pseudoxanthoma elasticum
  • pseudoxanthoma elasticum, modifier of severity of
colchicine resistance
cholangiolocellular carcinoma
- elite association - COSMIC cancer census association via MalaCards
Search ABCC1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for ABCC1

Genetic Association Database (GAD)
ABCC1
Human Genome Epidemiology (HuGE) Navigator
ABCC1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ABCC1
genes like me logo Genes that share disorders with ABCC1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ABCC1 Gene

Publications for ABCC1 Gene

  1. 5-lipoxygenase pharmacogenetics in asthma: overlap with Cys-leukotriene receptor antagonist loci. (PMID: 19214143) Tantisira K.G. … Weiss S.T. (Pharmacogenet. Genomics 2009) 3 22 46 64
  2. Methotrexate (MTX) pathway gene polymorphisms and their effects on MTX toxicity in Caucasian and African American patients with rheumatoid arthritis. (PMID: 18381794) Ranganathan P. … McLeod H.L. (J. Rheumatol. 2008) 3 22 46 64
  3. Pharmacogenetic assessment of toxicity and outcome after platinum plus taxane chemotherapy in ovarian cancer: the Scottish Randomised Trial in Ovarian Cancer. (PMID: 17925548) Marsh S. … Brown R. (J. Clin. Oncol. 2007) 3 22 46 64
  4. NAD(P)H oxidase and multidrug resistance protein genetic polymorphisms are associated with doxorubicin-induced cardiotoxicity. (PMID: 16330681) Wojnowski L. … Hasenfuss G. (Circulation 2005) 3 22 46 64
  5. Influence of ABCB1, ABCC1, ABCC2, and ABCG2 haplotypes on the cellular exposure of nelfinavir in vivo. (PMID: 16041239) Colombo S. … Telenti A. (Pharmacogenet. Genomics 2005) 3 22 46 64

Products for ABCC1 Gene

  • Addgene plasmids for ABCC1

Sources for ABCC1 Gene

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