ABCC1 Gene
protein-coding GIFtS : 72
GCID: GC16 P016043
ATP-binding cassette, sub-family C (CFTR/MRP), member 1 (Previous name: multidrug resistance associated protein 1 ) (Previous symbols: MRP, MRP1 )
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Aliasesfor ABCC1 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 1 1 2 ATP-Binding Cassette Transporter Variant ABCC1delta-Ex132 MRP1 2 3 5 ATP-Binding Cassette Transporter Variant ABCC1delta-Ex13&142 MRP11 2 3 5 ATP-Binding Cassette Transporter Variant ABCC1delta-Ex252 GS-X1 2 ATP-Binding Cassette Transporter Variant ABCC1delta-Ex25&262 Leukotriene C(4) Transporter2 3 Multidrug Resistance-Associated Protein 12 LTC4 Transporter2 3 ATP-Binding Cassette Sub-Family C Member 13 Multidrug Resistance Associated Protein 11 EC 3.6.38 ABC292 EC 3.6.3.448 ABCC2
Export aliases for ABCC1 gene to outside databases Previous GC identifers: GC16P015870 GC16P015325 GC16P016009 GC16P015950 GC16P015437
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Summariesfor ABCC1 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for ABCC1 : The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a multispecific organic anion transporter, with oxidized glutatione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Alternatively spliced variants of this gene have been described but their full-length nature is unknown. (provided by RefSeq, Apr 2012) UniProtKB/Swiss-Prot: MRP1_HUMAN, P33527 Function : Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport ofglutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers resistance to anticancer drugs. Hydrolyzes ATP with low efficiency summary
for ABCC1 : ABCC1 (also known as multidrug resistance-associated protein 1, or MRP1), is a member of the human ABCtransporter family that is involved in multidrug resistance. Gene Wiki entry for ABCC1
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Genomic Viewsfor ABCC1 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000016.9 NC_018927.1 NT_010393.16 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the ABCC1 gene promoter: c-Fos AP-1 Other transcription factors Search SABiosciences Chromatin IP Primers for ABCC1 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat ABCC1
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 16p13.1 Ensembl cytogenetic band: 16p13.11 HGNC cytogenetic band: 16p13.1 ABCC1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 16 GeneLoc Exon Structure
GeneLoc location for GC16P016043: view genomic region
(about GC identifiers )
Start:
16,043,434 bp from pter
End:
16,236,931 bp from pter
Size:
193,498 bases
Orientation:
plus strand
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Proteinsfor ABCC1 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: MRP1_HUMAN, P33527 (See
protein sequence )Recommended Name: Multidrug resistance-associated protein 1 Size : 1531 amino acids; 171591 Da
Subcellular location : Cell membrane; Multi-pass membrane protein
1 PDB 3D structure from and Proteopedia for ABCC1 :2CBZ (3D)
 
Secondary accessions : A3RJX2 C9JPJ4 O14819 O43333 P78419 Q59GI9 Q9UQ97 Q9UQ99 Q9UQA0Alternative splicing : 9 isoforms : P33527-1 P33527-2 P33527-3 P33527-4 P33527-5 P33527-6 P33527-7 P33527-8 P33527-9 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for ABCC1: NX_P33527 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_P33527 2 DME Specific Peptides for ABCC1 (P33527 ) ABCC1 Protein expression data from MOPED and PaxDb : About this image REFSEQ proteins: NP_004987.2 ENSEMBL proteins: ENSP00000382342 ENSP00000461615 ENSP00000459693 ENSP00000382340 ENSP00000263019 ENSP00000263017 ENSP00000263014 ENSP00000263016 Reactome Protein details: P33527 Human Recombinant Protein Products for ABCC1: Gene Ontology (GO): 5/10 cellular component terms (GO ID links to tree view) (see all 10 ): About this table
ABCC1 for ontologies About GeneDecksing ABCC1 Antibody Products: Assay Products for ABCC1:
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Protein
Domains / Familiesfor ABCC1 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
ABCC1 for domains About GeneDecksing 5/7 InterPro domains/families (see all 7 ):
Graphical View of Domain Structure for InterPro Entry P33527 ProtoNet protein and cluster: P33527
UniProtKB/Swiss-Prot: MRP1_HUMAN, P33527 Similarity : Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamilySimilarity : Contains 2 ABC transmembrane type-1 domainsSimilarity : Contains 2 ABC transporter domains
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Functionfor ABCC1 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory ,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase ,
shRNA from
OriGene ,
Sirion Biotech ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Sirion Biotech ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
Sirion Biotech ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Molecular Function: UniProtKB/Swiss-Prot Summary: MRP1_HUMAN, P33527 Function : Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport ofglutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers resistance to anticancer drugs. Hydrolyzes ATP with low efficiency
Genatlas biochemistry entry for ABCC1 : ATP binding cassettte superfamily,subfamily C (CFTR/MRP),member 1,ubiquitously expressed,with several alternatively spliced forms,also containing a CGG repeat in 5'utr Enzyme Numbers (IUBMB): EC 3.6.3.44 2 EC 3.6.3 2 Gene Ontology (GO): 5/12 molecular function terms (GO ID links to tree view) (see all 12 ): About this table
ABCC1 for ontologies About GeneDecksing Phenotypes: 2 GenomeRNAi human phenotypes for ABCC1 : 6 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Abcc1) :
ABCC1 for phenotypes About GeneDecksing Animal Models: Mouse knock-outs for ABCC1: Abcc1 tm1Bor Abcc1 tm1Acs Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for ABCC1 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for ABCC1 (see all 6 )OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 5 ): ABCC1 (NM_004996 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ABCC1 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat ABCC1
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ABCC1
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Pathways & Interactionsfor ABCC1 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways  - 5/15 super-pathways (see all 15 ) About this table See pathways by source Super-pathway contained gene-specific pathways 1 Irinotecan Pathway, Pharmacokinetics 2 Metabolism 3 Acetaminophen Pathway, Pharmacokinetics 4 Doxorubicin Pathway, Pharmacokinetics 5 ABC-family proteins mediated transport
Pathway sources See GeneCards unified pathways Show all pathways 3 BioSystems Pathways for ABCC1 5/6
Reactome Pathways for ABCC1 (see all 6 )5/12 PharmGKB Pathways for ABCC1 (see all 12 )2
Kegg Pathways (Kegg details for ABCC1) :
ABCC1 for pathways About GeneDecksing Interactions: SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ABCC1 STRING Interaction
Network Preview (showing 5 interactants - click image to see 9)5/19 Interacting proteins for ABCC1 (P33527 3 ENSP00000382342 4 ) via UniProtKB, MINT, STRING , and/or I2D (see all 19 )About this table Gene Ontology (GO): 5/17 biological process terms (GO ID links to tree view) (see all 17 ): About this table
ABCC1 for ontologies About GeneDecksing
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Drugs & Compoundsfor ABCC1 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section
ABCC1 for compounds About GeneDecksing
Enzo Life Sciences drugs & compounds for ABCC1
Compounds for ABCC1 available from Tocris Bioscience About this table Compound Action
CAS
# Reversan Selective MRP1 and P-gp inhibitor [313397-13-6] MK 571 Potent CysLT1 (LTD4) inverse agonist. Also MRP inhibitor [115104-28-4]
1 HMDB Compound for ABCC1 About this table Compound Synonyms
CAS
# PubMed Ids Leukotriene C4 (R-(R*,S*-(E,E,Z,Z)))-N-(S-(1-(4-carboxy-1-hydroxybutyl)-2,4,6,9-pentadecatetraenyl)-N-L-gamma-glutamyl-L-cysteinyl)-Glycine (see all 12 ) 72025-60-6 --
10/49 DrugBank Compounds for ABCC1 (see all 49 ) About this table 10/131 Novoseek chemical compound relationships for ABCC1 gene (see all 131 ) About this table
Compound
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
mk 571
94.1
88
15120939 (2), 17008412 (2), 7887949 (2), 10947971 (2) (see all 60 )
(glc)4
90.6
66
10427142 (3), 11810759 (3), 10408915 (2), 11159731 (2) (see all 33 )
estradiol-17beta-glucuronide
89.3
32
12388549 (2), 9281595 (2), 11278596 (1), 11278867 (1) (see all 22 )
daunorubicin
87.1
160
8616077 (4), 15176077 (4), 17204174 (4), 9443942 (3) (see all 70 )
vincristine
85.9
195
15896345 (7), 7923205 (5), 8937472 (4), 9664131 (4) (see all 99 )
doxorubicin
85.5
244
15880572 (9), 7923205 (3), 12964004 (3), 20190417 (3) (see all 99 )
probenecid
85.1
129
11322768 (5), 12218384 (3), 19454316 (2), 10999764 (2) (see all 74 )
rhodamine 123
84.8
62
10955805 (2), 9713968 (2), 11288109 (2), 15120939 (2) (see all 33 )
sb 30
83.3
9
11159731 (2), 10329417 (2), 10427142 (2), 11331074 (1) (see all 6 )
psc-833
82.1
15
10955805 (2), 11189941 (2), 9375571 (1), 17855498 (1) (see all 12 )
3 PharmGKB related drug/compound annotations for ABCC1 gene About this table Search CenterWatch for drugs/clinical trials and news about ABCC1 / MRP1
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Transcriptsfor ABCC1 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
Sirion Biotech ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for ABCC1 gene (7 alternative transcripts): NM_004996.3 NM_019862.2 NM_019898.2 NM_019899.2 NM_019900.2 NM_019901.1 NM_019902.1 Unigene Cluster for ABCC1:
ATP-binding cassette, sub-family C (CFTR/MRP), member 1 Hs.391464 [show with all ESTs ] Unigene Representative Sequence: NM_004996 12 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000399410 ENST00000572882 (uc021tdq.1 uc021tdr.1 uc021tds.1 uc021tdt.1 )ENST00000574224 (uc010bvn.3 ) ENST00000575422 ENST00000576557 ENST00000572053 ENST00000574761 ENST00000399408 (uc010bvi.3 uc002del.4 ) ENST00000346370 (uc010bvk.3 )ENST00000351154 (uc010bvj.3 ) ENST00000345148 (uc010bvl.3 ) ENST00000349029 (uc010bvm.3 )Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for ABCC1 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for ABCC1 (see all 6 )OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 5 ): ABCC1 (NM_004996 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ABCC1 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat ABCC1
Additional cDNA sequence: AB209120.1 AJ003198.1 AK097871.1 AK311015.1 BC001636.1 BX648866.1 CR749835.1 HQ917064.1 HQ917065.1 HQ917066.1 HQ917067.1 L05628.1 X78338.1
24/25 DOTS entries (see all 25 ): DT.100817334 DT.101983347
DT.444581 DT.97799615 DT.102841888 DT.120692263 DT.102841978 DT.120692138 DT.102841295 DT.100817332 DT.120692056 DT.92040146 DT.99929967 DT.99930223 DT.100863932 DT.120691986 DT.40131770 DT.91757212 DT.92015144 DT.92050254 DT.95074693 DT.95257421 DT.95294943 DT.91925284 24/200 AceView cDNA sequences (see all 200 ):
R63723 BM799798 CA488065 AI648621 AI798255 AL043477 AW270744 Z39651 BM145377 BM678021 BX280480 AI224066 BG698823 AI696452 BU176528 AA424804 BM738288 CF272373 AL706199 BM193098 BC001636 AA412168 BQ434553 BE873028 GeneLoc Exon Structure 4 Alternative Splicing Database (ASD) splice patterns (SP) for ABCC1 About this scheme ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21 ^ 22 ^ SP1 :                             -               -       -     SP2 :                             -                     -     SP3 :                                                     SP4 :                                                    
ExUns: 23 ^ 24a · 24b ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32a · 32b SP1 :                         SP2 :                         SP3 :                         SP4 :                        
ECgene alternative splicing isoforms for ABCC1
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Expression for ABCC1 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section ABCC1 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: GTTATGAAGCAbout this image ABCC1 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table
See ABCC1 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for ABCC1 SOURCE GeneReport for Unigene cluster: Hs.391464 UniProtKB/Swiss-Prot: MRP1_HUMAN, P33527 Tissue specificity : Lung, testis and peripheral blood mononuclear cells SABiosciences Expression via Pathway-Focused PCR Arrays including ABCC1 : Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for ABCC1Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat ABCC1 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat ABCC1 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat ABCC1 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ABCC1
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Orthologsfor ABCC1 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of eukaryotes.
Orthologs for ABCC1 gene from 9/33 species (see all 33 ) About this table
Organism
Taxonomic classification
Gene
Description
Human Similarity
Orthology Type
Details
chicken (Gallus gallus)
Aves
ABCC11
ATP-binding cassette, sub-family C (CFTR/MRP), member more
71.46(n) 78.32(a)
 
395416 NM_001012522.1 NP_001012540.1
lizard (Anolis carolinensis)
Reptilia
ABCC16
--
72(a)
1 ↔ 1
GL344209.1(2622-66795)
tropical clawed frog (Xenopus tropicalis)
Amphibia
Str.37482
Transcribed sequence with moderate similarity to protein more
74.52(n)
 
AL852319.2
zebrafish (Danio rerio)
Actinopterygii
abcc11
ATP-binding cassette, sub-family C, member 1
67.5(n) 71.17(a)
 
100002010 XM_001341859.3 XP_001341895.3
fruit fly (Drosophila melanogaster)
Insecta
CG62143
xenobiotic-transporting ATPase
47(a) (best of 2)
 
33F4 --
worm (Caenorhabditis elegans)
Secernentea
mrp-21 , 3
ATP-binding transport family3 Protein MRP-21
46(a) (best of 4)3 51.27(n) 1 49.05(a) 1
 
X(599137-607953)3 180408 1 NM_075720.4 1 NP_508121.1 1
baker's yeast (Saccharomyces cerevisiae)
Saccharomycetes
YCF11
Ycf1p
48.91(n) 44.39(a)
 
851713 NP_010419.3
thale cress (Arabidopsis thaliana)
eudicotyledons
MRP81
multidrug resistance-associated protein 8
44.94(n) 37.14(a)
 
820497 NM_112148.3 NP_187916.3
rice (Oryza sativa)
Liliopsida
Os.56312
Transcribed sequence with moderate similarity to protein more
68.51(n)
 
CF196883.1
ENSEMBL Gene Tree for ABCC1 (if available)TreeFam Gene Tree for ABCC1 (if available)
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Paralogsfor ABCC1 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for ABCC1 gene ABCC4 2 ABCC12 2 ABCC10 2 CFTR 2 ABCC8 2 ABCC5 2 ABCC3 2 ABCC6 2 ABCC2 2 ABCC11 2 ABCC9 2 18/23 SIMAP similar genes for ABCC1 using alignment to 7 protein entries: MRP1_HUMAN (see all proteins )
(see all similar genes ):DKFZp781G125 MRP TAP1 MRP3 ABCB4 DKFZp434I2115 ABCC3 ABCC6 MOAT-B NG-TRA ABCC2 CFTR URG7 ABCC10 ara ABCC4 ABCC13 ABCC8
ABCC1 for paralogs About GeneDecksing
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Genomic Variantsfor ABCC1 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 16 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for ABCC1 (16043434 - 16236931 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 13 variations for ABCC1 11 CNVs : 87984 4926 3993 49662 87985 47993 77209 2204 66945 87983 38341 2 Indels : 45403 77210 Human Gene Mutation Database (HGMD) : ABCC1 SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing ABCC1
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Disorders
/ Diseasesfor ABCC1 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database , Novoseek ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
ABCC1 for disorders About GeneDecksing
OMIM gene information: 158343
OMIM disorders : --20/142 diseases for ABCC1 (see all 142 ): About MalaCards dubin-johnson syndrome diffuse large b-cell lymphoma colchicine resistance dna topoisomerase ii fibrous histiocytoma non-small cell lung carcinoma b-cell lymphomas temporal lobe epilepsy malignant fibrous histiocytoma status epilepticus intrahepatic cholestasis non-hodgkin lymphoma cholestasis soft tissue sarcoma intraocular retinoblastoma intrahepatic cholestasis of pregnancy bladder transitional cell carcinoma gastrointestinal stromal tumor myeloid leukemia transitional cell carcinoma 3 diseases from the University of Copenhagen DISEASES database for ABCC1 :Pseudoxanthoma elasticum Cancer Bilirubin metabolic disorder 10/88 Novoseek disease relationships for ABCC1 gene (see all 88 ) About this table
Disease
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
dubin-johnson syndrome
71.7
8
8621134 (4), 10695015 (1), 8869738 (1)
breast cancer
65
273
15517899 (4), 10697508 (4), 14659356 (4), 15718312 (4) (see all 99 )
cancer
64.7
262
9762421 (5), 8881943 (5), 9815925 (4), 11245443 (4) (see all 99 )
leukemia
63.6
108
8833393 (4), 7803281 (3), 10901300 (3), 9603996 (3) (see all 69 )
tumors
63.1
478
15269137 (6), 17359940 (5), 9182980 (5), 15838832 (5) (see all 99 )
colchicine resistance
56.5
1
9649117 (1)
cancer lung
55
119
11585860 (5), 8647646 (5), 11410522 (5), 11776768 (5) (see all 62 )
pseudoxanthoma elasticum
52.4
6
11139250 (2), 11439001 (1), 12414644 (1), 16006996 (1)
small cell lung cancer
50.9
34
9751266 (2), 16883578 (2), 15880572 (2), 8185674 (1) (see all 24 )
secondary aml
50.4
3
8618469 (1), 11167822 (1), 18418409 (1)
Genetic Association Database (GAD): ABCC1 Human Genome Epidemiology (HuGE) Navigator: ABCC1 (39 documents) Export disorders for ABCC1 gene to outside databases
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Publicationsfor ABCC1 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for ABCC1 gene, integrated from 9 sources (see all 1719 ): (articles sorted by number of sources associating them with ABCC1) Utopia : connect your pdf to the dynamic world of online information
Multidrug resistance-associated protein: sequence correction. (PubMed id 8098549) 1 , 2 , 3 Cole S.P.C. and Deeley R.G. (1993) Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line. (PubMed id 1360704) 1 , 2 , 3 Cole S.P....Deeley R.G. (1992) Mutational analysis of ionizable residues proximal to the cytoplasmic interface of membrane spanning domain 3 of the multidrug resistance protein, MRP1 (ABCC1): glutamate 1204 is important for both the expression and catalytic activity of the transporter. (PubMed id 15208328) 1 , 2 , 9 Situ D.... Cole S.P.C. (2004) Membrane topology of the multidrug resistance protein (MRP). A study of glycosylation-site mutants reveals an extracytosolic NH2 terminus. (PubMed id 9295302) 1 , 2 , 9 Hipfner D.R.... Cole S.P.C. (1997) Identification of an amino acid residue in multidrug resistance protein 1 critical for conferring resistance to anthracyclines. (PubMed id 11278596) 1 , 2 , 9 Zhang D.-W.... Deeley R.G. (2001) Influence of ABCB1, ABCC1, ABCC2, and ABCG2 haplotypes on the cellular exposure of nelfinavir in vivo. (PubMed id 16041239) 1 , 4, 9 Colombo S....Telenti A. (2005) NAD(P)H oxidase and multidrug resistance protein genetic polymorphisms are associated with doxorubicin-induced cardiotoxicity. (PubMed id 16330681) 1 , 4, 9 Wojnowski L....Hasenfuss G. (2005) Transmembrane helix 11 of multidrug resistance protein 1 (MRP1/ABCC1): identification of polar amino acids important for substrate specificity and binding of ATP at nucleotide binding domain 1. (PubMed id 15260484) 1 , 2 , 9 Zhang D.-W....Deeley R.G. (2004) Identification of novel polymorphisms in the pM5 and MRP1 (ABCC1) genes at locus 16p13.1 and exclusion of both genes as responsible for pseudoxanthoma elasticum. (PubMed id 11139250) 1 , 2 , 9 Perdu J. and Germain D.P. (2001) Characterization of a leukotriene C4 export mechanism in human platelets: possible involvement of multidrug resistance-associated protein 1. (PubMed id 10064732) 1 , 2 , 9 Sjoelinder M.... Lindgren J.A. (1999)
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External Searches for ABCC1 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing ABCC1 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
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Other Databases showing ABCC1 gene
(According to HUGE )
About This Section --
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Specialized Databases showing ABCC1 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for ABCC1 Pharmacogenomics, SNPs, Pathways ATLAS Chromosomes in Cancer entry for ABCC1 Genetics and Cytogenetics in Oncology and Haematology NIEHS-SNPs http://egp.gs.washington.edu/data/abcc1/ ABCMdb http://abcmutations.hegelab.org/proteinDetails?uniprot_id=P33527
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About This Section Patent Information for ABCC1 gene: Search GeneIP for patents involving ABCC1 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor ABCC1 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 and Sirion Biotech , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript , LifeMap BioReagents , and Sirion Biotech , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences , In Situ Hybridization Assays from Advanced Cell Diagnostics , Animal models from inGenious Targeting Laboratory )About This Section
OriGene Antibodies for ABCC1 OriGene shRNA RFP for ABCC1 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for ABCC1 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for ABCC1 OriGene Protein Over-expression Lysate for ABCC1 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for ABCC1 OriGene 3'-UTR Clone for ABCC1 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for ABCC1 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for ABCC1 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for ABCC1 OriGene Custom Protein Services for ABCC1 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ABCC1 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing ABCC1 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat ABCC1 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat ABCC1 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat ABCC1 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat ABCC1
Tocris compounds for ABCC1
ABCC1 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ABCC1
ThermoFisher Antibodies for ABCC1
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat ABCC1
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