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Aliases & Descriptions for ABCB9
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases EST122234 1 , 2 KIAA1520 2 , 3 TAPL 2 , 3 hABCB9 3
Descriptions ABC transporter 9 protein 3 ATP-binding cassette transporter 9 3 ATP-binding cassette, sub-family B (MDR/TAP), member 9 2 TAP-like protein 3
Search outside databases for aliases for ABCB9 genePrevious GC identifers: GC12M122118 GC12M123114 GC12M123221 GC12M121851
Summaries for ABCB9 (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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EntrezGene summary for ABCB9 : The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-bindingcassette (ABC) transporters. ABC proteins transport various molecules across extra- andintra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP,MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of theMDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. Thefunction of this half-transporter has not yet been determined; however, this protein may play arole in lysosomes. Alternative splicing of this gene results in distinct isoforms which are likelyto have different substrate specifications. [provided by RefSeq] UniProtKB/Swiss-Prot: ABCB9_HUMAN, Q9NP78 Function : May function as a peptide transporter
Gene Wiki entry for ABCB9
Genomic Location for ABCB9
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the ABCB9 gene Entrez Gene cytogenetic band: 12q24 Ensembl cytogenetic band: 12q24.31 HGNC cytogenetic band: 12q24 ABCB9 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 12 GeneLoc Exon Structure
GeneLoc location for GC12M121938:
(about GC identifiers )
Start:
121,979,492 bp from pter
End:
122,025,705 bp from pter
Size:
46,214 bases
Orientation:
minus strand
RefSeq DNA sequence: NC_000012.10 NT_009755.18 Proteins for ABCB9
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: ABCB9_HUMAN, Q9NP78 (See
protein sequence )Recommended Name: ATP-binding cassette sub-family B member 9 precursor Size : 766 amino acids; 84475 Da
Subunit : Homodimer or heterodimer (Potential)
Subcellular location : Endoplasmic reticulum membrane; Multi-pass membrane protein (Probable).Lysosome membrane; Multi-pass membrane protein
Secondary accessions : Q96AB1 Q9P208Alternative splicing : 3 isoforms : Q9NP78-1 Q9NP78-2 Q9NP78-3
Post-translational modifications:
View phosphorylation sites using PhosphoSite 2
REFSEQ proteins (3 alternative transcripts):
NP_062570.1 NP_062571.1 NP_982269.1 ENSEMBL proteins: ENSP00000376234 ENSP00000280560 ENSP00000280559 ENSP00000344339 Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 5/6 Gene Ontology (GO) cellular component terms (links to tree view) (see all 6
):
About this table Antibodies for ABCB9: Assays for ABCB9:
Protein
Domains/ Families for ABCB9(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry Q9NP78 ProtoNet protein and cluster: Q9NP78
UniProtKB/Swiss-Prot: ABCB9_HUMAN, Q9NP78 Similarity : Belongs to the ABC transporter family. MHC peptide exporter (TC 3.A.1.209) subfamilySimilarity : Contains 1 ABC transmembrane type-1 domainSimilarity : Contains 1 ABC transporter domain
Gene Function for ABCB9
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
OriGene ,
Sigma-Aldrich , RNAi from
Sigma-Aldrich ,
RNAi Products ,
Clones , and
Q-PCR Products
from Invitrogen ,
Millipore ,
OriGene , and/or
Abnova ,
siRNAs from
Applied Biosystems ,
SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 5 ): NM_019624 Applied Biosystems Silencer ® siRNAs for ABCB9 Sigma-Aldrich siRNA and siRNA Panels for ABCB9 Sigma-Aldrich shRNA for ABCB9 Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 3 ): NM_019624                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 3 ): NM_019624                                  untagged cDNA clones in CMV expression vector (see all 6 ): AL833963  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_019625 UniProtKB/Swiss-Prot: ABCB9_HUMAN, Q9NP78 Function : May function as a peptide transporter
Genatlas biochemistry entry for ABCB9 :ATP binding cassette superfamily,subfamily B (MDR/TAP),member 9 5/6 Gene Ontology (GO) molecular function terms (links to tree view) (see all 6
):
About this table
Pathways & Interactions for ABCB9
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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2 Sigma-Aldrich "Your Favorite Gene" Pathways for ABCB9 (Your Favorite Gene powered by Ingenuity) Gene Network CentralTM Interacting Genes and Proteins Network for ABCB9 5/10 Interacting proteins for ABCB9 (ENSP00000280560 3 ) via UniProtKB, MINT, and/or STRING (see all 10
)About this table 3 Gene Ontology (GO) biological process terms (links to tree view) :
About this table
Drugs & Compounds for ABCB9 (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Browse Tocris compounds for ABCB9 1 Novoseek chemical compound relationship for ABCB9 gene
About this table
Transcripts for ABCB9(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
Millipore , and/or
Abnova ,
siRNAs from Applied Biosystems ,
Sigma-Aldrich ,
shRNA from
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OriGene ,
Tagged/untagged cDNA clones from
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 5 ): NM_019624 Sigma-Aldrich siRNA and siRNA Panels for ABCB9 Sigma-Aldrich shRNA for ABCB9 Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_019624 NM_019625 NM_203444
REFSEQ mRNAs for ABCB9 gene (3 alternative transcripts): NM_019624.3 NM_019625.3 NM_203444.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_019624 NM_019625 NM_203444
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3 ): NM_019624                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 3 ): NM_019624                                  untagged cDNA clones in CMV expression vector (see all 6 ): AL833963  
Additional cDNA sequence: AB045381.2 AB112582.1 AB112583.1 AB177852.1 AF216494.1 AK027624.1 AK074738.1 AK294225.1 AK304295.1 AL833963.1 BC017348.2 BC064384.1 CR592700.1 CR614075.1 U66676.1
13 DOTS entries : DT.445295 DT.121179283 DT.102835395 DT.101982399 DT.100784195 DT.101982398 DT.100784197 DT.95368329 DT.97839872 DT.97839873 DT.100766524 DT.97860694 DT.99931925
24/67 AceView cDNA sequences (see all 67
):AK074738 CB149401 CB134746 BC064384 AI425047 NM_019624 BQ637312 CA503047 AB112583 CR592700 NM_203445 AK027624 BM821437 F06569 NM_019625 BX279993 CR614075 AL833963 BE504895 BM795184 NM_203444 AB112582 BM672327 AW139732
highest scoring ESTs for ABCB9 :AA669501 AA809482 AA906467 AB045381 AB112582 AB112583 AF216494 AI206549 AI369043 AI425047
Unigene Cluster for ABCB9: ATP-binding cassette, sub-family B (MDR/TAP), member 9 Hs.511951 [show with all ESTs ] Unigene Representative Sequence: BC064384 GeneLoc Exon Structure 5/8 Alternative Splicing Database (ASD) splice patterns (SP) for ABCB9 (see all 8
) ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14a · 14b · 14c ^ 15 ^ 16 ^ 17a · 17b SP1 :             -         -   -       -   -             -           SP2 :             -         -   -       -   -                       SP3 :                     -   -                               SP4 :                                     -       -           SP5 :                               -                      
About this scheme ECgene alternative splicing isoforms for ABCB9 4 Ensembl transcripts including schematic representations : ENST00000392439
ENST00000280560
ENST00000346530
ENST00000344275
Expression for ABCB9
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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ABCB9 expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for ABCB9 1 / 2 / 3
6 probe-sets matching ABCB9 gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: --SOURCE GeneReport for Unigene cluster: Hs.511951 Expression variation in blood from EXPOLDB for ABCB9
UniProtKB/Swiss-Prot: ABCB9_HUMAN, Q9NP78 Tissue specificity : Highly expressed in testis, and at moderate levels in brain, spinal cord, andthyroid
Orthologs for ABCB9
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for ABCB9 gene from 5/10 species (see all 10
)
Organism
Gene
Locus
Description
Human Similarity
NCBI accessions
dog (Canis familiaris)
ABCB91
--
ATP-binding cassette, sub-family B (MDR/TAP), member more
90.12(n) 93.34(a)
477456 XM_844280.1 XP_849373.1
chimpanzee (Pan troglodytes)
ABCB91
--
ATP-binding cassette, sub-family B (MDR/TAP), member more
99.52(n) 100(a)
452335 XM_509453.2 XP_509453.2
rat (Rattus norvegicus)
Abcb91
--
ATP-binding cassette, sub-family B (MDR/TAP), member more
89.46(n) 94.09(a)
63886 NM_022238.1 NP_071574.1
mouse (Mus musculus)
Abcb91 , 5
55
ATP-binding cassette, sub-family B (MDR/TAP), member more 1, 5
89.06(n) 1 94.23(a) 1
56325 1 NM_019875.2 1 NP_063928.2 1 AB045382 5 AB093298 5 (see all 10 )
chicken (Gallus gallus)
ABCB91
--
ATP-binding cassette, sub-family B (MDR/TAP), member more
76.15(n) 77.08(a)
416834 XM_415125.2 XP_415125.2
About this table Species with no ortholog for ABCB9 ENSEMBL Gene Tree for ABCB9 Paralogs for ABCB9 (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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Paralogs for ABCB9 gene ABCB10 2 ENSG00000220107 2
SNPs/Variants for ABCB9 (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for ABCB9 (up to first 250kb)
Disorders & Mutations for ABCB9
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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OMIM: 605453 Human Genome Epidemiology Navigator: ABCB9 (1 document)
Medical News for ABCB9 (Possibly Related Articles in
Doctor's Guide )
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--
Publications for ABCB9 (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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10/23 PubMed articles for ABCB9 gene (see all 23
): Characterization of ABCB9, an ATP binding cassette protein associated with lysosomes. (PubMed id 10748049) 1, 3, 4 Zhang F.... Ling V. (2000) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 3, 4 Gerhard D.S....Malek J. (2004) Large-scale characterization of HeLa cell nuclear phosphoproteins. (PubMed id 15302935) 3, 4 Beausoleil S.A....Gygi S.P. (2004) Three hundred twenty-six genetic variations in genes encoding nine members of ATP-binding cassette, subfamily B (ABCB/MDR/TAP), in the Japanese population. (PubMed id 11829140) 3, 4 Saito S.... Nakamura Y. (2002) A half-type ABC transporter TAPL is highly conserved between rodent and man, and the human gene is not responsive to interferon-gamma in contrast to TAP1 and TAP2. (PubMed id 11011155) 3, 4 Kobayashi A.... Maeda M. (2000) Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10819331) 3, 4 Nagase T....Ohara O. (2000) Characterization of the human ABC superfamily: isolation and mapping of 21 new genes using the expressed sequence tags database. (PubMed id 8894702) 2, 3 Allikmets R....Dean M. (1996) Gene organization of human transporter associated with antigen processing-like (TAPL, ABCB9): analysis of alternative splicing variants and promoter activity. (PubMed id 13679046) 1, 3 Kobayashi A.... Maeda M. (2003) Peptide specificity and lipid activation of the lysosomal transport complex ABCB9 (TAPL). (PubMed id 18434309) 1, 3 Zhao C....Abele R. (2008) Selective and ATP-dependent translocation of peptides by the homodimeric ATP binding cassette transporter TAP-like (ABCB9). (PubMed id 15863492) 1, 3 Wolters J.C....Tampe R. (2005)
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Genome Databases showing ABCB9
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
H-InvDB )
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Other Databases showing ABCB9
(According to HUGE )
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Specialized Databases showing ABCB9 (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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-- Services for ABCB9 (Reagents available from Applied Biosystems , Antibodies and assays by Cell
Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
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Products for ABCB9:
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