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Aliases & Descriptions for ABCB8
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| EST328128 1, 2 | | M-ABC1 1, 2, 3 | | MABC1 1, 2, 3, 5 |
| | | Descriptions |
|---|
| ATP-binding cassette, sub-family B (MDR/TAP), member 8 2 | | ATP-binding cassette, sub-family B, member 8 2 | | Mitochondrial ATP-binding cassette 1 3 | | mitochondrial ABC protein 2 |
|
| | Search outside databases for aliases for ABCB8 genePrevious GC identifers: GC07P148972 GC07P150040 GC07P150117 GC07P150164 |
Summaries for ABCB8(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for ABCB8: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. The function of this half-transporter has not yet been determined; however, it may involve the compartmentalization and transport of heme, as well as peptides, from the mitochondria to the nucleus and cytosol. This protein may also play a role in the transport of phospholipids into mitochondrial membranes. [provided by RefSeq] Gene Wiki entry for ABCB8 |
Genomic Location for ABCB8
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the ABCB8 gene 
Entrez Gene cytogenetic band: 7q36 Ensembl cytogenetic band: 7q36.1 HGNC cytogenetic band: 7q35-q36ABCB8 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07P150356:
(about GC identifiers)
Start:
|
150,356,443 bp from pter |
End:
|
150,375,802 bp from pter |
Size:
|
19,360 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr7+,CRA_TCAG 150,055,049-150,074,408 |
RefSeq DNA sequence:- NC_000007.12 NT_007914.14 NT_079596.2
| Proteins for ABCB8
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: ABCB8_HUMAN, Q9NUT2 (See
protein sequence)Recommended Name: ATP-binding cassette sub-family B member 8, mitochondrial precursor Size: 735 amino acids; 79989 Da
Subunit: Monomer (Potential)
Subcellular location: Mitochondrion inner membrane; Multi-pass membrane protein
Secondary accessions: B2RBL8 O95787 Q53GM0Alternative splicing: 2 isoforms: Q9NUT2-1 Q9NUT2-2 REFSEQ proteins: NP_009119.2
ENSEMBL proteins: ENSP00000297504 ENSP00000351717 ENSP00000353867 ENSP00000348353
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
5/7 Gene Ontology (GO) cellular component terms (links to tree view) (see all 7
): About this table
Antibodies for ABCB8: Assays for ABCB8: | Protein
Domains/ Families for ABCB8(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q9NUT2
ProtoNet protein and cluster: Q9NUT2 UniProtKB/Swiss-Prot: ABCB8_HUMAN, Q9NUT2Similarity: Belongs to the ABC transporter family. Multidrug resistance exporter (TC 3.A.1.201) subfamilySimilarity: Contains 1 ABC transmembrane type-1 domainSimilarity: Contains 1 ABC transporter domain | Gene Function for ABCB8
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_007188
Applied Biosystems Silencer® siRNAs for ABCB8
Sigma-Aldrich siRNA and siRNA Panels for ABCB8  Sigma-Aldrich shRNA for ABCB8  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_007188                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_007188                                  untagged cDNA clone in CMV expression vector: NM_007188 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_007188
Genatlas biochemistry entry for ABCB8:ATP binding cassette superfamily,subfamily B (MDR/TAP),member 8,ubiquitously expressed,located in mitochondrial inner membrane5 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for ABCB8
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
5/16 Interacting proteins for ABCB8 (Q9NUT22 ENSP000002975043) via UniProtKB, MINT, and/or STRING (see all 16
)About this table
1 Gene Ontology (GO) biological process term (links to tree view): About this table
|
Drugs & Compounds for ABCB8(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for ABCB8
|
Transcripts for ABCB8(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_007188
Sigma-Aldrich siRNA and siRNA Panels for ABCB8  Sigma-Aldrich shRNA for ABCB8  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_007188 REFSEQ mRNAs for ABCB8 gene: NM_007188.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_007188               OriGene GFP tagged cDNA clone in CMV expression vector: NM_007188                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_007188                                  untagged cDNA clone in CMV expression vector: NM_007188  Additional cDNA sequence: AF047690.1 AF086382.1 AK002018.1 AK024401.1 AK094005.1 AK094636.1 AK222911.1 AK294344.1 AK310796.1 AK314721.1 AL117497.1 BC141814.1 BC141836.1 BC151235.1 CR592221.1 CR595185.1 CR599833.1 CR610778.1 CR616094.1 U66688.1 22 DOTS entries: DT.100795794 DT.310230 DT.101984506 DT.112092 DT.100795799 DT.91750226 DT.100795798 DT.100028068 DT.121101666 DT.95376252 DT.100795797 DT.92426830 DT.121101698 DT.100795791 DT.102831874 DT.121101754 DT.102831873 DT.121101669 DT.121101676 DT.121101685 DT.121101688 DT.92051112 24/204 AceView cDNA sequences (see all 204
):CR595185 BM976848 BM703142 BM704396 BQ223720 CA944727 AA309016 BE384965 CA395398 BU155892 BQ718758 AK126885 AK094636 BU625433 AF195024 CR616094 BQ676865 AW960651 BC030282 AF195025 AK128129 BM552265 CA454776 CR592221
highest scoring ESTs for ABCB8:U66688 AA116009 AA190206 AA309016 AA719140 AF047690 AI083583 AI168486 AI420480 AI656922 Unigene Cluster for ABCB8: ATP-binding cassette, sub-family B (MDR/TAP), member 8 Hs.647118 [show with all ESTs]Unigene Representative Sequence: NM_007188
GeneLoc Exon Structure
5/27 Alternative Splicing Database (ASD) splice patterns (SP) for ABCB8 (see all 27
)
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | · | 2c | · | 2d | · | 2e | · | 2f | ^ | 3a | · | 3b | ^ | 4a | · | 4b | · | 4c | · | 4d | ^ | 5a | · | 5b | · | 5c | · | 5d | · | 5e | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c | ^ | |
| SP1: | |   | |   | |   | |   | - |   | - |   | - |   | - |   | - |   | - |   | |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | |   | |   | - |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
| ExUns: | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b | · | 14c | ^ | 15a | · | 15b | ^ | 16a | · | 16b | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21a | · | 21b | ^ | 22 | ^ | 23a | · | 23b | · | 23c | ^ | |
| SP1: | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | - |   | - |   | - |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | - |   | - |   | - |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | - |   | - |   | - |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | - |   | - |   | - |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
| ExUns: | 24 | ^ | 25 | ^ | 26 | ^ | 27a | · | 27b | ^ | 28a | · | 28b | ^ | 29 | ^ | 30 | ^ | 31 | ^ | 32a | · | 32b | · | 32c | |
| SP1: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for ABCB8
4 Ensembl transcripts including schematic representations: ENST00000297504
ENST00000358849
ENST00000360651
ENST00000356058
|
Expression for ABCB8
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| ABCB8 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for ABCB8
1 / 2 / 3 6 probe-sets matching ABCB8 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: --
SOURCE GeneReport for Unigene cluster: Hs.647118
Expression variation in blood from EXPOLDB for ABCB8 UniProtKB/Swiss-Prot: ABCB8_HUMAN, Q9NUT2Tissue specificity: Ubiquitous |
Orthologs for ABCB8
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for ABCB8 gene from 5/11 species (see all 11
)
| Organism |
Gene |
Locus |
Description |
Human Similarity |
NCBI accessions |
dog (Canis familiaris) |
ABCB81 |
-- |
ATP-binding cassette, sub-family B (MDR/TAP), member more |
86.12(n) 87.52(a) |
482800 XM_539916.2 XP_539916.2 |
chimpanzee (Pan troglodytes) |
ABCB81 |
-- |
ATP-binding cassette, sub-family B (MDR/TAP), member more |
99.31(n) 99.4(a) |
463892 XM_519524.2 XP_519524.2 |
rat (Rattus norvegicus) |
Abcb81 |
-- |
ATP-binding cassette, sub-family B (MDR/TAP), member more |
82.96(n) 83.33(a) |
362302 NM_001007796.1 NP_001007797.1 |
mouse (Mus musculus) |
Abcb81, 5 |
55
|
ATP-binding cassette, sub-family B (MDR/TAP), member more1, 5 |
82.89(n)1 84.38(a)1 |
746101 NM_029020.21 NP_083296.21 AA4098955 AA5445565 (see all 32) |
zebrafish (Danio rerio) |
Dr.184752 |
-- |
Transcribed sequence with moderate similarity to protein more |
74.02(n) |
BG303035.1 |
About this table Species with no ortholog for ABCB8
ENSEMBL Gene Tree for ABCB8 | Paralogs for ABCB8(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for ABCB8 gene
- TAP22 ENSG000001683942
|
SNPs/Variants for ABCB8(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for ABCB8 (up to first 250kb)
|
Disorders & Mutations for ABCB8
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 605464
Human Genome Epidemiology Navigator: ABCB8 (1 document)
|
Medical News for ABCB8(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for ABCB8 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/14 PubMed articles for ABCB8 gene (see all 14
):- Identification and characterization of a mammalian mitochondrial ATP- binding cassette membrane protein. (PubMed id 9878413)1, 3, 4 Hogue D.L.... Ling V. (1999)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)3, 4 Ota T....Sugano S. (2004)
- Three hundred twenty-six genetic variations in genes encoding nine members of ATP-binding cassette, subfamily B (ABCB/MDR/TAP), in the Japanese population. (PubMed id 11829140)3, 4 Saito S.... Nakamura Y. (2002)
- Characterization of the human ABC superfamily: isolation and mapping of 21 new genes using the expressed sequence tags database. (PubMed id 8894702)2, 3 Allikmets R....Dean M. (1996)
- ABCB8 mediates doxorubicin resistance in melanoma cells by protecting the mitochondrial genome. (PubMed id 19147539)3 Elliott A.M. and Al-Hajj M.A. (2009)
- Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects. (PubMed id 19343046)3 Saito A....Kamatani N. (2009)
- The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)4 Sjoeblom T.... Velculescu V.E. (2006)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)3 Kimura K.... Sugano S. (2006)
- A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)3 Stelzl U....Wanker E.E. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)4 Gerhard D.S....Malek J. (2004)
|
Search for ABCB8
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing ABCB8
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing ABCB8
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ABCB8(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for ABCB8(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for ABCB8:

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Incremental update: 13 Oct 2009
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