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ABCB8 Gene

protein-coding GIFtS: 57

GC07P150356

ATP-binding cassette, sub-family B (MDR/TAP), member 8
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
EST328128 ^¹, ²
M-ABC1 ^¹, ², ³
MABC1 ^¹, ², ³, ⁵

Descriptions
ATP-binding cassette, sub-family B (MDR/TAP), member 8 ^²
ATP-binding cassette, sub-family B, member 8 ^²
Mitochondrial ATP-binding cassette 1 ^³
mitochondrial ABC protein ^²

External Ids
HGNC: 49¹
Entrez Gene: 11194²
UniProtKB: Q9NUT2³
Ensembl: ENSG00000197150⁷

Search outside databases for aliases for ABCB8 gene

Previous GC identifers: GC07P148972 GC07P150040 GC07P150117 GC07P150164

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for ABCB8:

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding

cassette (ABC) transporters. ABC proteins transport various molecules across extra- and

intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP,

MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the

MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. The

function of this half-transporter has not yet been determined; however, it may involve the

compartmentalization and transport of heme, as well as peptides, from the mitochondria to the

nucleus and cytosol. This protein may also play a role in the transport of phospholipids into

mitochondrial membranes. [provided by RefSeq]

Gene Wiki entry for ABCB8

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ABCB8 gene

Entrez Gene cytogenetic band: 7q36 Ensembl cytogenetic band: 7q36.1 HGNC cytogenetic band: 7q35-q36

ABCB8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 7 GeneLoc Exon Structure

GeneLoc location for GC07P150356: (about GC identifiers)

Start:	150,356,443 bp from pter
End:	150,375,802 bp from pter
Size:	19,360 bases
Orientation:	plus strand

1 alternative location:

Chr7+,CRA_TCAG 150,055,049-150,074,408

RefSeq DNA sequence:

NC_000007.12 NT_007914.14 NT_079596.2

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: ABCB8_HUMAN, Q9NUT2 (See protein sequence)

Recommended Name: ATP-binding cassette sub-family B member 8, mitochondrial precursor

Size: 735 amino acids; 79989 Da

Subunit: Monomer (Potential)

Subcellular location: Mitochondrion inner membrane; Multi-pass membrane protein

Secondary accessions: B2RBL8 O95787 Q53GM0

Alternative splicing: 2 isoforms: Q9NUT2-1 Q9NUT2-2

REFSEQ proteins: NP_009119.2

ENSEMBL proteins:

ENSP00000297504 ENSP00000351717 ENSP00000353867 ENSP00000348353

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (ABCB8)
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5/7 Gene Ontology (GO) cellular component terms (links to tree view) (see all 7 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005624	membrane fraction	TAS	9878413
GO:0005739	mitochondrion	IEA	--
GO:0005740	mitochondrial envelope	TAS	9878413
GO:0005743	mitochondrial inner membrane	IEA	--
GO:0016020	membrane	IEA	--

About this table

Antibodies for ABCB8:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (ABCB8), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for ABCB8

Assays for ABCB8:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q9NUT2

ProtoNet protein and cluster: Q9NUT2

UniProtKB/Swiss-Prot: ABCB8_HUMAN, Q9NUT2

Similarity: Belongs to the ABC transporter family. Multidrug resistance exporter (TC 3.A.1.201)

subfamily

Similarity: Contains 1 ABC transmembrane type-1 domain

Similarity: Contains 1 ABC transporter domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ABCB8)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ABCB8)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_007188

Applied Biosystems Silencer® siRNAs for ABCB8

Sigma-Aldrich siRNA and siRNA Panels for ABCB8

Sigma-Aldrich shRNA for ABCB8

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_007188
Myc/DDK tagged cDNA clone in CMV expression vector: NM_007188
untagged cDNA clone in CMV expression vector: NM_007188

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_007188

Genatlas biochemistry entry for ABCB8:

ATP binding cassette superfamily,subfamily B (MDR/TAP),member 8,ubiquitously expressed,located in

mitochondrial inner membrane

5 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0005215	transporter activity	TAS	9878413
GO:0005524	ATP binding	TAS	9878413
GO:0016887	ATPase activity	IEA	--
GO:0042626	ATPase activity, coupled to transmembrane movement of substances	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

5/16 Interacting proteins for ABCB8 (Q9NUT2² ENSP00000297504³) via UniProtKB, MINT, and/or STRING (see all 16 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
C4orf14	Q8NC60²	MINT-65638
SAT1	P21673²	MINT-63584
ABCF2	ENSP00000222388³	STRING (score=.963)
ABCB10	ENSP00000355637³	STRING (score=.94)
ABCB9	ENSP00000280560³	STRING (score=.93)

About this table

1 Gene Ontology (GO) biological process term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006810	transport	TAS	9878413

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for ABCB8

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ABCB8)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ABCB8)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_007188

Sigma-Aldrich siRNA and siRNA Panels for ABCB8

Sigma-Aldrich shRNA for ABCB8

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_007188

REFSEQ mRNAs for ABCB8 gene:

NM_007188.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_007188

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_007188
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_007188
                                 untagged cDNA clone in CMV expression vector: NM_007188

Additional cDNA sequence:

AF047690.1 AF086382.1 AK002018.1 AK024401.1 AK094005.1 AK094636.1 AK222911.1 AK294344.1

AK310796.1 AK314721.1 AL117497.1 BC141814.1 BC141836.1 BC151235.1 CR592221.1 CR595185.1

CR599833.1 CR610778.1 CR616094.1 U66688.1

22 DOTS entries:

DT.100795794 DT.310230 DT.101984506 DT.112092 DT.100795799 DT.91750226 DT.100795798 DT.100028068

DT.121101666 DT.95376252 DT.100795797 DT.92426830 DT.121101698 DT.100795791 DT.102831874 DT.121101754

DT.102831873 DT.121101669 DT.121101676 DT.121101685 DT.121101688 DT.92051112

24/204 AceView cDNA sequences (see all 204 ):

CR595185 BM976848 BM703142 BM704396 BQ223720 CA944727 AA309016 BE384965

CA395398 BU155892 BQ718758 AK126885 AK094636 BU625433 AF195024 CR616094

BQ676865 AW960651 BC030282 AF195025 AK128129 BM552265 CA454776 CR592221

highest scoring ESTs for ABCB8:

U66688 AA116009 AA190206 AA309016 AA719140 AF047690 AI083583 AI168486 AI420480 AI656922

Unigene Cluster for ABCB8:

ATP-binding cassette, sub-family B (MDR/TAP), member 8

Hs.647118 [show with all ESTs]

Unigene Representative Sequence: NM_007188

GeneLoc Exon Structure

5/27 Alternative Splicing Database (ASD) splice patterns (SP) for ABCB8 (see all 27 )

ExUns:	1a	·	1b	·	1c	·	1d	^	2a	·	2b	·	2c	·	2d	·	2e	·	2f	^	3a	·	3b	^	4a	·	4b	·	4c	·	4d	^	5a	·	5b	·	5c	·	5d	·	5e	^	6a	·	6b	^	7a	·	7b	·	7c	^
SP1:									-		-		-		-		-		-				-		-		-		-		-		-		-
SP2:									-		-		-		-		-		-		-		-		-		-		-		-		-		-						-
SP3:									-		-		-		-		-		-		-		-		-		-		-		-		-		-
SP4:									-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-
SP5:

ExUns:	8a	·	8b	^	9a	·	9b	^	10a	·	10b	^	11	^	12	^	13	^	14a	·	14b	·	14c	^	15a	·	15b	^	16a	·	16b	^	17	^	18	^	19	^	20	^	21a	·	21b	^	22	^	23a	·	23b	·	23c	^
SP1:																			-		-		-		-						-
SP2:																			-		-		-		-						-
SP3:																			-		-		-		-						-
SP4:																			-		-		-		-						-
SP5:

ExUns:	24	^	25	^	26	^	27a	·	27b	^	28a	·	28b	^	29	^	30	^	31	^	32a	·	32b	·	32c
SP1:
SP2:
SP3:
SP4:
SP5:																					-

About this scheme

ECgene alternative splicing isoforms for ABCB8

4 Ensembl transcripts including schematic representations:

ENST00000297504 ENST00000358849 ENST00000360651 ENST00000356058

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

ABCB8 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ABCB8

¹ / ² / ³

6 probe-sets matching ABCB8 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
57629_at²^{, 3}	U95-C	1	1.00	1.00	0.99	1.35	AA917637	0.40	0.50	0.45	1
37496_at²^{, 3}	U95-A	1	1.00	1.00	-0.41	0.66	U66688	1.00	0.90	0.95	1
206317_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_007188	0.60	0.83	0.73	1
229539_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AW665395	0.20	0.50	0.38	1
206317_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
229539_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks ABCB8 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.647118
Expression variation in blood from EXPOLDB for ABCB8
UniProtKB/Swiss-Prot: ABCB8_HUMAN, Q9NUT2
Tissue specificity: Ubiquitous

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ABCB8 gene from 5/11 species (see all 11 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ABCB8¹	--	ATP-binding cassette, sub-family B (MDR/TAP), member more	86.12(n) 87.52(a)	482800 XM_539916.2 XP_539916.2
chimpanzee (Pan troglodytes)	ABCB8¹	--	ATP-binding cassette, sub-family B (MDR/TAP), member more	99.31(n) 99.4(a)	463892 XM_519524.2 XP_519524.2
rat (Rattus norvegicus)	Abcb8¹	--	ATP-binding cassette, sub-family B (MDR/TAP), member more	82.96(n) 83.33(a)	362302 NM_001007796.1 NP_001007797.1
mouse (Mus musculus)	Abcb8^{1, 5}	5⁵	ATP-binding cassette, sub-family B (MDR/TAP), member more^{1, 5}	82.89(n)¹ 84.38(a)¹	74610¹ NM_029020.2¹ NP_083296.2¹ AA409895⁵ AA544556⁵ (see all 32)
zebrafish (Danio rerio)	Dr.18475²	--	Transcribed sequence with moderate similarity to protein more	74.02(n)	BG303035.1

About this table Species with no ortholog for ABCB8

ENSEMBL Gene Tree for ABCB8

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for ABCB8 gene

TAP2² ENSG00000168394²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/99 NCBI SNPs in ABCB8 are shown (see all 99 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 37)

AB	SNP ID	Valid	Chr 7 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs17545756^1,2	C,F,H	150363745(+)	`TGTCTC/TGCCAG`	1	R/C	mis¹ ese³		11		NA EU EA WA	978
	rs4148844^1,2	C,F,H	150361932(+)	`TAGCCG/ATCGTG`	1	I/V	mis¹ ese³		8		EU EA WA	816
	rs891506^1,2	C,F,H	150373633(+)	`GTTCCC/ACGAGA`	1	--	ut3¹		4		EA NA WA	178
--	rs2116023^1,2	A,C	150355736(+)	`gagacA/Gtttgt`	1	--	ng5¹		0	--	--	--	--
--	rs2373927^1,2	A,C	150355344(-)	`cttccG/Tcagtg`	1	--	ng5¹		0	--	--	--	--
--	rs4148854^1,2	C	150374753(+)	`GTGATA/GCAGTG`	1	--	ut3¹		0	--	--	--	--
--	rs4148853^1,2	C	150373918(+)	`ACCCCA/GGGACC`	1	--	ut3¹		0	--	--	--	--
	rs2303927^1,2	H	150370042(+)	`AGCTTC/GCGATG`	1	S/C	mis¹ ese³		5		EA EU WA	1910
	rs2303926^1,2	A,C,F	150363958(+)	`GTGCGT/AGCCTT`	1	R/R	syn¹ ese³		8		EA NA	1972
--	rs4148850^1,2	A,C,F,H	150369557(+)	`AGCCTA/GTAGTG`	1	--	int¹		4		EU EA WA	412

About this table

HapMap Linkage Disequilibrium images for ABCB8 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 605464

Human Genome Epidemiology Navigator: ABCB8 (1 document)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/14 PubMed articles for ABCB8 gene (see all 14 ):

Identification and characterization of a mammalian mitochondrial ATP- binding cassette membrane protein. (PubMed id 9878413)^{1, 3, 4} Hogue D.L.... Ling V. (1999)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{3, 4} Ota T....Sugano S. (2004)
Three hundred twenty-six genetic variations in genes encoding nine members of ATP-binding cassette, subfamily B (ABCB/MDR/TAP), in the Japanese population. (PubMed id 11829140)^{3, 4} Saito S.... Nakamura Y. (2002)
Characterization of the human ABC superfamily: isolation and mapping of 21 new genes using the expressed sequence tags database. (PubMed id 8894702)^{2, 3} Allikmets R....Dean M. (1996)
ABCB8 mediates doxorubicin resistance in melanoma cells by protecting the mitochondrial genome. (PubMed id 19147539)³ Elliott A.M. and Al-Hajj M.A. (2009)
Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects. (PubMed id 19343046)³ Saito A....Kamatani N. (2009)
The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)⁴ Sjoeblom T.... Velculescu V.E. (2006)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)³ Kimura K.... Sugano S. (2006)
A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)³ Stelzl U....Wanker E.E. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)⁴ Gerhard D.S....Malek J. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 11194	HGNC: 49	AceView: ACCN3andABCB8	Ensembl:ENSG00000197150	euGenes: HUgn11194
ECgene: ABCB8	H-InvDB: ABCB8

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for ABCB8
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for ABCB8:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ABCB8-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ABCB8		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for ABCB8		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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Search Tocris compounds for ABCB8

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Search Novus for antibodies for ABCB8

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ABCB8 Gene

protein-coding GIFtS: 57

Aliases &
Descriptions
for ABCB8

Summaries
for ABCB8

Genomic Location
for ABCB8

Proteins
for ABCB8

Protein Domains/
Families
for ABCB8

Gene Function
for ABCB8

Pathways & Interactions
for ABCB8

Drugs & Compounds
for ABCB8

Transcripts
for ABCB8

Expression
for ABCB8

Orthologs
for ABCB8

Paralogs
for ABCB8

SNPs/Variants
for ABCB8

Disorders & Mutations
for ABCB8

Medical News
for ABCB8

Publications
for ABCB8

Search for ABCB8

Genome Databases showing ABCB8

Other Databases showing ABCB8

Specialized Databases showing ABCB8

Licensable Technologies
for ABCB8

Services
for ABCB8

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ABCB8 Gene

protein-coding GIFtS: 57

Aliases & Descriptionsfor ABCB8

Summariesfor ABCB8

Genomic Locationfor ABCB8

Proteinsfor ABCB8

Protein Domains/Familiesfor ABCB8

Gene Functionfor ABCB8

Pathways & Interactionsfor ABCB8

Drugs & Compoundsfor ABCB8

Transcriptsfor ABCB8

Expression for ABCB8

Orthologsfor ABCB8

Paralogsfor ABCB8

SNPs/Variantsfor ABCB8

Disorders & Mutationsfor ABCB8

Medical Newsfor ABCB8

Publicationsfor ABCB8

Search for ABCB8

Genome Databases showing ABCB8

Other Databases showing ABCB8

Specialized Databases showing ABCB8

Licensable Technologiesfor ABCB8

Servicesfor ABCB8

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ABCB8

Summaries
for ABCB8

Genomic Location
for ABCB8

Proteins
for ABCB8

Protein Domains/
Families
for ABCB8

Gene Function
for ABCB8

Pathways & Interactions
for ABCB8

Drugs & Compounds
for ABCB8

Transcripts
for ABCB8

Expression
for ABCB8

Orthologs
for ABCB8

Paralogs
for ABCB8

SNPs/Variants
for ABCB8

Disorders & Mutations
for ABCB8

Medical News
for ABCB8

Publications
for ABCB8

Licensable Technologies
for ABCB8

Services
for ABCB8