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ABCB6 Gene

protein-coding GIFtS: 60

GC02M219782

ATP-binding cassette, sub-family B (MDR/TAP), member 6
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
ABC ^²
ABC14 ^²
EST45597 ^¹, ²
FLJ22414 ^²
MTABC3 ^¹, ², ³, ⁵
PRP ^², ³
UMAT ^³
umat ^¹, ²

Descriptions
ATP-binding cassette half-transporter ^²
ATP-binding cassette, sub-family B (MDR/TAP), member 6 ^²
ATP-binding cassette, sub-family B, member 6 ^²
Mitochondrial ABC transporter 3 ^³
Mt-ABC transporter 3 ^³
P-glycoprotein-related protein ^³
Ubiquitously-expressed mammalian ABC half transporter ^³

External Ids
HGNC: 47¹
Entrez Gene: 10058²
UniProtKB: Q9NP58³
Ensembl: ENSG00000115657⁷

Search outside databases for aliases for ABCB6 gene

Previous GC identifers: GC02M218090 GC02M218795 GC02M220038 GC02M220277 GC02M219899

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for ABCB6:

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding

cassette (ABC) transporters. ABC proteins transport various molecules across extra- and

intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP,

MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the

MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This

half-transporter likely plays a role in mitochondrial function. Localized to 2q26, this gene is

considered a candidate gene for lethal neonatal metabolic syndrome, a disorder of mitochondrial

function. [provided by RefSeq]

UniProtKB/Swiss-Prot: ABCB6_HUMAN, Q9NP58

Function: Binds heme and porphyrins and functions in their ATP-dependent uptake into the

mitochondria. Plays a crucial role in heme synthesis

Gene Wiki entry for ABCB6

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ABCB6 gene

Entrez Gene cytogenetic band: 2q36 Ensembl cytogenetic band: 2q35 HGNC cytogenetic band: 2q36

ABCB6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02M219782: (about GC identifiers)

Start:	219,782,738 bp from pter
End:	219,791,917 bp from pter
Size:	9,180 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000002.10 NT_005403.16

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: ABCB6_HUMAN, Q9NP58 (See protein sequence)

Recommended Name: ATP-binding cassette sub-family B member 6, mitochondrial

Size: 842 amino acids; 93886 Da

Subunit: Homodimer

Subcellular location: Mitochondrion outer membrane; Multi-pass membrane protein

Developmental stage: Highly expressed in fetal liver

Miscellaneous: Depletion of Abcb6 by RNAi abrogates heme biosynthesis. Overexpression enhances

porphyrin biosynthesis

Sequence caution: Sequence=AAH43423.1; Type=Miscellaneous discrepancy; Note=Intron retention;

Sequence=BAD18782.1; Type=Erroneous termination; Positions=168; Note=Translated as Trp;

Sequence=BAD92291.1; Type=Miscellaneous discrepancy; Note=Chimeric cDNA;

Secondary accessions: O75542 Q49A66 Q59GQ5 Q6ZME6 Q96ME8 Q9HAQ6 Q9HAQ7

Alternative splicing: 2 isoforms: Q9NP58-1 Q9NP58-4

REFSEQ proteins: NP_005680.1

ENSEMBL proteins:

ENSP00000265316 ENSP00000295750

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (ABCB6)
	Human Recombinant Proteins from Abnova (ABCB6)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5/6 Gene Ontology (GO) cellular component terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005739	mitochondrion	IDA	10837493
GO:0005740	mitochondrial envelope	IDA	10837493
GO:0005741	mitochondrial outer membrane	IEA	--
GO:0016020	membrane	IEA	--
GO:0016021	integral to membrane	IEA	--

About this table

Antibodies for ABCB6:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (ABCB6), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (ABCB6)
	Novus Biologicals Antibody for ABCB6

Assays for ABCB6:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q9NP58

ProtoNet protein and cluster: Q9NP58

UniProtKB/Swiss-Prot: ABCB6_HUMAN, Q9NP58

Similarity: Belongs to the ABC transporter family. Heavy Metal importer (TC 3.A.1.210) subfamily

Similarity: Contains 1 ABC transmembrane type-1 domain

Similarity: Contains 1 ABC transporter domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ABCB6)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ABCB6)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005689

Applied Biosystems Silencer® siRNAs for ABCB6

Sigma-Aldrich siRNA and siRNA Panels for ABCB6

Sigma-Aldrich shRNA for ABCB6

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_005689
Myc/DDK tagged cDNA clone in CMV expression vector: NM_005689
untagged cDNA clone in CMV expression vector: NM_005689

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_005689

UniProtKB/Swiss-Prot: ABCB6_HUMAN, Q9NP58

Function: Binds heme and porphyrins and functions in their ATP-dependent uptake into the

mitochondria. Plays a crucial role in heme synthesis

Induction: Up-regulated by cellular porphyrins (at protein level)

Genatlas biochemistry entry for ABCB6:

ATP binding cassette superfamily,subfamily B (MDR/TAP),member 6

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0005524	ATP binding	IDA	10837493
GO:0016887	ATPase activity	IEA	--
GO:0042626	ATPase activity, coupled to transmembrane movement of substances	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for ABCB6

2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006810	transport	IDA	10837493
GO:0006879	cellular iron ion homeostasis	NAS	11977179

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for ABCB6
3 Novoseek chemical compound relationships for ABCB6 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
iron	13.28	6	10837493 (3), 11977179 (2)
atp	10.23	3	11955620 (2), 16618113 (1)
lipid	0.00	2	13678819 (1), 16162093 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ABCB6)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ABCB6)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005689

Sigma-Aldrich siRNA and siRNA Panels for ABCB6

Sigma-Aldrich shRNA for ABCB6

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_005689

REFSEQ mRNAs for ABCB6 gene:

NM_005689.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_005689

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_005689
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_005689
                                 untagged cDNA clone in CMV expression vector: NM_005689

Additional cDNA sequence:

AF070598.1 AF076775.1 AF308472.1 AJ289233.2 AK026067.1 AK057026.1 AK172812.1 AK303230.1

BC000559.2 BC043423.1 CR609962.1 U66673.1

17 DOTS entries:

DT.87046556 DT.100702442 DT.100836568 DT.121017494 DT.100776774 DT.101985085 DT.211669 DT.100650765

DT.95178118 DT.100644208 DT.100776777 DT.92438261 DT.100776776 DT.100776779 DT.121017511 DT.95178121

DT.91673332

24/190 AceView cDNA sequences (see all 190 ):

BM678300 AW205829 W79936 CA441997 AW450832 BM970614 BU628545 BU753914

BU739042 CB156337 AI201831 CF529046 BM676624 BE743584 AF076775 CA429310

BQ006982 BM720321 AF070598 BX348255 BM701547 BE262425 BG519710 BC043423

highest scoring ESTs for ABCB6:

AF070598 AF308472 AJ289233 AK057026 AL530678 BC000559 BE260438 BE261802 BE314828 BE560171

Unigene Cluster for ABCB6:

ATP-binding cassette, sub-family B (MDR/TAP), member 6

Hs.107911 [show with all ESTs]

Unigene Representative Sequence: BC043423

GeneLoc Exon Structure

5/10 Alternative Splicing Database (ASD) splice patterns (SP) for ABCB6 (see all 10 )

ExUns:	1a	·	1b	·	1c	^	2	^	3a	·	3b	^	4	^	5a	·	5b	^	6a	·	6b	·	6c	·	6d	^	7a	·	7b	^	8a	·	8b	^	9a	·	9b	^	10a	·	10b	^	11	^	12a	·	12b	^	13	^	14	^
SP1:															-				-		-						-																		-
SP2:							-								-				-		-						-																		-
SP3:																																													-
SP4:
SP5:									-		-				-				-		-

ExUns:	15a	·	15b	^	16a	·	16b	^	17	^	18	^	19a	·	19b
SP1:					-
SP2:					-
SP3:					-
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for ABCB6

2 Ensembl transcripts including schematic representations:

ENST00000265316 ENST00000295750

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

ABCB6 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ABCB6

¹ / ² / ³

3 probe-sets matching ABCB6 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
39805_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	AF070598	0.80	0.88	0.84	1
203192_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_005689	0.60	0.83	0.73	1
203192_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks ABCB6 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GAACGGTGAC

SOURCE GeneReport for Unigene cluster: Hs.107911
Expression variation in blood from EXPOLDB for ABCB6
UniProtKB/Swiss-Prot: ABCB6_HUMAN, Q9NP58
Tissue specificity: Widely expressed. Highest expression in heart and skeletal muscles

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ABCB6 gene from 5/13 species (see all 13 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ABCB6¹	--	ATP-binding cassette, sub-family B (MDR/TAP), member more	89.61(n) 89.13(a)	478914 XM_536073.2 XP_536073.2
chimpanzee (Pan troglodytes)	ABCB6¹	--	ATP-binding cassette, sub-family B (MDR/TAP), member more	99.49(n) 99.64(a)	459959 XM_001161097.1 XP_001161097.1
cow (Bos taurus)	ABCB6¹	--	ATP-binding cassette, sub-family B (MDR/TAP), member more	88.52(n) 89.39(a)	783257 XM_001251071.1 XP_001251072.1
rat (Rattus norvegicus)	Abcb6¹	--	ATP-binding cassette, sub-family B (MDR/TAP), member more	86.75(n) 88.38(a)	140669 NM_080582.1 NP_542149.1
mouse (Mus musculus)	Abcb6^{1, 5}	1⁵	ATP-binding cassette, sub-family B (MDR/TAP), member more^{1, 5}	86.87(n)¹ 89.38(a)¹	74104¹ NM_023732.2¹ NP_076221.1¹ AF045562⁵ AI843102⁵ (see all 24)

About this table Species with no ortholog for ABCB6

ENSEMBL Gene Tree for ABCB6

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for ABCB6 gene

ABCB7²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/44 NCBI SNPs in ABCB6 are shown (see all 44 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 47)

AB	SNP ID	Valid	Chr 2 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs1109867^1,2	A,C,F,H	219791697(+)	`GGACTT/GGTCAC`	1	--	ut5¹ ese³		12	MN EU EA WA NA	1074
	rs13402964^1,2	C,F,H	219785378(+)	`CTATTC/TGGATG`	1	R/Q	mis¹ ese³		8	EU EA WA	832
	rs13018440^1,2	H	219789423(+)	`AGTCAG/CCAAGT`	1	V/L	mis¹ ese³		4	EU EA WA	402
	rs13018427^1,2	H	219789400(+)	`AGAGAG/TTTCCA`	1	N/K	mis¹		4	EU EA WA	406
	rs13018099^1,2	H	219789372(+)	`GAAGAC/AGTAAC`	1	F/V	mis¹ ese³		4	EU EA WA	406
	rs13018426^1,2	H	219789392(+)	`TCCAGG/CCCAGA`	1	G/A	mis¹		4	EU EA WA	406
	rs1109866^1,2	A,C,F,H	219791523(+)	`GTCCCT/CAGAGC`	1	L/L	syn¹		11	MN EU EA WA NA	980
--	rs6727770^1,2	H	219783686(+)	`TCCAGC/GAGAAT`	1	L/L	syn¹ ese³		4	EU EA WA	420
	rs2293080^1,2	C,F,H	219787025(+)	`TCTTGG/ACCCTG`	1	--	int¹		5	EA EU WA	1916
	rs9288542^1,2	C,H	219786307(+)	`CACCAC/TCCATG`	1	--	int¹		4	EU EA WA	418

About this table

HapMap Linkage Disequilibrium images for ABCB6 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 605452

4 Novoseek disease relationships for ABCB6 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
adrenoleukodystrophy	73.44	3	8876235 (1), 9587057 (1)
cystic fibrosis	28.73	1	12369999 (1)
breast cancer	25.01	3	14618629 (1), 11205902 (1), 12369999 (1)
cancer	3.80	2	16842198 (1), 16024622 (1)

About this table

Genetic Association Database: ABCB6
Human Genome Epidemiology Navigator: ABCB6 (2 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/42 PubMed articles for ABCB6 gene (see all 42 ):

ABCB6 (MTABC3) excluded as the causative gene for the growth retardation syndrome with aminoaciduria, cholestasis, iron overload, and lactacidosis. (PubMed id 11977179)^{1, 3, 6} Visapaa I....Peltonen L. (2002)
MTABC3, a novel mitochondrial ATP-binding cassette protein involved in iron homeostasis. (PubMed id 10837493)^{1, 3, 4} Mitsuhashi N.... Seino S. (2000)
Isolation of a genomic clone containing the promoter region of the human ATP binding cassette (ABC) transporter, ABCB6. (PubMed id 11955620)^{1, 3, 4} Emadi-Konjin H.-P....Furuya K.N. (2002)
Heteronuclear multidimensional NMR and homology modelling studies of the C-terminal nucleotide-binding domain of the human mitochondrial ABC transporter ABCB6. (PubMed id 16791740)^{3, 4} Kurashima-Ito K.... Ito Y. (2006)
Identification of a mammalian mitochondrial porphyrin transporter. (PubMed id 17006453)^{3, 4} Krishnamurthy P.C.... Schuetz J.D. (2006)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{3, 4} Ota T....Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Large-scale concatenation cDNA sequencing. (PubMed id 9110174)^{2, 3} Yu W....Gibbs R.A. (1997)
Characterization of the human ABC superfamily: isolation and mapping of 21 new genes using the expressed sequence tags database. (PubMed id 8894702)^{2, 3} Allikmets R....Dean M. (1996)
Human ABC transporter isoform B6 (ABCB6) localizes primarily in the Golgi apparatus. (PubMed id 18279659)^{1, 3} Tsuchida M....Sakaguchi M. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 10058	HGNC: 47	AceView: ABCB6	Ensembl:ENSG00000115657	euGenes: HUgn10058
ECgene: ABCB6	H-InvDB: ABCB6

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
ATLAS Chromosomes in Cancer entry for ABCB6	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for ABCB6
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for ABCB6:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ABCB6-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ABCB6		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for ABCB6		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

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	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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ABCB6 Gene

protein-coding GIFtS: 60

Aliases &
Descriptions
for ABCB6

Summaries
for ABCB6

Genomic Location
for ABCB6

Proteins
for ABCB6

Protein Domains/
Families
for ABCB6

Gene Function
for ABCB6

Pathways & Interactions
for ABCB6

Drugs & Compounds
for ABCB6

Transcripts
for ABCB6

Expression
for ABCB6

Orthologs
for ABCB6

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SNPs/Variants
for ABCB6

Disorders & Mutations
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Medical News
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Genome Databases showing ABCB6

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Services
for ABCB6

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ABCB6 Gene

protein-coding GIFtS: 60

Aliases & Descriptionsfor ABCB6

Summariesfor ABCB6

Genomic Locationfor ABCB6

Proteinsfor ABCB6

Protein Domains/Familiesfor ABCB6

Gene Functionfor ABCB6

Pathways & Interactionsfor ABCB6

Drugs & Compoundsfor ABCB6

Transcriptsfor ABCB6

Expression for ABCB6

Orthologsfor ABCB6

Paralogsfor ABCB6

SNPs/Variantsfor ABCB6

Disorders & Mutationsfor ABCB6

Medical Newsfor ABCB6

Publicationsfor ABCB6

Search for ABCB6

Genome Databases showing ABCB6

Other Databases showing ABCB6

Specialized Databases showing ABCB6

Licensable Technologiesfor ABCB6

Servicesfor ABCB6

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ABCB6

Summaries
for ABCB6

Genomic Location
for ABCB6

Proteins
for ABCB6

Protein Domains/
Families
for ABCB6

Gene Function
for ABCB6

Pathways & Interactions
for ABCB6

Drugs & Compounds
for ABCB6

Transcripts
for ABCB6

Expression
for ABCB6

Orthologs
for ABCB6

Paralogs
for ABCB6

SNPs/Variants
for ABCB6

Disorders & Mutations
for ABCB6

Medical News
for ABCB6

Publications
for ABCB6

Licensable Technologies
for ABCB6

Services
for ABCB6