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Aliases & Descriptions for ABCB5
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| ABCB5alpha 1, 2 | | ABCB5beta 1, 2 | | EST422562 1, 2 |
| | | Descriptions |
|---|
| ABCB5 P-gp 3 | | ATP-binding cassette protein 2 | | ATP-binding cassette, sub-family B (MDR/TAP), member 5 2 | | ATP-binding cassette, sub-family B, member 5 2 | | P-glycoprotein ABCB5 2, 3 |
|
| | Search outside databases for aliases for ABCB5 genePrevious GC identifers: GC07U990157 GC07P020328 GC07P020431 GC07P020412 GC07P020460 |
Summaries for ABCB5(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for ABCB5: ABCB5 belongs to the ATP-binding cassette (ABC) transporter superfamily of integral membrane proteins. These proteins participate in ATP-dependent transmembrane transport of structurally diverse molecules ranging from small ions, sugars, and peptides to more complex organic molecules (Chen et al., 2005 [PubMed 15760339]).[supplied by OMIM] UniProtKB/Swiss-Prot: ABCB5_HUMAN, Q2M3G0Function: Plasma membrane transporter able to mediate efflux from cells of the rhodamine dye and of the therapeutic drug doxorubicin. Responsible for the resistance to doxorubicin of a subset of malignant melanomas |
Genomic Location for ABCB5
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the ABCB5 gene 
Entrez Gene cytogenetic band: 7p15.3 Ensembl cytogenetic band: 7p15.3 HGNC cytogenetic band: 7p14ABCB5 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07P020653:
(about GC identifiers)
Start:
|
20,621,355 bp from pter |
End:
|
20,763,157 bp from pter |
Size:
|
141,803 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr7+,CRA_TCAG 20,738,553-20,846,586 |
RefSeq DNA sequence:- NC_000007.12 NT_007819.16 NT_079592.2
| Proteins for ABCB5
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: ABCB5_HUMAN, Q2M3G0 (See
protein sequence)Recommended Name: ATP-binding cassette sub-family B member 5 Size: 812 amino acids; 89831 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Miscellaneous: Depletion of ABCB5 by RNAi increases the sensitivity to several drugs of a subset of melanoma cells
Caution: Was named ABCB1 by some authors
Secondary accessions: A4D131 Q2M3I5 Q5I5Q7 Q5I5Q8 Q6KG50 Q6XFQ5 Q8IXA1Alternative splicing: 2 isoforms: Q2M3G0-1 Q2M3G0-2 REFSEQ proteins: NP_848654.3
ENSEMBL proteins: ENSP00000383899 ENSP00000258738 ENSP00000376217 ENSP00000385417 ENSP00000384881
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
2 Gene Ontology (GO) cellular component terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005886 | plasma membrane |
IEA | -- | | GO:0016021 | integral to membrane |
IEA | -- | About this table
Antibodies for ABCB5: Assays for ABCB5: | Protein
Domains/ Families for ABCB5(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q2M3G0
ProtoNet protein and cluster: Q2M3G0 UniProtKB/Swiss-Prot: ABCB5_HUMAN, Q2M3G0Similarity: Belongs to the ABC transporter family. Multidrug resistance exporter (TC 3.A.1.201) subfamilySimilarity: Contains 1 ABC transmembrane type-1 domainSimilarity: Contains 2 ABC transporter domains | Gene Function for ABCB5
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_178559
Applied Biosystems Silencer® siRNAs for ABCB5
Sigma-Aldrich siRNA and siRNA Panels for ABCB5  Sigma-Aldrich shRNA for ABCB5  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_178559                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_178559                                  untagged cDNA clones in CMV expression vector (see all 2): NM_178559 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_178559
UniProtKB/Swiss-Prot: ABCB5_HUMAN, Q2M3G0Function: Plasma membrane transporter able to mediate efflux from cells of the rhodamine dye and of the therapeutic drug doxorubicin. Responsible for the resistance to doxorubicin of a subset of malignant melanomasGenatlas biochemistry entry for ABCB5:ATP binding cassette superfamily,subfamily B (MDR/TAP),member 5,ubiquitously expressed4 Gene Ontology (GO) molecular function terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000166 | nucleotide binding |
IEA | -- | | GO:0005524 | ATP binding |
IEA | -- | | GO:0016887 | ATPase activity |
IEA | -- | | GO:0042626 | ATPase activity, coupled to transmembrane movement of substances |
IEA | -- | About this table | Pathways & Interactions for ABCB5
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
1 Gene Ontology (GO) biological process term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006810 | transport |
IEA | -- | About this table
|
Drugs & Compounds for ABCB5(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for ABCB5
|
Transcripts for ABCB5(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_178559
Sigma-Aldrich siRNA and siRNA Panels for ABCB5  Sigma-Aldrich shRNA for ABCB5  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_178559 REFSEQ mRNAs for ABCB5 gene: NM_178559.4
Applied Biosystems TaqMan ® Gene Expression Assays: NM_178559               OriGene GFP tagged cDNA clone in CMV expression vector: NM_178559                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_178559                                  untagged cDNA clones in CMV expression vector (see all 2): NM_178559  Additional cDNA sequence: AB353947.1 AF319622.1 AF399931.1 AK127141.1 AY090613.1 AY230001.1 AY234788.1 AY785909.1 AY851364.1 AY851365.1 BC044248.1 BC104894.1 BC104920.1 BC110370.1 BX537763.1 CR595059.1 U66692.1 9 DOTS entries: DT.99941473 DT.320703 DT.108191 DT.121059155 DT.121059165 DT.101958082 DT.101970870 DT.201506 DT.40307081 24/29 AceView cDNA sequences (see all 29
):H98200 AK127141 AL040762 AY234788 AY090613 AA243820 AF399931 BX452500 NM_178559 CR595059 AI289916 N43802 BX537763 BM926413 AF319622 AL040717 BM471690 BM013981 AL040763 BC044248 BX463401 BM016204 U66692 N24315
highest scoring ESTs for ABCB5:AK127141 AF319622 AF399931 AY090613 AY234788 AA243820 AI289916 AL040762 AL040763 BC044248 Unigene Cluster for ABCB5: ATP-binding cassette, sub-family B (MDR/TAP), member 5 Hs.658821 [show with all ESTs]Unigene Representative Sequence: AY230001
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for ABCB5
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 | |
| SP1: | |   | |   | |   | |   | |   | |   | |   | - |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for ABCB5
5 Ensembl transcripts including schematic representations: ENST00000406935
ENST00000258738
ENST00000392419
ENST00000402177
ENST00000404938
|
Expression for ABCB5
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| ABCB5 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for ABCB5
1 / 2 / 3 6 probe-sets matching ABCB5 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: --
SOURCE GeneReport for Unigene cluster: Hs.658821 UniProtKB/Swiss-Prot: ABCB5_HUMAN, Q2M3G0Tissue specificity: Expressed by CD133-expressing progenitor cells among epidermal melanocytes (at protein level). Widely expressed with specific expression in pigment cells. Also expressed in several malignant tissues |
Orthologs for ABCB5
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for ABCB5 gene from 5/6 species (see all 6
)
| Organism |
Gene |
Locus |
Description |
Human Similarity |
NCBI accessions |
dog (Canis familiaris) |
ABCB51 |
-- |
ATP-binding cassette, sub-family B (MDR/TAP), member more |
87.31(n) 85.04(a) |
482344 XM_539461.2 XP_539461.2 |
chimpanzee (Pan troglodytes) |
ABCB51 |
-- |
ATP-binding cassette, sub-family B (MDR/TAP), member more |
98.77(n) 98.4(a) |
743269 XM_001152831.1 XP_001152831.1 |
rat (Rattus norvegicus) |
Abcb51 |
-- |
ATP-binding cassette, sub-family B (MDR/TAP), member more |
80.79(n) 78.93(a) |
314537 XM_234725.4 XP_234725.4 |
mouse (Mus musculus) |
Abcb51, 5 |
125
|
ATP-binding cassette, sub-family B (MDR/TAP), member more1, 5 |
81.73(n)1 78.77(a)1 |
777061 XM_001002680.21 XP_001002680.21 AK0203185 AK1398325 (see all 7) |
thale cress (Arabidopsis thaliana) |
PGP141 |
-- |
PGP14 (P-GLYCOPROTEIN 14); ATPase, coupled to transmembrane more |
49.13(n) 41.27(a) |
839694 NM_102566.2 NP_174122.1 |
About this table Species with no ortholog for ABCB5
ENSEMBL Gene Tree for ABCB5 | Paralogs for ABCB5(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for ABCB5 gene
- ABCB12 ABCB42 ABCB112
|
SNPs/Variants for ABCB5(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for ABCB5 (up to first 250kb)
|
Disorders & Mutations for ABCB5
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 611785
|
Medical News for ABCB5(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for ABCB5 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/12 PubMed articles for ABCB5 gene (see all 12
):- Regulation of progenitor cell fusion by ABCB5 P-glycoprotein, a novel human ATP-binding cassette transporter. (PubMed id 12960149)2, 3, 4 Frank N.Y....Frank M.H. (2003)
- Principal expression of two mRNA isoforms (ABCB 5alpha and ABCB 5beta) of the ATP-binding cassette transporter gene ABCB 5 in melanoma cells and melanocytes. (PubMed id 15760339)3, 4 Chen K.G....Gottesman M.M. (2005)
- ABCB5-mediated doxorubicin transport and chemoresistance in human malignant melanoma. (PubMed id 15899824)3, 4 Frank N.Y.... Frank M.H. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Membrane transporters and channels: role of the transportome in cancer chemosensitivity and chemoresistance. (PubMed id 15205344)3, 4 Huang Y.... Sadee W. (2004)
- Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)3, 4 Scherer S.W....Tsui L.C. (2003)
- Characterization of the human ABC superfamily: isolation and mapping of 21 new genes using the expressed sequence tags database. (PubMed id 8894702)2, 3 Allikmets R....Dean M. (1996)
- Identification of cells initiating human melanomas. (PubMed id 18202660)3 Schatton T....Frank M.H. (2008)
- The Role of heat shock protein 27 in extravillous trophoblast differentiation. (PubMed id 17661346)3 Matalon S.T....Lishner M. (2008)
- The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)4 Sjoeblom T.... Velculescu V.E. (2006)
|
Search for ABCB5
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing ABCB5
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing ABCB5
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ABCB5(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for ABCB5(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for ABCB5:

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Incremental update: 13 Oct 2009
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