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ABCB4 Gene

protein-coding GIFtS: 62

GC07M086869

ATP-binding cassette, sub-family B (MDR/TAP), member 4
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: PGY3, MDR3)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
ABC21 ^²
EC 3.6.3.44 ^³
GBD1 ^¹, ²
MDR2 ^¹, ²
MDR2/3 ^²
MDR3 ^², ³, ⁵
OTTHUMP00000025014 ^²
PFIC-3 ^¹, ²
PGY3 ^², ³, ⁵

Descriptions
ATP-binding cassette sub-family B member 4 ^³
ATP-binding cassette, sub-family B (MDR/TAP), member 4 ^²
ATP-binding cassette, subfamily B, member 4 ^²
P glycoprotein 3/multiple drug resistance 3 ^²
P-glycoprotein 3 ^³
P-glycoprotein-3/multiple drug resistance-3 ^²
multidrug resistance protein 3 ^²
multiple drug resistance 3 ^²

External Ids
HGNC: 45¹
Entrez Gene: 5244²
UniProtKB: P21439³
Ensembl: ENSG00000005471⁷

Search outside databases for aliases for ABCB4 gene

Previous GC identifers: GC07M085566 GC07M086629 GC07M086643 GC07M086676

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for ABCB4:

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding

cassette (ABC) transporters. ABC proteins transport various molecules across extra- and

intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP,

MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the

MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This gene

encodes a full transporter and member of the p-glycoprotein family of membrane proteins with

phosphatidylcholine as its substrate. The function of this protein has not yet been determined;

however, it may involve transport of phospholipids from liver hepatocytes into bile. Alternative

splicing of this gene results in several products of undetermined function. [provided by RefSeq]

UniProtKB/Swiss-Prot: MDR3_HUMAN, P21439

Function: Mediates ATP-dependent export of organic anions and drugs from the cytoplasm. Hydrolyzes

ATP with low efficiency. Human MDR3 is not capable of conferring drug resistance. Mediates the

translocation of phosphatidylcholine across the canalicular membrane of the hepatocyte

Gene Wiki entry for ABCB4

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ABCB4 gene

Entrez Gene cytogenetic band: 7q21.1 Ensembl cytogenetic band: 7q21.12 HGNC cytogenetic band: 7q21

ABCB4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 7 GeneLoc Exon Structure

GeneLoc location for GC07M086869: (about GC identifiers)

Start:	86,869,297 bp from pter
End:	86,942,991 bp from pter
Size:	73,695 bases
Orientation:	minus strand

1 alternative location:

Chr7-,CRA_TCAG 86,362,871-86,436,531

RefSeq DNA sequence:

NC_000007.12 NT_007933.14 NT_079595.2

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: MDR3_HUMAN, P21439 (See protein sequence)

Recommended Name: Multidrug resistance protein 3

Size: 1286 amino acids; 141523 Da

Subcellular location: Cell membrane; Multi-pass membrane protein

Secondary accessions: A0A2V7 Q14813

Alternative splicing: 2 isoforms: P21439-1 P21439-2

REFSEQ proteins (3 alternative transcripts):

NP_000434.1 NP_061337.1 NP_061338.1

ENSEMBL proteins:

ENSP00000351172 ENSP00000352135 ENSP00000265723

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (ABCB4)
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5/6 Gene Ontology (GO) cellular component terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000139	Golgi membrane	IEA	--
GO:0005624	membrane fraction	TAS	7912658
GO:0005887	integral to plasma membrane	TAS	7912658
GO:0016020	membrane	IEA	--
GO:0016324	apical plasma membrane	IEA	--

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Antibodies for ABCB4:

	Invitrogen Antibodies for ABCB4
	Millipore Mono- and Polyclonal Antibodies for the study of ABCB4
	Sigma-Aldrich Antibodies for ABCB4
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (ABCB4), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (ABCB4)
	Search Novus for antibodies for ABCB4

Assays for ABCB4:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P21439

ProtoNet protein and cluster: P21439

UniProtKB/Swiss-Prot: MDR3_HUMAN, P21439

Similarity: Belongs to the ABC transporter family. Multidrug resistance exporter (TC 3.A.1.201)

subfamily

Similarity: Contains 2 ABC transmembrane type-1 domains

Similarity: Contains 2 ABC transporter domains

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ABCB4)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ABCB4)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_000443

Applied Biosystems Silencer® siRNAs for ABCB4

Sigma-Aldrich siRNA and siRNA Panels for ABCB4

Sigma-Aldrich shRNA for ABCB4

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_000443
Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_000443
untagged cDNA clones in CMV expression vector (see all 3): NM_000443

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_018849

UniProtKB/Swiss-Prot: MDR3_HUMAN, P21439

Function: Mediates ATP-dependent export of organic anions and drugs from the cytoplasm. Hydrolyzes

ATP with low efficiency. Human MDR3 is not capable of conferring drug resistance. Mediates the

translocation of phosphatidylcholine across the canalicular membrane of the hepatocyte

Catalytic activity: ATP + H(2)O + xenobiotic(In) = ADP + phosphate + xenobiotic(Out)

Enzyme Number (IUBMB): EC 3.6.3.44

Genatlas biochemistry entry for ABCB4:

ATP binding cassette superfamily,subfamily B (MDR/TAP),member 4,involved in phosphatidylcholine

translocation into the bile

5 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Abcb4):

digestive/alimentary

endocrine/exocrine gland

homeostasis/metabolism

immune system

liver/biliary system

5/6 Gene Ontology (GO) molecular function terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0005515	protein binding	IEA	--
GO:0005524	ATP binding	IEA	--
GO:0008559	xenobiotic-transporting ATPase activity	IEA	--
GO:0016787	hydrolase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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2 Sigma-Aldrich "Your Favorite Gene" Pathways for ABCB4 (Your Favorite Gene powered by Ingenuity)

Hepatic Cholestasis
FXR/RXR Activation

GeneDecks ABCB4 for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for ABCB4

5/13 Interacting proteins for ABCB4 (ENSP00000265723³) via UniProtKB, MINT, and/or STRING (see all 13 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
NR1H4	ENSP00000188403³	STRING (score=.961)
ATP8B1	ENSP00000283684³	STRING (score=.956)
HAX1	ENSP00000329002³	STRING (score=.951)
ABCG2	ENSP00000237612³	STRING (score=.85)
GGT4P	ENSP00000248923³	STRING (score=.839)

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4 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006629	lipid metabolic process	TAS	7912658
GO:0006810	transport	TAS	8106172
GO:0042493	response to drug	TAS	7912658
GO:0051384	response to glucocorticoid stimulus	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for ABCB4
7 Novoseek chemical compound relationships for ABCB4 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
phospholipid	67.45	28	9696021 (2), 14708891 (1), 9802889 (1), 17539998 (1) (see all 22)
estradiol-17beta-glucuronide	63.62	1	12388190 (1)
rhodamine 123	55.21	1	8105101 (1)
cholesterol	41.74	29	11313316 (4), 16698593 (4), 17786139 (3), 11745043 (2) (see all 8)
atp	19.76	11	19185004 (2), 15258199 (1), 19018976 (1), 17214987 (1) (see all 5)
lipid	13.22	4	17523162 (1), 19133130 (1), 9201967 (1)
oligonucleotide	0.00	1	15258199 (1)

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2 PharmGKB drug compound relationships for ABCB4 gene

Drug compound	PharmGKB Relations	PubMed IDs for articles supporting these relationships
azidothymidine	PD GN	20404014
doxorubicin	FA	11313874

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ABCB4)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ABCB4)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_000443

Sigma-Aldrich siRNA and siRNA Panels for ABCB4

Sigma-Aldrich shRNA for ABCB4

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000443 NM_018849 NM_018850

REFSEQ mRNAs for ABCB4 gene (3 alternative transcripts):

NM_000443.3 NM_018849.2 NM_018850.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000443 NM_018849 NM_018850

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_000443
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_000443
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_000443

Additional cDNA sequence:

BC020618.2 BC042531.1 M23234.1 X06181.1 Z35284.1

8 DOTS entries:

DT.91720305 DT.455047 DT.312416 DT.92417014 DT.95203605 DT.97777494 DT.99972053 DT.99987513

24 AceView cDNA sequences:

M23234 X06181 BC042531 BC020618 BX282642 AI708606 AA677416 BX325245

BF796582 NM_000443 CD245608 NM_018850 BX392299 BX325244 BG618391 BV167064

NM_018849 BQ324988 Z35284 BG772586 BM918731 BF671299 AI922477 BF885506

highest scoring ESTs for ABCB4:

M23234 BC042531 BG772586 Z35284 BC020618 BE090140 BF796582 BF885506 BG618391 BQ324988

Unigene Cluster for ABCB4:

ATP-binding cassette, sub-family B (MDR/TAP), member 4

Hs.654403 [show with all ESTs]

Unigene Representative Sequence: BC042531

GeneLoc Exon Structure

3 Ensembl transcripts including schematic representations:

ENST00000358400 ENST00000359206 ENST00000265723

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

ABCB4 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ABCB4

¹ / ² / ³

7 probe-sets matching ABCB4 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
33978_at²^{, 3}	U95-A	2	1.00	0.94	0.93	0.93	M23234	1.00	1.00	1.00	1
1576_g_at²^{, 3}	U95-A	2	1.00	0.50	0.93	1.10	M14758	0.20	0.10	0.16	2
207819_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_000443	0.60	1.00	0.82	1
209994_s_at²	U133-A	2	1.00	0.50	--	--	--	--	--	--	--
207819_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1570505_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
209994_s_at²	U133Plus2	2	1.00	0.50	--	--	--	--	--	--	--

GeneDecks ABCB4 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GCACGCATCA

SOURCE GeneReport for Unigene cluster: Hs.654403
Expression variation in blood from EXPOLDB for ABCB4

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ABCB4 gene from 5/11 species (see all 11 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
chimpanzee (Pan troglodytes)	ABCB4¹	--	ATP-binding cassette, sub-family B (MDR/TAP), member more	99.45(n) 99.21(a)	748364 XM_001160982.1 XP_001160982.1
rat (Rattus norvegicus)	Abcb4¹	--	ATP-binding cassette, sub-family B (MDR/TAP), member more	86.73(n) 91.38(a)	24891 NM_012690.1 NP_036822.1
mouse (Mus musculus)	Abcb4^{1, 5}	5 (1.00 cM)⁵	ATP-binding cassette, sub-family B (MDR/TAP), member more^{1, 5}	87.21(n)¹ 91.13(a)¹	18670¹ NM_008830.1¹ NP_032856.1¹ AA239419⁵ AK050345⁵ (see all 15)
fruit fly (Drosophila melanogaster)	CG10226³ Mdr49¹	65A10³	multidrug transporter³ Multi drug resistance 49¹	64(a) (best of 4)³ 50.79(n)¹ 44.64(a)¹	36428¹ NM_079000.2¹ NP_523724.2¹
worm (Caenorhabditis elegans)	pgp-2³	I(5897001-5903773)	abc transporter	46(a) (best of 10)	--

About this table Species with no ortholog for ABCB4

ENSEMBL Gene Tree for ABCB4

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for ABCB4 gene

ABCB1² SNRNP35² ABCB11²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/631 NCBI SNPs in ABCB4 are shown (see all 631 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 161)

AB	SNP ID	Valid	Chr 7 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs2097937^1,2	A,C,F,H,O	86868839(+)	`AGCTCA/GGTAGG`	3	--	ng5¹		20	EU EA WA NA NS	1524
	rs3747806^1,2	C,F,H	86944638(-)	`GAATTT/CGGGTT`	3	--	ng3¹		12	EA EU WA NA NS	2260
--	rs2071646^1,2	A,C,H	86943095(-)	`GCGCCC/TAGCCT`	3	--	ng3¹		4	EU EA WA	412
	rs11979496^1,2	C,F	86944616(+)	`ATGAGG/TATTCT`	3	--	ng3¹		6	NA NS	278
	rs2071645^1,2	F,H	86943212(-)	`TCCAGC/GCTGAT`	3	--	ng3¹		4	EU EA WA	418
	rs4148805^1,2	C,F	86944301(-)	`TAGATC/TCAATG`	3	--	ng3¹		5	NS	190
	rs4148807^1,2	C,F	86943748(-)	`AGGAGC/TAGAGA`	3	--	ng3¹		5	NS	186
--	rs2230028^1,2	F,O	86894112(-)	`CCACTA/GGAATG`	3	R/G	mis¹		22	MN NA EU EA WA NS	2056
	rs31655^1,2	C,H	86873728(+)	`CTTTGC/TTTCTT`	3	A/T	mis¹		8	EA NA MN EU WA	666
	rs1526089^1,2	C,F	86868967(+)	`AATTTA/GTTTTT`	3	--	ng5¹		7	EA NA NS	212

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HapMap Linkage Disequilibrium images for ABCB4 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 171060 disorders: 602347 147480 600803

UniProtKB/Swiss-Prot: MDR3_HUMAN, P21439

Defects in ABCB4 are the cause of progressive familial intrahepatic cholestasis type 3

(PFIC3) [MIM:602347]. PFIC3 is an autosomal recessive liver disorder presenting with early onset

cholestasis that progresses to cirrhosis and liver failure before adulthood. It is characterized

by elevated serum gamma-glutamyltransferase levels

Defects in ABCB4 are a cause of intrahepatic cholestasis of pregnancy (ICP) [MIM:147480];

also known as obstetric cholestasis. ICP is a multifactorial liver disorder of pregnancy. It

presents during the second or, more commonly, the third trimestre of pregnancy with intense

pruritus which becomes more severe with advancing gestation and cholestasis. Cholestasis results

from abnormal biliary transport from the liver into the small intestine. ICP causes fetal

distress, spontaneous premature delivery and intrauterine death. ICP patients have spontaneous and

progressive disappearance of cholestasis after delivery

Genetic variations in ABCB4 may play a role in drug-induced cholestasis causing liver

damage

Defects in ABCB4 are a cause of cholelithiasis [MIM:600803]; also known as gallstones

10/32 Novoseek disease relationships for ABCB4 gene (see all 32 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
pfic3	96.85	24	11745043 (4), 17726488 (4), 12671900 (2), 12967592 (1) (see all 9)
cholestasis intrahepatic	92.62	47	18083082 (4), 11420418 (3), 16696816 (3), 9419367 (2) (see all 26)
pfic2	90.41	6	16763017 (1), 17241866 (1)
byler disease	84.37	2	17241866 (1)
cholestasis	84.01	38	17264802 (3), 12381474 (3), 12206920 (3), 11420418 (2) (see all 18)
biliary cirrhosis	71.08	5	11420418 (1), 12671900 (1), 17295178 (1), 17273143 (1)
liver diseases	64.47	3	11745043 (1), 17295178 (1), 18781607 (1)
biliary cirrhosis primary	56.68	6	14999697 (2), 9126799 (1), 17295178 (1)
cholelithiasis	49.32	10	17786139 (2), 17273143 (2), 11313316 (1), 12671900 (1) (see all 6)
leukemia prolymphocytic	49.06	2	2323839 (2)

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Human Gene Mutation Database: ABCB4
Genetic Association Database: ABCB4
Human Genome Epidemiology Navigator: ABCB4 (19 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/166 PubMed articles for ABCB4 gene (see all 166 ):

Sequence analysis of bile salt export pump (ABCB11) and multidrug resistance p-glycoprotein 3 (ABCB4, MDR3) in patients with intrahepatic cholestasis of pregnancy. (PubMed id 15077010)^{1, 3, 4, 6} Pauli-Magnus C.... Kullak-Ublick G.A. (2004)
MDR3 gene defect in adults with symptomatic intrahepatic and gallbladder cholesterol cholelithiasis. (PubMed id 11313316)^{1, 2, 3, 4} Rosmorduc O....Poupon R. (2001)
ABCB4 gene mutation-associated cholelithiasis in adults. (PubMed id 12891548)^{3, 4, 6} Rosmorduc O....Poupon R. (2003)
The human mdr3 gene encodes a novel P-glycoprotein homologue and gives rise to alternatively spliced mRNAs in liver. (PubMed id 2892668)^{2, 3, 4} van der Bliek A.M.... Borst P. (1987)
BSEP and MDR3 haplotype structure in healthy Caucasians, primary biliary cirrhosis and primary sclerosing cholangitis. (PubMed id 14999697)^{1, 3, 6} Pauli-Magnus C....Meier P.J. (2004)
Mutations and polymorphisms in the bile salt export pump and the multidrug resistance protein 3 associated with drug-induced liver injury. (PubMed id 17264802)^{1, 3, 4} Lang C.... Pauli-Magnus C. (2007)
Genetic variability, haplotype structures, and ethnic diversity of hepatic transporters MDR3 (ABCB4) and bile salt export pump (ABCB11). (PubMed id 16763017)^{1, 3, 4} Lang T.... Kerb R. (2006)
Heterozygous MDR3 missense mutation associated with intrahepatic cholestasis of pregnancy: evidence for a defect in protein trafficking. (PubMed id 10767346)^{1, 3, 4} Dixon P.H.... Williamson C. (2000)
Characterization of the promoter region of the human MDR3 P- glycoprotein gene. (PubMed id 7893760)^{1, 3, 4} Smit J.J....Borst P. (1995)
Structure of the human MDR3 gene and physical mapping of the human MDR locus. (PubMed id 2002063)^{1, 3, 4} Lincke C.R.... Borst P. (1991)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 5244	HGNC: 45	AceView: ABCB4	Ensembl:ENSG00000005471	euGenes: HUgn5244
ECgene: ABCB4	H-InvDB: ABCB4

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
GeneReviews	http://www.genetests.org/query?gene=ABCB4
NIEHS-SNPs	http://egp.gs.washington.edu/data/abcb4/

Licensable Technologies for ABCB4
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for ABCB4:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ABCB4-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ABCB4		Antibodies for ABCB4
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for ABCB4		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Search for Recombinant Proteins
	Antibodies (ABCB4)
	Chimera RNAi (ABCB4)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (ABCB4)
	Antibodies (ABCB4)

Search OriGene for ABCB4

Search Tocris compounds for ABCB4

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Search Novus for antibodies for ABCB4

GeneCards Homepage - Last full update: 1 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
ABCB4 Gene at Home site.
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ABCB4 Gene

protein-coding GIFtS: 62

Aliases &
Descriptions
for ABCB4

Summaries
for ABCB4

Genomic Location
for ABCB4

Proteins
for ABCB4

Protein Domains/
Families
for ABCB4

Gene Function
for ABCB4

Pathways & Interactions
for ABCB4

Drugs & Compounds
for ABCB4

Transcripts
for ABCB4

Expression
for ABCB4

Orthologs
for ABCB4

Paralogs
for ABCB4

SNPs/Variants
for ABCB4

Disorders & Mutations
for ABCB4

Medical News
for ABCB4

Publications
for ABCB4

Search for ABCB4

Genome Databases showing ABCB4

Other Databases showing ABCB4

Specialized Databases showing ABCB4

Licensable Technologies
for ABCB4

Services
for ABCB4

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ABCB4 Gene

protein-coding GIFtS: 62

Aliases & Descriptionsfor ABCB4

Summariesfor ABCB4

Genomic Locationfor ABCB4

Proteinsfor ABCB4

Protein Domains/Familiesfor ABCB4

Gene Functionfor ABCB4

Pathways & Interactionsfor ABCB4

Drugs & Compoundsfor ABCB4

Transcriptsfor ABCB4

Expression for ABCB4

Orthologsfor ABCB4

Paralogsfor ABCB4

SNPs/Variantsfor ABCB4

Disorders & Mutationsfor ABCB4

Medical Newsfor ABCB4

Publicationsfor ABCB4

Search for ABCB4

Genome Databases showing ABCB4

Other Databases showing ABCB4

Specialized Databases showing ABCB4

Licensable Technologiesfor ABCB4

Servicesfor ABCB4

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ABCB4

Summaries
for ABCB4

Genomic Location
for ABCB4

Proteins
for ABCB4

Protein Domains/
Families
for ABCB4

Gene Function
for ABCB4

Pathways & Interactions
for ABCB4

Drugs & Compounds
for ABCB4

Transcripts
for ABCB4

Expression
for ABCB4

Orthologs
for ABCB4

Paralogs
for ABCB4

SNPs/Variants
for ABCB4

Disorders & Mutations
for ABCB4

Medical News
for ABCB4

Publications
for ABCB4

Licensable Technologies
for ABCB4

Services
for ABCB4