Aliases for ABCB11 Gene
External Ids for ABCB11 Gene
Previous Symbols for ABCB11 Gene
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is the major canalicular bile salt export pump in man. Mutations in this gene cause a form of progressive familial intrahepatic cholestases which are a group of inherited disorders with severe cholestatic liver disease from early infancy. [provided by RefSeq, Jul 2008]
GeneCards Summary for ABCB11 Gene
ABCB11 (ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 11) is a Protein Coding gene. Diseases associated with ABCB11 include cholestasis, benign recurrent intrahepatic, 2 and cholestasis, progressive familial intrahepatic 2. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include transporter activity and sodium-exporting ATPase activity, phosphorylative mechanism. An important paralog of this gene is ABCB1.
UniProtKB/Swiss-Prot for ABCB11 Gene
Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes