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ABCB11 Gene

protein-coding   GIFtS: 60

GC02M169487
ATP-binding cassette, sub-family B (MDR/TAP), member 11
(Previous name: progressive familial intrahepatic cholestasis 2 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: BSEP, PFIC2)
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases
ABC16 1, 2
BRIC2 2, 5
BSEP 2, 3, 5
PFIC-2 1, 2
PFIC2 2, 5
PGY4 1, 2
SPGP 1, 2, 5
Descriptions
ABC member 16, MDR/TAP subfamily 2
ATP-binding cassette sub-family B member 11 3
ATP-binding cassette, sub-family B (MDR/TAP), member 11 2
bile salt export pump 2
progressive familial intrahepatic cholestasis 2 1, 2
sister p-glycoprotein 2
External Ids
HGNC: 421
Entrez Gene: 86472
UniProtKB: O953423
Ensembl: ENSG000000737347
Search outside databases for aliases for ABCB11 gene

Previous GC identifers: GC02M167831 GC02M168321 GC02M169743 GC02M169981 GC02M169604

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for ABCB11:
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding
cassette (ABC) transporters. ABC proteins transport various molecules across extra- and
intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP,
MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the
MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is the
major canalicular bile salt export pump in man. Mutations in this gene cause a form of progressive
familial intrahepatic cholestases which are a group of inherited disorders with severe cholestatic
liver disease from early infancy. [provided by RefSeq]

UniProtKB/Swiss-Prot: ABCBB_HUMAN, O95342
Function: Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the ABCB11 gene  

Entrez Gene cytogenetic band: 2q24   Ensembl cytogenetic band:  2q31.1   HGNC cytogenetic band: 2q24

ABCB11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M169487:     (about GC identifiers)

Start:
169,487,694 bp from pter
End:
169,596,079 bp from pter
Size:
108,386 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000002.10  NT_005403.16  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: ABCBB_HUMAN, O95342 (See protein sequence)
Recommended Name: Bile salt export pump  
Size: 1321 amino acids; 146393 Da
Subcellular location: Membrane; Multi-pass membrane protein
Secondary accessions: Q9UNB2

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_003733.2  

    ENSEMBL proteins: 
    ENSP00000263817 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Sigma-Aldrich Proteins for ABCB11  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (ABCB11)
    Browse Abnova for Human Recombinant Proteins
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    5 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005624 membrane fraction TAS9806540
    GO:0005887 integral to plasma membrane TAS9806540
    GO:0016020 membrane IEA--
    GO:0045177 apical part of cell IEA--
    GO:0046581 intercellular canaliculus IEA--
    About this table

    Antibodies for ABCB11: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for ABCB11
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (ABCB11), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (ABCB11)
    Search Novus for antibodies for ABCB11

    Assays for ABCB11: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    5 InterPro domains/families:
     IPR003593 ATPase_AAA+_core
     IPR003439 ABC_transporter-like
     IPR017940 ABC_transporter_type1
     IPR001140 ABC_TM_transpt
     IPR017871 ABC_transporter_CS


       GeneDecks  ABCB11 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry O95342

    ProtoNet protein and cluster: O95342

    UniProtKB/Swiss-Prot: ABCBB_HUMAN, O95342
    Domain: Multifunctional polypeptide with two homologous halves, each containing an hydrophobic
    membrane-anchoring domain and an ATP binding cassette (ABC) domain
    Similarity: Belongs to the ABC transporter family. Multidrug resistance exporter (TC 3.A.1.201)
    subfamily
    Similarity: Contains 2 ABC transmembrane type-1 domains
    Similarity: Contains 2 ABC transporter domains

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (ABCB11)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (ABCB11)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003742

                  Applied Biosystems Silencer® siRNAs for ABCB11

                  Sigma-Aldrich siRNA and siRNA Panels for ABCB11  
                         Sigma-Aldrich shRNA for ABCB11  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Browse Clone Ranger at Invitrogen for clones
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_003742
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_003742
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_003742 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_003742

    UniProtKB/Swiss-Prot: ABCBB_HUMAN, O95342
    Function: Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes
    Biophysicochemical properties: Kinetic parameters: KM=30.4 uM for taurocholate; Vmax=232
    pmol/min/mg enzyme for taurocholate transport;

    Genatlas biochemistry entry for ABCB11:
    ATP binding cassette superfamily,subfamily B (MDR/TAP) member 11,expressed in the canalicular
    microvilli and subcanicular vesicles of the hepatocytes

    3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Abcb11):

    growth/sizehomeostasis/metabolismliver/biliary system

    5/6 Gene Ontology (GO) molecular function terms (links to tree view) (see all 6 ):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166 nucleotide binding IEA--
    GO:0005215 transporter activity TAS9806540
    GO:0005524 ATP binding TAS9806540
    GO:0008554 sodium-exporting ATPase activity, phosphorylative mechanism TAS9806540
    GO:0015432 bile acid-exporting ATPase activity TAS9806540
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


    4 Sigma-Aldrich "Your Favorite Gene" Pathways for  ABCB11  (Your Favorite Gene powered by Ingenuity) 
     FXR/RXR Activation
     Hepatic Cholestasis
     PXR/RXR Activation
     LPS/IL-1 Mediated Inhibition of RXR Function

       GeneDecks  ABCB11 for the pathways selected above  
    About GeneDecksing

    1 Kegg Pathway  (Kegg details for ABCB11):
     hsa02010 ABC transporters

       GeneDecks  ABCB11 for the pathways selected above  
    About GeneDecksing
     Gene Network CentralTM Interacting Genes and Proteins Network for  ABCB11 


    5/24 Interacting proteins for ABCB11 (ENSP000002638173) via UniProtKB, MINT, and/or STRING (see all 24 )
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NR1H4ENSP000001884033STRING (score=.977)
    SLC10A1ENSP000002165403STRING (score=.973)
    SLCO1B1ENSP000002569583STRING (score=.973)
    SLCO1B3ENSP000003709563STRING (score=.972)
    ATP8B1ENSP000002836843STRING (score=.968)
    About this table

    1 Gene Ontology (GO) biological process term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810 transport TAS9806540
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for ABCB11
    10/30 Novoseek chemical compound relationships for ABCB11 gene (see all 30 )
    Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    bodipy-verapamil 84.25 2 1681415 (1), 15308763 (1)
    azidopine 74.37 1 1360010 (1)
    gf 120918 72.18 3 16940108 (1), 12384350 (1)
    tariquidar 71.80 6 19034106 (3), 15986399 (2)
    rhodamine 123 71.72 5 7646552 (1), 7504150 (1), 10617675 (1), 7929531 (1) (see all 5)
    colchicine 68.78 4 9220975 (1), 15049699 (1), 7909160 (1), 9551613 (1)
    vanadate 63.81 1 9482283 (1)
    ly335979 62.16 1 16940108 (1)
    atp 57.73 34 16505485 (2), 8093688 (2), 12404240 (2), 16489767 (2) (see all 25)
    cholic acid 46.68 3 14684751 (3)
    About this table


    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (ABCB11)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (ABCB11)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003742

                  Sigma-Aldrich siRNA and siRNA Panels for ABCB11  
                         Sigma-Aldrich shRNA for ABCB11  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_003742  

    REFSEQ mRNAs for ABCB11 gene: 

    NM_003742.2   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_003742  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_003742
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_003742
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_003742 

    Additional cDNA sequence: 

    AB012959.1 AF091582.1 AF136523.1 AK302540.1 AK303050.1 

    4 DOTS entries:

    DT.92072028  DT.91751051  DT.97804514  DT.401532 

    21 AceView cDNA sequences:

    AA718934 AI247467 NM_003742 AB012959 BV198883 CB161905 AF091582 BX110920 
    AA682405 BV198828 CD617437 BM312770 CD617439 BM312461 BX494965 BX494964 
    AA345915 AF136523 AI052627 CB161524 R91010 

    highest scoring ESTs for ABCB11:

    AF091582 AF136523 CD617436 CD617437 CD617438 CD617439 NM_003742 AB012959 AV688259 BF876579 

    Unigene Cluster for ABCB11:

    ATP-binding cassette, sub-family B (MDR/TAP), member 11
    Hs.658439  [show with all ESTs]
    Unigene Representative Sequence: AF091582


    GeneLoc Exon Structure

    1 Ensembl transcript including schematic representation:
    ENST00000263817  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    ABCB11 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for ABCB11

    1 / 2 / 3

    5 probe-sets matching ABCB11 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    31398_at2, 3 U95-A 1 1.00 1.00 1.00 1.00 AF091582 1.00 1.00 1.00 1

    208288_at2, 3 U133-A 1 1.00 1.00 -- -- NM_003742 0.60 1.00 0.82 1

    211224_s_at2, 3 U133-A 1 1.00 1.00 -- -- AF136523 0.80 1.00 0.91 1

    208288_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    211224_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    About this table
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: AGCTTTCCAG

    SOURCE GeneReport for Unigene cluster: Hs.658439

    Expression variation in blood from EXPOLDB for ABCB11

    UniProtKB/Swiss-Prot: ABCBB_HUMAN, O95342
    Tissue specificity: Expressed predominantly, if not exclusively in the liver, where it was further
    localized to the canalicular microvilli and to subcanalicular vesicles of the hepatocytes by in
    situ (By similarity)

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for ABCB11 gene from 5/9 species (see all 9 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    ABCB111   -- ATP-binding cassette, sub-family B (MDR/TAP), member more 89.07(n)
    89.7(a)
    488390  XM_545512.2  XP_545512.2 
    chimpanzee
    (Pan troglodytes)
    ABCB111   -- ATP-binding cassette, sub-family B (MDR/TAP), member more 99.22(n)
    99.32(a)
    470717  XM_526100.2  XP_526100.2 
    cow
    (Bos taurus)
    ABCB111   -- ATP-binding cassette, sub-family B (MDR/TAP), member more 88.87(n)
    88.27(a)
    531150  XM_609636.3  XP_609636.3 
    mouse
    (Mus musculus)
    Abcb111, 5 2 (38.40 cM)5
    ATP-binding cassette, sub-family B (MDR/TAP), member more1, 5 83.14(n)1
    82.03(a)1
    274131  NM_021022.31  NP_066302.21 
     AA0663415  AF1339035  (see all 15)
    zebrafish
    (Danio rerio)
    Dr.287002   -- Transcribed sequence with weak similarity to protein more 76.33(n)  57049999 
    About this table        Species with no ortholog for ABCB11

    ENSEMBL Gene Tree for ABCB11
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for ABCB11 gene
    ABCB12  SNRNP352  ABCB42  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/835 NCBI SNPs in ABCB11 are shown (see all 835 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 328)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 2 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs22165041,2
    A,C,F,H,O169597354(-) TTTGCG/ATCAAC 1 -- ng318Minor allele frequency- A:0.08EU EA WA NA 1678
    rs4783331,2
    A,C,F,H,O169487402(-) GATGCT/CACCTG 1 -- ng5111Minor allele frequency- C:0.45EA MN EU WA 1202
    rs4733511,2
    A,C,F,H169488142(-) TCCATA/C/G/
            
    TGAGG
    1 -- ut31 ese312EU EA WA NA 2358
    rs22876221,2
    A,C,F,H169538574(-) CATGGA/C/G/
            
    CATTA
    3 V/D V/A V/G mis1 ese320EA EU WA NA MN CSAM 3628
    rs38298881,2
    A,C,F,H169597088(-) ATTTCT/CGCAAA 1 -- ng31 tfbs34Minor allele frequency- C:0.08EU EA WA 410
    rs4965501,2
    A,C,F,H169487958(-) GGTCTG/ATAACA 1 -- ut31 ese319Minor allele frequency- A:0.47NA EA MN EU WA CSAM 3014
    rs115683611,2
    C,F,H169578250(-) TTCATC/TAACTG 1 S/L mis1 ese36Minor allele frequency- T:0.01EU EA WA NA 648
    --
    rs4957141,2
    A,C,F169488010(-) CAAGGG/ACAGAG 1 -- ut315Minor allele frequency- A:0.46MN CSAM EA 396
    rs22413381,2
    C,F,H169596214(-) CACACT/CCTGTG 1 -- ng314Minor allele frequency- C:0.07EU EA WA 370
    rs41487651,2
    C,F,H169597825(-) AGCACG/AATCAA 1 -- ng3115Minor allele frequency- A:0.09NA EU EA WA 1394
    About this table

    HapMap Linkage Disequilibrium images for ABCB11 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 603201   disorders: 601847  605479  

    UniProtKB/Swiss-Prot: ABCBB_HUMAN, O95342

  • Defects in ABCB11 are the cause of progressive familial intrahepatic cholestasis type 2
    (PFIC2) [MIM:601847]. PFIC2 is an inherited liver disease of childhood which is characterized by
    cholestasis and normal serum gamma-glutamyltransferase activity. Defects in ABCB11 are also found
    in cases of chronic intrahepatic cholestasis without obvious familial history of chronic liver
    disease
  • Defects in ABCB11 are the cause of benign recurrent intrahepatic cholestasis type 2
    (BRIC2) [MIM:605479]. BRIC is characterized by intermittent episodes of cholestasis without
    progression to liver failure. There is initial elevation of serum bile acids, followed by
    cholestatic jaundice which generally spontaneously resolves after periods of weeks to months. The
    cholestatic attacks vary in severity and duration and patients are asymptomatic between episodes,
    both clinically and biochemically
  • Genetic variations in ABCB11 may play a role in drug-induced cholestasis causing liver
    damage
  • 10/30 Novoseek disease relationships for ABCB11 gene (see all 30 )

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    pfic2 91.74 20 16039748 (4), 11172067 (3), 9806540 (2), 18487280 (1) (see all 8)
    pfic3 85.52 2 17241866 (1)
    cholestasis intrahepatic 83.57 33 16039748 (3), 11172067 (3), 11815775 (2), 11870371 (1) (see all 16)
    byler disease 80.71 8 16819395 (1), 19133130 (1), 17241866 (1)
    colchicine resistance 73.97 2 15049699 (1), 7909160 (1)
    cholestasis 67.44 25 17264802 (4), 17108234 (1), 12739759 (1), 11230744 (1) (see all 11)
    cancer 33.69 18 17640301 (2), 16875827 (1), 12678765 (1), 1681415 (1) (see all 16)
    liver diseases 30.92 3 12536246 (1), 14699511 (1), 18509747 (1)
    biliary cirrhosis primary 24.99 3 14999697 (2)
    leukemia 23.66 2 10456672 (1), 7907642 (1)
    About this table

    GeneTests: ABCB11
    Low Gamma-GT Familial Intrahepatic Cholestasis

    Human Gene Mutation Database: ABCB11
    Genetic Association Database: ABCB11
    Human Genome Epidemiology Navigator: ABCB11 (15 documents)

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/319 PubMed articles for ABCB11 gene (see all 319 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 8647 HGNC: 42 AceView: ABCB11 Ensembl:ENSG00000073734 euGenes: HUgn8647
    ECgene: ABCB11 H-InvDB: ABCB11
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

    NameDescription
    GeneReviewshttp://www.genetests.org/query?gene=ABCB11
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for ABCB11:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
      Invitrogen Clones  Invitrogen Q-PCR Products
      Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for ABCB11-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for ABCB11 Antibodies for ABCB11
     Explore super-pooled esiRNAs Proteins for ABCB11
     Lentivirus-delivered shRNAs for ABCB11 Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
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     Recombinant & Natural Proteins  

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