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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ABCB10 Gene

protein-coding   GIFtS: 62
GCID: GC01M229652

ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 10

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 101 2     ATP-Binding Cassette Sub-Family B Member 101
ABC Transporter 10 Protein1 2 3     mitochondrial1
ATP-Binding Cassette Transporter 101 2 3     EST202372
Mitochondrial ATP-Binding Cassette 21 2 3     ATP-Binding Cassette Sub-Family B Member 10, Mitochondrial2
M-ABC22 3     EC 3.6.38
MTABC22 5     EC 3.6.3.448

External Ids:    HGNC: 411   Entrez Gene: 234562   Ensembl: ENSG000001357767   OMIM: 6054545   UniProtKB: Q9NRK63   

Export aliases for ABCB10 gene to outside databases

Previous GC identifers: GC01M228099 GC01M225346 GC01M226051 GC01M226613 GC01M225959 GC01M227718 GC01M200142


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ABCB10 Gene:
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC)
transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are
divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member
of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The function of
this mitochondrial protein is unknown. (provided by RefSeq, Jul 2008)

GeneCards Summary for ABCB10 Gene: 
ABCB10 (ATP-binding cassette, sub-family B (MDR/TAP), member 10) is a protein-coding gene. Diseases associated with ABCB10 include bare lymphocyte syndrome, and acute myeloid leukemia, and among its related super-pathways are ABC-family proteins mediated transport and SLC-mediated transmembrane transport. GO annotations related to this gene include protein homodimerization activity and oligopeptide-transporting ATPase activity. An important paralog of this gene is TAP2.

UniProtKB/Swiss-Prot: ABCBA_HUMAN, Q9NRK6
Function: May mediate critical mitochondrial transport functions related to heme biosynthesis (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_167186.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ABCB10 gene promoter:
         TBP   Nkx3-1   Nkx3-1 v4   Pbx1a   AML1a   Nkx3-1 v1   YY1   Nkx3-1 v2   TFIID   Nkx3-1 v3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidABCB10 promoter sequence
   Search SABiosciences Chromatin IP Primers for ABCB10

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ABCB10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q42.13   Ensembl cytogenetic band:  1q42.13   HGNC cytogenetic band: 1q32

ABCB10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ABCB10 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M229652:  view genomic region     (about GC identifiers)

Start:
229,652,329 bp from pter      End:
229,694,442 bp from pter
Size:
42,114 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ABCBA_HUMAN, Q9NRK6 (See protein sequence)
Recommended Name: ATP-binding cassette sub-family B member 10, mitochondrial precursor  
Size: 738 amino acids; 79148 Da
Subunit: Homodimer or homooligomer
Subcellular location: Mitochondrion inner membrane; Multi-pass membrane protein
4 PDB 3D structures from and Proteopedia for ABCB10:
3ZDQ (3D)        4AYT (3D)        4AYW (3D)        4AYX (3D)    
Secondary accessions: Q13040 Q6P1Q8 Q9H3V0

Explore the universe of human proteins at neXtProt for ABCB10: NX_Q9NRK6

Explore proteomics data for ABCB10 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9NRK6

  • 4/5 DME Specific Peptides for ABCB10 (Q9NRK6) (see all 5)
     AHRLSTI  KILLLDE  QRIAIARA  VIAHRLST 

    ABCB10 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ABCB10 Protein Expression
    REFSEQ proteins: NP_036221.2  
    ENSEMBL proteins: 
     ENSP00000355637  
    Reactome Protein details: Q9NRK6
    Human Recombinant Protein Products for ABCB10: 
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    Novus Biologicals ABCB10 Protein
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ABCB10 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion ----
    GO:0005743mitochondrial inner membrane IBA--
    GO:0005886NOT plasma membrane IRD--
    GO:0016021integral to membrane ----
    GO:0032592integral to mitochondrial membrane IDA10922475

    ABCB10 for ontologies           About GeneDecksing



    ABCB10 Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ABCB: ATP binding cassette transporters / subfamily B

    IUPHAR Guide to PHARMACOLOGY protein family classification: ABCB10 
    ABCB subfamily

    5/7 InterPro protein domains (see all 7):
     IPR003439 ABC_transporter-like
     IPR027417 P-loop_NTPase
     IPR001140 ABC_transptr_TM_dom
     IPR003593 AAA+_ATPase
     IPR017940 ABC_transporter_type1

    Graphical View of Domain Structure for InterPro Entry Q9NRK6

    ProtoNet protein and cluster: Q9NRK6

    UniProtKB/Swiss-Prot: ABCBA_HUMAN, Q9NRK6
    Similarity: Belongs to the ABC transporter superfamily. ABCB family. Mitochondrial peptide exporter (TC 3.A.1.212)
    subfamily
    Similarity: Contains 1 ABC transmembrane type-1 domain
    Similarity: Contains 1 ABC transporter domain


    ABCB10 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ABCBA_HUMAN, Q9NRK6
    Function: May mediate critical mitochondrial transport functions related to heme biosynthesis (By similarity)

         Genatlas biochemistry entry for ABCB10:
    ATP-binding cassette superfamily,sufamily B (MDR/TAP),member 10

         Enzyme Numbers (IUBMB): EC 3.6.3.442 EC 3.6.32

         Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding ----
    GO:0005215transporter activity NAS10922475
    GO:0005524ATP binding IEA--
    GO:0015421oligopeptide-transporting ATPase activity IBA--
    GO:0016887ATPase activity ----
         
    ABCB10 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for ABCB10:
     Decreased influenza A/WSN/33 r  Increased cell death HMECs cel 

         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Abcb10):
     cardiovascular system  cellular  homeostasis/metabolism  mortality/aging 

    ABCB10 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ABCB10 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ABCB10

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ABCB10 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ABCB10 

    miRNA
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    8/21 QIAGEN miScript miRNA Assays for microRNAs that regulate ABCB10 (see all 21):
    hsa-miR-140-5p hsa-miR-579 hsa-miR-607 hsa-miR-128 hsa-miR-219-5p hsa-miR-1323 hsa-miR-3148 hsa-miR-3163
    SwitchGear 3'UTR luciferase reporter plasmidABCB10 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Gene Editing
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    Clone
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ABCB10


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ABCB10 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1ABC-family proteins mediated transport
    ABC-family proteins mediated transport0.70
    ABC transporters0.70
    2SLC-mediated transmembrane transport
    Transmembrane transport of small molecules0.50
    3Mitochondrial ABC transporters
    Mitochondrial ABC transporters

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3        Reactome Pathways for ABCB10
        ABC-family proteins mediated transport
    Transmembrane transport of small molecules
    Mitochondrial ABC transporters


    1         Kegg Pathway  (Kegg details for ABCB10):
        ABC transporters


    ABCB10 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ABCB10

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    5/26 Interacting proteins for ABCB10 (Q9NRK63 ENSP000003556374) via UniProtKB, MINT, STRING, and/or I2D (see all 26)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ABCB7O750273I2D: score=1 
    CNBPP626333I2D: score=1 
    CRLS1Q9UJA23I2D: score=1 
    FZR1Q9UM113I2D: score=1 
    HSPA9P386463I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport NAS10922475
    GO:0055085transmembrane transport IBA--

    ABCB10 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ABCB10 (ABCBA)

    1 HMDB Compound for ABCB10    About this table
    CompoundSynonyms CAS #PubMed Ids
    Heme(protoporphyrinato)iron (see all 19)14875-96-8--

    Search CenterWatch for drugs/clinical trials and news about ABCB10 / ABCBA

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ABCB10 gene: 
    NM_012089.2  

    Unigene Cluster for ABCB10:

    ATP-binding cassette, sub-family B (MDR/TAP), member 10
    Hs.17614  [show with all ESTs]
    Unigene Representative Sequence: AB013380
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000344517(uc001htp.4) ENST00000498158 ENST00000486755
    miRNA
    Products:
         
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    8/21 QIAGEN miScript miRNA Assays for microRNAs that regulate ABCB10 (see all 21):
    hsa-miR-140-5p hsa-miR-579 hsa-miR-607 hsa-miR-128 hsa-miR-219-5p hsa-miR-1323 hsa-miR-3148 hsa-miR-3163
    SwitchGear 3'UTR luciferase reporter plasmidABCB10 3' UTR sequence
    Inhib. RNA
    Products:
         
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    GenScript: all cDNA clones in your preferred vector: ABCB10 (NM_012089)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ABCB10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ABCB10
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ABCB10

    Additional mRNA sequence: 

    AB013380.1 AF216833.1 AF277184.1 AK172794.1 BC064930.1 DQ786241.1 U18237.1 

    8 DOTS entries:

    DT.99978524  DT.413314  DT.100727801  DT.100782903  DT.100830974  DT.40106166  DT.40235154  DT.95254945 

    24/122 AceView cDNA sequences (see all 122):

    AA045640 BQ575633 BX403383 BQ022623 BC064930 BM718393 AI338028 AU124835 
    BQ023945 CK906289 BM126834 CA433072 BX281688 BQ229972 BM683451 BX106160 
    AA434506 AI472910 BX494345 AW264099 BM982301 BM769842 BX507406 H28322 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ABCB10 expression in normal human tissues (normalized intensities)      ABCB10 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGTTCAATT
    ABCB10 Expression
    About this image


    ABCB10 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 3 entries
             Myoblasts Mandibular Arch Muscles
             gastrocnemius muscle   
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Proerythroblasts Hematopoietic Bone Marrow
             bone marrow   
     
     Heart (Cardiovascular System)
             Cardiac Crescent Cells Cardiac Crescent
     
     Bone (Muscoskeletal System)
             bone marrow   
     
     Liver (Hepatobiliary System)

    See ABCB10 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ABCB10

    SOURCE GeneReport for Unigene cluster: Hs.17614

    UniProtKB/Swiss-Prot: ABCBA_HUMAN, Q9NRK6
    Tissue specificity: Ubiquitous. Highly expressed in bone marrow, expressed at intermediate to high levels in
    skeletal muscle, small intestine, thyroid, heart, brain, placenta, liver, pancreas, prostate, testis, ovary,
    leukocyte, stomach, spinal cord, lymph node, trachea and adrenal gland, and low levels are found in lung, kidney,
    spleen, thymus and colon

        SABiosciences Custom PCR Arrays for ABCB10
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ABCB10

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ABCB10 gene from 10/27 species (see all 27)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Abcb101 , 5 ATP-binding cassette, sub-family B (MDR/TAP), member more1, 5 78.84(n)1
    80.3(a)1
      8 (72.31 cM)5
    561991  NM_019552.21  NP_062425.11 
     1239524595 
    chicken
    (Gallus gallus)
    Aves ABCB101 ATP-binding cassette, sub-family B (MDR/TAP), member more 75.85(n)
    82.16(a)
      421537  XM_419578.2  XP_419578.2 
    lizard
    (Anolis carolinensis)
    Reptilia ABCB106
    Uncharacterized protein
    78(a)
    1 ↔ 1
    1(222273426-222303069)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.153412 Xenopus laevis transcribed sequence with moderate similarity more 77.01(n)    BJ045453.1 
    zebrafish
    (Danio rerio)
    Actinopterygii abcb101 ATP-binding cassette, sub-family B (MDR/TAP), member more 66.38(n)
    71.01(a)
      100003744  XM_001343182.4  XP_001343218.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG102263
    CG31561
    multidrug transporter3
    CG31561
    58(a)
    (best of 2)3
    53.98(n)1
    50.51(a)1
      65A103
    309941  NM_130488.21  NP_569844.21 
    worm
    (Caenorhabditis elegans)
    Secernentea haf-31 Protein HAF-3 50.46(n)
    45.52(a)
      180056  NM_074526.5  NP_506927.2 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MDL1(YLR188W)4
    MDL11
    Mitochondrial inner membrane half-type ATP-binding more4
    Mdl1p1
    48.07(n)1
    44.21(a)1
      12(528300-530387)4
    8508851, 4  NP_013289.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons TAP21 ABC transporter B family member 27 49.77(n)
    44.73(a)
      833896  NM_123266.7  NP_198720.2 
    rice
    (Oryza sativa)
    Liliopsida Os.92202 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 74.55(n)    AK069342.1 


    ENSEMBL Gene Tree for ABCB10 (if available)
    TreeFam Gene Tree for ABCB10 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ABCB10 gene
    TAP22  ENSG000002502642  ABCB82  ABCB92  TAP12  
    8 SIMAP similar genes for ABCB10 using alignment to 1 protein entry:     ABCBA_HUMAN:
    ABCB4    ABCB8    ABCB11    ABCB9    ABCB1    ABCB5
    TAP2    TAP1

    ABCB10 for paralogs           About GeneDecksing


    5 Pseudogenes.org Pseudogenes for ABCB10
    PGOHUM00000246654 PGOHUM00000246689 PGOHUM00000247024 PGOHUM00000260648 PGOHUM00000260659


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1016 SNPs in ABCB10 are shown (see all 1016)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0357354
    A breast cancer sample4--see VAR_0357352 R T mis40--------
    rs1143220891,2
    F--229651829(+) TAAATT/CACAGG 1 -- ds50011Minor allele frequency- C:0.01WA 118
    rs1835349901,2
    --229651868(+) AACACG/TCTGGA 1 -- ds50010--------
    rs1391061071,2
    --229652040(+) AGTTCA/CTTGTC 1 -- ds50010--------
    rs1885343841,2
    --229652041(+) GTTCCC/TTGTCC 1 -- ds50010--------
    rs1927767901,2
    --229652071(+) CTTATG/TTACTG 1 -- ds50010--------
    rs1848093341,2
    --229652089(+) ACAATG/TAAACA 1 -- ds50010--------
    rs561446961,2
    C--229652389(+) TGAACA/GTCATG 1 -- ut310--------
    rs1430919331,2
    --229652450(+) TGGCAC/TAAGGA 1 -- ut310--------
    rs1869750101,2
    --229652475(+) TTCAAC/TCTTGT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for ABCB10 (229652329 - 229694442 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for ABCB10:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv28834CNV Loss19812545
    nsv827130CNV Gain20364138

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605454    OMIM disorders: --

    7 diseases for ABCB10:    About MalaCards
    bare lymphocyte syndrome    acute myeloid leukemia    myeloid leukemia    tuberculosis
    thyroiditis    leukemia    prostatitis


    ABCB10 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ABCB10
    Human Genome Epidemiology (HuGE) Navigator: ABCB10 (2 documents)

    Export disorders for ABCB10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ABCB10 gene, integrated from 9 sources (see all 24):
    (articles sorted by number of sources associating them with ABCB10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization and mapping of three new mammalian ATP-binding transporter genes from an EST database. (PubMed id 7766993)1, 2, 3 Allikmets R.... Dean M. (1995)
    2. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (2010)
    3. Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects. (PubMed id 19343046)1, 4 Saito A....Kamatani N. (2009)
    4. Targeting, import, and dimerization of a mammalian mitochondrial ATP binding cassette (ABC) transporter, ABCB10 (ABC-me). (PubMed id 15215243)1, 2 Graf S.A....Shirihai O.S. (2004)
    5. Three hundred twenty-six genetic variations in genes encoding nine members of ATP-binding cassette, subfamily B (ABCB/MDR/TAP), in the Japanese population. (PubMed id 11829140)1, 2 Saito S.... Nakamura Y. (2002)
    6. M-ABC2, a new human mitochondrial ATP-binding cassette membrane protein. (PubMed id 10922475)1, 2 Zhang F....Ling V. (2000)
    7. ATP-binding cassette B10 regulates early steps of heme synthesis. (PubMed id 23720443)1 Bayeva M....Ardehali H. (2013)
    8. Structures of ABCB10, a human ATP-binding cassette tra nsporter in apo- and nucleotide-bound states. (PubMed id 23716676)1 Shintre C.A....Carpenter E.P. (2013)
    9. Genome-wide and gene-centric analyses of circulating m yeloperoxidase levels in the charge and care consortia. (PubMed id 23620142)1 Reiner A.P....Allayee H. (2013)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23456 HGNC: 41 AceView: ABCB10 Ensembl:ENSG00000135776 euGenes: HUgn23456
    ECgene: ABCB10 Kegg: 23456 H-InvDB: ABCB10

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ABCB10 Pharmacogenomics, SNPs, Pathways
    ABCMdbhttp://abcmutations.hegelab.org/proteinDetails?uniprot_id=Q9NRK6

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ABCB10 gene:
    Search GeneIP for patents involving ABCB10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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