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ABCB10 Gene

protein-coding   GIFtS: 57

GC01M227718
ATP-binding cassette, sub-family B (MDR/TAP), member 10
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases
EST20237 1, 2
M-ABC2 1, 2, 3
MTABC2 1, 2, 5
OTTHUMP00000037475 2
Descriptions
ABC transporter 10 protein 2, 3
ATP-binding cassette sub-family B member 10, mitochondrial 2
ATP-binding cassette transporter 10 2, 3
ATP-binding cassette, sub-family B (MDR/TAP), member 10 2
ATP-binding cassette, sub-family B, member 10 2
Mitochondrial ATP-binding cassette 2 2, 3
External Ids
HGNC: 411
Entrez Gene: 234562
UniProtKB: Q9NRK63
Ensembl: ENSG000001357767
Search outside databases for aliases for ABCB10 gene

Previous GC identifers: GC01M228099 GC01M225346 GC01M226051 GC01M226613 GC01M225959

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for ABCB10:
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding
cassette (ABC) transporters. ABC proteins transport various molecules across extra- and
intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP,
MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the
MDR/TAP subfamily are involved in multidrug resistance. The function of this mitochondrial protein
is unknown. [provided by RefSeq]

UniProtKB/Swiss-Prot: ABCBA_HUMAN, Q9NRK6
Function: May mediate critical mitochondrial transport functions related to heme biosynthesis (By
similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the ABCB10 gene  

Entrez Gene cytogenetic band: 1q42.13   Ensembl cytogenetic band:  1q42.13   HGNC cytogenetic band: 1q32

ABCB10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M227718:     (about GC identifiers)

Start:
227,718,953 bp from pter
End:
227,761,065 bp from pter
Size:
42,113 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000001.9  NT_004559.13  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: ABCBA_HUMAN, Q9NRK6 (See protein sequence)
Recommended Name: ATP-binding cassette sub-family B member 10, mitochondrial precursor  
Size: 738 amino acids; 79148 Da
Subunit: Homodimer or heterodimer (Potential)
Subcellular location: Mitochondrion inner membrane; Multi-pass membrane protein
Secondary accessions: Q13040 Q6P1Q8 Q9H3V0

REFSEQ proteins: NP_036221.2  

ENSEMBL proteins: 
ENSP00000355637 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich  
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Recombinant Proteins from Abcam (ABCB10)
Human Recombinant Proteins from Abnova (ABCB10)
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

5 Gene Ontology (GO) cellular component terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005739 mitochondrion IEA--
GO:0005743 mitochondrial inner membrane IEA--
GO:0016020 membrane IEA--
GO:0016021 integral to membrane IEA--
GO:0043190 ATP-binding cassette (ABC) transporter complex NAS10748049
About this table

Antibodies for ABCB10: 
Browse Antibodies Central at Invitrogen
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Browse Antibodies at Sigma-Aldrich
Browse R&D Systems for Antibodies
Antibodies from Abcam (ABCB10), each with their AbpromiseSM
Monoclonal and Polyclonal Antibodies from Abnova (ABCB10)
Novus Biologicals Antibody for ABCB10

Assays for ABCB10: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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5 InterPro domains/families:
 IPR003593 ATPase_AAA+_core
 IPR003439 ABC_transporter-like
 IPR017940 ABC_transporter_type1
 IPR001140 ABC_TM_transpt
 IPR017871 ABC_transporter_CS


   GeneDecks  ABCB10 for the domains selected above  
About GeneDecksing

Graphical View of Domain Structure for InterPro Entry Q9NRK6

ProtoNet protein and cluster: Q9NRK6

UniProtKB/Swiss-Prot: ABCBA_HUMAN, Q9NRK6
Similarity: Belongs to the ABC transporter family. Mitochondrial peptide exporter (TC 3.A.1.212)
subfamily
Similarity: Contains 1 ABC transmembrane type-1 domain
Similarity: Contains 1 ABC transporter domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (ABCB10)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (ABCB10)
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_012089

              Applied Biosystems Silencer® siRNAs for ABCB10

              Sigma-Aldrich siRNA and siRNA Panels for ABCB10  
                     Sigma-Aldrich shRNA for ABCB10  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Browse Clone Ranger at Invitrogen for clones
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_012089
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_012089
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_012089 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_012089

UniProtKB/Swiss-Prot: ABCBA_HUMAN, Q9NRK6
Function: May mediate critical mitochondrial transport functions related to heme biosynthesis (By
similarity)

Genatlas biochemistry entry for ABCB10:
ATP-binding cassette superfamily,sufamily B (MDR/TAP),member 10

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0000166 nucleotide binding IEA--
GO:0005524 ATP binding NAS10748049
GO:0016887 ATPase activity IEA--
GO:0042626 ATPase activity, coupled to transmembrane movement of substances IEA--
About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section


1 Kegg Pathway  (Kegg details for ABCB10):
 hsa02010 ABC transporters

   GeneDecks  ABCB10 for the pathways selected above  
About GeneDecksing

5/9 Interacting proteins for ABCB10 (ENSP000003556373) via UniProtKB, MINT, and/or STRING (see all 9 )
InteractantInteraction Details
GeneCardExternal ID(s)
ABCF2ENSP000002223883STRING (score=.965)
ABCA2ENSP000003472053STRING (score=.961)
ABCB8ENSP000002975043STRING (score=.94)
ABCB9ENSP000002805603STRING (score=.931)
ABCD4ENSP000003493963STRING (score=.926)
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1 Gene Ontology (GO) biological process term (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0006810 transport NAS10748049
About this table
(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for ABCB10

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (ABCB10)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (ABCB10)
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_012089

              Sigma-Aldrich siRNA and siRNA Panels for ABCB10  
                     Sigma-Aldrich shRNA for ABCB10  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_012089  

REFSEQ mRNAs for ABCB10 gene: 

NM_012089.2   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_012089  

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_012089
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_012089
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_012089 

Additional cDNA sequence: 

AB013380.1 AF216833.1 AF277184.1 AK172794.1 BC064930.1 DQ786241.1 U18237.1 

8 DOTS entries:

DT.99978524  DT.413314  DT.100727801  DT.40235154  DT.100782903  DT.100830974  DT.40106166  DT.95254945 

24/122 AceView cDNA sequences (see all 122 ):

CK906289 BX494345 AW264099 BM769842 BM718393 AI338028 AU124835 BM683451 
BX106160 AA045640 BM982301 BM126578 BX403383 BQ575633 BC064930 BQ022623 
BM126834 BQ023945 AA434506 BX507406 BQ229972 BX281688 AI472910 CA433072 

highest scoring ESTs for ABCB10:

AA306009 AI926482 AL552812 U18237 AB013380 AF216833 BC064930 BE247555 AA045640 AA045641 

Unigene Cluster for ABCB10:

ATP-binding cassette, sub-family B (MDR/TAP), member 10
Hs.17614  [show with all ESTs]
Unigene Representative Sequence: AB013380


GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:
ENST00000344517  
(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

ABCB10 expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for ABCB10

1 / 2 / 3

4 probe-sets matching ABCB10 gene


Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

59294_at2, 3 U95-C 1 1.00 1.00 1.00 1.00 AI926482 0.80 1.00 0.91 1

35458_r_at2, 3 U95-A 3 1.00 0.96 0.66 0.21 U18237 0.80 1.00 0.91 1

223320_s_at2, 3 U133-B 1 1.00 1.00 -- -- AF277184 0.60 1.00 0.82 1

223320_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
About this table
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: ATGTTCAATT

SOURCE GeneReport for Unigene cluster: Hs.17614

Expression variation in blood from EXPOLDB for ABCB10

UniProtKB/Swiss-Prot: ABCBA_HUMAN, Q9NRK6
Tissue specificity: Ubiquitous. Highly expressed in bone marrow, expressed at intermediate to high
levels in skeletal muscle, small intestine, thyroid, heart, brain, placenta, liver, pancreas,
prostate, testis, ovary, leukocyte, stomach, spinal cord, lymph node, trachea and adrenal gland,
and low levels are found in lung, kidney, spleen, thymus and colon

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section


Orthologs for ABCB10 gene from 5/24 species (see all 24 )
Organism Gene Locus Description Human
Similarity
NCBI accessions
cow
(Bos taurus)
ABCB101   -- ATP-binding cassette, sub-family B (MDR/TAP), member more 84.01(n)
84.14(a)
789800  XM_001256448.1  XP_001256449.1 
rat
(Rattus norvegicus)
Abcb101   -- ATP-binding cassette, sub-family B (MDR/TAP), member more 76.97(n)
77.83(a)
361439  NM_001012166.1  NP_001012166.1 
mouse
(Mus musculus)
Abcb101, 5 85
ATP-binding cassette, sub-family B (MDR/TAP), member more1, 5 78.69(n)1
80.15(a)1
561991  NM_019552.21  NP_062425.11 
 AF2662845  AK0811435  (see all 16)
chicken
(Gallus gallus)
ABCB101   -- ATP-binding cassette, sub-family B (MDR/TAP), member more 75.85(n)
81.98(a)
421537  XM_419578.2  XP_419578.2 
zebrafish
(Danio rerio)
LOC1000037441   -- similar to ATP-binding cassette sub-family B member more 66.38(n)
71.01(a)
100003744  XM_001343182.2  XP_001343218.2 
About this table        Species with no ortholog for ABCB10

ENSEMBL Gene Tree for ABCB10
(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

Paralogs for ABCB10 gene
ABCB92  ENSG000002201072  

Pseudogenes
2 related pseudogenes


(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10/273 NCBI SNPs in ABCB10 are shown (see all 273 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 73)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 1 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
------------
rs10535131,2
A,C,F,H227719210(-) TGAATA/GTAGTG 1 -- ut31 ese39Minor allele frequency- G:0.21MN EA NA EU WA 766
rs10535121,2
A,C,F227719321(-) CTAAGC/AATTTA 1 -- ut311Minor allele frequency- A:0.11MN 184
rs127331,2
C,O227719186(-) TAAACA/GGTACA 1 -- ut311Minor allele frequency- G:0.00MN 184
rs356987971,2
C,F227732581(+) AGGGTC/TGTACA 1 D/N mis15Minor allele frequency- T:0.01NA EU EA WA 494
rs175846421,2
H227750066(+) AATGCG/CCTGAC 1 G/R mis1 ese37Minor allele frequency- C:0.00NA EU EA WA 534
--
rs121291351,2
A227762310(+) ATGGGA/TTCACA 1 -- ng310--------
rs37381871,2
A,C,F,H227749887(+) CCTACG/AGAAGC 1 S/S syn19Minor allele frequency- A:0.19EA NA EU WA 2120
rs120808111,2
C,F227751785(+) GACATC/TGTGAG 1 T/T syn1 ese31Minor allele frequency- T:0.03NA 76
rs9272041,2
A,C,F,H,O227747629(+) CTCTTC/TCAGAG 1 -- int119Minor allele frequency- T:0.22NA EA EU WA 1654
rs3483301,2
A,C,F,H227739578(-) tagttC/Tccaaa 1 -- int17Minor allele frequency- N:0.00EA WA NA 512
About this table

HapMap Linkage Disequilibrium images for ABCB10 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 605454

Human Genome Epidemiology Navigator: ABCB10 (1 document)

(Possibly Related Articles in Doctor's Guide)
About This Section

  --

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

10/11 PubMed articles for ABCB10 gene (see all 11 ):
(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)
(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 23456 HGNC: 41 AceView: ABCB10 Ensembl:ENSG00000135776 euGenes: HUgn23456
ECgene: ABCB10 H-InvDB: ABCB10
(According to HUGE)
About This Section

  --
(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

  --
(Available from WIS Yeda, Salk, Tufts)
About This Section

  --
(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for ABCB10:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



  Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
  Invitrogen Antibodies  Invitrogen Assays
  Invitrogen Clones  Invitrogen Q-PCR Products
  Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
  Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for ABCB10-related products

 Millipore Custom Antibody & Bulk Services
 Millipore Preclinical / Clinical Development Services
 Millipore Immunoassay Services
 Millipore Target Screening & Profiling Services


 Predesigned and custom siRNAs for ABCB10 Browse antibodies at Sigma-Aldrich
 Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
 Lentivirus-delivered shRNAs for ABCB10 Browse small molecules at Sigma-Aldrich
 "Your Favorite Gene" Pathwaysfeedback


  
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 Recombinant & Natural Proteins  

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 Recombinant Proteins
(ABCB10)
 Antibodies (ABCB10)
 Search OriGene for ABCB10
 Search Tocris compounds for ABCB10




 Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
 Antibodies for ABCB10

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