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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ABCB10 Gene

protein-coding   GIFtS: 57
GCID: GC01M229652

ATP-binding cassette, sub-family B (MDR/TAP), member 10
 Explore 10 diseases affiliated with
ABCB10 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ABCB10    

Aliases
for ABCB10 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 101 2     ABC Transporter 10 Protein2 3
M-ABC21 2 3     ATP-Binding Cassette Transporter 102 3
MTABC21 2 5     ATP-Binding Cassette Sub-Family B Member 10, Mitochondrial2
EST202371 2     EC 3.6.38
Mitochondrial ATP-Binding Cassette 22 3     EC 3.6.3.448

External Ids:    HGNC: 411   Entrez Gene: 234562   Ensembl: ENSG000001357767   OMIM: 6054545   UniProtKB: Q9NRK63   

Export aliases for ABCB10 gene to outside databases

Previous GC identifers: GC01M228099 GC01M225346 GC01M226051 GC01M226613 GC01M225959 GC01M227718 GC01M200142


Summaries
for ABCB10 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ABCB10:
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC)
transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are
divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the
MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The function of this
mitochondrial protein is unknown. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: ABCBA_HUMAN, Q9NRK6
Function: May mediate critical mitochondrial transport functions related to heme biosynthesis (By similarity)




Genomic Views
for ABCB10 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_167186.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ABCB10 gene promoter:
         TBP   Nkx3-1   Nkx3-1 v4   Pbx1a   AML1a   Nkx3-1 v1   YY1   Nkx3-1 v2   TFIID   Nkx3-1 v3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ABCB10 promoter sequence
   Search SABiosciences Chromatin IP Primers for ABCB10

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ABCB10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q42.13   Ensembl cytogenetic band:  1q42.13   HGNC cytogenetic band: 1q32

ABCB10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ABCB10 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M229652:  view genomic region     (about GC identifiers)

Start:
 229,652,329 bp from pter      End:
 229,694,442 bp from pter
Size:
 42,114 bases      Orientation:
 minus strand

Proteins
for ABCB10 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ABCBA_HUMAN, Q9NRK6 (See protein sequence)
Recommended Name: ATP-binding cassette sub-family B member 10, mitochondrial precursor  
Size: 738 amino acids; 79148 Da
Subunit: Homodimer or homooligomer
Subcellular location: Mitochondrion inner membrane; Multi-pass membrane protein
4 PDB 3D structures from and Proteopedia for ABCB10:
3ZDQ (3D)        4AYT (3D)        4AYW (3D)        4AYX (3D)    
Secondary accessions: Q13040 Q6P1Q8 Q9H3V0

Explore the universe of human proteins at neXtProt for ABCB10: NX_Q9NRK6

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9NRK6

    • 4/5 DME Specific Peptides for ABCB10 (Q9NRK6) (see all 5)
     AHRLSTI  KILLLDE  QRIAIARA  VIAHRLST 

    ABCB10 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_036221.2  
    ENSEMBL proteins: 
     ENSP00000355637  
    Reactome Protein details: Q9NRK6
    Human Recombinant Protein Products: 
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    OriGene Protein Over-expression Lysate: ABCB10
    OriGene Custom Protein Services for ABCB10 
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    Novus Biologicals ABCB10 Protein
    Novus Biologicals ABCB10 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for ABCB10

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion ----
    GO:0005743mitochondrial inner membrane IBA--
    GO:0005886NOT plasma membrane IRD--
    GO:0032592integral to mitochondrial membrane IDA10922475


    ABCB10 for ontologies           About GeneDecksing



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    Uscn Antibodies for ABCB10
    Search ThermoFisher Antibodies for ABCB10

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    Uscn ELISAs and CLIAs for ABCB10

    Protein Domains /
    Families
    for ABCB10 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ABCB10 for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR003439 ABC_transporter-like
     IPR001140 ABC_transptr_TM_dom
     IPR003593 AAA+_ATPase
     IPR017940 ABC_transporter_type1
     IPR011527 ABC_transptrTM_dom_typ1

    Graphical View of Domain Structure for InterPro Entry Q9NRK6

    ProtoNet protein and cluster: Q9NRK6

    UniProtKB/Swiss-Prot: ABCBA_HUMAN, Q9NRK6
    Similarity: Belongs to the ABC transporter superfamily. ABCB family. Mitochondrial peptide exporter (TC 3.A.1.212)
    subfamily
    Similarity: Contains 1 ABC transmembrane type-1 domain
    Similarity: Contains 1 ABC transporter domain


    Function
    for ABCB10 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: ABCBA_HUMAN, Q9NRK6
    Function: May mediate critical mitochondrial transport functions related to heme biosynthesis (By similarity)

         Genatlas biochemistry entry for ABCB10:
    ATP-binding cassette superfamily,sufamily B (MDR/TAP),member 10

    Enzyme Numbers (IUBMB): EC 3.6.3.442 EC 3.6.32

    miRNA
    Products:            		 OriGene 3'-UTR Clone: ABCB10
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ABCB10
    8/21 QIAGEN miScript miRNA Assays for microRNAs that regulate ABCB10 (see all 21):
    hsa-miR-140-5p hsa-miR-579 hsa-miR-607 hsa-miR-128 hsa-miR-219-5p hsa-miR-1323 hsa-miR-3148 hsa-miR-3163
    SwitchGear 3'UTR luciferase reporter plasmid: ABCB10 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ABCB10 (see all 7)
    OriGene shRNA RFP: ABCB10
    OriGene siRNA: ABCB10
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ABCB10

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for ABCB10

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ABCB10 (see all 4)
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: ABCB10 (NM_012089)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ABCB10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ABCB10 

    Cell Line
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    Search LifeMap BioReagents cell lines for ABCB10

    In Situ Assay
    Products:       
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    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005215transporter activity NAS10922475
    GO:0005524ATP binding IEA--
    GO:0015421oligopeptide-transporting ATPase activity IBA--
    GO:0042803protein homodimerization activity IEA--


    ABCB10 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for ABCB10:
     Decreased influenza A/WSN/33 r  Increased cell death HMECs cel 

    Animal Models:
         4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Abcb10):
     cardiovascular system  cellular  homeostasis/metabolism  mortality/aging 

    ABCB10 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for ABCB10 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1ABC-family proteins mediated transport
    		ABC-family proteins mediated transport1.00
    		ABC transporters0.70
    2Mitochondrial ABC transporters
    		Mitochondrial ABC transporters1.00
    3SLC-mediated transmembrane transport
    		Transmembrane transport of small molecules0.50

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    3        Reactome Pathways for ABCB10
        ABC-family proteins mediated transport
    Transmembrane transport of small molecules
    Mitochondrial ABC transporters


    1         Kegg Pathway  (Kegg details for ABCB10):
        ABC transporters


    ABCB10 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ABCB10

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    5/26 Interacting proteins for ABCB10 (Q9NRK63 ENSP000003556374) via UniProtKB, MINT, STRING, and/or I2D (see all 26)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ABCB7O750273I2D: score=1 
    CNBPP626333I2D: score=1 
    CRLS1Q9UJA23I2D: score=1 
    FZR1Q9UM113I2D: score=1 
    HSPA9P386463I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport NAS10922475
    GO:0055085transmembrane transport IBA--


    ABCB10 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ABCB10 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ABCB10

    1 HMDB Compound for ABCB10    About this table
    CompoundSynonyms CAS #PubMed Ids
    Heme(protoporphyrinato)iron (see all 19)14875-96-8--
    Search CenterWatch for drugs/clinical trials and news about ABCB10 / ABCBA 

    Transcripts
    for ABCB10 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ABCB10 gene: 
    NM_012089.2  

    Unigene Cluster for ABCB10:

    ATP-binding cassette, sub-family B (MDR/TAP), member 10
    Hs.17614  [show with all ESTs]
    Unigene Representative Sequence: AB013380
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000344517(uc001htp.4) ENST00000498158 ENST00000486755

    miRNA
    Products:             		 OriGene 3'-UTR Clone: ABCB10
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ABCB10
    8/21 QIAGEN miScript miRNA Assays for microRNAs that regulate ABCB10 (see all 21):
    hsa-miR-140-5p hsa-miR-579 hsa-miR-607 hsa-miR-128 hsa-miR-219-5p hsa-miR-1323 hsa-miR-3148 hsa-miR-3163
    SwitchGear 3'UTR luciferase reporter plasmid: ABCB10 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ABCB10 (see all 7)
    OriGene shRNA RFP: ABCB10
    OriGene siRNA: ABCB10
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ABCB10
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ABCB10 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ABCB10 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: ABCB10 (NM_012089)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ABCB10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ABCB10 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ABCB10
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ABCB10
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ABCB10
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ABCB10

    Additional cDNA sequence: 

    AB013380.1 AF216833.1 AF277184.1 AK172794.1 BC064930.1 DQ786241.1 U18237.1 

    8 DOTS entries:

    DT.99978524  DT.413314  DT.100727801  DT.100782903  DT.100830974  DT.40106166  DT.40235154  DT.95254945 

    24/122 AceView cDNA sequences (see all 122):

    BQ575633 BQ023945 BC064930 BM769842 BM126578 AI472910 AU124835 BQ022623 
    BX106160 AA045640 H28322 BX507406 AA434506 BX281688 BM718393 BM126834 
    AI338028 BX494345 BM683451 AW264099 CK906289 BM982301 CA433072 BQ229972 

    GeneLoc Exon Structure


    Expression
    for ABCB10 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ABCB10 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ATGTTCAATT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    ABCB10 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    HeartCardiac CrescentCardiac Crescent CellsMyocardium
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See ABCB10 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ABCB10

    SOURCE GeneReport for Unigene cluster: Hs.17614

    UniProtKB/Swiss-Prot: ABCBA_HUMAN, Q9NRK6
    Tissue specificity: Ubiquitous. Highly expressed in bone marrow, expressed at intermediate to high levels in skeletal
    muscle, small intestine, thyroid, heart, brain, placenta, liver, pancreas, prostate, testis, ovary, leukocyte,
    stomach, spinal cord, lymph node, trachea and adrenal gland, and low levels are found in lung, kidney, spleen, thymus
    and colon

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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ABCB10

    Orthologs
    for ABCB10 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ABCB10 gene from 9/34 species (see all 34)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves ABCB101 ATP-binding cassette, sub-family B (MDR/TAP), member more 75.85(n)
    82.16(a)    		   421537  XM_419578.2  XP_419578.2 
    lizard
    (Anolis carolinensis)    		 Reptilia ABCB106
    		 --
    		 78(a)
    		 1 ↔ 1
    		 1(222273426-222302502)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.153412 Xenopus laevis transcribed sequence with moderate similarity more 77.01(n)    BJ045453.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii abcb101 ATP-binding cassette, sub-family B (MDR/TAP), member more 66.38(n)
    71.01(a)    		   100003744  XM_001343182.4  XP_001343218.2 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG102263
    CG31561    		 multidrug transporter3
    CG31561    		 58(a)
    (best of 2)3
    53.98(n)1
    50.51(a)1    		   65A103
    309941  NM_130488.21  NP_569844.21 
    worm
    (Caenorhabditis elegans)    		 Secernentea haf-31 Protein HAF-3 50.46(n)
    45.52(a)    		   180056  NM_074526.5  NP_506927.2 
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes MDL1(YLR188W)4
    MDL11    		 Mitochondrial inner membrane half-type ATP-binding more4
    Mdl1p1    		 48.07(n)1
    44.21(a)1    		   12(528300-530387)4
    8508851, 4  NP_013289.11, 4 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons TAP21 ABC transporter B family member 27 49.77(n)
    44.73(a)    		   833896  NM_123266.7  NP_198720.2 
    rice
    (Oryza sativa)    		 Liliopsida Os.92202 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 74.55(n)    AK069342.1 


    ENSEMBL Gene Tree for ABCB10 (if available)
    TreeFam Gene Tree for ABCB10 (if available) 

    Paralogs
    for ABCB10 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ABCB10 gene
    TAP22  ENSG000002502642  TAP12  ABCB92  ABCB82  
    8 SIMAP similar genes for ABCB10 using alignment to 1 protein entry:     ABCBA_HUMAN:
    ABCB4    ABCB8    ABCB11    ABCB9    ABCB1    ABCB5
    TAP1    TAP2

    ABCB10 for paralogs           About GeneDecksing


    5 Pseudogenes.org Pseudogenes for ABCB10
    PGOHUM00000246654 PGOHUM00000246689 PGOHUM00000247024 PGOHUM00000260648 PGOHUM00000260659


    Genomic Variants
    for ABCB10 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/762 NCBI SNPs in ABCB10 are shown (see all 762)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1143220891,2
    		--229651829(+) TAAATT/CACAGG 1 -- ds50011Minor allele frequency- C:0.01WA 118
    rs1835349901,2
    		--229651868(+) AACACG/TCTGGA 1 -- ds50010--------
    rs1391061071,2
    		--229652040(+) AGTTCA/CTTGTC 1 -- ds50010--------
    rs1885343841,2
    		--229652041(+) GTTCCC/TTGTCC 1 -- ds50010--------
    rs1927767901,2
    		--229652071(+) CTTATG/TTACTG 1 -- ds50010--------
    rs1848093341,2
    		--229652089(+) ACAATG/TAAACA 1 -- ds50010--------
    rs561446961,2
    		C--229652389(+) TGAACA/GTCATG 1 -- ut310--------
    rs1430919331,2
    		--229652450(+) TGGCAC/TAAGGA 1 -- ut310--------
    rs1869750101,2
    		--229652475(+) TTCAAC/TCTTGT 1 -- ut310--------
    rs1474905791,2
    		--229652530(+) CAAGTA/GGAGCT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for ABCB10 (229652329 - 229694442 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for ABCB10
         1 Indel: 71375

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    Disorders / Diseases
    for ABCB10 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ABCB10 for disorders           About GeneDecksing

    OMIM gene information: 605454    OMIM disorders: --

    10 diseases for ABCB10:    About MalaCards
    wegener-like granulomatosis    bare lymphocyte syndrome    acute myeloid leukemia    myeloid leukemia
    leukemia    pneumonia    tuberculosis    thyroiditis
    prostatitis    mycobacterium tuberculosis

    Human Genome Epidemiology (HuGE) Navigator: ABCB10 (2 documents)

    Export disorders for ABCB10 gene to outside databases

    Publications
    for ABCB10 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ABCB10 gene, integrated from 9 sources (see all 19):
    (articles sorted by number of sources associating them with ABCB10)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization and mapping of three new mammalian ATP-binding transporter genes from an EST database. (PubMed id 7766993)1, 2, 3 Allikmets R.... Dean M. (1995)
    2. Targeting, import, and dimerization of a mammalian mitochondrial ATP binding cassette (ABC) transporter, ABCB10 (ABC-me). (PubMed id 15215243)1, 2 Graf S.A....Shirihai O.S. (2004)
    3. Three hundred twenty-six genetic variations in genes encoding nine members of ATP-binding cassette, subfamily B (ABCB/MDR/TAP), in the Japanese population. (PubMed id 11829140)1, 2 Saito S.... Nakamura Y. (2002)
    4. M-ABC2, a new human mitochondrial ATP-binding cassette membrane protein. (PubMed id 10922475)1, 2 Zhang F....Ling V. (2000)
    5. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    6. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    7. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    8. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    9. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (2010)
    10. Lysine acetylation targets protein complexes and co-regulates major cellular functions. (PubMed id 19608861)2 Choudhary C.... Mann M. (2009)

    External Searches for ABCB10 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
    		PubMed
    OMIM
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    Genome Databases showing ABCB10 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23456 HGNC: 41 AceView: ABCB10 Ensembl:ENSG00000135776 euGenes: HUgn23456
    ECgene: ABCB10 Kegg: 23456 H-InvDB: ABCB10

    Other Databases showing ABCB10 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ABCB10 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ABCB10 Pharmacogenomics, SNPs, Pathways
    ABCMdbhttp://abcmutations.hegelab.org/proteinDetails?uniprot_id=Q9NRK6

    Intellectual Property
    for ABCB10 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ABCB10 gene:
    Search GeneIP for patents involving ABCB10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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