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Aliases & Descriptions for ABCB10
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| EST20237 1, 2 | | M-ABC2 1, 2, 3 | | MTABC2 1, 2, 5 | | OTTHUMP00000037475 2 |
| | | Descriptions |
|---|
| ABC transporter 10 protein 2, 3 | | ATP-binding cassette sub-family B member 10, mitochondrial 2 | | ATP-binding cassette transporter 10 2, 3 | | ATP-binding cassette, sub-family B (MDR/TAP), member 10 2 | | ATP-binding cassette, sub-family B, member 10 2 | | Mitochondrial ATP-binding cassette 2 2, 3 |
|
| | Search outside databases for aliases for ABCB10 genePrevious GC identifers: GC01M228099 GC01M225346 GC01M226051 GC01M226613 GC01M225959 |
Summaries for ABCB10(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for ABCB10: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The function of this mitochondrial protein is unknown. [provided by RefSeq] UniProtKB/Swiss-Prot: ABCBA_HUMAN, Q9NRK6Function: May mediate critical mitochondrial transport functions related to heme biosynthesis (By similarity) |
Genomic Location for ABCB10
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the ABCB10 gene 
Entrez Gene cytogenetic band: 1q42.13 Ensembl cytogenetic band: 1q42.13 HGNC cytogenetic band: 1q32ABCB10 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M227718:
(about GC identifiers)
Start:
|
227,718,953 bp from pter |
End:
|
227,761,065 bp from pter |
Size:
|
42,113 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000001.9 NT_004559.13
| Proteins for ABCB10
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: ABCBA_HUMAN, Q9NRK6 (See
protein sequence)Recommended Name: ATP-binding cassette sub-family B member 10, mitochondrial precursor Size: 738 amino acids; 79148 Da
Subunit: Homodimer or heterodimer (Potential)
Subcellular location: Mitochondrion inner membrane; Multi-pass membrane protein
Secondary accessions: Q13040 Q6P1Q8 Q9H3V0REFSEQ proteins: NP_036221.2
ENSEMBL proteins: ENSP00000355637
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
5 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for ABCB10: Assays for ABCB10: | Protein
Domains/ Families for ABCB10(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q9NRK6
ProtoNet protein and cluster: Q9NRK6 UniProtKB/Swiss-Prot: ABCBA_HUMAN, Q9NRK6Similarity: Belongs to the ABC transporter family. Mitochondrial peptide exporter (TC 3.A.1.212) subfamilySimilarity: Contains 1 ABC transmembrane type-1 domainSimilarity: Contains 1 ABC transporter domain | Gene Function for ABCB10
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_012089
Applied Biosystems Silencer® siRNAs for ABCB10
Sigma-Aldrich siRNA and siRNA Panels for ABCB10  Sigma-Aldrich shRNA for ABCB10  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_012089                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_012089                                  untagged cDNA clones in CMV expression vector (see all 2): NM_012089 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_012089
UniProtKB/Swiss-Prot: ABCBA_HUMAN, Q9NRK6Function: May mediate critical mitochondrial transport functions related to heme biosynthesis (By similarity)Genatlas biochemistry entry for ABCB10:ATP-binding cassette superfamily,sufamily B (MDR/TAP),member 104 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for ABCB10
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
5/9 Interacting proteins for ABCB10 (ENSP000003556373) via UniProtKB, MINT, and/or STRING (see all 9
)About this table
1 Gene Ontology (GO) biological process term (links to tree view): About this table
|
Drugs & Compounds for ABCB10(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for ABCB10
|
Transcripts for ABCB10(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_012089
Sigma-Aldrich siRNA and siRNA Panels for ABCB10  Sigma-Aldrich shRNA for ABCB10  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_012089 REFSEQ mRNAs for ABCB10 gene: NM_012089.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_012089               OriGene GFP tagged cDNA clone in CMV expression vector: NM_012089                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_012089                                  untagged cDNA clones in CMV expression vector (see all 2): NM_012089  Additional cDNA sequence: AB013380.1 AF216833.1 AF277184.1 AK172794.1 BC064930.1 DQ786241.1 U18237.1 8 DOTS entries: DT.99978524 DT.413314 DT.100727801 DT.40235154 DT.100782903 DT.100830974 DT.40106166 DT.95254945 24/122 AceView cDNA sequences (see all 122
):CK906289 BX494345 AW264099 BM769842 BM718393 AI338028 AU124835 BM683451 BX106160 AA045640 BM982301 BM126578 BX403383 BQ575633 BC064930 BQ022623 BM126834 BQ023945 AA434506 BX507406 BQ229972 BX281688 AI472910 CA433072
highest scoring ESTs for ABCB10:AA306009 AI926482 AL552812 U18237 AB013380 AF216833 BC064930 BE247555 AA045640 AA045641 Unigene Cluster for ABCB10: ATP-binding cassette, sub-family B (MDR/TAP), member 10 Hs.17614 [show with all ESTs]Unigene Representative Sequence: AB013380
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation: ENST00000344517
|
Expression for ABCB10
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| ABCB10 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for ABCB10
1 / 2 / 3 4 probe-sets matching ABCB10 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: ATGTTCAATT
SOURCE GeneReport for Unigene cluster: Hs.17614
Expression variation in blood from EXPOLDB for ABCB10 UniProtKB/Swiss-Prot: ABCBA_HUMAN, Q9NRK6Tissue specificity: Ubiquitous. Highly expressed in bone marrow, expressed at intermediate to high levels in skeletal muscle, small intestine, thyroid, heart, brain, placenta, liver, pancreas, prostate, testis, ovary, leukocyte, stomach, spinal cord, lymph node, trachea and adrenal gland, and low levels are found in lung, kidney, spleen, thymus and colon |
Orthologs for ABCB10
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for ABCB10 gene from 5/24 species (see all 24
)
| Organism |
Gene |
Locus |
Description |
Human Similarity |
NCBI accessions |
cow (Bos taurus) |
ABCB101 |
-- |
ATP-binding cassette, sub-family B (MDR/TAP), member more |
84.01(n) 84.14(a) |
789800 XM_001256448.1 XP_001256449.1 |
rat (Rattus norvegicus) |
Abcb101 |
-- |
ATP-binding cassette, sub-family B (MDR/TAP), member more |
76.97(n) 77.83(a) |
361439 NM_001012166.1 NP_001012166.1 |
mouse (Mus musculus) |
Abcb101, 5 |
85
|
ATP-binding cassette, sub-family B (MDR/TAP), member more1, 5 |
78.69(n)1 80.15(a)1 |
561991 NM_019552.21 NP_062425.11 AF2662845 AK0811435 (see all 16) |
chicken (Gallus gallus) |
ABCB101 |
-- |
ATP-binding cassette, sub-family B (MDR/TAP), member more |
75.85(n) 81.98(a) |
421537 XM_419578.2 XP_419578.2 |
zebrafish (Danio rerio) |
LOC1000037441 |
-- |
similar to ATP-binding cassette sub-family B member more |
66.38(n) 71.01(a) |
100003744 XM_001343182.2 XP_001343218.2 |
About this table Species with no ortholog for ABCB10
ENSEMBL Gene Tree for ABCB10 | Paralogs for ABCB10(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for ABCB10 gene
- ABCB92 ENSG000002201072
Pseudogenes
- 2 related pseudogenes
|
SNPs/Variants for ABCB10(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for ABCB10 (up to first 250kb)
|
Disorders & Mutations for ABCB10
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 605454
Human Genome Epidemiology Navigator: ABCB10 (1 document)
|
Medical News for ABCB10(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for ABCB10 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/11 PubMed articles for ABCB10 gene (see all 11
):- Characterization and mapping of three new mammalian ATP-binding transporter genes from an EST database. (PubMed id 7766993)2, 3, 4 Allikmets R.... Dean M. (1995)
- Three hundred twenty-six genetic variations in genes encoding nine members of ATP-binding cassette, subfamily B (ABCB/MDR/TAP), in the Japanese population. (PubMed id 11829140)3, 4 Saito S.... Nakamura Y. (2002)
- M-ABC2, a new human mitochondrial ATP-binding cassette membrane protein. (PubMed id 10922475)3, 4 Zhang F....Ling V. (2000)
- Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects. (PubMed id 19343046)3 Saito A....Kamatani N. (2009)
- The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)4 Sjoeblom T.... Velculescu V.E. (2006)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)4 Gregory S.G.... Bentley D.R. (2006)
- Targeting, import, and dimerization of a mammalian mitochondrial ATP binding cassette (ABC) transporter, ABCB10 (ABC-me). (PubMed id 15215243)3 Graf S.A....Shirihai O.S. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)4 Gerhard D.S....Malek J. (2004)
- Lineage-specific gene duplication and loss in human and great ape evolution. (PubMed id 15252450)3 Fortna A....Sikela J.M. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)3 Strausberg R.L....Marra M.A. (2002)
|
Search for ABCB10
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing ABCB10
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing ABCB10
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ABCB10(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for ABCB10(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for ABCB10:

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Incremental update: 13 Oct 2009
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