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Aliases for ABCB10 Gene

Aliases for ABCB10 Gene

  • ATP Binding Cassette Subfamily B Member 10 2 3 5
  • Mitochondrial ATP-Binding Cassette 2 2 3 4
  • ATP-Binding Cassette Transporter 10 2 3 4
  • ABC Transporter 10 Protein 2 3 4
  • ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 10 2 3
  • M-ABC2 3 4
  • ATP-Binding Cassette Sub-Family B Member 10 2
  • Mitochondrial 2
  • EC 3.6.3.44 63
  • EST20237 3
  • EC 3.6.3 63
  • MTABC2 3

External Ids for ABCB10 Gene

Previous GeneCards Identifiers for ABCB10 Gene

  • GC01M228099
  • GC01M225346
  • GC01M226051
  • GC01M226613
  • GC01M225959
  • GC01M227718
  • GC01M229652
  • GC01M200142

Summaries for ABCB10 Gene

Entrez Gene Summary for ABCB10 Gene

  • The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The function of this mitochondrial protein is unknown. [provided by RefSeq, Jul 2008]

GeneCards Summary for ABCB10 Gene

ABCB10 (ATP Binding Cassette Subfamily B Member 10) is a Protein Coding gene. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and ABC-family proteins mediated transport. GO annotations related to this gene include protein homodimerization activity and ATPase activity. An important paralog of this gene is TAP1.

UniProtKB/Swiss-Prot for ABCB10 Gene

  • May mediate critical mitochondrial transport functions related to heme biosynthesis.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ABCB10 Gene

Genomics for ABCB10 Gene

Regulatory Elements for ABCB10 Gene

Promoters for ABCB10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ABCB10 on UCSC Golden Path with GeneCards custom track

Genomic Location for ABCB10 Gene

Chromosome:
1
Start:
229,516,582 bp from pter
End:
229,558,695 bp from pter
Size:
42,114 bases
Orientation:
Minus strand

Genomic View for ABCB10 Gene

Genes around ABCB10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ABCB10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ABCB10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ABCB10 Gene

Proteins for ABCB10 Gene

  • Protein details for ABCB10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NRK6-ABCBA_HUMAN
    Recommended name:
    ATP-binding cassette sub-family B member 10, mitochondrial
    Protein Accession:
    Q9NRK6
    Secondary Accessions:
    • Q13040
    • Q6P1Q8
    • Q9H3V0

    Protein attributes for ABCB10 Gene

    Size:
    738 amino acids
    Molecular mass:
    79148 Da
    Quaternary structure:
    • Homodimer or homooligomer.

    Three dimensional structures from OCA and Proteopedia for ABCB10 Gene

neXtProt entry for ABCB10 Gene

Proteomics data for ABCB10 Gene at MOPED

Selected DME Specific Peptides for ABCB10 Gene

Post-translational modifications for ABCB10 Gene

  • Ubiquitination at Lys 159
  • Modification sites at PhosphoSitePlus

Other Protein References for ABCB10 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Domains & Families for ABCB10 Gene

Gene Families for ABCB10 Gene

Protein Domains for ABCB10 Gene

Suggested Antigen Peptide Sequences for ABCB10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NRK6

UniProtKB/Swiss-Prot:

ABCBA_HUMAN :
  • Contains 1 ABC transmembrane type-1 domain.
  • Belongs to the ABC transporter superfamily. ABCB family. Mitochondrial peptide exporter (TC 3.A.1.212) subfamily.
Domain:
  • Contains 1 ABC transmembrane type-1 domain.
  • Contains 1 ABC transporter domain.
Family:
  • Belongs to the ABC transporter superfamily. ABCB family. Mitochondrial peptide exporter (TC 3.A.1.212) subfamily.
genes like me logo Genes that share domains with ABCB10: view

Function for ABCB10 Gene

Molecular function for ABCB10 Gene

GENATLAS Biochemistry:
ATP-binding cassette superfamily,sufamily B (MDR/TAP),member 10
UniProtKB/Swiss-Prot Function:
May mediate critical mitochondrial transport functions related to heme biosynthesis.

Enzyme Numbers (IUBMB) for ABCB10 Gene

Gene Ontology (GO) - Molecular Function for ABCB10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
GO:0016887 ATPase activity IEA --
GO:0042803 protein homodimerization activity IEA --
genes like me logo Genes that share ontologies with ABCB10: view
genes like me logo Genes that share phenotypes with ABCB10: view

Animal Models for ABCB10 Gene

MGI Knock Outs for ABCB10:

Animal Model Products

miRNA for ABCB10 Gene

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ABCB10 Gene

Localization for ABCB10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ABCB10 Gene

Mitochondrion inner membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ABCB10 Gene COMPARTMENTS Subcellular localization image for ABCB10 gene
Compartment Confidence
mitochondrion 5
plasma membrane 3
cytosol 1
endoplasmic reticulum 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for ABCB10 Gene

Pathways & Interactions for ABCB10 Gene

genes like me logo Genes that share pathways with ABCB10: view

Pathways by source for ABCB10 Gene

Gene Ontology (GO) - Biological Process for ABCB10 Gene

None

No data available for SIGNOR curated interactions for ABCB10 Gene

Drugs & Compounds for ABCB10 Gene

(1) Drugs for ABCB10 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
heme Pharma Agonist 0
genes like me logo Genes that share compounds with ABCB10: view

Transcripts for ABCB10 Gene

Unigene Clusters for ABCB10 Gene

ATP-binding cassette, sub-family B (MDR/TAP), member 10:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ABCB10 Gene

No ASD Table

Relevant External Links for ABCB10 Gene

GeneLoc Exon Structure for
ABCB10
ECgene alternative splicing isoforms for
ABCB10

Expression for ABCB10 Gene

mRNA expression in normal human tissues for ABCB10 Gene

Protein differential expression in normal tissues from HIPED for ABCB10 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (15.7), Lung (10.6), Fetal Liver (8.1), and Colon muscle (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ABCB10 Gene



SOURCE GeneReport for Unigene cluster for ABCB10 Gene Hs.17614

mRNA Expression by UniProt/SwissProt for ABCB10 Gene

Q9NRK6-ABCBA_HUMAN
Tissue specificity: Ubiquitous. Highly expressed in bone marrow, expressed at intermediate to high levels in skeletal muscle, small intestine, thyroid, heart, brain, placenta, liver, pancreas, prostate, testis, ovary, leukocyte, stomach, spinal cord, lymph node, trachea and adrenal gland, and low levels are found in lung, kidney, spleen, thymus and colon.
genes like me logo Genes that share expression patterns with ABCB10: view

Protein tissue co-expression partners for ABCB10 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ABCB10 Gene

Orthologs for ABCB10 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ABCB10 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ABCB10 35
  • 86.13 (n)
  • 88.16 (a)
ABCB10 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ABCB10 35
  • 89.35 (n)
  • 92.51 (a)
ABCB10 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Abcb10 35
  • 80.01 (n)
  • 82.1 (a)
Abcb10 16
Abcb10 36
  • 76 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ABCB10 35
  • 99.12 (n)
  • 99.02 (a)
ABCB10 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Abcb10 35
  • 79.3 (n)
  • 81.92 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia ABCB10 36
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves ABCB10 35
  • 75.7 (n)
  • 82.22 (a)
ABCB10 36
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ABCB10 36
  • 78 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.15341 35
zebrafish
(Danio rerio)
Actinopterygii abcb10 35
  • 66.16 (n)
  • 70.56 (a)
abcb10 36
  • 60 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG10226 37
  • 58 (a)
EG:171D11.2 37
  • 48 (a)
CG3156 35
  • 53.98 (n)
  • 50.51 (a)
CG3156 36
  • 44 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002717 35
  • 51.81 (n)
  • 49.22 (a)
worm
(Caenorhabditis elegans)
Secernentea haf-3 35
  • 50.46 (n)
  • 45.52 (a)
haf-1 36
  • 35 (a)
ManyToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACR022W 35
  • 47.97 (n)
  • 41.02 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D00748g 35
  • 48.69 (n)
  • 41.71 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MDL2 35
  • 47.81 (n)
  • 41.25 (a)
MDL1 36
  • 37 (a)
ManyToMany
MDL2 36
  • 31 (a)
ManyToMany
MDL1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons TAP2 35
  • 50.2 (n)
  • 45.18 (a)
soybean
(Glycine max)
eudicotyledons Gma.4067 35
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.176 35
rice
(Oryza sativa)
Liliopsida Os.9220 35
Os03g0755100 35
  • 48.92 (n)
  • 44.48 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.2793 35
barley
(Hordeum vulgare)
Liliopsida Hv.625 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.13678 35
bread mold
(Neurospora crassa)
Ascomycetes NCU04117 35
  • 51.42 (n)
  • 47.13 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes mdl1 35
  • 47.6 (n)
  • 44.21 (a)
Species with no ortholog for ABCB10:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)

Evolution for ABCB10 Gene

ENSEMBL:
Gene Tree for ABCB10 (if available)
TreeFam:
Gene Tree for ABCB10 (if available)

Paralogs for ABCB10 Gene

Paralogs for ABCB10 Gene

(8) SIMAP similar genes for ABCB10 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ABCB10: view

Variants for ABCB10 Gene

Sequence variations from dbSNP and Humsavar for ABCB10 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs4148756 - 229,558,205(-) GCCCC(G/T)CAGCG upstream-variant-2KB, reference, missense
rs35698797 - 229,530,211(+) AGGGT(C/T)GTACA reference, missense
VAR_035735 A breast cancer sample
rs17584642 - 229,547,696(+) AATGC(A/C/G)CTGAC intron-variant, reference, missense
rs12733 -- 229,516,816(-) TAAAC(A/G)GTACA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ABCB10 Gene

Variant ID Type Subtype PubMed ID
nsv827130 CNV Gain 20364138
esv28834 CNV Loss 19812545

Variation tolerance for ABCB10 Gene

Residual Variation Intolerance Score: 31.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.54; 55.71% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ABCB10 Gene

HapMap Linkage Disequilibrium report
ABCB10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ABCB10 Gene

Disorders for ABCB10 Gene

Relevant External Links for ABCB10

Genetic Association Database (GAD)
ABCB10
Human Genome Epidemiology (HuGE) Navigator
ABCB10
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ABCB10

No disorders were found for ABCB10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ABCB10 Gene

Publications for ABCB10 Gene

  1. Characterization and mapping of three new mammalian ATP-binding transporter genes from an EST database. (PMID: 7766993) Allikmets R. … Dean M. (Mamm. Genome 1995) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Genome-wide and gene-centric analyses of circulating myeloperoxidase levels in the charge and care consortia. (PMID: 23620142) Reiner A.P. … Allayee H. (Hum. Mol. Genet. 2013) 3
  4. Structures of ABCB10, a human ATP-binding cassette transporter in apo- and nucleotide-bound states. (PMID: 23716676) Shintre C.A. … Carpenter E.P. (Proc. Natl. Acad. Sci. U.S.A. 2013) 3
  5. ATP-binding cassette B10 regulates early steps of heme synthesis. (PMID: 23720443) Bayeva M. … Ardehali H. (Circ. Res. 2013) 3

Products for ABCB10 Gene

Sources for ABCB10 Gene

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