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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ABCB1 Gene

protein-coding GIFtS: 70
GCID: GC07M087132

ATP-binding cassette, sub-family B (MDR/TAP), member 1

(Previous name: colchicin sensitivity )
(Previous symbols: PGY1, MDR1, CLCS)

Explore 258 diseases affiliated with
ABCB1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 4

Aliases
ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1¹ ²		EC 3.6.3.44³ ⁸
MDR1¹ ² ³ ⁵		P-Gp¹
PGY1¹ ² ³ ⁵		P-GP²
ABC20¹ ²		Doxorubicin Resistance²
CD243¹ ²		Multidrug Resistance Protein 1²
CLCS¹ ²		ATP-Binding Cassette Sub-Family B Member 1³
GP170¹ ²		CD243 Antigen³
Colchicin Sensitivity¹ ²		IBD13⁵
P-Glycoprotein 1² ³		EC 3.6.3⁸

External Ids:	HGNC: 40¹	Entrez Gene: 5243²	Ensembl: ENSG00000085563⁷	OMIM: 171050⁵	UniProtKB: P08183³

ORGUL members:	fRNAdb¹⁰:FR338538 FR115829 FR202795 FR056716
	H-InvDB:HIT000254568 HIT000078111 HIT000254567 HIT000078110 HIT000078109
	NCBI:AY425006 AF345625 AY425005 AF345624 AF345623
	NONCODE:n333130 n333129 n335172 n335175
	RNAdb:HIV1589 HIV1570 HIV1588 HIV1557 HIV1556

Export aliases for ABCB1 gene to outside databases

Previous GC identifers: GC07M085668 GC07M086731 GC07M086745 GC07M086744 GC07M086777 GC07M086970 GC07M081743

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ABCB1:

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC)

transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are

divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the

MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this

gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible

for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to

anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. (provided by RefSeq, Jul

2008)

UniProtKB/Swiss-Prot: MDR1_HUMAN, P08183

Function: Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells

summary for ABCB1:

P-glycoprotein (ABCB1, MDR1) is a well-characterized human ABC transporter that was the first ABC

transporter implicated in multidrug resistance. Normal physiological expression of P-glycoprotein has been

found to prevent uptake of some lipophilic drugs into the brain and other key organs. P-glycoprotein is

frequently overexpressed in cancer cells resulting in drugs being pumped out of the cells faster than they

can enter. This causes a lower concentration of the drug in the cell and reduces the effectiveness of the

drugs in killing cancer cells. Drugs that are affected by classical multidrug resistance include the vinca

alkaloids (vinblastine and vincristine), the anthracyclines (doxorubicin and daunorubicin), the RNA

transcription inhibitor actinomycin D and the microtubule-stabilizing drug taxol.

Gene Wiki entry for ABCB1 (P-glycoprotein)

PharmGKB "VIP" summary for ABCB1

fRNAdb sequence ontology for ABCB1:
ncRNA - An RNA transcript that does not encode for a protein rather the RNA molecule is the gene product.

View fRNAdb secondary structures for ABCB1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000007.13 NC_018918.1 NT_007933.15 NT_079595.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ABCB1 gene promoter:
AML1a AP-1 ATF-2 c-Jun
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): ABCB1 promoter sequence

Search SABiosciences Chromatin IP Primers for ABCB1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ABCB1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q21.12 Ensembl cytogenetic band: 7q21.12 HGNC cytogenetic band: 7q21.12

ABCB1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ABCB1 gene location

GeneLoc information about chromosome 7 GeneLoc Exon Structure

GeneLoc location for GC07M087132: view genomic region (about GC identifiers)

Start:	87,132,948 bp from pter	End:	87,342,611 bp from pter
Size:	209,664 bases	Orientation:	minus strand

1 alternative location:

Chr7-,CRA_TCAG 86,464,460-86,673,878

ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for ABCB1

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MDR1_HUMAN, P08183 (See protein sequence)

Recommended Name: Multidrug resistance protein 1

Size: 1280 amino acids; 141479 Da

Subunit: Interacts with PSMB5

Subcellular location: Cell membrane; Multi-pass membrane protein (By similarity)

Sequence caution: Sequence=AAM49149.1; Type=Erroneous gene model prediction;

Secondary accessions: A8K294 Q12755 Q14812

Explore the universe of human proteins at neXtProt for ABCB1: NX_P08183

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P08183

4/50 DME Specific Peptides for ABCB1 (P08183) (see all 50)

GWKLTLV

RTVVSLT

KILLLDE

ENIRYGR

ABCB1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_000918.2

ENSEMBL proteins:

ENSP00000265724 ENSP00000411075 ENSP00000399419 ENSP00000444095

Reactome Protein details: P08183
Human Recombinant Protein Products for ABCB1:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells Browse OriGene Protein Over-expression Lysates OriGene Custom Protein Services for ABCB1
	GenScript Custom Purified and Recombinant Proteins Services for ABCB1
	Novus Biologicals ABCB1 Protein
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Browse Proteins at Uscn

Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000139	Golgi membrane	IBA	--
GO:0005624	membrane fraction	--	--
GO:0005886	plasma membrane	TAS	--
GO:0009986	cell surface	IDA	12493773
GO:0016020	membrane	TAS	3022150

ABCB1 for ontologies About GeneDecksing

ABCB1 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of ABCB1
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for ABCB1
	OriGene Antibodies (see all 19): ABCB1 OriGene Custom Antibody Services for ABCB1
	GenScript Custom Superior Antibodies Services for ABCB1
	Novus Biologicals ABCB1 Antibodies
	Abcam antibodies for ABCB1
	Browse Antibodies at Uscn
	ThermoFisher Antibodies for ABCB1

Assay Products for ABCB1:

	EMD Millipore Kits and Assays for the Analysis of ABCB1
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for ABCB1
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ABCB1 for domains About GeneDecksing

5/6 InterPro domains/families (see all 6):

IPR003439 ABC_transporter-like

IPR001140 ABC_transptr_TM_dom

IPR003593 AAA+_ATPase

IPR017940 ABC_transporter_type1

IPR011527 ABC_transptrTM_dom_typ1

Graphical View of Domain Structure for InterPro Entry P08183

ProtoNet protein and cluster: P08183

UniProtKB/Swiss-Prot: MDR1_HUMAN, P08183

Similarity: Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201)

subfamily

Similarity: Contains 2 ABC transmembrane type-1 domains

Similarity: Contains 2 ABC transporter domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: MDR1_HUMAN, P08183

Function: Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells

Catalytic activity: ATP + H(2)O + xenobiotic(In) = ADP + phosphate + xenobiotic(Out)

Genatlas biochemistry entry for ABCB1:

ATP binding cassette superfamily,subfamily B (MDR/TAP),member 1,putatively activated by random chromosomal

rearrangements,and overexpressed in acute myeloid leukemia and cancer cell lines,by hypomethylation of the promoter

and altered chromatin structure,up-regulated by P/CAF

Enzyme Numbers (IUBMB): EC 3.6.3.44¹ ² EC 3.6.3²

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005215	transporter activity	TAS	3022150
GO:0005515	protein binding	IPI	--
GO:0005524	ATP binding	IEA	--
GO:0008559	xenobiotic-transporting ATPase activity	IEA	--
GO:0042626	ATPase activity, coupled to transmembrane movement of substances	IBA	--

ABCB1 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for ABCB1:

Decreased viability with pacli

13 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Abcb1a):

behavior/neurological	cardiovascular system	cellular	hearing/vestibular/ear	hematopoietic system
homeostasis/metabolism	immune system	liver/biliary system	mortality/aging	nervous system
no phenotypic analysis	other	reproductive system

ABCB1 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Abcb1a^tm1Bor for ABCB1

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for ABCB1

miRNA Products:		miRTarBase miRNAs that target ABCB1: hsa-mir-451 (MIRT005656)

		OriGene 3'-UTR Clone: ABCB1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ABCB1
		1 QIAGEN miScript miRNA Assays for microRNA that regulate ABCB1:
		hsa-miR-146a*
		SwitchGear 3'UTR luciferase reporter plasmid: ABCB1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ABCB1 (see all 7) OriGene shRNA RFP: ABCB1 OriGene siRNA: ABCB1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ABCB1
		Sirion Biotech Custom design and validation of potent shRNA sequences against ABCB1

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for ABCB1
			Sirion Biotech Customized adenovirus for overexpression of ABCB1 Sirion Biotech Customized adenovirus for potent knockdown of ABCB1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ABCB1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ABCB1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: ABCB1 (NM_000927)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ABCB1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ABCB1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for ABCB1
		Search LifeMap BioReagents cell lines for ABCB1
		Sirion Biotech Customized stable knockdown cell line services for ABCB1 Sirion Biotech Customized inducible knockdown cell line services for ABCB1 Sirion Biotech Customized stable overexpressing cell line services for ABCB1 Sirion Biotech Customized inducible overexpressing cell line services for ABCB1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ABCB1

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/29 super-pathways (see all 29) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Irinotecan Pathway, Pharmacokinetics

	Irinotecan Pathway, Pharmacokinetics	1.00			Mycophenolic acid Pathway, Pharmacokinetics	0.50
	Irinotecan Pathway, Pharmacodynamics	0.50			Taxane Pathway, Pharmacokinetics	0.30

Citalopram Pathway, Pharmacokinetics

	Citalopram Pathway, Pharmacokinetics	1.00			Tacrolimus/Cyclosporine Pathway, Pharmacokinetics	0.33
	Proton Pump Inhibitor Pathway, Pharmacokinetics	0.60			Vinka Alkaloid Pathway, Pharmacokinetics	0.15

Gefitinib Pathway, Pharmacokinetics

	Gefitinib Pathway, Pharmacokinetics	1.00			Erlotinib Pathway, Pharmacokinetics	0.42
	Imatinib Pathway, Pharmacokinetics/Pharmacodynamics	0.58

Pravastatin Pathway, Pharmacokinetics

	Pravastatin Pathway, Pharmacokinetics	1.00			Methotrexate Pathway (Brain Cell), Pharmacokinetics	0.33
	Methotrexate Pathway, Pharmacokinetics	0.47

Abacavir transport and metabolism

Abacavir transport and metabolism

1.00

Abacavir transmembrane transport

0.50

Pathway sources
See GeneCards unified pathways
Show all pathways

3 EMD Millipore Pathways for ABCB1

	Selected targets of C/EBPbeta
	Selected targets of ESR1
	Selected targets of p53

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for ABCB1

Hepatic ABC Transporters

1 Cell Signaling Technology (CST) Pathway for ABCB1

Glucose / Energy Metabolism

5/6 BioSystems Pathways for ABCB1 (see all 6)

	Codeine and morphine metabolism
	Drug Induction of Bile Acid Pathway
	Integrated Pancreatic Cancer Pathway
	Integrated Pancreatic Cancer Pathway
	Nuclear receptors in lipid metabolism and toxicity

5 Reactome Pathways for ABCB1

	ABC-family proteins mediated transport
	Transmembrane transport of small molecules
	Metabolism
	Abacavir transmembrane transport
	Abacavir transport and metabolism

5/28 PharmGKB Pathways for ABCB1 (see all 28)

	Acetaminophen Pathway, Pharmacokinetics
	Atorvastatin/Lovastatin/Simvastatin Pathway, Pharmacokinetics
	Citalopram Pathway, Pharmacokinetics
	Clopidogrel Pathway, Pharmacokinetics
	Codeine and Morphine Pathway, Pharmacokinetics

2 Kegg Pathways (Kegg details for ABCB1):

	ABC transporters
	Bile secretion

ABCB1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for ABCB1

STRING Interaction Network Preview (showing 5 interactants - click image to see 21)

5/30 Interacting proteins for ABCB1 (P08183^{1, 2, 3} ENSP00000265724⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 30)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CAV1	Q03135²^,³, ENSP00000339191⁴	MINT-50920 I2D: score=3 STRING: ENSP00000339191
RNF2	Q99496¹^,³, ENSP00000356480⁴	EBI-1057359,EBI-722416 I2D: score=3 STRING: ENSP00000356480
LAPTM4B	Q86VI4¹^,³	EBI-1057359,EBI-3267258 I2D: score=1
HAX1	O00165³, ENSP00000329002⁴	I2D: score=2 STRING: ENSP00000329002
MYC	P01106³, ENSP00000367207⁴	I2D: score=1 STRING: ENSP00000367207

About this table

Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000086	G2/M transition of mitotic cell cycle	IDA	19384922
GO:0006810	transport	TAS	3022150
GO:0006855	drug transmembrane transport	TAS	--
GO:0042493	response to drug	TAS	3022150
GO:0044281	small molecule metabolic process	TAS	--

ABCB1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

ABCB1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Enzo Life Sciences drugs & compounds for ABCB1

Compounds for ABCB1 available from Tocris Bioscience About this table

Compound	Action	CAS #
PSC 833	Inhibitor of P-gp mediated MDR	[121584-18-7]
Reversan	Selective MRP1 and P-gp inhibitor	[313397-13-6]
XR 9051 HCl	Potent modulator of P-gp-mediated MDR	[180422-22-4]
CP 100356 hydrochloride	P-gp inhibitor	[142716-85-6]

10/257 DrugBank Compounds for ABCB1 (see all 257) About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Verapamil	Verapamil [Usan:Ban:Inn] (see all 4)	52-53-9	transporter	substrate inhibitor inducer	19541926 14985103 12636153 12948019 15504753 10583025 12387747 14698039 8960059 11784143 11454724 10820137 19739078 11082465 12699389 15240100 12649369 11716514 10773005 19944135 15359574 20071452 11602674 19530439 19631272 19125880 15180340 9205004 10997946 19493273 11785684 8621716 9395229 9732409 10571255 11405287 10075817 12954186 12134945 17045309 12569305 11031728 7945455 12604704 10894301 19319690 10087141 11042226 15176077 8094615
Cyclosporine	Ciclosporin (see all 3)	59865-13-3	transporter	substrate inhibitor inducer	14985103 9914792 12636153 8842452 10891114 12948019 12235267 12880295 15504753 14604686 12387747 8960059 11784143 10820137 10227700 12699389 9262363 11716514 10198227 11602674 19530439 9333100 12975485 7681059 12604693 15023456 9205004 11785684 12724138 9732409 10604964 11405287 14744620 12134945 11961113 17045309 10087141 19319690 7514263
Vinblastine	--	865-21-4	transporter	substrate inhibitor inducer	14985103 9751076 12636153 19123050 12948019 9655875 12134946 12235267 8100632 14698039 8960059 12699389 10411602 14706813 11716514 15616150 11961114 19530439 14991868 12107852 19631272 11181899 12604693 10746169 10617675 12081145 11785684 8621716 12724138 1359120 11405287 8862725 12134945 12490309 10087141 19806783
Quinidine	--	56-54-2	transporter	substrate inhibitor	19541926 14985103 12636153 12948019 12948010 10820137 9435299 12699389 12649369 9262363 11716514 11504828 19631272 11785684 9927403 1359120 11405287 12954186 12134945 19319690
Digoxin	--	20830-75-5	transporter	substrate inhibitor inducer	12948019 12948010 14698039 10227700 12699389 11890691 14706813 15032316 19631272 11181899 10746169 15180340 11785684 12788075 9927403 1359120 19806783
Paclitaxel	7-epi-Paclitaxel (see all 5)	33069-62-4	transporter	substrate inhibitor	14985103 15231674 19123050 12948019 12608535 19903471 15211078 14499271 11716514 11602674 15180340 19493273 10617675 11504826 19427995 9531522
Daunorubicin	--	20830-81-3	transporter	substrate inhibitor inducer	20335952 10026252 11602674 10050713 10342576 10746169 10354400 15067695 10617675 11785684 11405287 12134945 10346910 9624121 19806783
Doxorubicin	Doxorubicin HCl (see all 5)	23214-92-8	transporter	substrate inhibitor inducer	9914792 19123050 12948019 1356264 12608535 15211078 19739078 9210482 14499271 19631272 10746169 20179710 19255759 11405287
Imatinib	Imatinib Mesylate (see all 3)	152459-95-5	transporter	substrate inhibitor	15970668 16157201 18669873 20423956 19710702 15805252 19785662 12975485 15315971 16890580 15918555
Vincristine	22-Oxovincaleukoblastine (see all 12)	57-22-7	transporter	substrate inhibitor inducer	14985103 15231674 19123050 12608535 11602674 19493273 10617675 19427995 12134945 12490309 9862789

10/131 Novoseek chemical compound relationships for ABCB1 gene (see all 131) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
rhodamine 123	94.9	877	7669666 (6), 15067695 (6), 11042226 (5), 16647797 (5) (see all 99)
verapamil	91.7	832	7749215 (7), 7906257 (6), 7838133 (6), 10870315 (5) (see all 99)
daunorubicin	91.4	518	10025900 (6), 10444168 (5), 8593279 (4), 7914424 (4) (see all 99)
psc-833	91.1	166	19763573 (6), 9827923 (3), 8639853 (3), 12949955 (3) (see all 86)
doxorubicin	90.8	858	8911123 (6), 19035180 (5), 12940627 (4), 11042226 (4) (see all 99)
vinblastine	89.4	364	8094005 (4), 17982279 (4), 11303953 (4), 17072095 (4) (see all 99)
gf 120918	88.6	129	10098736 (4), 17936633 (3), 14569063 (3), 9864431 (2) (see all 72)
tariquidar	87.5	120	19910428 (5), 10510451 (5), 15457126 (4), 11212278 (4) (see all 45)
vincristine	87.5	372	9719458 (5), 8551799 (5), 15087026 (4), 15371983 (4) (see all 99)
(125i)iodoarylazidoprazosin	84.6	60	16729976 (5), 16505485 (3), 9380680 (3), 10350482 (2) (see all 25)

10/40 PharmGKB related drug/compound annotations for ABCB1 gene (see all 40) About this table

Drug/compound	PharmGKB Annotation
Other antidepressants	CA
Platinum compounds	CA
anthracyclines and related substances	CA
antidepressants	CA
antiepileptics	CA
bisantrene	CA
calcein	CA
capecitabine	CA
carbamazepine	CA
cisplatin	CA

Search CenterWatch for drugs/clinical trials and news about ABCB1 / MDR1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

4 fRNAdb Secondary structures:

REFSEQ mRNAs for ABCB1 gene:

NM_000927.4

Unigene Clusters for ABCB1:

ATP-binding cassette, sub-family B (MDR/TAP), member 1

Hs.489033 [show with all ESTs], Hs.737655 [show with all ESTs]

Unigene Representative Sequences: BC130424, DA234625

11 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000265724(uc011khc.2 uc003uiz.2) ENST00000488737 ENST00000491360

ENST00000415096 ENST00000475929 ENST00000496821 ENST00000483831 ENST00000482527

ENST00000416177(uc003uja.2 uc010lei.2) ENST00000476862 ENST00000543898

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Additional cDNA sequence:

AF345623.1 AF345624.1 AF345625.1 AY425006.1 AY425007.1 AY452673.1

5 DOTS entries:

DT.112315 DT.102836253 DT.121113039 DT.121113006 DT.92419387

24/71 AceView cDNA sequences (see all 71):

AI476464 AW119201 AY425005 AA455911 AA887211 AY425006 BM052878 BX509020

BI964198 CD672146 BI964218 NM_000927 BX645450 AA459824 CR595422 CB164676

AA456377 AA135958 BI964115 BP348942 AI916259 BX474069 BG105127 AA776371

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ABCB1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAGAAATCTA

About this image

ABCB1 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

3 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Brain

Blood Brain Barrier

Endothelial Cells

Selective marker (cell-identifying gene)

Blood Brain Barrier, Endothelium

Brain

Choroid Plexus

Mature Choroid Plexus Cells

Choroid Plexus

Neural Tube

Perineural capillary Plexus

Angioblasts

Blood Brain Barrier, Endothelium

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 7 LifeMap Cells

Name

Category

Cardiosphere-derived cells (Primary Cell)

Heart, Myocardium

PureStem™ epithelial progenitor E164 (Embryonic Progenitor Cell)

Intermediate Mesoderm, Kidney

PureStem™ progenitor W8 (Embryonic Progenitor Cell)

Mature brain microvascular endothelial cells (Derivation of blood-...)

Brain microvascular endothelial cells (Derivation of blood-...)

Endothelial cells (Derivation of blood-...)

Endothelial cells and neural cells (Derivation of blood-...)

See ABCB1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ABCB1

SOURCE GeneReport for Unigene clusters: Hs.489033 Hs.737655

UniProtKB/Swiss-Prot: MDR1_HUMAN, P08183

Tissue specificity: Expressed in liver, kidney, small intestine and brain

SABiosciences Expression via Pathway-Focused PCR Arrays including ABCB1 (see all 11):

Nephrotoxicity in human mouse rat

Prostate Cancer in human mouse rat

Hepatotoxicity in human mouse rat

Drug Metabolism in human mouse rat

WNT Signaling Targets in human mouse rat

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for ABCB1 gene from 8/33 species (see all 33) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	ABCB1¹	ATP-binding cassette, sub-family B (MDR/TAP), member 1 less	71.75(n) 73.03(a)		395712 NM_204894.1 NP_990225.1
lizard (Anolis carolinensis)	Reptilia	-- ABCB11⁶	--	70(a) 51(a)	1 ↔ many possible ortholog	6(19286963-19334220) 1(245243036-245267304)
tropical clawed frog (Xenopus tropicalis)	Amphibia	MGC76216²	hypothetical protein MGC76216	72.53(n)		BC063924.1
zebrafish (Danio rerio)	Actinopterygii	57070059²	--	73.44(n)		57070059
fruit fly (Drosophila melanogaster)	Insecta	CG10226³ Mdr50¹	multidrug transporter³ Multi drug resistance 50¹	65(a) (best of 4)³ 50.94(n)¹ 44.72(a)¹		65A10³ 36582¹ NM_079016.3¹ NP_523740.3¹
worm (Caenorhabditis elegans)	Secernentea	pgp-1³ pgp-9¹	multidrug resistance protein³ Protein PGP-9¹	45(a) (best of 11)³ 51.96(n)¹ 46.92(a)¹		IV(12592000-12599340)³ 180165¹ NM_075086.2¹ NP_507487.1¹
thale cress (Arabidopsis thaliana)	eudicotyledons	PGP9⁶ MDR3⁶ (see all 21)	ABC transporter B family member 3 (see all 21)	41(a) 41(a) (see all 21)	many ↔ many many ↔ many (see all 21)	4(10022205-10027415) 4(780734-785329)
rice (Oryza sativa)	Liliopsida	Os.20120²	Oryza sativa (japonica cultivar-group) cDNA clone001-012-H08, full insert sequence less	72.39(n)		NM_183599.1

ENSEMBL Gene Tree for ABCB1 (if available)
TreeFam Gene Tree for ABCB1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ABCB1 gene

ABCB4² ABCB11² ABCB5²

17 SIMAP similar genes for ABCB1 using alignment to 16 protein entries: MDR1_HUMAN (see all proteins):

ABCB4 ABCB5 MDR1 TAP1 ABCB11 NG-TRA

LOC402251 ABCB6 ABCB9 ABCB10 TAP2-G TAP2

CFTR DKFZp434I2115 ABCB8 ABCB7 ABCG2

ABCB1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

UniProtKB/Swiss-Prot: MDR1_HUMAN, P08183

Polymorphism: Genetic variation in ABCB1 may play a role in patients who do not respond to drug treatment

SNP ID	Valid	Clinical significance	Chr 7 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs1128501^1,2	C	pathogenic	86527029(-)	`TGAAGG/TAATTG`	2	G V	mis¹		2		NA	4
rs199473694^1,2	C	other	86674406(-)	`AATTAC/TTTTTT`	1	--	us2k¹		0	--	--	--	--
rs199473696^1,2	C	other	86675197(+)	`AACCTA/GTGATT`	1	--	us2k¹		0	--	--	--	--
rs10677970^1,2	C	--	81865915(+)	`ATATA-/TGTGTCA`	1	--	int¹		0	--	--	--	--
rs28364281^1,2	C	--	86464509(-)	`CCATCT/CGGCTT`	1	--	ds500¹		6		NS NA	174
rs41297348^1,2	C	--	86464678(-)	`CATCTT/CGTCCA`	1	--	ds500¹		3		NA	498
rs57126620^1,2	C	--	86464716(-)	`GTGTCT/CATAAT`	1	--	ut3¹		1		--	494
rs28364280^1,2	C,F,H	--	86464755(-)	`TTATAG/AAAGTA`	1	--	ut3¹ ese³		13		NS NA	1564
rs28364279^1,2	C,F,H	--	86464819(-)	`ATAAAA/CTGTGT`	1	--	ut3¹		13		NS NA WA	1590
rs28364278^1,2	C,F	--	86464898(-)	`AGACA-/GAG AGACATCATC`	1	--	ut3¹		5		NS	184

HapMap Linkage Disequilibrium report for ABCB1 (87132948 - 87342611 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 6 variations for ABCB1
6 CNVs: 64878 82071 94660 94662 62688 94661
Human Gene Mutation Database (HGMD): ABCB1

SABiosciences Cancer Mutation PCR Assays

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Prostate Cancer

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ABCB1 for disorders           About GeneDecksing

OMIM gene information: 171050OMIM information: 141400 605635
OMIM disorders: 612244
UniProtKB/Swiss-Prot: MDR1_HUMAN, P08183

Genetic variations in ABCB1 are associated with susceptibility to inflammatory bowel disease type 13 (IBD13)

[MIM:612244]. Inflammatory bowel disease is characterized by a chronic relapsing intestinal inflammation. It is

subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may involve any part of the

gastrointestinal tract, but most frequently the terminal ileum and colon. Bowel inflammation is transmural and

discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in

ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and

granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints. Crohn

disease and ulcerative colitis are commonly classified as autoimmune diseases

20/258 diseases for ABCB1 (see all 258): About MalaCards

5-fluorouracil toxicity b-cell non-hodgkin lymphoma colchicine resistance attention deficit hyperactivity disorder

non-hodgkin lymphoma soft tissue sarcoma paralytic ileus dna topoisomerase ii

pervasive developmental disorder cerebral amyloid angiopathy fibrous histiocytoma dna topoisomerase i

inflammatory bowel disease 13 graft versus host disease sclerosing cholangitis non-small cell lung carcinoma

inflammatory bowel disease postural hypotension temporal lobe epilepsy malignant fibrous histiocytoma

8 diseases from the University of Copenhagen DISEASES database for ABCB1:

Leukemia Breast cancer Lung cancer Ovarian cancer

Colorectal cancer Carcinoma Lymphoma Hepatocellular carcinoma

10/89 Novoseek disease relationships for ABCB1 gene (see all 89) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
cancer	75.3	928	19369960 (4), 9476146 (4), 17290610 (4), 11245443 (4) (see all 99)
leukemia	75.2	389	9439046 (4), 14642128 (4), 1859877 (3), 9594630 (3) (see all 99)
tumors	72.3	1527	17895794 (6), 9815963 (6), 1359152 (6), 18300948 (5) (see all 99)
breast cancer	70.3	601	8679460 (7), 10092063 (6), 16200770 (4), 8068207 (4) (see all 99)
colchicine resistance	69.4	8	11284688 (1), 1968359 (1), 8599208 (1), 15049699 (1) (see all 5)
aml adult	68	26	19291917 (3), 10419897 (3), 10374270 (2), 17038891 (2) (see all 14)
acute leukemia	67.8	134	8477061 (6), 16086884 (5), 15512810 (4), 17538395 (4) (see all 73)
colon carcinoma	65.2	92	12894558 (3), 8207045 (3), 7476894 (3), 8103760 (3) (see all 53)
ovarian carcinoma	60	67	10767994 (5), 10537344 (4), 7799045 (3), 9639738 (3) (see all 35)
secondary aml	58.2	11	1283551 (1), 8075575 (1), 9129038 (1), 8628017 (1) (see all 11)

Genetic Association Database (GAD): ABCB1
Human Genome Epidemiology (HuGE) Navigator: ABCB1 (740 documents)

Export disorders for ABCB1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ABCB1 gene, integrated from 9 sources (see all 4673):
(articles sorted by number of sources associating them with ABCB1)

Utopia: connect your pdf to the dynamic
world of online information

MDR1 Ala893 polymorphism is associated with inflammatory bowel disease. (PubMed id 14610718)^{1, 2, 4} Brant S.R....Cho J.H. (2003)
Frequency of single nucleotide polymorphisms in the P-glycoprotein drug transporter MDR1 gene in white subjects. (PubMed id 11240981)^{1, 2, 4} Cascorbi I.... Roots I. (2001)
Modulation of multidrug resistance P-glycoprotein 1 (ABCB1) expression in human heart by hereditary polymorphisms. (PubMed id 15247630)^{1, 4, 9} Meissner K....Kroemer H.K. (2004)
CYP2C9, CYP2C19, ABCB1 (MDR1) genetic polymorphisms and phenytoin metabolism in a Black Beninese population. (PubMed id 16220110)^{1, 4, 9} Allabi A.C....Horsmans Y. (2005)
The effect of CYP3A5 and MDR1 polymorphic expression on cyclosporine oral disposition in renal transplant patients. (PubMed id 12817518)^{1, 4, 9} Yates C.R....Meibohm B. (2003)
Pharmacogenetic profiling across the irinotecan pathway in Asian patients with cancer. (PubMed id 15801936)^{1, 4, 9} Zhou Q....Chowbay B. (2005)
Sirolimus and tacrolimus trough concentrations and dose requirements after kidney transplantation in relation to CYP3A5 and MDR1 polymorphisms and steroids. (PubMed id 16249748)^{1, 4, 9} Mourad M....Haufroid V. (2005)
Influence of functional polymorphisms of the MDR1 gene on vincristine pharmacokinetics in childhood acute lymphoblastic leukemia. (PubMed id 15371983)^{1, 4, 9} Plasschaert S.L....de Bont E.S. (2004)
Association of the multidrug resistance-1 gene single-nucleotide polymorphisms with the tacrolimus dose requirements in renal transplant recipients. (PubMed id 12819250)^{1, 4, 9} Anglicheau D....Thervet E. (2003)
Effects of ABCB1 (multidrug resistance transporter) gene mutations on disposition and central nervous effects of loperamide in healthy volunteers. (PubMed id 14583678)^{1, 4, 9} Skarke C....Lotsch J. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 5243	HGNC: 40	AceView: ABCB1	Ensembl:ENSG00000085563	euGenes: HUgn5243
ECgene: ABCB1	Kegg: 5243	H-InvDB: ABCB1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ABCB1	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for ABCB1	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/abcb1/
SHMPD	http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=ABCB1
Wikipedia	http://en.wikipedia.org/wiki/P-glycoprotein
ABCMdb	http://abcmutations.hegelab.org/proteinDetails?uniprot_id=P08183

Intellectual Property for ABCB1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for ABCB1 gene:
Search GeneIP for patents involving ABCB1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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ABCB1 Gene

ATP-binding cassette, sub-family B (MDR/TAP), member 1

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Lymphoblastic Leukemia Acute Childhood
Renal Cancer
Erythroleukemia
Cystic Fibrosis
Colitis Ulcerative
ADENOCARCINOMA LUNG
COLON CARCINOMA
PARATHYROID ADENOMA
LUNG CARCINOMA
Small kidney
Breast Cancer
primary tumor
NSCLC
Ganglioneuroblastoma
Adenocarcinoma
refractory cancer
childhood rhabdomyosarcoma
Cancer
Rhabdomyosarcoma
Colorectal Carcinoma
Sarcoma Epithelioid
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Carcinoma Non-Small Cell Lung
COLCHICINE RESISTANCE
GASTRIC CARCINOMA
COLON ADENOCARCINOMA
Ovarian Cancer
Epilepsy Temporal Lobe
Epilepsy
TUMOR LIVER
Monocytic leukemia
MYELOMA
Tumors
Metastasis
Sarcoma
Lymphoblastic Leukemia Acute
Glioblastoma
breast cancer metastatic
Hepatoblastoma
MPNST
Malignant Glioma
COLON TUMOR
progressive disease
Gastric Cancer
Myeloid Leukemia
Leukemia Nonlymphocytic Acute
Brain Tumors
BREAST CARCINOMA
adult soft tissue sarcoma
bladder cancer
Colon Cancer
promyelocytic leukemia
Leukemia Lymphocytic Chronic
Glioma
Neurothekeoma
uterine sarcoma
Carcinoma
ACUTE LEUKEMIA
Leukemia
Myeloid Leukemia Chronic
organ rejection
Osteosarcoma
Blast Crisis
HEPATOCELLULAR CARCINOMA
CERVICAL CARCINOMA
Carcinoma Renal Cell
AML adult
Cancer Lung
Hematologic Malignancies
small cell lung cancer
metastatic renal cell carcinoma
RHABDOMYOSARCOMA 1
Inflammatory Bowel Diseases
Wilms tumor
T-ALL
OVARIAN CARCINOMA
Lymphocytic Leukemia Chronic B-Cell
solid tumor
Carcinoma Squamous Cell
AML childhood
Leukemia Promyelocytic Acute
secondary AML
neuroblastoma metastatic
plasma cell myeloma
Gastrointestinal carcinoma
residual disease
Lymphoma Non-Hodgkins
Myelodysplastic Syndromes
LEUKAEMIA LYMPHOCYTIC

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Export list of displayed genes

ABCB1 Gene

ATP-binding cassette, sub-family B (MDR/TAP), member 1

Aliasesfor ABCB1 gene

Summariesfor ABCB1 gene

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Proteinsfor ABCB1 gene

Protein Domains /Familiesfor ABCB1 gene

Functionfor ABCB1 gene

Pathways & Interactionsfor ABCB1 gene

Drugs & Compoundsfor ABCB1 gene

Transcriptsfor ABCB1 gene

Expression for ABCB1 gene

Orthologsfor ABCB1 gene

Paralogsfor ABCB1 gene

Genomic Variantsfor ABCB1 gene

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Aliases
for ABCB1 gene

Summaries
for ABCB1 gene

Genomic Views
for ABCB1 gene

Proteins
for ABCB1 gene

Protein Domains /
Families
for ABCB1 gene

Function
for ABCB1 gene

Pathways & Interactions
for ABCB1 gene

Drugs & Compounds
for ABCB1 gene

Transcripts
for ABCB1 gene

Expression
for ABCB1 gene

Orthologs
for ABCB1 gene

Paralogs
for ABCB1 gene

Genomic Variants
for ABCB1 gene

Disorders / Diseases
for ABCB1 gene

Publications
for ABCB1 gene

Intellectual Property
for ABCB1 gene

Products
for ABCB1 gene