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ABCB1 Gene

protein-coding GIFtS: 68

GC07M086970

ATP-binding cassette, sub-family B (MDR/TAP), member 1
(Previous name: colchicin sensitivity )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: PGY1, MDR1, CLCS)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
ABC20 ^¹, ²
CD243 ^¹, ²
CLCS ^²
EC 3.6.3.44 ^³
GP170 ^¹, ²
IBD13 ^⁵
MDR1 ^², ³, ⁵
MGC163296 ^²
P-GP ^²
P-gp ^¹
PGY1 ^², ³, ⁵

Descriptions
ATP-binding cassette sub-family B member 1 ^³
ATP-binding cassette, sub-family B (MDR/TAP), member 1 ^²
ATP-binding cassette, subfamily B, member 1 ^²
CD243 antigen ^³
P-glycoprotein 1 ^², ³
colchicin sensitivity ^¹, ²
doxorubicin resistance ^²
multidrug resistance protein 1 ^²

External Ids
HGNC: 40¹
Entrez Gene: 5243²
UniProtKB: P08183³
Ensembl: ENSG00000085563⁷

Search outside databases for aliases for ABCB1 gene

Previous GC identifers: GC07M085668 GC07M086731 GC07M086745 GC07M086744 GC07M086777

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for ABCB1:

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding

cassette (ABC) transporters. ABC proteins transport various molecules across extra- and

intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP,

MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the

MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an

ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is

responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the

development of resistance to anticancer drugs. This protein also functions as a transporter in the

blood-brain barrier. [provided by RefSeq]

UniProtKB/Swiss-Prot: MDR1_HUMAN, P08183

Function: Energy-dependent efflux pump responsible for decreased drug accumulation in

multidrug-resistant cells

Gene Wiki entry for ABCB1 (P-glycoprotein)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ABCB1 gene

Entrez Gene cytogenetic band: 7q21.1 Ensembl cytogenetic band: 7q21.12 HGNC cytogenetic band: 7q21.12

ABCB1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 7 GeneLoc Exon Structure

GeneLoc location for GC07M086970: (about GC identifiers)

Start:	86,970,884 bp from pter
End:	87,180,506 bp from pter
Size:	209,623 bases
Orientation:	minus strand

1 alternative location:

Chr7-,CRA_TCAG 86,464,460-86,673,878

RefSeq DNA sequence:

NC_000007.12 NT_007933.14 NT_079595.2

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: MDR1_HUMAN, P08183 (See protein sequence)

Recommended Name: Multidrug resistance protein 1

Size: 1280 amino acids; 141479 Da

Subcellular location: Membrane; Multi-pass membrane protein

Sequence caution: Sequence=AAB69423.1; Type=Erroneous gene model prediction;

Secondary accessions: Q12755 Q14812

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_000918.2

ENSEMBL proteins:

ENSP00000378156 ENSP00000265724

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Sigma-Aldrich Proteins for ABCB1
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (P Glycoprotein)
	Human Recombinant Proteins from Abnova (ABCB1)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

4 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005624	membrane fraction	TAS	3022150
GO:0009986	cell surface	IDA	12493773
GO:0016020	membrane	IEA	--
GO:0016021	integral to membrane	TAS	3768958

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Antibodies for ABCB1:

	Invitrogen Antibodies for ABCB1
	Millipore Mono- and Polyclonal Antibodies for the study of ABCB1
	Sigma-Aldrich Antibodies for ABCB1
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (P Glycoprotein), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (ABCB1)
	Novus Biologicals Antibodies for ABCB1

Assays for ABCB1:

	Browse Invitrogen for biochemical assays
	Millipore Kits and Assays for the Analysis of ABCB1
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ProtoNet protein and cluster: P08183

UniProtKB/Swiss-Prot: MDR1_HUMAN, P08183

Similarity: Belongs to the ABC transporter family. Multidrug resistance exporter (TC 3.A.1.201)

subfamily

Similarity: Contains 2 ABC transmembrane type-1 domains

Similarity: Contains 2 ABC transporter domains

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ABCB1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ABCB1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000927

Applied Biosystems Silencer® siRNAs for ABCB1

Sigma-Aldrich siRNA and siRNA Panels for ABCB1

Sigma-Aldrich shRNA for ABCB1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_000927
Myc/DDK tagged cDNA clone in CMV expression vector: NM_000927
untagged cDNA clone in CMV expression vector: NM_000927

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_000927

UniProtKB/Swiss-Prot: MDR1_HUMAN, P08183

Function: Energy-dependent efflux pump responsible for decreased drug accumulation in

multidrug-resistant cells

Catalytic activity: ATP + H(2)O + xenobiotic(In) = ADP + phosphate + xenobiotic(Out)

Enzyme Number (IUBMB): EC 3.6.3.44

Genatlas biochemistry entry for ABCB1:

ATP binding cassette superfamily,subfamily B (MDR/TAP),member 1,putatively activated by random

chromosomal rearrangements,and overexpressed in acute myeloid leukemia and cancer cell lines,by

hypomethylation of the promoter and altered chromatin structure,up-regulated by P/CAF

9 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Abcb1a):

	behavior/neurological	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism
immune system	nervous system	no phenotypic analysis	reproductive system

5/7 Gene Ontology (GO) molecular function terms (links to tree view) (see all 7 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0005215	transporter activity	TAS	3022150
GO:0005515	protein binding	IPI	17088979
GO:0005524	ATP binding	TAS	3768958
GO:0008559	xenobiotic-transporting ATPase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5 Sigma-Aldrich "Your Favorite Gene" Pathways for ABCB1 (Your Favorite Gene powered by Ingenuity)

IL-6 Signaling
Hepatic Cholestasis
LPS/IL-1 Mediated Inhibition of RXR Function
Xenobiotic Metabolism Signaling
PXR/RXR Activation

GeneDecks ABCB1 for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for ABCB1

5/100 Interacting proteins for ABCB1 (ENSP00000265724³ P08183^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 100 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CAV1	Q03135²	STRING (score=.977) MINT-50920
RNF2	Q99496¹	EBI-1057359, EBI-722416
TP53	ENSP00000269305³	STRING (score=.996)
NR1I2	ENSP00000336528³	STRING (score=.983)
CYP3A5	ENSP00000222982³	STRING (score=.968)

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2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006810	transport	TAS	3022150
GO:0042493	response to drug	TAS	3022150

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
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Browse drugs & compounds from Enzo Life Sciences

Sigma-Aldrich Small Molecules for ABCB1:

Mixed Agonist/Antagonist Antagonist Agonist

Compounds for ABCB1 available from Tocris Bioscience

Compound	Action	CAS number
XR 9051 HCl	Potent modulator of P-gp-mediated MDR	[180422-22-4]

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10/30 Novoseek chemical compound relationships for ABCB1 gene (see all 30 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
rhodamine 123	94.81	806	7669666 (6), 15067695 (6), 11042226 (5), 16647797 (5) (see all 99)
gf 120918	87.87	117	10098736 (4), 17936633 (3), 14569063 (3), 9864431 (2) (see all 62)
tariquidar	86.56	89	10510451 (5), 15457126 (4), 11212278 (4), 16650133 (3) (see all 35)
(125i)iodoarylazidoprazosin	85.19	60	16729976 (5), 16505485 (3), 9380680 (3), 10350482 (2) (see all 25)
ly335979	84.69	28	12455064 (4), 10411602 (4), 11331075 (3), 11724763 (1) (see all 13)
azidopine	81.31	26	7841043 (2), 7903910 (1), 7982498 (1), 7887974 (1) (see all 18)
biricodar	78.11	9	11408511 (2), 11895894 (1), 12721757 (1), 9738565 (1) (see all 5)
(glc)4	76.83	10	9414384 (1), 10188979 (1), 11585053 (1), 8980384 (1) (see all 8)
tetramethylrosamine	76.00	10	16800628 (2), 11248688 (2), 11552983 (1), 15358289 (1)
colchicine	73.18	133	9619779 (5), 12235361 (5), 11284688 (4), 16978677 (4) (see all 59)

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10/31 PharmGKB drug compound relationships for ABCB1 gene (see all 31 )

Drug compound	PharmGKB Relations	PubMed IDs for articles supporting these relationships
5-fluorouracil	CO GN	14740638
6-mercaptopurine	FA	10840050
6-thioguanine	FA	10840050
arsenic trioxide	FA	14642128
arsenite	PD GN	20404014
asparaginase	CO	15713801
calcein	FA GN	12893986
colchicine	FA	2568832
cytarabine	CO	15713801
daunorubicin	CO	15713801

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(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ABCB1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ABCB1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000927

Sigma-Aldrich siRNA and siRNA Panels for ABCB1

Sigma-Aldrich shRNA for ABCB1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000927

REFSEQ mRNAs for ABCB1 gene:

NM_000927.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000927

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_000927
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_000927
                                 untagged cDNA clone in CMV expression vector: NM_000927

Additional cDNA sequence:

AB208970.1 AF016535.1 AF345623.1 AF345624.1 AF345625.1 AK290159.1 AK308467.1 AY425005.1

AY425006.1 AY425007.1 AY452673.1 BC130424.1 CR595422.1 EU852583.1 EU854148.1 M14758.1

5 DOTS entries:

DT.112315 DT.102836253 DT.121113039 DT.121113006 DT.92419387

24/71 AceView cDNA sequences (see all 71 ):

AI476464 AW119201 BI964218 AA456377 BX645450 NM_000927 CB164676 BM052878

AA455911 AA459824 CD672146 AY425005 AA887211 CR595422 BX509020 AY425006

BI964198 BP348942 BI964115 BG105127 AA776371 AJ709195 BM053038 BV205545

highest scoring ESTs for ABCB1:

M14758 AF345623 AF345624 AY452673 AA135957 AA135958 AA455911 AA456377 AA459824 AA776371

Unigene Cluster for ABCB1:

ATP-binding cassette, sub-family B (MDR/TAP), member 1

Hs.489033 [show with all ESTs]

Unigene Representative Sequence: NM_000927

GeneLoc Exon Structure

2 Ensembl transcripts including schematic representations:

ENST00000394661 ENST00000265724

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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ABCB1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ABCB1

¹ / ² / ³

7 probe-sets matching ABCB1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
1682_s_at²^{, 3}	U95-A	1	1.00	1.00	0.46	0.70	X58723	0.20	1.00	0.72	1
1575_at²^{, 3}	U95-A	1	1.00	1.00	0.89	1.31	M14758	1.00	0.90	0.95	1
1576_g_at²^{, 3}	U95-A	2	1.00	0.50	0.87	1.06	M14758	1.00	0.90	0.95	1
209993_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AF016535	0.40	1.00	0.76	1
209994_s_at²^{, 3}	U133-A	2	1.00	0.50	--	--	AF016535	0.40	1.00	0.76	1
209993_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
209994_s_at²	U133Plus2	2	1.00	0.50	--	--	--	--	--	--	--

GeneDecks ABCB1 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.489033
Expression variation in blood from EXPOLDB for ABCB1
UniProtKB/Swiss-Prot: MDR1_HUMAN, P08183
Tissue specificity: Expressed in liver, kidney, small intestine and brain

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for ABCB1 gene from 5/18 species (see all 18 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ABCB1¹	--	ATP-binding cassette, sub-family B (MDR/TAP), member more	90.06(n) 90.61(a)	403879 NM_001003215.1 NP_001003215.1
chimpanzee (Pan troglodytes)	ABCB1¹	--	ATP-binding cassette, sub-family B (MDR/TAP), member more	99.56(n) 99.53(a)	463516 XM_001163342.1 XP_001163342.1
cow (Bos taurus)	ABCB1¹	--	ATP-binding cassette, sub-family B (MDR/TAP), member more	87.58(n) 88.9(a)	281585 XM_590317.3 XP_590317.3
rat (Rattus norvegicus)	Abcb1¹	--	ATP-binding cassette, sub-family B (MDR/TAP), member more	85.73(n) 87.57(a)	170913 NM_133401.1 NP_596892.1
mouse (Mus musculus)	Abcb1a^{1, 5}	5 (1.00 cM)⁵	ATP-binding cassette, sub-family B (MDR/TAP), member more^{1, 5}	85.99(n)¹ 87.45(a)¹	18671¹ NM_011076.1¹ NP_035206.1¹ AK008292⁵ AK144907⁵ (see all 12)

About this table Species with no ortholog for ABCB1

ENSEMBL Gene Tree for ABCB1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for ABCB1 gene

SNRNP35² ABCB4² ABCB11²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

UniProtKB/Swiss-Prot: MDR1_HUMAN, P08183

Polymorphism: Genetic variation in ABCB1 may play a role in patients who do not respond to drug

treatment

10/956 NCBI SNPs in ABCB1 are shown (see all 956 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 525)

AB	SNP ID	Valid	Chr 7 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs1055302^1,2	A,C,F,H	86970852(-)	`AGATCG/AATATA`	1	--	ng5¹		18	MN NS EU EA WA NA	1552
	rs2032582^1,2	A,C,F,H	86998554(-)	`AAGGTA/G/TCTGGG`	2	S/T S/A	mis¹		23	MN CSAM EA EU WA NA NS	2642
	rs2214102^1,2	A,C,F,H	87067437(-)	`GTCGGG/AATGGA`	1	--	ut5¹		23	MN CSAM EA NA NS EU WA	2080
	rs9282564^1,2	C,F,H	87067376(-)	`TGAACA/GATAAA`	1	N/D	mis¹ ese³		26	MN CSAM EA NS EU WA NA	2546
	rs1202183^1,2	C,F,H	87052919(-)	`TTCAAA/GTTGGC`	1	N/S	mis¹		16	NA EA MN EU WA CSAM	1130
	rs2229109^1,2	C,F,H	87017745(-)	`CTTCAG/ATTACC`	1	N/S	mis¹		28	MN NA EU EA WA NS CSAM	2568
	rs2229107^1,2	C,F,H	86976595(-)	`TGGTGT/ACACAG`	1	T/S	mis¹ ese³		19	MN NA EU EA WA NS CSAM	1686
	rs3213619^1,2	C,F,H	87068129(-)	`TCGAGT/CAGCGG`	1	--	ut5¹ ese³		14	NA NS EU EA WA	1262
	rs17064^1,2	C,F,H	86971406(-)	`GAATTA/TTGAAG`	1	--	ut3¹ ese³		11	MN EU EA WA NS	842
	rs2032581^1,2	F,H	86998746(-)	`AGGCTA/GTAGGT`	1	I/V	mis¹ ese³		5	EU EA WA	524

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HapMap Linkage Disequilibrium images for ABCB1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 171050

UniProtKB/Swiss-Prot: MDR1_HUMAN, P08183

Genetic variations in ABCB1 are associated with susceptibility to inflammatory bowel

disease type 13 (IBD13) [MIM:612244]. Inflammatory bowel disease is characterized by a chronic

relapsing intestinal inflammation. It is subdivided into Crohn disease and ulcerative colitis

phenotypes. Crohn disease may involve any part of the gastrointestinal tract, but most frequently

the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain

granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative

colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas

and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin,

eyes, or joints. Crohn disease and ulcerative colitis are commonly classified as autoimmune

diseases

10/90 Novoseek disease relationships for ABCB1 gene (see all 90 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
cancer	74.85	826	9476146 (4), 17290610 (4), 17342344 (4), 11245443 (4) (see all 99)
leukemia	74.65	369	9439046 (4), 14642128 (4), 1859877 (3), 9594630 (3) (see all 99)
tumors	72.50	1447	17895794 (6), 9815963 (6), 1359152 (6), 18300948 (5) (see all 99)
colchicine resistance	70.10	8	11284688 (1), 1968359 (1), 8599208 (1), 15049699 (1) (see all 5)
breast cancer	68.69	508	8679460 (7), 10092063 (6), 16200770 (4), 15034303 (4) (see all 99)
acute leukemia	67.88	132	8477061 (6), 16086884 (5), 15512810 (4), 17538395 (4) (see all 71)
aml adult	67.07	26	19291917 (3), 10419897 (3), 10374270 (2), 17038891 (2) (see all 14)
colon carcinoma	66.04	89	12894558 (3), 8207045 (3), 7476894 (3), 8103760 (3) (see all 51)
ovarian carcinoma	60.23	66	10767994 (5), 10537344 (4), 7799045 (3), 9639738 (3) (see all 34)
secondary aml	59.78	11	1283551 (1), 8075575 (1), 9129038 (1), 8628017 (1) (see all 11)

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10/11 PharmGKB disease relationships for ABCB1 gene (see all 11 )

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Blood Coagulation Disorders	CO GN	14676821
Depression	PD	10700657
Epilepsy	CO GN	12686700
HIV	PK	11809184
Leukemia	FA	14642128
Leukemia, Lymphocytic, Acute, L1	CO PD FA	10840050 15630450 15713801
Neoplasms	CO PK GN	14740638 12960109
Organ Transplantation	PK GN	12490779
Parkinson Disease	PD GN	12724617
liver transplantation	FA	12172213

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Human Gene Mutation Database: ABCB1
Genetic Association Database: ABCB1
Human Genome Epidemiology Navigator: ABCB1 (490 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/3035 PubMed articles for ABCB1 gene (see all 3035 ):

Warfarin sensitivity related to CYP2C9, CYP3A5, ABCB1 (MDR1) and other factors. (PubMed id 14676821)^{1, 3, 6, 7} Wadelius M....Melhus H. (2004)
Irinotecan pathway genotype analysis to predict pharmacokinetics. (PubMed id 12960109)^{1, 3, 6, 7} Mathijssen R.H....McLeod H.L. (2003)
Response to antiretroviral treatment in HIV-1-infected individuals with allelic variants of the multidrug resistance transporter 1: a pharmacogenetics study. (PubMed id 11809184)^{1, 3, 6, 7} Fellay J....Telenti A. (2002)
Genetic polymorphism in MDR-1: a tool for examining allelic expression in normal cells, unselected and drug-selected cell lines, and human tumors. (PubMed id 9473242)^{1, 3, 4, 7} Mickley L.A.... Fojo T. (1998)
Haplotype analysis of ABCB1/MDR1 blocks in a Japanese population reveals genotype-dependent renal clearance of irinotecan. (PubMed id 14646693)^{3, 6, 7} Sai K....Sawada J. (2003)
MDR1 Ala893 polymorphism is associated with inflammatory bowel disease. (PubMed id 14610718)^{3, 4, 6} Brant S.R....Cho J.H. (2003)
Polymorphism in the P-glycoprotein drug transporter MDR1 gene: a possible link between environmental and genetic factors in Parkinson's disease. (PubMed id 12724617)^{3, 6, 7} Drozdzik M....Sych Z. (2003)
Association of multidrug resistance in epilepsy with a polymorphism in the drug-transporter gene ABCB1. (PubMed id 12686700)^{3, 6, 7} Siddiqui A....Sisodiya S.M. (2003)
Role of human MDR1 gene polymorphism in bioavailability and interaction of digoxin, a substrate of P-glycoprotein. (PubMed id 12189368)^{3, 6, 7} Kurata Y....Otsubo K. (2002)
C3435T polymorphism in the MDR1 gene affects the enterocyte expression level of CYP3A4 rather than Pgp in recipients of living-donor liver transplantation. (PubMed id 12172213)^{1, 3, 7} Goto M....Inui K. (2002)

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		AND	OR
Aliases
Free Text

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 5243	HGNC: 40	AceView: ABCB1	Ensembl:ENSG00000085563	euGenes: HUgn5243
ECgene: ABCB1	H-InvDB: ABCB1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for ABCB1	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/abcb1/
SHMPD	http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=ABCB1
Wikipedia	http://en.wikipedia.org/wiki/P-glycoprotein

Licensable Technologies for ABCB1
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for ABCB1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ABCB1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ABCB1		Antibodies for ABCB1
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	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (ABCB1)
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	Antibodies (P Glycoprotein)

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Tocris compounds for ABCB1

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for ABCB1

GeneCards Homepage - Last full update: 1 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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ABCB1 Gene at Home site.
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ABCB1 Gene

protein-coding GIFtS: 68

Aliases &
Descriptions
for ABCB1

Summaries
for ABCB1

Genomic Location
for ABCB1

Proteins
for ABCB1

Protein Domains/
Families
for ABCB1

Gene Function
for ABCB1

Pathways & Interactions
for ABCB1

Drugs & Compounds
for ABCB1

Transcripts
for ABCB1

Expression
for ABCB1

Orthologs
for ABCB1

Paralogs
for ABCB1

SNPs/Variants
for ABCB1

Disorders & Mutations
for ABCB1

Medical News
for ABCB1

Publications
for ABCB1

Search for ABCB1

Genome Databases showing ABCB1

Other Databases showing ABCB1

Specialized Databases showing ABCB1

Licensable Technologies
for ABCB1

Services
for ABCB1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ABCB1 (Gene Symbol)
ABC20
CD243
CLCS
EC 3.6.3.44
GP170
IBD13
MDR1
MGC163296
P-GP
P-gp
PGY1
ATP-binding cassette sub-family B member 1
ATP-binding cassette, sub-family B (MDR/TAP), member 1
ATP-binding cassette, subfamily B, member 1
CD243 antigen
P-glycoprotein 1
colchicin sensitivity
doxorubicin resistance
multidrug resistance protein 1

ABCB1 Gene

protein-coding GIFtS: 68

Aliases & Descriptionsfor ABCB1

Summariesfor ABCB1

Genomic Locationfor ABCB1

Proteinsfor ABCB1

Protein Domains/Familiesfor ABCB1

Gene Functionfor ABCB1

Pathways & Interactionsfor ABCB1

Drugs & Compoundsfor ABCB1

Transcriptsfor ABCB1

Expression for ABCB1

Orthologsfor ABCB1

Paralogsfor ABCB1

SNPs/Variantsfor ABCB1

Disorders & Mutationsfor ABCB1

Medical Newsfor ABCB1

Publicationsfor ABCB1

Search for ABCB1

Genome Databases showing ABCB1

Other Databases showing ABCB1

Specialized Databases showing ABCB1

Licensable Technologiesfor ABCB1

Servicesfor ABCB1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ABCB1

Summaries
for ABCB1

Genomic Location
for ABCB1

Proteins
for ABCB1

Protein Domains/
Families
for ABCB1

Gene Function
for ABCB1

Pathways & Interactions
for ABCB1

Drugs & Compounds
for ABCB1

Transcripts
for ABCB1

Expression
for ABCB1

Orthologs
for ABCB1

Paralogs
for ABCB1

SNPs/Variants
for ABCB1

Disorders & Mutations
for ABCB1

Medical News
for ABCB1

Publications
for ABCB1

Licensable Technologies
for ABCB1

Services
for ABCB1