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ABCB1 Gene

protein-coding   GIFtS: 73
GCID: GC07M087132

ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1

(Previous name: colchicin sensitivity)
(Previous symbols: PGY1, MDR1, CLCS)
  See ABCB1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 11 2     CD2432
MDR11 2 3 5     GP1702
PGY11 2 3 5     P-GP2
CLCS1 2     Doxorubicin Resistance2
Colchicin Sensitivity1 2     ATP-Binding Cassette Sub-Family B Member 13
Multidrug Resistance Protein 11 2     CD243 Antigen3
P-Glycoprotein 12 3     CLCs5
EC 3.6.3.443 8     IBD135
ABC202     EC 3.6.38

External Ids:    HGNC: 401   Entrez Gene: 52432   Ensembl: ENSG000000855637   OMIM: 1710505   UniProtKB: P081833   

Export aliases for ABCB1 gene to outside databases

Previous GC identifers: GC07M085668 GC07M086731 GC07M086745 GC07M086744 GC07M086777 GC07M086970 GC07M081743


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ABCB1 Gene:
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC)
transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are
divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member
of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein
encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate
specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates
the development of resistance to anticancer drugs. This protein also functions as a transporter in the
blood-brain barrier. (provided by RefSeq, Jul 2008)

GeneCards Summary for ABCB1 Gene:
ABCB1 (ATP-binding cassette, sub-family B (MDR/TAP), member 1) is a protein-coding gene. Diseases associated with ABCB1 include colchicine resistance, and acute non lymphoblastic leukemia. GO annotations related to this gene include xenobiotic-transporting ATPase activity and transporter activity. An important paralog of this gene is ABCB4.

UniProtKB/Swiss-Prot: MDR1_HUMAN, P08183
Function: Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells

summary for ABCB1 Gene:
P-glycoprotein (ABCB1, MDR1) is a well-characterized human ABC transporter that was the first ABC
transporter implicated in multidrug resistance. Normal physiological expression of P-glycoprotein has been
found to prevent uptake of some lipophilic drugs into the brain and other key organs. P-glycoprotein is
frequently overexpressed in cancer cells resulting in drugs being pumped out of the cells faster than they
can enter. This causes a lower concentration of the drug in the cell and reduces the effectiveness of the
drugs in killing cancer cells. Drugs that are affected by classical multidrug resistance include the vinca
alkaloids (vinblastine and vincristine), the anthracyclines (doxorubicin and daunorubicin), the RNA
transcription inhibitor actinomycin D and the microtubule-stabilizing drug taxol.

Gene Wiki entry for ABCB1 (P-glycoprotein) Gene

PharmGKB "VIP" summary for ABCB1


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NC_018918.2  NT_007933.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the ABCB1 gene promoter:
         AML1a   AP-1   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): ABCB1 promoter sequence
   Search Chromatin IP Primers for ABCB1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ABCB1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q21.12   Ensembl cytogenetic band:  7q21.12   HGNC cytogenetic band: 7q21.12

ABCB1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ABCB1 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M087132:  view genomic region     (about GC identifiers)

Start:
87,133,175 bp from pter      End:
87,342,639 bp from pter
Size:
209,465 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 86,464,691-86,673,953     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MDR1_HUMAN, P08183 (See protein sequence)
Recommended Name: Multidrug resistance protein 1  
Size: 1280 amino acids; 141479 Da
Subunit: Interacts with PSMB5
Sequence caution: Sequence=AAM49149.1; Type=Erroneous gene model prediction;
Secondary accessions: A8K294 Q12755 Q14812

Explore the universe of human proteins at neXtProt for ABCB1: NX_P08183

Explore proteomics data for ABCB1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys279, Lys367, Lys515, Lys519, Lys915, Lys1093, Lys1164
  • Glycosylation2 at Asn91, Asn94, Asn99
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for ABCB1 (P08183) (see all 50)
     GWKLTLV  RTVVSLT  KILLLDE  ENIRYGR 


    See ABCB1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000918.2  
    ENSEMBL proteins: 
     ENSP00000265724   ENSP00000399419   ENSP00000444095  
    Reactome Protein details: P08183

    ABCB1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for ABCB1
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for ABCB1
    GenScript Custom Purified and Recombinant Proteins Services for ABCB1
    Novus Biologicals ABCB1 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for ABCB1 

    ABCB1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of ABCB1
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for ABCB1 
    OriGene Antibodies for ABCB1
    OriGene Custom Antibody Services for ABCB1
    Novus Biologicals ABCB1 Antibodies
    Abcam antibodies for ABCB1
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for ABCB1
    LSBio Antibodies in human, mouse, rat for ABCB1

    ABCB1 Assay Products:

    EMD Millipore Kits and Assays for the Analysis of ABCB1
    OriGene Custom Assay Services for ABCB1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ABCB1
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for ABCB1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules
    ABCB: ATP binding cassette transporters / subfamily B

    IUPHAR Guide to PHARMACOLOGY protein family classification: ABCB1
    ABCB subfamily

    Selected InterPro protein domains (see all 6):
     IPR003439 ABC_transporter-like
     IPR027417 P-loop_NTPase
     IPR001140 ABC_transptr_TM_dom
     IPR003593 AAA+_ATPase
     IPR011527 ABC1_TM_dom

    Graphical View of Domain Structure for InterPro Entry P08183

    ProtoNet protein and cluster: P08183

    UniProtKB/Swiss-Prot: MDR1_HUMAN, P08183
    Similarity: Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201)
    subfamily
    Similarity: Contains 2 ABC transmembrane type-1 domains
    Similarity: Contains 2 ABC transporter domains


    Find genes that share domains with ABCB1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MDR1_HUMAN, P08183
    Function: Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells
    Catalytic activity: ATP + H(2)O + xenobiotic(In) = ADP + phosphate + xenobiotic(Out)

         Genatlas biochemistry entry for ABCB1:
    ATP binding cassette superfamily,subfamily B (MDR/TAP),member 1,putatively activated by random chromosomal
    rearrangements,and overexpressed in acute myeloid leukemia and cancer cell lines,by hypomethylation of the
    promoter and altered chromatin structure,up-regulated by P/CAF

         Enzyme Numbers (IUBMB): EC 3.6.3.441 2 EC 3.6.32

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding ----
    GO:0005215transporter activity TAS3022150
    GO:0005515protein binding IPI17088979
    GO:0005524ATP binding IEA--
    GO:0008559xenobiotic-transporting ATPase activity IEA--
         
    Find genes that share ontologies with ABCB1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for ABCB1:
     Decreased viability with pacli 

         12 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Abcb1a):
     behavior/neurological  cardiovascular system  hearing/vestibular/ear  hematopoietic system  homeostasis/metabolism 
     immune system  liver/biliary system  mortality/aging  nervous system  no phenotypic analysis 
     other  reproductive system 

    Find genes that share phenotypes with ABCB1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Abcb1atm1Bor for ABCB1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ABCB1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ABCB1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ABCB1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ABCB1

    miRNA
    Products:
        
    miRTarBase miRNAs that target ABCB1:
    hsa-mir-451a (MIRT005656)

    Block miRNA regulation of human, mouse, rat ABCB1 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate ABCB1:
    hsa-miR-146a*
    SwitchGear 3'UTR luciferase reporter plasmidABCB1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ABCB1
    Predesigned siRNA for gene silencing in human, mouse, rat ABCB1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ABCB1

    Clone
    Products:
         
    OriGene clones in human, mouse for ABCB1 (see all 7)
    OriGene ORF clones in mouse, rat for ABCB1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ABCB1 (NM_000927)
    Sino Biological Human cDNA Clone for ABCB1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ABCB1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ABCB1
    Addgene plasmids for ABCB1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ABCB1
    Browse ESI BIO Cell Lines and PureStem Progenitors for ABCB1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ABCB1

    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-12327) for ABCB1 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MDR1_HUMAN, P08183: Cell membrane; Multi-pass membrane protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    golgi apparatus3
    cytoskeleton2
    cytosol2
    endoplasmic reticulum2
    extracellular2
    mitochondrion2
    nucleus2
    lysosome1
    peroxisome1
    vacuole1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IBA--
    GO:0005886plasma membrane TAS--
    GO:0009986cell surface IDA19384922
    GO:0016020membrane TAS3022150
    GO:0016021integral component of membrane IBA--

    Find genes that share ontologies with ABCB1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ABCB1 About   (see all 28)  
    See pathways by source

    SuperPathContained pathways About
    1ABC-family proteins mediated transport
    ABC-family proteins mediated transport0.69
    ABC transporters0.69
    2Codeine and Morphine Pathway, Pharmacokinetics
    Codeine and Morphine Pathway, Pharmacokinetics0.33
    Codeine and morphine metabolism0.00
    3Gefitinib Pathway, Pharmacokinetics
    Gefitinib Pathway, Pharmacokinetics0.58
    Clopidogrel Pathway, Pharmacokinetics0.43
    Imatinib Pathway, Pharmacokinetics/Pharmacodynamics0.58
    Erlotinib Pathway, Pharmacokinetics0.42
    Warfarin Pathway, Pharmacokinetics0.45
    Tacrolimus/Cyclosporine Pathway, Pharmacokinetics0.00
    4Irinotecan Pathway, Pharmacokinetics
    Irinotecan Pathway, Pharmacokinetics0.69
    Irinotecan Pathway, Pharmacodynamics0.50
    Mycophenolic acid Pathway, Pharmacokinetics/Pharmacodynamics0.50
    Taxane Pathway, Pharmacokinetics0.30
    5Statin Pathway - Generalized, Pharmacokinetics
    Statin Pathway - Generalized, Pharmacokinetics0.50
    Pravastatin Pathway, Pharmacokinetics0.00
    Atorvastatin/Lovastatin/Simvastatin Pathway, Pharmacokinetics0.00


    Find genes that share SuperPaths with ABCB1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for ABCB1
        Hepatic ABC Transporters

    1 Cell Signaling Technology (CST) Pathway for ABCB1
        Glucose / Energy Metabolism

    5 BioSystems Pathways for ABCB1
        Codeine and morphine metabolism
    Nuclear receptors in lipid metabolism and toxicity
    Drug Induction of Bile Acid Pathway
    Integrated Pancreatic Cancer Pathway
    HIF-1-alpha transcription factor network


    2 Reactome Pathways for ABCB1
        ABC-family proteins mediated transport
    Abacavir transmembrane transport

    Selected PharmGKB Pathways for ABCB1 (see all 26)
        Acetaminophen Pathway, Pharmacokinetics
    Atorvastatin/Lovastatin/Simvastatin Pathway, Pharmacokinetics
    Citalopram Pathway, Pharmacokinetics
    Clopidogrel Pathway, Pharmacokinetics
    Codeine and Morphine Pathway, Pharmacokinetics

    3 Kegg Pathways  (Kegg details for ABCB1):
        ABC transporters
    Bile secretion
    MicroRNAs in cancer

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ABCB1 (see all 11): 
              Nephrotoxicity in human mouse rat
              Prostate Cancer in human mouse rat
              Hepatotoxicity in human mouse rat
              Drug Metabolism in human mouse rat
              WNT Signaling Targets in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for ABCB1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ABCB1 (P081831, 2, 3 ENSP000002657244) via UniProtKB, MINT, STRING, and/or I2D (see all 37)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CAV1Q031352, 3, ENSP000003391914MINT-50920 I2D: score=3 STRING: ENSP00000339191
    RNF2Q994961, 3, ENSP000003564804EBI-1057359,EBI-722416 I2D: score=3 STRING: ENSP00000356480
    LAPTM4BQ86VI41, 3EBI-1057359,EBI-3267258 I2D: score=1 
    HAX1O001653, ENSP000003290024I2D: score=2 STRING: ENSP00000329002
    DNAJA1P316893, ENSP000003691274I2D: score=1 STRING: ENSP00000369127
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000086G2/M transition of mitotic cell cycle IDA19384922
    GO:0006810transport TAS3022150
    GO:0006855drug transmembrane transport TAS--
    GO:0042493response to drug TAS3022150
    GO:0044281small molecule metabolic process TAS--

    Find genes that share ontologies with ABCB1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for ABCB1
      Browse compounds at ApexBio 

    Compounds for ABCB1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    PSC 833Inhibitor of P-gp-mediated MDR[121584-18-7]
    XR 9051 HClPotent modulator of P-gp-mediated MDR[180422-22-4]
    Ko 143Potent and selective BCRP inhibitor[461054-93-3]
    ProbenecidMRP inhibitor[57-66-9]
    Elacridar hydrochlorideP-gp inhibitor[143851-98-3]

    Selected DrugBank Compounds for ABCB1 (see all 294)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    VerapamilVerapamil [Usan:Ban:Inn] (see all 4)52-53-9transportersubstrate inhibitor inducer19541926 14985103 12636153 12948019 15504753 10583025 12387747 14698039 8960059 11784143 11454724 10820137 19739078 11082465 12699389 15240100 12649369 11716514 10773005 19944135 15359574 20071452 11602674 19530439 19631272 19125880 15180340 9205004 10997946 19493273 11785684 8621716 9395229 9732409 10571255 11405287 10075817 12954186 12134945 17045309 12569305 11031728 7945455 12604704 10894301 19319690 10087141 11042226 15176077 8094615
    CyclosporineCiclosporin (see all 4)59865-13-3transportersubstrate inhibitor inducer14985103 9914792 12636153 8842452 10891114 12948019 12235267 12880295 15504753 14604686 12387747 8960059 11784143 10820137 10227700 12699389 9262363 11716514 10198227 11602674 19530439 9333100 12975485 7681059 12604693 15023456 9205004 11785684 12724138 9732409 10604964 11405287 14744620 12134945 11961113 17045309 10087141 19319690 7514263
    Vinblastine-- 865-21-4transportersubstrate inhibitor inducer14985103 9751076 12636153 19123050 12948019 9655875 12134946 12235267 8100632 14698039 8960059 12699389 10411602 14706813 11716514 15616150 11961114 19530439 14991868 12107852 19631272 11181899 12604693 10746169 10617675 12081145 11785684 8621716 12724138 1359120 11405287 8862725 12134945 12490309 10087141 19806783
    Quinidine-- 56-54-2transportersubstrate inhibitor19541926 14985103 12636153 12948019 12948010 10820137 9435299 12699389 12649369 9262363 11716514 11504828 19631272 11785684 9927403 1359120 11405287 12954186 12134945 19319690
    Digoxin-- 20830-75-5transportersubstrate inhibitor inducer12948019 12948010 14698039 10227700 12699389 11890691 14706813 15032316 19631272 11181899 10746169 15180340 11785684 12788075 9927403 1359120 19806783
    Paclitaxel7-epi-Paclitaxel (see all 8)33069-62-4transportersubstrate inhibitor14985103 15231674 19123050 12948019 12608535 19903471 15211078 14499271 11716514 11602674 15180340 19493273 10617675 11504826 19427995 9531522
    Daunorubicin-- 20830-81-3transportersubstrate inhibitor inducer20335952 10026252 11602674 10050713 10342576 10746169 10354400 15067695 10617675 11785684 11405287 12134945 10346910 9624121 19806783
    DoxorubicinAdria (see all 4)23214-92-8transportersubstrate inhibitor inducer9914792 19123050 12948019 1356264 12608535 15211078 19739078 9210482 14499271 19631272 10746169 20179710 19255759 11405287
    ImatinibCGP-57148B (see all 4)152459-95-5transportersubstrate inhibitor15970668 16157201 18669873 20423956 19710702 15805252 19785662 12975485 15315971 16890580 15918555
    Vincristine22-Oxovincaleukoblastine (see all 12)57-22-7transportersubstrate inhibitor inducer14985103 15231674 19123050 12608535 11602674 19493273 10617675 19427995 12134945 12490309 9862789

    Selected Novoseek inferred chemical compound relationships for ABCB1 gene (see all 131)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rhodamine 123 94.9 877 7669666 (6), 15067695 (6), 11042226 (5), 16647797 (5) (see all 99)
    verapamil 91.7 832 7749215 (7), 7906257 (6), 7838133 (6), 10870315 (5) (see all 99)
    daunorubicin 91.4 518 10025900 (6), 10444168 (5), 8593279 (4), 7914424 (4) (see all 99)
    psc-833 91.1 166 19763573 (6), 9827923 (3), 8639853 (3), 12949955 (3) (see all 86)
    doxorubicin 90.8 858 8911123 (6), 19035180 (5), 12940627 (4), 11042226 (4) (see all 99)
    vinblastine 89.4 364 8094005 (4), 17982279 (4), 11303953 (4), 17072095 (4) (see all 99)
    gf 120918 88.6 129 10098736 (4), 17936633 (3), 14569063 (3), 9864431 (2) (see all 72)
    tariquidar 87.5 120 19910428 (5), 10510451 (5), 15457126 (4), 11212278 (4) (see all 45)
    vincristine 87.5 372 9719458 (5), 8551799 (5), 15087026 (4), 15371983 (4) (see all 99)
    (125i)iodoarylazidoprazosin 84.6 60 16729976 (5), 16505485 (3), 9380680 (3), 10350482 (2) (see all 25)

    Selected PharmGKB related drug/compound annotations for ABCB1 gene (see all 85)    About this table
    Drug/compound PharmGKB Annotation
    Platinum compoundsCA  
    afatinib
    amitriptylineCA  
    anthracyclines and related substancesCA  
    antidepressantsCA  
    antiepilepticsCA  
    atorvastatinCA  
    bisantreneCA  
    boceprevir
    bosutinib monohydrate



    Find genes that share compounds with ABCB1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ABCB1 gene: 
    NM_000927.4  

    Unigene Cluster for ABCB1:

    ATP-binding cassette, sub-family B (MDR/TAP), member 1
    Hs.489033  [show with all ESTs]
    Unigene Representative Sequence: BC130424
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000265724(uc011khc.2 uc003uiz.2) ENST00000488737 ENST00000491360
    ENST00000475929 ENST00000496821 ENST00000483831 ENST00000482527 ENST00000416177(uc003uja.2 uc010lei.2)
    ENST00000476862 ENST00000543898
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    Additional mRNA sequence: 

    AB208970.1 AF016535.1 AK290159.1 AK308467.1 AY425005.1 BC130424.1 EU852583.1 EU854148.1 
    M14758.1 

    3 DOTS entries:

    DT.112315  DT.102836253  DT.92419387 

    Selected AceView cDNA sequences (see all 71):

    BX645450 AA887211 BM052878 CR595422 AA459824 AY425006 AA455911 CB164676 
    AW119201 AA456377 BI964218 AI476464 BX509020 NM_000927 CD672146 BI964198 
    AY425005 AF345623 AI311081 BI964137 Z41819 BQ717101 BX474069 BQ882401 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ABCB1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGAAATCTA
    ABCB1 Expression
    About this image


    ABCB1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 13) fully expand
     
     Brain (Nervous System)    fully expand to see all 7 entries
             Mature Choroid Plexus Cells Choroid Plexus
             Cerebellum
             Mature brain microvascular endothelial cells
     
     Endothelium (Cardiovascular System)    fully expand to see all 5 entries
             Angioblasts Perineural capillary Plexus
             Mature brain microvascular endothelial cells
     
     Adrenal Gland (Endocrine System)    fully expand to see all 3 entries
             adrenal gland ; glandular cells   
             adrenal cortex   
     
     Epithelial Cells
             Mature Choroid Plexus Cells Choroid Plexus
     
     Neural Tube (Nervous System)
             Angioblasts Perineural capillary Plexus
    ABCB1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ABCB1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.489033

    UniProtKB/Swiss-Prot: MDR1_HUMAN, P08183
    Tissue specificity: Expressed in liver, kidney, small intestine and brain

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ABCB1 (see all 11): 
              Nephrotoxicity in human mouse rat
              Prostate Cancer in human mouse rat
              Hepatotoxicity in human mouse rat
              Drug Metabolism in human mouse rat
              WNT Signaling Targets in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ABCB1 gene from Selected species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Abcb1a1 , 5 ATP-binding cassette, sub-family B (MDR/TAP), member more1, 5 86.07(n)1
    87.61(a)1
      5 (3.43 cM)5
    186711  NM_011076.21  NP_035206.21 
     86600775 
    chicken
    (Gallus gallus)
    Aves --
    ABCB1LB6
    Uncharacterized protein
    Gallus gallus ATP-binding cassette, sub-family B (...
    65(a)
    64(a)
    many ↔ many
    many ↔ many
    2(20547796-20573603)
    2(20547214-20632812)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    70(a)
    1 → many
    6(19282685-19336701)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia MGC762162 hypothetical protein MGC76216 72.53(n)    BC063924.1 
    zebrafish
    (Danio rerio)
    Actinopterygii 570700592   -- 73.44(n)    57070059 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG102263
    Mdr501
    multidrug transporter3
    Multi drug resistance 501
    65(a)
    (best of 4)3
    51.39(n)1
    45.26(a)1
      65A103
    365821  NM_079016.31  NP_523740.31 
    worm
    (Caenorhabditis elegans)
    Secernentea pgp-13
    pgp-91
    multidrug resistance protein3
    pgp-91
    45(a)
    (best of 11)3
    52.1(n)1
    47.2(a)1
      IV(12592000-12599340)3
    1801651  NM_075086.31  NP_507487.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes STE6(YKL209C)4 Plasma membrane ATP-binding cassette (ABC) transporter more   --   11(46295-42423) 853671  NP_012713.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons ABCB41 ABCB4 51.91(n)
    44.53(a)
      819314  NM_130268.3  NP_182223.1 
    rice
    (Oryza sativa)
    Liliopsida Os.201202 Oryza sativa (japonica cultivar-group) cDNA clone0 more 72.39(n)    NM_183599.1 


    ENSEMBL Gene Tree for ABCB1 (if available)
    TreeFam Gene Tree for ABCB1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ABCB1 gene
    ABCB42  ABCB112  ABCB52  
    17 SIMAP similar genes for ABCB1 using alignment to 15 protein entries:     MDR1_HUMAN (see all proteins):
    ABCB4    ABCB5    MDR1    TAP1    ABCB11    NG-TRA
    LOC402251    ABCB6    ABCB9    ABCB10    TAP2    TAP2-G
    CFTR    DKFZp434I2115    ABCB8    ABCB7    ABCG2

    Find genes that share paralogs with ABCB1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Polymorphic Variants from UniProtKB/Swiss-Prot
    MDR1_HUMAN, P08183: Genetic variation in ABCB1 may play a role in patients who do not respond to drug treatment


    Selected SNPs for ABCB1 (see all 4362)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0357374
    A colorectal cancer sample4--see VAR_0357372 K N mis40--------
    rs11285011,2,,4
    Cpathogenic190502777(-) TGAAGG/TAATTG 2 G V mis12Minor allele frequency- T:0.00NA 4
    rs1994736941,2
    Cuntested190650334(-) AATTAC/TTTTTT 2 -- us2k10--------
    rs1994736961,2
    Cuntested190651125(+) AACCTA/GTGATT 2 -- us2k10--------
    rs577000181,2
    C--81808928(+) AAAAA-/A/AAA 
            
    TCTAT
    1 -- int11NA 2
    rs2016470131,2
    C--81818268(+) ACTTTC/TTTTTT 1 -- int10--------
    rs41487461,2
    C,F--86478665(-) CACGAA/-CATGG 1 -- int17Minor allele frequency- -:0.04NS NA 170
    rs284017771,2
    C,F--86481049(-) AAAAA-/ATGATG 1 -- int15Minor allele frequency- A:0.11NS 190
    rs283819581,2
    C,F--86496352(-) AAAAA-/TCAAGG 1 -- int16Minor allele frequency- T:0.31NS CSA 152
    rs722003001,2
    C--86496353(+) CTTGT-/ATTTTA 1 -- int10--------

    HapMap Linkage Disequilibrium report for ABCB1 (87133175 - 87342639 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for ABCB1 (see all 12):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2666273CNV Deletion23128226
    esv2734776CNV Deletion23290073
    esv2734775CNV Deletion23290073
    nsv888692CNV Loss21882294
    dgv7384n71CNV Loss21882294
    esv28195CNV Loss19812545
    nsv888695CNV Loss21882294
    esv7655CNV Loss19470904
    nsv464622CNV Gain19166990
    nsv464623CNV Gain19166990

    Human Gene Mutation Database (HGMD): ABCB1
    Site Specific Mutation Identification with PCR Assays
    2 Copy Number PCR Panels containing ABCB1:
    Oncogenes & Tumor Suppressor Genes 384HC
    Prostate Cancer
    SeqTarget long-range PCR primers for resequencing ABCB1
    DNA2.0 Custom Variant and Variant Library Synthesis for ABCB1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 171050   
    OMIM disorders: 120080  612244  
    UniProtKB/Swiss-Prot: MDR1_HUMAN, P08183
  • Inflammatory bowel disease 13 (IBD13) [MIM:612244]: A chronic, relapsing inflammation of the
    gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis
    phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most
    frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may
    contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the
    inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not
    observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints. Note=Disease
    susceptibility is associated with variations affecting the gene represented in this entry

  • Selected diseases for ABCB1 (see all 22):    
    About MalaCards
    colchicine resistance    acute non lymphoblastic leukemia    ovarian cystadenocarcinoma    inflammatory bowel disease 13
    paralytic ileus    engraftment syndrome    neonatal abstinence syndrome    soft tissue sarcoma
    uterine sarcoma    vaginitis    microsporidiosis    5-fluorouracil toxicity
    ileus    plasmablastic lymphoma    cannabis dependence    postural hypotension
    warfarin sensitivity    pervasive developmental disorder    myeloma    acute myeloid leukemia

    9 diseases from the University of Copenhagen DISEASES database for ABCB1:
    Leukemia     Breast cancer     Lung cancer     Ovarian cancer
    Colorectal cancer     Carcinoma     Lymphoma     Hepatocellular carcinoma
    Neonatal abstinence syndrome

    Find genes that share disorders with ABCB1           About GenesLikeMe

    Selected Novoseek inferred disease relationships for ABCB1 gene (see all 89)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 75.3 928 19369960 (4), 9476146 (4), 17290610 (4), 11245443 (4) (see all 99)
    leukemia 75.2 389 9439046 (4), 14642128 (4), 1859877 (3), 9594630 (3) (see all 99)
    tumors 72.3 1527 17895794 (6), 9815963 (6), 1359152 (6), 18300948 (5) (see all 99)
    breast cancer 70.3 601 8679460 (7), 10092063 (6), 16200770 (4), 8068207 (4) (see all 99)
    colchicine resistance 69.4 8 11284688 (1), 1968359 (1), 8599208 (1), 15049699 (1) (see all 5)
    aml adult 68 26 19291917 (3), 10419897 (3), 10374270 (2), 17038891 (2) (see all 14)
    acute leukemia 67.8 134 8477061 (6), 16086884 (5), 15512810 (4), 17538395 (4) (see all 73)
    colon carcinoma 65.2 92 12894558 (3), 8207045 (3), 7476894 (3), 8103760 (3) (see all 53)
    ovarian carcinoma 60 67 10767994 (5), 10537344 (4), 7799045 (3), 9639738 (3) (see all 35)
    secondary aml 58.2 11 1283551 (1), 8075575 (1), 9129038 (1), 8628017 (1) (see all 11)

    Genetic Association Database (GAD): ABCB1
    Human Genome Epidemiology (HuGE) Navigator: ABCB1 (740 documents)

    Export disorders for ABCB1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ABCB1 gene, integrated from 10 sources (see all 4859):
    (articles sorted by number of sources associating them with ABCB1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Adenosine triphosphate-binding cassette B1 (ABCB1) (multidrug resistance 1) G2677T/A gene polymorphism is associated with high risk of lung cancer. (PubMed id 17120199)1, 4, 7, 9 Gervasini G....Benitez J. (Cancer 2006)
    2. Influence of drug transporters and UGT polymorphisms on pharmacokinetics of phenolic glucuronide metabolite of mycophenolic acid in Japanese renal transplant recipients. (PubMed id 18695635)1, 4, 7, 9 Miura M....Suzuki T. (Ther Drug Monit 2008)
    3. Influence of pharmacogenetics on response and toxicity in breast cancer patients treated with doxorubicin and cyclophosphamide. (PubMed id 20179710)1, 4, 7, 9 Bray J....Boddy A.V. (Br. J. Cancer 2010)
    4. Pharmacogenetic characteristics of indinavir, zidovudine, and lamivudine therapy in HIV-infected adults: a pilot study. (PubMed id 16791115)1, 4, 7, 9 Anderson P.L....Fletcher C.V. (J. Acquir. Immune Defic. Syndr. 2006)
    5. Effect of MDR1 C3435T polymorphism on lansoprazole in healthy Japanese subjects. (PubMed id 19238367)1, 4, 7 Kodaira C....Furuta T. (Eur. J. Clin. Pharmacol. 2009)
    6. Integrated pharmacogenetic prediction of irinotecan pharmacokinetics and toxicity in patients with advanced non-small cell lung cancer. (PubMed id 18221820)1, 4, 7 Han J.Y....Lee J.S. (Lung Cancer 2009)
    7. Polymorphisms in the drug transporter gene ABCB1 predict antidepressant treatment response in depression. (PubMed id 18215618)1, 4, 7 Uhr M....Holsboer F. (Neuron 2008)
    8. Dose-dependent effects of the 3435 C&gt;T genotype of ABCB1 gene on the steady-state plasma concentration of fluvoxamine in psychiatric patients. (PubMed id 17417072)1, 4, 7 Fukui N....Someya T. (Ther Drug Monit 2007)
    9. MDR1 Ala893 polymorphism is associated with inflammatory bowel disease. (PubMed id 14610718)1, 2, 4 Brant S.R.... Cho J.H. (Am. J. Hum. Genet. 2003)
    10. Frequency of single nucleotide polymorphisms in the P-glycoprotein drug transporter MDR1 gene in white subjects. (PubMed id 11240981)1, 2, 4 Cascorbi I.... Roots I. (Clin. Pharmacol. Ther. 2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5243 HGNC: 40 AceView: ABCB1 Ensembl:ENSG00000085563 euGenes: HUgn5243
    ECgene: ABCB1 Kegg: 5243 H-InvDB: ABCB1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ABCB1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ABCB1 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/abcb1/
    SHMPDhttp://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=ABCB1
    Wikipedia http://en.wikipedia.org/wiki/P-glycoprotein
    ABCMdbhttp://abcmutations.hegelab.org/proteinDetails?uniprot_id=P08183

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ABCB1 gene:
    Search GeneIP for patents involving ABCB1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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