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Aliases & Descriptions for ABCA9
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| DKFZp686F2450 2 | | EST640918 1, 2 | | MGC75415 2 |
| | | Descriptions |
|---|
| ATP-binding cassette A9 2 | | ATP-binding cassette, sub-family A (ABC1), member 9 2 | | ATP-binding cassette, sub-family A, member 9 2 |
|
| | Search outside databases for aliases for ABCA9 genePrevious GC identifers: GC17M066770 GC17M069931 GC17M067435 GC17M067568 |
Summaries for ABCA9(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for ABCA9: This gene is a member of the superfamily of ATP-binding cassette (ABC) transporters and the encoded protein contains two transmembrane domains and two nucleotide binding folds. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This gene is a member of the ABC1 subfamily and is clustered with four other ABC1 family members on chromosome 17q24. Transcriptional expression of this gene is induced during monocyte differentiation into macrophages and is suppressed by cholesterol import. [provided by RefSeq] UniProtKB/Swiss-Prot: ABCA9_HUMAN, Q8IUA7Function: May play a role in monocyte differentiation and lipid homeostasisGene Wiki entry for ABCA9 |
Genomic Location for ABCA9
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the ABCA9 gene 
Entrez Gene cytogenetic band: 17q24.2 Ensembl cytogenetic band: 17q24.2 HGNC cytogenetic band: 17q24ABCA9 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17M064482:
(about GC identifiers)
Start:
|
64,482,368 bp from pter |
End:
|
64,568,731 bp from pter |
Size:
|
86,364 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000017.9 NT_010641.15
| Proteins for ABCA9
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: ABCA9_HUMAN, Q8IUA7 (See
protein sequence)Recommended Name: ATP-binding cassette sub-family A member 9 Size: 1624 amino acids; 184362 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Developmental stage: Expressed in fetal tissues with higher expression in fetal heart and kidney
Secondary accessions: Q6P655 Q8N2S4 Q8WWZ5 Q96MD8Alternative splicing: 5 isoforms: Q8IUA7-1 Q8IUA7-2 Q8IUA7-3 Q8IUA7-4 Q8IUA7-5 Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_525022.2
ENSEMBL proteins: ENSP00000342216 ENSP00000359767
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
2 Gene Ontology (GO) cellular component terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016020 | membrane |
IEA | -- | | GO:0016021 | integral to membrane |
IEA | -- | About this table
Antibodies for ABCA9: Assays for ABCA9: | Protein
Domains/ Families for ABCA9(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q8IUA7
ProtoNet protein and cluster: Q8IUA7 UniProtKB/Swiss-Prot: ABCA9_HUMAN, Q8IUA7Similarity: Belongs to the ABC transporter family. ABCA subfamilySimilarity: Contains 2 ABC transporter domains | Gene Function for ABCA9
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|                OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_172386
Applied Biosystems Silencer® siRNAs for ABCA9
Sigma-Aldrich siRNA and siRNA Panels for ABCA9  Sigma-Aldrich shRNA for ABCA9  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_080283                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_080283                                  untagged cDNA clones in CMV expression vector (see all 2): AK095538 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_080283
UniProtKB/Swiss-Prot: ABCA9_HUMAN, Q8IUA7Function: May play a role in monocyte differentiation and lipid homeostasisInduction: Up-regulated during monocyte differentiation into macrophages. Down-regulated by cholesterol loading of macrophages3 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for ABCA9
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
Gene Network CentralTM Interacting Genes and Proteins Network for ABCA9 
2 Interacting proteins for ABCA9 (ENSP000003422163) via UniProtKB, MINT, and/or STRINGAbout this table
1 Gene Ontology (GO) biological process term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006810 | transport |
IEA | -- | About this table
|
Drugs & Compounds for ABCA9(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for ABCA9
|
Transcripts for ABCA9(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|                OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_172386
Sigma-Aldrich siRNA and siRNA Panels for ABCA9  Sigma-Aldrich shRNA for ABCA9  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_080283 REFSEQ mRNAs for ABCA9 gene: NM_080283.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_080283               OriGene GFP tagged cDNA clone in CMV expression vector: NM_080283                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_080283                                  untagged cDNA clones in CMV expression vector (see all 2): AK095538  Additional cDNA sequence: AF423307.1 AK057068.1 AK074491.1 AK122687.1 AL833712.1 AY028899.1 BC062472.1 CR627382.1 9 DOTS entries: DT.75117570 DT.410492 DT.100027018 DT.410491 DT.75153861 DT.100704618 DT.100736998 DT.120986999 DT.75122701 24/57 AceView cDNA sequences (see all 57
):AL698804 F00423 NM_172386 BC062472 NM_080283 BX280456 BX281489 AF423307 AI627862 BM992857 AI372047 BX496612 T41066 AY028899 W84726 BF513667 AL833712 AW130042 BU072174 AW296945 AI446543 AK057068 AK122687 BU076154
highest scoring ESTs for ABCA9:AI284184 AK057068 AY028899 AA027211 AA027212 AA148691 AA148692 AA248948 AF423307 AI822115 Unigene Cluster for ABCA9: ATP-binding cassette, sub-family A (ABC1), member 9 Hs.131686 [show with all ESTs]Unigene Representative Sequence: NM_080283
GeneLoc Exon Structure
2 Ensembl transcripts including schematic representations: ENST00000340001
ENST00000370732
|
Expression for ABCA9
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| ABCA9 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for ABCA9
1 / 2 / 3 10 probe-sets matching ABCA9 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: --
SOURCE GeneReport for Unigene cluster: Hs.131686 UniProtKB/Swiss-Prot: ABCA9_HUMAN, Q8IUA7Tissue specificity: Widely expressed with higher expression in heart |
Orthologs for ABCA9
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for ABCA9 gene from 5 species
| Organism |
Gene |
Locus |
Description |
Human Similarity |
NCBI accessions |
dog (Canis familiaris) |
ABCA91 |
-- |
ATP-binding cassette, sub-family A (ABC1), member 9 |
87.44(n) 85.59(a) |
611016 XM_848625.1 XP_853718.1 |
chimpanzee (Pan troglodytes) |
ABCA91 |
-- |
ATP-binding cassette, sub-family A (ABC1), member 9 |
99.27(n) 99.12(a) |
742781 XM_001146190.1 XP_001146190.1 |
cow (Bos taurus) |
ABCA91 |
-- |
ATP-binding cassette, sub-family A (ABC1), member 9 |
81.54(n) 77.26(a) |
504278 XM_865176.2 XP_870269.2 |
rat (Rattus norvegicus) |
Abca91 |
-- |
ATP-binding cassette, sub-family A (ABC1), member 9 |
78.73(n) 74.72(a) |
287788 XM_221101.4 XP_221101.4 |
mouse (Mus musculus) |
Abca91, 5 |
115
|
ATP-binding cassette, sub-family A (ABC1), member 91, 5 |
81.57(n)1 78.73(a)1 |
2172621 NM_147220.11 NP_671753.11 AA1708685 AA1728355 (see all 16) |
About this table Species with no ortholog for ABCA9
ENSEMBL Gene Tree for ABCA9 | Paralogs for ABCA9(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for ABCA9 gene
- ABCA102 ABCA62 ABCA52 ABCA82
|
SNPs/Variants for ABCA9(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for ABCA9 (up to first 250kb)
|
Disorders & Mutations for ABCA9
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 612507
|
Medical News for ABCA9(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for ABCA9 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 9 PubMed articles for ABCA9 gene: |
Search for ABCA9
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing ABCA9
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing ABCA9
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ABCA9(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for ABCA9(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for ABCA9:

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