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ABCA7 Gene

protein-coding GIFtS: 57

GC19P000992

ATP-binding cassette, sub-family A (ABC1), member 7
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
ABCA-SSN ^², ³
ABCX ^¹, ², ⁵
FLJ40025 ^²

Descriptions
ATP-binding cassette, sub-family A (ABC1), member 7 ^²
ATP-binding cassette, sub-family A, member 7 ^²
Autoantigen SS-N ^², ³
Macrophage ABC transporter ^², ³

External Ids
HGNC: 37¹
Entrez Gene: 10347²
UniProtKB: Q8IZY2³
Ensembl: ENSG00000064687⁷

Search outside databases for aliases for ABCA7 gene

Previous GC identifers: GC19P001116 GC19P000981

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for ABCA7:

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC)

transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes.

ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20,

White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the

only major ABC subfamily found exclusively in multicellular eukaryotes. This full transporter has

been detected predominantly in myelo-lymphatic tissues with the highest expression in peripheral

leukocytes, thymus, spleen, and bone marrow. The function of this protein is not yet known;

however, the expression pattern suggests a role in lipid homeostasis in cells of the immune

system. [provided by RefSeq]

UniProtKB/Swiss-Prot: ABCA7_HUMAN, Q8IZY2

Function: Plays a role in phagocytosis by macrophages of apoptotic cells. Binds APOA1 and may

function in apolipoprotein-mediated phospholipid efflux from cells. May also mediate cholesterol

efflux. May regulate cellular ceramide homeostasis during keratinocytes differentiation

Gene Wiki entry for ABCA7

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ABCA7 gene

Entrez Gene cytogenetic band: 19p13.3 Ensembl cytogenetic band: 19p13.3 HGNC cytogenetic band: 19p13.3

ABCA7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19P000992: (about GC identifiers)

Start:	991,102 bp from pter
End:	1,016,571 bp from pter
Size:	25,470 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000019.8 NT_011255.14

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: ABCA7_HUMAN, Q8IZY2 (See protein sequence)

Recommended Name: ATP-binding cassette sub-family A member 7

Size: 2146 amino acids; 234350 Da

Subcellular location: Cell membrane; Multi-pass membrane protein. Golgi apparatus membrane;

Multi-pass membrane protein. Endosome membrane; Multi-pass membrane protein. Note=Localizes to

cell membrane ruffles and phagocytic cups of macrophages stimulated with C1q or apoptotic cells.

Localizes to the cytoplasm of resting macrophages, probably in Golgi and endosomes. Localizes to

the apical brush border of cells in the proximal tubules of kidney. Isoform 2 may localize to the

endoplasmic reticulum

Developmental stage: Expressed in fetal tissues. Strongly expressed in fetal liver

Secondary accessions: Q96S58 Q9BZC4 Q9NR73 Q9UKP8

Alternative splicing: 2 isoforms: Q8IZY2-1 Q8IZY2-2

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_061985.2

ENSEMBL proteins:

ENSP00000263094

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (ABCA7)
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5/9 Gene Ontology (GO) cellular component terms (links to tree view) (see all 9 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000139	Golgi membrane	IEA	--
GO:0005622	intracellular	IEA	--
GO:0005768	endosome	IEA	--
GO:0005794	Golgi apparatus	IEA	--
GO:0005886	plasma membrane	IEA	--

About this table

Antibodies for ABCA7:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (ABCA7), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for ABCA7

Assays for ABCA7:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q8IZY2

ProtoNet protein and cluster: Q8IZY2

UniProtKB/Swiss-Prot: ABCA7_HUMAN, Q8IZY2

Similarity: Belongs to the ABC transporter family. ABCA subfamily

Similarity: Contains 2 ABC transporter domains

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ABCA7)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ABCA7)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_019112

Applied Biosystems Silencer® siRNAs for ABCA7

Sigma-Aldrich siRNA and siRNA Panels for ABCA7

Sigma-Aldrich shRNA for ABCA7

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_019112
Myc/DDK tagged cDNA clone in CMV expression vector: NM_019112
untagged cDNA clones in CMV expression vector (see all 2): NM_019112

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_019112

UniProtKB/Swiss-Prot: ABCA7_HUMAN, Q8IZY2

Function: Plays a role in phagocytosis by macrophages of apoptotic cells. Binds APOA1 and may

function in apolipoprotein-mediated phospholipid efflux from cells. May also mediate cholesterol

efflux. May regulate cellular ceramide homeostasis during keratinocytes differentiation

Induction: Up-regulated in macrophages upon cholesterol uptake and inversely regulated upon

cholesterol deloading from the cells (at protein level). Up-regulated in keratinocytes during

terminal differentiation

3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Abca7):

adipose tissue

homeostasis/metabolism

renal/urinary system

5 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0005215	transporter activity	TAS	10873640
GO:0005524	ATP binding	TAS	10873640
GO:0005548	phospholipid transporter activity	IEA	--
GO:0016887	ATPase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for ABCA7

5/10 Interacting proteins for ABCA7 (ENSP00000263094³) via UniProtKB, MINT, and/or STRING (see all 10 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
APOA1	ENSP00000364469³	STRING (score=.972)
ABCD4	ENSP00000349396³	STRING (score=.967)
ABCF2	ENSP00000222388³	STRING (score=.959)
ABCD2	ENSP00000310688³	STRING (score=.952)
ABCA2	ENSP00000347205³	STRING (score=.92)

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3 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006810	transport	IEA	--
GO:0006909	phagocytosis	IEA	--
GO:0033700	phospholipid efflux	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for ABCA7
4 Novoseek chemical compound relationships for ABCA7 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
sterol	60.26	3	16788211 (2)
cholesterol	50.92	15	14570867 (4), 16788211 (3), 18429932 (3), 15930518 (1) (see all 6)
phospholipid	50.61	4	14570867 (2), 16788211 (1)
lipid	37.57	6	16788211 (1), 10873640 (1), 17973979 (1), 14570867 (1) (see all 5)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ABCA7)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ABCA7)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_019112

Sigma-Aldrich siRNA and siRNA Panels for ABCA7

Sigma-Aldrich shRNA for ABCA7

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_019112

REFSEQ mRNAs for ABCA7 gene:

NM_019112.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_019112

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_019112
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_019112
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_019112

Additional cDNA sequence:

AB055390.1 AF140342.1 AF250238.1 AF328787.1 AK097344.1 AK301108.1 AK310127.1 AK310909.1

AL137481.1

12 DOTS entries:

DT.100773838 DT.87046747 DT.100026519 DT.100773843 DT.202026 DT.408328 DT.121417280 DT.97815725

DT.121417268 DT.121417290 DT.121417293 DT.95242964

24/99 AceView cDNA sequences (see all 99 ):

AF140342 AF328787 BQ955522 BQ959013 AK097344 BU528031 CD629704 BE793677

AI076219 NM_019112 BM709682 BG674537 AA703073 BU734175 CD629714 CD629705

BU675136 AI831940 AI668632 NM_033308 CD629699 AI733552 BU430216 BQ639376

highest scoring ESTs for ABCA7:

AI419066 AA181557 AA811169 AB055390 AF250238 AF328787 AI076219 AI248699 AI374872 AI400695

Unigene Cluster for ABCA7:

ATP-binding cassette, sub-family A (ABC1), member 7

Hs.134514 [show with all ESTs]

Unigene Representative Sequence: NM_019112

GeneLoc Exon Structure

5/11 Alternative Splicing Database (ASD) splice patterns (SP) for ABCA7 (see all 11 )

ExUns:	1a	·	1b	^	2a	·	2b	·	2c	^	3	^	4	^	5a	·	5b	·	5c	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14	^	15	^	16	^	17a	·	17b	^	18	^	19	^	20	^
SP1:																																			-
SP2:
SP3:
SP4:
SP5:

ExUns:	21	^	22	^	23	^	24	^	25a	·	25b	^	26	^	27a	·	27b	^	28	^	29	^	30	^	31a	·	31b	^	32	^	33	^	34	^	35a	·	35b	·	35c	^	36	^	37a	·	37b	^	38	^	39	^	40	^
SP1:
SP2:																																											-
SP3:
SP4:																					-
SP5:																					-

ExUns:	41	^	42	^	43a	·	43b	^	44	^	45a	·	45b	·	45c	^	46	^	47	^	48
SP1:													-		-
SP2:													-		-
SP3:															-
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for ABCA7

1 Ensembl transcript including schematic representation:

ENST00000263094

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

ABCA7 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ABCA7

¹ / ² / ³

5 probe-sets matching ABCA7 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
76807_at²^{, 3}	U95-E	1	1.00	1.00	0.97	1.13	AI419066	1.00	1.00	1.00	1
51079_at²^{, 3}	U95-C	1	0.69	1.00	0.92	0.90	AI668632	0.60	1.00	0.82	1
85763_at²^{, 3}	U95-E	1	0.31	1.00	-0.02	0.99	T87799	0.60	1.00	0.82	1
219577_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_019112	0.60	1.00	0.82	1
219577_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GAGGCCGCCT

SOURCE GeneReport for Unigene cluster: Hs.134514
UniProtKB/Swiss-Prot: ABCA7_HUMAN, Q8IZY2
Tissue specificity: Expressed in leukocytes (at protein level). Widely expressed. Highly expressed
in myelo-lymphatic tissues including peripheral leukocytes, thymus, spleen and bone marrow.
Isoform 2 is more abundant in lymph node, spleen, thymus and trachea than isoform 1 which is more
strongly expressed in brain and bone marrow

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ABCA7 gene from 5/6 species (see all 6 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ABCA7¹	--	ATP-binding cassette, sub-family A (ABC1), member 7	82.6(n) 80.95(a)	485090 XM_542208.2 XP_542208.2
chimpanzee (Pan troglodytes)	ABCA7¹	--	ATP-binding cassette, sub-family A (ABC1), member 7	98.74(n) 98.63(a)	455538 XM_512226.2 XP_512226.2
cow (Bos taurus)	ABCA7¹	--	ATP-binding cassette, sub-family A (ABC1), member 7	83.22(n) 83.29(a)	511762 XM_589159.3 XP_589159.3
rat (Rattus norvegicus)	Abca7¹	--	ATP-binding cassette, sub-family A (ABC1), member 7	78(n) 78.97(a)	299609 NM_207598.1 NP_997481.1
mouse (Mus musculus)	Abca7^{1, 5}	10 (44.00 cM)⁵	ATP-binding cassette, sub-family A (ABC1), member 7^{1, 5}	78.04(n)¹ 78.84(a)¹	27403¹ NM_013850.1¹ NP_038878.1¹ AA049486⁵ AC087114⁵ (see all 18)

About this table Species with no ortholog for ABCA7

ENSEMBL Gene Tree for ABCA7

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for ABCA7 gene

ABCA4² ABCA1²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/258 NCBI SNPs in ABCA7 are shown (see all 258 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 97)

AB	SNP ID	Valid	Chr 19 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs3764642^1,2	A,C,F,H	991046(+)	`GGCAGG/ATCGCC`	1	--	ng5¹		5	NA EU WA	318
	rs3764647^1,2	C,F,H	995712(+)	`GGGGCA/GCCTGG`	1	H/R	mis¹ ese³		5	EA EU WA	1872
	rs3752246^1,2	C,F,H	1007492(+)	`TGAGGC/GTGCAC`	1	G/A	mis¹ ese³		12	EA NA EU WA	2468
	rs4147918^1,2	C,F,H	1009176(+)	`GAAACA/GGGTCT`	1	Q/R	mis¹ ese³		12	EU EA WA	1260
	rs3752232^1,2	C,F,H	994748(+)	`AGCTCA/GCCCTG`	1	T/A	mis¹ ese³		5	EA EU WA	1918
	rs3752229^1,2	C,F,H	992352(+)	`TGCCCA/GGTCTC`	1	--	ut5¹		9	EA EU WA	2330
--	rs3752239^1,2	C,F,H	998537(+)	`GCACAA/CCGTGG`	1	N/T	mis¹ ese³		3	EA	1634
	rs3752233^1,2	C,F,H	996173(+)	`CGTGCG/ACATCA`	1	H/R	mis¹ ese³		5	EA EU WA	1884
	rs3745842^1,2	A,C,F	1006191(-)	`CGGGCC/TGGCTA`	1	R/Q	mis¹ ese³		4	EA NA	1626
	rs3764645^1,2	C,F,H	993809(+)	`CGCTGA/GGGACC`	1	E/G	mis¹ ese³		8	EA WA EU	2220

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HapMap Linkage Disequilibrium images for ABCA7 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 605414

Genetic Association Database: ABCA7
Human Genome Epidemiology Navigator: ABCA7 (3 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/24 PubMed articles for ABCA7 gene (see all 24 ):

Identification of a novel human sterol-sensitive ATP-binding cassette transporter (ABCA7). (PubMed id 10873640)^{1, 3, 4} Kaminski W.E....Schmitz G. (2000)
Human ABCA7 supports apolipoprotein-mediated release of cellular cholesterol and phospholipid to generate high density lipoprotein. (PubMed id 14570867)^{1, 3, 4} Abe-Dohmae S....Yokoyama S. (2004)
Homozygosity for the 168His variant of the minor histocompatibility antigen HA-1 is associated with reduced risk of primary Sjogren's syndrome. (PubMed id 15593299)^{3, 6} Harangi M....Schmitz G. (2005)
Adenosine triphosphate binding cassette (ABC) transporters are expressed and regulated during terminal keratinocyte differentiation: a potential role for ABCA7 in epidermal lipid reorganization. (PubMed id 12925201)^{3, 4} Kielar D.... Schmitz G. (2003)
Posttranscriptional regulation of human ABCA7 and its function for the apoA-I-dependent lipid release. (PubMed id 14592415)^{3, 4} Ikeda Y.... Ueda K. (2003)
ATP-binding cassette transporter A7 (ABCA7) binds apolipoprotein A-I and mediates cellular phospholipid but not cholesterol efflux. (PubMed id 12917409)^{3, 4} Wang N.... Tall A.R. (2003)
Catalog of 605 single-nucleotide polymorphisms (SNPs) among 13 genes encoding human ATP-binding cassette transporters: ABCA4, ABCA7, ABCA8, ABCD1, ABCD3, ABCD4, ABCE1, ABCF1, ABCG1, ABCG2, ABCG4, ABCG5, and ABCG8. (PubMed id 12111378)^{3, 4} Iida A.... Nakamura Y. (2002)
Comparative analysis of the promoter structure and genomic organization of the human and mouse ABCA7 gene encoding a novel ABCA transporter. (PubMed id 11435699)^{3, 4} Broccardo C.... Chimini G. (2001)
Human ABCA1 contains a large amino-terminal extracellular domain homologous to an epitope of Sjogren's Syndrome. (PubMed id 11355874)^{3, 4} Tanaka A.R.... Ueda K. (2001)
Genomic organization of the human cholesterol-responsive ABC transporter ABCA7: tandem linkage with the minor histocompatibility antigen HA-1 gene. (PubMed id 11095984)^{3, 4} Kaminski W.E.... Schmitz G. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 10347	HGNC: 37	AceView: ABCA7	Ensembl:ENSG00000064687	euGenes: HUgn10347
ECgene: ABCA7	H-InvDB: ABCA7

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for ABCA7
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for ABCA7:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ABCA7-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ABCA7		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for ABCA7		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

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	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
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	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
ABCA7 Gene at Home site.
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ABCA7 Gene

protein-coding GIFtS: 57

Aliases &
Descriptions
for ABCA7

Summaries
for ABCA7

Genomic Location
for ABCA7

Proteins
for ABCA7

Protein Domains/
Families
for ABCA7

Gene Function
for ABCA7

Pathways & Interactions
for ABCA7

Drugs & Compounds
for ABCA7

Transcripts
for ABCA7

Expression
for ABCA7

Orthologs
for ABCA7

Paralogs
for ABCA7

SNPs/Variants
for ABCA7

Disorders & Mutations
for ABCA7

Medical News
for ABCA7

Publications
for ABCA7

Search for ABCA7

Genome Databases showing ABCA7

Other Databases showing ABCA7

Specialized Databases showing ABCA7

Licensable Technologies
for ABCA7

Services
for ABCA7

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ABCA7 Gene

protein-coding GIFtS: 57

Aliases & Descriptionsfor ABCA7

Summariesfor ABCA7

Genomic Locationfor ABCA7

Proteinsfor ABCA7

Protein Domains/Familiesfor ABCA7

Gene Functionfor ABCA7

Pathways & Interactionsfor ABCA7

Drugs & Compoundsfor ABCA7

Transcriptsfor ABCA7

Expression for ABCA7

Orthologsfor ABCA7

Paralogsfor ABCA7

SNPs/Variantsfor ABCA7

Disorders & Mutationsfor ABCA7

Medical Newsfor ABCA7

Publicationsfor ABCA7

Search for ABCA7

Genome Databases showing ABCA7

Other Databases showing ABCA7

Specialized Databases showing ABCA7

Licensable Technologiesfor ABCA7

Servicesfor ABCA7

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ABCA7

Summaries
for ABCA7

Genomic Location
for ABCA7

Proteins
for ABCA7

Protein Domains/
Families
for ABCA7

Gene Function
for ABCA7

Pathways & Interactions
for ABCA7

Drugs & Compounds
for ABCA7

Transcripts
for ABCA7

Expression
for ABCA7

Orthologs
for ABCA7

Paralogs
for ABCA7

SNPs/Variants
for ABCA7

Disorders & Mutations
for ABCA7

Medical News
for ABCA7

Publications
for ABCA7

Licensable Technologies
for ABCA7

Services
for ABCA7