ABCA7 Gene
protein-coding GIFtS: 60
GCID: GC19P001040
|
|
ATP-binding cassette, sub-family A (ABC1), member 7
| |
Aliases
for ABCA7 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| ATP-Binding Cassette, Sub-Family A (ABC1), Member 71 2 | | ATP-Binding Cassette Sub-Family A Member 72 | | ABCX1 2 5 | | EC 2.2.1.18 | | Autoantigen SS-N2 3 | | EC 3.6.38 | | Macrophage ABC Transporter2 3 | | EC 3.6.3.418 | | ABCA-SSN2 3 | | |
Export aliases for ABCA7 gene to outside databasesPrevious GC identifers: GC19P001116 GC19P000981 GC19P000992 GC19P000812 |
Summaries
for ABCA7 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for ABCA7:
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABCproteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into sevendistinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily.Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes.This full transporter has been detected predominantly in myelo-lymphatic tissues with the highest expression inperipheral leukocytes, thymus, spleen, and bone marrow. The function of this protein is not yet known; however, theexpression pattern suggests a role in lipid homeostasis in cells of the immune system. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: ABCA7_HUMAN, Q8IZY2Function: Plays a role in phagocytosis by macrophages of apoptotic cells. Binds APOA1 and may function inapolipoprotein-mediated phospholipid efflux from cells. May also mediate cholesterol efflux. May regulate cellularceramide homeostasis during keratinocytes differentiation
Gene Wiki entry for ABCA7
|
Genomic Views
for ABCA7 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011255.14
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ABCA7 gene promoter:
Sp1 Tal-1 Pax-2a AP-4 XBP-1 Tal-1beta E47 ITF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for ABCA7
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ABCA7 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19p13.3 Ensembl cytogenetic band: 19p13.3 HGNC cytogenetic band: 19p13.3ABCA7 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P001040: view genomic region
(about GC identifiers)
Start:
|
1,040,102 bp from pter |
End:
|
1,065,571 bp from pter |
Size:
|
25,470 bases |
Orientation:
|
plus strand |
|
Proteins
for ABCA7 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ABCA7_HUMAN, Q8IZY2 (See
protein sequence)Recommended Name: ATP-binding cassette sub-family A member 7 Size: 2146 amino acids; 234350 Da
Subcellular location: Cell membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membraneprotein. Endosome membrane; Multi-pass membrane protein. Note=Localizes to cell membrane ruffles and phagocytic cupsof macrophages stimulated with C1q or apoptotic cells. Localizes to the cytoplasm of resting macrophages, probably inGolgi and endosomes. Localizes to the apical brush border of cells in the proximal tubules of kidney. Isoform 2 maylocalize to the endoplasmic reticulum
Developmental stage: Expressed in fetal tissues. Strongly expressed in fetal liver
Secondary accessions: Q96S58 Q9BZC4 Q9NR73 Q9UKP8Alternative splicing: 2 isoforms: Q8IZY2-1 Q8IZY2-2 (Inactive for apoA-I-mediated lipid release)Explore the universe of human proteins at neXtProt for ABCA7: NX_Q8IZY2
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8IZY2
4 DME Specific Peptides for ABCA7 (Q8IZY2)
ABCA7 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_061985.2
ENSEMBL proteins: ENSP00000263094 ENSP00000431473 ENSP00000433545 ENSP00000465322 ENSP00000437311 ENSP00000432031 ENSP00000414062 Reactome Protein details: Q8IZY2
Human Recombinant Protein Products:
Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9): About this table
ABCA7 for ontologies About GeneDecksing
ABCA7 Antibody Products:
Assay Products for ABCA7: |
Protein
Domains /
Families
for ABCA7 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ABCA7 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8IZY2ProtoNet protein and cluster: Q8IZY2 UniProtKB/Swiss-Prot: ABCA7_HUMAN, Q8IZY2Similarity: Belongs to the ABC transporter superfamily. ABCA familySimilarity: Contains 2 ABC transporter domains |
Function
for ABCA7 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ABCA7_HUMAN, Q8IZY2Function: Plays a role in phagocytosis by macrophages of apoptotic cells. Binds APOA1 and may function inapolipoprotein-mediated phospholipid efflux from cells. May also mediate cholesterol efflux. May regulate cellularceramide homeostasis during keratinocytes differentiationInduction: Up-regulated in macrophages upon cholesterol uptake and inversely regulated upon cholesterol deloading fromthe cells (at protein level). Up-regulated in keratinocytes during terminal differentiationEnzyme Numbers (IUBMB): EC 3.6.3.412 EC 3.6.32 EC 2.2.1.12
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ABCA7 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ABCA7
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ABCA7 (NM_019112) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ABCA7 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ABCA7 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ABCA7 |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
ABCA7 for ontologies About GeneDecksing
Animal Models:
Mouse knock-out Abca7tm1Frm for ABCA7
3 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Abca7):
ABCA7 for phenotypes About GeneDecksing
|
Pathways & Interactions
for ABCA7 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | ABC-family proteins mediated transport | | | 2 | Cholesterol and Sphingolipids transport / Recycling to plasma membrane in lung (normal and CF) | | | 3 | SLC-mediated transmembrane transport | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1  GeneGo (Thomson Reuters) Pathway for ABCA7
3 
Reactome Pathways for ABCA7
1 
Kegg Pathway (Kegg details for ABCA7):
ABCA7 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ABCA7
STRING Interaction
Network Preview (showing 5 interactants - click image to see 7)
5/7 Interacting proteins for ABCA7 (ENSP000002630944) via UniProtKB, MINT, STRING, and/or I2D (see all 7)About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table
ABCA7 for ontologies About GeneDecksing
|
Drugs & Compounds
for ABCA7 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
ABCA7 for compounds About GeneDecksing
 Browse Tocris compounds for ABCA7
10/110 HMDB Compounds for ABCA7 (see all 110) About this table
4 Novoseek chemical compound relationships for ABCA7 gene About this table
Search CenterWatch for drugs/clinical trials and news about ABCA7
|
Transcripts
for ABCA7 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ABCA7 gene (2 alternative transcripts): NM_019112.3 NM_033308.1 Unigene Cluster for ABCA7: ATP-binding cassette, sub-family A (ABC1), member 7 Hs.134514 [show with all ESTs]Unigene Representative Sequence: NM_01911217 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000263094(uc002lqw.4) ENST00000530703 ENST00000524850 ENST00000526885(uc010dsa.3)
ENST00000525238 ENST00000531467 ENST00000527496 ENST00000435683(uc010dsb.1)
ENST00000533574 ENST00000530092 ENST00000525073 ENST00000529442 ENST00000532194
ENST00000525939 ENST00000531478 ENST00000524383 ENST00000433129(uc002lqy.3 uc010dsc.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ABCA7 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ABCA7
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ABCA7 (NM_019112) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ABCA7 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ABCA7 |
Additional cDNA sequence: AB055390.1 AF140342.1 AF250238.1 AF328787.1 AK097344.1 AK301108.1 AK310127.1 AK310909.1 AL137481.1 12 DOTS entries: DT.100773838 DT.87046747 DT.100026519 DT.100773843 DT.202026 DT.408328 DT.121417280 DT.97815725 DT.121417268 DT.121417290 DT.121417293 DT.95242964 24/99 AceView cDNA sequences (see all 99): BQ955522 AK097344 AF140342 BU528031 AF328787 BQ959013 BG674537 CD629705 CA314076 CD629708 BQ639122 AI400695 NM_019112 BG775870 H45142 AI668630 AI668632 BF901907 CD629703 CD629707 T87799 AA703073 BU675136 AI831940
GeneLoc Exon Structure
5/11 Alternative Splicing Database (ASD) splice patterns (SP) for ABCA7 (see all 11) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17a | · | 17b | ^ | 18 | ^ | 19 | ^ | 20 | ^ |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 21 | ^ | 22 | ^ | 23 | ^ | 24 | ^ | 25a | · | 25b | ^ | 26 | ^ | 27a | · | 27b | ^ | 28 | ^ | 29 | ^ | 30 | ^ | 31a | · | 31b | ^ | 32 | ^ | 33 | ^ | 34 | ^ | 35a | · | 35b | · | 35c | ^ | 36 | ^ | 37a | · | 37b | ^ | 38 | ^ | 39 | ^ | 40 | ^ |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 41 | ^ | 42 | ^ | 43a | · | 43b | ^ | 44 | ^ | 45a | · | 45b | · | 45c | ^ | 46 | ^ | 47 | ^ | 48 |
|---|
|
| SP1: | | | | | | | | | | | | | - | | - | | | | | | | | |
| SP2: | | | | | | | | | | | | | - | | - | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | - | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for ABCA7
|
Expression
for ABCA7 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ABCA7 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAGGCCGCCT
About this image
See ABCA7 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ABCA7
SOURCE GeneReport for Unigene cluster: Hs.134514
UniProtKB/Swiss-Prot: ABCA7_HUMAN, Q8IZY2Tissue specificity: Expressed in leukocytes (at protein level). Widely expressed. Highly expressed in myelo-lymphatictissues including peripheral leukocytes, thymus, spleen and bone marrow. Isoform 2 is more abundant in lymph node,spleen, thymus and trachea than isoform 1 which is more strongly expressed in brain and bone marrow
SABiosciences Custom PCR Arrays for ABCA7
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ABCA7
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ABCA7 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ABCA7 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ABCA7 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ABCA7 |
Orthologs
for ABCA7 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for ABCA7 gene from 6/19 species (see all 19) About this table
ENSEMBL Gene Tree for ABCA7 (if available)
TreeFam Gene Tree for ABCA7 (if available) |
Paralogs
for ABCA7 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ABCA7 gene
- ABCG12 ABCA12 ABCA102 ABCA132 ABCA32 ABCA82 ABCG42 ABCA122
- ABCG82 ABCA42 ABCG52 ABCA22 ABCA92 ABCA62 ABCA52 ABCG22
12 SIMAP similar genes for ABCA7 using alignment to 7 protein entries: ABCA7_HUMAN (see all proteins):DKFZp434E1030 ABC1 ABC2 ABCA1 DKFZp547P193 DKFZp781N1972
ABCA4 ABCA12 ABCA2 ABCG2 ABCA3 ABCA13
ABCA7 for paralogs About GeneDecksing
|
Genomic Variants
for ABCA7 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ABCA7 (1040102 - 1065571 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for ABCA7
4 CNVs: 4066 2237 5065 30885
1 Indel: 73271
Human Gene Mutation Database (HGMD): ABCA7
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ABCA7 |
|
Disorders
/ Diseases
for ABCA7 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ABCA7 for disorders About GeneDecksing
OMIM gene information: 605414
OMIM disorders: --
14  diseases for ABCA7: About MalaCardsneonatal respiratory failure coronary heart disease tangier disease respiratory failure
sjogren's syndrome neurologic diseases pulmonary disease alzheimer's disease
pharyngitis pneumonia cholesterol schizophrenia
tuberculosis mycobacterium tuberculosis
2 diseases from the University of Copenhagen DISEASES database for ABCA7:Asperger syndrome Tangier disease Genetic Association Database (GAD): ABCA7
Human Genome Epidemiology (HuGE) Navigator: ABCA7 (12 documents)
Export disorders for ABCA7 gene to outside databases
|
Publications
for ABCA7 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ABCA7 gene, integrated from 9 sources (see all 37):
(articles sorted by number of sources associating them with ABCA7) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification of a novel human sterol-sensitive ATP-binding cassette transporter (ABCA7). (PubMed id 10873640)1, 2, 9 Kaminski W.E....Schmitz G. (2000)
- Human ABCA7 supports apolipoprotein-mediated release of cellular cholesterol and phospholipid to generate high density lipoprotein. (PubMed id 14570867)1, 2, 9 Abe-Dohmae S....Yokoyama S. (2004)
- Homozygosity for the 168His variant of the minor histocompatibility antigen HA-1 is associated with reduced risk of primary Sjogren's syndrome. (PubMed id 15593299)1, 4 Harangi M....Schmitz G. (2005)
- Posttranscriptional regulation of human ABCA7 and its function for the apoA-I-dependent lipid release. (PubMed id 14592415)1, 2 Ikeda Y.... Ueda K. (2003)
- ATP-binding cassette transporter A7 (ABCA7) binds apolipoprotein A-I and mediates cellular phospholipid but not cholesterol efflux. (PubMed id 12917409)1, 2 Wang N.... Tall A.R. (2003)
- Adenosine triphosphate binding cassette (ABC) transporters are expressed and regulated during terminal keratinocyte differentiation: a potential role for ABCA7 in epidermal lipid reorganization. (PubMed id 12925201)1, 2 Kielar D.... Schmitz G. (2003)
- Catalog of 605 single-nucleotide polymorphisms (SNPs) among 13 genes encoding human ATP-binding cassette transporters: ABCA4, ABCA7, ABCA8, ABCD1, ABCD3, ABCD4, ABCE1, ABCF1, ABCG1, ABCG2, ABCG4, ABCG5, and ABCG8. (PubMed id 12111378)1, 2 Iida A.... Nakamura Y. (2002)
- Comparative analysis of the promoter structure and genomic organization of the human and mouse ABCA7 gene encoding a novel ABCA transporter. (PubMed id 11435699)1, 2 Broccardo C.... Chimini G. (2001)
- Human ABCA1 contains a large amino-terminal extracellular domain homologous to an epitope of Sjogren's Syndrome. (PubMed id 11355874)1, 2 Tanaka A.R.... Ueda K. (2001)
- Genomic organization of the human cholesterol-responsive ABC transporter ABCA7: tandem linkage with the minor histocompatibility antigen HA-1 gene. (PubMed id 11095984)1, 2 Kaminski W.E.... Schmitz G. (2000)
|
External Searches for ABCA7 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ABCA7 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ABCA7 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ABCA7 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
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| Name | Description |
| PharmGKB entry for ABCA7 | Pharmacogenomics, SNPs, Pathways | | ABCMdb | http://abcmutations.hegelab.org/proteinDetails?uniprot_id=Q8IZY2 |
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About This Section
| Patent Information for ABCA7 gene:
Search GeneIP for patents involving ABCA7
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for ABCA7 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ABCA7 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ABCA7 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ABCA7 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ABCA7 | | OriGene 3'-UTR Clone for ABCA7 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ABCA7 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ABCA7 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for ABCA7 | | OriGene Custom Protein Services for ABCA7 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ABCA7 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ABCA7 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ABCA7 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ABCA7 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ABCA7 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ABCA7 |
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| | | | Search Tocris compounds for ABCA7 |
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 | | | ABCA7 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ABCA7 |
|  |  |  | | | | ThermoFisher Antibody for ABCA7 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ABCA7 |
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