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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ABCA6 Gene

protein-coding   GIFtS: 57
GCID: GC17M067074

ATP-Binding Cassette, Sub-Family A (ABC1), Member 6

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
ATP-Binding Cassette, Sub-Family A (ABC1), Member 61 2     ATP-Binding Cassette Sub-Family A Member 62
EST1550512     EC 2.5.1.198
ABC Transporter ABCA62     EC 3.6.38
ATP-Binding Cassette A62     EC 3.6.3.258

External Ids:    HGNC: 361   Entrez Gene: 234602   Ensembl: ENSG000001542627   OMIM: 6125045   UniProtKB: Q8N1393   

Export aliases for ABCA6 gene to outside databases

Previous GC identifers: GC17M066873 GC17M070035 GC17M067539 GC17M067671 GC17M064586 GC17M062462


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ABCA6 Gene:
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC)
transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are
divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This encoded protein
is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found
exclusively in multicellular eukaryotes. This gene is clustered among 4 other ABC1 family members on 17q24 and
may play a role in macrophage lipid homeostasis. (provided by RefSeq, Jul 2008)

GeneCards Summary for ABCA6 Gene: 
ABCA6 (ATP-binding cassette, sub-family A (ABC1), member 6) is a protein-coding gene. Diseases associated with ABCA6 include tuberculosis, and lung cancer, and among its related super-pathways are ABC-family proteins mediated transport and SLC-mediated transmembrane transport. GO annotations related to this gene include ATPase activity and ATP binding. An important paralog of this gene is ABCG1.

UniProtKB/Swiss-Prot: ABCA6_HUMAN, Q8N139
Function: Probable transporter which may play a role in macrophage lipid homeostasis




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.2  NT_010783.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ABCA6 gene promoter:
         HOXA9B   HOXA9   AML1a   FOXD1   Olf-1   Meis-1b   GATA-1   AREB6   Sox9   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ABCA6 promoter sequence
   Search SABiosciences Chromatin IP Primers for ABCA6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ABCA6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q24.3   Ensembl cytogenetic band:  17q24.3   HGNC cytogenetic band: 17q21

ABCA6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ABCA6 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M067074:  view genomic region     (about GC identifiers)

Start:
67,074,843 bp from pter      End:
67,138,029 bp from pter
Size:
63,187 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ABCA6_HUMAN, Q8N139 (See protein sequence)
Recommended Name: ATP-binding cassette sub-family A member 6  
Size: 1617 amino acids; 184286 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Developmental stage: Expressed in fetal kidney, lung and liver
Sequence caution: Sequence=AAM77557.1; Type=Frameshift; Positions=998, 1000; Sequence=AAM77558.1; Type=Frameshift;
Positions=998, 1000; Sequence=BAC04994.1; Type=Erroneous initiation;
Secondary accessions: Q6NSH9 Q8N856 Q8WWZ6
Alternative splicing: 3 isoforms:  Q8N139-1   Q8N139-2   Q8N139-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ABCA6: NX_Q8N139

Explore proteomics data for ABCA6 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8N139

  • 4/7 DME Specific Peptides for ABCA6 (Q8N139) (see all 7)
     ELKVKET  VLLLDEP  LDEPTTG  GPNGAGKS 

    ABCA6 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ABCA6 Protein Expression
    REFSEQ proteins: NP_525023.2  
    ENSEMBL proteins: 
     ENSP00000284425   ENSP00000466862  
    Reactome Protein details: Q8N139
    Human Recombinant Protein Products for ABCA6: 
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    Cloud-Clone Corp. Proteins for ABCA6 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane IEA--

    ABCA6 for ontologies           About GeneDecksing



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    Cloud-Clone Corp. ELISAs for ABCA6 
    Cloud-Clone Corp. CLIAs for ABCA6


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ABCA: ATP binding cassette transporters / subfamily A

    IUPHAR Guide to PHARMACOLOGY protein family classification: ABCA6 
    ABCA subfamily

    4 InterPro protein domains:
     IPR003439 ABC_transporter-like
     IPR027417 P-loop_NTPase
     IPR003593 AAA+_ATPase
     IPR026082 ABC_A

    Graphical View of Domain Structure for InterPro Entry Q8N139

    ProtoNet protein and cluster: Q8N139

    UniProtKB/Swiss-Prot: ABCA6_HUMAN, Q8N139
    Similarity: Belongs to the ABC transporter superfamily. ABCA family
    Similarity: Contains 2 ABC transporter domains


    ABCA6 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ABCA6_HUMAN, Q8N139
    Function: Probable transporter which may play a role in macrophage lipid homeostasis
    Induction: Up-regulated during monocyte differentiation into macrophages. Down-regulated by cholesterol loading of
    macrophages

         Genatlas biochemistry entry for ABCA6:
    ATP binding cassette superfamily A,member 6

         Enzyme Numbers (IUBMB): EC 2.5.1.192 EC 3.6.32 EC 3.6.3.252

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding ----
    GO:0005524ATP binding IEA--
    GO:0016887ATPase activity IEA--
    GO:0017111nucleoside-triphosphatase activity ----
         
    ABCA6 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ABCA6 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ABCA6 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ABCA6 

    miRNA
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    Inhib. RNA
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    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of ABCA6

    Clone
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ABCA6 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1ABC-family proteins mediated transport
    ABC-family proteins mediated transport0.70
    ABCA transporters in lipid homeostasis0.47
    ABC transporters0.70
    2SLC-mediated transmembrane transport
    Transmembrane transport of small molecules0.50

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3        Reactome Pathways for ABCA6
        ABC-family proteins mediated transport
    ABCA transporters in lipid homeostasis
    Transmembrane transport of small molecules


    1         Kegg Pathway  (Kegg details for ABCA6):
        ABC transporters


    ABCA6 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ABCA6

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for ABCA6 (Q8N1393 ENSP000002844254) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    APOA1P026473, ENSP000002368504I2D: score=1 STRING: ENSP00000236850
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport IEA--

    ABCA6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ABCA6

    1 DrugBank Compound for ABCA6    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Adenosine-5'-Diphosphate-- 20398-34-9target--17139284 17016423 10592235

    Search CenterWatch for drugs/clinical trials and news about ABCA6

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ABCA6 gene (2 alternative transcripts): 
    NM_080284.2  NM_172346.1  

    Unigene Cluster for ABCA6:

    ATP-binding cassette, sub-family A (ABC1), member 6
    Hs.709514  [show with all ESTs]
    Unigene Representative Sequence: BX647672
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000284425(uc002jhw.1 uc002jhy.3) ENST00000446604 ENST00000589482
    ENST00000590311 ENST00000589803 ENST00000592493 ENST00000590645
    miRNA
    Products:
         
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    SwitchGear 3'UTR luciferase reporter plasmidABCA6 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: ABCA6 (NM_080284)
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ABCA6
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ABCA6

    Additional mRNA sequence: 

    AF373290.1 AK097296.1 AK125487.1 AK308431.1 AY028898.1 BC029852.1 BC070125.1 BC125231.1 
    BC125232.1 BX647672.1 

    9 DOTS entries:

    DT.92414827  DT.92041769  DT.102835331  DT.95159621  DT.101981440  DT.75181599  DT.100779501  DT.91715365 
    DT.91735387 

    24/78 AceView cDNA sequences (see all 78):

    AF373290 NM_172346 AK125487 BQ722528 AY028898 NM_080284 BC029852 BF589727 
    CR593055 BX342947 AI695358 CB163196 CD516271 BI489985 AI082697 AI476130 
    AI651541 BI767934 CA946954 AA703500 AA099357 AV763271 BX503185 BQ185780 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ABCA6 expression in normal human tissues (normalized intensities)      ABCA6 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGTGGTCTG
    ABCA6 Expression
    About this image


    ABCA6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Heart (Cardiovascular System)    fully expand to see all 2 entries
             Human Cardiac Myocytes-adult (HCM-a)   
     
     Pancreas (Endocrine System)
             Posterior foregut-like cells ( A scalable, suspension protocol for derivation of...
     
     Endothelium (Cardiovascular System)
             Human umbilical vein endothelial cells (HUVEC)
     
     Fibroblast (Uncategorized)
             Human Cardiac Fibroblasts-adult ventrical (HCF-av)   

    See ABCA6 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ABCA6

    SOURCE GeneReport for Unigene cluster: Hs.709514

    UniProtKB/Swiss-Prot: ABCA6_HUMAN, Q8N139
    Tissue specificity: Widely expressed with higher expression in liver

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ABCA6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ABCA6 gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Abca61 , 5 ATP-binding cassette, sub-family A (ABC1), member 61, 5 76.48(n)1
    67.97(a)1
      11 (73.37 cM)5
    761841  NM_147218.21  NP_671751.21 
     1101768205 
    chicken
    (Gallus gallus)
    Aves --
    --
    45(a)
    1 → many
    18(8181915-8205387)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    42(a)
    1 → many
    GL343630.1(35018-149208)
    zebrafish
    (Danio rerio)
    Actinopterygii abca56
    ATP-binding cassette, sub-family A (ABC1), member ...
    38(a)
    1 → many
    12(40351360-40404440)
    rice
    (Oryza sativa)
    Liliopsida Os.186952 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 71.6(n)    AK122145.1 


    ENSEMBL Gene Tree for ABCA6 (if available)
    TreeFam Gene Tree for ABCA6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ABCA6 gene
    ABCG12  ABCA102  ABCA132  ABCA32  ABCG82  ABCA22  ABCA52  ABCG22  
    ABCA12  ABCA82  ABCG42  ABCA42  ABCA122  ABCA72  ABCG52  ABCA92  
    12 SIMAP similar genes for ABCA6 using alignment to 2 protein entries:     ABCA6_HUMAN (see all proteins):
    ABCA10    ABCA9    DKFZp686F2450    DKFZp686K07118    ABCA8    ABCA11P
    ABC2    ABCA5    ABCA2    DKFZp547P193    ABCG2    DKFZp434E1030

    ABCA6 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for ABCA6
    PGOHUM00000245425


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1307 SNPs in ABCA6 are shown (see all 1307)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs106345351,2
    C--67074351(+) TTTTT-/T/TT  
            
    GACAG
    1 -- ds50011NA 2
    rs1493557561,2
    C--67074529(+) GAGATA/GGAGTT 1 -- ds50010--------
    rs1474667981,2
    --67074595(+) GGCCTC/TCCAAA 1 -- ds50010--------
    rs19903351,2
    C,F,H--67074697(-) ACCAAC/GTACAA 1 -- ds500116Minor allele frequency- G:0.38EA NA NS CSA WA 956
    rs1907466851,2
    --67074811(+) GTTTTC/GTAAAA 1 -- ds50010--------
    rs1172649161,2
    C,F--67075016(+) CTGATG/ATTAAT 1 -- ut311Minor allele frequency- A:0.02NA 120
    rs23022901,2
    C,F,A,H--67075072(-) AAACTT/CATGTT 1 -- ut31 ese316Minor allele frequency- C:0.48MN NS EA NA WA CSA 976
    rs23022891,2
    C,F,A,H--67075294(-) AACATA/GCATTT 1 -- int116Minor allele frequency- G:0.20NS NA EA WA CSA 855
    rs1398506751,2
    C--67075343(+) CCACTC/TGACTT 1 -- int10--------
    rs1454907151,2
    C,F--67075361(+) CCAGTG/ATGCAC 2 /T /I mis12Minor allele frequency- A:0.00NA EU 5865

    HapMap Linkage Disequilibrium report for ABCA6 (67074843 - 67138029 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for ABCA6:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2615334CNV Deletion19546169
    esv2716153CNV Deletion23290073
    esv1450413CNV Deletion17803354
    esv2069389CNV Deletion18987734
    esv2556464CNV Deletion19546169
    nsv2128CNV Insertion18451855
    nsv470598CNV Loss18288195
    nsv908705CNV Loss21882294
    nsv833526CNV Gain17160897

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing ABCA6
    DNA2.0 Custom Variant and Variant Library Synthesis for ABCA6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 612504    OMIM disorders: --

    2 diseases for ABCA6:    About MalaCards
    tuberculosis    lung cancer


    ABCA6 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ABCA6
    Human Genome Epidemiology (HuGE) Navigator: ABCA6 (6 documents)

    Export disorders for ABCA6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ABCA6 gene, integrated from 9 sources (see all 19):
    (articles sorted by number of sources associating them with ABCA6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genetic susceptibility to distinct bladder cancer sub phenotypes. (PubMed id 19692168)1, 4 Guey L.T....Malats N. (2010)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    3. PTEN identified as important risk factor of chronic o bstructive pulmonary disease. (PubMed id 19625176)1, 4 Hosgood H.D....Lan Q. (2009)
    4. Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects. (PubMed id 19343046)1, 4 Saito A....Kamatani N. (2009)
    5. Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China. (PubMed id 19170196)1, 4 Shen M....Lan Q. (2009)
    6. Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway. (PubMed id 18676680)1, 4 Hosgood H.D....Lan Q. (2008)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    9. ABCA6, a novel A subclass ABC transporter. (PubMed id 11478798)1, 2 Kaminski W.E.... Schmitz G. (2001)
    10. ABCG1 (ABC8), the human homolog of the Drosophila white gene, is a regulator of macrophage cholesterol and phospholipid transport. (PubMed id 10639163)1, 2 Klucken J.... Schmitz G. (2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23460 HGNC: 36 AceView: ABCA6 Ensembl:ENSG00000154262 euGenes: HUgn23460
    ECgene: ABCA6 Kegg: 23460 H-InvDB: ABCA6

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ABCA6 Pharmacogenomics, SNPs, Pathways
    ABCMdbhttp://abcmutations.hegelab.org/proteinDetails?uniprot_id=Q8N139

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ABCA6 gene:
    Search GeneIP for patents involving ABCA6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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