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ABCA3 Gene

protein-coding GIFtS: 63

GC16M002265

ATP-binding cassette, sub-family A (ABC1), member 3
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: ABC3)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
ABC-C ^¹, ²
ABC3 ^², ³, ⁵
EST111653 ^¹, ²
LBM180 ^¹, ²
MGC166979 ^²
MGC72201 ^²
SMDP3 ^², ⁵

Descriptions
ABC transporter 3 ^²
ABC-C transporter ^³
ATP-binding cassette 3 ^³
ATP-binding cassette transporter 3 ^³
ATP-binding cassette, sub-family A (ABC1), member 3 ^²
ATP-binding cassette, sub-family A member 3 ^²
ATP-binding cassette, sub-family A, member 3 ^¹

External Ids
HGNC: 33¹
Entrez Gene: 21²
UniProtKB: Q99758³
Ensembl: ENSG00000167972⁷

Search outside databases for aliases for ABCA3 gene

Previous GC identifers: GC16P002406 GC16M002351

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for ABCA3:

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding

cassette (ABC) transporters. ABC proteins transport various molecules across extra- and

intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP,

MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1

subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. The

full transporter encoded by this gene may be involved in development of resistance to xenobiotics

and engulfment during programmed cell death. [provided by RefSeq]

UniProtKB/Swiss-Prot: ABCA3_HUMAN, Q99758

Function: Plays an important role in the formation of pulmonary surfactant, probably by

transporting lipids such as cholesterol

Gene Wiki entry for ABCA3

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ABCA3 gene

Entrez Gene cytogenetic band: 16p13.3 Ensembl cytogenetic band: 16p13.3 HGNC cytogenetic band: 16p13.3

ABCA3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 16 GeneLoc Exon Structure

GeneLoc location for GC16M002265: (about GC identifiers)

Start:	2,265,880 bp from pter
End:	2,330,748 bp from pter
Size:	64,869 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000016.8 NT_037887.4

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: ABCA3_HUMAN, Q99758 (See protein sequence)

Recommended Name: ATP-binding cassette sub-family A member 3

Size: 1704 amino acids; 191362 Da

Subcellular location: Membrane; Multi-pass membrane protein (Potential)

Secondary accessions: Q54A95 Q92473

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_001080.2

ENSEMBL proteins:

ENSP00000301732 ENSP00000371818

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (P180 Lamellar Body Protein)
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

4 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005624	membrane fraction	TAS	9027511
GO:0005886	plasma membrane	IDA	11718719
GO:0016021	integral to membrane	TAS	9027511
GO:0042599	lamellar body	IDA	11718719

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Antibodies for ABCA3:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for ABCA3
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (P180 Lamellar Body Protein), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for ABCA3

Assays for ABCA3:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q99758

ProtoNet protein and cluster: Q99758

UniProtKB/Swiss-Prot: ABCA3_HUMAN, Q99758

Domain: Multifunctional polypeptide with two homologous halves, each containing an hydrophobic

membrane-anchoring domain and an ATP binding cassette (ABC) domain (By similarity)

Similarity: Belongs to the ABC transporter family. ABCA subfamily

Similarity: Contains 2 ABC transporter domains

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ABCA3)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ABCA3)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001089

Applied Biosystems Silencer® siRNAs for ABCA3

Sigma-Aldrich siRNA and siRNA Panels for ABCA3

Sigma-Aldrich shRNA for ABCA3

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_001089
Myc/DDK tagged cDNA clone in CMV expression vector: NM_001089
untagged cDNA clone in CMV expression vector: NM_001089

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001089

UniProtKB/Swiss-Prot: ABCA3_HUMAN, Q99758

Function: Plays an important role in the formation of pulmonary surfactant, probably by

transporting lipids such as cholesterol

Genatlas biochemistry entry for ABCA3:

ATP binding cassette superfamily,subfamily A,member 3,involved in resistance to xenobiotics,mouse

ABC2 (mu ABC2) homolog,highly expressed in lung,brain,heart,pancreas

6 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Abca3):

	behavior/neurological	homeostasis/metabolism	lethality-prenatal/perinatal	renal/urinary system
respiratory system

5 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0005215	transporter activity	TAS	9027511
GO:0005524	ATP binding	TAS	9027511
GO:0016887	ATPase activity	IEA	--
GO:0042626	ATPase activity, coupled to transmembrane movement of substances	TAS	9027511

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for ABCA3

5/9 Interacting proteins for ABCA3 (ENSP00000371818³) via UniProtKB, MINT, and/or STRING (see all 9 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
NKX2-1	ENSP00000353918³	STRING (score=.946)
ABCA9	ENSP00000342216³	STRING (score=.916)
SFTPB	ENSP00000345161³	STRING (score=.849)
STAT3	ENSP00000264657³	STRING (score=.845)
LEPREL2	ENSP00000290510³	STRING (score=.842)

About this table

2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006810	transport	IDA	15531465
GO:0042493	response to drug	TAS	8706931

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for ABCA3
2 Novoseek chemical compound relationships for ABCA3 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
atp	28.06	1	15465012 (1)
lipid	0.00	1	16847209 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ABCA3)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ABCA3)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001089

Sigma-Aldrich siRNA and siRNA Panels for ABCA3

Sigma-Aldrich shRNA for ABCA3

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001089

REFSEQ mRNAs for ABCA3 gene:

NM_001089.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001089

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001089
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001089
                                 untagged cDNA clone in CMV expression vector: NM_001089

Additional cDNA sequence:

AB070929.1 AB210044.1 AK310864.1 BC020724.1 BC035752.1 BC062779.1 BC140895.1 BC146866.1

BC151840.1 U66675.1 U78735.1 X97187.1

9 DOTS entries:

DT.415038 DT.97822342 DT.97797548 DT.95163281 DT.97846373 DT.120688009 DT.95163280 DT.91743399

DT.95163277

24/35 AceView cDNA sequences (see all 35 ):

BE669619 X97187 AB070929 BE669421 BE251915 BC035752 NM_001089 BC020724

BC062779 U78735 AA351351 AW450470 BX372615 BQ328862 BX101771 BE671452

BM990801 BU856049 BF090334 BF091460 AW295642 BF923714 AW900257 T05334

highest scoring ESTs for ABCA3:

U78735 AA351351 AB070929 AW296862 AW450470 BE251915 BF851463 BF923714 NM_001089 X97187

Unigene Cluster for ABCA3:

ATP-binding cassette, sub-family A (ABC1), member 3

Hs.26630 [show with all ESTs]

Unigene Representative Sequence: NM_001089

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for ABCA3

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5	^	6a	·	6b	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14	^	15	^	16	^	17	^	18	^	19	^	20	^	21	^	22	^	23	^	24	^
SP1:															-
SP2:															-								-
SP3:
SP4:

ExUns:	25a	·	25b	^	26	^	27a	·	27b	^	28	^	29	^	30	^	31	^	32
SP1:	-
SP2:	-
SP3:
SP4:

About this scheme

ECgene alternative splicing isoforms for ABCA3

2 Ensembl transcripts including schematic representations:

ENST00000301732 ENST00000382381

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

ABCA3 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ABCA3

¹ / ² / ³

3 probe-sets matching ABCA3 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
35183_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	U78735	1.00	0.90	0.95	1
204343_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_001089	0.60	1.00	0.82	1
204343_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks ABCA3 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TGTCAAAAAA

SOURCE GeneReport for Unigene cluster: Hs.26630
Expression variation in blood from EXPOLDB for ABCA3
UniProtKB/Swiss-Prot: ABCA3_HUMAN, Q99758
Tissue specificity: Highly expressed in lung, followed by brain, pancreas, skeletal muscle and
heart. Weakly expressed in placenta, kidney and liver. Also expressed in medullary thyroid
carcinoma cells (MTC) and in C-cell carcinoma

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ABCA3 gene from 5/12 species (see all 12 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ABCA3¹	--	ATP-binding cassette, sub-family A (ABC1), member 3	86.54(n) 88.07(a)	479879 XM_537004.2 XP_537004.2
chimpanzee (Pan troglodytes)	ABCA3¹	--	ATP-binding cassette, sub-family A (ABC1), member 3	99.24(n) 99.59(a)	453833 XM_510744.2 XP_510744.2
cow (Bos taurus)	ABCA3¹	--	ATP-binding cassette, sub-family A (ABC1), member 3	87.55(n) 89.14(a)	505787 XM_582132.3 XP_582132.3
rat (Rattus norvegicus)	Abca3¹	--	ATP-binding cassette, sub-family A (ABC1), member 3	84.69(n) 88.19(a)	302973 XM_220219.4 XP_220219.4
mouse (Mus musculus)	Abca3^{1, 5}	17⁵	ATP-binding cassette, sub-family A (ABC1), member 3^{1, 5}	84.49(n)¹ 88.09(a)¹	27410¹ NM_001039581.1¹ NP_001034670.1¹ AA154997⁵ AF213394⁵ (see all 24)

About this table Species with no ortholog for ABCA3

ENSEMBL Gene Tree for ABCA3

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/402 NCBI SNPs in ABCA3 are shown (see all 402 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 106)

AB	SNP ID	Valid	Chr 16 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs323048^1,2	A,C,F	2318664(-)	`GGACTC/GCTCTC`	1	--	ut5¹ ese³		6	EA NA MN NS	338
	rs4146825^1,2	C,F,H	2319812(-)	`GATGTC/TCTGCG`	1	--	ut5¹ ese³		10	EU EA WA NS	928
	rs17135880^1,2	C,F,H	2318457(+)	`AACCTG/CCTAGA`	1	--	ut5¹		13	NA EU EA WA NS	996
	rs323049^1,2	C,F	2318597(-)	`CCATCG/ACCTTC`	1	--	ut5¹		6	EA NA MN NS	338
	rs13332760^1,2	H	2279621(+)	`CCCGAC/ACCTGT`	1	F/V	mis¹		4	EU EA WA	390
	rs149532^1,2	A,C,F,H	2271431(-)	`CCCAGC/TCCGGA`	1	S/S	syn¹ ese³		11	MN NA EU EA WA NS	872
	rs323043^1,2	C,F,H	2288529(-)	`CCCCCC/GACCAG`	1	P/P	syn¹ ese³ trp³		8	MN EU EA WA NS	744
	rs13332514^1,2	C,F	2307337(+)	`ATGGCG/AAAGCA`	1	F/F	syn¹ ese³		3	NA NS	164
--	rs45620539^1,2	F	2285666(-)	`CACCAC/TGTGCC`	1	H/H	syn¹		2	NS	92
--	rs45480502^1,2	F	2309775(-)	`CATGCC/TGATGC`	1	A/A	syn¹		2	NS	94

About this table

HapMap Linkage Disequilibrium images for ABCA3 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 601615 disorders: 610921

UniProtKB/Swiss-Prot: ABCA3_HUMAN, Q99758

Defects in ABCA3 are the cause of pulmonary surfactant metabolism dysfunction type 3

(SMDP3) [MIM:610921]; also called pulmonary alveolar proteinosis due to ABCA3 deficiency. Inborn

errors of pulmonary surfactant metabolism are genetically heterogeneous disorders resulting in

severe respiratory insufficiency or failure in full-term neonates or infants. These disorders are

associated with various pathologic entities, including pulmonary alveolar proteinosis (PAP),

desquamative interstitial pneumonitis (DIP), or cellular non-specific interstitial pneumonitis

(NSIP)

1 Novoseek disease relationship for ABCA3 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
lung diseases	35.40	3	16982851 (1), 15985750 (1), 17127271 (1)

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Human Gene Mutation Database: ABCA3
Genetic Association Database: ABCA3
Human Genome Epidemiology Navigator: ABCA3 (4 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

New System for Classifying Infant Lung Disease Developed

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/37 PubMed articles for ABCA3 gene (see all 37 ):

Primary structure of a novel ABC transporter with a chromosomal localization on the band encoding the multidrug resistance-associated protein. (PubMed id 8706931)^{1, 2, 3, 4} Klugbauer N. and Hofmann F. (1996)
ABCA3 gene mutations in newborns with fatal surfactant deficiency. (PubMed id 15044640)^{3, 4, 6} Shulenin S.... Dean M. (2004)
ABCA3 is a lamellar body membrane protein in human lung alveolar type II cells. (PubMed id 11718719)^{1, 3, 4} Yamano G.... Inagaki N. (2001)
The cloning of a human ABC gene (ABC3) mapping to chromosome 16p13.3. (PubMed id 9027511)^{1, 3, 4} Connors T.D....Burn T.C. (1997)
ABCA3 mutations associated with pediatric interstitial lung disease. (PubMed id 15976379)^{3, 6} Bullard J.E....Nogee L.M. (2005)
Human ABCA3, a product of a responsible gene for abca3 for fatal surfactant deficiency in newborns, exhibits unique ATP hydrolysis activity and generates intracellular multilamellar vesicles. (PubMed id 15465012)^{1, 3} Nagata K....Ueda K. (2004)
Population and disease-based prevalence of the common mutations associated with surfactant deficiency. (PubMed id 18317237)^{1, 3} Garmany T.H....Hamvas A. (2008)
ABCA3 Deficiency: an unusual cause of respiratory distress in the newborn. (PubMed id 19252731)^{1, 3} Anandarajan M....Tubman R. (2009)
Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects. (PubMed id 19343046)³ Saito A....Kamatani N. (2009)
Cerebropulmonary dysgenetic syndrome. (PubMed id 18603241)³ Shanklin D.R....Baldwin H.S. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 21	HGNC: 33	AceView: ABCA3	Ensembl:ENSG00000167972	euGenes: HUgn21
ECgene: ABCA3	H-InvDB: ABCA3

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
GeneReviews	http://www.genetests.org/query?gene=ABCA3
SeattleSNPs	http://pga.gs.washington.edu/data/abca3/

Licensable Technologies for ABCA3
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for ABCA3:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ABCA3-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ABCA3		Antibodies for ABCA3
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for ABCA3		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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	Custom Service for Rabbit Pab from Full-length Protein

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	Recombinant Proteins (P180 Lamellar Body Protein)
	Antibodies (P180 Lamellar Body Protein)

Search OriGene for ABCA3

Search Tocris compounds for ABCA3

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Search Novus for antibodies for ABCA3

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ABCA3 Gene

protein-coding GIFtS: 63

Aliases &
Descriptions
for ABCA3

Summaries
for ABCA3

Genomic Location
for ABCA3

Proteins
for ABCA3

Protein Domains/
Families
for ABCA3

Gene Function
for ABCA3

Pathways & Interactions
for ABCA3

Drugs & Compounds
for ABCA3

Transcripts
for ABCA3

Expression
for ABCA3

Orthologs
for ABCA3

Paralogs
for ABCA3

SNPs/Variants
for ABCA3

Disorders & Mutations
for ABCA3

Medical News
for ABCA3

Publications
for ABCA3

Search for ABCA3

Genome Databases showing ABCA3

Other Databases showing ABCA3

Specialized Databases showing ABCA3

Licensable Technologies
for ABCA3

Services
for ABCA3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ABCA3 Gene

protein-coding GIFtS: 63

Aliases & Descriptionsfor ABCA3

Summariesfor ABCA3

Genomic Locationfor ABCA3

Proteinsfor ABCA3

Protein Domains/Familiesfor ABCA3

Gene Functionfor ABCA3

Pathways & Interactionsfor ABCA3

Drugs & Compoundsfor ABCA3

Transcriptsfor ABCA3

Expression for ABCA3

Orthologsfor ABCA3

Paralogsfor ABCA3

SNPs/Variantsfor ABCA3

Disorders & Mutationsfor ABCA3

Medical Newsfor ABCA3

Publicationsfor ABCA3

Search for ABCA3

Genome Databases showing ABCA3

Other Databases showing ABCA3

Specialized Databases showing ABCA3

Licensable Technologiesfor ABCA3

Servicesfor ABCA3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ABCA3

Summaries
for ABCA3

Genomic Location
for ABCA3

Proteins
for ABCA3

Protein Domains/
Families
for ABCA3

Gene Function
for ABCA3

Pathways & Interactions
for ABCA3

Drugs & Compounds
for ABCA3

Transcripts
for ABCA3

Expression
for ABCA3

Orthologs
for ABCA3

Paralogs
for ABCA3

SNPs/Variants
for ABCA3

Disorders & Mutations
for ABCA3

Medical News
for ABCA3

Publications
for ABCA3

Licensable Technologies
for ABCA3

Services
for ABCA3