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ABCA2 Gene

protein-coding GIFtS: 62

GC09M139021

ATP-binding cassette, sub-family A (ABC1), member 2
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: ABC2)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
ABC2 ^², ³, ⁵
KIAA1062 ^³
MGC129761 ^²
OTTHUMP00000064733 ^²

Descriptions
ATP-binding cassette 2 ^³
ATP-binding cassette transporter 2 ^³
ATP-binding cassette, sub-family A (ABC1), member 2 ^²
ATP-binding cassette, sub-family A, member 2 ^²

External Ids
HGNC: 32¹
Entrez Gene: 20²
UniProtKB: Q9BZC7³
Ensembl: ENSG00000107331⁷

Search outside databases for aliases for ABCA2 gene

Previous GC identifers: GC09P131061 GC09M131591 GC09M133342 GC09M135258 GC09M137177

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for ABCA2:

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding

cassette (ABC) transporters. ABC proteins transport various molecules across extra- and

intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP,

MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1

subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes.

This protein is highly expressed in brain tissue and may play a role in macrophage lipid

metabolism and neural development. Two transcript variants encoding different isoforms have been

found for this gene. [provided by RefSeq]

UniProtKB/Swiss-Prot: ABCA2_HUMAN, Q9BZC7

Function: Probable transporter, its natural substrate has not been found yet. May have a role in

macrophage lipid metabolism and neural development

Gene Wiki entry for ABCA2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ABCA2 gene

Entrez Gene cytogenetic band: 9q34 Ensembl cytogenetic band: 9q34.3 HGNC cytogenetic band: 9q34

ABCA2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 9 GeneLoc Exon Structure

GeneLoc location for GC09M139021: (about GC identifiers)

Start:	139,021,507 bp from pter
End:	139,043,195 bp from pter
Size:	21,689 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000009.10 NT_024000.16

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: ABCA2_HUMAN, Q9BZC7 (See protein sequence)

Recommended Name: ATP-binding cassette sub-family A member 2

Size: 2435 amino acids; 269873 Da

Subcellular location: Membrane; Multi-pass membrane protein (Potential)

Secondary accessions: A6NED5 Q5SPY5 Q5W9G5 Q76MW7

Alternative splicing: 2 isoforms: Q9BZC7-1 Q9BZC7-2

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_001597.2 NP_997698.1

ENSEMBL proteins:

ENSP00000347205 ENSP00000360666 ENSP00000265662 ENSP00000344155 ENSP00000381268 ENSP00000381265

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (ABCA2)
	Human Recombinant Proteins from Abnova (ABCA2)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5/6 Gene Ontology (GO) cellular component terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005765	lysosomal membrane	IDA	11309290
GO:0005815	microtubule organizing center	ISS	--
GO:0016020	membrane	IEA	--
GO:0016021	integral to membrane	RCA	11309290 12363033
GO:0016023	cytoplasmic membrane-bounded vesicle	ISS	--

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Antibodies for ABCA2:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (ABCA2), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Novus Biologicals Antibody for ABCA2

Assays for ABCA2:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q9BZC7

ProtoNet protein and cluster: Q9BZC7

UniProtKB/Swiss-Prot: ABCA2_HUMAN, Q9BZC7

Similarity: Belongs to the ABC transporter family. ABCA subfamily

Similarity: Contains 2 ABC transporter domains

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ABCA2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ABCA2)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_212533

Applied Biosystems Silencer® siRNAs for ABCA2

Sigma-Aldrich siRNA and siRNA Panels for ABCA2

Sigma-Aldrich shRNA for ABCA2

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001606
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001606
untagged cDNA clones in CMV expression vector (see all 3): NM_001606

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_212533

UniProtKB/Swiss-Prot: ABCA2_HUMAN, Q9BZC7

Function: Probable transporter, its natural substrate has not been found yet. May have a role in

macrophage lipid metabolism and neural development

Genatlas biochemistry entry for ABCA2:

ATP binding cassette superfamily,subfamily A,member 2,mouse ABC2 homolog,widely expressed

7 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Abca2):

behavior/neurological	growth/size	hearing/vestibular/ear	homeostasis/metabolism	life span-post-weaning/aging
nervous system	reproductive system

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	RCA	12363033
GO:0005524	ATP binding	ISS	--
GO:0016887	ATPase activity	IDA	15999530
GO:0042626	ATPase activity, coupled to transmembrane movement of substances	NAS	7766993

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

1 Sigma-Aldrich "Your Favorite Gene" Pathway for ABCA2 (Your Favorite Gene powered by Ingenuity)

Purine Metabolism

GeneDecks ABCA2 for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for ABCA2

5/14 Interacting proteins for ABCA2 (ENSP00000347205³) via UniProtKB, MINT, and/or STRING (see all 14 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ABCB10	ENSP00000355637³	STRING (score=.961)
ABCD2	ENSP00000310688³	STRING (score=.952)
LDLR	ENSP00000252444³	STRING (score=.931)
ABCA7	ENSP00000263094³	STRING (score=.92)
ABCB9	ENSP00000280560³	STRING (score=.91)

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5/7 Gene Ontology (GO) biological process terms (links to tree view) (see all 7 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006357	regulation of transcription from RNA polymerase II promoter	IDA	15238223
GO:0006629	lipid metabolic process	NAS	11178988
GO:0006810	transport	NAS	7766993 11178988
GO:0032383	regulation of intracellular cholesterol transport	IMP	15238223
GO:0042493	response to drug	TAS	12363033

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for ABCA2
7 Novoseek chemical compound relationships for ABCA2 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
abc2	98.16	22	10970803 (7), 9537224 (5), 11270397 (2), 11804192 (1) (see all 6)
8-azido-atp	80.70	1	10970803 (1)
aaph	68.56	3	17029687 (1), 17266523 (1)
atp	36.53	5	15238223 (2), 12560508 (1), 15999530 (1), 10970803 (1)
cholesterol	30.56	8	17029687 (3), 15238223 (2), 17266523 (2)
estradiol	24.14	2	17029687 (1), 17266523 (1)
lipid	0.00	1	16752360 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ABCA2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ABCA2)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_212533

Sigma-Aldrich siRNA and siRNA Panels for ABCA2

Sigma-Aldrich shRNA for ABCA2

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001606 NM_212533

REFSEQ mRNAs for ABCA2 gene (2 alternative transcripts):

NM_001606.4 NM_212533.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001606 NM_212533

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001606
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001606
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_001606

Additional cDNA sequence:

AB028985.2 AB177854.1 AF178941.1 AF327657.1 AK295489.1 AK308738.1 AL162060.1 AL833967.1

BC008755.1 BC029282.1 BC064542.1 BC090860.1 BC109244.1 BC144588.1 BC144589.1 U18236.1

18 DOTS entries:

DT.92441449 DT.100760652 DT.313167 DT.91698218 DT.95259311 DT.100036596 DT.121190633 DT.100834574

DT.100766847 DT.92441447 DT.97855540 DT.100732609 DT.102828477 DT.121190624 DT.121190474 DT.95244735

DT.95259318 DT.97782175

24/308 AceView cDNA sequences (see all 308 ):

AI174196 BI756105 BM314649 BF516223 AF327657 BQ962877 BM820930 CB069459

CK821360 BM479039 CA454711 CA942248 AL833967 BI755960 BG315241 BE273611

BM709196 NM_001606 BF851321 BM848734 AB028985 CA454786 AA351626 BI039809

highest scoring ESTs for ABCA2:

AB028985 BM921499 BM921500 AA324817 AA351625 AA351626 AA702968 AA725355 AA748768 AA772600

Unigene Cluster for ABCA2:

ATP-binding cassette, sub-family A (ABC1), member 2

Hs.421202 [show with all ESTs]

Unigene Representative Sequence: NM_001606

GeneLoc Exon Structure

5/19 Alternative Splicing Database (ASD) splice patterns (SP) for ABCA2 (see all 19 )

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9a	·	9b	^	10a	·	10b	^	11	^	12a	·	12b	^	13a	·	13b	^	14	^	15	^	16	^	17a	·	17b	^	18	^	19	^	20	^	21	^
SP1:
SP2:					-
SP3:
SP4:
SP5:

ExUns:	22	^	23	^	24	^	25	^	26	^	27a	·	27b	^	28a	·	28b	^	29	^	30	^	31a	·	31b	·	31c	^	32a	·	32b	^	33a	·	33b	·	33c	^	34a	·	34b	^	35	^	36	^	37	^	38a	·	38b	^
SP1:																	-												-
SP2:
SP3:																													-				-
SP4:																													-				-
SP5:																																	-

ExUns:	39a	·	39b	·	39c	^	40a	·	40b	^	41a	·	41b	^	42a	·	42b	·	42c	^	43a	·	43b	^	44	^	45	^	46	^	47a	·	47b	^	48	^	49	^	50	^	51a	·	51b	·	51c
SP1:
SP2:
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for ABCA2

6 Ensembl transcripts including schematic representations:

ENST00000355090 ENST00000371605 ENST00000265662 ENST00000341511 ENST00000398210 ENST00000398207

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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ABCA2 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ABCA2

¹ / ² / ³

8 probe-sets matching ABCA2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
71904_at²^{, 3}	U95-E	1	1.00	1.00	0.34	1.05	AA748768	0.60	1.00	0.82	1
38313_at²^{, 3}	U95-A	1	1.00	1.00	0.90	1.10	AB028985	0.80	1.00	0.91	1
918_at²^{, 3}	U95-A	1	1.00	1.00	0.95	0.87	HG4724-HT5166	0.20	1.00	0.72	1
31725_s_at²^{, 3}	U95-A	1	1.00	1.00	-0.48	0.08	U18235	0.60	1.00	0.82	1
210100_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AF327657	0.60	1.00	0.82	1
212772_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AL162060	0.60	1.00	0.82	1
210100_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
212772_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks ABCA2 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CCCTGCGGTC

SOURCE GeneReport for Unigene cluster: Hs.421202
Expression variation in blood from EXPOLDB for ABCA2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for ABCA2 gene from 4 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ABCA2¹	--	ATP-binding cassette, sub-family A (ABC1), member 2	87.66(n) 92.07(a)	480669 XM_537788.2 XP_537788.2
rat (Rattus norvegicus)	Abca2¹	--	ATP-binding cassette, sub-family A (ABC1), member 2	86.81(n) 92.97(a)	79248 NM_024396.1 NP_077372.1
mouse (Mus musculus)	Abca2^{1, 5}	2 (12.60 cM)⁵	ATP-binding cassette, sub-family A (ABC1), member 2^{1, 5}	86.62(n)¹ 93.46(a)¹	11305¹ NM_007379.2¹ NP_031405.2¹ AI413825⁵ AI451433⁵ (see all 14)
fruit fly (Drosophila melanogaster)	BG:DS00797.5³	34D1	ATP-binding cassette (ABC) transporter	32(a)	--

About this table Species with no ortholog for ABCA2

ENSEMBL Gene Tree for ABCA2

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for ABCA2 gene

ABCA12² ABCA13²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/94 NCBI SNPs in ABCA2 are shown (see all 94 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 47)

AB	SNP ID	Valid	Chr 9 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
--	rs7036668^1,2	A,C,F,H	139021712(+)	`CCCGCG/AGGACA`	2	--	ut3¹ ese³		4	EU EA WA	412
	rs2090625^1,2	C,F,H	139032319(+)	`CACAAA/CAGTGT`	2	F/V	mis¹ ese³		8	EU EA WA	822
	rs908828^1,2	A,C,H	139033060(-)	`CTTCCC/ACGACG`	2	H/P	mis¹ ese³		5	MN EU EA WA	602
	rs4335222^1,2	C,F	139021802(-)	`AGCGGG/TCTGTG`	2	--	ut3¹ ese³		2	NA	182
	rs2271862^1,2	A,C,F,H	139026180(+)	`TGCAGA/GTGCTT`	2	H/H	syn¹		9	EA EU WA	2296
	rs12348881^1,2	A,C,F,H	139031804(+)	`TAGACT/GGCCAG`	2	A/A	syn¹		4	EU EA WA	418
	rs7048567^1,2	A,C,F,H	139023858(+)	`AGGTCG/AAGGAT`	2	L/L	syn¹		4	EU EA WA	418
	rs908832^1,2	C,F	139032305(+)	`ACCACG/ATCGTG`	2	D/D	syn¹		1	MN	184
	rs2271864^1,2	H	139029249(+)	`AGCTCC/TGTGCT`	2	T/T	syn¹ ese³		2	EA EU	1616
	rs35099111^1,2	F	139025716(+)	`GTGGCC/AACGGT`	2	V/V	syn¹		2	NA	182

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HapMap Linkage Disequilibrium images for ABCA2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 600047

6 Novoseek disease relationships for ABCA2 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
neuroma acoustic	51.36	3	15850583 (2), 17266523 (1)
ovarian carcinoma	51.29	3	9537224 (1), 17029687 (1), 17266523 (1)
senile plaques	45.08	4	17029687 (1), 17266523 (1)
atherosclerosis	13.52	2	17029687 (1), 17266523 (1)
alzheimers disease	12.04	3	16752360 (2), 17029687 (1)
cancer	0.00	2	17029687 (1), 17266523 (1)

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Human Genome Epidemiology Navigator: ABCA2 (4 documents)

(Possibly Related Articles in Doctor's Guide)
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(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/35 PubMed articles for ABCA2 gene (see all 35 ):

Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{3, 4} Olsen J.V....Mann M. (2006)
Complete coding sequence, promoter region, and genomic structure of the human ABCA2 gene and evidence for sterol-dependent regulation in macrophages. (PubMed id 11178988)^{3, 4} Kaminski W.E.... Schmitz G. (2001)
Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10470851)^{3, 4} Kikuno R....Ohara O. (1999)
Cloning of two novel ABC transporters mapping on human chromosome 9. (PubMed id 8088782)^{2, 3} Luciani M.F....Chimini G. (1994)
Cloning and characterization of human adenosine 5'-triphosphate- binding cassette, sub-family A, transporter 2 (ABCA2). (PubMed id 11309290)^{1, 3} Vulevic B.... Tew K.D. (2001)
Expression of ABCA2 protein in human vestibular schwannoma and peripheral nerve. (PubMed id 15850583)^{1, 3} Wang Y....Inagaki N. (2005)
Cloning, characterization and tissue distribution of the rat ATP- binding cassette (ABC) transporter ABC2/ABCA2. (PubMed id 10970803)^{1, 3} Zhao L.-X.... Inagaki N. (2000)
Reciprocal regulation of expression of the human adenosine 5'-triphosphate binding cassette, sub-family A, transporter 2 (ABCA2) promoter by the early growth response-1 (EGR-1) and Sp-family transcription factors. (PubMed id 12560508)^{1, 3} Davis W....Tew K.D. (2003)
Ethnicity-dependent genetic association of ABCA2 with sporadic Alzheimer's disease. (PubMed id 16752360)^{1, 3} Wollmer M.A....Papassotiropoulos A. (2006)
Human ATP-binding cassette transporter-2 (ABCA2) positively regulates low-density lipoprotein receptor expression and negatively regulates cholesterol esterification in Chinese hamster ovary cells. (PubMed id 15238223)^{1, 3} Davis W....Tew K.D. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 20	HGNC: 32	AceView: ABCA2	Ensembl:ENSG00000107331	euGenes: HUgn20
ECgene: ABCA2	H-InvDB: ABCA2

(According to HUGE)
About This Section

HUGE: KIAA1062

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for ABCA2
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for ABCA2:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ABCA2-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ABCA2		Browse antibodies at Sigma-Aldrich
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	Lentivirus-delivered shRNAs for ABCA2		Browse small molecules at Sigma-Aldrich
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Antibodies for ABCA2

GeneCards Homepage - Last full update: 1 Jul 2009 Incremental update: 13 Oct 2009

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
ABCA2 Gene at Home site.
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ABCA2 Gene

protein-coding GIFtS: 62

Aliases &
Descriptions
for ABCA2

Summaries
for ABCA2

Genomic Location
for ABCA2

Proteins
for ABCA2

Protein Domains/
Families
for ABCA2

Gene Function
for ABCA2

Pathways & Interactions
for ABCA2

Drugs & Compounds
for ABCA2

Transcripts
for ABCA2

Expression
for ABCA2

Orthologs
for ABCA2

Paralogs
for ABCA2

SNPs/Variants
for ABCA2

Disorders & Mutations
for ABCA2

Medical News
for ABCA2

Publications
for ABCA2

Search for ABCA2

Genome Databases showing ABCA2

Other Databases showing ABCA2

Specialized Databases showing ABCA2

Licensable Technologies
for ABCA2

Services
for ABCA2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ABCA2 Gene

protein-coding GIFtS: 62

Aliases & Descriptionsfor ABCA2

Summariesfor ABCA2

Genomic Locationfor ABCA2

Proteinsfor ABCA2

Protein Domains/Familiesfor ABCA2

Gene Functionfor ABCA2

Pathways & Interactionsfor ABCA2

Drugs & Compoundsfor ABCA2

Transcriptsfor ABCA2

Expression for ABCA2

Orthologsfor ABCA2

Paralogsfor ABCA2

SNPs/Variantsfor ABCA2

Disorders & Mutationsfor ABCA2

Medical Newsfor ABCA2

Publicationsfor ABCA2

Search for ABCA2

Genome Databases showing ABCA2

Other Databases showing ABCA2

Specialized Databases showing ABCA2

Licensable Technologiesfor ABCA2

Servicesfor ABCA2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ABCA2

Summaries
for ABCA2

Genomic Location
for ABCA2

Proteins
for ABCA2

Protein Domains/
Families
for ABCA2

Gene Function
for ABCA2

Pathways & Interactions
for ABCA2

Drugs & Compounds
for ABCA2

Transcripts
for ABCA2

Expression
for ABCA2

Orthologs
for ABCA2

Paralogs
for ABCA2

SNPs/Variants
for ABCA2

Disorders & Mutations
for ABCA2

Medical News
for ABCA2

Publications
for ABCA2

Licensable Technologies
for ABCA2

Services
for ABCA2