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ABCA12 Gene

protein-coding GIFtS: 62

GC02M215504

ATP-binding cassette, sub-family A (ABC1), member 12
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
ABC12 ^³
DKFZP434G232 ^¹
DKFZp434G232 ^²
FLJ41584 ^²
ICR2B ^¹, ², ⁵
LI2 ^¹, ², ⁵

Descriptions
ATP-binding cassette 12 ^³
ATP-binding cassette transporter 12 ^³
ATP-binding cassette, sub-family A (ABC1), member 12 ^²
ATP-binding cassette, sub-family A, member 12 ^²
ichthyosis congenita II, lamellar ichthyosis B ^²

External Ids
HGNC: 14637¹
Entrez Gene: 26154²
UniProtKB: Q86UK0³
Ensembl: ENSG00000144452⁷

Search outside databases for aliases for ABCA12 gene

Previous GC identifers: GC02M213960 GC02M214520 GC02M215760 GC02M215998 GC02M215621

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for ABCA12:

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding

cassette (ABC) transporters. ABC proteins transport various molecules across extra- and

intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP,

MRP, ALD, OABP, GCN20, and White). This encoded protein is a member of the ABC1 subfamily, which

is the only major ABC subfamily found exclusively in multicellular eukaryotes. Alternative

splicing of this gene results in multiple transcript variants. [provided by RefSeq]

UniProtKB/Swiss-Prot: ABCAC_HUMAN, Q86UK0

Function: Probable transporter involved in lipid homeostasis

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ABCA12 gene

Entrez Gene cytogenetic band: 2q34 Ensembl cytogenetic band: 2q35 HGNC cytogenetic band: 2q34

ABCA12 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02M215504: (about GC identifiers)

Start:	215,504,511 bp from pter
End:	215,711,396 bp from pter
Size:	206,886 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000002.10 NT_005403.16

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: ABCAC_HUMAN, Q86UK0 (See protein sequence)

Recommended Name: ATP-binding cassette sub-family A member 12

Size: 2595 amino acids; 293251 Da

Subcellular location: Membrane; Multi-pass membrane protein (Potential)

Secondary accessions: Q8IZW6 Q96JT3 Q9Y4M5

Alternative splicing: 2 isoforms: Q86UK0-1 Q86UK0-2 (Additional isoforms seem to exist)

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_056472.2 NP_775099.2

ENSEMBL proteins:

ENSP00000272895 ENSP00000374312

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (ABCA12)
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016020	membrane	IEA	--
GO:0016021	integral to membrane	NAS	12697999

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Antibodies for ABCA12:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (ABCA12), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Novus Biologicals Antibody for ABCA12

Assays for ABCA12:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q86UK0

ProtoNet protein and cluster: Q86UK0

UniProtKB/Swiss-Prot: ABCAC_HUMAN, Q86UK0

Domain: Multifunctional polypeptide with two homologous halves, each containing an hydrophobic

membrane-anchoring domain and an ATP binding cassette (ABC) domain (By similarity)

Similarity: Belongs to the ABC transporter family. ABCA subfamily

Similarity: Contains 2 ABC transporter domains

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ABCA12)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ABCA12)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_015657

Applied Biosystems Silencer® siRNAs for ABCA12

Sigma-Aldrich siRNA and siRNA Panels for ABCA12

Sigma-Aldrich shRNA for ABCA12

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_015657
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_015657
untagged cDNA clones in CMV expression vector (see all 2): NM_015657

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_173076

UniProtKB/Swiss-Prot: ABCAC_HUMAN, Q86UK0

Function: Probable transporter involved in lipid homeostasis

7 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Abca12):

craniofacial	growth/size	homeostasis/metabolism	lethality-postnatal	lethality-prenatal/perinatal
respiratory system	skin/coat/nails

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0005524	ATP binding	NAS	12697999
GO:0016887	ATPase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for ABCA12

3 Interacting proteins for ABCA12 (ENSP00000272895³) via UniProtKB, MINT, and/or STRING

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
TGM1	ENSP00000206765³	STRING (score=.848)
--	ENSP00000366793³	STRING (score=.871)
--	ENSP00000370000³	STRING (score=.76)

About this table

2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006869	lipid transport	NAS	12915478
GO:0019725	cellular homeostasis	NAS	12697999

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for ABCA12
1 Novoseek chemical compound relationship for ABCA12 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
lipid	47.17	20	16847209 (2), 16007249 (2), 18341575 (2), 16481150 (1) (see all 6)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ABCA12)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ABCA12)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_015657

Sigma-Aldrich siRNA and siRNA Panels for ABCA12

Sigma-Aldrich shRNA for ABCA12

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_015657 NM_173076

REFSEQ mRNAs for ABCA12 gene (2 alternative transcripts):

NM_015657.3 NM_173076.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_015657 NM_173076

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_015657
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_015657
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_015657

Additional cDNA sequence:

AF418105.1 AK096597.1 AK123578.1 AL080207.1 AY033486.1 AY219711.1 BC144073.1 CR609974.1

4 DOTS entries:

DT.40283835 DT.102842413 DT.100661918 DT.40236619

20 AceView cDNA sequences:

NM_173076 AY033486 CR609974 AK096597 NM_015657 AF418105 AY219711 BX376131

AK123578 BM745367 CN479111 AI081199 AA487007 CD627181 AL080207 CD627183

CB243323 CF887579 CD627187 CD627179

highest scoring ESTs for ABCA12:

AL080207 AY219711 AA620593 AF418105 AI081199 AK096597 AK123578 AY033486 BE075509 BE144895

Unigene Cluster for ABCA12:

ATP-binding cassette, sub-family A (ABC1), member 12

Hs.134585 [show with all ESTs]

Unigene Representative Sequence: NM_173076

GeneLoc Exon Structure

2 Ensembl transcripts including schematic representations:

ENST00000272895 ENST00000389661

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

ABCA12 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ABCA12

¹ / ² / ³

3 probe-sets matching ABCA12 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
31754_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	AL080207	0.80	1.00	0.91	1
215465_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AL080207	0.80	1.00	0.91	1
215465_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: ACTGTTTGTC

SOURCE GeneReport for Unigene cluster: Hs.134585
Expression variation in blood from EXPOLDB for ABCA12
UniProtKB/Swiss-Prot: ABCAC_HUMAN, Q86UK0
Tissue specificity: Mainly expressed in the stomach, placenta, testis and fetal brain

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ABCA12 gene from 5/7 species (see all 7 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ABCA12¹	--	ATP-binding cassette, sub-family A (ABC1), member 12	91.09(n) 92.02(a)	478900 XM_536058.2 XP_536058.2
chimpanzee (Pan troglodytes)	ABCA12¹	--	ATP-binding cassette, sub-family A (ABC1), member 12	99.4(n) 99.23(a)	459924 XM_516070.2 XP_516070.2
mouse (Mus musculus)	Abca12^{1, 5}	1⁵	ATP-binding cassette, sub-family A (ABC1), member 12^{1, 5}	86.3(n)¹ 89.66(a)¹	74591¹ XM_001002308.2¹ XP_001002308.2¹ AF420436⁵ AK028781⁵ (see all 10)
chicken (Gallus gallus)	ABCA12¹	--	ATP-binding cassette, sub-family A (ABC1), member 12	67.17(n) 62.32(a)	424011 XM_421867.2 XP_421867.2
zebrafish (Danio rerio)	abca12¹	--	ATP-binding cassette, sub-family A (ABC1), member 12	55.76(n) 49.28(a)	558335 XM_681540.3 XP_686632.3

About this table Species with no ortholog for ABCA12

ENSEMBL Gene Tree for ABCA12

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for ABCA12 gene

ABCA13² ABCA2²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/1208 NCBI SNPs in ABCA12 are shown (see all 1208 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 430)

AB	SNP ID	Valid	Chr 2 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs2948984^1,2	A,C,F,H,O	215713207(+)	`AGTACA/CCGCAT`	1	--	ng3¹		4	EU EA WA	410
	rs1464683^1,2	A,C,F,H,O	215605526(-)	`GACCTG/ATTTAA`	2	--	ng3¹ int¹		7	EU EA WA NA	560
	rs1464682^1,2	A,C,F,H,O	215606089(-)	`TGCATT/CGTGAA`	2	--	int¹ ng3¹		7	EU EA WA NA	562
--	rs2103090^1,2	A,C,F,H	215606627(-)	`ggccTA/GTGAAT`	2	--	int¹ ng3¹		4	EU EA WA	414
	rs10206852^1,2	A,C,F,H	215606390(+)	`TTTTTT/CGTCAA`	2	--	int¹ ng3¹ trp³		7	NA EU EA WA	560
	rs2948981^1,2	A,C,F,H	215711652(+)	`GGACCT/CTTGCA`	1	--	ng3¹		4	EU EA WA	416
	rs1464684^1,2	C,F,H,O	215605474(-)	`GTGGTT/CTCCAT`	2	--	int¹ ng3¹		7	EU EA WA NA	556
	rs11891778^1,2	C,F,H	215618819(+)	`CTTTCG/CAAGAA`	1	G/R	mis¹ ese³		8	EU EA WA	838
	rs11890468^1,2	C,F,H	215618857(+)	`CATTCT/CGAAAC`	1	R/Q	mis¹		8	EU EA WA	834
	rs726070^1,2	C,F,H	215521576(-)	`AAAAGG/AATATT`	2	N/D	mis¹ ese³		8	EU EA WA	834

About this table

HapMap Linkage Disequilibrium images for ABCA12 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 607800 disorders: 601277 242500

UniProtKB/Swiss-Prot: ABCAC_HUMAN, Q86UK0

Defects in ABCA12 are the cause of ichthyosis harlequin (HI) [MIM:242500]; also known as

harlequin fetus. HI is a very severe skin disorder in which the neonate is born with a thick

covering of armor-like scales. The skin dries out to form hard diamond-shaped plaques separated by

fissures, resembling 'armor plating'. The normal facial features are severely affected, with

distortion of the lips (eclabion), eyelids (ectropion), ears, and nostrils. Affected babies are

often born prematurely and rarely survive the perinatal period

Defects in ABCA12 are the cause of ichthyosis lamellar type 2 (LI2) [MIM:601277]; also

known as ichthyosis congenita IIB (ICR2B). LI is a non-bullous ichthyosis, a skin disorder

characterized by abnormal cornification of the epidermis. It is one the most severe forms of

ichthyoses apparent at birth and persisting throughout life. LI patients are born encased in a

tight, shiny, translucent covering called collodion membrane. Over the first weeks of life, the

collodion membrane is gradually replaced by generalized large, dark brown, plate-like scales with

minimal to no erythroderma. Tautness of facial skin commonly results in ectropion, eclabium and

scarring alopecia of the scalp. Common complications are severe heat intolerance and recurrent ear

infections

3 Novoseek disease relationships for ABCA12 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
harlequin ichthyosis	98.31	9	16847209 (1), 16675967 (1), 17611579 (1), 18632686 (1) (see all 8)
ichthyosis	75.38	1	18341575 (1)
skin diseases	51.59	3	17611579 (1), 15756637 (1), 16902423 (1)

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1 PharmGKB disease relationship for ABCA12 gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Ichthyosis, Lamellar	CO GN	15756637

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GeneTests: ABCA12

Autosomal Recessive Congenital Ichthyosis

Human Gene Mutation Database: ABCA12
Genetic Association Database: ABCA12
Human Genome Epidemiology Navigator: ABCA12 (1 document)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/25 PubMed articles for ABCA12 gene (see all 25 ):

Mutations in ABCA12 underlie the severe congenital skin disease harlequin ichthyosis. (PubMed id 15756637)^{1, 3, 4, 7} Kelsell D.P....O'Toole E.A. (2005)
Mutations in the transporter ABCA12 are associated with lamellar ichthyosis type 2. (PubMed id 12915478)^{1, 2, 3, 4} Lefevre C....Fischer J. (2003)
Identification and characterization of a novel ABCA subfamily member, ABCA12, located in the lamellar ichthyosis region on 2q34. (PubMed id 12697999)^{1, 3, 4} Annilo T.... Rosier M. (2002)
No genetic association between ATP binding cassette proteins and Japanese sporadic Alzheimer's disease. (PubMed id 15980630)^{3, 6} Ohkubo T....Arai H. (2005)
The human ATP-binding cassette (ABC) transporter superfamily. (PubMed id 11435397)^{2, 3} Dean M....Allikmets R. (2001)
PPAR and LXR activators regulate ABCA12 expression in human keratinocytes. (PubMed id 17611579)^{1, 3} Jiang Y.J....Feingold K.R. (2008)
Expression of the keratinocyte lipid transporter ABCA12 in developing and reconstituted human epidermis. (PubMed id 17591952)^{1, 3} Yamanaka Y....Shimizu H. (2007)
Premature terminal differentiation and a reduction in specific proteases associated with loss of ABCA12 in Harlequin ichthyosis. (PubMed id 19179616)^{1, 3} Thomas A.C....Kelsell D.P. (2009)
ABCA12 is the major harlequin ichthyosis gene. (PubMed id 16902423)^{1, 3} Thomas A.C....Kelsell D.P. (2006)
Novel and recurring ABCA12 mutations associated with harlequin ichthyosis: implications for prenatal diagnosis. (PubMed id 17986308)³ Thomas A.C....Kelsell D.P. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 26154	HGNC: 14637	AceView: ABCA12	Ensembl:ENSG00000144452	euGenes: HUgn26154
ECgene: ABCA12	H-InvDB: ABCA12

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
GeneReviews	http://www.genetests.org/query?gene=ABCA12

Licensable Technologies for ABCA12
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for ABCA12:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ABCA12-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ABCA12		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for ABCA12		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

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	Cell Culture Products		ELISAs
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	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
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ABCA12 Gene

protein-coding GIFtS: 62

Aliases &
Descriptions
for ABCA12

Summaries
for ABCA12

Genomic Location
for ABCA12

Proteins
for ABCA12

Protein Domains/
Families
for ABCA12

Gene Function
for ABCA12

Pathways & Interactions
for ABCA12

Drugs & Compounds
for ABCA12

Transcripts
for ABCA12

Expression
for ABCA12

Orthologs
for ABCA12

Paralogs
for ABCA12

SNPs/Variants
for ABCA12

Disorders & Mutations
for ABCA12

Medical News
for ABCA12

Publications
for ABCA12

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Genome Databases showing ABCA12

Other Databases showing ABCA12

Specialized Databases showing ABCA12

Licensable Technologies
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Services
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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ABCA12 Gene

protein-coding GIFtS: 62

Aliases & Descriptionsfor ABCA12

Summariesfor ABCA12

Genomic Locationfor ABCA12

Proteinsfor ABCA12

Protein Domains/Familiesfor ABCA12

Gene Functionfor ABCA12

Pathways & Interactionsfor ABCA12

Drugs & Compoundsfor ABCA12

Transcriptsfor ABCA12

Expression for ABCA12

Orthologsfor ABCA12

Paralogsfor ABCA12

SNPs/Variantsfor ABCA12

Disorders & Mutationsfor ABCA12

Medical Newsfor ABCA12

Publicationsfor ABCA12

Search for ABCA12

Genome Databases showing ABCA12

Other Databases showing ABCA12

Specialized Databases showing ABCA12

Licensable Technologiesfor ABCA12

Servicesfor ABCA12

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ABCA12

Summaries
for ABCA12

Genomic Location
for ABCA12

Proteins
for ABCA12

Protein Domains/
Families
for ABCA12

Gene Function
for ABCA12

Pathways & Interactions
for ABCA12

Drugs & Compounds
for ABCA12

Transcripts
for ABCA12

Expression
for ABCA12

Orthologs
for ABCA12

Paralogs
for ABCA12

SNPs/Variants
for ABCA12

Disorders & Mutations
for ABCA12

Medical News
for ABCA12

Publications
for ABCA12

Licensable Technologies
for ABCA12

Services
for ABCA12