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Aliases for ABCA10 Gene

Aliases for ABCA10 Gene

  • ATP Binding Cassette Subfamily A Member 10 2 3 5
  • ATP-Binding Cassette, Sub-Family A (ABC1), Member 10 2 3
  • ATP-Binding Cassette A10 3
  • EC 3.6.3.41 63
  • EST698739 3
  • EC 3.6.3 63

External Ids for ABCA10 Gene

Previous GeneCards Identifiers for ABCA10 Gene

  • GC17M066943
  • GC17M070104
  • GC17M067601
  • GC17M067741
  • GC17M064650
  • GC17M067144
  • GC17M062529

Summaries for ABCA10 Gene

Entrez Gene Summary for ABCA10 Gene

  • The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This encoded protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This gene is clustered among 4 other ABC1 family members on 17q24, but neither the substrate nor the function of this gene is known. [provided by RefSeq, Jul 2008]

GeneCards Summary for ABCA10 Gene

ABCA10 (ATP Binding Cassette Subfamily A Member 10) is a Protein Coding gene. Among its related pathways are ABC-family proteins mediated transport and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include ATPase activity and ATPase activity, coupled to transmembrane movement of substances. An important paralog of this gene is ABCA4.

UniProtKB/Swiss-Prot for ABCA10 Gene

  • Probable transporter which may play a role in macrophage lipid homeostasis.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ABCA10 Gene

Genomics for ABCA10 Gene

Regulatory Elements for ABCA10 Gene

Enhancers for ABCA10 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ABCA10 on UCSC Golden Path with GeneCards custom track

Genomic Location for ABCA10 Gene

Chromosome:
17
Start:
69,147,214 bp from pter
End:
69,244,846 bp from pter
Size:
97,633 bases
Orientation:
Minus strand

Genomic View for ABCA10 Gene

Genes around ABCA10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ABCA10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ABCA10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ABCA10 Gene

Proteins for ABCA10 Gene

  • Protein details for ABCA10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WWZ4-ABCAA_HUMAN
    Recommended name:
    ATP-binding cassette sub-family A member 10
    Protein Accession:
    Q8WWZ4
    Secondary Accessions:
    • C9JZH2
    • C9K035
    • Q6PIQ6
    • Q7Z2I9
    • Q7Z7P7
    • Q86TD2

    Protein attributes for ABCA10 Gene

    Size:
    1543 amino acids
    Molecular mass:
    175790 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ABCA10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ABCA10 Gene

Proteomics data for ABCA10 Gene at MOPED

Selected DME Specific Peptides for ABCA10 Gene

Post-translational modifications for ABCA10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for ABCA10 Gene

Gene Families for ABCA10 Gene

Protein Domains for ABCA10 Gene

Suggested Antigen Peptide Sequences for ABCA10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WWZ4

UniProtKB/Swiss-Prot:

ABCAA_HUMAN :
  • Contains 2 ABC transporter domains.
  • Belongs to the ABC transporter superfamily. ABCA family.
Domain:
  • Contains 2 ABC transporter domains.
Family:
  • Belongs to the ABC transporter superfamily. ABCA family.
genes like me logo Genes that share domains with ABCA10: view

Function for ABCA10 Gene

Molecular function for ABCA10 Gene

UniProtKB/Swiss-Prot Function:
Probable transporter which may play a role in macrophage lipid homeostasis.
UniProtKB/Swiss-Prot Induction:
Down-regulated by cholesterol loading of macrophages.

Enzyme Numbers (IUBMB) for ABCA10 Gene

Phenotypes for ABCA10 Gene

genes like me logo Genes that share phenotypes with ABCA10: view

Animal Model Products

CRISPR Products

miRNA for ABCA10 Gene

miRTarBase miRNAs that target ABCA10

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ABCA10 Gene

Localization for ABCA10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ABCA10 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ABCA10 Gene COMPARTMENTS Subcellular localization image for ABCA10 gene
Compartment Confidence
plasma membrane 3

No data available for Gene Ontology (GO) - Cellular Components for ABCA10 Gene

Pathways & Interactions for ABCA10 Gene

genes like me logo Genes that share pathways with ABCA10: view

Pathways by source for ABCA10 Gene

Interacting Proteins for ABCA10 Gene

Gene Ontology (GO) - Biological Process for ABCA10 Gene

None

No data available for SIGNOR curated interactions for ABCA10 Gene

Drugs & Compounds for ABCA10 Gene

No Compound Related Data Available

Transcripts for ABCA10 Gene

Unigene Clusters for ABCA10 Gene

ATP-binding cassette, sub-family A (ABC1), member 10:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ABCA10 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21a · 21b · 21c · 21d
SP1: - -
SP2:
SP3: -
SP4:
SP5: -
SP6:

Relevant External Links for ABCA10 Gene

GeneLoc Exon Structure for
ABCA10
ECgene alternative splicing isoforms for
ABCA10

Expression for ABCA10 Gene

mRNA expression in normal human tissues for ABCA10 Gene

mRNA differential expression in normal tissues according to GTEx for ABCA10 Gene

This gene is overexpressed in Nerve - Tibial (x5.8) and Ovary (x5.3).

Protein differential expression in normal tissues from HIPED for ABCA10 Gene

This gene is overexpressed in Blymphocyte (32.4), Neutrophil (18.1), Monocytes (9.3), and Tlymphocyte (9.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ABCA10 Gene



SOURCE GeneReport for Unigene cluster for ABCA10 Gene Hs.25377

mRNA Expression by UniProt/SwissProt for ABCA10 Gene

Q8WWZ4-ABCAA_HUMAN
Tissue specificity: Widely expressed. Highly expressed in skeletal muscle, heart, brain and gastrointestinal tract.
genes like me logo Genes that share expression patterns with ABCA10: view

Protein tissue co-expression partners for ABCA10 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for ABCA10 Gene

Orthologs for ABCA10 Gene

This gene was present in the common ancestor of animals.

Orthologs for ABCA10 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ABCA10 35
  • 77.23 (n)
  • 69.36 (a)
ABCA10 36
  • 67 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ABCA10 35
  • 99.05 (n)
  • 98.28 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 59 (a)
ManyToMany
-- 36
  • 57 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Abca8a 36
  • 54 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 57 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 36
  • 45 (a)
ManyToMany
-- 36
  • 51 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 43 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii abch1 36
  • 17 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG42816 36
  • 22 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea abt-5 36
  • 19 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 29 (a)
OneToMany
Species with no ortholog for ABCA10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ABCA10 Gene

ENSEMBL:
Gene Tree for ABCA10 (if available)
TreeFam:
Gene Tree for ABCA10 (if available)

Paralogs for ABCA10 Gene

Paralogs for ABCA10 Gene

Pseudogenes.org Pseudogenes for ABCA10 Gene

genes like me logo Genes that share paralogs with ABCA10: view

Variants for ABCA10 Gene

Sequence variations from dbSNP and Humsavar for ABCA10 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs9909216 - 69,216,282(+) AATTG(A/C/G)GATTG reference, missense
rs11657804 - 69,214,851(+) TGTAA(C/T)CTGAG reference, missense
rs4968849 - 69,182,175(+) TCTCC(A/G)TTTGA reference, missense
rs10491178 - 69,153,832(-) TTTCA(C/T)GGTAC reference, stop-gained
rs981452 -- 69,163,291(+) AGGTG(C/G)GCAGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ABCA10 Gene

Variant ID Type Subtype PubMed ID
nsv470598 CNV Loss 18288195
nsv2128 CNV Insertion 18451855
nsv457888 CNV Loss 19166990
nsv2129 CNV Insertion 18451855
nsv516799 CNV Loss 19592680
nsv833527 CNV Gain+Loss 17160897

Variation tolerance for ABCA10 Gene

Residual Variation Intolerance Score: 97.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.10; 95.11% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ABCA10 Gene

HapMap Linkage Disequilibrium report
ABCA10
Human Gene Mutation Database (HGMD)
ABCA10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ABCA10 Gene

Disorders for ABCA10 Gene

Relevant External Links for ABCA10

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ABCA10

No disorders were found for ABCA10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ABCA10 Gene

Publications for ABCA10 Gene

  1. ABCA10, a novel cholesterol-regulated ABCA6-like ABC transporter. (PMID: 12821155) Wenzel J.J. … Schmitz G. (Biochem. Biophys. Res. Commun. 2003) 2 3 4 23 67
  2. The human ATP-binding cassette (ABC) transporter superfamily. (PMID: 11435397) Dean M. … Allikmets R. (Genome Res. 2001) 2 3
  3. A comprehensive evaluation of the role of genetic variation in follicular lymphoma survival. (PMID: 25294155) Baecklund F. … Smedby K.E. (BMC Med. Genet. 2014) 3
  4. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PMID: 21145461) Bennett E.J. … Harper J.W. (Cell 2010) 3
  5. Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry. (PMID: 16094384) Tao W.A. … Aebersold R. (Nat. Methods 2005) 3

Products for ABCA10 Gene

Sources for ABCA10 Gene

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