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ABCA10 Gene

protein-coding GIFtS: 44

GC17M064650

ATP-binding cassette, sub-family A (ABC1), member 10
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
EST698739 ^¹, ²

Descriptions
ATP-binding cassette A10 ^²
ATP-binding cassette sub-family A member 10 ^²
ATP-binding cassette, sub-family A (ABC1), member 10 ^²
ATP-binding cassette, sub-family A, member 10 ^²

External Ids
HGNC: 30¹
Entrez Gene: 10349²
UniProtKB: Q8WWZ4³
Ensembl: ENSG00000154263⁷

Search outside databases for aliases for ABCA10 gene

Previous GC identifers: GC17M066943 GC17M070104 GC17M067601 GC17M067741

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for ABCA10:

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding

cassette (ABC) transporters. ABC proteins transport various molecules across extra- and

intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP,

MRP, ALD, OABP, GCN20, and White). This encoded protein is a member of the ABC1 subfamily. Members

of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular

eukaryotes. This gene is clustered among 4 other ABC1 family members on 17q24, but neither the

substrate nor the function of this gene is known. [provided by RefSeq]

UniProtKB/Swiss-Prot: ABCAA_HUMAN, Q8WWZ4

Function: Probable transporter which may play a role in macrophage lipid homeostasis

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ABCA10 gene

Entrez Gene cytogenetic band: 17q24 Ensembl cytogenetic band: 17q24.3 HGNC cytogenetic band: 17q24

ABCA10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17M064650: (about GC identifiers)

Start:	64,655,743 bp from pter
End:	64,752,551 bp from pter
Size:	96,809 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000017.9 NT_010641.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: ABCAA_HUMAN, Q8WWZ4 (See protein sequence)

Recommended Name: ATP-binding cassette sub-family A member 10

Size: 1543 amino acids; 175746 Da

Subcellular location: Membrane; Multi-pass membrane protein (Potential)

Secondary accessions: Q6PIQ6 Q7Z2I9 Q7Z7P7 Q86TD2

Alternative splicing: 5 isoforms: Q8WWZ4-1 Q8WWZ4-2 Q8WWZ4-3 Q8WWZ4-4 Q8WWZ4-5

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_525021.3

ENSEMBL proteins:

ENSP00000269081

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (ABCA10)
	Human Recombinant Proteins from Abnova (ABCA10)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016020	membrane	IEA	--
GO:0016021	integral to membrane	IEA	--

About this table

Antibodies for ABCA10:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for ABCA10
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (ABCA10), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (ABCA10)
	Novus Biologicals Antibodies for ABCA10

Assays for ABCA10:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q8WWZ4

ProtoNet protein and cluster: Q8WWZ4

UniProtKB/Swiss-Prot: ABCAA_HUMAN, Q8WWZ4

Similarity: Belongs to the ABC transporter family. ABCA subfamily

Similarity: Contains 2 ABC transporter domains

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ABCA10)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ABCA10)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_080282

Applied Biosystems Silencer® siRNAs for ABCA10

Sigma-Aldrich siRNA and siRNA Panels for ABCA10

Sigma-Aldrich shRNA for ABCA10

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_080282
Myc/DDK tagged cDNA clone in CMV expression vector: NM_080282
untagged cDNA clone in CMV expression vector: NM_080282

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_080282

UniProtKB/Swiss-Prot: ABCAA_HUMAN, Q8WWZ4

Function: Probable transporter which may play a role in macrophage lipid homeostasis

Induction: Down-regulated by cholesterol loading of macrophages

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0005524	ATP binding	IEA	--
GO:0016887	ATPase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for ABCA10

1 Gene Ontology (GO) biological process term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006810	transport	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for ABCA10

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ABCA10)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ABCA10)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_080282

Sigma-Aldrich siRNA and siRNA Panels for ABCA10

Sigma-Aldrich shRNA for ABCA10

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_080282

REFSEQ mRNAs for ABCA10 gene:

NM_080282.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_080282

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_080282
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_080282
                                 untagged cDNA clone in CMV expression vector: NM_080282

Additional cDNA sequence:

AK298508.1 AK310858.1 AL832004.2 AY028900.1 AY247065.1 BC031026.1 BC051320.1 BC144124.1

10 DOTS entries:

DT.100777105 DT.100029318 DT.100777104 DT.100029319 DT.92415839 DT.91981788 DT.95358004 DT.425145

DT.100777106 DT.303146

24/208 AceView cDNA sequences (see all 208 ):

BF061307 CA773849 BI492210 AL698749 AI350336 AW440582 AY247065 BQ000362

AW189609 AI698175 BQ441353 CD629442 AI568925 BX280304 AV718464 BU625990

AW139910 BC070126 BC029426 AI942287 CD629440 NM_080282 AB067475 BU146839

highest scoring ESTs for ABCA10:

AY028900 AY247065 AL832004 BC031026 BC051320 BG288838 BG566233 BQ000362 BQ690109 BQ690369

Unigene Cluster for ABCA10:

ATP-binding cassette, sub-family A (ABC1), member 10

Hs.25377 [show with all ESTs]

Unigene Representative Sequence: NM_080282

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for ABCA10 (see all 6 )

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14	^	15	^	16	^	17	^	18	^	19	^	20a	·	20b	^	21a	·	21b	·	21c	·	21d
SP1:																																			-				-
SP2:
SP3:																																							-
SP4:
SP5:																																							-

About this scheme

ECgene alternative splicing isoforms for ABCA10

1 Ensembl transcript including schematic representation:

ENST00000269081

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

ABCA10 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ABCA10

¹ / ³ Data from (Publications) and GNF BioGPS
About these images

About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.25377
UniProtKB/Swiss-Prot: ABCAA_HUMAN, Q8WWZ4
Tissue specificity: Widely expressed. Highly expressed in skeletal muscle, heart, brain and
gastrointestinal tract

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

ENSEMBL Gene Tree for ABCA10

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for ABCA10 gene

ABCA9² ABCA6² ABCA5² ABCA8²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/487 NCBI SNPs in ABCA10 are shown (see all 487 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 157)

AB	SNP ID	Valid	Chr 17 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs11657804^1,2	A,C,F,H	64722587(+)	`TGTAAT/CCTGAG`	1	V/I	mis¹		8	EU EA WA	834
	rs9909216^1,2	A,C,F,H	64724018(+)	`AATTGG/AGATTG`	1	S/P	mis¹ ese³		12	EU EA WA NA	1056
--	rs1974577^1,2	A,C,F,H	64656279(+)	`ACCGAA/TAACCA`	1	--	ut3¹ ese³		6	EU EA NA	428
--	rs1974576^1,2	A,C,F,H	64656223(+)	`AAAAAA/CCTCAT`	1	--	ut3¹ ese³		8	MN EU EA WA NA	742
	rs4968843^1,2	C,F,H	64655792(+)	`AACCCA/GAACGT`	1	--	ut3¹		11	EU EA WA NA	980
	rs10491178^1,2	C,F,H	64661568(-)	`TTTCAC/TGGTAC`	1	R/X	non¹ ese³		20	NS EU EA WA NA	1498
	rs4968841^1,2	A,F,H	64655509(+)	`gcaatT/Ccatga`	1	--	ng5¹		4	EU EA WA	412
	rs4968849^1,2	C,F,H	64689911(+)	`TCTCCG/ATTTGA`	1	T/M	mis¹ ese³		8	EU EA WA	836
	rs9302891^1,2	C,F,H	64736442(+)	`GTTTTT/GATTCA`	1	--	ut5¹ ese³		4	EU EA WA	420
	rs2233768^1,2	F,H	64656171(+)	`GAATCC/TGAGTA`	1	--	ut3¹ ese³		4	EU EA WA	408

About this table

HapMap Linkage Disequilibrium images for ABCA10 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 612508

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

9 PubMed articles for ABCA10 gene:

ABCA10, a novel cholesterol-regulated ABCA6-like ABC transporter. (PubMed id 12821155)^{1, 2, 3, 4} Wenzel J.J....Schmitz G. (2003)
Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry. (PubMed id 16094384)^{3, 4} Tao W.A.... Aebersold R. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
The human ATP-binding cassette (ABC) transporter superfamily. (PubMed id 11435397)^{2, 3} Dean M....Allikmets R. (2001)
Automated phosphoproteome analysis for cultured cancer cells by two- dimensional nanoLC-MS using a calcined titania/C18 biphasic column. (PubMed id 18187866)⁴ Imami K.... Ishihama Y. (2008)
The full-ORF clone resource of the German cDNA Consortium. (PubMed id 17974005)⁴ Bechtel S....Schupp I. (2007)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)
Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )⁴ Aoki H.... Hino O. (2000)
Characterization of the human ABC superfamily: isolation and mapping of 21 new genes using the expressed sequence tags database. (PubMed id 8894702)³ Allikmets R....Dean M. (1996)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 10349	HGNC: 30	AceView: ABCA5andABCA10	Ensembl:ENSG00000154263	euGenes: HUgn10349
ECgene: ABCA10	H-InvDB: ABCA10

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for ABCA10
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for ABCA10:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ABCA10-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ABCA10		Antibodies for ABCA10
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for ABCA10		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (ABCA10)
	Antibodies (ABCA10)
	Chimera RNAi (ABCA10)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (ABCA10)
	Antibodies (ABCA10)

Search OriGene for ABCA10

Search Tocris compounds for ABCA10

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for ABCA10

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ABCA10 Gene

protein-coding GIFtS: 44

Aliases &
Descriptions
for ABCA10

Summaries
for ABCA10

Genomic Location
for ABCA10

Proteins
for ABCA10

Protein Domains/
Families
for ABCA10

Gene Function
for ABCA10

Pathways & Interactions
for ABCA10

Drugs & Compounds
for ABCA10

Transcripts
for ABCA10

Expression
for ABCA10

Orthologs
for ABCA10

Paralogs
for ABCA10

SNPs/Variants
for ABCA10

Disorders & Mutations
for ABCA10

Medical News
for ABCA10

Publications
for ABCA10

Search for ABCA10

Genome Databases showing ABCA10

Other Databases showing ABCA10

Specialized Databases showing ABCA10

Licensable Technologies
for ABCA10

Services
for ABCA10

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ABCA10 Gene

protein-coding GIFtS: 44

Aliases & Descriptionsfor ABCA10

Summariesfor ABCA10

Genomic Locationfor ABCA10

Proteinsfor ABCA10

Protein Domains/Familiesfor ABCA10

Gene Functionfor ABCA10

Pathways & Interactionsfor ABCA10

Drugs & Compoundsfor ABCA10

Transcriptsfor ABCA10

Expression for ABCA10

Orthologsfor ABCA10

Paralogsfor ABCA10

SNPs/Variantsfor ABCA10

Disorders & Mutationsfor ABCA10

Medical Newsfor ABCA10

Publicationsfor ABCA10

Search for ABCA10

Genome Databases showing ABCA10

Other Databases showing ABCA10

Specialized Databases showing ABCA10

Licensable Technologiesfor ABCA10

Servicesfor ABCA10

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ABCA10

Summaries
for ABCA10

Genomic Location
for ABCA10

Proteins
for ABCA10

Protein Domains/
Families
for ABCA10

Gene Function
for ABCA10

Pathways & Interactions
for ABCA10

Drugs & Compounds
for ABCA10

Transcripts
for ABCA10

Expression
for ABCA10

Orthologs
for ABCA10

Paralogs
for ABCA10

SNPs/Variants
for ABCA10

Disorders & Mutations
for ABCA10

Medical News
for ABCA10

Publications
for ABCA10

Licensable Technologies
for ABCA10

Services
for ABCA10