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Aliases for ABCA10 Gene

Aliases for ABCA10 Gene

  • ATP-Binding Cassette, Sub-Family A (ABC1), Member 10 2 3
  • ATP-Binding Cassette Sub-Family A Member 10 3
  • ATP-Binding Cassette A10 3
  • EC 63
  • EST698739 3
  • EC 3.6.3 63

External Ids for ABCA10 Gene

Previous GeneCards Identifiers for ABCA10 Gene

  • GC17M066943
  • GC17M070104
  • GC17M067601
  • GC17M067741
  • GC17M064650
  • GC17M067144
  • GC17M062529

Summaries for ABCA10 Gene

Entrez Gene Summary for ABCA10 Gene

  • The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This encoded protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This gene is clustered among 4 other ABC1 family members on 17q24, but neither the substrate nor the function of this gene is known. [provided by RefSeq, Jul 2008]

GeneCards Summary for ABCA10 Gene

ABCA10 (ATP-Binding Cassette, Sub-Family A (ABC1), Member 10) is a Protein Coding gene. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and ABC-family proteins mediated transport. GO annotations related to this gene include ATPase activity. An important paralog of this gene is ABCA4.

UniProtKB/Swiss-Prot for ABCA10 Gene

  • Probable transporter which may play a role in macrophage lipid homeostasis

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ABCA10 Gene

Genomics for ABCA10 Gene

Regulatory Elements for ABCA10 Gene

Genomic Location for ABCA10 Gene

69,147,214 bp from pter
69,244,846 bp from pter
97,633 bases
Minus strand

Genomic View for ABCA10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ABCA10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ABCA10 Gene

Proteins for ABCA10 Gene

  • Protein details for ABCA10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    ATP-binding cassette sub-family A member 10
    Protein Accession:
    Secondary Accessions:
    • C9JZH2
    • C9K035
    • Q6PIQ6
    • Q7Z2I9
    • Q7Z7P7
    • Q86TD2

    Protein attributes for ABCA10 Gene

    1543 amino acids
    Molecular mass:
    175790 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ABCA10 Gene


neXtProt entry for ABCA10 Gene

Proteomics data for ABCA10 Gene at MOPED

Selected DME Specific Peptides for ABCA10 Gene

Post-translational modifications for ABCA10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ABCA10 Gene

Domains for ABCA10 Gene

Gene Families for ABCA10 Gene

  • ABCA :ATP binding cassette transporters / subfamily A

Protein Domains for ABCA10 Gene

Suggested Antigen Peptide Sequences for ABCA10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q8WWZ4
  • Contains 2 ABC transporter domains.
  • Belongs to the ABC transporter superfamily. ABCA family.
genes like me logo Genes that share domains with ABCA10: view

Function for ABCA10 Gene

Molecular function for ABCA10 Gene

UniProtKB/Swiss-Prot Function:
Probable transporter which may play a role in macrophage lipid homeostasis
UniProtKB/Swiss-Prot Induction:
Down-regulated by cholesterol loading of macrophages.

Enzyme Numbers (IUBMB) for ABCA10 Gene

Gene Ontology (GO) - Molecular Function for ABCA10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
GO:0016887 ATPase activity --
GO:0042626 ATPase activity, coupled to transmembrane movement of substances IBA --
genes like me logo Genes that share ontologies with ABCA10: view

Phenotypes for ABCA10 Gene

GenomeRNAi human phenotypes for ABCA10:
genes like me logo Genes that share phenotypes with ABCA10: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ABCA10

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ABCA10 Gene

Localization for ABCA10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ABCA10 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for ABCA10 Gene COMPARTMENTS Subcellular localization image for ABCA10 gene
Compartment Confidence
plasma membrane 3
cytosol 1

Gene Ontology (GO) - Cellular Components for ABCA10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
GO:0043231 intracellular membrane-bounded organelle IBA --
genes like me logo Genes that share ontologies with ABCA10: view

Pathways for ABCA10 Gene

genes like me logo Genes that share pathways with ABCA10: view

Pathways by source for ABCA10 Gene

Interacting Proteins for ABCA10 Gene

Gene Ontology (GO) - Biological Process for ABCA10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006200 obsolete ATP catabolic process --
GO:0006810 transport --
GO:0006869 lipid transport IBA --
GO:0008152 metabolic process IEA --
GO:0055085 transmembrane transport IBA --
genes like me logo Genes that share ontologies with ABCA10: view

Transcripts for ABCA10 Gene

Unigene Clusters for ABCA10 Gene

ATP-binding cassette, sub-family A (ABC1), member 10:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ABCA10

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ABCA10 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21a · 21b · 21c · 21d
SP1: - -
SP3: -
SP5: -

Relevant External Links for ABCA10 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ABCA10 Gene

mRNA expression in normal human tissues for ABCA10 Gene

mRNA differential expression in normal tissues according to GTEx for ABCA10 Gene

This gene is overexpressed in Nerve - Tibial (5.8) and Ovary (5.3).

Protein differential expression in normal tissues for ABCA10 Gene

This gene is overexpressed in Blymphocyte (32.4), Neutrophil (18.1), Monocytes (9.3), and Tlymphocyte (9.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ABCA10 Gene

SOURCE GeneReport for Unigene cluster for ABCA10 Gene Hs.25377

mRNA Expression by UniProt/SwissProt for ABCA10 Gene

Tissue specificity: Widely expressed. Highly expressed in skeletal muscle, heart, brain and gastrointestinal tract.
genes like me logo Genes that share expressions with ABCA10: view

Expression partners for ABCA10 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for ABCA10 Gene

Orthologs for ABCA10 Gene

This gene was present in the common ancestor of animals.

Orthologs for ABCA10 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ABCA10 35
  • 77.23 (n)
  • 69.36 (a)
ABCA10 36
  • 67 (a)
(Pan troglodytes)
Mammalia ABCA10 35
  • 99.05 (n)
  • 98.28 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 59 (a)
-- 36
  • 57 (a)
(Mus musculus)
Mammalia Abca8a 36
  • 54 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 57 (a)
(Gallus gallus)
Aves -- 36
  • 45 (a)
-- 36
  • 51 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 43 (a)
(Danio rerio)
Actinopterygii abch1 36
  • 17 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG42816 36
  • 22 (a)
(Caenorhabditis elegans)
Secernentea abt-5 36
  • 19 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 29 (a)
Species with no ortholog for ABCA10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ABCA10 Gene

Gene Tree for ABCA10 (if available)
Gene Tree for ABCA10 (if available)

Paralogs for ABCA10 Gene

Paralogs for ABCA10 Gene Pseudogenes for ABCA10 Gene

genes like me logo Genes that share paralogs with ABCA10: view

Variants for ABCA10 Gene

Sequence variations from dbSNP and Humsavar for ABCA10 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs721813 -- 69,150,591(-) TTAAG(A/G)AGGGT intron-variant
rs740518 -- 69,151,439(+) TATAA(C/T)AAATA intron-variant
rs740519 -- 69,151,809(-) GTGTG(C/T)AAATG intron-variant
rs740520 -- 69,174,595(+) AAAAA(A/G)TGATC intron-variant
rs764178 -- 69,202,909(+) ATTTT(C/T)CAGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ABCA10 Gene

Variant ID Type Subtype PubMed ID
nsv470598 CNV Loss 18288195
nsv2128 CNV Insertion 18451855
nsv457888 CNV Loss 19166990
nsv2129 CNV Insertion 18451855
nsv516799 CNV Loss 19592680
nsv833527 CNV Gain+Loss 17160897

Relevant External Links for ABCA10 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ABCA10 Gene

Disorders for ABCA10 Gene

No disorders were found for ABCA10 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for ABCA10 Gene

Publications for ABCA10 Gene

  1. ABCA10, a novel cholesterol-regulated ABCA6-like ABC transporter. (PMID: 12821155) Wenzel J.J. … Schmitz G. (Biochem. Biophys. Res. Commun. 2003) 2 3 4 23
  2. The human ATP-binding cassette (ABC) transporter superfamily. (PMID: 11435397) Dean M. … Allikmets R. (Genome Res. 2001) 2 3
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry. (PMID: 16094384) Tao W.A. … Aebersold R. (Nat. Methods 2005) 3
  5. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PMID: 21145461) Bennett E.J. … Harper J.W. (Cell 2010) 3

Products for ABCA10 Gene

Sources for ABCA10 Gene

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