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Aliases for AATK Gene

Aliases for AATK Gene

  • Apoptosis Associated Tyrosine Kinase 2 3 5
  • Lemur Tyrosine Kinase 1 2 3 4
  • Protein Phosphatase 1, Regulatory Subunit 77 2 3
  • Brain Apoptosis-Associated Tyrosine Kinase 3 4
  • CDK5-Binding Protein 3 4
  • P35-Binding Protein 3 4
  • EC 4 61
  • AATYK 3 4
  • LMTK1 3 4
  • P35BP 3 4
  • LMR1 3 4
  • Serine/Threonine-Protein Kinase LMTK1 3
  • Apoptosis-Associated Tyrosine Kinase 4
  • EC 2.7.11 61
  • KIAA0641 4
  • PPP1R77 3
  • AATYK1 3

External Ids for AATK Gene

Previous GeneCards Identifiers for AATK Gene

  • GC17U990147
  • GC17M082453
  • GC17M079653
  • GC17M079791
  • GC17M076707
  • GC17M079091

Summaries for AATK Gene

Entrez Gene Summary for AATK Gene

  • The protein encoded by this gene contains a tyrosine kinase domain at the N-terminus and a proline-rich domain at the C-terminus. This gene is induced during apoptosis, and expression of this gene may be a necessary pre-requisite for the induction of growth arrest and/or apoptosis of myeloid precursor cells. This gene has been shown to produce neuronal differentiation in a neuroblastoma cell line. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2011]

GeneCards Summary for AATK Gene

AATK (Apoptosis Associated Tyrosine Kinase) is a Protein Coding gene. Diseases associated with AATK include Neuroblastoma. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is LMTK2.

UniProtKB/Swiss-Prot for AATK Gene

  • May be involved in neuronal differentiation.

Gene Wiki entry for AATK Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AATK Gene

Genomics for AATK Gene

Regulatory Elements for AATK Gene

Enhancers for AATK Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F081125 1.5 FANTOM5 Ensembl ENCODE 32.5 +36.1 36103 9.8 TBP ZNF133 DMAP1 BRCA1 RAD21 RARA RFX5 GLIS2 SCRT2 RCOR1 AATK CEP131 LOC100294362 ENSG00000262049 AATK-AS1 GPS1 ARL16 RFNG ENSG00000262877 BAIAP2
GH17F081148 1.1 FANTOM5 Ensembl 21.3 +15.6 15584 3.4 ZNF146 KLF1 MAX MNT ZIC2 ZFHX2 MYC EGR2 AATK TEPSIN LOC105371924 GC17P081143 AATK-AS1
GH17F081101 0.9 Ensembl ENCODE 12.6 +64.4 64393 1.0 HDGF PKNOX1 MLX WRNIP1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 SLC30A9 AATK MIR1250 CEP131 GC17M081121 BAIAP2
GH17F081086 0.2 ENCODE 12.4 +78.6 78623 2.2 KLF1 ZNF600 MIR1250 AATK BAIAP2 CEP131 GC17M081121
GH17F081152 1.2 FANTOM5 Ensembl ENCODE 12 +12.9 12864 2.0 HDAC1 PKNOX1 ATF1 TBL1XR1 CREB3L1 ZBTB40 RAD21 CREM ELF1 KLF16 AATK LOC105371924 TEPSIN GC17P081143 AATK-AS1
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around AATK on UCSC Golden Path with GeneCards custom track

Genomic Location for AATK Gene

81,117,295 bp from pter
81,166,077 bp from pter
48,783 bases
Minus strand

Genomic View for AATK Gene

Genes around AATK on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AATK Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AATK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AATK Gene

Proteins for AATK Gene

  • Protein details for AATK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Serine/threonine-protein kinase LMTK1
    Protein Accession:
    Secondary Accessions:
    • O75136
    • Q6ZN31
    • Q86X28

    Protein attributes for AATK Gene

    1374 amino acids
    Molecular mass:
    144569 Da
    Quaternary structure:
    • Interacts with CDK5.

    Alternative splice isoforms for AATK Gene


neXtProt entry for AATK Gene

Selected DME Specific Peptides for AATK Gene


Post-translational modifications for AATK Gene

Antibody Products

  • Abcam antibodies for AATK
  • Santa Cruz Biotechnology (SCBT) Antibodies for AATK

Domains & Families for AATK Gene

Suggested Antigen Peptide Sequences for AATK Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. Tyr protein kinase family.
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. Tyr protein kinase family.
genes like me logo Genes that share domains with AATK: view

Function for AATK Gene

Molecular function for AATK Gene

GENATLAS Biochemistry:
apoptosis associated tyrosine-kinase (AATYK),murine homolog
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot Function:
May be involved in neuronal differentiation.
UniProtKB/Swiss-Prot Induction:
Up-regulated during apoptosis.

Enzyme Numbers (IUBMB) for AATK Gene

Gene Ontology (GO) - Molecular Function for AATK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity IEA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with AATK: view
genes like me logo Genes that share phenotypes with AATK: view

Animal Models for AATK Gene

MGI Knock Outs for AATK:

Animal Model Products

  • Taconic Biosciences Mouse Models for AATK

miRNA for AATK Gene

miRTarBase miRNAs that target AATK

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for AATK Gene

Localization for AATK Gene

Subcellular locations from UniProtKB/Swiss-Prot for AATK Gene

Membrane; Single-pass type I membrane protein. Cytoplasm. Cytoplasm, perinuclear region. Note=Predominantly perinuclear.

Subcellular locations from

Jensen Localization Image for AATK Gene COMPARTMENTS Subcellular localization image for AATK gene
Compartment Confidence
endosome 3
mitochondrion 3
plasma membrane 3
cytosol 2
endoplasmic reticulum 2
cytoskeleton 1
extracellular 1
lysosome 1
nucleus 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for AATK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0048471 perinuclear region of cytoplasm IEA --
genes like me logo Genes that share ontologies with AATK: view

Pathways & Interactions for AATK Gene

SuperPathways for AATK Gene

No Data Available

SIGNOR curated interactions for AATK Gene


Gene Ontology (GO) - Biological Process for AATK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0016310 phosphorylation IEA --
genes like me logo Genes that share ontologies with AATK: view

No data available for Pathways by source for AATK Gene

Transcripts for AATK Gene

mRNA/cDNA for AATK Gene

(11) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(10) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for AATK Gene

Apoptosis-associated tyrosine kinase:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for AATK Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b
SP2: -
SP3: -
SP4: -

Relevant External Links for AATK Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for AATK Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for AATK Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for AATK Gene

This gene is overexpressed in Nerve - Tibial (x8.4) and Brain - Spinal cord (cervical c-1) (x5.0).

Protein differential expression in normal tissues from HIPED for AATK Gene

This gene is overexpressed in Ovary (35.1), Adipocyte (23.6), and NK cells (10.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for AATK Gene

Protein tissue co-expression partners for AATK Gene

NURSA nuclear receptor signaling pathways regulating expression of AATK Gene:


SOURCE GeneReport for Unigene cluster for AATK Gene:


mRNA Expression by UniProt/SwissProt for AATK Gene:

Tissue specificity: Expressed in brain.
genes like me logo Genes that share expression patterns with AATK: view

Primer Products

Orthologs for AATK Gene

This gene was present in the common ancestor of chordates.

Orthologs for AATK Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia AATK 34 35
  • 95.69 (n)
(Canis familiaris)
Mammalia AATK 34 35
  • 83.36 (n)
(Bos Taurus)
Mammalia AATK 34 35
  • 81.47 (n)
(Rattus norvegicus)
Mammalia Aatk 34
  • 78.05 (n)
(Mus musculus)
Mammalia Aatk 34 16 35
  • 77.8 (n)
(Monodelphis domestica)
Mammalia AATK 35
  • 54 (a)
(Gallus gallus)
Aves AATK 34 35
  • 68.58 (n)
(Anolis carolinensis)
Reptilia AATK 35
  • 50 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia aatk 34
  • 56.87 (n)
(Danio rerio)
Actinopterygii aatkb 34 35
  • 60.55 (n)
aatka 35
  • 37 (a)
Species where no ortholog for AATK was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for AATK Gene

Gene Tree for AATK (if available)
Gene Tree for AATK (if available)

Paralogs for AATK Gene

Paralogs for AATK Gene

(4) SIMAP similar genes for AATK Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with AATK: view

Variants for AATK Gene

Sequence variations from dbSNP and Humsavar for AATK Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
VAR_032679 An ovarian mucinous carcinoma sample
VAR_032680 A lung adenocarcinoma sample
VAR_032681 An ovarian mucinous carcinoma sample
rs10593953 -- 81,148,907(+) CTAGT(-/GAG)GAGCT intron-variant
rs10655340 -- 81,119,256(+) GGGAA(-/GGAGC)GGAGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for AATK Gene

Variant ID Type Subtype PubMed ID
dgv191e215 CNV deletion 23714750
dgv3292n100 CNV gain 25217958
dgv46n68 CNV loss 17160897
esv1011110 CNV insertion 20482838
esv1314431 CNV deletion 17803354
esv2148507 CNV deletion 18987734
esv2278259 CNV deletion 18987734
esv26223 CNV gain+loss 19812545
esv2668695 CNV deletion 23128226
esv2716425 CNV deletion 23290073
esv2716426 CNV deletion 23290073
esv2716427 CNV deletion 23290073
esv2716428 CNV deletion 23290073
esv2716430 CNV deletion 23290073
esv2716431 CNV deletion 23290073
esv2716432 CNV deletion 23290073
esv2716433 CNV deletion 23290073
esv2716434 CNV deletion 23290073
esv2758707 CNV gain 17122850
esv3307516 CNV mobile element insertion 20981092
esv3414086 CNV duplication 20981092
esv3426009 CNV insertion 20981092
esv3554872 CNV deletion 23714750
esv3582923 CNV loss 25503493
esv3641392 CNV gain 21293372
nsv1057306 CNV loss 25217958
nsv1065052 CNV gain 25217958
nsv1066947 CNV loss 25217958
nsv1116243 CNV deletion 24896259
nsv1127604 CNV deletion 24896259
nsv1131341 CNV deletion 24896259
nsv1131342 CNV deletion 24896259
nsv1140228 CNV deletion 24896259
nsv1141310 CNV duplication 24896259
nsv1149351 CNV deletion 26484159
nsv428351 CNV gain 18775914
nsv470619 CNV loss 18288195
nsv523417 CNV gain 19592680
nsv828128 CNV loss 20364138
nsv833564 CNV loss 17160897
nsv952388 CNV deletion 24416366
nsv952389 CNV deletion 24416366

Variation tolerance for AATK Gene

Gene Damage Index Score: 9.14; 87.82% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for AATK Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AATK Gene

Disorders for AATK Gene

MalaCards: The human disease database

(1) MalaCards diseases for AATK Gene - From: GeneCards

Disorder Aliases PubMed IDs
  • neuroblastoma 1
- elite association - COSMIC cancer census association via MalaCards
Search AATK in MalaCards View complete list of genes associated with diseases

Relevant External Links for AATK

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with AATK: view

No data available for UniProtKB/Swiss-Prot and Genatlas for AATK Gene

Publications for AATK Gene

  1. Apoptosis-associated tyrosine kinase is a Cdk5 activator p35 binding protein. (PMID: 14521924) Honma N. … Hisanaga S. (Biochem. Biophys. Res. Commun. 2003) 3 4 22 64
  2. A novel kinase, AATYK induces and promotes neuronal differentiation in a human neuroblastoma (SH-SY5Y) cell line. (PMID: 10837911) Raghunath M. … Damodar Reddy C. (Brain Res. Mol. Brain Res. 2000) 3 4 22 64
  3. Chromosomal assignment of a human apoptosis-associated tyrosine kinase gene on chromosome 17q25.3 by somatic hybrid analysis and fluorescence in situ hybridization. (PMID: 10083745) Seki N. … Saito T. (J. Hum. Genet. 1999) 2 3 22 64
  4. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9734811) Ishikawa K. … Ohara O. (DNA Res. 1998) 2 3 4 64
  5. LMTK1/AATYK1 is a novel regulator of axonal outgrowth that acts via Rab11 in a Cdk5-dependent manner. (PMID: 22573681) Takano T. … Hisanaga S. (J. Neurosci. 2012) 2 3 64

Products for AATK Gene

Sources for AATK Gene

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