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AATK Gene

protein-coding   GIFtS: 59

GC17M076707
apoptosis-associated tyrosine kinase
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
AATYK 1, 2, 3, 5
AATYK1 1, 2
EC 2.7.11.1 3
KIAA0641 1, 2, 3
LMR1 1, 2, 3
LMTK1 1, 2, 3
p35BP 2, 3
Descriptions
Brain apoptosis-associated tyrosine kinase 3
CDK5-binding protein 2, 3
Lemur tyrosine kinase 1 2, 3
apoptosis-associated tyrosine kinase 2, 3
p35-binding protein 2, 3
serine/threonine-protein kinase LMTK1 2
External Ids
HGNC: 211
Entrez Gene: 96252
UniProtKB: Q6ZMQ83
Ensembl: ENSG000001814097
Search outside databases for aliases for AATK gene

Previous GC identifers: GC17U990147 GC17M082453 GC17M079653 GC17M079791

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for AATK:
The protein encoded by this gene contains a tyrosine kinase domain at the N-terminus and a
proline-rich domain at the C-terminus. This gene is induced during apoptosis, and expression of
this gene may be a necessary pre-requisite for the induction of growth arrest and/or apoptosis of
myeloid precursor cells. This gene has been shown to produce neuronal differentiation in a
neuroblastoma cell line. [provided by RefSeq]

UniProtKB/Swiss-Prot: LMTK1_HUMAN, Q6ZMQ8
Function: May be involved in neuronal differentiation

Gene Wiki entry for AATK

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the AATK gene  

Entrez Gene cytogenetic band: 17q25.3   Ensembl cytogenetic band:  17q25.3   HGNC cytogenetic band: 17q25.3

AATK Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M076707:     (about GC identifiers)

Start:
76,705,160 bp from pter
End:
76,754,467 bp from pter
Size:
49,308 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000017.9  NT_024871.11  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: LMTK1_HUMAN, Q6ZMQ8 (See protein sequence)
Recommended Name: Serine/threonine-protein kinase LMTK1  
Size: 1374 amino acids; 144569 Da
Subunit: Interacts with CDK5
Subcellular location: Membrane; Single-pass type I membrane protein (By similarity). Cytoplasm.
Cytoplasm, perinuclear region. Note=Predominantly perinuclear
Secondary accessions: O75136 Q6ZN31 Q86X28
Alternative splicing: 3 isoforms:  Q6ZMQ8-1   Q6ZMQ8-2   Q6ZMQ8-3   

Post-translational modifications:

  • Autophosphorylated. Phosphorylated by CDK51
  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_001073864.2  

    ENSEMBL proteins: 
    ENSP00000324196 ENSP00000363924 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (AATK)
    Human Recombinant Proteins from Abnova (AATK)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    4 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737 cytoplasm IEA--
    GO:0005739 mitochondrion IDA18029348
    GO:0016020 membrane IEA--
    GO:0016021 integral to membrane IEA--
    About this table

    Antibodies for AATK: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for AATK
    R&D Systems Antibodies for AATK
    Antibodies from Abcam (AATK), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (AATK)
    Novus Biologicals Antibodies for AATK

    Assays for AATK: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    4 InterPro domains/families:
     IPR017441 Protein_kinase_ATP_BS
     IPR000719 Prot_kinase_core
     IPR008266 Tyr_pkinase_AS
     IPR001245 Tyr_pkinase


       GeneDecks  AATK for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q6ZMQ8

    ProtoNet protein and cluster: Q6ZMQ8

    1 Blocks protein family: IPB008266 Tyrosine protein kinase

    UniProtKB/Swiss-Prot: LMTK1_HUMAN, Q6ZMQ8
    Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family
    Similarity: Contains 1 protein kinase domain

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (AATK)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (AATK)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_001080395

                  Applied Biosystems Silencer® siRNAs for AATK

                  Sigma-Aldrich siRNA and siRNA Panels for AATK  
                         Sigma-Aldrich shRNA Panels and shRNA for AATK  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Browse Clone Ranger at Invitrogen for clones
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_001080395
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_001080395
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_001080395 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_001080395

    UniProtKB/Swiss-Prot: LMTK1_HUMAN, Q6ZMQ8
    Function: May be involved in neuronal differentiation
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Induction: Up-regulated during apoptosis
    Enzyme Number (IUBMB): EC 2.7.11.1 

    Genatlas biochemistry entry for AATK:
    apoptosis associated tyrosine-kinase (AATYK),murine homolog

    5/6 Gene Ontology (GO) molecular function terms (links to tree view) (see all 6 ):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166 nucleotide binding IEA--
    GO:0004674 protein serine/threonine kinase activity IEA--
    GO:0004713 protein tyrosine kinase activity IEA--
    GO:0005515 protein binding IPI14521924
    GO:0005524 ATP binding IEA--
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


    2 Cell Signaling Technology (CST) Pathways for AATK: 
     Translational Control: Regulation of eIF4E and p70 S6 Kinase
     Protein Acetylation

       GeneDecks  AATK for the pathways selected above  
    About GeneDecksing

     Gene Network CentralTM Interacting Genes and Proteins Network for  AATK 


    3 Interacting proteins for AATK (ENSP000003241963 Q6ZMQ81) via UniProtKB, MINT, and/or STRING
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDK5Q005351EBI-2008441, EBI-1041567
    CDK5R1Q150781EBI-2008436, EBI-746189
    STK39ENSP000003482783STRING (score=.716)
    About this table

    1 Gene Ontology (GO) biological process term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468 protein amino acid phosphorylation IEA--
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for AATK

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (AATK)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (AATK)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_001080395

                  Sigma-Aldrich siRNA and siRNA Panels for AATK  
                         Sigma-Aldrich shRNA Panels and shRNA for AATK  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_001080395  

    REFSEQ mRNAs for AATK gene: 

    NM_001080395.2   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_001080395  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_001080395
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_001080395
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_001080395 

    Additional cDNA sequence: 

    AB014541.2 AK094931.1 AK131395.1 AK131529.1 AK309099.1 BC047378.1 

    9 DOTS entries:

    DT.120937425  DT.97759993  DT.100038796  DT.102841857  DT.120937373  DT.91823357  DT.92444968  DT.95296286 
    DT.100885087 

    highest scoring ESTs for AATK:

    AA322346 AK094931 AL120105 AL120847 AL135028 BC047378 BF306070 BG827921 BG899690 BG911396 

    Unigene Cluster for AATK:

    Apoptosis-associated tyrosine kinase
    Hs.514575  [show with all ESTs]
    Unigene Representative Sequence: NM_001080395


    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for AATK (see all 7 )

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b
    SP1:                                                                                                                              
    SP2:                                                                          -                                                   
    SP3:                                                                                                  -                           
    SP4:                                                                                                  -                           
    SP5:                                                                                                                              

    About this scheme

    ECgene alternative splicing isoforms for AATK

    2 Ensembl transcripts including schematic representations:
    ENST00000326724  ENST00000374792  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    AATK expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for AATK

    1 / 2 / 3

    3 probe-sets matching AATK gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    34907_at2, 3 U95-A 1 1.00 1.00 1.00 1.00 AB014541 0.60 0.75 0.68 1

    205986_at2, 3 U133-A 1 1.00 1.00 -- -- NM_004920 0.20 1.00 0.72 1

    205986_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    GeneDecks  AATK for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: CCCCGCAGTC

    SOURCE GeneReport for Unigene cluster: Hs.514575

    Expression variation in blood from EXPOLDB for AATK

    UniProtKB/Swiss-Prot: LMTK1_HUMAN, Q6ZMQ8
    Tissue specificity: Expressed in brain

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for AATK gene from 4 species
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    cow
    (Bos taurus)
    AATK1   -- apoptosis-associated tyrosine kinase 80.82(n)
    77.77(a)
    511515  XM_588863.3  XP_588863.3 
    rat
    (Rattus norvegicus)
    Aatk1   -- apoptosis-associated tyrosine kinase 77.6(n)
    74.67(a)
    690853  XM_001075880.1  XP_001075880.1 
    mouse
    (Mus musculus)
    Aatk1, 5 115
    apoptosis-associated tyrosine kinase1, 5 77.37(n)1
    74.34(a)1
    113021  NM_007377.31  NP_031403.21 
     AB0932535  AB2888715  (see all 16)
    zebrafish
    (Danio rerio)
    LOC1001497931   -- similar to Serine/threonine-protein kinase LMTK1 (Lemur more 59.08(n)
    57.83(a)
    100149793  XM_001920139.1  XP_001920174.1 
    About this table        Species with no ortholog for AATK

    ENSEMBL Gene Tree for AATK
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for AATK gene
    LMTK22  LMTK32  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/146 NCBI SNPs in AATK are shown (see all 146 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 50)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 17 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs116581451,2
    A,C76722913(+) CAGTGC/TGGTGA 1 -- ng310--------
    --
    rs75036041,2
    A,C76710224(+) GTGGCA/CGCCCG 1 G/C mis1 ese30--------
    rs118683831,2
    C76722450(+) CAGAGA/CCCCCG 1 -- ng310--------
    --
    rs80820161,2
    C76707870(+) CGGGCA/GTGGGC 1 T/M mis1 ese30--------
    rs49693971,2
    C76722736(+) CCACGA/GCAGCT 1 -- ng310--------
    rs118683761,2
    C76722358(+) GAATTC/TGGAGG 1 -- ng310--------
    rs118710621,2
    A,C,F,H76716925(+) ACGTCT/CGTGGA 1 T/T syn1 ese36Minor allele frequency- C:0.08EU EA WA 588
    rs80739041,2
    A,C,F,H76709739(+) GCCTCA/GGCCGT 1 A/A syn1 ese34Minor allele frequency- G:0.16EU EA WA 406
    rs49693941,2
    A,C,F,H76712771(+) CGGCCT/CGACCT 1 -- int14Minor allele frequency- C:0.37EU EA WA 416
    rs80731821,2
    A,C,F,H76719357(+) GCCCCC/TACTCC 1 -- int14Minor allele frequency- T:0.48EU EA WA 414
    About this table

    HapMap Linkage Disequilibrium images for AATK (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 605276

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/16 PubMed articles for AATK gene (see all 16 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 9625 HGNC: 21 Ensembl:ENSG00000181409 euGenes: HUgn9625 ECgene: AATK
    H-InvDB: AATK
    (According to HUGE)
    About This Section

    HUGE: KIAA0641
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

    NameDescription
    CGP resequencing studieshttp://www.sanger.ac.uk/perl/genetics/CGP/cgp_viewer?action=gene&ln=AATK
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for AATK:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



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     Predesigned and custom siRNAs for AATK Antibodies for AATK
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for AATK Browse small molecules at Sigma-Aldrich
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     Antibodies for AATK

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