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Aliases for AATK Gene

Aliases for AATK Gene

  • Apoptosis-Associated Tyrosine Kinase 2 3 4
  • Lemur Tyrosine Kinase 1 2 3 4
  • AATYK 3 4 6
  • Brain Apoptosis-Associated Tyrosine Kinase 3 4
  • CDK5-Binding Protein 3 4
  • P35-Binding Protein 3 4
  • EC 4 63
  • LMTK1 3 4
  • P35BP 3 4
  • LMR1 3 4
  • Protein Phosphatase 1, Regulatory Subunit 77 3
  • Serine/Threonine-Protein Kinase LMTK1 3
  • Protein Phosphatase 1 2
  • Regulatory Subunit 77 2
  • EC 2.7.11 63
  • KIAA0641 4
  • PPP1R77 3
  • AATYK1 3

External Ids for AATK Gene

Previous GeneCards Identifiers for AATK Gene

  • GC17U990147
  • GC17M082453
  • GC17M079653
  • GC17M079791
  • GC17M076707
  • GC17M079091

Summaries for AATK Gene

Entrez Gene Summary for AATK Gene

  • The protein encoded by this gene contains a tyrosine kinase domain at the N-terminus and a proline-rich domain at the C-terminus. This gene is induced during apoptosis, and expression of this gene may be a necessary pre-requisite for the induction of growth arrest and/or apoptosis of myeloid precursor cells. This gene has been shown to produce neuronal differentiation in a neuroblastoma cell line. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2011]

GeneCards Summary for AATK Gene

AATK (Apoptosis-Associated Tyrosine Kinase) is a Protein Coding gene. Diseases associated with AATK include neuroblastoma. GO annotations related to this gene include protein serine/threonine kinase activity and protein tyrosine kinase activity. An important paralog of this gene is LMTK2.

UniProtKB/Swiss-Prot for AATK Gene

  • May be involved in neuronal differentiation.

Gene Wiki entry for AATK Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AATK Gene

Genomics for AATK Gene

Regulatory Elements for AATK Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for AATK Gene

81,117,295 bp from pter
81,166,077 bp from pter
48,783 bases
Minus strand

Genomic View for AATK Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for AATK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AATK Gene

Proteins for AATK Gene

  • Protein details for AATK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Serine/threonine-protein kinase LMTK1
    Protein Accession:
    Secondary Accessions:
    • O75136
    • Q6ZN31
    • Q86X28

    Protein attributes for AATK Gene

    1374 amino acids
    Molecular mass:
    144569 Da
    Quaternary structure:
    • Interacts with CDK5.

    Alternative splice isoforms for AATK Gene


neXtProt entry for AATK Gene

Proteomics data for AATK Gene at MOPED

Selected DME Specific Peptides for AATK Gene

Post-translational modifications for AATK Gene

Other Protein References for AATK Gene

Domains for AATK Gene

Suggested Antigen Peptide Sequences for AATK Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. Tyr protein kinase family.
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. Tyr protein kinase family.
genes like me logo Genes that share domains with AATK: view

Function for AATK Gene

Molecular function for AATK Gene

GENATLAS Biochemistry:
apoptosis associated tyrosine-kinase (AATYK),murine homolog
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot Function:
May be involved in neuronal differentiation.
UniProtKB/Swiss-Prot Induction:
Up-regulated during apoptosis

Enzyme Numbers (IUBMB) for AATK Gene

Gene Ontology (GO) - Molecular Function for AATK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0004713 protein tyrosine kinase activity IEA --
GO:0005515 protein binding IPI 14521924
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with AATK: view

Phenotypes for AATK Gene

MGI mutant phenotypes for AATK:
inferred from 1 alleles
GenomeRNAi human phenotypes for AATK:
genes like me logo Genes that share phenotypes with AATK: view

Animal Models for AATK Gene

MGI Knock Outs for AATK:

Animal Model Products

miRNA for AATK Gene

miRTarBase miRNAs that target AATK

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for AATK

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for AATK Gene

Localization for AATK Gene

Subcellular locations from UniProtKB/Swiss-Prot for AATK Gene

Membrane; Single-pass type I membrane protein. Cytoplasm. Cytoplasm, perinuclear region. Note=Predominantly perinuclear.

Subcellular locations from

Jensen Localization Image for AATK Gene COMPARTMENTS Subcellular localization image for AATK gene
Compartment Confidence
mitochondrion 4
plasma membrane 3
cytosol 2
endosome 2
cytoskeleton 1
extracellular 1
lysosome 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for AATK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0016021 integral component of membrane IEA --
GO:0044295 axonal growth cone IEA --
GO:0048471 perinuclear region of cytoplasm IEA --
GO:0055037 recycling endosome IEA --
genes like me logo Genes that share ontologies with AATK: view

Pathways for AATK Gene

SuperPathways for AATK Gene

No Data Available

Gene Ontology (GO) - Biological Process for AATK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation --
GO:0006915 apoptotic process --
GO:0007420 brain development IEA --
GO:0030517 negative regulation of axon extension IEA --
GO:0032482 Rab protein signal transduction IEA --
genes like me logo Genes that share ontologies with AATK: view

No data available for Pathways by source for AATK Gene

Transcripts for AATK Gene

mRNA/cDNA for AATK Gene

(6) Additional mRNA sequences :
(12) REFSEQ mRNAs :
(10) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for AATK Gene

Apoptosis-associated tyrosine kinase:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for AATK

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for AATK Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b
SP2: -
SP3: -
SP4: -

Relevant External Links for AATK Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for AATK Gene

mRNA expression in normal human tissues for AATK Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for AATK Gene

This gene is overexpressed in Nerve - Tibial (8.4) and Brain - Spinal cord (cervical c-1) (5.0).

Protein differential expression in normal tissues for AATK Gene

This gene is overexpressed in Ovary (35.1), Adipocyte (23.6), and NK cells (10.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for AATK Gene

SOURCE GeneReport for Unigene cluster for AATK Gene Hs.514575

mRNA Expression by UniProt/SwissProt for AATK Gene

Tissue specificity: Expressed in brain.
genes like me logo Genes that share expressions with AATK: view

Expression partners for AATK Gene

* - Elite partner

Primer Products

In Situ Assay Products

Orthologs for AATK Gene

This gene was present in the common ancestor of chordates.

Orthologs for AATK Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia AATK 35
  • 81.47 (n)
  • 78.67 (a)
  • 72 (a)
(Canis familiaris)
Mammalia AATK 35
  • 83.36 (n)
  • 81.55 (a)
  • 71 (a)
(Mus musculus)
Mammalia Aatk 35
  • 77.8 (n)
  • 75.13 (a)
Aatk 16
Aatk 36
  • 69 (a)
(Pan troglodytes)
Mammalia AATK 35
  • 95.69 (n)
  • 94.49 (a)
  • 97 (a)
(Rattus norvegicus)
Mammalia Aatk 35
  • 78.05 (n)
  • 75.52 (a)
(Monodelphis domestica)
Mammalia AATK 36
  • 54 (a)
(Gallus gallus)
Aves AATK 35
  • 68.58 (n)
  • 62.94 (a)
  • 48 (a)
(Anolis carolinensis)
Reptilia AATK 36
  • 50 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia aatk 35
  • 56.87 (n)
  • 54.95 (a)
(Danio rerio)
Actinopterygii aatkb 35
  • 60.55 (n)
  • 59.79 (a)
aatka 36
  • 37 (a)
aatkb 36
  • 36 (a)
Species with no ortholog for AATK:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for AATK Gene

Gene Tree for AATK (if available)
Gene Tree for AATK (if available)

Paralogs for AATK Gene

Paralogs for AATK Gene

(4) SIMAP similar genes for AATK Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with AATK: view

Variants for AATK Gene

Sequence variations from dbSNP and Humsavar for AATK Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs79837934 -- 81,150,188(+) GTGGT(A/G)GTTTC intron-variant
rs80179796 -- 81,160,997(+) GCGCC(C/G)TGGAG intron-variant, upstream-variant-2KB
rs111072851 -- 81,138,465(+) CACAC(A/C)CACCC intron-variant
rs112071754 -- 81,150,785(+) GGCCT(C/T)GGCAG intron-variant
rs112057380 -- 81,162,070(+) GCCTC(A/G)CACCC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for AATK Gene

Variant ID Type Subtype PubMed ID
esv26223 CNV Gain+Loss 19812545
nsv828128 CNV Loss 20364138
dgv3304n71 CNV Loss 21882294
nsv909000 CNV Loss 21882294
dgv3308n71 CNV Loss 21882294
nsv833564 CNV Loss 17160897
nsv909021 CNV Loss 21882294
nsv470619 CNV Loss 18288195
dgv3310n71 CNV Loss 21882294
dgv3311n71 CNV Loss 21882294
dgv3312n71 CNV Loss 21882294
dgv3313n71 CNV Loss 21882294
nsv909037 CNV Loss 21882294
dgv3314n71 CNV Loss 21882294
nsv523417 CNV Gain 19592680
nsv909047 CNV Gain 21882294
dgv3315n71 CNV Loss 21882294
esv2716425 CNV Deletion 23290073
esv2716426 CNV Deletion 23290073
esv2716427 CNV Deletion 23290073
dgv3316n71 CNV Loss 21882294
nsv909052 CNV Loss 21882294
dgv46n68 CNV Loss 17160897
esv1011110 CNV Insertion 20482838
esv2716428 CNV Deletion 23290073
esv2716430 CNV Deletion 23290073
esv2716431 CNV Deletion 23290073
esv271790 CNV Insertion 20981092
dgv3317n71 CNV Loss 21882294
dgv1003e1 CNV Complex 17122850
nsv428351 CNV Gain 18775914
esv2716432 CNV Deletion 23290073
esv2278259 CNV Deletion 18987734
esv2668695 CNV Deletion 23128226
esv2716433 CNV Deletion 23290073
esv2148507 CNV Deletion 18987734
esv2716434 CNV Deletion 23290073
esv1314431 CNV Deletion 17803354
dgv3318n71 CNV Loss 21882294

Relevant External Links for AATK Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AATK Gene

Disorders for AATK Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for AATK Gene in MalaCards »

(1) Disease for AATK Gene

Relevant External Links for AATK

Genetic Association Database (GAD)
genes like me logo Genes that share disorders with AATK: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for AATK Gene

Publications for AATK Gene

  1. Chromosomal assignment of a human apoptosis-associated tyrosine kinase gene on chromosome 17q25.3 by somatic hybrid analysis and fluorescence in situ hybridization. (PMID: 10083745) Seki N. … Saito T. (J. Hum. Genet. 1999) 2 3 23
  2. A novel kinase, AATYK induces and promotes neuronal differentiation in a human neuroblastoma (SH-SY5Y) cell line. (PMID: 10837911) Raghunath M. … Damodar Reddy C. (Brain Res. Mol. Brain Res. 2000) 3 4 23
  3. Apoptosis-associated tyrosine kinase is a Cdk5 activator p35 binding protein. (PMID: 14521924) Honma N. … Hisanaga S. (Biochem. Biophys. Res. Commun. 2003) 3 4 23
  4. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9734811) Ishikawa K. … Ohara O. (DNA Res. 1998) 2 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for AATK Gene

Sources for AATK Gene

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