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AATK Gene

protein-coding   GIFtS: 56
GCID: GC17M079091

Apoptosis-Associated Tyrosine Kinase

  See AATK-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Apoptosis-Associated Tyrosine Kinase1 2 3     P35-Binding Protein2 3
Lemur Tyrosine Kinase 11 2 3     p35BP2 3
AATYK2 3 5     EC 2.7.11.13 8
Brain Apoptosis-Associated Tyrosine Kinase2 3     AATYK12
LMR12 3     Serine/Threonine-Protein Kinase LMTK12
LMTK12 3     KIAA06413
CDK5-Binding Protein2 3     EC 2.7.118

External Ids:    HGNC: 211   Entrez Gene: 96252   Ensembl: ENSG000001814097   OMIM: 6052765   UniProtKB: Q6ZMQ83   
ORGUL members:         

Export aliases for AATK gene to outside databases

Previous GC identifers: GC17U990147 GC17M082453 GC17M079653 GC17M079791 GC17M076707


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for AATK Gene:
The protein encoded by this gene contains a tyrosine kinase domain at the N-terminus and a proline-rich domain at
the C-terminus. This gene is induced during apoptosis, and expression of this gene may be a necessary
pre-requisite for the induction of growth arrest and/or apoptosis of myeloid precursor cells. This gene has been
shown to produce neuronal differentiation in a neuroblastoma cell line. Two transcript variants encoding
different isoforms have been found for this gene. (provided by RefSeq, Jun 2011)

GeneCards Summary for AATK Gene:
AATK (apoptosis-associated tyrosine kinase) is a protein-coding gene. Diseases associated with AATK include neuroblastoma. GO annotations related to this gene include protein serine/threonine kinase activity and protein tyrosine kinase activity. An important paralog of this gene is LMTK2.

UniProtKB/Swiss-Prot: LMTK1_HUMAN, Q6ZMQ8
Function: May be involved in neuronal differentiation

Gene Wiki entry for AATK Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NT_010783.16  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the AATK gene promoter:
         SRF   NCX/Ncx   LCR-F1   YY1   AREB6   POU2F1   POU2F1b   POU2F1a   POU2F1c   ATF   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for AATK

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat AATK


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q25.3   Ensembl cytogenetic band:  17q25.3   HGNC cytogenetic band: 17q25.3

AATK Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AATK gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M079091:  view genomic region     (about GC identifiers)

Start:
79,091,095 bp from pter      End:
79,139,877 bp from pter
Size:
48,783 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: LMTK1_HUMAN, Q6ZMQ8 (See protein sequence)
Recommended Name: Serine/threonine-protein kinase LMTK1  
Size: 1374 amino acids; 144569 Da
Subunit: Interacts with CDK5
Secondary accessions: O75136 Q6ZN31 Q86X28
Alternative splicing: 3 isoforms:  Q6ZMQ8-1   Q6ZMQ8-2   Q6ZMQ8-3   

Explore the universe of human proteins at neXtProt for AATK: NX_Q6ZMQ8

Explore proteomics data for AATK at MOPED

Post-translational modifications: 

  • Autophosphorylated. Phosphorylated by CDK51
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • 2 DME Specific Peptides for AATK (Q6ZMQ8)
     CGVLHLH  HSDLALRNC 


    See AATK Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001073864.2  NP_004911.2  

    ENSEMBL proteins: 
     ENSP00000324196   ENSP00000460986   ENSP00000363924   ENSP00000398796   ENSP00000460202  

    AATK Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for AATK

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: apoptosis-associated tyrosine kinase
    Lmr family

    5 InterPro protein domains:
     IPR017441 Protein_kinase_ATP_BS
     IPR001245 Ser-Thr/Tyr_kinase_cat_dom
     IPR011009 Kinase-like_dom
     IPR000719 Prot_kinase_dom
     IPR008266 Tyr_kinase_AS

    Graphical View of Domain Structure for InterPro Entry Q6ZMQ8

    ProtoNet protein and cluster: Q6ZMQ8

    1 Blocks protein domain: IPB008266 Tyrosine protein kinase

    UniProtKB/Swiss-Prot: LMTK1_HUMAN, Q6ZMQ8
    Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family
    Similarity: Contains 1 protein kinase domain


    Find genes that share domains with AATK           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LMTK1_HUMAN, Q6ZMQ8
    Function: May be involved in neuronal differentiation
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Induction: Up-regulated during apoptosis

         Genatlas biochemistry entry for AATK:
    apoptosis associated tyrosine-kinase (AATYK),murine homolog

         Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity IEA--
    GO:0004713protein tyrosine kinase activity IEA--
    GO:0005515protein binding IPI14521924
    GO:0005524ATP binding IEA--
         
    Find genes that share ontologies with AATK           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for AATK:
     Decreased focal adhesion (FA)   Decreased substrate adherent c 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Aatk):
     nervous system 

    Find genes that share phenotypes with AATK           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Aatktm1Shhi for AATK

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for AATK
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for AATK
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for AATK

    miRNA
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    miRTarBase miRNAs that target AATK:
    hsa-mir-335-5p (MIRT018823)

    Block miRNA regulation of human, mouse, rat AATK using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate AATK (see all 28):
    hsa-miR-1226 hsa-miR-520d-5p hsa-miR-15a hsa-miR-25 hsa-miR-767-5p hsa-miR-1271 hsa-miR-503 hsa-miR-371-5p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Browse Sino Biological Human cDNA Clones
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    LMTK1_HUMAN, Q6ZMQ8: Membrane; Single-pass type I membrane protein (By similarity). Cytoplasm. Cytoplasm,
    perinuclear region. Note=Predominantly perinuclear
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion4
    plasma membrane3
    cytosol2
    endosome2
    cytoskeleton1
    extracellular1
    lysosome1
    nucleus1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion ----
    GO:0005783endoplasmic reticulum IEA--
    GO:0016021integral component of membrane IEA--
    GO:0044295axonal growth cone IEA--
    GO:0048471perinuclear region of cytoplasm IEA--

    Find genes that share ontologies with AATK           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for AATK
    Interactions:

        GeneGlobe Interaction Network for AATK

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5 Interacting proteins for AATK (Q6ZMQ81, 3 ENSP000003241964) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDK5R1Q150781, 3, ENSP000003184864EBI-2008441,EBI-746189 I2D: score=1 STRING: ENSP00000318486
    STK39Q9UEW83, ENSP000003482784I2D: score=1 STRING: ENSP00000348278
    CDK5ENSP000002975184STRING: ENSP00000297518
    TSC1ENSP000002985524STRING: ENSP00000298552
    PPP1CAENSP000003260314STRING: ENSP00000326031
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation ----
    GO:0006915apoptotic process ----
    GO:0007420brain development IEA--
    GO:0030517negative regulation of axon extension IEA--
    GO:0032482Rab protein signal transduction IEA--

    Find genes that share ontologies with AATK           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for AATK (LMTK1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for AATK gene (2 alternative transcripts): 
    NM_001080395.2  NM_004920.2  

    Unigene Cluster for AATK:

    Apoptosis-associated tyrosine kinase
    Hs.514575  [show with all ESTs]
    Unigene Representative Sequence: NM_001080395
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000326724(uc010dhz.3 uc010dia.3) ENST00000570932 ENST00000374792
    ENST00000417379(uc021ueu.1) ENST00000573469 ENST00000573441 ENST00000572339
    ENST00000576053 ENST00000575363 ENST00000572798
    miRNA
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    Block miRNA regulation of human, mouse, rat AATK using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate AATK (see all 28):
    hsa-miR-1226 hsa-miR-520d-5p hsa-miR-15a hsa-miR-25 hsa-miR-767-5p hsa-miR-1271 hsa-miR-503 hsa-miR-371-5p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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      QuantiTect SYBR Green Assays in human, mouse, rat AATK
      QuantiFast Probe-based Assays in human, mouse, rat AATK

    Additional mRNA sequence: 

    AB014541.2 AK094931.1 AK131395.1 AK131529.1 AK309099.1 BC047378.1 

    9 DOTS entries:

    DT.120937425  DT.97759993  DT.100038796  DT.102841857  DT.120937373  DT.91823357  DT.92444968  DT.95296286 
    DT.100885087 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for AATK (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b
    SP1:                                                                                                                              
    SP2:                                                                          -                                                   
    SP3:                                                                                                  -                           
    SP4:                                                                                                  -                           
    SP5:                                                                                                                              


    ECgene alternative splicing isoforms for AATK

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    AATK expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCCGCAGTC
    AATK Expression
    About this image


    AATK expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Peripheral Nervous System (Nervous System)    fully expand to see all 3 entries
             Pro-myelinating Schwann Cells Peripheral Nerve Domain
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Granulocytes Peripheral Blood
    AATK Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    AATK Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.514575

    UniProtKB/Swiss-Prot: LMTK1_HUMAN, Q6ZMQ8
    Tissue specificity: Expressed in brain

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AATK

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for AATK gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Aatk1 , 5 apoptosis-associated tyrosine kinase1, 5 77.8(n)1
    75.13(a)1
      11 (83.96 cM)5
    113021  NM_001198785.11  NP_001185714.11 
     1200073135 
    chicken
    (Gallus gallus)
    Aves AATK1 apoptosis-associated tyrosine kinase 68.58(n)
    62.94(a)
      422076  XM_420079.4  XP_420079.4 
    lizard
    (Anolis carolinensis)
    Reptilia AATK6
    apoptosis-associated tyrosine kinase
    50(a)
    1 ↔ 1
    2(99486276-99509584)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia aatk1 apoptosis-associated tyrosine kinase 56.87(n)
    54.95(a)
      101730552  XM_004918565.1  XP_004918622.1 
    zebrafish
    (Danio rerio)
    Actinopterygii aatkb1 apoptosis-associated tyrosine kinase b 60.55(n)
    59.79(a)
      555739  XM_678332.6  XP_683424.6 


    ENSEMBL Gene Tree for AATK (if available)
    TreeFam Gene Tree for AATK (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for AATK gene
    LMTK22  LMTK32  
    4 SIMAP similar genes for AATK using alignment to 4 protein entries:     LMTK1_HUMAN (see all proteins):
    BTK kinase deficient isoform 6    DKFZp434L0319    FES    tec

    Find genes that share paralogs with AATK           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for AATK (see all 1118)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0326814
    An ovarian mucinous carcinoma sample4--see VAR_0326812 M V mis40--------
    VAR_0326804
    A lung adenocarcinoma sample4--see VAR_0326802 L V mis40--------
    VAR_0326794
    An ovarian mucinous carcinoma sample4--see VAR_0326792 S F mis40--------
    rs728541671,2
    C--79091748(+) GGGAAA/GAGGCT 2 -- ut310--------
    rs1908944771,2
    --79091774(+) GTCTCA/GGGGCC 2 -- ut310--------
    rs72207211,2
    C--79091883(+) GGGGCC/TGCCGT 2 -- ut31 ese33Minor allele frequency- T:0.09WA NA 240
    rs774084801,2
    C--79091904(+) ACTGGC/TCCCTT 2 -- ut310--------
    rs728541691,2
    --79092017(+) CATGGC/TCGATC 2 -- ut310--------
    rs1158984001,2
    C,F--79092019(+) TGGCCG/CATCTA 2 -- ut311Minor allele frequency- C:0.03WA 118
    rs1839215571,2
    --79092024(+) GATCTA/GCCATC 2 -- ut310--------

    HapMap Linkage Disequilibrium report for AATK (79091095 - 79139877 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for AATK (see all 39):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2716434CNV Deletion23290073
    esv2716433CNV Deletion23290073
    esv2278259CNV Deletion18987734
    esv2716431CNV Deletion23290073
    esv2716427CNV Deletion23290073
    esv1314431CNV Deletion17803354
    esv2716428CNV Deletion23290073
    esv2148507CNV Deletion18987734
    esv2716430CNV Deletion23290073
    esv2716425CNV Deletion23290073

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605276    OMIM disorders: --

    1 disease for AATK:    
    About MalaCards
    neuroblastoma


    Find genes that share disorders with AATK           About GenesLikeMe

    Genetic Association Database (GAD): AATK

    Export disorders for AATK gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for AATK gene, integrated from 10 sources (see all 20):
    (articles sorted by number of sources associating them with AATK)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9734811)1, 2, 3 Ishikawa K.... Ohara O. (DNA Res. 1998)
    2. Apoptosis-associated tyrosine kinase is a Cdk5 activator p35 binding protein. (PubMed id 14521924)1, 2, 9 Honma N....Hisanaga S. (Biochem. Biophys. Res. Commun. 2003)
    3. Chromosomal assignment of a human apoptosis-associated tyrosine kinase gene on chromosome 17q25.3 by somatic hybrid analysis and fluorescence in situ hybridization. (PubMed id 10083745)1, 3, 9 Seki N....Saito T. (J. Hum. Genet. 1999)
    4. A novel kinase, AATYK induces and promotes neuronal differentiation in a human neuroblastoma (SH-SY5Y) cell line. (PubMed id 10837911)1, 2, 9 Raghunath M.... Damodar Reddy C. (Brain Res. Mol. Brain Res. 2000)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (DNA Res. 2002)
    8. Protein phosphatase 1I^ isoforms linked interactions in the brain. (PubMed id 23080069)1 Esteves S.L....da Cruz e Silva E.F. (J. Mol. Neurosci. 2013)
    9. Protein phosphatase 1I+ interacting proteins in the human brain. (PubMed id 22321011)1 Esteves S.L....da Cruz e Silva E.F. (OMICS 2012)
    10. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)1 Comuzzie A.G....Butte N.F. (PLoS ONE 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 9625 HGNC: 21 Ensembl:ENSG00000181409 euGenes: HUgn9625 ECgene: AATK
    H-InvDB: AATK

    (According to HUGE)
    About This Section

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    HUGE: KIAA0641

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for AATK Pharmacogenomics, SNPs, Pathways
    CGP resequencing studieshttp://www.sanger.ac.uk/perl/genetics/CGP/cgp_viewer?action=gene&ln=AATK

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for AATK gene:
    Search GeneIP for patents involving AATK

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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