Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

AATK Gene

protein-coding   GIFtS: 54
GCID: GC17M079091

Apoptosis-Associated Tyrosine Kinase

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Apoptosis-Associated Tyrosine Kinase1 2 3     P35-Binding Protein2 3
Lemur Tyrosine Kinase 11 2 3     p35BP2 3
AATYK2 3 5     EC 2.7.11.13 8
Brain Apoptosis-Associated Tyrosine Kinase2 3     AATYK12
LMR12 3     Serine/Threonine-Protein Kinase LMTK12
LMTK12 3     KIAA06413
CDK5-Binding Protein2 3     EC 2.7.118

External Ids:    HGNC: 211   Entrez Gene: 96252   Ensembl: ENSG000001814097   OMIM: 6052765   UniProtKB: Q6ZMQ83   

Export aliases for AATK gene to outside databases

Previous GC identifers: GC17U990147 GC17M082453 GC17M079653 GC17M079791 GC17M076707


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for AATK Gene:
The protein encoded by this gene contains a tyrosine kinase domain at the N-terminus and a proline-rich domain at
the C-terminus. This gene is induced during apoptosis, and expression of this gene may be a necessary
pre-requisite for the induction of growth arrest and/or apoptosis of myeloid precursor cells. This gene has been
shown to produce neuronal differentiation in a neuroblastoma cell line. Two transcript variants encoding
different isoforms have been found for this gene. (provided by RefSeq, Jun 2011)

GeneCards Summary for AATK Gene: 
AATK (apoptosis-associated tyrosine kinase) is a protein-coding gene. Diseases associated with AATK include moyamoya disease, and neuroblastoma. GO annotations related to this gene include protein serine/threonine kinase activity and protein tyrosine kinase activity. An important paralog of this gene is LMTK2.

UniProtKB/Swiss-Prot: LMTK1_HUMAN, Q6ZMQ8
Function: May be involved in neuronal differentiation

Gene Wiki entry for AATK Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NT_010783.15  NC_018928.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the AATK gene promoter:
         SRF   NCX/Ncx   LCR-F1   YY1   AREB6   POU2F1   POU2F1b   POU2F1a   POU2F1c   ATF   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for AATK

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AATK


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q25.3   Ensembl cytogenetic band:  17q25.3   HGNC cytogenetic band: 17q25.3

AATK Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AATK gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M079091:  view genomic region     (about GC identifiers)

Start:
79,091,095 bp from pter      End:
79,139,877 bp from pter
Size:
48,783 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: LMTK1_HUMAN, Q6ZMQ8 (See protein sequence)
Recommended Name: Serine/threonine-protein kinase LMTK1  
Size: 1374 amino acids; 144569 Da
Subunit: Interacts with CDK5
Subcellular location: Membrane; Single-pass type I membrane protein (By similarity). Cytoplasm. Cytoplasm,
perinuclear region. Note=Predominantly perinuclear
Secondary accessions: O75136 Q6ZN31 Q86X28
Alternative splicing: 3 isoforms:  Q6ZMQ8-1   Q6ZMQ8-2   Q6ZMQ8-3   

Explore the universe of human proteins at neXtProt for AATK: NX_Q6ZMQ8

Explore proteomics data for AATK at MOPED 

Post-translational modifications:

  • UniProtKB: Autophosphorylated. Phosphorylated by CDK5
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q6ZMQ8

  • 2 DME Specific Peptides for AATK (Q6ZMQ8)
     CGVLHLH  HSDLALRNC 

    AATK Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    AATK Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001073864.2  NP_004911.2  

    ENSEMBL proteins: 
     ENSP00000324196   ENSP00000460986   ENSP00000363924   ENSP00000398796   ENSP00000460202  

    Human Recombinant Protein Products for AATK: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for AATK
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for AATK
    GenScript Custom Purified and Recombinant Proteins Services for AATK
    Novus Biologicals AATK Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for AATK 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IDA--
    GO:0005783endoplasmic reticulum IEA--
    GO:0016021integral to membrane IEA--
    GO:0044295axonal growth cone IEA--
    GO:0048471perinuclear region of cytoplasm IEA--

    AATK for ontologies           About GeneDecksing



    AATK Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for AATK
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for AATK
    GenScript Custom Superior Antibodies Services for AATK
    Novus Biologicals AATK Antibodies
    Abcam antibodies for AATK
    Cloud-Clone Corp. Antibodies for AATK 
    ThermoFisher Antibodies for AATK
    LSBio Antibodies in human, mouse, rat for AATK 

    Assay Products for AATK: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for AATK
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for AATK
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for AATK 
    Cloud-Clone Corp. CLIAs for AATK


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: apoptosis-associated tyrosine kinase 
    Lmr family

    5 InterPro protein domains:
     IPR017441 Protein_kinase_ATP_BS
     IPR001245 Ser-Thr/Tyr_kinase_cat_dom
     IPR011009 Kinase-like_dom
     IPR000719 Prot_kinase_cat_dom
     IPR008266 Tyr_kinase_AS

    Graphical View of Domain Structure for InterPro Entry Q6ZMQ8

    ProtoNet protein and cluster: Q6ZMQ8

    1 Blocks protein domain: IPB008266 Tyrosine protein kinase

    UniProtKB/Swiss-Prot: LMTK1_HUMAN, Q6ZMQ8
    Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family
    Similarity: Contains 1 protein kinase domain


    AATK for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LMTK1_HUMAN, Q6ZMQ8
    Function: May be involved in neuronal differentiation
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Induction: Up-regulated during apoptosis

         Genatlas biochemistry entry for AATK:
    apoptosis associated tyrosine-kinase (AATYK),murine homolog

         Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity IEA--
    GO:0004713protein tyrosine kinase activity IEA--
    GO:0005515protein binding IPI14521924
    GO:0005524ATP binding IEA--
         
    AATK for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for AATK:
     Decreased focal adhesion (FA)   Decreased substrate adherent c 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Aatk):
     nervous system 

    AATK for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Aatktm1Shhi for AATK

       inGenious Targeting Laboratory - Custom generated mouse model solutions for AATK 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for AATK

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for AATK 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for AATK 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat AATK
    8/28 QIAGEN miScript miRNA Assays for microRNAs that regulate AATK (see all 28):
    hsa-miR-1226 hsa-miR-520d-5p hsa-miR-15a hsa-miR-25 hsa-miR-767-5p hsa-miR-1271 hsa-miR-503 hsa-miR-371-5p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for AATK
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AATK

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for AATK
    Sirion Biotech Customized adenovirus for overexpression of AATK

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for AATK (see all 5)
    OriGene ORF clones in mouse, rat for AATK
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: AATK (NM_001080395)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for AATK
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat AATK
    Sirion Biotech Customized lentivirus for stable overexpression of AATK 
                         Customized lentivirus expression plasmids for stable overexpression of AATK 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for AATK
    Search LifeMap BioReagents cell lines for AATK
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AATK


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for AATK

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for AATK (Q6ZMQ81, 3 ENSP000003241964) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDK5R1Q150781, 3, ENSP000003184864EBI-2008441,EBI-746189 I2D: score=1 STRING: ENSP00000318486
    STK39Q9UEW83, ENSP000003482784I2D: score=1 STRING: ENSP00000348278
    CDK5ENSP000002975184STRING: ENSP00000297518
    PPP1CAENSP000003260314STRING: ENSP00000326031
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation ----
    GO:0006915apoptotic process IEA--
    GO:0007420brain development IEA--
    GO:0030517negative regulation of axon extension IEA--
    GO:0032482Rab protein signal transduction IEA--

    AATK for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for AATK (LMTK1)

    Search CenterWatch for drugs/clinical trials and news about AATK / LMTK1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for AATK gene (2 alternative transcripts): 
    NM_001080395.2  NM_004920.2  

    Unigene Cluster for AATK:

    Apoptosis-associated tyrosine kinase
    Hs.514575  [show with all ESTs]
    Unigene Representative Sequence: NM_001080395
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000326724(uc010dhz.3 uc010dia.3) ENST00000570932 ENST00000374792
    ENST00000417379(uc021ueu.1) ENST00000573469 ENST00000573441 ENST00000572339
    ENST00000576053 ENST00000575363 ENST00000572798
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat AATK
    8/28 QIAGEN miScript miRNA Assays for microRNAs that regulate AATK (see all 28):
    hsa-miR-1226 hsa-miR-520d-5p hsa-miR-15a hsa-miR-25 hsa-miR-767-5p hsa-miR-1271 hsa-miR-503 hsa-miR-371-5p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for AATK
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AATK
    Clone
    Products:
         
    OriGene clones in human, mouse for AATK (see all 5)
    OriGene ORF clones in mouse, rat for AATK
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: AATK (NM_001080395)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for AATK
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat AATK
    Sirion Biotech Customized lentivirus for stable overexpression of AATK 
                         Customized lentivirus expression plasmids for stable overexpression of AATK 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for AATK
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat AATK
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AATK
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AATK

    Additional mRNA sequence: 

    AB014541.2 AK094931.1 AK131395.1 AK131529.1 AK309099.1 BC047378.1 

    9 DOTS entries:

    DT.120937425  DT.97759993  DT.100038796  DT.102841857  DT.120937373  DT.91823357  DT.92444968  DT.95296286 
    DT.100885087 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for AATK (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b
    SP1:                                                                                                                              
    SP2:                                                                          -                                                   
    SP3:                                                                                                  -                           
    SP4:                                                                                                  -                           
    SP5:                                                                                                                              


    ECgene alternative splicing isoforms for AATK

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    AATK expression in normal human tissues (normalized intensities)      AATK embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCCGCAGTC
    AATK Expression
    About this image


    AATK expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Peripheral Nervous System (Nervous System)    fully expand to see all 3 entries
             Pro-myelinating Schwann Cells Peripheral Nerve Domain
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
     
     Brain (Nervous System)
             Trigeminal Ganglion   

    See AATK Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for AATK

    SOURCE GeneReport for Unigene cluster: Hs.514575

    UniProtKB/Swiss-Prot: LMTK1_HUMAN, Q6ZMQ8
    Tissue specificity: Expressed in brain

        SABiosciences Custom PCR Arrays for AATK
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for AATK
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat AATK
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AATK
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AATK
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AATK

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for AATK gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Aatk1 , 5 apoptosis-associated tyrosine kinase1, 5 77.95(n)1
    75.28(a)1
      11 (83.96 cM)5
    113021  NM_001198785.11  NP_001185714.11 
     1200073135 
    chicken
    (Gallus gallus)
    Aves AATK1 apoptosis-associated tyrosine kinase 68.32(n)
    63.34(a)
      422076  XM_420079.3  XP_420079.3 
    lizard
    (Anolis carolinensis)
    Reptilia AATK6
    Uncharacterized protein
    54(a)
    1 ↔ 1
    2(99486276-99509584)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5557391 serine/threonine-protein kinase LMTK1-like 59.75(n)
    58.8(a)
      555739  XM_678332.5  XP_683424.5 
    fruit fly
    (Drosophila melanogaster)
    Insecta otk6
    CG89646
    --
    9(a)
    4(a)
    many ↔ many
    many ↔ many
    2R(7888983-7907329)
    2R(7910651-7912775)


    ENSEMBL Gene Tree for AATK (if available)
    TreeFam Gene Tree for AATK (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for AATK gene
    LMTK22  LMTK32  
    4 SIMAP similar genes for AATK using alignment to 4 protein entries:     LMTK1_HUMAN (see all proteins):
    BTK kinase deficient isoform 6    DKFZp434L0319    FES    tec

    AATK for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1118 SNPs in AATK are shown (see all 1118)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0326814
    An ovarian mucinous carcinoma sample4--see VAR_0326812 M V mis40--------
    VAR_0326804
    A lung adenocarcinoma sample4--see VAR_0326802 L V mis40--------
    VAR_0326794
    An ovarian mucinous carcinoma sample4--see VAR_0326792 S F mis40--------
    rs728541671,2
    C--79091748(+) GGGAAA/GAGGCT 2 -- ut310--------
    rs1908944771,2
    --79091774(+) GTCTCA/GGGGCC 2 -- ut310--------
    rs72207211,2
    C--79091883(+) GGGGCC/TGCCGT 2 -- ut31 ese33Minor allele frequency- T:0.09WA NA 240
    rs774084801,2
    C--79091904(+) ACTGGC/TCCCTT 2 -- ut310--------
    rs728541691,2
    --79092017(+) CATGGC/TCGATC 2 -- ut310--------
    rs1158984001,2
    C,F--79092019(+) TGGCCG/CATCTA 2 -- ut311Minor allele frequency- C:0.03WA 118
    rs1839215571,2
    --79092024(+) GATCTA/GCCATC 2 -- ut310--------

    HapMap Linkage Disequilibrium report for AATK (79091095 - 79139877 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/39 variations for AATK (see all 39):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2716434CNV Deletion23290073
    esv2716433CNV Deletion23290073
    esv2278259CNV Deletion18987734
    esv2716431CNV Deletion23290073
    esv2716427CNV Deletion23290073
    esv1314431CNV Deletion17803354
    esv2716428CNV Deletion23290073
    esv2148507CNV Deletion18987734
    esv2716430CNV Deletion23290073
    esv2716425CNV Deletion23290073

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing AATK
    DNA2.0 Custom Variant and Variant Library Synthesis for AATK

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605276    OMIM disorders: --

    4 diseases for AATK:    About MalaCards
    moyamoya disease    neuroblastoma    adenoma    neuronitis


    AATK for disorders           About GeneDecksing

    Genetic Association Database (GAD): AATK

    Export disorders for AATK gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for AATK gene, integrated from 9 sources (see all 20):
    (articles sorted by number of sources associating them with AATK)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9734811)1, 2, 3 Ishikawa K.... Ohara O. (1998)
    2. Apoptosis-associated tyrosine kinase is a Cdk5 activator p35 binding protein. (PubMed id 14521924)1, 2, 9 Honma N....Hisanaga S. (2003)
    3. Chromosomal assignment of a human apoptosis-associated tyrosine kinase gene on chromosome 17q25.3 by somatic hybrid analysis and fluorescence in situ hybridization. (PubMed id 10083745)1, 3, 9 Seki N....Saito T. (1999)
    4. A novel kinase, AATYK induces and promotes neuronal differentiation in a human neuroblastoma (SH-SY5Y) cell line. (PubMed id 10837911)1, 2, 9 Raghunath M.... Damodar Reddy C. (2000)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    7. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (2002)
    8. Protein phosphatase 1g isoforms linked interactions in the brain. (PubMed id 23080069)1 Esteves S.L....da Cruz e Silva E.F. (2013)
    9. Protein phosphatase 1a interacting proteins in the hum an brain. (PubMed id 22321011)1 Esteves S.L....da Cruz e Silva E.F. (2012)
    10. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)1 Comuzzie A.G....Butte N.F. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9625 HGNC: 21 Ensembl:ENSG00000181409 euGenes: HUgn9625 ECgene: AATK
    H-InvDB: AATK

    (According to HUGE)
    About This Section
    HUGE: KIAA0641

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for AATK Pharmacogenomics, SNPs, Pathways
    CGP resequencing studieshttp://www.sanger.ac.uk/perl/genetics/CGP/cgp_viewer?action=gene&ln=AATK

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for AATK gene:
    Search GeneIP for patents involving AATK

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for AATK (AATK)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for AATK  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for AATK  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for AATK  
     OriGene qSTAR qPCR primer pairs in human, mouse for AATK   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for AATK   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for AATK   OriGene Custom Protein Services for AATK  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat AATK
     QIAGEN SeqTarget long-range PCR primers for resequencing AATK
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AATK
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AATK
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AATK
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AATK
     GenScript Custom Purified and Recombinant Proteins Services for AATK GenScript cDNA clones with any tag delivered in your preferred vector for AATK
     GenScript Custom Assay Services for AATK GenScript Custom Superior Antibodies Services for AATK
     GenScript Custom overexpressing Cell Line Services for AATK CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in AATK promoter
     Search Chromatin IP Primers for AATK
     RT2 qPCR Primer Assay in human, mouse, rat AATK
     GNC Network for AATK
     SABiosciences Custom PCR Arrays for AATK
     Search Tocris compounds for AATK (LMTK1)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     AATK antibodies
     AATK proteins
     Antibodies for AATK
     See all of Abcam's Antibodies, Kits and Proteins for AATK
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for AATK
     Antibodies for AATK
     ELISAs for AATK
     CLIAs for AATK
     Search LifeMap BioReagents cell lines for AATK
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AATK
     Browse SwitchGear 3'UTR luciferase reporter plasmids for AATK
     Browse SwitchGear Promoter luciferase reporter plasmids for AATK
     ThermoFisher Antibodies for AATK
     Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat AATK
     inGenious Targeting Laboratory - Custom generated mouse model solutions for AATK
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for AATK
    Customized:
     lentivirus for stable overexpression of AATK
     lentivirus expression plasmids for stable overexpression of AATK
     adenovirus for overexpression of AATK
     LSBio Antibodies in human, mouse, rat for AATK
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      AATK gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4