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Aliases & Descriptions for AATK
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| AATYK 1, 2, 3, 5 | | AATYK1 1, 2 | | EC 2.7.11.1 3 | | KIAA0641 1, 2, 3 | | LMR1 1, 2, 3 | | LMTK1 1, 2, 3 | | p35BP 2, 3 |
| | | Descriptions |
|---|
| Brain apoptosis-associated tyrosine kinase 3 | | CDK5-binding protein 2, 3 | | Lemur tyrosine kinase 1 2, 3 | | apoptosis-associated tyrosine kinase 2, 3 | | p35-binding protein 2, 3 | | serine/threonine-protein kinase LMTK1 2 |
|
| | Search outside databases for aliases for AATK genePrevious GC identifers: GC17U990147 GC17M082453 GC17M079653 GC17M079791 |
Summaries for AATK(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for AATK: The protein encoded by this gene contains a tyrosine kinase domain at the N-terminus and a proline-rich domain at the C-terminus. This gene is induced during apoptosis, and expression of this gene may be a necessary pre-requisite for the induction of growth arrest and/or apoptosis of myeloid precursor cells. This gene has been shown to produce neuronal differentiation in a neuroblastoma cell line. [provided by RefSeq] UniProtKB/Swiss-Prot: LMTK1_HUMAN, Q6ZMQ8Function: May be involved in neuronal differentiationGene Wiki entry for AATK |
Genomic Location for AATK
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the AATK gene 
Entrez Gene cytogenetic band: 17q25.3 Ensembl cytogenetic band: 17q25.3 HGNC cytogenetic band: 17q25.3AATK Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17M076707:
(about GC identifiers)
Start:
|
76,705,160 bp from pter |
End:
|
76,754,467 bp from pter |
Size:
|
49,308 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000017.9 NT_024871.11
| Proteins for AATK
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: LMTK1_HUMAN, Q6ZMQ8 (See
protein sequence)Recommended Name: Serine/threonine-protein kinase LMTK1 Size: 1374 amino acids; 144569 Da
Subunit: Interacts with CDK5
Subcellular location: Membrane; Single-pass type I membrane protein (By similarity). Cytoplasm. Cytoplasm, perinuclear region. Note=Predominantly perinuclear
Secondary accessions: O75136 Q6ZN31 Q86X28Alternative splicing: 3 isoforms: Q6ZMQ8-1 Q6ZMQ8-2 Q6ZMQ8-3 Post-translational modifications:
Autophosphorylated. Phosphorylated by CDK51
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_001073864.2
ENSEMBL proteins: ENSP00000324196 ENSP00000363924
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
4 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for AATK: Assays for AATK: | Protein
Domains/ Families for AATK(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q6ZMQ8
ProtoNet protein and cluster: Q6ZMQ8 1 Blocks protein family: IPB008266 Tyrosine protein kinase
UniProtKB/Swiss-Prot: LMTK1_HUMAN, Q6ZMQ8Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase familySimilarity: Contains 1 protein kinase domain | Gene Function for AATK
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|                OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_001080395
Applied Biosystems Silencer® siRNAs for AATK
Sigma-Aldrich siRNA and siRNA Panels for AATK  Sigma-Aldrich shRNA Panels and shRNA for AATK  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001080395                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_001080395                                  untagged cDNA clones in CMV expression vector (see all 2): NM_001080395 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_001080395
UniProtKB/Swiss-Prot: LMTK1_HUMAN, Q6ZMQ8Function: May be involved in neuronal differentiationCatalytic activity: ATP + a protein = ADP + a phosphoproteinInduction: Up-regulated during apoptosisEnzyme Number (IUBMB): EC 2.7.11.1 Genatlas biochemistry entry for AATK:apoptosis associated tyrosine-kinase (AATYK),murine homolog5/6 Gene Ontology (GO) molecular function terms (links to tree view) (see all 6
): About this table | Pathways & Interactions for AATK
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
Gene Network CentralTM Interacting Genes and Proteins Network for AATK 
3 Interacting proteins for AATK (ENSP000003241963 Q6ZMQ81) via UniProtKB, MINT, and/or STRINGAbout this table
1 Gene Ontology (GO) biological process term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006468 | protein amino acid phosphorylation |
IEA | -- | About this table
|
Drugs & Compounds for AATK(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for AATK
|
Transcripts for AATK(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|                OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_001080395
Sigma-Aldrich siRNA and siRNA Panels for AATK  Sigma-Aldrich shRNA Panels and shRNA for AATK  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_001080395 REFSEQ mRNAs for AATK gene: NM_001080395.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_001080395               OriGene GFP tagged cDNA clone in CMV expression vector: NM_001080395                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_001080395                                  untagged cDNA clones in CMV expression vector (see all 2): NM_001080395  Additional cDNA sequence: AB014541.2 AK094931.1 AK131395.1 AK131529.1 AK309099.1 BC047378.1 9 DOTS entries: DT.120937425 DT.97759993 DT.100038796 DT.102841857 DT.120937373 DT.91823357 DT.92444968 DT.95296286 DT.100885087
highest scoring ESTs for AATK:AA322346 AK094931 AL120105 AL120847 AL135028 BC047378 BF306070 BG827921 BG899690 BG911396 Unigene Cluster for AATK: Apoptosis-associated tyrosine kinase Hs.514575 [show with all ESTs]Unigene Representative Sequence: NM_001080395
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for AATK (see all 7
)
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | · | 11c | ^ | 12 | ^ | 13a | · | 13b | · | 13c | ^ | 14a | · | 14b | |
| SP1: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for AATK
2 Ensembl transcripts including schematic representations: ENST00000326724
ENST00000374792
|
Expression for AATK
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| AATK expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for AATK
1 / 2 / 3 3 probe-sets matching AATK gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: CCCCGCAGTC
SOURCE GeneReport for Unigene cluster: Hs.514575
Expression variation in blood from EXPOLDB for AATK UniProtKB/Swiss-Prot: LMTK1_HUMAN, Q6ZMQ8Tissue specificity: Expressed in brain |
Orthologs for AATK
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for AATK gene from 4 species
About this table Species with no ortholog for AATK
ENSEMBL Gene Tree for AATK | Paralogs for AATK(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for AATK gene
- LMTK22 LMTK32
|
SNPs/Variants for AATK(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for AATK (up to first 250kb)
|
Disorders & Mutations for AATK
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 605276
|
Medical News for AATK(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for AATK (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/16 PubMed articles for AATK gene (see all 16
):- Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9734811)2, 3, 4 Ishikawa K....Ohara O. (1998)
- Apoptosis-associated tyrosine kinase is a Cdk5 activator p35 binding protein. (PubMed id 14521924)1, 3, 4 Honma N....Hisanaga S. (2003)
- Chromosomal assignment of a human apoptosis-associated tyrosine kinase gene on chromosome 17q25.3 by somatic hybrid analysis and fluorescence in situ hybridization. (PubMed id 10083745)1, 2, 3 Seki N....Saito T. (1999)
- A novel kinase, AATYK induces and promotes neuronal differentiation in a human neuroblastoma (SH-SY5Y) cell line. (PubMed id 10837911)1, 3, 4 Raghunath M.... Damodar Reddy C. (2000)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)3, 4 Ota T....Sugano S. (2004)
- Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)3, 4 Nakajima D.... Nagase T. (2002)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)3 Barbe L....Andersson-Svahn H. (2008)
- Patterns of somatic mutation in human cancer genomes. (PubMed id 17344846)4 Greenman C.... Stratton M.R. (2007)
- Structural and functional analysis of the apoptosis-associated tyrosine kinase (AATYK) family. (PubMed id 17651901)3 Tomomura M....Kamiguchi H. (2007)
|
Search for AATK
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing AATK
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing AATK
(According to HUGE)
About This Section
| |
Specialized Databases showing AATK(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| CGP resequencing studies | http://www.sanger.ac.uk/perl/genetics/CGP/cgp_viewer?action=gene&ln=AATK |
|
| | | About This Section
| --
| Services for AATK(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for AATK:

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