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Aliases for AATK Gene

Aliases for AATK Gene

  • Apoptosis-Associated Tyrosine Kinase 2 3 4 5
  • Lemur Tyrosine Kinase 1 2 3 4
  • Brain Apoptosis-Associated Tyrosine Kinase 3 4
  • CDK5-Binding Protein 3 4
  • P35-Binding Protein 3 4
  • EC 2.7.11.1 4 63
  • AATYK 3 4
  • LMTK1 3 4
  • P35BP 3 4
  • LMR1 3 4
  • Protein Phosphatase 1, Regulatory Subunit 77 3
  • Protein Phosphatase 1 2
  • Regulatory Subunit 77 2
  • EC 2.7.11 63
  • KIAA0641 4
  • PPP1R77 3
  • AATYK1 3

External Ids for AATK Gene

Previous GeneCards Identifiers for AATK Gene

  • GC17U990147
  • GC17M082453
  • GC17M079653
  • GC17M079791
  • GC17M076707
  • GC17M079091

Summaries for AATK Gene

Entrez Gene Summary for AATK Gene

  • The protein encoded by this gene contains a tyrosine kinase domain at the N-terminus and a proline-rich domain at the C-terminus. This gene is induced during apoptosis, and expression of this gene may be a necessary pre-requisite for the induction of growth arrest and/or apoptosis of myeloid precursor cells. This gene has been shown to produce neuronal differentiation in a neuroblastoma cell line. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2011]

GeneCards Summary for AATK Gene

AATK (Apoptosis-Associated Tyrosine Kinase) is a Protein Coding gene. Diseases associated with AATK include neuroblastoma. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is LMTK2.

UniProtKB/Swiss-Prot for AATK Gene

  • May be involved in neuronal differentiation.

Gene Wiki entry for AATK Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AATK Gene

Genomics for AATK Gene

Regulatory Elements for AATK Gene

Promoters for AATK Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around AATK on UCSC Golden Path with GeneCards custom track

Genomic Location for AATK Gene

Chromosome:
17
Start:
81,117,295 bp from pter
End:
81,166,077 bp from pter
Size:
48,783 bases
Orientation:
Minus strand

Genomic View for AATK Gene

Genes around AATK on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AATK Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AATK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AATK Gene

Proteins for AATK Gene

  • Protein details for AATK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZMQ8-LMTK1_HUMAN
    Recommended name:
    Serine/threonine-protein kinase LMTK1
    Protein Accession:
    Q6ZMQ8
    Secondary Accessions:
    • O75136
    • Q6ZN31
    • Q86X28

    Protein attributes for AATK Gene

    Size:
    1374 amino acids
    Molecular mass:
    144569 Da
    Quaternary structure:
    • Interacts with CDK5.

    Alternative splice isoforms for AATK Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AATK Gene

Proteomics data for AATK Gene at MOPED

Selected DME Specific Peptides for AATK Gene

Post-translational modifications for AATK Gene

Other Protein References for AATK Gene

Antibody Products

Domains & Families for AATK Gene

Suggested Antigen Peptide Sequences for AATK Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6ZMQ8

UniProtKB/Swiss-Prot:

LMTK1_HUMAN :
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. Tyr protein kinase family.
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. Tyr protein kinase family.
genes like me logo Genes that share domains with AATK: view

Function for AATK Gene

Molecular function for AATK Gene

GENATLAS Biochemistry:
apoptosis associated tyrosine-kinase (AATYK),murine homolog
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot Function:
May be involved in neuronal differentiation.
UniProtKB/Swiss-Prot Induction:
Up-regulated during apoptosis.

Enzyme Numbers (IUBMB) for AATK Gene

genes like me logo Genes that share phenotypes with AATK: view

Animal Models for AATK Gene

MGI Knock Outs for AATK:

Animal Model Products

miRNA for AATK Gene

miRTarBase miRNAs that target AATK

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for AATK Gene

Localization for AATK Gene

Subcellular locations from UniProtKB/Swiss-Prot for AATK Gene

Membrane; Single-pass type I membrane protein. Cytoplasm. Cytoplasm, perinuclear region. Note=Predominantly perinuclear.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AATK Gene COMPARTMENTS Subcellular localization image for AATK gene
Compartment Confidence
endosome 3
mitochondrion 3
plasma membrane 3
cytosol 2
endoplasmic reticulum 2
cytoskeleton 1
extracellular 1
lysosome 1
nucleus 1
peroxisome 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for AATK Gene

Pathways & Interactions for AATK Gene

SuperPathways for AATK Gene

No Data Available

SIGNOR curated interactions for AATK Gene

Activates:
Inactivates:

Gene Ontology (GO) - Biological Process for AATK Gene

None

No data available for Pathways by source for AATK Gene

Drugs & Compounds for AATK Gene

No Compound Related Data Available

Transcripts for AATK Gene

mRNA/cDNA for AATK Gene

(12) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(10) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for AATK Gene

Apoptosis-associated tyrosine kinase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for AATK Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b
SP1:
SP2: -
SP3: -
SP4: -
SP5:
SP6:
SP7:

Relevant External Links for AATK Gene

GeneLoc Exon Structure for
AATK
ECgene alternative splicing isoforms for
AATK

Expression for AATK Gene

mRNA expression in normal human tissues for AATK Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for AATK Gene

This gene is overexpressed in Nerve - Tibial (x8.4) and Brain - Spinal cord (cervical c-1) (x5.0).

Protein differential expression in normal tissues from HIPED for AATK Gene

This gene is overexpressed in Ovary (35.1), Adipocyte (23.6), and NK cells (10.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for AATK Gene



SOURCE GeneReport for Unigene cluster for AATK Gene Hs.514575

mRNA Expression by UniProt/SwissProt for AATK Gene

Q6ZMQ8-LMTK1_HUMAN
Tissue specificity: Expressed in brain.
genes like me logo Genes that share expression patterns with AATK: view

Protein tissue co-expression partners for AATK Gene

Primer Products

In Situ Assay Products

Orthologs for AATK Gene

This gene was present in the common ancestor of chordates.

Orthologs for AATK Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AATK 35
  • 95.69 (n)
  • 94.49 (a)
AATK 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia AATK 36
  • 72 (a)
OneToOne
AATK 35
  • 81.47 (n)
  • 78.67 (a)
dog
(Canis familiaris)
Mammalia AATK 35
  • 83.36 (n)
  • 81.55 (a)
AATK 36
  • 71 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Aatk 16
Aatk 35
  • 77.8 (n)
  • 75.13 (a)
Aatk 36
  • 69 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia AATK 36
  • 54 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Aatk 35
  • 78.05 (n)
  • 75.52 (a)
chicken
(Gallus gallus)
Aves AATK 35
  • 68.58 (n)
  • 62.94 (a)
AATK 36
  • 48 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia AATK 36
  • 50 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia aatk 35
  • 56.87 (n)
  • 54.95 (a)
zebrafish
(Danio rerio)
Actinopterygii aatka 36
  • 37 (a)
OneToMany
aatkb 36
  • 36 (a)
OneToMany
aatkb 35
  • 60.55 (n)
  • 59.79 (a)
Species with no ortholog for AATK:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for AATK Gene

ENSEMBL:
Gene Tree for AATK (if available)
TreeFam:
Gene Tree for AATK (if available)

Paralogs for AATK Gene

Paralogs for AATK Gene

(4) SIMAP similar genes for AATK Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with AATK: view

Variants for AATK Gene

Sequence variations from dbSNP and Humsavar for AATK Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs8082016 - 81,119,475(+) CGGGC(A/G)TGGGC reference, missense
VAR_032679 An ovarian mucinous carcinoma sample
VAR_032680 A lung adenocarcinoma sample
VAR_032681 An ovarian mucinous carcinoma sample
rs7503604 - 81,121,829(+) GTGGC(A/C/G/T)GCCCG nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for AATK Gene

Variant ID Type Subtype PubMed ID
esv26223 CNV Gain+Loss 19812545
nsv828128 CNV Loss 20364138
dgv3304n71 CNV Loss 21882294
nsv909000 CNV Loss 21882294
dgv3308n71 CNV Loss 21882294
nsv833564 CNV Loss 17160897
nsv909021 CNV Loss 21882294
nsv470619 CNV Loss 18288195
dgv3310n71 CNV Loss 21882294
dgv3311n71 CNV Loss 21882294
dgv3312n71 CNV Loss 21882294
dgv3313n71 CNV Loss 21882294
nsv909037 CNV Loss 21882294
dgv3314n71 CNV Loss 21882294
nsv523417 CNV Gain 19592680
nsv909047 CNV Gain 21882294
dgv3315n71 CNV Loss 21882294
esv2716425 CNV Deletion 23290073
esv2716426 CNV Deletion 23290073
esv2716427 CNV Deletion 23290073
dgv3316n71 CNV Loss 21882294
nsv909052 CNV Loss 21882294
dgv46n68 CNV Loss 17160897
esv1011110 CNV Insertion 20482838
esv2716428 CNV Deletion 23290073
esv2716430 CNV Deletion 23290073
esv2716431 CNV Deletion 23290073
esv271790 CNV Insertion 20981092
dgv3317n71 CNV Loss 21882294
dgv1003e1 CNV Complex 17122850
nsv428351 CNV Gain 18775914
esv2716432 CNV Deletion 23290073
esv2278259 CNV Deletion 18987734
esv2668695 CNV Deletion 23128226
esv2716433 CNV Deletion 23290073
esv2148507 CNV Deletion 18987734
esv2716434 CNV Deletion 23290073
esv1314431 CNV Deletion 17803354
dgv3318n71 CNV Loss 21882294

Variation tolerance for AATK Gene

Gene Damage Index Score: 9.14; 87.82% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for AATK Gene

HapMap Linkage Disequilibrium report
AATK

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AATK Gene

Disorders for AATK Gene

MalaCards: The human disease database

(1) MalaCards diseases for AATK Gene - From: GeneCards

Disorder Aliases PubMed IDs
neuroblastoma
  • neuroblastoma 1
- elite association - COSMIC cancer census association via MalaCards
Search AATK in MalaCards View complete list of genes associated with diseases

Relevant External Links for AATK

Genetic Association Database (GAD)
AATK
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
AATK
genes like me logo Genes that share disorders with AATK: view

No data available for UniProtKB/Swiss-Prot and Genatlas for AATK Gene

Publications for AATK Gene

  1. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9734811) Ishikawa K. … Ohara O. (DNA Res. 1998) 2 3 4 67
  2. Chromosomal assignment of a human apoptosis-associated tyrosine kinase gene on chromosome 17q25.3 by somatic hybrid analysis and fluorescence in situ hybridization. (PMID: 10083745) Seki N. … Saito T. (J. Hum. Genet. 1999) 2 3 23
  3. Apoptosis-associated tyrosine kinase is a Cdk5 activator p35 binding protein. (PMID: 14521924) Honma N. … Hisanaga S. (Biochem. Biophys. Res. Commun. 2003) 3 23
  4. A novel kinase, AATYK induces and promotes neuronal differentiation in a human neuroblastoma (SH-SY5Y) cell line. (PMID: 10837911) Raghunath M. … Damodar Reddy C. (Brain Res. Mol. Brain Res. 2000) 3 23
  5. Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy. (PMID: 25852190) So J. … Colwill K. (Sci Signal 2015) 3

Products for AATK Gene

Sources for AATK Gene

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