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Aliases & Descriptions for AATF
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| | | Descriptions |
|---|
| Apoptosis-antagonizing transcription factor 3 | | Rb-binding protein Che-1 3 | | apoptosis antagonizing transcription factor 2 |
|
| | Search outside databases for aliases for AATF genePrevious GC identifers: GC17P034690 GC17P037258 GC17P035037 GC17P035501 |
Summaries for AATF(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for AATF: The protein encoded by this gene was identified on the basis of its interaction with MAP3K12/DLK, a protein kinase known to be involved in the induction of cell apoptosis. This gene product contains a leucine zipper, which is a characteristic motif of transcription factors, and was shown to exhibit strong transactivation activity when fused to Gal4 DNA binding domain. Overexpression of this gene interfered with MAP3K12 induced apoptosis. [provided by RefSeq] UniProtKB/Swiss-Prot: AATF_HUMAN, Q9NY61Function: May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for this phenomenon has not been described to dateGene Wiki entry for AATF (Apoptosis_antagonizing_transcription_factor) |
Genomic Location for AATF
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the AATF gene 
Entrez Gene cytogenetic band: 17q11.2-q12 Ensembl cytogenetic band: 17q12 HGNC cytogenetic band: 17q12AATF Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17P032380:
(about GC identifiers)
Start:
|
32,380,288 bp from pter |
End:
|
32,488,284 bp from pter |
Size:
|
107,997 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000017.9 NT_078100.1
| Proteins for AATF
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: AATF_HUMAN, Q9NY61 (See
protein sequence)Recommended Name: Protein AATF Size: 560 amino acids; 63133 Da
Subunit: Binds PAWR, POLR2J, RB1/RB, RBL1/P107, RBL2/P130, and SP1. May also bind MAPT
Subcellular location: Nucleus, nucleolus
Sequence caution: Sequence=AAD52016.1; Type=Frameshift; Positions=355, 365, 487, 498, 503;
Secondary accessions: A6NCJ6 B3KQ26 Q9P0A4 Q9UNX5Post-translational modifications:
Hyperphosphorylated during the G1/S phase transition1
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_036270.1
ENSEMBL proteins: ENSP00000225402
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
5 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for AATF: Assays for AATF: | Protein
Domains/ Families for AATF(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q9NY61
ProtoNet protein and cluster: Q9NY61 1 Blocks protein family: IPB012617 TRAUB
UniProtKB/Swiss-Prot: AATF_HUMAN, Q9NY61Similarity: Belongs to the AATF family | Gene Function for AATF
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_012138
Applied Biosystems Silencer® siRNAs for AATF
Sigma-Aldrich siRNA for AATF  Sigma-Aldrich shRNA Panels and shRNA for AATF  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_012138                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_012138                                  untagged cDNA clones in CMV expression vector (see all 2): NM_012138 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_012138
UniProtKB/Swiss-Prot: AATF_HUMAN, Q9NY61Function: May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for this phenomenon has not been described to date4 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Aatf):
2 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for AATF
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
Gene Network CentralTM Interacting Genes and Proteins Network for AATF 
5/44 Interacting proteins for AATF (ENSP000002254023 Q9NY611, 2) via UniProtKB, MINT, and/or STRING (see all 44
)About this table
1 Gene Ontology (GO) biological process term (links to tree view): About this table
|
Drugs & Compounds for AATF(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for AATF 1 Novoseek chemical compound relationship for AATF gene
| Compound |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| leucine |
39.44 |
3 |
15207272 (1), 14627703 (1) |
About this table
|
Transcripts for AATF(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_012138
Sigma-Aldrich siRNA for AATF  Sigma-Aldrich shRNA Panels and shRNA for AATF  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_012138 REFSEQ mRNAs for AATF gene: NM_012138.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_012138               OriGene GFP tagged cDNA clone in CMV expression vector: NM_012138                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_012138                                  untagged cDNA clones in CMV expression vector (see all 2): NM_012138  Additional cDNA sequence: AF083208.1 AF161395.1 AJ249940.2 AK026173.1 AK057229.1 AK130740.1 BC000591.2 CR616929.1 21 DOTS entries: DT.92455094 DT.97860038 DT.99932217 DT.452954 DT.316399 DT.120894106 DT.100799882 DT.100799876 DT.91826648 DT.92455082 DT.95167005 DT.120893889 DT.87017028 DT.95166734 DT.120893894 DT.120894069 DT.91733647 DT.91994800 DT.95167000 DT.120894026 DT.120894145 24/362 AceView cDNA sequences (see all 362
):BU740585 AI817450 F34702 CB150276 BU169820 BG231720 BM855480 BG391551 CB151083 BE312780 BQ056766 BG191682 W77795 BU742473 AI003563 BM713071 AJ249940 AW964198 BQ225065 BC000591 AA290643 BM825155 AA291023 CB125443
highest scoring ESTs for AATF:U51698 AA099988 AA211386 AA291023 AA317577 AA379087 AA379088 AA579979 AA625561 AA625749 Unigene Cluster for AATF: Apoptosis antagonizing transcription factor Hs.195740 [show with all ESTs]Unigene Representative Sequence: NM_012138
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for AATF
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12a | · | 12b | · | 12c | |
| SP1: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | - |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for AATF
1 Ensembl transcript including schematic representation: ENST00000225402
|
Expression for AATF
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| AATF expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for AATF
1 / 2 / 3 3 probe-sets matching AATF gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: GCACCTATTG
SOURCE GeneReport for Unigene cluster: Hs.195740
Expression variation in blood from EXPOLDB for AATF UniProtKB/Swiss-Prot: AATF_HUMAN, Q9NY61Tissue specificity: Ubiquitously expressed. Expressed at high levels in brain, heart, kidney, placenta and thymus |
Orthologs for AATF
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for AATF gene from 5/21 species (see all 21
)
About this table Species with no ortholog for AATF
ENSEMBL Gene Tree for AATF | Paralogs for AATF(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| -- |
SNPs/Variants for AATF(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for AATF (up to first 250kb)
|
Disorders & Mutations for AATF
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 608463
|
Medical News for AATF(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for AATF (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/28 PubMed articles for AATF gene (see all 28
):- Identification of a novel partner of RNA polymerase II subunit 11, Che-1, which interacts with and affects the growth suppression function of Rb. (PubMed id 10783144)1, 2, 3, 4 Fanciulli M....Passananti C. (2000)
- Identification of novel transcription factor-like gene from human intestinal cells. (PubMed id 11027528)2, 3, 4 Lindfors K.... Kainulainen H. (2000)
- AATF inhibits aberrant production of amyloid beta peptide 1-42 by interacting directly with Par-4. (PubMed id 14627703)1, 3, 4 Guo Q. and Xie J. (2004)
- AATF protects neural cells against oxidative damage induced by amyloid beta-peptide. (PubMed id 15207272)1, 3, 4 Xie J. and Guo Q. (2004)
- Rb binding protein Che-1 interacts with Tau in cerebellar granule neurons. Modulation during neuronal apoptosis. (PubMed id 14697667)1, 3, 4 Barbato C....Passananti C. (2003)
- Phosphoproteome analysis of the human mitotic spindle. (PubMed id 16565220)3, 4 Nousiainen M.... Koerner R. (2006)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)3, 4 Olsen J.V....Mann M. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)3, 4 Ota T....Sugano S. (2004)
- Che-1 arrests human colon carcinoma cell proliferation by displacing HDAC1 from the p21WAF1/CIP1 promoter. (PubMed id 12847090)3, 4 Di Padova M....Fanciulli M. (2003)
|
Search for AATF
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing AATF
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing AATF
(According to HUGE)
About This Section
| -- |
Specialized Databases showing AATF(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for AATF(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for AATF:

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