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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

AATF Gene

protein-coding   GIFtS: 56
GCID: GC17P035306

apoptosis antagonizing transcription factor
 Explore 8 diseases affiliated with
AATF via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for AATF    

Aliases
for AATF gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Apoptosis Antagonizing Transcription Factor1 2     Apoptosis-Antagonizing Transcription Factor2 3
CHE11 2 3 5     Rb-Binding Protein Che-12 3
DED1 2 3     Protein AATF2
CHE-11 2     

External Ids:    HGNC: 192351   Entrez Gene: 265742   Ensembl: ENSG000001082707   OMIM: 6084635   UniProtKB: Q9NY613   

Export aliases for AATF gene to outside databases

Previous GC identifers: GC17P034690 GC17P037258 GC17P035037 GC17P035501 GC17P032380 GC17P031244


Summaries
for AATF gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for AATF:
The protein encoded by this gene was identified on the basis of its interaction with MAP3K12/DLK, a protein kinase
known to be involved in the induction of cell apoptosis. This gene product contains a leucine zipper, which is a
characteristic motif of transcription factors, and was shown to exhibit strong transactivation activity when fused to
Gal4 DNA binding domain. Overexpression of this gene interfered with MAP3K12 induced apoptosis. (provided by RefSeq,
Jul 2008)

UniProtKB/Swiss-Prot: AATF_HUMAN, Q9NY61
Function: May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may
displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression.
Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK
inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide
production in Alzheimer disease (presenile and senile dementia), although the molecular basis for this phenomenon has
not been described to date

Gene Wiki entry for AATF (Apoptosis-antagonizing transcription factor)


Genomic Views
for AATF gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010783.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the AATF gene promoter:
         c-Fos   AP-1   p53   ATF-2   ARP-1   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: AATF promoter sequence
   Search SABiosciences Chromatin IP Primers for AATF

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AATF


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q12   Ensembl cytogenetic band:  17q12   HGNC cytogenetic band: 17q12

AATF Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AATF gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P035306:  view genomic region     (about GC identifiers)

Start:
 35,306,175 bp from pter      End:
 35,414,171 bp from pter
Size:
 107,997 bases      Orientation:
 plus strand

Proteins
for AATF gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: AATF_HUMAN, Q9NY61 (See protein sequence)
Recommended Name: Protein AATF  
Size: 560 amino acids; 63133 Da
Subunit: Binds PAWR, POLR2J, RB1/RB, RBL1/P107, RBL2/P130, and SP1. May also bind MAPT
Subcellular location: Nucleus, nucleolus
Sequence caution: Sequence=AAD52016.1; Type=Frameshift; Positions=355, 365, 487, 498, 503;
Secondary accessions: A6NCJ6 B3KQ26 Q9P0A4 Q9UNX5

Explore the universe of human proteins at neXtProt for AATF: NX_Q9NY61

Post-translational modifications:

  • Hyperphosphorylated during the G1/S phase transition1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9NY61

    • AATF Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_036270.1  
    ENSEMBL proteins: 
     ENSP00000225402   ENSP00000466918   ENSP00000468195   ENSP00000465512  
    Reactome Protein details: Q9NY61
    Human Recombinant Protein Products: 
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    Uscn Proteins for AATF

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730nucleolus IDA--
    GO:0005737cytoplasm IDA15207272
    GO:0005794Golgi apparatus IEA--
    GO:0005813centrosome IDA--


    AATF for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for AATF

    Protein Domains /
    Families
    for AATF gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    AATF for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR012617 AATF_C
     IPR025160 AATF

    Graphical View of Domain Structure for InterPro Entry Q9NY61

    ProtoNet protein and cluster: Q9NY61

    1 Blocks protein family: IPB012617 TRAUB

    UniProtKB/Swiss-Prot: AATF_HUMAN, Q9NY61
    Similarity: Belongs to the AATF family


    Function
    for AATF gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: AATF_HUMAN, Q9NY61
    Function: May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may
    displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression.
    Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK
    inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide
    production in Alzheimer disease (presenile and senile dementia), although the molecular basis for this phenomenon has
    not been described to date

    miRNA
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    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003700sequence-specific DNA binding transcription factor activity IDA10580117
    GO:0005515protein binding IPI17157788
    GO:0019904protein domain specific binding ----
    GO:0043522leucine zipper domain binding IPI14627703
    GO:0048156tau protein binding IEA--


    AATF for ontologies           About GeneDecksing


    4 GenomeRNAi human phenotypes for AATF:
     Decreased Salmonella enterica   Decreased Salmonella enterica   Decreased Salmonella enterica   Nucleolar pre-40S maturation d 

    Animal Models:
         4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Aatf):
     cellular  embryogenesis  growth/size  mortality/aging 

    AATF for phenotypes           About GeneDecksing


    Pathways & Interactions
    for AATF gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Cell death signalling via NRAGE, NRIF and NADE
    		Cell death signalling via NRAGE, NRIF and NADE1.00
    		p75 NTR receptor-mediated signalling0.73
    		NRAGE signals death through JNK0.74
    2Regulation of retinoblastoma protein
    		Regulation of retinoblastoma protein1.00
    3Signaling by GPCR
    		Signal Transduction0.56
    4Signaling by FGFR
    		Signalling by NGF0.52

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 BioSystems Pathway for AATF 
        Regulation of retinoblastoma protein

    5        Reactome Pathways for AATF
        Cell death signalling via NRAGE, NRIF and NADE
    Signal Transduction
    Signalling by NGF
    NRAGE signals death through JNK
    p75 NTR receptor-mediated signalling



    AATF for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for AATF

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/51 Interacting proteins for AATF (Q9NY611, 2, 3 ENSP000002254024) via UniProtKB, MINT, STRING, and/or I2D (see all 51)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAPTP106362, 3, ENSP000003408204MINT-49642 MINT-49641 I2D: score=4 STRING: ENSP00000340820
    POLR2JP524352, 3, ENSP000002926144MINT-49955 MINT-49956 I2D: score=4 STRING: ENSP00000292614
    CHEK2O960171, 3, ENSP000003720234EBI-372428,EBI-1180783 I2D: score=4 STRING: ENSP00000372023
    RBBP8Q997082, 3, ENSP000003230504MINT-49961 MINT-49958 MINT-49957 I2D: score=1 STRING: ENSP00000323050
    SP1P080472, 3, ENSP000003293574MINT-49665 MINT-49666 I2D: score=4 STRING: ENSP00000329357
    About this table

    Gene Ontology (GO): 5/14 biological process terms (GO ID links to tree view) (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent ----
    GO:0006915apoptotic process TAS--
    GO:0006974response to DNA damage stimulus IEP18049476
    GO:0007155cell adhesion IEA--
    GO:0007346regulation of mitotic cell cycle IEA--


    AATF for ontologies           About GeneDecksing



    Drugs & Compounds
    for AATF gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    AATF for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for AATF
    2 Novoseek chemical compound relationships for AATF gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leucine 35.6 3 15207272 (1), 14627703 (1)
    doxorubicin 34.9 1 17634135 (1)

    Search CenterWatch for drugs/clinical trials and news about AATF 

    Transcripts
    for AATF gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for AATF gene: 
    NM_012138.3  

    Unigene Cluster for AATF:

    Apoptosis antagonizing transcription factor
    Hs.195740  [show with all ESTs]
    Unigene Representative Sequence: NM_012138
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000225402(uc002hni.3) ENST00000592751 ENST00000589579 ENST00000593084
    ENST00000588486 ENST00000592219 ENST00000587618 ENST00000590321 ENST00000586981


    miRNA
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    Inhib. RNA
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AF083208.1 AF161395.1 AJ249940.2 AK026173.1 AK057229.1 AK130740.1 BC000591.2 

    21 DOTS entries:

    DT.92455094  DT.97860038  DT.452954  DT.99932217  DT.316399  DT.120894106  DT.100799882  DT.100799876 
    DT.91826648  DT.92455082  DT.95167005  DT.120893889  DT.87017028  DT.95166734  DT.120893894  DT.120894069 
    DT.91733647  DT.91994800  DT.95167000  DT.120894026  DT.120894145 

    24/362 AceView cDNA sequences (see all 362):

    CB150276 BM855480 AK130740 AA689384 AL572711 BM714317 CB851947 CR616929 
    CA421296 BG231720 BU169820 AI817450 BM663045 BM727946 BG191682 BE275028 
    BU742473 NM_012138 AW250827 H49202 BG391551 AW964198 W77795 CB108692 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for AATF    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c
    SP1:                                                                                      -                           
    SP2:                    -     -     -                                                                                 
    SP3:                                                                                                                  
    SP4:                                                                                      -     -                     
    SP5:                                                                                                                  


    ECgene alternative splicing isoforms for AATF

    Expression
    for AATF gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    AATF expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GCACCTATTG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See AATF Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for AATF

    SOURCE GeneReport for Unigene cluster: Hs.195740

    UniProtKB/Swiss-Prot: AATF_HUMAN, Q9NY61
    Tissue specificity: Ubiquitously expressed. Expressed at high levels in brain, heart, kidney, placenta and thymus

        SABiosciences Expression via Pathway-Focused PCR Array including AATF: 
              Apoptosis 384HT in human mouse rat

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    In Situ
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    Orthologs
    for AATF gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for AATF gene from 10/32 species (see all 32)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Aatf1 , 5 apoptosis antagonizing transcription factor1, 5 83.75(n)1
    84.13(a)1    		   11 (51.30 cM)5
    563211  NM_019816.11  NP_062790.11 
     844228555 
    chicken
    (Gallus gallus)    		 Aves AATF1 apoptosis antagonizing transcription factor 68.76(n)
    65.43(a)    		   417653  NM_001030724.1  NP_001025895.1 
    lizard
    (Anolis carolinensis)    		 Reptilia AATF6
    		 --
    		 65(a)
    		 1 ↔ 1
    		 GL343439.1(283564-336956)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.70932 Xenopus laevis transcribed sequence with weak similarity more 79.05(n)    CA789933.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii sbcb1092 sbcb109 75.82(n)   321100  BI850048.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG111881 CG11188 46.62(n)
    36.71(a)    		   33943  NM_135222.2  NP_609066.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea Y73E7A.21 Protein Y73E7A.2 41.71(n)
    33.43(a)    		   171723  NM_058469.5  NP_490870.2 
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes BFR21 Bfr2p 41.65(n)
    29.14(a)    		   851893   NP_010585.3 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT5G613301 rRNA processing protein-like protein 45.54(n)
    35.18(a)    		   836254  NM_125526.4  NP_200941.2 
    rice
    (Oryza sativa)    		 Liliopsida Os01g05262001 hypothetical protein 46.06(n)
    36.54(a)    		   4323936  NM_001049762.1  NP_001043227.1 


    ENSEMBL Gene Tree for AATF (if available)
    TreeFam Gene Tree for AATF (if available) 

    Paralogs
    for AATF gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for AATF gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1783 NCBI SNPs in AATF are shown (see all 1783)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 17 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs746966331,2
    		C--35304205(+) CAAGAC/TACTGG 1 -- us2k10--------
    rs1481840581,2
    		--35304247(+) TATTTA/GAGAAT 1 -- us2k10--------
    rs777116661,2
    		C,F,--35304252(+) GAGAAT/CTTGCT 1 -- us2k11Minor allele frequency- C:0.03WA 118
    rs1401256471,2
    		--35304259(+) TGCTCC/TCCTGT 1 -- us2k10--------
    rs745156431,2
    		C,F,--35304284(+) ACTCTC/TAGTTG 1 -- us2k11Minor allele frequency- T:0.09WA 118
    rs1455336631,2
    		--35304298(+) CTTAAC/TTCCTA 1 -- us2k10--------
    rs1171438181,2
    		--35304447(+) AGTAGG/AGACCA 1 -- us2k11Minor allele frequency- A:0.01NA 120
    rs1174726731,2
    		--35304448(+) GTAGGG/TACCAG 1 -- us2k11Minor allele frequency- T:0.01NA 120
    rs1894864831,2
    		--35304461(+) CAGAGA/GAGGGA 1 -- us2k10--------
    rs1925158431,2
    		--35304496(+) TTTTCC/TGCTGA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for AATF (35306175 - 35414171 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 5 variations for AATF
         2 CNVs: 5001 102449
         2 Indels: 45536 25823
         1 Inversion: 37189

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    Disorders / Diseases
    for AATF gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    AATF for disorders           About GeneDecksing

    OMIM gene information: 608463    OMIM disorders: --

    8 diseases for AATF:    About MalaCards
    molluscum contagiosum    colon carcinoma    alzheimer's disease    dementia
    breast cancer    obesity    carcinoma    neuronitis

    Human Genome Epidemiology (HuGE) Navigator: AATF (3 documents)

    Export disorders for AATF gene to outside databases

    Publications
    for AATF gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for AATF gene, integrated from 9 sources (see all 53):
    (articles sorted by number of sources associating them with AATF)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a novel partner of RNA polymerase II subunit 11, Che-1, which interacts with and affects the growth suppression function of Rb. (PubMed id 10783144)1, 2, 3, 9 Fanciulli M.... Passananti C. (2000)
    2. Identification of novel transcription factor-like gene from human intestinal cells. (PubMed id 11027528)1, 2, 3 Lindfors K.... Kainulainen H. (2000)
    3. AATF inhibits aberrant production of amyloid beta peptide 1-42 by interacting directly with Par-4. (PubMed id 14627703)1, 2, 9 Guo Q. and Xie J. (2004)
    4. AATF protects neural cells against oxidative damage induced by amyloid beta-peptide. (PubMed id 15207272)1, 2, 9 Xie J. and Guo Q. (2004)
    5. Rb binding protein Che-1 interacts with Tau in cerebellar granule neurons. Modulation during neuronal apoptosis. (PubMed id 14697667)1, 2, 9 Barbato C....Passananti C. (2003)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Che-1 arrests human colon carcinoma cell proliferation by displacing HDAC1 from the p21WAF1/CIP1 promoter. (PubMed id 12847090)1, 2 Di Padova M....Fanciulli M. (2003)
    9. Che-1 affects cell growth by interfering with the recruitment of HDAC1 by Rb. (PubMed id 12450794)1, 2 Bruno T.... Fanciulli M. (2002)
    10. Functional proteomic analysis of human nucleolus. (PubMed id 12429849)1, 2 Scherl A.... Diaz J.-J. (2002)

    External Searches for AATF gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Genome Databases showing AATF gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 26574 HGNC: 19235 AceView: AATF Ensembl:ENSG00000108270 euGenes: HUgn26574
    ECgene: AATF H-InvDB: AATF

    Other Databases showing AATF gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing AATF gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for AATF Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for AATF Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for AATF gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for AATF gene:
    Search GeneIP for patents involving AATF

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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