Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



AATF Gene

protein-coding   GIFtS: 60
GCID: GC17P035306

Apoptosis Antagonizing Transcription Factor

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Apoptosis Antagonizing Transcription Factor1 2     DED2 3
CHE12 3 5     BFR22
Apoptosis-Antagonizing Transcription Factor2 3     CHE-12
Rb-Binding Protein Che-12 3     Protein AATF2

External Ids:    HGNC: 192351   Entrez Gene: 265742   Ensembl: ENSG000001082707   OMIM: 6084635   UniProtKB: Q9NY613   

Export aliases for AATF gene to outside databases

Previous GC identifers: GC17P034690 GC17P037258 GC17P035037 GC17P035501 GC17P032380 GC17P031244


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for AATF Gene:
The protein encoded by this gene was identified on the basis of its interaction with MAP3K12/DLK, a protein kinase
known to be involved in the induction of cell apoptosis. This gene product contains a leucine zipper, which is a
characteristic motif of transcription factors, and was shown to exhibit strong transactivation activity when
fused to Gal4 DNA binding domain. Overexpression of this gene interfered with MAP3K12 induced apoptosis.
(provided by RefSeq, Jul 2008)

GeneCards Summary for AATF Gene:
AATF (apoptosis antagonizing transcription factor) is a protein-coding gene. Diseases associated with AATF include molluscum contagiosum, and dementia. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and tau protein binding.

UniProtKB/Swiss-Prot: AATF_HUMAN, Q9NY61
Function: May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of
RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle
progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased
expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of
aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular
basis for this phenomenon has not been described to date

Gene Wiki entry for AATF (Apoptosis-antagonizing transcription factor) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000017.11  NC_018928.2  NT_010783.16  NT_187614.1  
Regulatory elements:
   Regulatory transcription factor binding sites in the AATF gene promoter:
         c-Fos   AP-1   p53   ATF-2   ARP-1   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidAATF promoter sequence
   Search Chromatin IP Primers for AATF

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat AATF


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q12   Ensembl cytogenetic band:  17q12   HGNC cytogenetic band: 17q12

AATF Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AATF gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P035306:  view genomic region     (about GC identifiers)

Start:
35,306,175 bp from pter      End:
35,414,171 bp from pter
Size:
107,997 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: AATF_HUMAN, Q9NY61 (See protein sequence)
Recommended Name: Protein AATF  
Size: 560 amino acids; 63133 Da
Subunit: Binds PAWR, POLR2J, RB1/RB, RBL1/P107, RBL2/P130, and SP1. May also bind MAPT
Sequence caution: Sequence=AAD52016.1; Type=Frameshift; Positions=355, 365, 487, 498, 503;
Secondary accessions: A6NCJ6 B3KQ26 Q9P0A4 Q9UNX5

Explore the universe of human proteins at neXtProt for AATF: NX_Q9NY61

Explore proteomics data for AATF at MOPED

Post-translational modifications: 

  • Hyperphosphorylated during the G1/S phase transition1
  • Ubiquitination2 at Lys159, Lys228, Lys246, Lys403, Lys475, Lys496, Lys522
  • Modification sites at PhosphoSitePlus

  • See AATF Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_036270.1  
    ENSEMBL proteins: 
     ENSP00000225402   ENSP00000466918   ENSP00000468195   ENSP00000465512  
    Reactome Protein details: Q9NY61

    AATF Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for AATF
    OriGene Custom MassSpec
    OriGene Custom Protein Services for AATF
    GenScript Custom Purified and Recombinant Proteins Services for AATF
    Novus Biologicals AATF Proteins
    Novus Biologicals AATF Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for AATF

    AATF Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for AATF
    OriGene Custom Antibody Services for AATF
    Novus Biologicals AATF Antibodies
    Abcam antibodies for AATF
    Cloud-Clone Corp. Antibodies for AATF
    ThermoFisher Antibodies for AATF
    LSBio Antibodies in human, mouse, rat for AATF

    AATF Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for AATF
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for AATF
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for AATF
    Cloud-Clone Corp. CLIAs for AATF


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    2 InterPro protein domains:
     IPR012617 AATF_C
     IPR025160 AATF

    Graphical View of Domain Structure for InterPro Entry Q9NY61

    ProtoNet protein and cluster: Q9NY61

    1 Blocks protein domain: IPB012617 TRAUB

    UniProtKB/Swiss-Prot: AATF_HUMAN, Q9NY61
    Similarity: Belongs to the AATF family


    AATF for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AATF_HUMAN, Q9NY61
    Function: May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of
    RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle
    progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased
    expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of
    aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular
    basis for this phenomenon has not been described to date

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003700sequence-specific DNA binding transcription factor activity IDA10580117
    GO:0005515protein binding IPI10783144
    GO:0019904protein domain specific binding ----
    GO:0043522leucine zipper domain binding IPI10580117
    GO:0044822poly(A) RNA binding IDA--
         
    AATF for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for AATF:
     Decreased Salmonella enterica   Decreased Salmonella enterica   Decreased Salmonella enterica   Nucleolar pre-40S maturation d 

         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Aatf):
     cellular  embryogenesis  growth/size/body  mortality/aging 

    AATF for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for AATF
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for AATF

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for AATF
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for AATF

    miRNA
    Products:
        
    miRTarBase miRNAs that target AATF:
    hsa-let-7b-5p (MIRT052353), hsa-mir-151a-3p (MIRT043604), hsa-mir-124-3p (MIRT022994), hsa-mir-149-5p (MIRT045596)

    Block miRNA regulation of human, mouse, rat AATF using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate AATF
    SwitchGear 3'UTR luciferase reporter plasmidAATF 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for AATF
    Predesigned siRNA for gene silencing in human, mouse, rat AATF

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for AATF

    Clone
    Products:
         
    OriGene clones in human, mouse for AATF (see all 7)
    OriGene ORF clones in mouse, rat for AATF
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: AATF (NM_012138)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for AATF
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AATF

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for AATF
    Browse ESI BIO Cell Lines and PureStem Progenitors for AATF 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AATF


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    AATF_HUMAN, Q9NY61: Nucleus, nucleolus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytoskeleton4
    cytosol2
    golgi apparatus2
    extracellular1
    plasma membrane1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730nucleolus IDA--
    GO:0005737cytoplasm IDA14627703
    GO:0005794Golgi apparatus IEA--
    GO:0005813centrosome IDA--

    AATF for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for AATF About    
    See pathways by source

    SuperPathContained pathways About
    1p75 NTR receptor-mediated signalling
    p75 NTR receptor-mediated signalling0.74
    NRAGE signals death through JNK0.71
    Cell death signalling via NRAGE, NRIF and NADE0.74
    2Signaling by FGFR
    Signalling by NGF0.71
    3Signaling by GPCR
    Signal Transduction0.58
    4Regulation of retinoblastoma protein
    Regulation of retinoblastoma protein

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for AATF
        Regulation of retinoblastoma protein

    1 Reactome Pathway for AATF
        NRAGE signals death through JNK



    AATF for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including AATF: 
              Apoptosis 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for AATF

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for AATF (Q9NY611, 2, 3 ENSP000002254024) via UniProtKB, MINT, STRING, and/or I2D (see all 197)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAPTP106362, 3, ENSP000003408204MINT-49642 MINT-49641 I2D: score=4 STRING: ENSP00000340820
    POLR2JP524352, 3, ENSP000002926144MINT-49955 MINT-49956 I2D: score=4 STRING: ENSP00000292614
    SP1P080472, 3, ENSP000003293574MINT-49665 MINT-49666 I2D: score=4 STRING: ENSP00000329357
    LDOC1O957512, 3, ENSP000003595574MINT-67077 I2D: score=5 STRING: ENSP00000359557
    CHEK2O960171, 3, ENSP000003720234EBI-372428,EBI-1180783 I2D: score=4 STRING: ENSP00000372023
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006974cellular response to DNA damage stimulus IEP18049476
    GO:0007155cell adhesion IEA--
    GO:0007346regulation of mitotic cell cycle IEA--
    GO:0032929negative regulation of superoxide anion generation IDA15207272
    GO:0040016embryonic cleavage IEA--

    AATF for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for AATF

    2 Novoseek inferred chemical compound relationships for AATF gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leucine 35.6 3 15207272 (1), 14627703 (1)
    doxorubicin 34.9 1 17634135 (1)



    AATF for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for AATF gene: 
    NM_012138.3  

    Unigene Cluster for AATF:

    Apoptosis antagonizing transcription factor
    Hs.195740  [show with all ESTs]
    Unigene Representative Sequence: NM_012138
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000225402(uc002hni.3) ENST00000592751 ENST00000589579 ENST00000593084
    ENST00000588486 ENST00000592219 ENST00000587618 ENST00000590321 ENST00000586981

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat AATF using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate AATF
    SwitchGear 3'UTR luciferase reporter plasmidAATF 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for AATF
    Predesigned siRNA for gene silencing in human, mouse, rat AATF
    Clone
    Products:
         
    OriGene clones in human, mouse for AATF (see all 7)
    OriGene ORF clones in mouse, rat for AATF
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: AATF (NM_012138)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for AATF
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AATF
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for AATF
    OriGene qSTAR qPCR primer pairs in human, mouse for AATF
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat AATF
      QuantiTect SYBR Green Assays in human, mouse, rat AATF
      QuantiFast Probe-based Assays in human, mouse, rat AATF

    Additional mRNA sequence: 

    AF083208.1 AF161395.1 AJ249940.2 AK026173.1 AK057229.1 AK130740.1 BC000591.2 

    21 DOTS entries:

    DT.92455094  DT.97860038  DT.99932217  DT.452954  DT.316399  DT.120894106  DT.100799882  DT.91826648 
    DT.100799876  DT.92455082  DT.95167005  DT.120893889  DT.87017028  DT.95166734  DT.120893894  DT.120894069 
    DT.91733647  DT.91994800  DT.95167000  DT.120894026  DT.120894145 

    Selected AceView cDNA sequences (see all 362):

    CB851947 BM714317 BU169820 AI817450 BM663045 BM727946 BG191682 BU742473 
    BE275028 NM_012138 AW250827 H49202 BG391551 AW964198 W77795 CB108692 
    BU193913 AA379088 BU740665 BM713071 AJ249940 AF161395 BM825155 AA291023 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for AATF    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c
    SP1:                                                                                      -                           
    SP2:                    -     -     -                                                                                 
    SP3:                                                                                                                  
    SP4:                                                                                      -     -                     
    SP5:                                                                                                                  


    ECgene alternative splicing isoforms for AATF

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    AATF expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCACCTATTG
    AATF Expression
    About this image


    AATF expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Thymus (Hematopoietic System)
             Thymus
     
     Kidney (Urinary System)
             Metanephros
     
     Neural Tube (Nervous System)
             Diencephalon
     
     Brain (Nervous System)
             Cerebellum
    AATF Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    AATF Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.195740

    UniProtKB/Swiss-Prot: AATF_HUMAN, Q9NY61
    Tissue specificity: Ubiquitously expressed. Expressed at high levels in brain, heart, kidney, placenta and thymus

        Pathway & Disease-focused RT2 Profiler PCR Array including AATF: 
              Apoptosis 384HT in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for AATF
    OriGene qSTAR qPCR primer pairs in human, mouse for AATF
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat AATF
    QuantiTect SYBR Green Assays in human, mouse, rat AATF
    QuantiFast Probe-based Assays in human, mouse, rat AATF
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AATF

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for AATF gene from Selected species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Aatf1 , 5 apoptosis antagonizing transcription factor1, 5 83.17(n)1
    82.86(a)1
      11 (51.30 cM)5
    563211  NM_019816.11  NP_062790.11 
     844228555 
    chicken
    (Gallus gallus)
    Aves AATF1 apoptosis antagonizing transcription factor 68.89(n)
    66.23(a)
      417653  NM_001030724.1  NP_001025895.1 
    lizard
    (Anolis carolinensis)
    Reptilia AATF6
    apoptosis antagonizing transcription factor
    61(a)
    1 ↔ 1
    GL343439.1(261718-337118)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.70932 Xenopus laevis transcribed sequence with weak similarity more 79.05(n)    CA789933.1 
    zebrafish
    (Danio rerio)
    Actinopterygii sbcb1092 sbcb109 75.82(n)   321100  BI850048.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG111886
    --
    34(a)
    1 ↔ 1
    2L(6717625-6719389)
    worm
    (Caenorhabditis elegans)
    Secernentea Y73E7A.21 Y73E7A.2 42.16(n)
    33.99(a)
      171723  NM_058469.6  NP_490870.2 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes BFR26
    Essential protein that is a component of 90S preri...
    23(a)
    1 ↔ 1
    IV(1059627-1061231) YDR299W
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G613301 AT5G61330 46.06(n)
    37.19(a)
      836254  NM_125526.4  NP_200941.2 
    rice
    (Oryza sativa)
    Liliopsida Os01g05262001 Os01g0526200 45.77(n)
    37.69(a)
      4323936  NM_001049762.1  NP_001043227.1 


    ENSEMBL Gene Tree for AATF (if available)
    TreeFam Gene Tree for AATF (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for AATF (see all 2098)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs610308391,2
    C--31275468(+) TTTTT-/T/TT  
            
    GAGTA
    1 -- int11NA 2
    rs746966331,2
    C--35304205(+) CAAGAC/TACTGG 1 -- us2k10--------
    rs1481840581,2
    --35304247(+) TATTTA/GAGAAT 1 -- us2k10--------
    rs777116661,2
    C,F--35304252(+) GAGAAT/CTTGCT 1 -- us2k11Minor allele frequency- C:0.03WA 118
    rs1401256471,2
    --35304259(+) TGCTCC/TCCTGT 1 -- us2k10--------
    rs745156431,2
    C,F--35304284(+) ACTCTC/TAGTTG 1 -- us2k11Minor allele frequency- T:0.09WA 118
    rs1455336631,2
    --35304298(+) CTTAAC/TTCCTA 1 -- us2k10--------
    rs1171438181,2
    C,F--35304447(+) AGTAGG/AGACCA 1 -- us2k11Minor allele frequency- A:0.01NA 120
    rs1174726731,2
    F--35304448(+) GTAGGG/TACCAG 1 -- us2k11Minor allele frequency- T:0.01NA 120
    rs1894864831,2
    C--35304461(+) CAGAGA/GAGGGA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for AATF (35306175 - 35414171 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for AATF:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1366836CNV Deletion17803354
    esv2315584CNV Deletion18987734
    esv2715886CNV Deletion23290073
    esv2457233CNV Deletion19546169
    nsv112350CNV Insertion16902084
    nsv112468CNV Insertion16902084
    nsv833430CNV Gain+Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing AATF
    DNA2.0 Custom Variant and Variant Library Synthesis for AATF

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 608463    OMIM disorders: --

    12 diseases for AATF:    
    About MalaCards
    molluscum contagiosum    dementia    retinoblastoma    obesity
    alzheimer's disease    hiv-1    multiple myeloma    myeloma
    cerebritis    malaria    breast cancer    neuronitis


    AATF for disorders           About GeneDecksing

    Genetic Association Database (GAD): AATF
    Human Genome Epidemiology (HuGE) Navigator: AATF (3 documents)

    Export disorders for AATF gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for AATF gene, integrated from 10 sources (see all 63):
    (articles sorted by number of sources associating them with AATF)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a novel partner of RNA polymerase II subunit 11, Che-1, which interacts with and affects the growth suppression function of Rb. (PubMed id 10783144)1, 2, 3, 9 Fanciulli M.... Passananti C. (FASEB J. 2000)
    2. Identification of novel transcription factor-like gene from human intestinal cells. (PubMed id 11027528)1, 2, 3 Lindfors K.... Kainulainen H. (Biochem. Biophys. Res. Commun. 2000)
    3. AATF inhibits aberrant production of amyloid beta peptide 1-42 by interacting directly with Par-4. (PubMed id 14627703)1, 2, 9 Guo Q. and Xie J. (J. Biol. Chem. 2004)
    4. AATF protects neural cells against oxidative damage induced by amyloid beta-peptide. (PubMed id 15207272)1, 2, 9 Xie J. and Guo Q. (Neurobiol. Dis. 2004)
    5. Rb binding protein Che-1 interacts with Tau in cerebellar granule neurons. Modulation during neuronal apoptosis. (PubMed id 14697667)1, 2, 9 Barbato C....Passananti C. (Mol. Cell. Neurosci. 2003)
    6. Use of genome-wide expression data to mine the &quot;Gray Zone&quot; of GWA studies leads to novel candidate obesity genes. (PubMed id 20532202)1, 4 Naukkarinen J....Peltonen L. (PLoS Genet. 2010)
    7. Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging. (PubMed id 19834535)1, 4 Wheeler H.E....Kim S.K. (PLoS Genet. 2009)
    8. Mutation analysis of the AATF gene in breast cancer families. (PubMed id 20025740)1, 4 HaanpAoAo M....Winqvist R. (BMC Cancer 2009)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 26574 HGNC: 19235 AceView: AATF Ensembl:ENSG00000108270 euGenes: HUgn26574
    ECgene: AATF H-InvDB: AATF

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for AATF Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for AATF Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for AATF gene:
    Search GeneIP for patents involving AATF

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for AATF   OriGene RNAi products in human, mouse, rat for AATF  
     OriGene qPCR primer pairs and template standards for AATF   OriGene Protein Over-expression Lysate for AATF  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for AATF  
     OriGene qSTAR qPCR primer pairs in human, mouse for AATF   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for AATF   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for AATF   OriGene Custom Protein Services for AATF  

     
     
     Block miRNA regulation of human, mouse, rat AATF using miScript Target Protectors SeqTarget long-range PCR primers for resequencing AATF
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat AATF Predesigned siRNA for gene silencing in human, mouse, rat AATF
     QuantiFast Probe-based Assays in human, mouse, rat AATF QuantiTect SYBR Green Assays in human, mouse, rat AATF
     PCR Arrays including human, mouse, rat AATF Search Chromatin IP Primers for AATF
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat AATF  GeneGlobe Interaction Network for AATF
     Regulatory tfbs in AATF promoter
     GenScript Custom Purified and Recombinant Proteins Services for AATF GenScript cDNA clones with any tag delivered in your preferred vector for AATF
     GenScript Custom Assay Services for AATF GenScript Custom overexpressing Cell Line Services for AATF
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for AATF
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     AATF antibodies
     AATF proteins
     AATF lysates
     Antibodies for AATF
     See all of Abcam's Antibodies, Kits and Proteins for AATF
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for AATF
     Antibodies for AATF
     ELISAs for AATF
     CLIAs for AATF



     Browse ESI BIO Cell Lines and PureStem Progenitors for AATF
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AATF
     SwitchGear 3'UTR luciferase reporter plasmids for AATF
     SwitchGear Promoter luciferase reporter plasmids for AATF
     ThermoFisher Antibodies for AATF
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AATF
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for AATF
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for AATF
     LSBio Antibodies in human, mouse, rat for AATF
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      AATF gene at Home site.
    Version: 3.12.166 28 Aug 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4