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Aliases for AATF Gene

Aliases for AATF Gene

  • Apoptosis Antagonizing Transcription Factor 2 3 5
  • Apoptosis-Antagonizing Transcription Factor 3 4
  • Rb-Binding Protein Che-1 3 4
  • CHE1 3 4
  • DED 3 4
  • CHE-1 3
  • BFR2 3

External Ids for AATF Gene

Previous GeneCards Identifiers for AATF Gene

  • GC17P034690
  • GC17P037258
  • GC17P035037
  • GC17P035501
  • GC17P032380
  • GC17P035306
  • GC17P031244

Summaries for AATF Gene

Entrez Gene Summary for AATF Gene

  • The protein encoded by this gene was identified on the basis of its interaction with MAP3K12/DLK, a protein kinase known to be involved in the induction of cell apoptosis. This gene product contains a leucine zipper, which is a characteristic motif of transcription factors, and was shown to exhibit strong transactivation activity when fused to Gal4 DNA binding domain. Overexpression of this gene interfered with MAP3K12 induced apoptosis. [provided by RefSeq, Jul 2008]

GeneCards Summary for AATF Gene

AATF (Apoptosis Antagonizing Transcription Factor) is a Protein Coding gene. Diseases associated with AATF include chromosome 17q12 deletion syndrome and eastern equine encephalitis. Among its related pathways are Signaling by GPCR and p75 NTR receptor-mediated signalling. GO annotations related to this gene include poly(A) RNA binding and protein domain specific binding.

UniProtKB/Swiss-Prot for AATF Gene

  • May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for this phenomenon has not been described to date.

Gene Wiki entry for AATF Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AATF Gene

Genomics for AATF Gene

Regulatory Elements for AATF Gene

Promoters for AATF Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around AATF on UCSC Golden Path with GeneCards custom track

Genomic Location for AATF Gene

Chromosome:
17
Start:
36,948,875 bp from pter
End:
37,056,871 bp from pter
Size:
107,997 bases
Orientation:
Plus strand

Genomic View for AATF Gene

Genes around AATF on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AATF Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AATF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AATF Gene

Proteins for AATF Gene

  • Protein details for AATF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NY61-AATF_HUMAN
    Recommended name:
    Protein AATF
    Protein Accession:
    Q9NY61
    Secondary Accessions:
    • A6NCJ6
    • B3KQ26
    • Q9P0A4
    • Q9UNX5

    Protein attributes for AATF Gene

    Size:
    560 amino acids
    Molecular mass:
    63133 Da
    Quaternary structure:
    • Binds PAWR, POLR2J, RB1/RB, RBL1/P107, RBL2/P130, and SP1. May also bind MAPT.
    SequenceCaution:
    • Sequence=AAD52016.1; Type=Frameshift; Positions=355, 365, 487, 498, 503; Evidence={ECO:0000305};

neXtProt entry for AATF Gene

Proteomics data for AATF Gene at MOPED

Post-translational modifications for AATF Gene

  • Hyperphosphorylated during the G1/S phase transition.
  • Ubiquitination at Lys 159, Lys 228, Lys 246, Lys 403, Lys 475, Lys 496, and Lys 522
  • Modification sites at PhosphoSitePlus

Other Protein References for AATF Gene

Antibody Products

No data available for DME Specific Peptides for AATF Gene

Domains & Families for AATF Gene

Protein Domains for AATF Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for AATF Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NY61

UniProtKB/Swiss-Prot:

AATF_HUMAN :
  • Belongs to the AATF family.
Family:
  • Belongs to the AATF family.
genes like me logo Genes that share domains with AATF: view

No data available for Gene Families for AATF Gene

Function for AATF Gene

Molecular function for AATF Gene

UniProtKB/Swiss-Prot Function:
May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for this phenomenon has not been described to date.

Gene Ontology (GO) - Molecular Function for AATF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA --
GO:0005515 protein binding IEA,IPI 10783144
genes like me logo Genes that share ontologies with AATF: view
genes like me logo Genes that share phenotypes with AATF: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for AATF Gene

Localization for AATF Gene

Subcellular locations from UniProtKB/Swiss-Prot for AATF Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AATF Gene COMPARTMENTS Subcellular localization image for AATF gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 3
golgi apparatus 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for AATF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 10580117
genes like me logo Genes that share ontologies with AATF: view

Pathways & Interactions for AATF Gene

genes like me logo Genes that share pathways with AATF: view

SIGNOR curated interactions for AATF Gene

Is activated by:

Gene Ontology (GO) - Biological Process for AATF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
GO:0007346 regulation of mitotic cell cycle IEA --
GO:0042254 ribosome biogenesis IEA --
GO:0043066 negative regulation of apoptotic process IMP 15207272
GO:0045893 positive regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with AATF: view

Drugs & Compounds for AATF Gene

(2) Drugs for AATF Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with AATF: view

Transcripts for AATF Gene

Unigene Clusters for AATF Gene

Apoptosis antagonizing transcription factor:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for AATF Gene

No ASD Table

Relevant External Links for AATF Gene

GeneLoc Exon Structure for
AATF
ECgene alternative splicing isoforms for
AATF

Expression for AATF Gene

mRNA expression in normal human tissues for AATF Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for AATF Gene

This gene is overexpressed in Lung (17.6), Blymphocyte (11.6), Pancreas (9.2), and CD8 Tcells (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for AATF Gene



SOURCE GeneReport for Unigene cluster for AATF Gene Hs.195740

mRNA Expression by UniProt/SwissProt for AATF Gene

Q9NY61-AATF_HUMAN
Tissue specificity: Ubiquitously expressed. Expressed at high levels in brain, heart, kidney, placenta and thymus.
genes like me logo Genes that share expression patterns with AATF: view

Protein tissue co-expression partners for AATF Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for AATF Gene

Orthologs for AATF Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for AATF Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AATF 35
  • 99.52 (n)
  • 99.64 (a)
cow
(Bos Taurus)
Mammalia AATF 35
  • 85.66 (n)
  • 85.84 (a)
dog
(Canis familiaris)
Mammalia AATF 35
  • 87.85 (n)
  • 87.97 (a)
mouse
(Mus musculus)
Mammalia Aatf 35
  • 83.17 (n)
  • 82.86 (a)
Aatf 16
rat
(Rattus norvegicus)
Mammalia Aatf 35
  • 83.52 (n)
  • 83.91 (a)
chicken
(Gallus gallus)
Aves AATF 35
  • 68.89 (n)
  • 66.23 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.7093 35
tropical clawed frog
(Silurana tropicalis)
Amphibia aatf 35
  • 64.73 (n)
  • 63.93 (a)
Str.10137 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13361 35
zebrafish
(Danio rerio)
Actinopterygii aatf 35
  • 60.93 (n)
  • 58.79 (a)
sbcb109 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007394 35
  • 47.27 (n)
  • 36.85 (a)
worm
(Caenorhabditis elegans)
Secernentea Y73E7A.2 35
  • 42.16 (n)
  • 33.99 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G61330 35
  • 46.06 (n)
  • 37.19 (a)
rice
(Oryza sativa)
Liliopsida Os01g0526200 35
  • 45.77 (n)
  • 37.69 (a)
Species with no ortholog for AATF:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for AATF Gene

ENSEMBL:
Gene Tree for AATF (if available)
TreeFam:
Gene Tree for AATF (if available)

Paralogs for AATF Gene

No data available for Paralogs for AATF Gene

Variants for AATF Gene

Sequence variations from dbSNP and Humsavar for AATF Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs730003 -- 37,017,495(+) GGATT(G/T)GGATC intron-variant
rs1266179 -- 37,021,822(+) AAAAA(A/T)AATAA intron-variant
rs2306657 -- 36,949,090(-) CGCAC(A/G)TAAAT nc-transcript-variant, utr-variant-5-prime
rs2411164 -- 36,956,616(-) GGCTC(A/G)CTGCA intron-variant
rs2411165 -- 36,973,996(-) cacct(C/T)ccagg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for AATF Gene

Variant ID Type Subtype PubMed ID
nsv833430 CNV Gain+Loss 17160897
esv2457233 CNV Deletion 19546169
esv2715886 CNV Deletion 23290073
esv2315584 CNV Deletion 18987734
esv1366836 CNV Deletion 17803354
nsv112350 CNV Insertion 16902084
nsv112468 CNV Insertion 16902084

Variation tolerance for AATF Gene

Residual Variation Intolerance Score: 40.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.80; 58.29% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for AATF Gene

HapMap Linkage Disequilibrium report
AATF
Human Gene Mutation Database (HGMD)
AATF

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AATF Gene

Disorders for AATF Gene

MalaCards: The human disease database

(4) MalaCards diseases for AATF Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
chromosome 17q12 deletion syndrome
  • 17q12 microdeletion syndrome
eastern equine encephalitis
  • eee
lacrimal apparatus disease
  • lacrimal apparatus diseases
alzheimer disease
  • alzheimer disease, late-onset
- elite association - COSMIC cancer census association via MalaCards
Search AATF in MalaCards View complete list of genes associated with diseases

Relevant External Links for AATF

Genetic Association Database (GAD)
AATF
Human Genome Epidemiology (HuGE) Navigator
AATF
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
AATF
genes like me logo Genes that share disorders with AATF: view

No data available for UniProtKB/Swiss-Prot and Genatlas for AATF Gene

Publications for AATF Gene

  1. Identification of a novel partner of RNA polymerase II subunit 11, Che-1, which interacts with and affects the growth suppression function of Rb. (PMID: 10783144) Fanciulli M. … Passananti C. (FASEB J. 2000) 2 3 4 23 67
  2. Functional characterization of AATF transcriptome in human leukemic cells. (PMID: 17006618) Kaul D. … Mehrotra A. (Mol. Cell. Biochem. 2007) 3 23
  3. NRAGE associates with the anti-apoptotic factor Che-1 and regulates its degradation to induce cell death. (PMID: 17488777) Di Certo M.G. … Passananti C. (J. Cell. Sci. 2007) 3 23
  4. TSG101 interacts with apoptosis-antagonizing transcription factor and enhances androgen receptor-mediated transcription by promoting its monoubiquitination. (PMID: 14761944) Burgdorf S. … Scheidtmann K.H. (J. Biol. Chem. 2004) 3 23
  5. AATF inhibits aberrant production of amyloid beta peptide 1-42 by interacting directly with Par-4. (PMID: 14627703) Guo Q. … Xie J. (J. Biol. Chem. 2004) 3 23

Products for AATF Gene

Sources for AATF Gene

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