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AASS Gene

protein-coding GIFtS: 54

GC07M121503

aminoadipate-semialdehyde synthase
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
LKR/SDH ^², ³
LKRSDH ^¹, ²
LORSDH ^¹, ²

Descriptions
alpha-aminoadipate semialdehyde synthase ^²
aminoadipate-semialdehyde synthase ^²
aminoadipic semialdehyde synthase ^²
lysine-2-oxoglutarate reductase ^²
lysine-ketoglutarate reductase /saccharopine dehydrogenase ^²

External Ids
HGNC: 17366¹
Entrez Gene: 10157²
UniProtKB: Q9UDR5³
Ensembl: ENSG00000008311⁷

Search outside databases for aliases for AASS gene

Previous GC identifers: GC07M120194 GC07M121256 GC07M121270 GC07M121310

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for AASS:

This gene encodes a bifunctional enzyme that catalyzes the first two steps in the mammalian lysine

degradation pathway. The N-terminal and the C-terminal portions of this enzyme contain

lysine-ketoglutarate reductase and saccharopine dehydrogenase activity, respectively, resulting in

the conversion of lysine to alpha-aminoadipic semialdehyde. Mutations in this gene are associated

with familial hyperlysinemia. [provided by RefSeq]

UniProtKB/Swiss-Prot: AASS_HUMAN, Q9UDR5

Function: Bifunctional enzyme that catalyzes the first two steps in lysine degradation. The

N-terminal and the C-terminal contain lysine-ketoglutarate reductase and saccharopine

dehydrogenase activity, respectively

Gene Wiki entry for AASS

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the AASS gene

Entrez Gene cytogenetic band: 7q31.3 Ensembl cytogenetic band: 7q31.32 HGNC cytogenetic band: 7q31.3

AASS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 7 GeneLoc Exon Structure

GeneLoc location for GC07M121503: (about GC identifiers)

Start:	121,503,423 bp from pter
End:	121,571,504 bp from pter
Size:	68,082 bases
Orientation:	minus strand

1 alternative location:

Chr7-,CRA_TCAG 121,110,861-121,168,545

RefSeq DNA sequence:

NC_000007.12 NT_007933.14 NT_079596.2

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: AASS_HUMAN, Q9UDR5 (See protein sequence)

Recommended Name: Alpha-aminoadipic semialdehyde synthase, mitochondrial precursor

Size: 926 amino acids; 102132 Da

Subunit: Homodimer (By similarity)

Subcellular location: Mitochondrion (By similarity)

Secondary accessions: O95462

REFSEQ proteins: NP_005754.2

ENSEMBL proteins:

ENSP00000351834 ENSP00000377040

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
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	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005739	mitochondrion	TAS	10567240

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Antibodies for AASS:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for AASS
	Browse R&D Systems for Antibodies
	Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for AASS

Assays for AASS:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q9UDR5

ProtoNet protein and cluster: Q9UDR5

UniProtKB/Swiss-Prot: AASS_HUMAN, Q9UDR5

Similarity: In the N-terminal section; belongs to the AlaDH/PNT family

Similarity: In the C-terminal section; belongs to the saccharopine dehydrogenase family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (AASS)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005763

Applied Biosystems Silencer® siRNAs for AASS

Sigma-Aldrich siRNA and siRNA Panels for AASS

Sigma-Aldrich shRNA for AASS

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_005763
Myc/DDK tagged cDNA clone in CMV expression vector: NM_005763
untagged cDNA clone in CMV expression vector: NM_005763

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_005763

UniProtKB/Swiss-Prot: AASS_HUMAN, Q9UDR5

Function: Bifunctional enzyme that catalyzes the first two steps in lysine degradation. The

N-terminal and the C-terminal contain lysine-ketoglutarate reductase and saccharopine

dehydrogenase activity, respectively

Catalytic activity: N(6)-(L-1,3-dicarboxypropyl)-L-lysine + NADP(+) + H(2)O = L-lysine +

2-oxoglutarate + NADPH

Catalytic activity: N(6)-(L-1,3-dicarboxypropyl)-L-lysine + NAD(+) + H(2)O = L-glutamate +

2-aminoadipate 6-semialdehyde + NADH

Induction: Induced by starvation (By similarity)

5 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005488	binding	IEA	--
GO:0009055	electron carrier activity	IEA	--
GO:0016491	oxidoreductase activity	IEA	--
GO:0047130	saccharopine dehydrogenase (NADP+, L-lysine-forming) activity	IEA	--
GO:0047131	saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity	NAS	10775527

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

2 Sigma-Aldrich "Your Favorite Gene" Pathways for AASS (Your Favorite Gene powered by Ingenuity)

Lysine Biosynthesis
Lysine Degradation

GeneDecks AASS for the pathways selected above

About GeneDecksing

UniProtKB/Swiss-Prot: AASS_HUMAN, Q9UDR5

Pathway: Amino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from

L-lysine: step 1/6

Pathway: Amino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from

L-lysine: step 2/6

5 Interacting proteins for AASS (ENSP00000351834³) via UniProtKB, MINT, and/or STRING

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
AASDHPPT	ENSP00000278618³	STRING (score=.976)
SCCPDH	ENSP00000355467³	STRING (score=.961)
KARS	ENSP00000325448³	STRING (score=.899)
SRM	ENSP00000366156³	STRING (score=.802)
BTD	ENSP00000306477³	STRING (score=.8)

About this table

3 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006554	lysine catabolic process	NAS	10775527
GO:0051262	protein tetramerization	TAS	10567240
GO:0055114	oxidation reduction	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for AASS
10/12 Novoseek chemical compound relationships for AASS gene (see all 12 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
saccharopine	97.07	46	9286108 (6), 11080311 (2), 10775527 (2), 17854830 (2) (see all 15)
alpha-aminoadipic semialdehyde	86.73	9	10775527 (3), 9249048 (1)
glyceraldehyde	67.71	3	9513410 (1), 2134294 (1), 12355795 (1)
lysine	63.11	26	11080311 (2), 10775527 (2), 9286108 (2), 18839315 (1) (see all 12)
aldose	50.19	2	12615520 (1), 1748066 (1)
nadh	44.76	8	12962626 (2), 8736155 (1), 11371030 (1), 8885129 (1)
nad+	37.50	6	11080311 (1), 12962626 (1)
fructose	35.80	4	12962626 (1), 8885129 (1)
glycogen	8.65	1	9145586 (1)
atp	8.43	4	9915670 (2), 15284438 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (AASS)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005763

Sigma-Aldrich siRNA and siRNA Panels for AASS

Sigma-Aldrich shRNA for AASS

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_005763

REFSEQ mRNAs for AASS gene:

NM_005763.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_005763

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_005763
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_005763
                                 untagged cDNA clone in CMV expression vector: NM_005763

Additional cDNA sequence:

AF229180.1 AK023446.1 AK225898.1 AK294326.1 BC144246.1 BC144247.1

9 DOTS entries:

DT.97818478 DT.447975 DT.100784090 DT.95261180 DT.92036833 DT.40129587 DT.40274506 DT.91701477

DT.121112877

24/166 AceView cDNA sequences (see all 166 ):

BM669241 BE465730 AA256200 BE326875 AA729905 BF439626 AI634665 W32719

W20467 AW827094 BF109455 AI365151 AA976207 AI651132 AW611933 BE674228

AI912536 AI917478 AI621212 AW006283 BE466144 AJ007714 AI733187 AA485511

highest scoring ESTs for AASS:

AJ007714 AF229180 AI431918 AL699223 AU100512 BX498682 CD654519 CD656282 AA721427 AI022321

Unigene Cluster for AASS:

Aminoadipate-semialdehyde synthase

Hs.156738 [show with all ESTs]

Unigene Representative Sequence: NM_005763

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for AASS (see all 7 )

ExUns:	1a	·	1b	^	2a	·	2b	·	2c	^	3	^	4	^	5	^	6	^	7	^	8	^	9a	·	9b	^	10a	·	10b	^	11	^	12	^	13	^	14	^	15a	·	15b	^	16a	·	16b	^	17	^	18	^	19a	·
SP1:					-																						-						-										-
SP2:																											-						-										-
SP3:
SP4:
SP5:

ExUns:	19b	^	20a	·	20b	^	21a	·	21b	^	22	^	23a	·	23b	^	24	^	25	^	26	^	27a	·	27b
SP1:							-		-								-
SP2:							-		-								-
SP3:
SP4:													-
SP5:

About this scheme

ECgene alternative splicing isoforms for AASS

2 Ensembl transcripts including schematic representations:

ENST00000358954 ENST00000393376

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

AASS expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for AASS

¹ / ² / ³

6 probe-sets matching AASS gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
35870_at²^{, 3}	U95-A	1	1.00	1.00	0.91	0.88	AJ007714	1.00	1.00	1.00	1
91550_r_at²^{, 3}	U95-E	1	1.00	1.00	0.95	1.12	AI431918	0.80	1.00	0.91	1
214829_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AK023446	0.60	1.00	0.82	1
210852_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AF229180	0.80	1.00	0.91	1
214829_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
210852_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: AAAGGCCACA

SOURCE GeneReport for Unigene cluster: Hs.156738
Expression variation in blood from EXPOLDB for AASS
UniProtKB/Swiss-Prot: AASS_HUMAN, Q9UDR5
Tissue specificity: Expressed in all 16 tissues examined with highest expression in the liver

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for AASS gene from 5/18 species (see all 18 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	AASS¹	--	aminoadipate-semialdehyde synthase	86.88(n) 89.89(a)	482429 XM_539546.2 XP_539546.2
chimpanzee (Pan troglodytes)	AASS¹	--	aminoadipate-semialdehyde synthase	99.5(n) 99.68(a)	472493 XM_527868.2 XP_527868.2
cow (Bos taurus)	AASS¹	--	aminoadipate-semialdehyde synthase	89.44(n) 90.38(a)	520865 XM_599115.3 XP_599115.3
rat (Rattus norvegicus)	Aass¹	--	aminoadipate-semialdehyde synthase	79.13(n) 78.95(a)	296925 XM_231524.4 XP_231524.4
mouse (Mus musculus)	Aass^{1, 5}	6 (4.50 cM)⁵	aminoadipate-semialdehyde synthase^{1, 5}	84.68(n)¹ 87.57(a)¹	30956¹ NM_013930.3¹ NP_038958.2¹ AJ224761⁵ AK044323⁵ (see all 12)

About this table Species with no ortholog for AASS

ENSEMBL Gene Tree for AASS

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/274 NCBI SNPs in AASS are shown (see all 274 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 91)

AB	SNP ID	Valid	Chr 7 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs10488107^1,2	C,F,H	121561885(+)	`AGATCA/GTTTTT`	1	--	ng3¹		16		NS EU EA WA NA	1080
	rs1206380^1,2	A,C,F	121503201(+)	`TCTGAC/TTAAAA`	1	--	ut3¹		1		MN	184
--	rs12217^1,2	C,F,H	121501889(+)	`acttaT/Caatat`	1	--	ut3¹		9		MN EU EA WA NA	930
--	rs10246405^1,2	A,C	121562204(+)	`tgtggA/Cacata`	1	--	ng3¹		0	--	--	--	--
	rs10242443^1,2	C,F	121561227(+)	`TAACTG/ACAAAA`	1	--	ng3¹		3		NA	126
--	rs17144072^1,2	H	121506191(+)	`GGCATC/TCAGAA`	1	D/N	mis¹ ese³		5		MN EU EA WA	590
	rs279702^1,2	H	121561018(+)	`GCATCT/CTGACA`	1	--	ut5¹ ese³		8		NA EA MN EU WA	798
--	rs12540216^1,2	C	121501334(+)	`atctgC/Tgcaca`	1	--	ut3¹		0	--	--	--	--
	rs10464523^1,2	H	121526074(+)	`ATATTC/TTAATA`	1	E/K	mis¹		4		EU EA WA	414
--	rs1061742^1,2	C	121503123(-)	`CCTAAG/TTTAAG`	1	--	ut3¹		1		MN	184

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HapMap Linkage Disequilibrium images for AASS (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 605113 disorders: 238700 268700

UniProtKB/Swiss-Prot: AASS_HUMAN, Q9UDR5

Defects in AASS are the cause of hyperlysinemia [MIM:238700]. Hyperlysinemia is an

autosomal recessive condition characterized by hyperlysinemia lysinuria and variable

saccharopinuria

3 Novoseek disease relationships for AASS gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
diabetes mellitus	5.11	2	9513410 (1), 12355795 (1)
ischemia	0.00	2	11021367 (2)
edema	0.00	1	8063356 (1)

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Human Gene Mutation Database: AASS

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/64 PubMed articles for AASS gene (see all 64 ):

Identification of the alpha-aminoadipic semialdehyde synthase gene, which is defective in familial hyperlysinemia. (PubMed id 10775527)^{1, 2, 3, 4} Sacksteder K.A.... Geraghty M.T. (2000)
The DNA sequence of human chromosome 7. (PubMed id 12853948)^{3, 4} Hillier L.W.... Wilson R.K. (2003)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)³ Kimura K.... Sugano S. (2006)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)³ Ota T....Sugano S. (2004)
Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)³ Scherer S.W....Tsui L.C. (2003)
Lysine degradation through the saccharopine pathway in mammals: involvement of both bifunctional and monofunctional lysine-degrading enzymes in mouse. (PubMed id 10567240)³ Papes F....Arruda P. (1999)
Toward a complete human genome sequence. (PubMed id 9847074)³ (1998)
Construction and characterization of a full length-enriched and a 5'- end-enriched cDNA library. (PubMed id 9373149)³ Suzuki Y.... Sugano S. (1997)
Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)³ Bonaldo M.F....Soares M.B. (1996)
Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PubMed id 8125298)³ Maruyama K. and Sugano S. (1994)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 10157	HGNC: 17366	AceView: AASS	Ensembl:ENSG00000008311	euGenes: HUgn10157
ECgene: AASS	H-InvDB: AASS

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
GeneReviews	http://www.genetests.org/query?gene=AASS

Licensable Technologies for AASS
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for AASS:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for AASS-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for AASS		Antibodies for AASS
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for AASS		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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	Custom Service for Rabbit Pab from Full-length Protein

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Search Tocris compounds for AASS

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Search Novus for antibodies for AASS

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AASS Gene

protein-coding GIFtS: 54

Aliases &
Descriptions
for AASS

Summaries
for AASS

Genomic Location
for AASS

Proteins
for AASS

Protein Domains/
Families
for AASS

Gene Function
for AASS

Pathways & Interactions
for AASS

Drugs & Compounds
for AASS

Transcripts
for AASS

Expression
for AASS

Orthologs
for AASS

Paralogs
for AASS

SNPs/Variants
for AASS

Disorders & Mutations
for AASS

Medical News
for AASS

Publications
for AASS

Search for AASS

Genome Databases showing AASS

Other Databases showing AASS

Specialized Databases showing AASS

Licensable Technologies
for AASS

Services
for AASS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

AASS Gene

protein-coding GIFtS: 54

Aliases & Descriptionsfor AASS

Summariesfor AASS

Genomic Locationfor AASS

Proteinsfor AASS

Protein Domains/Familiesfor AASS

Gene Functionfor AASS

Pathways & Interactionsfor AASS

Drugs & Compoundsfor AASS

Transcriptsfor AASS

Expression for AASS

Orthologsfor AASS

Paralogsfor AASS

SNPs/Variantsfor AASS

Disorders & Mutationsfor AASS

Medical Newsfor AASS

Publicationsfor AASS

Search for AASS

Genome Databases showing AASS

Other Databases showing AASS

Specialized Databases showing AASS

Licensable Technologiesfor AASS

Servicesfor AASS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for AASS

Summaries
for AASS

Genomic Location
for AASS

Proteins
for AASS

Protein Domains/
Families
for AASS

Gene Function
for AASS

Pathways & Interactions
for AASS

Drugs & Compounds
for AASS

Transcripts
for AASS

Expression
for AASS

Orthologs
for AASS

Paralogs
for AASS

SNPs/Variants
for AASS

Disorders & Mutations
for AASS

Medical News
for AASS

Publications
for AASS

Licensable Technologies
for AASS

Services
for AASS