AASDH Gene
protein-coding GIFtS : 44
GCID: GC04 M057204
aminoadipate-semialdehyde dehydrogenase
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Aliasesfor AASDH gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Aminoadipate-Semialdehyde Dehydrogenase 1 2 3 Acyl-CoA Synthetase Family Member 42 ACSF41 2 3 Non-Ribosomal Peptide Synthetase 10982 LYS21 2 Non-Ribosomal Peptide Synthetase 9982 NRPS9981 2 EC 6.2.1.-3 2-Aminoadipic 6-Semialdehyde Dehydrogenase2 U263 NRPS10982 Protein NRPS9983
Export aliases for AASDH gene to outside databases Previous GC identifers: GC04M057046 GC04M056899 GC04M053158
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Summariesfor AASDH gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section UniProtKB/Swiss-Prot: ACSF4_HUMAN, Q4L235 Function : Acyl-CoA synthases catalyze the initial reaction in fatty acid metabolism, by forming a thioester with CoA(By similarity)
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Genomic Viewsfor AASDH gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000004.11 NC_018915.1 NT_022853.15 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the AASDH gene promoter: HOXA9B HOXA9 HFH-3 Tal-1beta Meis-1b FOXI1 POU2F1 POU2F1a ITF-2 Meis-1 Other transcription factors Search SABiosciences Chromatin IP Primers for AASDH Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AASDH
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 4q12 Ensembl cytogenetic band: 4q12 HGNC cytogenetic band: 4q12 AASDH Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 4 GeneLoc Exon Structure
GeneLoc location for GC04M057204: view genomic region
(about GC identifiers )
Start:
57,204,456 bp from pter
End:
57,253,666 bp from pter
Size:
49,211 bases
Orientation:
minus strand
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Proteinsfor AASDH gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: ACSF4_HUMAN, Q4L235 (See
protein sequence )Recommended Name: Acyl-CoA synthetase family member 4 Size : 1098 amino acids; 122597 Da
Sequence caution : Sequence=CAH56482.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions : A5D8V3 A5PL22 Q63HK2 Q63HR7 Q6IPP8 Q6TFZ6 Q7Z5Y3 Q96BW4 Q9P064Alternative splicing : 4 isoforms : Q4L235-1 Q4L235-2 Q4L235-3 Q4L235-4 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for AASDH: NX_Q4L235 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q4L235 AASDH Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_861522.2 ENSEMBL proteins: ENSP00000205214 ENSP00000423760 ENSP00000427298 ENSP00000421658 ENSP00000421171 ENSP00000392158 ENSP00000409656 Human Recombinant Protein Products: AASDH Antibody Products: Assay Products for AASDH:
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Protein
Domains / Familiesfor AASDH gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
AASDH for domains About GeneDecksing 5/6 InterPro domains/families (see all 6 ):
Graphical View of Domain Structure for InterPro Entry Q4L235 ProtoNet protein and cluster: Q4L235
2 Blocks protein families : IPB000873 AMP-binding signature IPB002372 Bacterial quinoprotein UniProtKB/Swiss-Prot: ACSF4_HUMAN, Q4L235 Similarity : Belongs to the ATP-dependent AMP-binding enzyme familySimilarity : Contains 1 acyl carrier domain
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Functionfor AASDH gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: ACSF4_HUMAN, Q4L235 Function : Acyl-CoA synthases catalyze the initial reaction in fatty acid metabolism, by forming a thioester with CoA(By similarity) Enzyme Number (IUBMB): EC 6.2.1.- 1
Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for AASDH (see all 2 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for AASDHOriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: AASDH (NM_015423 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for AASDH Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat AASDH
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AASDH
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view) : About this table
AASDH for ontologies About GeneDecksing
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Pathways & Interactionsfor AASDH gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for AASDH Gene Ontology (GO): 1 biological process term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0006631 fatty acid metabolic process
ISS --
AASDH for ontologies About GeneDecksing
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Drugs & Compoundsfor AASDH gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for AASDH 10/44 HMDB Compounds for AASDH (see all 44 ) About this table Search CenterWatch for drugs/clinical trials and news about AASDH / ACSF4
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Transcriptsfor AASDH gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
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microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
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SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for AASDH gene: NM_181806.2 Unigene Cluster for AASDH:
Aminoadipate-semialdehyde dehydrogenase Hs.104347 [show with all ESTs ] Unigene Representative Sequence: BX640635 10 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000205214 (uc003hbn.3 uc003hbo.3 uc011caa.2 uc011cab.2 uc010ihc.3 )ENST00000513376 (uc010ihb.3 ) ENST00000514745 ENST00000503808 ENST00000502617 (uc003hbp.3 )ENST00000510762 ENST00000510012 (uc003hbq.1 ) ENST00000514796 ENST00000434343 ENST00000451613 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for AASDH (see all 2 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for AASDHOriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: AASDH (NM_015423 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for AASDH Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat AASDH
Additional cDNA sequence: AF161436.1 AF516672.1 AK294332.1 AK303733.1 AK304309.1 AK316296.1 AY314787.1 AY422212.1 BC071815.1 BC141824.1 BC142709.1 BX640635.1 BX648853.1
8 DOTS entries : DT.102840635 DT.204921
DT.409599 DT.100020415 DT.91845353 DT.97802636 DT.99990104 DT.91995962 24/88 AceView cDNA sequences (see all 88 ):
AI057495 AA242893 BX116011 AA242754 CA389655 BE222228 AI498469 BC015096 AI291045 AA251083 BQ778385 BF433048 AI192755 CA412591 BU681512 BM142306 AI278261 NM_181806 AI768136 AI863222 AA972283 AA312080 AA453778 BM787517 GeneLoc Exon Structure
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Expression for AASDH gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section AASDH expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: TGGACTTATT
About this image See AASDH Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for AASDH SOURCE GeneReport for Unigene cluster: Hs.104347 UniProtKB/Swiss-Prot: ACSF4_HUMAN, Q4L235 Tissue specificity : Ubiquitously expressed in adult tissues SABiosciences Custom PCR Arrays for AASDH Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for AASDHBrowse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat AASDH QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat AASDH QIAGEN QuantiFast Probe-based Assays in human , mouse , rat AASDH In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AASDH
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Orthologsfor AASDH gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the last universal common ancestor (LUCA).
Orthologs for AASDH gene from 10/31 species (see all 31 ) About this table
ENSEMBL Gene Tree for AASDH (if available)TreeFam Gene Tree for AASDH (if available)
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Paralogsfor AASDH gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section --
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Genomic Variantsfor AASDH gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing AASDH
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Disorders
/ Diseasesfor AASDH gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
AASDH for disorders About GeneDecksing
OMIM gene information: 614365
OMIM disorders : --3 diseases for AASDH : About MalaCards pneumonia tuberculosis mycobacterium tuberculosis Export disorders for AASDH gene to outside databases
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Publicationsfor AASDH gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for AASDH gene, integrated from 9 sources (see all 11 ): (articles sorted by number of sources associating them with AASDH) Utopia : connect your pdf to the dynamic world of online information
Cloning and characterization of a novel human homolog of mouse U26, a putative PQQ-dependent AAS dehydrogenase. (PubMed id 15865210) 1 , 2 , 3, 9 Wang L.... Mao Y. (2005) Evidence for 26 distinct acyl-coenzyme A synthetase genes in the human genome. (PubMed id 17762044) 1 , 3 Watkins P.A.... Pevsner J. (2007) Nutritional biochemistry: A new redox-cofactor vitamin for mammals. (PubMed id 12712191) 1 , 3 Kasahara T. and Kato T. (2003) System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692) 2 Rigbolt K.T....Blagoev B. (2011) The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005) 2 Bechtel S.... Schupp I. (2007) Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621) 2 Hillier L.W....Wilson R.K. (2005) SMART amplification combined with cDNA size fractionation in order to obtain large full-length clones. (PubMed id 15198809) 1 Wellenreuther R....The German cDNA Consortium (2004) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 2 Gerhard D.S....Malek J. (2004) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 Strausberg R.L....Marra M.A. (2002) Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166) 1 Wiemann S.... Poustka A. (2001)
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External Searches for AASDH gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing AASDH gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing AASDH gene
(According to HUGE )
About This Section --
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Specialized Databases showing AASDH gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for AASDH Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for AASDH gene: Search GeneIP for patents involving AASDH GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor AASDH gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for AASDH OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for AASDH OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for AASDH OriGene Protein Over-expression Lysate for AASDH Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for AASDH OriGene 3'-UTR Clone for AASDH OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for AASDH OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for AASDH Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for AASDH OriGene Custom Protein Services for AASDH OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat AASDH QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing AASDH QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AASDH QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat AASDH QIAGEN QuantiFast Probe-based Assays in human , mouse , rat AASDH QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat AASDH
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AASDH Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AASDH
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Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat AASDH
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