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Aliases for AASDH Gene

Aliases for AASDH Gene

  • Aminoadipate-Semialdehyde Dehydrogenase 2 3 4
  • ACSF4 3 4 6
  • Acyl-CoA Synthetase Family Member 4 2 3
  • 2-Aminoadipic 6-Semialdehyde Dehydrogenase 3
  • Non-Ribosomal Peptide Synthetase 1098 3
  • Non-Ribosomal Peptide Synthetase 998 3
  • Protein NRPS998 4
  • EC 6.2.1.- 4
  • NRPS1098 3
  • NRPS998 3
  • LYS2 3
  • U26 4

External Ids for AASDH Gene

Previous GeneCards Identifiers for AASDH Gene

  • GC04M057046
  • GC04M056899
  • GC04M057204
  • GC04M053158

Summaries for AASDH Gene

GeneCards Summary for AASDH Gene

AASDH (Aminoadipate-Semialdehyde Dehydrogenase) is a Protein Coding gene. GO annotations related to this gene include acid-thiol ligase activity.

UniProtKB/Swiss-Prot for AASDH Gene

  • Acyl-CoA synthases catalyze the initial reaction in fatty acid metabolism, by forming a thioester with CoA.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AASDH Gene

Genomics for AASDH Gene

Regulatory Elements for AASDH Gene

Genomic Location for AASDH Gene

Start:
56,338,284 bp from pter
End:
56,387,698 bp from pter
Size:
49,415 bases
Orientation:
Minus strand

Genomic View for AASDH Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for AASDH Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AASDH Gene

Proteins for AASDH Gene

  • Protein details for AASDH Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q4L235-ACSF4_HUMAN
    Recommended name:
    Acyl-CoA synthetase family member 4
    Protein Accession:
    Q4L235
    Secondary Accessions:
    • A5D8V3
    • A5PL22
    • Q63HK2
    • Q63HR7
    • Q6IPP8
    • Q6TFZ6
    • Q7Z5Y3
    • Q96BW4
    • Q9P064

    Protein attributes for AASDH Gene

    Size:
    1098 amino acids
    Molecular mass:
    122597 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAH56482.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for AASDH Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AASDH Gene

Proteomics data for AASDH Gene at MOPED

Post-translational modifications for AASDH Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for AASDH Gene

Domains for AASDH Gene

Gene Families for AASDH Gene

HGNC:
  • ACS :Acyl-CoA synthetase family

Suggested Antigen Peptide Sequences for AASDH Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q4L235

UniProtKB/Swiss-Prot:

ACSF4_HUMAN :
  • Q4L235
Domain:
  • Contains 1 acyl carrier domain.
Family:
  • Belongs to the ATP-dependent AMP-binding enzyme family.
genes like me logo Genes that share domains with AASDH: view

Function for AASDH Gene

Molecular function for AASDH Gene

UniProtKB/Swiss-Prot Function:
Acyl-CoA synthases catalyze the initial reaction in fatty acid metabolism, by forming a thioester with CoA.

Enzyme Numbers (IUBMB) for AASDH Gene

Gene Ontology (GO) - Molecular Function for AASDH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0005524 ATP binding IEA --
GO:0016878 acid-thiol ligase activity ISS --
genes like me logo Genes that share ontologies with AASDH: view

Animal Model Products

CRISPR Products

miRNA for AASDH Gene

miRTarBase miRNAs that target AASDH

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for AASDH

In Situ Assay Products

Flow Cytometry Products

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for AASDH Gene

Localization for AASDH Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AASDH Gene COMPARTMENTS Subcellular localization image for AASDH gene
Compartment Confidence
cytosol 2
nucleus 2
peroxisome 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for AASDH Gene

Pathways for AASDH Gene

SuperPathways for AASDH Gene

No Data Available

Interacting Proteins for AASDH Gene

Gene Ontology (GO) - Biological Process for AASDH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006631 fatty acid metabolic process ISS --
GO:0008152 metabolic process --
genes like me logo Genes that share ontologies with AASDH: view

No data available for Pathways by source for AASDH Gene

Compounds for AASDH Gene

(44) HMDB Compounds for AASDH Gene

Compound Synonyms Cas Number PubMed IDs
(2E)-Decenoyl-CoA
  • (E)-S-2-decenoate Coenzyme A
10018-95-8
(2E)-Dodecenoyl-CoA
  • 2-trans-Dodecenoyl-Coenzyme A
1066-12-2
(2E)-Hexadecenoyl-CoA
  • trans-2-Hexadecenoyl-CoA
4460-95-1
(2E)-Octenoyl-CoA
  • (E)-S-2-octenoate Coenzyme A
10018-94-7
(2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-Coenzyme A
38795-33-4
genes like me logo Genes that share compounds with AASDH: view

Transcripts for AASDH Gene

Unigene Clusters for AASDH Gene

Aminoadipate-semialdehyde dehydrogenase:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for AASDH

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for AASDH Gene

No ASD Table

Relevant External Links for AASDH Gene

GeneLoc Exon Structure for
AASDH
ECgene alternative splicing isoforms for
AASDH

Expression for AASDH Gene

mRNA expression in normal human tissues for AASDH Gene

Protein differential expression in normal tissues for AASDH Gene

This gene is overexpressed in Heart (50.5) and Plasma (13.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for AASDH Gene

SOURCE GeneReport for Unigene cluster for AASDH Gene Hs.104347

mRNA Expression by UniProt/SwissProt for AASDH Gene

Q4L235-ACSF4_HUMAN
Tissue specificity: Ubiquitously expressed in adult tissues.
genes like me logo Genes that share expressions with AASDH: view

Expression partners for AASDH Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for AASDH Gene

Orthologs for AASDH Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for AASDH Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia AASDH 35
  • 88.2 (n)
  • 83.94 (a)
AASDH 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AASDH 35
  • 89.32 (n)
  • 85.9 (a)
AASDH 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Aasdh 35
  • 77.64 (n)
  • 73.24 (a)
Aasdh 16
Aasdh 36
  • 73 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia AASDH 35
  • 99.76 (n)
  • 99.54 (a)
AASDH 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Aasdh 35
  • 77.76 (n)
  • 72.41 (a)
oppossum
(Monodelphis domestica)
Mammalia AASDH 36
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia AASDH 36
  • 55 (a)
OneToOne
chicken
(Gallus gallus)
Aves AASDH 35
  • 66.18 (n)
  • 58.88 (a)
AASDH 36
  • 57 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia AASDH 36
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia aasdh 35
  • 58.09 (n)
  • 52.5 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.3073 35
zebrafish
(Danio rerio)
Actinopterygii aasdh 35
  • 52.34 (n)
  • 47.09 (a)
aasdh 36
  • 40 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010071 35
  • 38.79 (n)
  • 23.41 (a)
fruit fly
(Drosophila melanogaster)
Insecta U26 35
  • 44.11 (n)
  • 34.38 (a)
U26 36
  • 27 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C41A3.1 36
  • 2 (a)
OneToMany
W09D6.1 36
  • 11 (a)
OneToMany
Y66D12A.14 36
  • 8 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes LYS2 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G35930 35
  • 43.55 (n)
  • 31.77 (a)
rice
(Oryza sativa)
Liliopsida Os06g0111600 35
  • 45.11 (n)
  • 31.29 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.702 35
Species with no ortholog for AASDH:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for AASDH Gene

ENSEMBL:
Gene Tree for AASDH (if available)
TreeFam:
Gene Tree for AASDH (if available)

Paralogs for AASDH Gene

No data available for Paralogs for AASDH Gene

Variants for AASDH Gene

Sequence variations from dbSNP and Humsavar for AASDH Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs8340 - 56,338,611(-) ATAAC(G/T)ACAAT missense, reference, utr-variant-3-prime
rs1124569 -- 56,369,958(-) ttttt(G/T)ttttt intron-variant
rs1124570 -- 56,369,957(-) ttttt(G/T)ttttt intron-variant
rs1850925 -- 56,386,712(+) GGCGT(C/G)AACCC intron-variant, upstream-variant-2KB
rs1983377 -- 56,382,836(+) AGGTT(C/G)AGGCG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for AASDH Gene

Variant ID Type Subtype PubMed ID
nsv829940 CNV Gain 17160897

Relevant External Links for AASDH Gene

HapMap Linkage Disequilibrium report
AASDH

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AASDH Gene

Disorders for AASDH Gene

No disorders were found for AASDH Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for AASDH Gene

Publications for AASDH Gene

  1. Cloning and characterization of a novel human homolog of mouse U26, a putative PQQ-dependent AAS dehydrogenase. (PMID: 15865210) Wang L. … Mao Y. (Mol. Biol. Rep. 2005) 2 3 4 23
  2. Nutritional biochemistry: A new redox-cofactor vitamin for mammals. (PMID: 12712191) Kasahara T. … Kato T. (Nature 2003) 2 3
  3. Evidence for 26 distinct acyl-coenzyme A synthetase genes in the human genome. (PMID: 17762044) Watkins P.A. … Pevsner J. (J. Lipid Res. 2007) 2 3
  4. Vertebrate AcylA CoA synthetase family memberA 4 (ACSF4-U26) is a I^-alanine-activating enzyme homologous to bacterial non-ribosomal peptide synthetase. (PMID: 24467666) Drozak J. … Van Schaftingen E. (FEBS J. 2014) 3
  5. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 4

Products for AASDH Gene

Sources for AASDH Gene

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