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AARSD1 Gene

protein-coding   GIFtS: 49

GC17M038357
alanyl-tRNA synthetase domain containing 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
MGC2744 1, 2
Descriptions
alanyl-tRNA synthetase domain containing 1 2
External Ids
HGNC: 284171
Entrez Gene: 807552
UniProtKB: Q9BTE63
Ensembl: ENSG000001088257
Search outside databases for aliases for AARSD1 gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

  --
(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the AARSD1 gene  

Entrez Gene cytogenetic band: 17q21.31   Ensembl cytogenetic band:  17q21.31   HGNC cytogenetic band: 17q21.31

AARSD1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M038357:     (about GC identifiers)

Start:
38,356,069 bp from pter
End:
38,386,033 bp from pter
Size:
29,965 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000017.9  NT_010755.15  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: AASD1_HUMAN, Q9BTE6 (See protein sequence)
Recommended Name: Alanyl-tRNA synthetase domain-containing protein 1  
Size: 412 amino acids; 45480 Da
Alternative splicing: 2 isoforms:  Q9BTE6-1   Q9BTE6-2   

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins (4 alternative transcripts): 
    NP_001129514.2  NP_001136125.1  NP_001136126.1  NP_079543.1  


    ENSEMBL proteins: 
    ENSP00000386254 ENSP00000386902 ENSP00000353355 ENSP00000386621 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse Abcam for Recombinant Proteins
    Human Recombinant Proteins from Abnova (AARSD1)
                  OriGene Purified Recombinant Human Protein: AARSD1 

    1 Gene Ontology (GO) cellular component term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737 cytoplasm IEA--
    About this table

    Antibodies for AARSD1: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for AARSD1
    Browse R&D Systems for Antibodies
    Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
    Monoclonal and Polyclonal Antibodies from Abnova (AARSD1)
    Novus Biologicals Antibody for AARSD1

    Assays for AARSD1: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    2 InterPro domains/families:
     IPR012947 tRNA_SAD
     IPR018165 Ala-tRNA-synth_IIc_cons-reg


       GeneDecks  AARSD1 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q9BTE6

    ProtoNet protein and cluster: Q9BTE6

    UniProtKB/Swiss-Prot: AASD1_HUMAN, Q9BTE6
    Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. AARSD1 subfamily

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (AARSD1)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_025267

                  Applied Biosystems Silencer® siRNAs for AARSD1

                  Sigma-Aldrich siRNA for AARSD1  
                         Sigma-Aldrich shRNA for AARSD1  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for AARSD1
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): NM_001136042
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): NM_001136042
                                     untagged cDNA clones in CMV expression vector (see all 4): NM_001136042 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_001136042

    5 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166 nucleotide binding IEA--
    GO:0003676 nucleic acid binding IEA--
    GO:0004813 alanine-tRNA ligase activity IEA--
    GO:0005524 ATP binding IEA--
    GO:0016876 ligase activity, forming aminoacyl-tRNA and related compounds IEA--
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


    2 Sigma-Aldrich "Your Favorite Gene" Pathways for  AARSD1  (Your Favorite Gene powered by Ingenuity) 
     Aminoacyl-tRNA Biosynthesis
     Alanine and Aspartate Metabolism

       GeneDecks  AARSD1 for the pathways selected above  
    About GeneDecksing


    2 Interacting proteins for AARSD1 (ENSP000003533553) via UniProtKB, MINT, and/or STRING
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MRI1ENSP000000406633STRING (score=.712)
    LACTB2ENSP000002765903STRING (score=.706)
    About this table

    3 Gene Ontology (GO) biological process terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006412 translation IEA--
    GO:0006419 alanyl-tRNA aminoacylation IEA--
    GO:0043039 tRNA aminoacylation IEA--
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for AARSD1

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (AARSD1)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_025267

                  Sigma-Aldrich siRNA for AARSD1  
                         Sigma-Aldrich shRNA for AARSD1  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_001136042  NM_001142653  NM_001142654  NM_025267  

    REFSEQ mRNAs for AARSD1 gene (4 alternative transcripts): 

    NM_001136042.2   NM_001142653.1   NM_001142654.1   NM_025267.3   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_001136042  NM_001142653  NM_001142654  NM_025267  

                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): NM_001136042
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): NM_001136042
                                     untagged cDNA clones in CMV expression vector (see all 4): NM_001136042 

    Additional cDNA sequence: 

    AK056965.1 AK094084.1 AK295447.1 BC004172.2 BC019324.1 CR608238.1 CR613084.1 CR617160.1 
    CR619011.1 CR621048.1 

    24/25 DOTS entries (see all 25 ):

    DT.455480  DT.100782335  DT.100782338  DT.120991248  DT.95271937  DT.92433390  DT.311916  DT.99927608 
    DT.306808  DT.100782337  DT.86852121  DT.92433393  DT.91940316  DT.95271935  DT.95324043  DT.100638559 
    DT.120991209  DT.120991216  DT.120991219  DT.120991254  DT.40131627  DT.91843276  DT.92433386  DT.95271951 

    24/223 AceView cDNA sequences (see all 223 ):

    AI671153 BF588584 AI680102 CR619011 BM714928 BM767505 AA315994 CR608238 
    BE465035 AI275613 AI698559 AL539434 AW296090 BC019324 BM803564 BQ278878 
    CD368831 BM827274 BX406721 AI140327 AI669256 CR617160 W81432 BC004172 

    highest scoring ESTs for AARSD1:

    AF039235 AA180872 AK056965 AK094084 AW245514 BC004172 BC019324 AA040597 AA249437 AA359868 

    Unigene Cluster for AARSD1:

    Alanyl-tRNA synthetase domain containing 1
    Hs.317403  [show with all ESTs]
    Unigene Representative Sequence: NM_001136042


    GeneLoc Exon Structure

    5/11 Alternative Splicing Database (ASD) splice patterns (SP) for AARSD1 (see all 11 )

    ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14a · 14b · 14c ^
    SP1:              -                 -                             -                 -     -     -                                                               
    SP2:                                                              -                                                                                             
    SP3:                                            -                 -                                                                                             
    SP4:                                                              -                                                                                             
    SP5:                                                                                                                                                            

    ExUns: 15a · 15b ^ 16 ^ 17
    SP1:                        
    SP2:                        
    SP3:                        
    SP4:                        
    SP5:                        

    About this scheme

    ECgene alternative splicing isoforms for AARSD1

    4 Ensembl transcripts including schematic representations:
    ENST00000409103  ENST00000409446  ENST00000360221  ENST00000409399  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    AARSD1 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for AARSD1

    1 / 2 / 3

    6 probe-sets matching AARSD1 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    53966_at2, 3 U95-B 3 1.00 0.93 0.77 1.20 AF039235 1.00 1.00 1.00 1
    53586_at2, 3 U95-C 1 0.94 1.00 0.99 0.82 AA180872 0.80 1.00 0.91 1

    238740_at2, 3 U133-B 1 1.00 1.00 -- -- AA180872 0.80 1.00 0.91 1

    222064_s_at2, 3 U133-A 3 1.00 0.85 -- -- AI093187 0.40 1.00 0.76 1

    238740_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    222064_s_at2 U133Plus2 3 1.00 0.85 -- -- -- -- -- -- --
    GeneDecks  AARSD1 for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: GAACTGAAAA

    SOURCE GeneReport for Unigene cluster: Hs.317403
    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for AARSD1 gene from 5/13 species (see all 13 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    AARSD11   -- alanyl-tRNA synthetase domain containing 1 89.46(n)
    92.57(a)
    480510  XM_537630.2  XP_537630.2 
    chimpanzee
    (Pan troglodytes)
    AARSD11   -- alanyl-tRNA synthetase domain containing 1 93.9(n)
    92.57(a)
    454704  XM_001157692.1  XP_001157692.1 
    cow
    (Bos taurus)
    MGC1340041   -- similar to CG10802-PA 90.5(n)
    90.75(a)
    510711  NM_001038073.1  NP_001033162.1 
    rat
    (Rattus norvegicus)
    Aarsd11   -- alanyl-tRNA synthetase domain containing 1 88.08(n)
    89.5(a)
    619440  NM_001034109.1  NP_001029281.1 
    mouse
    (Mus musculus)
    Aarsd11, 5 115
    alanyl-tRNA synthetase domain containing 11, 5 87.75(n)1
    89.75(a)1
    696841  NM_144829.11  NP_659078.11 
     AA5896005  AK0098085  (see all 14)
    About this table        Species with no ortholog for AARSD1

    ENSEMBL Gene Tree for AARSD1
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for AARSD1 gene
    PTGES32  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/213 NCBI SNPs in AARSD1 are shown (see all 213 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 57)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 17 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs13979511,2
    H38374492(+) TGCATC/TTGATG 3 -- ut31 int15Minor allele frequency- T:0.02MN EU EA WA 604
    --
    rs115513301,2
    H38362021(+) ATTGAC/TGCTCT 2 V/I mis1 ese34Minor allele frequency- T:0.00EU EA WA 406
    rs7273621,2
    H38374385(-) GTATGT/GGGCAA 3 -- ut31 int15Minor allele frequency- G:0.00MN EU EA WA 604
    rs23559531,2
    H38374636(+) GCTTTC/TTAGAA 3 -- ut31 int14Minor allele frequency- T:0.00EU EA WA 418
    rs13979521,2
    H38374562(+) AGCTTC/TTAGGA 3 -- ut31 int15Minor allele frequency- T:0.00MN EU EA WA 604
    rs6909411,2
    A,C,F,H38369760(+) CAGCAA/GGAGAC 2 S/S syn16Minor allele frequency- G:0.08MN EU EA WA NA 664
    rs72125641,2
    A,C,F,H38360811(+) CAGTCG/ATTTCT 1 -- int14Minor allele frequency- A:0.06EU EA WA 412
    rs65037211,2
    A,C,F,H38380974(+) TTGCAG/AAACAA 1 -- int14Minor allele frequency- A:0.34EU EA WA 414
    rs80647831,2
    A,C,F,H38375814(+) GTTGAG/AGGGAA 1 -- int1 trp34Minor allele frequency- A:0.05EU EA WA 418
    rs22925391,2
    A,C,F,O38357638(-) TTCACT/CTAAGT 1 -- int13Minor allele frequency- C:0.34NA 142
    About this table

    HapMap Linkage Disequilibrium images for AARSD1 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

      --

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    7 PubMed articles for AARSD1 gene:
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 80755 HGNC: 28417 AceView: MGC2744 Ensembl:ENSG00000108825 euGenes: HUgn80755
    ECgene: AARSD1 H-InvDB: AARSD1
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

      --
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for AARSD1:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
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      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for AARSD1-related products

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     Predesigned and custom siRNAs for AARSD1 Antibodies for AARSD1
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for AARSD1 Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
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     Search Tocris compounds for AARSD1




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