 |
 | Services
| |
 |
Aliases & Descriptions for AARS
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| AlaRS 3 | | EC 6.1.1.7 3 |
| | | Descriptions |
|---|
| Alanine--tRNA ligase 3 | | Renal carcinoma antigen NY-REN-42 3 | | alanine tRNA ligase 1, cytoplasmic 2 | | alanyl-tRNA synthetase 2 |
|
| | Search outside databases for aliases for AARS genePrevious GC identifers: GC16M060988 GC16M070706 GC16M070021 GC16M070062 |
Summaries for AARS(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for AARS: The human alanyl-tRNA synthetase (AARS) belongs to a family of tRNA synthases, of the class II enzymes. Class II tRNA synthases evolved early in evolution and are highly conserved. This is reflected by the fact that 498 of the 968-residue polypeptide human AARS shares 41% identity witht the E.coli protein. tRNA synthases are the enzymes that interpret the RNA code and attach specific aminoacids to the tRNAs that contain the cognate trinucleotide anticodons. They consist of a catalytic domain which interacts with the amino acid acceptor-T psi C helix of the tRNA, and a second domain which interacts with the rest of the tRNA structure. [provided by RefSeq]
|
Genomic Location for AARS
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the AARS gene 
Entrez Gene cytogenetic band: 16q22 Ensembl cytogenetic band: 16q22.1 HGNC cytogenetic band: 16q22AARS Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16M068843:
(about GC identifiers)
Start:
|
68,843,798 bp from pter |
End:
|
68,880,913 bp from pter |
Size:
|
37,116 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000016.8 NT_010498.15
| Proteins for AARS
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: SYAC_HUMAN, P49588 (See
protein sequence)Recommended Name: Alanyl-tRNA synthetase, cytoplasmic Size: 968 amino acids; 106810 Da
Subunit: Monomer
Subcellular location: Cytoplasm (Potential)
Secondary accessions: A6NF14 Q53GV7 Q96FA0Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_001596.2
ENSEMBL proteins: ENSP00000261772
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
2 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for AARS: Assays for AARS: | Protein
Domains/ Families for AARS(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry P49588
ProtoNet protein and cluster: P49588 2 Blocks protein families: IPB002318 Alanyl-tRNA synthetase signature IPB003156 Phosphoesterase
UniProtKB/Swiss-Prot: SYAC_HUMAN, P49588Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family | Gene Function for AARS
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001605
Applied Biosystems Silencer® siRNAs for AARS
Sigma-Aldrich siRNA for AARS  Sigma-Aldrich shRNA for AARS  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001605                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_001605                                  untagged cDNA clone in CMV expression vector: NM_001605 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_001605
UniProtKB/Swiss-Prot: SYAC_HUMAN, P49588Catalytic activity: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala)Enzyme Number (IUBMB): EC 6.1.1.7 Genatlas biochemistry entry for AARS:alanyl-tRNA synthetase,target autoantibodies in the immune disease polymyositis/dermatomyositis3 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Aars):
5/6 Gene Ontology (GO) molecular function terms (links to tree view) (see all 6
): About this table | Pathways & Interactions for AARS
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| 2 Sigma-Aldrich "Your Favorite Gene" Pathways for AARS (Your Favorite Gene powered by Ingenuity) 
5/24 Interacting proteins for AARS (ENSP000002617723 P495882) via UniProtKB, MINT, and/or STRING (see all 24
)About this table
5/12 Gene Ontology (GO) biological process terms (links to tree view) (see all 12
): About this table
|
Drugs & Compounds for AARS(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for AARS 5 Novoseek chemical compound relationships for AARS gene
| Compound |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| aminoacyl-trna |
94.06 |
29 |
8286437 (1), 9358165 (1), 11310981 (1), 12421319 (1) (see all 23) |
| trna |
85.61 |
57 |
17704131 (3), 12554667 (2), 18437305 (2), 17726052 (2) (see all 25) |
| anticodon |
73.68 |
5 |
8286437 (1), 11310981 (1), 18611382 (1), 18322459 (1) |
| smpb |
72.91 |
2 |
11904185 (1), 16381838 (1) |
| atp |
0.00 |
2 |
8422978 (1) |
About this table
|
Transcripts for AARS(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001605
Sigma-Aldrich siRNA for AARS  Sigma-Aldrich shRNA for AARS  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_001605 REFSEQ mRNAs for AARS gene: NM_001605.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_001605               OriGene GFP tagged cDNA clone in CMV expression vector: NM_001605                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_001605                                  untagged cDNA clone in CMV expression vector: NM_001605  Additional cDNA sequence: AK222824.1 AK225116.1 AK299098.1 AK307782.1 BC011451.1 D32050.1 22 DOTS entries: DT.448485 DT.95262752 DT.100774719 DT.95262736 DT.95262747 DT.95262749 DT.428242 DT.95262734 DT.100034176 DT.100834181 DT.120712453 DT.40115644 DT.40115645 DT.80100249 DT.91960082 DT.92454788 DT.92454789 DT.95090763 DT.95262748 DT.99987249 DT.120712433 DT.91904558 24/635 AceView cDNA sequences (see all 635
):BI258486 BQ933535 BQ058121 CD724013 BM472171 CD515330 BX423230 BP357328 BU541395 BM806818 BF794496 AI567786 AA099496 AL135343 BP357908 BQ057450 BU782759 BQ682930 BE897229 D32050 AW087287 BM756898 BQ682132 BG177128
highest scoring ESTs for AARS:D32050 AA135099 AL120911 AL515873 AL525814 AU098908 AU133772 AU143575 AW249176 AW500508 Unigene Cluster for AARS: Alanyl-tRNA synthetase Hs.315137 [show with all ESTs]Unigene Representative Sequence: AK222824
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for AARS (see all 6
)
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | ^ | 13a | · | 13b | · | 13c | ^ | 14 | ^ | 15a | · | 15b | ^ | 16 | ^ | 17a | · | 17b | ^ | 18 | ^ | 19 | ^ | 20a | · | 20b | ^ | |
| SP1: | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |
| SP2: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | - |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
| ExUns: | 21 | ^ | 22a | · | 22b | |
| SP1: | |   | |   | |   | |
| SP2: | |   | |   | |   | |
| SP3: | |   | |   | |   | |
| SP4: | |   | |   | |   | |
| SP5: | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for AARS
1 Ensembl transcript including schematic representation: ENST00000261772
|
Expression for AARS
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| AARS expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for AARS
1 / 2 / 3 3 probe-sets matching AARS gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: CTCTTCACGG
SOURCE GeneReport for Unigene cluster: Hs.315137
Expression variation in blood from EXPOLDB for AARS |
Orthologs for AARS
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for AARS gene from 5/26 species (see all 26
)
About this table Species with no ortholog for AARS
ENSEMBL Gene Tree for AARS | Paralogs for AARS(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for AARS gene
- AARS22
|
SNPs/Variants for AARS(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for AARS (up to first 250kb)
|
Disorders & Mutations for AARS
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 601065
2 Novoseek disease relationships for AARS gene
About this table
Human Gene Mutation Database: AARS
|
Medical News for AARS(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for AARS (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/85 PubMed articles for AARS gene (see all 85
):- Human alanyl-tRNA synthetase: conservation in evolution of catalytic core and microhelix recognition. (PubMed id 7654687)1, 3, 4 Shiba K....Schimmel P. (1995)
- Localization of two human autoantigen genes by PCR screening and in situ hybridization--glycyl-tRNA synthetase locates to 7p15 and alanyl-tRNA synthetase locates to 16q22. (PubMed id 8595897)1, 2, 3 Nichols R.C....Liu P. (1995)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)3, 4 Olsen J.V....Mann M. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Antigens recognized by autologous antibody in patients with renal-cell carcinoma. (PubMed id 10508479)3, 4 Scanlan M.J....Old L.J. (1999)
- Wide cross-species aminoacyl-tRNA synthetase replacement in vivo: yeast cytoplasmic alanine enzyme replaced by human polymyositis serum antigen. (PubMed id 7761427)1, 3 Ripmaster T.L....Schimmel P. (1995)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)4 Dephoure N.... Gygi S.P. (2008)
- The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)4 Martin J.... Pennacchio L.A. (2004)
- Interaction network of human aminoacyl-tRNA synthetases and subunits of elongation factor 1 complex. (PubMed id 11829477)3 Sang Lee J....Kim S. (2002)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)3 Strausberg R.L....Marra M.A. (2002)
|
Search for AARS
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing AARS
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing AARS
(According to HUGE)
About This Section
| -- |
Specialized Databases showing AARS(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for AARS(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for AARS:

 | |
 | | | | |
|
 |  |  |
| | | | Search Tocris compounds for AARS |
|
 |
 | | | |
GeneCards Homepage - Last full update: 1 Jul 2009
Incremental update: 13 Oct 2009
|