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Aliases for AARD Gene

Aliases for AARD Gene

  • Alanine And Arginine Rich Domain Containing Protein 2 3 5
  • Alanine And Arginine-Rich Domain-Containing Protein 2 3
  • C8orf85 3 4
  • Chromosome 8 Open Reading Frame 85 2

External Ids for AARD Gene

Previous HGNC Symbols for AARD Gene

  • C8orf85

Previous GeneCards Identifiers for AARD Gene

  • GC08P117951

Summaries for AARD Gene

GeneCards Summary for AARD Gene

AARD (Alanine And Arginine Rich Domain Containing Protein) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AARD Gene

Genomics for AARD Gene

Regulatory Elements for AARD Gene

Enhancers for AARD Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08F116937 0.4 ENCODE 26.7 +0.2 166 1.1 CBX3 SIN3A RAD21 YY1 RARA GLIS2 CREM EGR2 ZNF263 NR2F2 AARD GC08M116935
GH08F116912 0.6 ENCODE 11.4 -25.3 -25323 0.1 CTCF IKZF1 NFYC ZNF644 RAD21 AARD SLC30A8 PIR55072
GH08F116454 0.8 FANTOM5 Ensembl 11.4 -483.7 -483727 0.9 FOXP2 AARD LOC105375711 GC08M116592
GH08F116915 0.4 ENCODE 11.3 -21.7 -21679 1.4 ELF3 JUNB RAD21 YY1 RARA NR2F2 JUND ATF3 HNF4G ZBTB33 AARD SLC30A8 RAD21 PIR55072
GH08F117028 0.5 FANTOM5 11.3 +90.2 90205 0.3 TBX21 SLC30A8 AARD RN7SL228P ENSG00000253271
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around AARD on UCSC Golden Path with GeneCards custom track

Promoters for AARD Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001399586 202 1199 CBX3 SIN3A RAD21 YY1 RARA GLIS2 CREM EGR2 ZNF263 NR2F2

Genomic Location for AARD Gene

Chromosome:
8
Start:
116,938,199 bp from pter
End:
116,944,487 bp from pter
Size:
6,289 bases
Orientation:
Plus strand

Genomic View for AARD Gene

Genes around AARD on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AARD Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AARD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AARD Gene

Proteins for AARD Gene

  • Protein details for AARD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q4LEZ3-AARD_HUMAN
    Recommended name:
    Alanine and arginine-rich domain-containing protein
    Protein Accession:
    Q4LEZ3
    Secondary Accessions:
    • A5PKU8

    Protein attributes for AARD Gene

    Size:
    155 amino acids
    Molecular mass:
    17575 Da
    Quaternary structure:
    No Data Available

neXtProt entry for AARD Gene

Post-translational modifications for AARD Gene

No Post-translational modifications

Other Protein References for AARD Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for AARD Gene

Domains & Families for AARD Gene

Protein Domains for AARD Gene

ProtoNet:

Suggested Antigen Peptide Sequences for AARD Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with AARD: view

No data available for Gene Families and UniProtKB/Swiss-Prot for AARD Gene

Function for AARD Gene

Phenotypes for AARD Gene

GenomeRNAi human phenotypes for AARD:
genes like me logo Genes that share phenotypes with AARD: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for AARD Gene

Localization for AARD Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AARD Gene COMPARTMENTS Subcellular localization image for AARD gene
Compartment Confidence
cytosol 2
nucleus 2
extracellular 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for AARD Gene

Pathways & Interactions for AARD Gene

SuperPathways for AARD Gene

No Data Available

Interacting Proteins for AARD Gene

Gene Ontology (GO) - Biological Process for AARD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030324 lung development IEA --
genes like me logo Genes that share ontologies with AARD: view

No data available for Pathways by source and SIGNOR curated interactions for AARD Gene

Transcripts for AARD Gene

mRNA/cDNA for AARD Gene

(2) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for AARD Gene

Alanine and arginine rich domain containing protein:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for AARD Gene

No ASD Table

Relevant External Links for AARD Gene

GeneLoc Exon Structure for
AARD
ECgene alternative splicing isoforms for
AARD

Expression for AARD Gene

mRNA expression in normal human tissues for AARD Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for AARD Gene

This gene is overexpressed in Esophagus - Muscularis (x9.6), Testis (x9.1), Esophagus - Gastroesophageal Junction (x7.2), Colon - Sigmoid (x4.5), and Bladder (x4.5).

Protein differential expression in normal tissues from HIPED for AARD Gene

This gene is overexpressed in Adipocyte (66.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for AARD Gene



Protein tissue co-expression partners for AARD Gene

NURSA nuclear receptor signaling pathways regulating expression of AARD Gene:

AARD

SOURCE GeneReport for Unigene cluster for AARD Gene:

Hs.437551
genes like me logo Genes that share expression patterns with AARD: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for AARD Gene

Orthologs for AARD Gene

This gene was present in the common ancestor of mammals.

Orthologs for AARD Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AARD 34 35
  • 98.7 (n)
dog
(Canis familiaris)
Mammalia AARD 35
  • 77 (a)
OneToOne
cow
(Bos Taurus)
Mammalia AARD 34 35
  • 75 (n)
mouse
(Mus musculus)
Mammalia Aard 34 16 35
  • 71.02 (n)
rat
(Rattus norvegicus)
Mammalia Aard 34
  • 70.97 (n)
Species where no ortholog for AARD was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for AARD Gene

ENSEMBL:
Gene Tree for AARD (if available)
TreeFam:
Gene Tree for AARD (if available)

Paralogs for AARD Gene

(1) SIMAP similar genes for AARD Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with AARD: view

No data available for Paralogs for AARD Gene

Variants for AARD Gene

Sequence variations from dbSNP and Humsavar for AARD Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs10100758 -- 116,941,602(+) TTGCT(A/G)TCAGA intron-variant
rs10105065 -- 116,943,027(+) GCACA(C/T)GCGAA downstream-variant-500B, utr-variant-3-prime
rs111477672 -- 116,938,519(+) GAGCA(G/T)AGCTG reference, missense
rs111560272 -- 116,939,588(+) GATTG(C/T)GCCAT intron-variant
rs11271065 -- 116,941,933(+) CTAGA(-/GATCTTTTTTTAAACGCAC)GAGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for AARD Gene

Variant ID Type Subtype PubMed ID
nsv831434 CNV gain 17160897

Variation tolerance for AARD Gene

Residual Variation Intolerance Score: 34.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.89; 83.76% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for AARD Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
AARD

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AARD Gene

Disorders for AARD Gene

Relevant External Links for AARD

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
AARD

No disorders were found for AARD Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for AARD Gene

Publications for AARD Gene

  1. Genome-wide searching of rare genetic variants in WTCCC data. (PMID: 20549515) Feng T. … Zhu X. (Hum. Genet. 2010) 3 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for AARD Gene

Sources for AARD Gene

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