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Aliases for AAR2 Gene

Aliases for AAR2 Gene

  • AAR2 Splicing Factor Homolog 2 3 4 5
  • C20orf4 3 4
  • AAR2 Splicing Factor Homolog (S. Cerevisiae) 2
  • Chromosome 20 Open Reading Frame 4 2
  • CGI-23 3

External Ids for AAR2 Gene

Previous HGNC Symbols for AAR2 Gene

  • C20orf4

Previous GeneCards Identifiers for AAR2 Gene

  • GC20P034825

Summaries for AAR2 Gene

Entrez Gene Summary for AAR2 Gene

  • This gene encodes the homolog of the yeast A1-alpha2 repressin protein that is involved in mRNA splicing. Alternately spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2012]

GeneCards Summary for AAR2 Gene

AAR2 (AAR2 Splicing Factor Homolog) is a Protein Coding gene.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AAR2 Gene

Genomics for AAR2 Gene

Regulatory Elements for AAR2 Gene

Promoters for AAR2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around AAR2 on UCSC Golden Path with GeneCards custom track

Genomic Location for AAR2 Gene

Chromosome:
20
Start:
36,236,417 bp from pter
End:
36,270,918 bp from pter
Size:
34,502 bases
Orientation:
Plus strand

Genomic View for AAR2 Gene

Genes around AAR2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AAR2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AAR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AAR2 Gene

Proteins for AAR2 Gene

  • Protein details for AAR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y312-AAR2_HUMAN
    Recommended name:
    Protein AAR2 homolog
    Protein Accession:
    Q9Y312
    Secondary Accessions:
    • E1P5S7
    • Q9H4F9
    • Q9P1P3
    • Q9UFK9

    Protein attributes for AAR2 Gene

    Size:
    384 amino acids
    Molecular mass:
    43472 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAF29578.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for AAR2 Gene

Proteomics data for AAR2 Gene at MOPED

Post-translational modifications for AAR2 Gene

  • Ubiquitination at Lys 44 and Lys 186
  • Modification sites at PhosphoSitePlus

Other Protein References for AAR2 Gene

Antibody Products

No data available for DME Specific Peptides for AAR2 Gene

Domains & Families for AAR2 Gene

Protein Domains for AAR2 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9Y312

UniProtKB/Swiss-Prot:

AAR2_HUMAN :
  • Belongs to the AAR2 family.
Family:
  • Belongs to the AAR2 family.
genes like me logo Genes that share domains with AAR2: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for AAR2 Gene

Function for AAR2 Gene

genes like me logo Genes that share phenotypes with AAR2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for AAR2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for AAR2 Gene

Localization for AAR2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AAR2 Gene COMPARTMENTS Subcellular localization image for AAR2 gene
Compartment Confidence
cytosol 3
nucleus 2
mitochondrion 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for AAR2 Gene

Pathways & Interactions for AAR2 Gene

SuperPathways for AAR2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for AAR2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for AAR2 Gene

Drugs & Compounds for AAR2 Gene

No Compound Related Data Available

Transcripts for AAR2 Gene

Unigene Clusters for AAR2 Gene

AAR2 splicing factor homolog (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for AAR2 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7a · 7b
SP1: - - -
SP2:
SP3: - - - - -
SP4:
SP5: -

Relevant External Links for AAR2 Gene

GeneLoc Exon Structure for
AAR2
ECgene alternative splicing isoforms for
AAR2

Expression for AAR2 Gene

mRNA expression in normal human tissues for AAR2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for AAR2 Gene

This gene is overexpressed in Bone (28.0) and Breast (17.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for AAR2 Gene



SOURCE GeneReport for Unigene cluster for AAR2 Gene Hs.11314

genes like me logo Genes that share expression patterns with AAR2: view

Protein tissue co-expression partners for AAR2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for AAR2 Gene

Orthologs for AAR2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for AAR2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia AAR2 35
  • 88.77 (n)
  • 91.64 (a)
AAR2 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AAR2 35
  • 90.97 (n)
  • 93.75 (a)
AAR2 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Aar2 35
  • 87.52 (n)
  • 91.1 (a)
Aar2 16
Aar2 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia AAR2 35
  • 99.74 (n)
  • 99.74 (a)
AAR2 36
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Aar2 35
  • 87.61 (n)
  • 90.05 (a)
oppossum
(Monodelphis domestica)
Mammalia AAR2 36
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia AAR2 36
  • 58 (a)
OneToOne
chicken
(Gallus gallus)
Aves C20H20ORF4 35
  • 70.54 (n)
  • 68.07 (a)
C20H20ORF4 36
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia AAR2 36
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia aar2 35
  • 62.7 (n)
  • 58.2 (a)
zebrafish
(Danio rerio)
Actinopterygii aar2 35
  • 62.81 (n)
  • 61.84 (a)
Dr.18910 35
aar2 36
  • 61 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG12320 35
  • 50.85 (n)
  • 37.78 (a)
CG12320 36
  • 32 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F10B5.2 35
  • 48.13 (n)
  • 37.28 (a)
F10B5.2 36
  • 35 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes AAR2 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G66510 35
  • 43.04 (n)
  • 32.42 (a)
rice
(Oryza sativa)
Liliopsida Os04g0132300 35
  • 44.06 (n)
  • 32.48 (a)
Species with no ortholog for AAR2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for AAR2 Gene

ENSEMBL:
Gene Tree for AAR2 (if available)
TreeFam:
Gene Tree for AAR2 (if available)

Paralogs for AAR2 Gene

(9) SIMAP similar genes for AAR2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with AAR2: view

No data available for Paralogs for AAR2 Gene

Variants for AAR2 Gene

Sequence variations from dbSNP and Humsavar for AAR2 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs6121183 - 36,240,238(+) TGGGG(A/C)CTTAC reference, missense
rs709050 -- 36,240,687(+) GTTTT(A/G)GAATA intron-variant
rs716431 -- 36,240,537(+) CCAGC(C/T)GAGAT reference, synonymous-codon
rs2425192 -- 36,242,663(+) gctgg(A/G)attac intron-variant
rs6060871 -- 36,248,496(+) ACGCC(A/C)ACCTA intron-variant

Variation tolerance for AAR2 Gene

Residual Variation Intolerance Score: 80.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.23; 24.60% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for AAR2 Gene

HapMap Linkage Disequilibrium report
AAR2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for AAR2 Gene

Disorders for AAR2 Gene

Relevant External Links for AAR2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
AAR2

No disorders were found for AAR2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for AAR2 Gene

Publications for AAR2 Gene

  1. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  2. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  3. A COFRADIC protocol to study protein ubiquitination. (PMID: 24816145) Stes E. … Gevaert K. (J. Proteome Res. 2014) 3
  4. Quantitative Lys-I/-Gly-Gly (diGly) proteomics coupled with inducible RNAi reveals ubiquitin-mediated proteolysis of DNA damage-inducible transcript 4 (DDIT4) by the E3 ligase HUWE1. (PMID: 25147182) Thompson J.W. … Luchansky S.J. (J. Biol. Chem. 2014) 3
  5. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PMID: 22505724) Udeshi N.D. … Carr S.A. (Mol. Cell Proteomics 2012) 3

Products for AAR2 Gene

Sources for AAR2 Gene

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