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AANAT Gene

protein-coding GIFtS: 65

GC17P071975

arylalkylamine N-acetyltransferase
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
AA-NAT ^², ³
EC 2.3.1.87 ^³
SNAT ^¹, ², ³, ⁵

Descriptions
Aralkylamine N-acetyltransferase ^³
Serotonin acetylase ^³
arylalkylamine N-acetyltransferase ^²
serotonin N-acetyltransferase ^²

External Ids
HGNC: 19¹
Entrez Gene: 15²
UniProtKB: Q16613³
Ensembl: ENSG00000129673⁷

Search outside databases for aliases for AANAT gene

Previous GC identifers: GC17P074297 GC17P077455 GC17P074927 GC17P075060

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for AANAT:

Arylalkylamine N-acetyltransferase belongs to the superfamily of acetyltransferases. It is the

penultimate enzyme in melatonin synthesis and controls the night/day rhythm in melatonin

production in the vertebrate pineal gland. Melatonin is essential for seasonal reproduction,

modulates the function of the circadian clock in the suprachiasmatic nucleus, and influences

activity and sleep. This enzyme is rapidly inactivated when animals are exposed to light at night.

This protein is 80% identical to sheep and rat AA-NAT. Arylalkylamine N-acetyltransferase may

contribute a multifactorial genetic diseases such as altered behavior in sleep/wake cycle.

[provided by RefSeq]

UniProtKB/Swiss-Prot: SNAT_HUMAN, Q16613

Function: Catalyzes the N-acetylation of serotonin into N-acetylserotonin. Controls the night/day

rhythm of melatonin production in the pineal gland. Has a relative affinity for hydroxylated

versus non-hydroxylated arylalkylamines

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the AANAT gene

Entrez Gene cytogenetic band: 17q25 Ensembl cytogenetic band: 17q25.1 HGNC cytogenetic band: 17q25

AANAT Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17P071975: (about GC identifiers)

Start:	71,961,028 bp from pter
End:	71,977,794 bp from pter
Size:	16,767 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000017.9 NT_010641.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: SNAT_HUMAN, Q16613 (See protein sequence)

Recommended Name: Serotonin N-acetyltransferase

Size: 207 amino acids; 23344 Da

Subunit: Monomer (By similarity). Interacts with YWHAZ; the interaction requires phosphorylation on

Thr-31, and modulates the enzymatic activity of AANAT through preventing dephosphorylation and/or

proteolysis and stabilizing substrate binding. Subsequently, a second molecule of AANAT can bind,

via the phosphorylated Ser-205 site, the other YWHAZ monomer with similar effect (By similarity)

Subcellular location: Cytoplasm

Secondary accessions: A0AVF2 Q562F4

Post-translational modifications:

Phosphorylated; cAMP-dependent phosphorylation on both N-terminal and C-terminal sites regulates

AANAT activity through allowing interaction with 14-3-3 proteins and protecting the enzyme against

proteasomal degradation (By similarity)¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_001079.1

ENSEMBL proteins:

ENSP00000250615 ENSP00000376282

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Serotonin N-acetyltransferase)
	Human Recombinant Proteins from Abnova (AANAT)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

Antibodies for AANAT:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of AANAT
	Sigma-Aldrich Antibodies for AANAT
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (Serotonin N-acetyltransferase), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Novus Biologicals Antibodies for SNAT

Assays for AANAT:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q16613

ProtoNet protein and cluster: Q16613

1 Blocks protein family: IPB000182 GCN5-related N-acetyltransferase

UniProtKB/Swiss-Prot: SNAT_HUMAN, Q16613

Similarity: Belongs to the acetyltransferase family. AANAT subfamily

Similarity: Contains 1 N-acetyltransferase domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (AANAT)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001088

Applied Biosystems Silencer® siRNAs for AANAT

Sigma-Aldrich siRNA for AANAT

Sigma-Aldrich shRNA for AANAT

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_001088
Myc/DDK tagged cDNA clone in CMV expression vector: NM_001088
untagged cDNA clone in CMV expression vector: NM_001088

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001088

UniProtKB/Swiss-Prot: SNAT_HUMAN, Q16613

Function: Catalyzes the N-acetylation of serotonin into N-acetylserotonin. Controls the night/day

rhythm of melatonin production in the pineal gland. Has a relative affinity for hydroxylated

versus non-hydroxylated arylalkylamines

Catalytic activity: Acetyl-CoA + a 2-arylethylamine = CoA + an N-acetyl-2-arylethylamine

Biophysicochemical properties: Kinetic parameters: KM=0.13 mM for tryptamine; KM=2.6 mM for

5-hydroxytryptamine; KM=0.55 mM for phenylethylamine; KM=10.6 mM for tyramine;

Enzyme Number (IUBMB): EC 2.3.1.87

Genatlas biochemistry entry for AANAT:

arylalkylamine N-acetyltransferase,23kDa,expressed in the pineal gland,penultimate step in

melatonin synthesis,controlling the circadian rythm of production of melatonin,rhythmic activity

controlled by ICER,an early response repressor

1 MGI phenotypic allele

for Aanat (no phenotypes)

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004059	aralkylamine N-acetyltransferase activity	TAS	8661026
GO:0004060	arylamine N-acetyltransferase activity	IEA	--
GO:0008415	acyltransferase activity	IEA	--
GO:0016740	transferase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Sigma-Aldrich "Your Favorite Gene" Pathway for AANAT (Your Favorite Gene powered by Ingenuity)

Tryptophan Metabolism

GeneDecks AANAT for the pathways selected above

About GeneDecksing

UniProtKB/Swiss-Prot: SNAT_HUMAN, Q16613

Pathway: Aromatic compound metabolism; melatonin biosynthesis; melatonin from serotonin: step 1/2

5/31 Interacting proteins for AANAT (ENSP00000250615³) via UniProtKB, MINT, and/or STRING (see all 31 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
YWHAZ	ENSP00000309503³	STRING (score=.975)
ASMT	ENSP00000370639³	STRING (score=.973)
CREM	ENSP00000333055³	STRING (score=.953)
ARNTL	ENSP00000256172³	STRING (score=.952)
NPAS2	ENSP00000338283³	STRING (score=.938)

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2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007623	circadian rhythm	TAS	8661026
GO:0008152	metabolic process	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Compounds for AANAT available from Tocris Bioscience

Compound	Action	CAS number
N-Acetyltryptamine	Melatonin partial agonist (MT1/MT2). Also MT3 antagonist	[1016-47-3]

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10/25 Novoseek chemical compound relationships for AANAT gene (see all 25 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
arylalkylamine	98.54	188	17164235 (5), 15644438 (3), 7681102 (2), 11313340 (2) (see all 81)
melatonin	92.03	325	12364461 (5), 18569588 (5), 12195298 (4), 17403780 (4) (see all 99)
n-acetyltryptamine	88.52	3	9804794 (1), 2327568 (1)
n-acetylserotonin	87.15	18	10024876 (1), 10722724 (1), 1977416 (1), 9804794 (1) (see all 8)
hydroxyindole	82.55	1	18312298 (1)
tryptamine	75.19	3	9804794 (1), 8520468 (1)
arylamine	69.45	9	8382984 (2), 8520468 (2), 11393533 (1)
acetyl-coa	66.26	16	7712152 (2), 9196290 (1), 10024876 (1), 10722724 (1) (see all 8)
cyclic amp	62.44	27	10820191 (4), 7543927 (2), 7580870 (2), 11506377 (2) (see all 12)
6-sulfatoxymelatonin	59.39	3	16172010 (2)

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1 PharmGKB drug compound relationship for AANAT gene

Drug compound	PharmGKB Relations	PubMed IDs for articles supporting these relationships
isoniazid	PK	12142728

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (AANAT)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001088

Sigma-Aldrich siRNA for AANAT

Sigma-Aldrich shRNA for AANAT

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001088

REFSEQ mRNAs for AANAT gene:

NM_001088.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001088

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001088
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001088
                                 untagged cDNA clone in CMV expression vector: NM_001088

Additional cDNA sequence:

AY055827.1 BC069434.1 BC092430.1 BC126332.1 BC126334.1 BC143989.1 U40347.1

3 DOTS entries:

DT.208592 DT.100670397 DT.99981904

16 AceView cDNA sequences:

BX281912 NM_001088 U40347 BC069434 BQ637944 BU845764 BU931661 AI819939

AY055827 AA084486 AA364412 AA365330 AA722177 BM711585 AW951264 AA757429

highest scoring ESTs for AANAT:

AA365330 AA722177 AA757429 AI819939 BC069434 BM711585 U40347 AA084486 AA364412 BC092430

Unigene Cluster for AANAT:

Arylalkylamine N-acetyltransferase

Hs.431417 [show with all ESTs]

Unigene Representative Sequence: BC092430

GeneLoc Exon Structure

2 Ensembl transcripts including schematic representations:

ENST00000250615 ENST00000392492

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

AANAT expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for AANAT

¹ / ² / ³

3 probe-sets matching AANAT gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
36332_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	U40391	0.20	1.00	0.72	1
207225_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_001088	0.60	1.00	0.82	1
207225_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks AANAT for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GAGACAGCAG

SOURCE GeneReport for Unigene cluster: Hs.431417
Expression variation in blood from EXPOLDB for AANAT
UniProtKB/Swiss-Prot: SNAT_HUMAN, Q16613
Tissue specificity: Highly expressed in pineal gland. Lower levels in the retina and in the Y79
retinoblastoma cell line. Weak expression in several brain regions and in the pituitary gland

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for AANAT gene from 5/9 species (see all 9 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	AANAT¹	--	arylalkylamine N-acetyltransferase	84.54(n) 78.74(a)	483331 XM_540450.1 XP_540450.1
chimpanzee (Pan troglodytes)	AANAT¹	--	arylalkylamine N-acetyltransferase	98.39(n) 97.58(a)	503504 NM_001012440.1 NP_001012442.1
cow (Bos taurus)	AANAT¹	--	arylalkylamine N-acetyltransferase	84.23(n) 77.56(a)	618594 XM_870926.2 XP_876019.2
rat (Rattus norvegicus)	Aanat¹	--	arylalkylamine N-acetyltransferase	84.89(n) 84.24(a)	25120 NM_012818.1 NP_036950.1
mouse (Mus musculus)	Aanat^{1, 5}	11 (70.00 cM)⁵	arylalkylamine N-acetyltransferase^{1, 5}	84.92(n)¹ 86.43(a)¹	11298¹ NM_009591.2¹ NP_033721.1¹ AB013358⁵ AF004108⁵ (see all 14)

About this table Species with no ortholog for AANAT

ENSEMBL Gene Tree for AANAT

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

UniProtKB/Swiss-Prot: SNAT_HUMAN, Q16613

Polymorphism: The variant Thr-129 shows significantly higher frequency in delayed sleep phase

syndrome (DSPS). Expressed in the gastrointestinal tract (GIT), including oral cavity, esophagus,

stomach and duodenum. Expressed in the entero-endocrine (EE) cells of the GIT wall

10/32 NCBI SNPs in AANAT are shown (see all 32 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 36)

AB	SNP ID	Valid	Chr 17 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs3760138^1,2	A,C,F,H	71974704(+)	`GGTGTG/TAGCTG`	1	--	ng5¹		7		EA EU WA NA	2090
	rs34470791^1,2	F	71976466(+)	`CCCCAC/TGTCTG`	1	R/C	mis¹		1		NA	72
--	rs4238989^1,2	A	71974983(+)	`GTGGGC/GTTGTC`	1	--	ng5¹		0	--	--	--	--
	rs2071031^1,2	C	71977491(+)	`CGGGCC/TGCGCT`	1	A/A	syn¹ ese³		0	--	--	--	--
--	rs72466441^1,2	--	71975257(+)	`CCTCTA/GACAGC`	1	--	ut5¹		0	--	--	--	--
--	rs72466439^1,2	--	71974652(+)	`TGGGGC/GGGAGA`	1	--	ng5¹		0	--	--	--	--
--	rs72466450^1,2	--	71977788(+)	`CTCACA/GGCCTG`	1	--	ut3¹		0	--	--	--	--
--	rs72466440^1,2	--	71974806(+)	`AATGGA/GTGGAG`	1	--	ng5¹		0	--	--	--	--
--	rs73996399^1,2	--	71974127(+)	`CAGGGG/TCTGTG`	1	--	ng5¹		0	--	--	--	--
--	rs57197997^1,2	--	71974570(+)	`GGGGTC/TAAAAG`	1	--	ng5¹		0	--	--	--	--

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HapMap Linkage Disequilibrium images for AANAT (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 600950

6 Novoseek disease relationships for AANAT gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
carcinosarcoma	32.77	1	10721063 (1)
retinoblastoma	23.76	5	10496148 (2), 8661026 (1), 8382984 (1)
chemically induced	18.38	1	10721063 (1)
mammary tumor	9.85	1	10721063 (1)
tumors	0.95	3	9600600 (1), 9949305 (1), 10721063 (1)
adenocarcinoma	0.00	1	10721063 (1)

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Human Gene Mutation Database: AANAT
Genetic Association Database: AANAT
Human Genome Epidemiology Navigator: AANAT (10 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/156 PubMed articles for AANAT gene (see all 156 ):

The human serotonin N-acetyltransferase (EC 2.3.1.87) gene (AANAT): structure, chromosomal localization, and tissue expression. (PubMed id 8661026)^{1, 2, 3, 4} Coon S.L....Rodriguez I.R. (1996)
Significant association of the arylalkylamine N-acetyltransferase ( AA-NAT) gene with delayed sleep phase syndrome. (PubMed id 12736803)^{1, 3, 4, 6} Hohjoh H....Tokunaga K. (2003)
cAmp regulation of arylalkylamine N-acetyltransferase (AANAT, EC 2.3.1.87): a new cell line (1E7) provides evidence of intracellular AANAT activation. (PubMed id 11313340)^{1, 3, 4} Coon S.L....Klein D.C. (2001)
Genetic variability of arylalkylamine-N-acetyl-transferase (AA-NAT) gene and human sleep/wake pattern. (PubMed id 15332344)^{1, 3, 6} Wang G.Y....Lee E.J. (2004)
Identification of single-nucleotide polymorphisms (SNPs) of human N-acetyltransferase genes NAT1, NAT2, AANAT, ARD1 and L1CAM in the Japanese population. (PubMed id 11393533)^{1, 3, 6} Sekine A....Nakamura Y. (2001)
A naturally occurring -263G/C variant of the human AA-NAT gene and overnight melatonin production. (PubMed id 14728993)^{1, 3, 6} Ying G.W....Lee E.J. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Arylalkylamine N-acetyltransferase (AANAT) genotype as a personal trait in melatonin synthesis. (PubMed id 18569588)^{1, 3} Blomeke B....Roemer H.C. (2008)
Crystal structure of the 14-3-3zeta:serotonin N-acetyltransferase complex. a role for scaffolding in enzyme regulation. (PubMed id 11336675)^{1, 3} Obsil T.... Dyda F. (2001)
Association study of tryptophan hydroxylase 1 and arylalkylamine N-acetyltransferase polymorphisms with adolescent idiopathic scoliosis in Han Chinese. (PubMed id 18794762)^{1, 3} Wang H....Qiu G. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 15	HGNC: 19	AceView: AANAT	Ensembl:ENSG00000129673	euGenes: HUgn15
ECgene: AANAT	H-InvDB: AANAT

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
SHMPD	http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=AANAT

Licensable Technologies for AANAT
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for AANAT:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for AANAT-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for AANAT		Antibodies for AANAT
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for AANAT		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (AANAT)
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	Custom Service for Rabbit Pab from Full-length Protein

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	Recombinant Proteins (Serotonin N-acetyltransferase)
	Antibodies (Serotonin N-acetyltransferase)

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Tocris compounds for AANAT

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for SNAT

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AANAT Gene

protein-coding GIFtS: 65

Aliases &
Descriptions
for AANAT

Summaries
for AANAT

Genomic Location
for AANAT

Proteins
for AANAT

Protein Domains/
Families
for AANAT

Gene Function
for AANAT

Pathways & Interactions
for AANAT

Drugs & Compounds
for AANAT

Transcripts
for AANAT

Expression
for AANAT

Orthologs
for AANAT

Paralogs
for AANAT

SNPs/Variants
for AANAT

Disorders & Mutations
for AANAT

Medical News
for AANAT

Publications
for AANAT

Search for AANAT

Genome Databases showing AANAT

Other Databases showing AANAT

Specialized Databases showing AANAT

Licensable Technologies
for AANAT

Services
for AANAT

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

AANAT Gene

protein-coding GIFtS: 65

Aliases & Descriptionsfor AANAT

Summariesfor AANAT

Genomic Locationfor AANAT

Proteinsfor AANAT

Protein Domains/Familiesfor AANAT

Gene Functionfor AANAT

Pathways & Interactionsfor AANAT

Drugs & Compoundsfor AANAT

Transcriptsfor AANAT

Expression for AANAT

Orthologsfor AANAT

Paralogsfor AANAT

SNPs/Variantsfor AANAT

Disorders & Mutationsfor AANAT

Medical Newsfor AANAT

Publicationsfor AANAT

Search for AANAT

Genome Databases showing AANAT

Other Databases showing AANAT

Specialized Databases showing AANAT

Licensable Technologiesfor AANAT

Servicesfor AANAT

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for AANAT

Summaries
for AANAT

Genomic Location
for AANAT

Proteins
for AANAT

Protein Domains/
Families
for AANAT

Gene Function
for AANAT

Pathways & Interactions
for AANAT

Drugs & Compounds
for AANAT

Transcripts
for AANAT

Expression
for AANAT

Orthologs
for AANAT

Paralogs
for AANAT

SNPs/Variants
for AANAT

Disorders & Mutations
for AANAT

Medical News
for AANAT

Publications
for AANAT

Licensable Technologies
for AANAT

Services
for AANAT