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Aliases & Descriptions for AAMP
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| | | Descriptions |
|---|
| angio-associated, migratory cell protein 2 |
|
| | Search outside databases for aliases for AAMP genePrevious GC identifers: GC02M217144 GC02M217850 GC02M219092 GC02M219331 GC02M218954 |
Summaries for AAMP(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for AAMP: The gene product is an immunoglobulin-type protein. It is found to be expressed strongly in endothelial cells, cytotrophoblasts, and poorly differentiated colon adenocarcinoma cells found in lymphatics. The protein contains a heparin-binding domain and mediates heparin-sensitive cell adhesion. [provided by RefSeq] UniProtKB/Swiss-Prot: AAMP_HUMAN, Q13685Function: Plays a role in angiogenesis and cell migration. In smooth muscle cell migration, may act through the RhoA pathwayGene Wiki entry for AAMP |
Genomic Location for AAMP
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the AAMP gene 
Entrez Gene cytogenetic band: 2q35 Ensembl cytogenetic band: 2q35 HGNC cytogenetic band: 2qAAMP Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02M218837:
(about GC identifiers)
Start:
|
218,837,096 bp from pter |
End:
|
218,843,137 bp from pter |
Size:
|
6,042 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000002.10 NT_005403.16
| Proteins for AAMP
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: AAMP_HUMAN, Q13685 (See
protein sequence)Recommended Name: Angio-associated migratory cell protein Size: 434 amino acids; 46751 Da
Subcellular location: Cell membrane. Cytoplasm
Secondary accessions: Q8WUJ9 Q96H92REFSEQ proteins: NP_001078.2
ENSEMBL proteins: ENSP00000248450
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
3 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for AAMP: Assays for AAMP: | Protein
Domains/ Families for AAMP(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q13685
ProtoNet protein and cluster: Q13685 1 Blocks protein family: IPB001680 G-protein beta WD-40 repeat signature
UniProtKB/Swiss-Prot: AAMP_HUMAN, Q13685Similarity: Contains 8 WD repeats | Gene Function for AAMP
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001087
Applied Biosystems Silencer® siRNAs for AAMP
Sigma-Aldrich siRNA for AAMP  Sigma-Aldrich shRNA for AAMP  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001087                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_001087                                  untagged cDNA clone in CMV expression vector: NM_001087 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_001087
UniProtKB/Swiss-Prot: AAMP_HUMAN, Q13685Function: Plays a role in angiogenesis and cell migration. In smooth muscle cell migration, may act through the RhoA pathway1 Gene Ontology (GO) molecular function term (links to tree view): About this table | Pathways & Interactions for AAMP
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
1 Interacting protein for AAMP (Q136852) via UniProtKB, MINT, and/or STRINGAbout this table
5 Gene Ontology (GO) biological process terms (links to tree view): About this table
|
Drugs & Compounds for AAMP(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for AAMP
|
Transcripts for AAMP(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001087
Sigma-Aldrich siRNA for AAMP  Sigma-Aldrich shRNA for AAMP  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_001087 REFSEQ mRNAs for AAMP gene: NM_001087.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_001087               OriGene GFP tagged cDNA clone in CMV expression vector: NM_001087                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_001087                                  untagged cDNA clone in CMV expression vector: NM_001087  Additional cDNA sequence: AK131047.1 AK225078.1 BC008809.2 BC014122.2 BC020244.1 BC039866.1 CR456755.1 CR590201.1 CR593855.1 CR594232.1 CR595051.1 CR597015.1 CR597851.1 CR599512.1 CR600072.1 CR602732.1 CR603124.1 CR604187.1 CR604549.1 CR608492.1 CR611211.1 CR617077.1 CR618853.1 CR621167.1 CR622304.1 CR623262.1 CR626270.1 M95627.1 21 DOTS entries: DT.95268738 DT.453474 DT.100881144 DT.95268731 DT.120939968 DT.87015735 DT.120939902 DT.100759266 DT.100881133 DT.91767265 DT.100881117 DT.100881130 DT.100881122 DT.120939847 DT.120939859 DT.100638363 DT.100763260 DT.100881126 DT.100881147 DT.120939814 DT.120939849 24/570 AceView cDNA sequences (see all 570
):CR602732 BE386150 BG696790 BU845203 BM512276 AU280145 BI829493 AU120890 BM693443 BQ216534 AA218784 BI091422 BE388169 BX333689 CR626270 AL138196 BX418328 BI832835 BM726184 BC020244 CR618853 BX332174 CR604549 BM563033
highest scoring ESTs for AAMP:M95627 AA053063 AK131047 AL533354 AL539615 AL702054 AU136179 AW410799 BC014122 BC020244 Unigene Cluster for AAMP: Angio-associated, migratory cell protein Hs.83347 [show with all ESTs]Unigene Representative Sequence: NM_001087
GeneLoc Exon Structure
5/12 Alternative Splicing Database (ASD) splice patterns (SP) for AAMP (see all 12
)
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4a | · | 4b | · | 4c | · | 4d | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | · | 11c | |
| SP1: | |   | |   | |   | |   | - |   | |   | |   | - |   | |   | |   | |   | |   | - |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | - |   | |   | |   | - |   | |   | |   | |   | |   | - |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | - |   | |   | |   | - |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | - |   | |   | |   | - |   | - |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | - |   | |   | |   | - |   | |   | |   | |   | |   | - |   | |   | |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for AAMP
1 Ensembl transcript including schematic representation: ENST00000248450
|
Expression for AAMP
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| AAMP expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for AAMP
1 / 2 / 3 3 probe-sets matching AAMP gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: GGGTGTGTAT
SOURCE GeneReport for Unigene cluster: Hs.83347
Expression variation in blood from EXPOLDB for AAMP UniProtKB/Swiss-Prot: AAMP_HUMAN, Q13685Tissue specificity: Expressed in metastatic melanoma, liver, skin, kidney, heart, lung, lymph node, skeletal muscle and brain, and also in A2058 melanoma cells and activated T cells (at protein level). Expressed in blood vessels. Strongly expressed in endothelial cells, cytotrophoblasts, and poorly differentiated. colon adenocarcinoma cells found in lymphatics |
Orthologs for AAMP
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for AAMP gene from 5/16 species (see all 16
)
About this table Species with no ortholog for AAMP
ENSEMBL Gene Tree for AAMP | Paralogs for AAMP(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| -- |
SNPs/Variants for AAMP(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for AAMP (up to first 250kb)
|
Disorders & Mutations for AAMP
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 603488
|
Medical News for AAMP(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for AAMP (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/13 PubMed articles for AAMP gene (see all 13
):- Identification of a new immunoglobulin superfamily protein expressed in blood vessels with a heparin-binding consensus sequence. (PubMed id 7743515)1, 2, 3, 4 Beckner M.E.... Liotta L.A. (1995)
- Blockade of angio-associated migratory cell protein inhibits smooth muscle cell migration and neointima formation in accelerated atherosclerosis. (PubMed id 18634987)3, 4 Vogt F....Blindt R. (2008)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Angio-associated migratory cell protein is expressed as an extracellular protein by blood-vessel-associated mesenchymal cells. (PubMed id 10329261)3, 4 Beckner M.E....Moul D.E. (1999)
- Extracellular angio-associated migratory cell protein plays a positive role in angiogenesis and is regulated by astrocytes in coculture. (PubMed id 11969303)1, 3 Beckner M.E....Peterson V.A. (2002)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)3 Kimura K.... Sugano S. (2006)
- Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PubMed id 15146197)3 Brandenberger R.... Stanton L.W. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)3 Strausberg R.L....Marra M.A. (2002)
- Construction and characterization of a full length-enriched and a 5'- end-enriched cDNA library. (PubMed id 9373149)3 Suzuki Y.... Sugano S. (1997)
- AAMP, a newly identified protein, shares a common epitope with alpha-actinin and a fast skeletal muscle fiber protein. (PubMed id 8660919)3 Beckner M.E....Liotta L.A. (1996)
|
Search for AAMP
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing AAMP
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing AAMP
(According to HUGE)
About This Section
| -- |
Specialized Databases showing AAMP(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for AAMP(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for AAMP:

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GeneCards Homepage - Last full update: 1 Jul 2009
Incremental update: 13 Oct 2009
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