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AAMP Gene

protein-coding   GIFtS: 56

GC02M218837
angio-associated, migratory cell protein
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Descriptions
angio-associated, migratory cell protein 2
External Ids
HGNC: 181
Entrez Gene: 142
UniProtKB: Q136853
Ensembl: ENSG000001278377
Search outside databases for aliases for AAMP gene

Previous GC identifers: GC02M217144 GC02M217850 GC02M219092 GC02M219331 GC02M218954

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for AAMP:
The gene product is an immunoglobulin-type protein. It is found to be expressed strongly in
endothelial cells, cytotrophoblasts, and poorly differentiated colon adenocarcinoma cells found in
lymphatics. The protein contains a heparin-binding domain and mediates heparin-sensitive cell
adhesion. [provided by RefSeq]

UniProtKB/Swiss-Prot: AAMP_HUMAN, Q13685
Function: Plays a role in angiogenesis and cell migration. In smooth muscle cell migration, may act
through the RhoA pathway

Gene Wiki entry for AAMP

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the AAMP gene  

Entrez Gene cytogenetic band: 2q35   Ensembl cytogenetic band:  2q35   HGNC cytogenetic band: 2q

AAMP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M218837:     (about GC identifiers)

Start:
218,837,096 bp from pter
End:
218,843,137 bp from pter
Size:
6,042 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000002.10  NT_005403.16  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: AAMP_HUMAN, Q13685 (See protein sequence)
Recommended Name: Angio-associated migratory cell protein  
Size: 434 amino acids; 46751 Da
Subcellular location: Cell membrane. Cytoplasm
Secondary accessions: Q8WUJ9 Q96H92

REFSEQ proteins: NP_001078.2  

ENSEMBL proteins: 
ENSP00000248450 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich  
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Browse Abcam for Recombinant Proteins
Human Recombinant Proteins from Abnova (AAMP)
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005737 cytoplasm IEA--
GO:0005886 plasma membrane IEA--
GO:0009986 cell surface IDA10329261
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Antibodies for AAMP: 
Browse Antibodies Central at Invitrogen
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Browse Antibodies at Sigma-Aldrich
Browse R&D Systems for Antibodies
Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
Monoclonal and Polyclonal Antibodies from Abnova (AAMP)
Novus Biologicals Antibody for AAMP

Assays for AAMP: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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5/6 InterPro domains/families (see all 6 ):
 IPR019782 WD40_repeat_2
 IPR019775 WD40_repeat_CS
 IPR017986 WD40_repeat_region
 IPR015943 WD40/YVTN_repeat-like
 IPR001680 WD40_repeat


   GeneDecks  AAMP for the domains selected above  
About GeneDecksing

Graphical View of Domain Structure for InterPro Entry Q13685

ProtoNet protein and cluster: Q13685

1 Blocks protein family: IPB001680 G-protein beta WD-40 repeat signature

UniProtKB/Swiss-Prot: AAMP_HUMAN, Q13685
Similarity: Contains 8 WD repeats

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (AAMP)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001087

              Applied Biosystems Silencer® siRNAs for AAMP

              Sigma-Aldrich siRNA for AAMP  
                     Sigma-Aldrich shRNA for AAMP  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Invitrogen Clones for AAMP
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001087
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001087
                                 untagged cDNA clone in CMV expression vector: NM_001087 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_001087

UniProtKB/Swiss-Prot: AAMP_HUMAN, Q13685
Function: Plays a role in angiogenesis and cell migration. In smooth muscle cell migration, may act
through the RhoA pathway

1 Gene Ontology (GO) molecular function term (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0008201 heparin binding TAS7743515
About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section



1 Interacting protein for AAMP (Q136852) via UniProtKB, MINT, and/or STRING
InteractantInteraction Details
GeneCardExternal ID(s)
TH1LQ8IXH72MINT-64858
About this table

5 Gene Ontology (GO) biological process terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0001525 angiogenesis NAS10329261
GO:0007275 multicellular organismal development IEA--
GO:0010595 positive regulation of endothelial cell migration ISS--
GO:0014909 smooth muscle cell migration IEP18634987
GO:0030154 cell differentiation IEA--
About this table
(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for AAMP

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (AAMP)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001087

              Sigma-Aldrich siRNA for AAMP  
                     Sigma-Aldrich shRNA for AAMP  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_001087  

REFSEQ mRNAs for AAMP gene: 

NM_001087.3   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_001087  

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001087
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001087
                                 untagged cDNA clone in CMV expression vector: NM_001087 

Additional cDNA sequence: 

AK131047.1 AK225078.1 BC008809.2 BC014122.2 BC020244.1 BC039866.1 CR456755.1 CR590201.1 
CR593855.1 CR594232.1 CR595051.1 CR597015.1 CR597851.1 CR599512.1 CR600072.1 CR602732.1 
CR603124.1 CR604187.1 CR604549.1 CR608492.1 CR611211.1 CR617077.1 CR618853.1 CR621167.1 
CR622304.1 CR623262.1 CR626270.1 M95627.1 

21 DOTS entries:

DT.95268738  DT.453474  DT.100881144  DT.95268731  DT.120939968  DT.87015735  DT.120939902  DT.100759266 
DT.100881133  DT.91767265  DT.100881117  DT.100881130  DT.100881122  DT.120939847  DT.120939859  DT.100638363 
DT.100763260  DT.100881126  DT.100881147  DT.120939814  DT.120939849 

24/570 AceView cDNA sequences (see all 570 ):

CR602732 BE386150 BG696790 BU845203 BM512276 AU280145 BI829493 AU120890 
BM693443 BQ216534 AA218784 BI091422 BE388169 BX333689 CR626270 AL138196 
BX418328 BI832835 BM726184 BC020244 CR618853 BX332174 CR604549 BM563033 

highest scoring ESTs for AAMP:

M95627 AA053063 AK131047 AL533354 AL539615 AL702054 AU136179 AW410799 BC014122 BC020244 

Unigene Cluster for AAMP:

Angio-associated, migratory cell protein
Hs.83347  [show with all ESTs]
Unigene Representative Sequence: NM_001087


GeneLoc Exon Structure

5/12 Alternative Splicing Database (ASD) splice patterns (SP) for AAMP (see all 12 )

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c
SP1:                          -                 -                             -                       -                                                         
SP2:                          -                 -                             -                       -                                                         
SP3:                          -                 -                             -                                                                                 
SP4:                          -                 -     -                       -                                                                                 
SP5:                          -                 -                             -                 -     -                                                         

About this scheme

ECgene alternative splicing isoforms for AAMP

1 Ensembl transcript including schematic representation:
ENST00000248450  
(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

AAMP expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for AAMP

1 / 2 / 3

3 probe-sets matching AAMP gene


Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

38434_at2, 3 U95-A 1 1.00 1.00 1.00 1.00 M95627 1.00 1.00 1.00 1

201511_at2, 3 U133-A 1 1.00 1.00 -- -- NM_001087 0.60 1.00 0.82 1

201511_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
About this table
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: GGGTGTGTAT

SOURCE GeneReport for Unigene cluster: Hs.83347

Expression variation in blood from EXPOLDB for AAMP

UniProtKB/Swiss-Prot: AAMP_HUMAN, Q13685
Tissue specificity: Expressed in metastatic melanoma, liver, skin, kidney, heart, lung, lymph node,
skeletal muscle and brain, and also in A2058 melanoma cells and activated T cells (at protein
level). Expressed in blood vessels. Strongly expressed in endothelial cells, cytotrophoblasts, and
poorly differentiated. colon adenocarcinoma cells found in lymphatics

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section


Orthologs for AAMP gene from 5/16 species (see all 16 )
Organism Gene Locus Description Human
Similarity
NCBI accessions
dog
(Canis familiaris)
AAMP1   -- angio-associated, migratory cell protein 91.63(n)
98.85(a)
478908  NM_001013850.1  NP_001013872.1 
chimpanzee
(Pan troglodytes)
AAMP1   -- angio-associated, migratory cell protein 99.46(n)
100(a)
459940  XM_001154321.1  XP_001154321.1 
cow
(Bos taurus)
AAMP1   -- angio-associated, migratory cell protein 92.7(n)
98.62(a)
767919  NM_001076995.1  NP_001070463.1 
rat
(Rattus norvegicus)
Aamp1   -- angio-associated, migratory cell protein 90.09(n)
98.62(a)
301512  XM_217441.4  XP_217441.4 
mouse
(Mus musculus)
Aamp1, 5 1 (41.00 cM)5
angio-associated migratory protein1, 5 89.94(n)1
98.62(a)1
2272901  NM_146110.21  NP_666222.21 
 AK1464705  AK1518205  (see all 23)
About this table        Species with no ortholog for AAMP

ENSEMBL Gene Tree for AAMP
(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

  --
(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10/14 NCBI SNPs in AAMP are shown (see all 14 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 56)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 2 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
------------
rs23058351,2
C,F,H218839046(+) ATGGAT/CAGGGC 1 V/I mis19Minor allele frequency- C:0.08EA EU WA 2324
--
rs46742791,2
A,C218840975(+) CTGTCA/GCCCAG 1 -- int10--------
rs10792041,2
C,F218838758(+) GAGTCG/AGGAAA 1 -- int16Minor allele frequency- A:0.04NA EA 314
rs21687011,2
C218840204(+) CCACTC/TTACAC 1 -- int10--------
rs23058361,2
F218839392(+) TCACTC/TAAGGG 1 -- int11Minor allele frequency- T:0.02EA 1504
rs21687021,2
--218840516(+) TTGTCA/CTCTTC 1 D/E mis10--------
rs23058341,2
--218837384(+) GGAAAA/GTCATC 1 -- ut310--------
rs31779841,2
--218838881(-) CCTGTG/TTTGCT 1 V/F mis1 ese30--------
--
rs730861171,2
--218838477(+) TCACAC/TGCCCT 1 -- int10--------
--
rs353300281,2
--218837631(+) ACCTA-/GGGGCC 1 -- int10--------
About this table

HapMap Linkage Disequilibrium images for AAMP (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 603488

(Possibly Related Articles in Doctor's Guide)
About This Section

  --

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

10/13 PubMed articles for AAMP gene (see all 13 ):
(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)
(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 14 HGNC: 18 AceView: AAMP Ensembl:ENSG00000127837 euGenes: HUgn14
ECgene: AAMP H-InvDB: AAMP
(According to HUGE)
About This Section

  --
(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

NameDescription
ATLAS Chromosomes in Cancer entry for AAMP Genetics and Cytogenetics in Oncology and Haematology
(Available from WIS Yeda, Salk, Tufts)
About This Section

  --
(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for AAMP:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



  Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
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 Predesigned and custom siRNAs for AAMP Browse antibodies at Sigma-Aldrich
 Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
 Lentivirus-delivered shRNAs for AAMP Browse small molecules at Sigma-Aldrich
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 Antibodies for AAMP

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