Free for academic non-profit institutions. Other users need a Commercial license

Aliases for AAMP Gene

Aliases for AAMP Gene

  • Angio Associated Migratory Cell Protein 2 3 5

External Ids for AAMP Gene

Previous GeneCards Identifiers for AAMP Gene

  • GC02M217144
  • GC02M217850
  • GC02M219092
  • GC02M219331
  • GC02M218954
  • GC02M218837
  • GC02M210981

Summaries for AAMP Gene

Entrez Gene Summary for AAMP Gene

  • The gene is a member of the immunoglobulin superfamily. The encoded protein is associated with angiogenesis, with potential roles in endothelial tube formation and the migration of endothelial cells. It may also regulate smooth muscle cell migration via the RhoA pathway. The encoded protein can bind to heparin and may mediate heparin-sensitive cell adhesion. [provided by RefSeq, Oct 2014]

GeneCards Summary for AAMP Gene

AAMP (Angio Associated Migratory Cell Protein) is a Protein Coding gene. Among its related pathways are NOD pathway. GO annotations related to this gene include heparin binding.

UniProtKB/Swiss-Prot for AAMP Gene

  • Plays a role in angiogenesis and cell migration. In smooth muscle cell migration, may act through the RhoA pathway.

Gene Wiki entry for AAMP Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AAMP Gene

Genomics for AAMP Gene

Regulatory Elements for AAMP Gene

Enhancers for AAMP Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F218393 1.9 FANTOM5 Ensembl ENCODE 39.6 -130.9 -130940 14.8 CREB3L1 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 AAMP CNOT9 BCS1L STK36 MIR6513 TMBIM1 PNKD CYP27A1 RNF25 CDK5R2
GH02F217845 1.8 FANTOM5 Ensembl ENCODE 25.5 +417.5 417495 15.3 HDGF PKNOX1 MLX ARNT CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 LOC105373876 STK36 AAMP LOC105373878 BCS1L TNS1 CNOT9 ENSG00000231597 ENSG00000227021 RNF25
GH02F218309 1.7 FANTOM5 Ensembl ENCODE 25.8 -41.8 -41790 4.3 HDGF MLX CREB3L1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 YY1 SLC30A9 ENSG00000261338 AAMP PNKD CNOT9 NHEJ1 USP37 SLC23A3 SLC11A1 BCS1L ANKZF1
GH02F218301 1.3 Ensembl ENCODE 25 -31.3 -31332 0.9 ATF1 ARNT ZFP64 ARID4B DMAP1 ZNF48 ZNF2 GTF3C2 ZNF121 SLC30A9 AAMP PNKD CNOT9 NHEJ1 SLC11A1 CTDSP1 MIR26B USP37 SLC23A3 BCS1L
GH02F218908 1.8 FANTOM5 Ensembl ENCODE 17.2 -639.3 -639342 2.4 HDGF PKNOX1 CREB3L1 MLX WRNIP1 ZFP64 ARID4B SIN3A DMAP1 ZNF143 CNOT9 STK36 AAMP CDK5R2 ENSG00000235024 RNF25 BCS1L LINC00608 FEV CRYBA2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around AAMP on UCSC Golden Path with GeneCards custom track

Promoters for AAMP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000607606 57 2401 HDGF PKNOX1 CREB3L1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9

Genomic Location for AAMP Gene

Chromosome:
2
Start:
218,264,123 bp from pter
End:
218,270,257 bp from pter
Size:
6,135 bases
Orientation:
Minus strand

Genomic View for AAMP Gene

Genes around AAMP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AAMP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AAMP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AAMP Gene

Proteins for AAMP Gene

  • Protein details for AAMP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13685-AAMP_HUMAN
    Recommended name:
    Angio-associated migratory cell protein
    Protein Accession:
    Q13685
    Secondary Accessions:
    • Q8WUJ9
    • Q96H92

    Protein attributes for AAMP Gene

    Size:
    434 amino acids
    Molecular mass:
    46751 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAA68889.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAG33036.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for AAMP Gene

Post-translational modifications for AAMP Gene

  • Ubiquitination at Lys 245
  • Modification sites at PhosphoSitePlus

Other Protein References for AAMP Gene

No data available for DME Specific Peptides for AAMP Gene

Domains & Families for AAMP Gene

Gene Families for AAMP Gene

Suggested Antigen Peptide Sequences for AAMP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q13685

UniProtKB/Swiss-Prot:

AAMP_HUMAN :
  • Contains 8 WD repeats.
Similarity:
  • Contains 8 WD repeats.
genes like me logo Genes that share domains with AAMP: view

Function for AAMP Gene

Molecular function for AAMP Gene

UniProtKB/Swiss-Prot Function:
Plays a role in angiogenesis and cell migration. In smooth muscle cell migration, may act through the RhoA pathway.

Gene Ontology (GO) - Molecular Function for AAMP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008201 heparin binding IDA 7743515
GO:0051082 unfolded protein binding IBA --
genes like me logo Genes that share ontologies with AAMP: view
genes like me logo Genes that share phenotypes with AAMP: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for AAMP Gene

Localization for AAMP Gene

Subcellular locations from UniProtKB/Swiss-Prot for AAMP Gene

Cell membrane. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for AAMP gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytosol 5
cytoskeleton 4
nucleus 2

Gene Ontology (GO) - Cellular Components for AAMP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005886 plasma membrane IEA --
GO:0009986 cell surface IDA 10329261
GO:0015630 microtubule cytoskeleton IDA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with AAMP: view

Pathways & Interactions for AAMP Gene

SuperPathway Contained pathways
1 NOD pathway
genes like me logo Genes that share pathways with AAMP: view

Pathways by source for AAMP Gene

1 BioSystems pathway for AAMP Gene

Gene Ontology (GO) - Biological Process for AAMP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis NAS 10329261
GO:0007275 multicellular organism development IEA --
GO:0010595 positive regulation of endothelial cell migration ISS --
GO:0014909 smooth muscle cell migration IEP 18634987
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with AAMP: view

No data available for SIGNOR curated interactions for AAMP Gene

Transcripts for AAMP Gene

Unigene Clusters for AAMP Gene

Angio-associated, migratory cell protein:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for AAMP Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c
SP1: - - - -
SP2: - - - -
SP3: - - -
SP4: - - - -
SP5: - - - - -
SP6: - - - -
SP7: - -
SP8: - -
SP9: -
SP10: -
SP11: -
SP12:

Relevant External Links for AAMP Gene

GeneLoc Exon Structure for
AAMP
ECgene alternative splicing isoforms for
AAMP

Expression for AAMP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for AAMP Gene

Protein differential expression in normal tissues from HIPED for AAMP Gene

This gene is overexpressed in Lung (9.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for AAMP Gene



Protein tissue co-expression partners for AAMP Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of AAMP Gene:

AAMP

SOURCE GeneReport for Unigene cluster for AAMP Gene:

Hs.83347

mRNA Expression by UniProt/SwissProt for AAMP Gene:

Q13685-AAMP_HUMAN
Tissue specificity: Expressed in metastatic melanoma, liver, skin, kidney, heart, lung, lymph node, skeletal muscle and brain, and also in A2058 melanoma cells and activated T-cells (at protein level). Expressed in blood vessels. Strongly expressed in endothelial cells, cytotrophoblasts, and poorly differentiated. colon adenocarcinoma cells found in lymphatics.
genes like me logo Genes that share expression patterns with AAMP: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for AAMP Gene

Orthologs for AAMP Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for AAMP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AAMP 34 35
  • 99.39 (n)
cow
(Bos Taurus)
Mammalia AAMP 34 35
  • 92.7 (n)
dog
(Canis familiaris)
Mammalia AAMP 34 35
  • 91.09 (n)
rat
(Rattus norvegicus)
Mammalia Aamp 34
  • 89.94 (n)
mouse
(Mus musculus)
Mammalia Aamp 34 16 35
  • 89.78 (n)
oppossum
(Monodelphis domestica)
Mammalia AAMP 35
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 20 (a)
ManyToMany
chicken
(Gallus gallus)
Aves AAMP 34 35
  • 75.04 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 79 (a)
OneToMany
-- 35
  • 75 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia aamp 34
  • 68.79 (n)
Str.15278 34
zebrafish
(Danio rerio)
Actinopterygii aamp 34 35
  • 66.42 (n)
Dr.11399 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011387 34
  • 53.15 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG5114 36 34 35
  • 45.76 (n)
worm
(Caenorhabditis elegans)
Secernentea CELE_Y111B2A.12 34
  • 43.69 (n)
Y111B2A.12 35
  • 29 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SWD3 35
  • 15 (a)
OneToMany
SQT1 37
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G71840 34
  • 47.27 (n)
rice
(Oryza sativa)
Liliopsida Os03g0685600 34
  • 45.36 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 47 (a)
OneToOne
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC25H1.08c 34
  • 44.48 (n)
Species where no ortholog for AAMP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for AAMP Gene

ENSEMBL:
Gene Tree for AAMP (if available)
TreeFam:
Gene Tree for AAMP (if available)

Paralogs for AAMP Gene

No data available for Paralogs for AAMP Gene

Variants for AAMP Gene

Sequence variations from dbSNP and Humsavar for AAMP Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs121434511 Pathogenic 218,270,561(+) TACGG(C/T)GCTGA upstream-variant-2KB, reference, missense
rs121434512 Pathogenic 218,270,555(+) AGCTG(C/T)TACGG upstream-variant-2KB, reference, missense
rs121434513 Pathogenic 218,271,410(+) ACAAG(C/G/T)CTTCT upstream-variant-2KB, reference, missense
rs878855015 Uncertain significance 218,270,600(+) CCTCC(A/G)GGGTA upstream-variant-2KB, reference, missense
rs10193107 -- 218,268,569(+) actcc(C/T)gacct intron-variant, upstream-variant-2KB

Variation tolerance for AAMP Gene

Residual Variation Intolerance Score: 36.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.93; 59.51% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for AAMP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
AAMP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for AAMP Gene

Disorders for AAMP Gene

Relevant External Links for AAMP

Human Genome Epidemiology (HuGE) Navigator
AAMP
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
AAMP

No disorders were found for AAMP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for AAMP Gene

Publications for AAMP Gene

  1. Identification of a new immunoglobulin superfamily protein expressed in blood vessels with a heparin-binding consensus sequence. (PMID: 7743515) Beckner M.E. … Liotta L.A. (Cancer Res. 1995) 2 3 4 22 64
  2. A function for AAMP in Nod2-mediated NF-kappaB activation. (PMID: 19535145) Bielig H. … Kufer T.A. (Mol. Immunol. 2009) 3 22 64
  3. Blockade of angio-associated migratory cell protein inhibits smooth muscle cell migration and neointima formation in accelerated atherosclerosis. (PMID: 18634987) Vogt F. … Blindt R. (J. Am. Coll. Cardiol. 2008) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Extracellular angio-associated migratory cell protein plays a positive role in angiogenesis and is regulated by astrocytes in coculture. (PMID: 11969303) Beckner M.E. … Peterson V.A. (Microvasc. Res. 2002) 3 22 64

Products for AAMP Gene

Sources for AAMP Gene

Content
Loading form....