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Aliases for AAMP Gene

Aliases for AAMP Gene

  • Angio-Associated, Migratory Cell Protein 2 3

External Ids for AAMP Gene

Previous GeneCards Identifiers for AAMP Gene

  • GC02M217144
  • GC02M217850
  • GC02M219092
  • GC02M219331
  • GC02M218954
  • GC02M218837
  • GC02M210981

Summaries for AAMP Gene

Entrez Gene Summary for AAMP Gene

  • The gene is a member of the immunoglobulin superfamily. The encoded protein is associated with angiogenesis, with potential roles in endothelial tube formation and the migration of endothelial cells. It may also regulate smooth muscle cell migration via the RhoA pathway. The encoded protein can bind to heparin and may mediate heparin-sensitive cell adhesion. [provided by RefSeq, Oct 2014]

GeneCards Summary for AAMP Gene

AAMP (Angio-Associated, Migratory Cell Protein) is a Protein Coding gene. Among its related pathways are Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways. GO annotations related to this gene include heparin binding. An important paralog of this gene is WDR61.

UniProtKB/Swiss-Prot for AAMP Gene

  • Plays a role in angiogenesis and cell migration. In smooth muscle cell migration, may act through the RhoA pathway.

Gene Wiki entry for AAMP Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AAMP Gene

Genomics for AAMP Gene

Regulatory Elements for AAMP Gene

Genomic Location for AAMP Gene

Chromosome:
2
Start:
218,264,123 bp from pter
End:
218,270,257 bp from pter
Size:
6,135 bases
Orientation:
Minus strand

Genomic View for AAMP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for AAMP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AAMP Gene

Proteins for AAMP Gene

  • Protein details for AAMP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13685-AAMP_HUMAN
    Recommended name:
    Angio-associated migratory cell protein
    Protein Accession:
    Q13685
    Secondary Accessions:
    • Q8WUJ9
    • Q96H92

    Protein attributes for AAMP Gene

    Size:
    434 amino acids
    Molecular mass:
    46751 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAA68889.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAG33036.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for AAMP Gene

Proteomics data for AAMP Gene at MOPED

Post-translational modifications for AAMP Gene

  • Ubiquitination at Lys 245
  • Modification sites at PhosphoSitePlus

Other Protein References for AAMP Gene

Antibody Products

No data available for DME Specific Peptides for AAMP Gene

Domains & Families for AAMP Gene

Gene Families for AAMP Gene

Suggested Antigen Peptide Sequences for AAMP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q13685

UniProtKB/Swiss-Prot:

AAMP_HUMAN :
  • Contains 8 WD repeats.
Similarity:
  • Contains 8 WD repeats.
genes like me logo Genes that share domains with AAMP: view

Function for AAMP Gene

Molecular function for AAMP Gene

UniProtKB/Swiss-Prot Function:
Plays a role in angiogenesis and cell migration. In smooth muscle cell migration, may act through the RhoA pathway.

Gene Ontology (GO) - Molecular Function for AAMP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0008201 heparin binding TAS 7743515
genes like me logo Genes that share ontologies with AAMP: view
genes like me logo Genes that share phenotypes with AAMP: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for AAMP Gene

Localization for AAMP Gene

Subcellular locations from UniProtKB/Swiss-Prot for AAMP Gene

Cell membrane. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AAMP Gene COMPARTMENTS Subcellular localization image for AAMP gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for AAMP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane IEA --
GO:0009986 cell surface IDA 10329261
genes like me logo Genes that share ontologies with AAMP: view

Pathways & Interactions for AAMP Gene

genes like me logo Genes that share pathways with AAMP: view

Pathways by source for AAMP Gene

1 BioSystems pathway for AAMP Gene

Interacting Proteins for AAMP Gene

Gene Ontology (GO) - Biological Process for AAMP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis NAS 10329261
GO:0010595 positive regulation of endothelial cell migration ISS --
GO:0014909 smooth muscle cell migration IEP 18634987
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with AAMP: view

No data available for SIGNOR curated interactions for AAMP Gene

Drugs & Compounds for AAMP Gene

No Compound Related Data Available

Transcripts for AAMP Gene

Unigene Clusters for AAMP Gene

Angio-associated, migratory cell protein:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for AAMP

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for AAMP Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c
SP1: - - - -
SP2: - - - -
SP3: - - -
SP4: - - - -
SP5: - - - - -
SP6: - - - -
SP7: - -
SP8: - -
SP9: -
SP10: -
SP11: -
SP12:

Relevant External Links for AAMP Gene

GeneLoc Exon Structure for
AAMP
ECgene alternative splicing isoforms for
AAMP

Expression for AAMP Gene

mRNA expression in normal human tissues for AAMP Gene

Protein differential expression in normal tissues from HIPED for AAMP Gene

This gene is overexpressed in Lung (9.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for AAMP Gene



SOURCE GeneReport for Unigene cluster for AAMP Gene Hs.83347

mRNA Expression by UniProt/SwissProt for AAMP Gene

Q13685-AAMP_HUMAN
Tissue specificity: Expressed in metastatic melanoma, liver, skin, kidney, heart, lung, lymph node, skeletal muscle and brain, and also in A2058 melanoma cells and activated T-cells (at protein level). Expressed in blood vessels. Strongly expressed in endothelial cells, cytotrophoblasts, and poorly differentiated. colon adenocarcinoma cells found in lymphatics.
genes like me logo Genes that share expression patterns with AAMP: view

Protein tissue co-expression partners for AAMP Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for AAMP Gene

Orthologs for AAMP Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for AAMP Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia AAMP 35
  • 92.7 (n)
  • 98.62 (a)
AAMP 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AAMP 35
  • 91.09 (n)
  • 97.93 (a)
AAMP 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Aamp 35
  • 89.78 (n)
  • 98.39 (a)
Aamp 16
Aamp 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia AAMP 35
  • 99.39 (n)
  • 100 (a)
AAMP 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Aamp 35
  • 89.94 (n)
  • 98.39 (a)
oppossum
(Monodelphis domestica)
Mammalia AAMP 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 20 (a)
ManyToMany
chicken
(Gallus gallus)
Aves AAMP 35
  • 75.04 (n)
  • 79.95 (a)
AAMP 36
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 75 (a)
OneToMany
-- 36
  • 79 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia aamp 35
  • 68.79 (n)
  • 70.52 (a)
Str.15278 35
zebrafish
(Danio rerio)
Actinopterygii aamp 35
  • 66.42 (n)
  • 64.37 (a)
Dr.11399 35
aamp 36
  • 61 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG5114 37
  • 31 (a)
CG5114 35
  • 45.76 (n)
  • 35.76 (a)
CG5114 36
  • 27 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011387 35
  • 53.15 (n)
  • 42.04 (a)
worm
(Caenorhabditis elegans)
Secernentea CELE_Y111B2A.12 35
  • 43.69 (n)
  • 34.16 (a)
Y111B2A.12 36
  • 29 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SWD3 36
  • 15 (a)
OneToMany
SQT1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G71840 35
  • 47.27 (n)
  • 36.36 (a)
rice
(Oryza sativa)
Liliopsida Os03g0685600 35
  • 45.36 (n)
  • 34.32 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC25H1.08c 35
  • 44.48 (n)
  • 32.21 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 47 (a)
OneToOne
Species with no ortholog for AAMP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for AAMP Gene

ENSEMBL:
Gene Tree for AAMP (if available)
TreeFam:
Gene Tree for AAMP (if available)

Paralogs for AAMP Gene

Paralogs for AAMP Gene

genes like me logo Genes that share paralogs with AAMP: view

Variants for AAMP Gene

Sequence variations from dbSNP and Humsavar for AAMP Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs776854825 -- 218,264,610(+) ATCTC(-/TG)TAAAC splice-acceptor-variant
rs777098467 -- 218,267,503(+) CACTC(-/A)AAAGA reference, frameshift-variant
rs777174790 -- 218,266,006(+) TGCCC(C/T)AGGTT intron-variant
rs777299465 -- 218,267,896(+) GGCTT(-/AC)AGTTG intron-variant
rs777653771 -- 218,265,480(+) CGTAC(C/T)ATGAA intron-variant

Variation tolerance for AAMP Gene

Residual Variation Intolerance Score: 36.83% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.93; 59.51% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for AAMP Gene

HapMap Linkage Disequilibrium report
AAMP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for AAMP Gene

Disorders for AAMP Gene

Relevant External Links for AAMP

Human Genome Epidemiology (HuGE) Navigator
AAMP
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
AAMP
genes like me logo Genes that share disorders with AAMP: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for AAMP Gene

Publications for AAMP Gene

  1. Identification of a new immunoglobulin superfamily protein expressed in blood vessels with a heparin-binding consensus sequence. (PMID: 7743515) Beckner M.E. … Liotta L.A. (Cancer Res. 1995) 2 23 67
  2. A function for AAMP in Nod2-mediated NF-kappaB activation. (PMID: 19535145) Bielig H. … Kufer T.A. (Mol. Immunol. 2009) 23 67
  3. Extracellular angio-associated migratory cell protein plays a positive role in angiogenesis and is regulated by astrocytes in coculture. (PMID: 11969303) Beckner M.E. … Peterson V.A. (Microvasc. Res. 2002) 23 67
  4. The aggregated form of an AAMP derived peptide behaves as a heparin sensitive cell binding agent. (PMID: 18634104) Beckner M.E. … Liotta L.A. (Biotechnol. Bioeng. 1997) 23 67
  5. AAMP, a conserved protein with immunoglobulin and WD40 domains, regulates endothelial tube formation in vitro. (PMID: 8683944) Beckner M.E. … Liotta L.A. (Lab. Invest. 1996) 23 67

Products for AAMP Gene

Sources for AAMP Gene

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