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Aliases for AAMDC Gene

Aliases for AAMDC Gene

  • Adipogenesis Associated Mth938 Domain Containing 2 3 5
  • Adipogenesis Associated Mth938 Domain-Containing Protein 3 4
  • C11orf67 3 4
  • Chromosome 11 Open Reading Frame 67 2
  • Mth938 Domain-Containing Protein 3
  • UPF0366 Protein C11orf67 3
  • PTD015 3
  • CK067 3

External Ids for AAMDC Gene

Previous HGNC Symbols for AAMDC Gene

  • C11orf67

Previous GeneCards Identifiers for AAMDC Gene

  • GC11P077533

Summaries for AAMDC Gene

GeneCards Summary for AAMDC Gene

AAMDC (Adipogenesis Associated Mth938 Domain Containing) is a Protein Coding gene.

UniProtKB/Swiss-Prot for AAMDC Gene

  • May play a role in preadipocyte differentiation and adipogenesis.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AAMDC Gene

Genomics for AAMDC Gene

Regulatory Elements for AAMDC Gene

Enhancers for AAMDC Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G077818 1.4 Ensembl ENCODE 16.1 +0.5 547 5.6 HDGF PKNOX1 CREB3L1 ARNT AGO1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 INTS4 RSF1 RPL21P95 AAMDC ENSG00000255449 LOC101928865 AQP11 ENSG00000254691
GH11G077588 1.4 Ensembl ENCODE 13.5 -230.7 -230716 4.0 HDGF FOXA2 PKNOX1 MLX AGO1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B AAMDC CLNS1A INTS4 GDPD4 AQP11 GC11M077568
GH11G077993 1.2 ENCODE 13.6 +173.8 173849 2.4 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC AAMDC INTS4 KCTD21-AS1 ENSG00000254829
GH11G077877 1 ENCODE 16.1 +57.6 57643 2.0 HDGF MLX AGO1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ZNF207 AAMDC INTS4 KCTD21-AS1 PIR57546 PIR41602
GH11G077958 0.8 ENCODE 17.5 +138.1 138117 1.7 PKNOX1 FOXA2 TCF12 EGR1 FOS NFIC SMARCA4 PBX2 IKZF1 KDM1A INTS4 AAMDC AQP11 ENSG00000255115
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around AAMDC on UCSC Golden Path with GeneCards custom track

Promoters for AAMDC Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000042495 -407 3001 HDGF PKNOX1 CREB3L1 ARNT AGO1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1

Genomic Location for AAMDC Gene

Chromosome:
11
Start:
77,821,107 bp from pter
End:
77,918,432 bp from pter
Size:
97,326 bases
Orientation:
Plus strand

Genomic View for AAMDC Gene

Genes around AAMDC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AAMDC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AAMDC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AAMDC Gene

Proteins for AAMDC Gene

  • Protein details for AAMDC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H7C9-AAMDC_HUMAN
    Recommended name:
    Mth938 domain-containing protein
    Protein Accession:
    Q9H7C9
    Secondary Accessions:
    • Q96AQ4
    • Q9Y6B1

    Protein attributes for AAMDC Gene

    Size:
    122 amino acids
    Molecular mass:
    13332 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for AAMDC Gene

    Alternative splice isoforms for AAMDC Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AAMDC Gene

Post-translational modifications for AAMDC Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for AAMDC Gene

Domains & Families for AAMDC Gene

Protein Domains for AAMDC Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for AAMDC Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H7C9

UniProtKB/Swiss-Prot:

AAMDC_HUMAN :
  • Belongs to the AAMDC family.
Family:
  • Belongs to the AAMDC family.
genes like me logo Genes that share domains with AAMDC: view

No data available for Gene Families for AAMDC Gene

Function for AAMDC Gene

Molecular function for AAMDC Gene

UniProtKB/Swiss-Prot Function:
May play a role in preadipocyte differentiation and adipogenesis.

Gene Ontology (GO) - Molecular Function for AAMDC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with AAMDC: view
genes like me logo Genes that share phenotypes with AAMDC: view

Animal Model Products

CRISPR Products

miRNA for AAMDC Gene

miRTarBase miRNAs that target AAMDC

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for AAMDC Gene

Localization for AAMDC Gene

Subcellular locations from UniProtKB/Swiss-Prot for AAMDC Gene

Cytoplasm. Note=Diffuse distribution with some highly concentrated spots around the nucleus. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for AAMDC gene
Compartment Confidence
nucleus 3
cytosol 3
extracellular 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for AAMDC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm ISS --
genes like me logo Genes that share ontologies with AAMDC: view

Pathways & Interactions for AAMDC Gene

SuperPathways for AAMDC Gene

No Data Available

Interacting Proteins for AAMDC Gene

Gene Ontology (GO) - Biological Process for AAMDC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043066 negative regulation of apoptotic process IBA --
GO:0045600 positive regulation of fat cell differentiation IBA --
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IBA --
genes like me logo Genes that share ontologies with AAMDC: view

No data available for Pathways by source and SIGNOR curated interactions for AAMDC Gene

Transcripts for AAMDC Gene

Unigene Clusters for AAMDC Gene

Adipogenesis associated, Mth938 domain containing:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for AAMDC Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6
SP1: - -
SP2: - - -
SP3: - - -
SP4:

Relevant External Links for AAMDC Gene

GeneLoc Exon Structure for
AAMDC
ECgene alternative splicing isoforms for
AAMDC

Expression for AAMDC Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for AAMDC Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for AAMDC Gene



Protein tissue co-expression partners for AAMDC Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of AAMDC Gene:

AAMDC

SOURCE GeneReport for Unigene cluster for AAMDC Gene:

Hs.745040

Evidence on tissue expression from TISSUES for AAMDC Gene

  • Nervous system(4.3)
  • Heart(2)
  • Muscle(2)
genes like me logo Genes that share expression patterns with AAMDC: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for AAMDC Gene

Orthologs for AAMDC Gene

This gene was present in the common ancestor of chordates.

Orthologs for AAMDC Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C11H11orf67 34
  • 99.73 (n)
AAMDC 35
  • 73 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AAMDC 34 35
  • 92.35 (n)
cow
(Bos Taurus)
Mammalia AAMDC 34 35
  • 90.71 (n)
mouse
(Mus musculus)
Mammalia Aamdc 34 16 35
  • 90.71 (n)
rat
(Rattus norvegicus)
Mammalia Aamdc 34
  • 90.16 (n)
oppossum
(Monodelphis domestica)
Mammalia AAMDC 35
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves C1H11ORF67 34 35
  • 80.6 (n)
lizard
(Anolis carolinensis)
Reptilia AAMDC 35
  • 82 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii aamdc 34 35
  • 70.49 (n)
Species where no ortholog for AAMDC was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for AAMDC Gene

ENSEMBL:
Gene Tree for AAMDC (if available)
TreeFam:
Gene Tree for AAMDC (if available)

Paralogs for AAMDC Gene

No data available for Paralogs for AAMDC Gene

Variants for AAMDC Gene

Sequence variations from dbSNP and Humsavar for AAMDC Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000003919 -- 77,820,697(+) GCCGC(C/T)GCCGC intron-variant, upstream-variant-2KB, reference, synonymous-codon
rs1000101202 -- 77,837,264(+) CCGAG(C/T)AGCTG intron-variant
rs1000113619 -- 77,846,393(+) GCAGG(C/T)AGCTC intron-variant
rs1000180370 -- 77,849,260(+) TGTGT(C/T)GCCCA intron-variant
rs1000189282 -- 77,878,553(+) CCTGA(A/C)AAACA intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for AAMDC Gene

Variant ID Type Subtype PubMed ID
nsv1050891 CNV gain 25217958
nsv1138056 CNV deletion 24896259
nsv520740 CNV gain 19592680
nsv524537 CNV loss 19592680
nsv555453 CNV loss 21841781
nsv975953 CNV duplication 23825009

Variation tolerance for AAMDC Gene

Residual Variation Intolerance Score: 56.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.01; 80.08% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for AAMDC Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
AAMDC

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AAMDC Gene

Disorders for AAMDC Gene

Relevant External Links for AAMDC

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
AAMDC

No disorders were found for AAMDC Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for AAMDC Gene

Publications for AAMDC Gene

  1. LOC66273 isoform 2, a novel protein highly expressed in white adipose tissue, induces adipogenesis in 3T3-L1 cells. (PMID: 22279136) Ma X. … Li D. (J. Nutr. 2012) 2 3 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64
  5. Proteomic analysis of the epidermal growth factor receptor (EGFR) interactome and post-translational modifications associated with receptor endocytosis in response to EGF and stress. (PMID: 24797263) Tong J. … Moran M.F. (Mol. Cell Proteomics 2014) 3 64

Products for AAMDC Gene

Sources for AAMDC Gene

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